3.5.3.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982865&form=6&db=m Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-?1and HES-1 transcripts in 1, 2-dimethylhydrazine-colon carcinogenesis in mice. therapeutic application,unassigned 1,0 3.5.3.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33743287&form=6&db=m Long lasting protective effects of early l-arginine treatment on endothelium in an in vitro study. ongoing research,unassigned 3,0 3.5.3.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16825094&form=6&db=m Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats. causal interaction,ongoing research,unassigned 2,3,0 3.5.3.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20938379&form=6&db=m Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966993&form=6&db=m Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1643605&form=6&db=m Clinical significance of arginase in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797936&form=6&db=m Immunohistochemical study of arginase in cancer of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11249934&form=6&db=m Arginase isoforms in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011984&form=6&db=m Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13489701&form=6&db=m Arginase activity and nucleic acid content in mamary adenocarcinoma and normal homologous tissue of C3H mice. ongoing research,unassigned 4,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935537&form=6&db=m Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22434791&form=6&db=m Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and glypican-3 in fine-needle aspiration biopsies. ongoing research,unassigned 2,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848265&form=6&db=m Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24281232&form=6&db=m Arginase-1: a highly specific marker separating pancreatic adenocarcinoma from hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24541334&form=6&db=m Inhibitory effects of arginase on mammary adenocarcinoma transplants in strain "A" mice. ongoing research,therapeutic application,unassigned 4,2,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24541335&form=6&db=m Effects of adrenocorticotropic hormone (ACTH), cortisone, and arginase on growth of transplanted mammary adenocarcinoma in C3H mice. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25812766&form=6&db=m Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase. ongoing research,unassigned 4,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26030248&form=6&db=m HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27137985&form=6&db=m Arginase-1 is frequently positive in hepatoid adenocarcinomas. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27184483&form=6&db=m Hepatocyte differentiation markers in adenocarcinoma of the prostate: hepatocyte paraffin 1 but not arginase-1 is specifically expressed in a subset of prostatic adenocarcinoma. causal interaction,unassigned 3,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28344866&form=6&db=m CD13(hi) Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma. causal interaction,unassigned 1,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782949&form=6&db=m Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784016&form=6&db=m The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32371580&form=6&db=m DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization. unassigned - 3.5.3.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32415175&form=6&db=m Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30066894&form=6&db=m Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30728077&form=6&db=m Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.5.3.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31051694&form=6&db=m Arginase-1 and HepPar-1 expression in fine-needle aspiration specimens of primary lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Adenocarcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848265&form=6&db=m Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Adenomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32534705&form=6&db=m Immunohistochemical results and case report of an incidental finding of uterine polypoid adenomyoma after long-time therapy for metrorrhagia. unassigned - 3.5.3.1 Adrenoleukodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777806&form=6&db=m [A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta] causal interaction,unassigned 3,0 3.5.3.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583571&form=6&db=m Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124949&form=6&db=m Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727374&form=6&db=m Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD). causal interaction,unassigned 3,0 3.5.3.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320354&form=6&db=m Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation. ongoing research,unassigned 4,0 3.5.3.1 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18271400&form=6&db=m [Clinical and biochemical alterations in rats treated with high doses of vitamin A] causal interaction,diagnostic usage,unassigned 3,1,0 3.5.3.1 Alphavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22972923&form=6&db=m Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.5.3.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19099206&form=6&db=m The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26197808&form=6&db=m Bioinformatics methods in drug repurposing for Alzheimer's disease. causal interaction,unassigned 2,0 3.5.3.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31089055&form=6&db=m L-Norvaline, a new therapeutic agent against Alzheimer's disease. causal interaction,unassigned 1,0 3.5.3.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32046281&form=6&db=m Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811757&form=6&db=m Alzheimer's disease as a chronic maladaptive polyamine stress response. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34046031&form=6&db=m Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-? Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Amebiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31199070&form=6&db=m Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 amino-acid n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 amino-acid n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 Amyloidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519806&form=6&db=m Arginase 1 Insufficiency Precipitates Amyloid-? Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis. unassigned - 3.5.3.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1983181&form=6&db=m Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2429045&form=6&db=m [Study of cerebrospinal fluid arginase activity in the diagnosis of amyotrophic lateral sclerosis] diagnostic usage,unassigned 4,0 3.5.3.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24655927&form=6&db=m Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408267&form=6&db=m Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Anaplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2763451&form=6&db=m Enzymes of oxidant defence system of leucocytes and erythrocytes in bovine anaplasmosis. unassigned - 3.5.3.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863373&form=6&db=m [Arginase activity in plasma and erythrocytes in children with hematologic diseases] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.5.3.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20405289&form=6&db=m Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients. diagnostic usage,unassigned 2,0 3.5.3.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26041418&form=6&db=m Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863373&form=6&db=m [Arginase activity in plasma and erythrocytes in children with hematologic diseases] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.5.3.1 Anemia, Hypochromic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16658052&form=6&db=m Mode of Action of the Toxin from Pseudomonas phaseolicola: I. Toxin Specificity, Chlorosis, and Ornithine Accumulation. therapeutic application,unassigned 1,0 3.5.3.1 Anemia, Pernicious http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13439269&form=6&db=m The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major. ongoing research,unassigned 1,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15998894&form=6&db=m Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16225659&form=6&db=m Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16291595&form=6&db=m Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339702&form=6&db=m Hemolysis-associated pulmonary hypertension in thalassemia. unassigned - 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17353439&form=6&db=m Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897312&form=6&db=m In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18762165&form=6&db=m Cysteine-iron promotes arginase activity by driving the Fenton reaction. causal interaction,unassigned 4,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19073155&form=6&db=m Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway. causal interaction,unassigned 3,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20089363&form=6&db=m Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20405289&form=6&db=m Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients. diagnostic usage,unassigned 2,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26041418&form=6&db=m Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27274608&form=6&db=m Influence of ?S-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27537757&form=6&db=m Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Anemia, Sideroblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1179163&form=6&db=m A case of sideroblastic anaemia associated with marked elevation of erythrocytic arginase activity. causal interaction,unassigned 3,0 3.5.3.1 Angina Pectoris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1139781&form=6&db=m Early diagnosis of myocardial infarction by arginase activity determination. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30792060&form=6&db=m Transforming growth factor ? neutralization finely tunes macrophage phenotype in elastase-induced abdominal aortic aneurysm and is associated with an increase of arginase 1 expression in the aorta. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=164740&form=6&db=m Unsuccessful trial of gene replacement in arginase deficiency. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=481955&form=6&db=m Hyperargininemia with arginase deficiency. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=624188&form=6&db=m Arginase deficiency in multiple tissues in argininemia. causal interaction,unassigned 2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=819629&form=6&db=m Excretion of guanidino-derivates in urine of hyperargininemic patients. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=839368&form=6&db=m Hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=845487&form=6&db=m A simple screening test for arginase deficiency (hyperargininemia). diagnostic usage,therapeutic application,unassigned 3,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=890993&form=6&db=m A simple spot-test for the detection of erythrocyte arginase deficiency. diagnostic usage,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=925998&form=6&db=m Influence of arginase deficiency on amino acid concentrations in sheep erythrocytes with a normal and with a defective transport system for amino acids [proceedings] ongoing research,unassigned 2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1404883&form=6&db=m [The dibasic amino acid metabolic disorders] causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1598908&form=6&db=m Molecular genetic study of human arginase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2291040&form=6&db=m [Late diagnosis of congenital argininemia during administration of sodium valproate] causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2657590&form=6&db=m Hyperargininemia, epilepsy and the metabolism of guanidino compounds. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3104676&form=6&db=m A new case of arginase deficiency in a Spanish male. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3447498&form=6&db=m [Arginase deficiency, congenital hypothyroidism and hepatic fibrosis] causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3540926&form=6&db=m Pteridines and mono-amines: relevance to neurological damage. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3632278&form=6&db=m Liver fibrosis in arginase deficiency. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3760903&form=6&db=m Arginase deficiency and phenylketonuria. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3936352&form=6&db=m Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates. causal interaction,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3943226&form=6&db=m A simple quantitative micromethod of arginase assay in blood spots dried on filter paper. diagnostic usage,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3950825&form=6&db=m Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function. causal interaction,unassigned 2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4078590&form=6&db=m Impaired neurotransmitter amine metabolism in arginase deficiency. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4625814&form=6&db=m Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver. causal interaction,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5438971&form=6&db=m [Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies] unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5438972&form=6&db=m [Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.] unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6404622&form=6&db=m Isoenzyme pattern and immunological properties of arginase in normal and hyperargininemia fibroblasts. ongoing research,unassigned 2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6422160&form=6&db=m A new French-Canadian family affected by hyperargininaemia. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6468738&form=6&db=m Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6729810&form=6&db=m A successful trial of enzyme replacement therapy in a case of argininemia. causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6796772&form=6&db=m Urinary pyrimidine excretion in arginase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6820432&form=6&db=m Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet. therapeutic application,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7159597&form=6&db=m Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity. ongoing research,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7361766&form=6&db=m Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7389092&form=6&db=m Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7717428&form=6&db=m Prenatal diagnosis of the urea cycle diseases: a survey of the European cases. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7967487&form=6&db=m Arginase deficiency presenting with convulsions. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8127062&form=6&db=m Arginase deficiency in two brothers. therapeutic application,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8454280&form=6&db=m Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8474825&form=6&db=m Arginase deficiency presenting as cerebral palsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777806&form=6&db=m [A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta] causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8902193&form=6&db=m Loss of function mutations in conserved regions of the human arginase I gene. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9131018&form=6&db=m Delivery of cytosolic liver arginase into the mitochondrial matrix space: a possible novel site for gene replacement therapy. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295913&form=6&db=m [Proposal for a diet treatment in arginase deficiency] therapeutic application,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9590022&form=6&db=m [Arginase deficiency] unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9686347&form=6&db=m The human arginases and arginase deficiency. ongoing research,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9762606&form=6&db=m Adult-onset arginase deficiency. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771848&form=6&db=m Arginase deficiency. causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10947208&form=6&db=m Arginase deficiency presenting with cerebral oedema and failure to thrive. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11148548&form=6&db=m The nutritional management of urea cycle disorders. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11154268&form=6&db=m Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11746885&form=6&db=m Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry. diagnostic usage,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12052859&form=6&db=m Mouse model for human arginase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640389&form=6&db=m Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema. causal interaction,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605507&form=6&db=m Prenatal diagnosis for arginase deficiency: a case study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465784&form=6&db=m Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546957&form=6&db=m Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15565656&form=6&db=m Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15694174&form=6&db=m Hyperargininemia due to liver arginase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15798789&form=6&db=m Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16233191&form=6&db=m Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16602094&form=6&db=m Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16963300&form=6&db=m A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation. therapeutic application,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098461&form=6&db=m Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513443&form=6&db=m Orotic acid excretion and arginine metabolism. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513445&form=6&db=m Biomarkers identified in inborn errors for lysine, arginine, and ornithine. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17997338&form=6&db=m Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18950360&form=6&db=m Anesthesia in a patient with arginase deficiency: implications and management. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052914&form=6&db=m Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19367256&form=6&db=m Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19486531&form=6&db=m Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19936428&form=6&db=m A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004862&form=6&db=m Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304692&form=6&db=m Creatine metabolism and the urea cycle. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20372170&form=6&db=m Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI. therapeutic application,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20456883&form=6&db=m A long-term survival case of arginase deficiency with severe multicystic white matter and compound mutations. diagnostic usage,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21229317&form=6&db=m Neonatal cholestasis: an uncommon presentation of hyperargininemia. causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21585399&form=6&db=m Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris. ongoing research,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21802329&form=6&db=m Arginase I deficiency: Severe infantile presentation with hyperammonemia: More common than reported? causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22760543&form=6&db=m Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971419&form=6&db=m Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388701&form=6&db=m AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse. causal interaction,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859858&form=6&db=m Five novel mutations in ARG1 gene in Chinese patients of argininemia. causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23920045&form=6&db=m Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24224027&form=6&db=m Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24465919&form=6&db=m Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia. therapeutic application,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814679&form=6&db=m Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24888478&form=6&db=m Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice. causal interaction,ongoing research,unassigned 2,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25474440&form=6&db=m Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25611620&form=6&db=m Anesthetic management of a patient with arginase deficiency undergoing liver transplantation. therapeutic application,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25938595&form=6&db=m Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123990&form=6&db=m Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26310552&form=6&db=m [Seven patients of argininemia with spastic tetraplegia as the first and major symptom and prenatal diagnosis of two fetuses with high risk]. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26358771&form=6&db=m Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26467175&form=6&db=m Arginase-1 deficiency. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27038030&form=6&db=m Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335400&form=6&db=m Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570396&form=6&db=m Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity. therapeutic application,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663197&form=6&db=m Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study. causal interaction,unassigned 2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27761413&form=6&db=m Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27898091&form=6&db=m Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998825&form=6&db=m Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28515179&form=6&db=m Arginase-2 mediates renal ischemia-reperfusion injury. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28566761&form=6&db=m Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659245&form=6&db=m Newborn screening for hyperargininemia due to arginase 1 deficiency. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28747341&form=6&db=m Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187023&form=6&db=m Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423830&form=6&db=m Biochemical markers and neuropsychological functioning in distal urea cycle disorders. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29478971&form=6&db=m Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29724658&form=6&db=m Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29948653&form=6&db=m Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961498&form=6&db=m "Cerebral Palsy" in a Patient With Arginase Deficiency. causal interaction,diagnostic usage,unassigned 3,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30294546&form=6&db=m The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine. therapeutic application,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670878&form=6&db=m Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671984&form=6&db=m A new metabolic disorder in human cationic amino acid transporter-2 that mimics arginase 1 deficiency in newborn screening. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31484827&form=6&db=m Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31501335&form=6&db=m Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31604595&form=6&db=m Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31649772&form=6&db=m Arginase Deficiency Presenting as Acute Encephalopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32025996&form=6&db=m Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32580855&form=6&db=m Hyperargininemic Encephalopathy with Unique Clinical Presentation and Novel Genetic Mutations. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32769929&form=6&db=m A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872442&form=6&db=m Metabolic Serendipities of Expanded Newborn Screening. causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33325055&form=6&db=m Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542202&form=6&db=m Novel ARG1 variants identified in a patient with arginase 1 deficiency. causal interaction,unassigned 1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33561495&form=6&db=m Arginase-1 deficiency in neural cells does not contribute to neurodevelopment or functional outcomes after sciatic nerve injury. causal interaction,unassigned 4,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732618&form=6&db=m Arginine to ornithine ratio as a diagnostic marker in patients with positive newborn screening for hyperargininemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995244&form=6&db=m Review of Multi-Modal Imaging in Urea Cycle Disorders: The Old, the New, the Borrowed, and the Blue. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232532&form=6&db=m Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan. unassigned - 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34343381&form=6&db=m Case series of Arginase 1 deficiency: Expanding the spectrum in hyperargininemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471603&form=6&db=m Creatine metabolism in patients with urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 arginase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100148568&form=6&db=m Isotropic growth of spores and salt tolerance in Aspergillus nidulans ongoing research,unassigned 2,0 3.5.3.1 argininosuccinate lyase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 argininosuccinate lyase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324524&form=6&db=m Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate. diagnostic usage,unassigned 2,0 3.5.3.1 argininosuccinate lyase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 argininosuccinate lyase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423830&form=6&db=m Biochemical markers and neuropsychological functioning in distal urea cycle disorders. causal interaction,unassigned 4,0 3.5.3.1 argininosuccinate lyase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 argininosuccinate lyase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025860&form=6&db=m Clinical and biochemical characteristics of patients with urea cycle disorders in a developing country. causal interaction,unassigned 2,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324524&form=6&db=m Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate. diagnostic usage,unassigned 2,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28608518&form=6&db=m Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders. causal interaction,unassigned 3,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423830&form=6&db=m Biochemical markers and neuropsychological functioning in distal urea cycle disorders. causal interaction,unassigned 4,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 argininosuccinate synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232532&form=6&db=m Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan. unassigned - 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7717428&form=6&db=m Prenatal diagnosis of the urea cycle diseases: a survey of the European cases. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14162426&form=6&db=m ARGININOSUCCINIC ACIDURIA. ARGININOSUCCINASE AND ARGINASE IN HUMAN BLOOD CELLS. ongoing research,unassigned 4,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324524&form=6&db=m Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate. diagnostic usage,unassigned 2,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423830&form=6&db=m Biochemical markers and neuropsychological functioning in distal urea cycle disorders. causal interaction,unassigned 4,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 Argininosuccinic Aciduria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471603&form=6&db=m Creatine metabolism in patients with urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25814956&form=6&db=m Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart. causal interaction,unassigned 1,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12415579&form=6&db=m Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21484767&form=6&db=m Endothelial dysfunction in rat adjuvant-induced arthritis: Up-regulation of the vascular arginase pathway. diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22647483&form=6&db=m Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27267914&form=6&db=m Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28298526&form=6&db=m The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages. unassigned - 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29024866&form=6&db=m Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30119237&form=6&db=m Modulatory effect of eugenol on arginase, nucleotidase, and adenosine deaminase activities of platelets in a carrageenan-induced arthritis rat model: A possible anti-arthritic mechanism of eugenol. ongoing research,unassigned 1,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30887278&form=6&db=m Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30990796&form=6&db=m Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Arthritis, Gouty http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30585453&form=6&db=m [Effect of Electroacupuncture on Synovial M 1/M 2 Macrophage Polarization in Rats with Acute Gouty Arthritis]. ongoing research,unassigned 3,0 3.5.3.1 Arthritis, Reactive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26829838&form=6&db=m [SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11593962&form=6&db=m Arginase levels are increased in patients with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.5.3.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12415579&form=6&db=m Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.5.3.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17435254&form=6&db=m Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29884228&form=6&db=m Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30592386&form=6&db=m Changes in the pattern of cytokine production from peripheral blood mononuclear cells in patients with rheumatoid arthritis treated with infliximab and their relation to plasma arginase activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.5.3.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30887278&form=6&db=m Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33483748&form=6&db=m TNF? induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNF? antibodies. unassigned - 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=643733&form=6&db=m [Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure] causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7413457&form=6&db=m [Sputum arginase activity in bronchial asthma] diagnostic usage,therapeutic application,unassigned 2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12023942&form=6&db=m Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12813015&form=6&db=m Arginase: marker, effector, or candidate gene for asthma? causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12813022&form=6&db=m Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. ongoing research,unassigned 1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12967769&form=6&db=m Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607075&form=6&db=m cNOS-iNOS paradigm and arginase in asthma. unassigned - 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14618299&form=6&db=m Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts. ongoing research,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15070820&form=6&db=m Decreased arginine bioavailability and increased serum arginase activity in asthma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15187136&form=6&db=m Enhancer-mediated control of macrophage-specific arginase I expression. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15621923&form=6&db=m Relationship among manganese, arginase, and nitric oxide in childhood asthma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15755639&form=6&db=m Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15939249&form=6&db=m Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16141432&form=6&db=m Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16185164&form=6&db=m The therapeutic potential of drugs targeting the arginase pathway in asthma. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16257997&form=6&db=m Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16387594&form=6&db=m Genetic polymorphisms in arginase I and II and childhood asthma and atopy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409014&form=6&db=m New Strategies for the Treatment of Pulmonary Hypertension in Sickle Cell Disease : The Rationale for Arginine Therapy. causal interaction,unassigned 3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409620&form=6&db=m Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015747&form=6&db=m Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291856&form=6&db=m Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17410056&form=6&db=m [Arginine metabolism in bronchial asthma] causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691958&form=6&db=m Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide? causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890324&form=6&db=m Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma. ongoing research,unassigned 1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410920&form=6&db=m Arginine homeostasis in allergic asthma. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437360&form=6&db=m Arginase and pulmonary diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18439639&form=6&db=m Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583571&form=6&db=m Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18635886&form=6&db=m Alterations of the arginine metabolome in asthma. diagnostic usage,ongoing research,unassigned 2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18703795&form=6&db=m Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18768883&form=6&db=m Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. causal interaction,unassigned 2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18991648&form=6&db=m Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19027033&form=6&db=m Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19093830&form=6&db=m Probing the specificity determinants of amino acid recognition by arginase. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19229984&form=6&db=m Asthma management: reinventing the wheel in sickle cell disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251784&form=6&db=m L-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction. ongoing research,unassigned 2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19281908&form=6&db=m Roles of arginase variants, atopy, and ozone in childhood asthma. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19286931&form=6&db=m Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19486531&form=6&db=m Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19542246&form=6&db=m Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma. unassigned - 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703164&form=6&db=m Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124949&form=6&db=m Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382750&form=6&db=m Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20441173&form=6&db=m 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21039185&form=6&db=m High Serum Arginase I Levels in Asthma: its Correlation with High-Sensitivity C-Reactive Protein. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078495&form=6&db=m Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? therapeutic application,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21271567&form=6&db=m Increased expression of arginase I and II in allergic nasal mucosa. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21291525&form=6&db=m Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21310883&form=6&db=m Increased arginase activity contributes to airway remodelling in chronic allergic asthma. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21432060&form=6&db=m Mechanisms of occupational asthma: Not all allergens are equal. unassigned - 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21550413&form=6&db=m Modeling gas phase nitric oxide release in lung epithelial cells. causal interaction,unassigned 1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21623460&form=6&db=m Asthma in sickle cell disease. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21685242&form=6&db=m TGF-{beta}2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells. causal interaction,unassigned 3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21728378&form=6&db=m Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design. causal interaction,unassigned 3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21747870&form=6&db=m Arginase and arginine dysregulation in asthma. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22092728&form=6&db=m Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation. ongoing research,unassigned 1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22111529&form=6&db=m Role of arginase in asthma: potential clinical applications. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22246861&form=6&db=m Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses. causal interaction,unassigned 3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22712848&form=6&db=m Pollutant particles induce arginase II in human bronchial epithelial cells. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22798716&form=6&db=m Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915279&form=6&db=m Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23327293&form=6&db=m Impact of substrate protonation and tautomerization States on interactions with the active site of arginase I. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23470627&form=6&db=m Increased Ornithine-Derived Polyamines cause Airways Hyperresponsiveness in a Mouse Model of Asthma. unassigned - 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23554705&form=6&db=m Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23578782&form=6&db=m Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23724233&form=6&db=m Nitric oxide in asthma physiopathology. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23831616&form=6&db=m Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice. causal interaction,ongoing research,unassigned 3,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24107492&form=6&db=m Arginine and asthma. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24150243&form=6&db=m Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. ongoing research,unassigned 2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354980&form=6&db=m Small-molecule arginase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24505101&form=6&db=m Airway arginase expression and N?-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate Lewis and Fischer rat strains. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563530&form=6&db=m Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25150072&form=6&db=m Effects of inhaled L-arginine administration in a murine model of acute asthma. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25612247&form=6&db=m The effects of WW2/WW3 domains of Smurf2 molecule on TGF-? signaling and arginase I gene expression. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789453&form=6&db=m Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963565&form=6&db=m The Promise of Plant-Derived Substances as Inhibitors of Arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25979935&form=6&db=m Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26060350&form=6&db=m l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27214549&form=6&db=m Increased mitochondrial arginine metabolism supports bioenergetics in asthma. causal interaction,unassigned 3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27328636&form=6&db=m Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27734327&form=6&db=m Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28424066&form=6&db=m Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children. diagnostic usage,therapeutic application,unassigned 2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588744&form=6&db=m Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization. diagnostic usage,therapeutic application,unassigned 1,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28797075&form=6&db=m Arginine metabolic endotypes related to asthma severity. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29183288&form=6&db=m Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29729549&form=6&db=m Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29792217&form=6&db=m Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma. causal interaction,unassigned 4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381539&form=6&db=m Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30865303&form=6&db=m Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31996482&form=6&db=m Arginine metabolic control of airway inflammation. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269169&form=6&db=m Pharmacological Screening Identifies SHK242 and SHK277 as Novel Arginase Inhibitors with Efficacy against Allergen-Induced Airway Narrowing In Vitro and In Vivo. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450233&form=6&db=m Insights on the participation of Glu256 and Asp204 in the oligomeric structure and cooperative effects of human arginase type I. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33369279&form=6&db=m Relationship between arginase genes polymorphisms and preschool wheezing phenotypes. causal interaction,unassigned 3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33573660&form=6&db=m Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma. causal interaction,unassigned 2,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33659822&form=6&db=m The role of polymorphic variants of arginase genes (ARG1, ARG2) involved in beta-2-agonist metabolism in the development and course of asthma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33712529&form=6&db=m Mapping Arginase Expression with 18F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary ?-Amino Acids. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833679&form=6&db=m Arginine Therapy for Lung Diseases. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34322123&form=6&db=m Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4. unassigned - 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569838&form=6&db=m Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16284191&form=6&db=m Identification of macrophage arginase I as a new candidate gene of atherosclerosis resistance. causal interaction,ongoing research,unassigned 3,2,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16600160&form=6&db=m Endothelial arginase: a new target in atherosclerosis. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16801563&form=6&db=m Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism. causal interaction,unassigned 4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17008605&form=6&db=m Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369504&form=6&db=m Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18309100&form=6&db=m Endothelial arginase II: a novel target for the treatment of atherosclerosis. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19093830&form=6&db=m Probing the specificity determinants of amino acid recognition by arginase. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19945700&form=6&db=m Regulation of arginase pathway in response to wall shear stress. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20100288&form=6&db=m Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers. therapeutic application,unassigned 4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20111605&form=6&db=m Macrophage plasticity in experimental atherosclerosis. therapeutic application,unassigned 1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20543547&form=6&db=m Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842428&form=6&db=m Arginase type I as a marker of coronary heart disease in hemodialysis patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21151916&form=6&db=m Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21728378&form=6&db=m Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design. causal interaction,unassigned 3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21757649&form=6&db=m LXR{alpha} Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8. causal interaction,unassigned 4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21860589&form=6&db=m Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21860744&form=6&db=m Endothelial arginase II and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22117419&form=6&db=m [Arginase, nitrates, and nitrites in the blood plasma and erythrocytes in hypertension and after therapy with lisinopril and simvastatin]. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22709928&form=6&db=m Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit. causal interaction,unassigned 3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22829869&form=6&db=m Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice. causal interaction,ongoing research,unassigned 3,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23130157&form=6&db=m Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. unassigned - 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23375628&form=6&db=m Transcriptional regulation of macrophage arginase 1 expression and its role in atherosclerosis. ongoing research,unassigned 2,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417041&form=6&db=m Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604721&form=6&db=m Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717158&form=6&db=m Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling. therapeutic application,unassigned 1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717309&form=6&db=m Role of arginase in vessel wall remodeling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23938287&form=6&db=m Arginase II: Atherogenesis Beyond Enzyme Activity. ongoing research,unassigned 1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062745&form=6&db=m Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24183975&form=6&db=m Arginase as a target for treatment of myocardial ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24833798&form=6&db=m Transcriptional regulation of endothelial arginase 2 by histone deacetylase 2. causal interaction,unassigned 4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25484082&form=6&db=m ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963565&form=6&db=m The Promise of Plant-Derived Substances as Inhibitors of Arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064427&form=6&db=m Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis. causal interaction,unassigned 3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27757983&form=6&db=m Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998825&form=6&db=m Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis. causal interaction,unassigned 4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29098611&form=6&db=m Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and L-arginine metabolism in mice. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29487337&form=6&db=m Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30371203&form=6&db=m Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32-Dependent Manner. causal interaction,unassigned 3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31606133&form=6&db=m Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785959&form=6&db=m Improvement in endothelial function in cardiovascular disease - Is arginase the target? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32046324&form=6&db=m p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs. ongoing research,unassigned 3,0 3.5.3.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33961860&form=6&db=m Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Atrioventricular Block http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21844076&form=6&db=m Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation: Implications for the Antiarrhythmic Effect of Statins. unassigned - 3.5.3.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23126644&form=6&db=m Increased circulating myeloid-derived suppressor cells correlated negatively with Th17 cells in patients with rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574762&form=6&db=m Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30797943&form=6&db=m Amino acid metabolism as drug target in autoimmune diseases. ongoing research,unassigned 2,0 3.5.3.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802913&form=6&db=m Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 3.5.3.1 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=420414&form=6&db=m [Importance of arginine content and arginase activity in fertility] diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Azotemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809898&form=6&db=m Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788192&form=6&db=m Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection. diagnostic usage,therapeutic application,unassigned 1,1,0 3.5.3.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18625332&form=6&db=m Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19089467&form=6&db=m Smoking increases salivary arginase activity in patients with dental implants. causal interaction,unassigned 4,0 3.5.3.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20585552&form=6&db=m Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulator. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23041992&form=6&db=m Reduction of salivary arginine catabolic activity through periodontal therapy. unassigned - 3.5.3.1 beta-Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13439269&form=6&db=m The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major. ongoing research,unassigned 1,0 3.5.3.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6195857&form=6&db=m Arginase activity and polyamine biosynthesis in psoriasis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.5.3.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5015509&form=6&db=m [Activity of serum arginase in liver cirrhosis. Its special study in the hemorrhagic syndrome and cirrhogenic encephalopathies] ongoing research,unassigned 2,0 3.5.3.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640389&form=6&db=m Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema. causal interaction,unassigned 1,0 3.5.3.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13859792&form=6&db=m [Arginase and experimental hyperammoniemia. II. Action of arginase on experimental portacaval encephalopathy in the dog.] ongoing research,therapeutic application,unassigned 2,2,0 3.5.3.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21519635&form=6&db=m Molecular pathways differentiate hepatitis C virus (HCV) recurrence from acute cellular rejection in HCV liver recipients. causal interaction,unassigned 2,0 3.5.3.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570396&form=6&db=m Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity. therapeutic application,unassigned 1,0 3.5.3.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31649772&form=6&db=m Arginase Deficiency Presenting as Acute Encephalopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.5.3.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32256357&form=6&db=m Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues. therapeutic application,unassigned 4,0 3.5.3.1 Brain Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32580855&form=6&db=m Hyperargininemic Encephalopathy with Unique Clinical Presentation and Novel Genetic Mutations. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640389&form=6&db=m Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema. causal interaction,unassigned 1,0 3.5.3.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004862&form=6&db=m Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004862&form=6&db=m Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23380531&form=6&db=m Potential role of fibronectin in microglia/macrophage activation following cryoinjury in the rat brain: An immunohistochemical study. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.5.3.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32256357&form=6&db=m Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues. therapeutic application,unassigned 4,0 3.5.3.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30055993&form=6&db=m Arginase overexpression in neurons and its effect on traumatic brain injury. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27308186&form=6&db=m Protective Role of Arginase II in Cerebral Ischemia and Excitotoxicity. causal interaction,unassigned 2,0 3.5.3.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896414&form=6&db=m Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice. unassigned - 3.5.3.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3811280&form=6&db=m [Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.5.3.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28969007&form=6&db=m Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.5.3.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330446&form=6&db=m The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer. unassigned - 3.5.3.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33711670&form=6&db=m Roles of nitric oxide and polyamines in brain tumor growth. unassigned - 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1424158&form=6&db=m Arginase, a new marker of mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10866325&form=6&db=m Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221839&form=6&db=m Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11698350&form=6&db=m Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559605&form=6&db=m Arginase in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928840&form=6&db=m Elevated serum arginase activity levels in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14637283&form=6&db=m Arginase in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15771127&form=6&db=m [Usefulness of postoperative assay of arginase activity in blood serum of women after breast cancer resection] diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17689108&form=6&db=m Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23038227&form=6&db=m Arginase activity in patients with breast cancer: an analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23243594&form=6&db=m Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23581225&form=6&db=m Simvastatin downregulates HER2 via upregulation of PEA3 to induce cell death in HER2-positive breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24223914&form=6&db=m Proteomic identification of mitochondrial targets of arginase in human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310970&form=6&db=m uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25759778&form=6&db=m Effect of rosuvastatin on arginase enzyme activity and polyamine production in experimental breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25812766&form=6&db=m Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase. ongoing research,unassigned 4,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940279&form=6&db=m [The supernatant of 4T1 breast cancer cell culture increases arginase 1 content in ANA-1 macrophages]. diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27066094&form=6&db=m Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27246354&form=6&db=m L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo. causal interaction,diagnostic usage,unassigned 3,2,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27558349&form=6&db=m A nanobiosensor for the detection of arginase activity. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28680747&form=6&db=m Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29854802&form=6&db=m The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30362115&form=6&db=m Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514398&form=6&db=m Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552680&form=6&db=m Key genes and pathways in tumor-educated dendritic cells by bioinformatical analysis. unassigned - 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889032&form=6&db=m PEGylated recombinant human arginase as a drug for breast cancer. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32402274&form=6&db=m Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33476704&form=6&db=m Indicators of L-arginine metabolism in saliva: A focus on breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520398&form=6&db=m Breast cancer derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment. ongoing research,unassigned 2,0 3.5.3.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24919409&form=6&db=m Arginase I gene single-nucleotide polymorphism is associated with decreased risk of pulmonary hypertension in bronchopulmonary dysplasia. causal interaction,unassigned 4,0 3.5.3.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595650&form=6&db=m Arginase Inhibition Prevents Bleomycin-Induced Pulmonary Hypertension, Vascular Remodeling and Collagen Deposition in Neonatal Rat Lungs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895230&form=6&db=m An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 3.5.3.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29266319&form=6&db=m Arginase and ?-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30267614&form=6&db=m Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833679&form=6&db=m Arginine Therapy for Lung Diseases. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578463&form=6&db=m Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 carbamoyl-phosphate synthase (ammonia) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7246541&form=6&db=m Autosomal recessive inheritance of human mitochondrial carbamyl phosphate synthetase deficiency. causal interaction,unassigned 4,0 3.5.3.1 carbamoyl-phosphate synthase (ammonia) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28608518&form=6&db=m Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders. causal interaction,unassigned 3,0 3.5.3.1 carbamoyl-phosphate synthase (ammonia) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29948653&form=6&db=m Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment. causal interaction,unassigned 4,0 3.5.3.1 carbamoyl-phosphate synthase (ammonia) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 carbamoyl-phosphate synthase (ammonia) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232532&form=6&db=m Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan. unassigned - 3.5.3.1 Carbamoyl-Phosphate Synthase I Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7246541&form=6&db=m Autosomal recessive inheritance of human mitochondrial carbamyl phosphate synthetase deficiency. causal interaction,unassigned 4,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5581293&form=6&db=m Arginase and glucose-6-phosphate dehydrogenase activities in spontaneous mammary carcinogenesis. causal interaction,unassigned 2,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11329531&form=6&db=m Significance of arginase and ornithine in malignant tumors of the human skin. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18115918&form=6&db=m Arginase activity and nitrogen content in epidermal carcinogenesis in mice. ongoing research,unassigned 4,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18938447&form=6&db=m Determination of arginase activity in tissue homogenates; application to epidermal carcinogenesis in mice. ongoing research,unassigned 4,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982865&form=6&db=m Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-?1and HES-1 transcripts in 1, 2-dimethylhydrazine-colon carcinogenesis in mice. therapeutic application,unassigned 1,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27363017&form=6&db=m Human cytomegalovirus may promote tumour progression by upregulating arginase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29854802&form=6&db=m The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30151521&form=6&db=m 6-Gingerol as an arginase inhibitor prevents urethane-induced lung carcinogenesis by reprogramming tumor supporting M2 macrophages to M1 phenotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31629728&form=6&db=m The potential therapeutic effect of NG-hydroxy-nor-L-arginine in 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32614387&form=6&db=m Increased Arginase1 expression in tumor microenvironment promotes mammary carcinogenesis via multiple mechanisms. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33712529&form=6&db=m Mapping Arginase Expression with 18F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary ?-Amino Acids. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1424158&form=6&db=m Arginase, a new marker of mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5307510&form=6&db=m Studies on liver arginase in mice with Ehrlich carcinoma. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5307536&form=6&db=m Effect of an alkylating agent on liver arginase in normal and Ehrlich carcinoma bearing mice. ongoing research,unassigned 4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5674790&form=6&db=m Hepatic arginase activity in mice bearing Ehrlich ascites carcinoma. diagnostic usage,ongoing research,unassigned 2,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6189588&form=6&db=m Arginase activity in prostatic tissue of patients with benign prostatic hyperplasia and prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690169&form=6&db=m Study of activities of arginase, hexosaminidase, and leucine aminopeptidase in prostate fluid. diagnostic usage,therapeutic application,unassigned 4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9719479&form=6&db=m Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10738908&form=6&db=m Arginase and ornithine, as markers in human non-small cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270424&form=6&db=m Possible implications of arginase and diamine oxidase in prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592308&form=6&db=m Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13638880&form=6&db=m Arginine uptake and arginase activity in Ehrlich ascites carcinoma cells. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13869315&form=6&db=m [Action of arginine and arginase on the Guerin carcinoma.] diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14844285&form=6&db=m Effects of intraperitoneally injected arginase on growth of mammary carcinoma implants in the mouse. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313928&form=6&db=m Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833831&form=6&db=m Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186186&form=6&db=m Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17255300&form=6&db=m Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17689108&form=6&db=m Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385761&form=6&db=m Humoral autoimmune responses to the squamous cell carcinoma antigen protein family in psoriasis. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817562&form=6&db=m Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18910560&form=6&db=m Some aspects of the role of arginine and arginase in mouse carcinoma 63. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021765&form=6&db=m Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201693&form=6&db=m Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282757&form=6&db=m Arginase activity in carcinoma of the gallbladder: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20466402&form=6&db=m Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21255410&form=6&db=m The immunoregulatory mechanisms of carcinoma for its survival and development. ongoing research,unassigned 4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21633669&form=6&db=m Bioengineered human arginase I with enhanced activity and stability controls hepatocellular and pancreatic carcinoma xenografts. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22298472&form=6&db=m Arginase-1: A novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23111165&form=6&db=m The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23879167&form=6&db=m In vitro repolarized tumor macrophages inhibit gastric tumor growth. ongoing research,unassigned 2,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24541333&form=6&db=m A preliminary report on the histological and histocytochemical changes in mammary carcinoma in mice after intraperitoneal injections of arginase. ongoing research,therapeutic application,unassigned 3,2,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24715304&form=6&db=m Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24915815&form=6&db=m [Significance of arginase-1, glypican-3, hepatocyte paraffin antigen 1 and alpha-fetoprotein in diagnosis and differential diagnosis of liver tumors]. diagnostic usage,ongoing research,unassigned 4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25577247&form=6&db=m Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma. diagnostic usage,unassigned 4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904129&form=6&db=m The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26030248&form=6&db=m HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26300935&form=6&db=m Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26735860&form=6&db=m BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222914&form=6&db=m Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29660463&form=6&db=m Liposomal CpG-ODN: An in vitro and in vivo study on macrophage subtypes responses, biodistribution and subsequent therapeutic efficacy in mice models of cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29751880&form=6&db=m Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883780&form=6&db=m Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29970307&form=6&db=m Increased number of arginase 1-positive cells in the stroma of carcinomas compared to precursor lesions and nonneoplastic tissues. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784016&form=6&db=m The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30808864&form=6&db=m Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278254&form=6&db=m Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31646104&form=6&db=m Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response. unassigned - 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32292567&form=6&db=m Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32996741&form=6&db=m Functions of tumor-associated macrophages and macrophages residing in remote anatomical niches in Ehrlich carcinoma bearing mice. ongoing research,unassigned 1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33785717&form=6&db=m Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031449&form=6&db=m Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367736&form=6&db=m Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527178&form=6&db=m Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27378625&form=6&db=m Oxidative stress, polarization of macrophages and tumour angiogenesis: Efficacy of caffeic acid. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29992073&form=6&db=m Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review. diagnostic usage,unassigned 3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22474&form=6&db=m Establishment of a clonal strain of hepatoma cells derived from Morris hepatoma 8999. ongoing research,unassigned 1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=170626&form=6&db=m Growth inhibitory and arginase activities in liver and hepatoma extracts. ongoing research,unassigned 3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3461568&form=6&db=m Cloning of rat liver arginase cDNA and elucidation of regulation of arginase gene expression in H4 rat hepatoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6265064&form=6&db=m Regulation of urea cycle enzymes in transplantable hepatomas and in the livers of tumor-bearing rats and humans. ongoing research,unassigned 4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7061421&form=6&db=m Regulation of glucocorticoids of arginase and argininosuccinate synthetase in cultured rat hepatoma cells. ongoing research,unassigned 4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7974006&form=6&db=m Functional and molecular analysis of liver arginase promoter sequences from man and Macaca fascicularis. ongoing research,unassigned 3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8089096&form=6&db=m The delayed glucocorticoid-responsive and hepatoma cell-selective enhancer of the rat arginase gene is located around intron 7. ongoing research,unassigned 4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8111729&form=6&db=m Inhibitory effect of arginine restriction on hepatoma growth. ongoing research,therapeutic application,unassigned 2,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8586632&form=6&db=m The delayed glucocorticoid-responsive and hepatoma cell-selective enhancer of the rat arginase gene is located around intron 7. unassigned - 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9891757&form=6&db=m Control of expression of the gene for the arginine transporter Cat-1 in rat liver cells by glucocorticoids and insulin. ongoing research,unassigned 4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911102&form=6&db=m Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210712&form=6&db=m Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17966882&form=6&db=m [Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18831962&form=6&db=m Changes in arginase isoenzymes pattern in human hepatocellular carcinoma. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138817&form=6&db=m Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19374748&form=6&db=m Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC). diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19636440&form=6&db=m Arginase isoenzymes in human cirrhotic liver. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20466402&form=6&db=m Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21423007&form=6&db=m Hepatobiliary pathology. diagnostic usage,therapeutic application,unassigned 3,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22426640&form=6&db=m A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848265&form=6&db=m Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22873218&form=6&db=m Anti-tumor Efficacy of a Recombinant Human Arginase in Human Hepatocellular Carcinoma. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22904131&form=6&db=m Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23111165&form=6&db=m The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23348905&form=6&db=m Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. diagnostic usage,therapeutic application,unassigned 3,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23505904&form=6&db=m Clinicopathological and prognostic implications of arginase expression in hepatocellular carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737831&form=6&db=m An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24246920&form=6&db=m [Role of arginase-1 expression in distinguishing hepatocellular carcinoma from non-hepatocellular tumors]. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24281232&form=6&db=m Arginase-1: a highly specific marker separating pancreatic adenocarcinoma from hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24713397&form=6&db=m Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24911253&form=6&db=m Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24915815&form=6&db=m [Significance of arginase-1, glypican-3, hepatocyte paraffin antigen 1 and alpha-fetoprotein in diagnosis and differential diagnosis of liver tumors]. diagnostic usage,ongoing research,unassigned 4,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25577247&form=6&db=m Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma. diagnostic usage,unassigned 4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25666409&form=6&db=m Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26030248&form=6&db=m HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26230595&form=6&db=m Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26300935&form=6&db=m Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26643895&form=6&db=m Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26735860&form=6&db=m BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26852599&form=6&db=m [Effects of lithium carbonate nanosized particles on nitric oxide production and arginase activity in tumor and peritoneal macrophages in hepatocellular carcinoma 29]. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28395717&form=6&db=m [Arginase inhibitor nor-NOHA induces apoptosis and inhibits invasion and migration of HepG2 cells]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28464918&form=6&db=m Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. ongoing research,therapeutic application,unassigned 2,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28970136&form=6&db=m A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187023&form=6&db=m Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29751880&form=6&db=m Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883780&form=6&db=m Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30066894&form=6&db=m Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155941&form=6&db=m Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784016&form=6&db=m The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31019617&form=6&db=m Prognostic Implications of Arginase and Cytokeratin 19 Expression in Hepatocellular Carcinoma After Curative Hepatectomy: Correlation With Recurrence-Free Survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31051694&form=6&db=m Arginase-1 and HepPar-1 expression in fine-needle aspiration specimens of primary lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31053913&form=6&db=m Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31620648&form=6&db=m Well differentiated arginase-1 negative hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32135940&form=6&db=m A phase 1 study of recombinant human arginase 1 (PEG-BCT- 100) in combination with capecitabine and oxaliplatin in advanced hepatocellular carcinoma patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33256277&form=6&db=m [Study on the clinical significance and correlation of arginase-1 and inducible nitric oxide synthase expression in hepatocellular carcinoma]. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33856599&form=6&db=m A phase II clinical study on the efficacy and predictive biomarker of pegylated recombinant arginase on hepatocellular carcinoma. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33961860&form=6&db=m Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178876&form=6&db=m Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34423599&form=6&db=m Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.5.3.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33785717&form=6&db=m Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367736&form=6&db=m Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10738908&form=6&db=m Arginase and ornithine, as markers in human non-small cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 3.5.3.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19431148&form=6&db=m IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer. unassigned - 3.5.3.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833831&form=6&db=m Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.5.3.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17255300&form=6&db=m Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817562&form=6&db=m Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.5.3.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201693&form=6&db=m Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.5.3.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29754953&form=6&db=m Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. unassigned - 3.5.3.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385761&form=6&db=m Humoral autoimmune responses to the squamous cell carcinoma antigen protein family in psoriasis. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24715304&form=6&db=m Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031449&form=6&db=m Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18475148&form=6&db=m Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 3.5.3.1 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25263201&form=6&db=m Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.5.3.1 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32721242&form=6&db=m Common Variants in the ARG1 Gene Contribute to the Risk of Dilated Cardiomyopathy in the Han Chinese Population. causal interaction,unassigned 3,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19546381&form=6&db=m Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19590038&form=6&db=m Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763131&form=6&db=m Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19945700&form=6&db=m Regulation of arginase pathway in response to wall shear stress. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20071203&form=6&db=m Oxidative stress, l-arginine-nitric oxide and arginase pathways in platelets from adolescents with anorexia nervosa. causal interaction,unassigned 1,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20441173&form=6&db=m 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20543547&form=6&db=m Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21151916&form=6&db=m Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21289285&form=6&db=m Angiotensin II-induced Vascular Endothelial Dysfunction through RhoA/Rho Kinase/p38 Mitogen-Activated Protein Kinase/Arginase Pathway. causal interaction,unassigned 4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21860589&form=6&db=m Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22583316&form=6&db=m Effects of lipoprotein-associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients. causal interaction,unassigned 4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417041&form=6&db=m Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604721&form=6&db=m Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23847624&form=6&db=m The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction. therapeutic application,unassigned 1,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062745&form=6&db=m Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354980&form=6&db=m Small-molecule arginase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24442486&form=6&db=m Human cytomegalovirus induces upregulation of arginase II: possible implications for vasculopathies. causal interaction,unassigned 3,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24757370&form=6&db=m Korean red ginseng water extract restores impaired endothelial function by inhibiting arginase activity in aged mice. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386179&form=6&db=m Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders. ongoing research,unassigned 3,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25446432&form=6&db=m Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway. causal interaction,unassigned 4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25807386&form=6&db=m Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function. unassigned - 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963565&form=6&db=m The Promise of Plant-Derived Substances as Inhibitors of Arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064427&form=6&db=m Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis. causal interaction,unassigned 3,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26140333&form=6&db=m Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232927&form=6&db=m Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28704931&form=6&db=m Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28837342&form=6&db=m Cyperaceae Species Are Potential Sources of Natural Mammalian Arginase Inhibitors with Positive Effects on Vascular Function. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29487337&form=6&db=m Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30526064&form=6&db=m Arginase-1 Variants and the Risk of Familial Coronary Artery Disease in Subjects Originating from Pakistan. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844720&form=6&db=m Mechanisms of obesity-induced metabolic and vascular dysfunctions. causal interaction,unassigned 2,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31743994&form=6&db=m The role of arginase in the microcirculation in cardiovascular disease. ongoing research,unassigned 1,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785959&form=6&db=m Improvement in endothelial function in cardiovascular disease - Is arginase the target? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033258&form=6&db=m Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy? causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32794216&form=6&db=m Metabolite profiling of arginase inhibitor activity guided fraction of Ficus religiosa leaves by LC-HRMS. causal interaction,unassigned 4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32927592&form=6&db=m Mature Twin Neonates Exhibit Oxidative Stress via Nitric Oxide Synthase Dysfunctionality: A Prognostic Stress Marker in the Red Blood Cells and Umbilical Cord Vessels. causal interaction,unassigned 3,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33192610&form=6&db=m ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197620&form=6&db=m Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479657&form=6&db=m Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors. therapeutic application,unassigned 2,0 3.5.3.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6499961&form=6&db=m Urea cycle enzymes in retina, ciliary body-iris, lens and senile cataracts. causal interaction,diagnostic usage,unassigned 3,1,0 3.5.3.1 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033258&form=6&db=m Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy? causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8474825&form=6&db=m Arginase deficiency presenting as cerebral palsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26358771&form=6&db=m Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335400&form=6&db=m Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. causal interaction,unassigned 4,0 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570396&form=6&db=m Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity. therapeutic application,unassigned 1,0 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27898091&form=6&db=m Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31501335&form=6&db=m Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31649772&form=6&db=m Arginase Deficiency Presenting as Acute Encephalopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.5.3.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32769929&form=6&db=m A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30274146&form=6&db=m Insights into the Structural Requirements of 2(S)-Amino-6-Boronohexanoic Acid Derivatives as Arginase I Inhibitors: 3D-QSAR, Docking, and Interaction Fingerprint Studies. causal interaction,unassigned 4,0 3.5.3.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30887278&form=6&db=m Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491849&form=6&db=m Peripheral blood monocytes show morphological pattern of activation and decreased nitric oxide production during acute Chagas' disease in rats. unassigned - 3.5.3.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18422071&form=6&db=m [Macrophages and arginase induction as a mechanism for parasite escape] diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473687&form=6&db=m Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30248443&form=6&db=m Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.5.3.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30555475&form=6&db=m Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection. therapeutic application,unassigned 1,0 3.5.3.1 Chemical and Drug Induced Liver Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402655&form=6&db=m [Effect of Arnica montana tincture on some hydrolytic enzyme activities of rat liver in experimental toxic hepatitis] ongoing research,unassigned 4,0 3.5.3.1 Chemical and Drug Induced Liver Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22872058&form=6&db=m A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase I, and 4-Hydroxyphenyl-Pyruvate Dioxygenase. unassigned - 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848265&form=6&db=m Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23111165&form=6&db=m The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25353287&form=6&db=m Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26300935&form=6&db=m Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26735860&form=6&db=m BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29751880&form=6&db=m Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883780&form=6&db=m Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.5.3.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33482951&form=6&db=m Budd Chiari Syndrome and Intrahepatic Cholangiocarcinoma, An Unusual Combination: Case Report and Review of the Literature. diagnostic usage,unassigned 2,0 3.5.3.1 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282757&form=6&db=m Arginase activity in carcinoma of the gallbladder: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Cholecystitis, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4661849&form=6&db=m [Serum and liver arginase activity in acute cholecystitis] diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Cholecystitis, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4722321&form=6&db=m [Changes of serum arginase in patients with acute cholecystitis and pancreatitis] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2889412&form=6&db=m Alterations in selected serum biochemical constituents in equids after induced hepatic disease. diagnostic usage,ongoing research,unassigned 2,3,0 3.5.3.1 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5802091&form=6&db=m [Changes in arginase activity in various types of experimental cholestasis] ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18227971&form=6&db=m Effect of L: -arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19283445&form=6&db=m Effect of L: -arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123990&form=6&db=m Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574756&form=6&db=m Supplementation with L-arginine affects its metabolizing pathways in rat liver subjected to bile duct ligation. causal interaction,unassigned 3,0 3.5.3.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11218511&form=6&db=m Salivary arginase in patients with adult periodontitis. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15733152&form=6&db=m Effectiveness of scaling and root planing versus modified Widman flap on nitric oxide synthase and arginase activity in patients with chronic periodontitis. diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17701233&form=6&db=m Periodontal therapy reduces arginase activity in saliva of patients with chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12450676&form=6&db=m Diagnosis and monitoring of inborn errors of metabolism using urease-pretreatment of urine, isotope dilution, and gas chromatography-mass spectrometry. causal interaction,diagnostic usage,unassigned 3,1,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025860&form=6&db=m Clinical and biochemical characteristics of patients with urea cycle disorders in a developing country. causal interaction,unassigned 2,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324524&form=6&db=m Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate. diagnostic usage,unassigned 2,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28608518&form=6&db=m Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders. causal interaction,unassigned 3,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423830&form=6&db=m Biochemical markers and neuropsychological functioning in distal urea cycle disorders. causal interaction,unassigned 4,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232532&form=6&db=m Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan. unassigned - 3.5.3.1 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471603&form=6&db=m Creatine metabolism in patients with urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30998505&form=6&db=m Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation. causal interaction,unassigned 3,0 3.5.3.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708913&form=6&db=m Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265947&form=6&db=m Protective role of arginase in a mouse model of colitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23215832&form=6&db=m Inhibition of arginase ameliorates experimental ulcerative colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124254&form=6&db=m Arginase activity in alternatively activated macrophages protects PI3Kp110? deficient mice from dextran sodium sulfate induced intestinal inflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25254662&form=6&db=m Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26885611&form=6&db=m Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice. therapeutic application,unassigned 2,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30277587&form=6&db=m Dietary Nondigestible Polysaccharides Ameliorate Colitis by Improving Gut Microbiota and CD4+ Differentiation, as Well as Facilitating M2 Macrophage Polarization. therapeutic application,unassigned 1,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30606760&form=6&db=m Cinobufacini Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Inhibiting M1 Macrophage Polarization. causal interaction,unassigned 3,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32391010&form=6&db=m Myeloid-Derived Suppressor Cell-Derived Arginase-1 Oppositely Modulates IL-17A and IL-17F Through the ESR/STAT3 Pathway During Colitis in Mice. therapeutic application,unassigned 1,0 3.5.3.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32721946&form=6&db=m Arginase impedes the resolution of colitis by altering the microbiome and metabolome. causal interaction,unassigned 1,0 3.5.3.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23215832&form=6&db=m Inhibition of arginase ameliorates experimental ulcerative colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354980&form=6&db=m Small-molecule arginase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1802207&form=6&db=m Arginine metabolism in benign and malignant disease of breast and colon: evidence for possible inhibition of tumor-infiltrating macrophages. causal interaction,ongoing research,unassigned 3,2,0 3.5.3.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530480&form=6&db=m Arginase activity is inhibited by L-NAME, both in vitro and in vivo. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16218877&form=6&db=m Impact of Mycoplasma hyorhinis infection on L-arginine metabolism: differential regulation of the human and murine iNOS gene. ongoing research,unassigned 3,0 3.5.3.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19997976&form=6&db=m The Redox State of the Glutathione/Glutathione Disulfide Couple Mediates Intracellular Arginase Activation in HCT-116 Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.5.3.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27683110&form=6&db=m Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31088266&form=6&db=m Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 3.5.3.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32979152&form=6&db=m Activation of autophagy following [HuArgI (Co)-PEG5000]-induced arginine deprivation mediates cell death in colon cancer cells. ongoing research,therapeutic application,unassigned 3,4,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1643605&form=6&db=m Clinical significance of arginase in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9338115&form=6&db=m Differences of alkaline phosphatase and arginase activities in human colorectal carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11249934&form=6&db=m Arginase isoforms in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12049190&form=6&db=m Diagnostic performance of arginase activity in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115381&form=6&db=m Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557431&form=6&db=m [Arginase as a marker of cancerogenesis. I. Monitoring patients after resection of colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557432&form=6&db=m [Arginase a marker of cancerogenesis. II. Monitoring of patients after resection of colorectal liver metastases] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15074017&form=6&db=m [Arginase as a marker of cancerogenesis. III. Comparison of arginase activity with CEA and Ca 19-9 in liver metastases of colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16313824&form=6&db=m [Proteome study of colorectal cancer genesis and hepatic metastasis] diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16711512&form=6&db=m Arginase as a useful factor for the diagnosis of colorectal cancer liver metastases. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,3,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101531&form=6&db=m l-Arginine as a factor increasing arginase significance in diagnosis of primary and metastatic colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382585&form=6&db=m Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26030248&form=6&db=m HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890279&form=6&db=m Overexpression of Arginase-1 is an indicator of poor prognosis in patients with colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31795337&form=6&db=m Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33503439&form=6&db=m Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells. ongoing research,unassigned 1,0 3.5.3.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33915902&form=6&db=m Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Coma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052914&form=6&db=m Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency. causal interaction,unassigned 4,0 3.5.3.1 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479657&form=6&db=m Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors. therapeutic application,unassigned 2,0 3.5.3.1 Congenital Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3447498&form=6&db=m [Arginase deficiency, congenital hypothyroidism and hepatic fibrosis] causal interaction,unassigned 4,0 3.5.3.1 Conjunctivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18271400&form=6&db=m [Clinical and biochemical alterations in rats treated with high doses of vitamin A] causal interaction,diagnostic usage,unassigned 3,1,0 3.5.3.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23183942&form=6&db=m Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072937&form=6&db=m Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.5.3.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26140333&form=6&db=m Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30526064&form=6&db=m Arginase-1 Variants and the Risk of Familial Coronary Artery Disease in Subjects Originating from Pakistan. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31228373&form=6&db=m [The role of myeloperoxidase, paraoxonase and nitric oxide system in blood and pericardial fluid in patients with IHD who underwent direct myocardial revascularization.] ongoing research,unassigned 3,0 3.5.3.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303401&form=6&db=m Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842428&form=6&db=m Arginase type I as a marker of coronary heart disease in hemodialysis patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33492309&form=6&db=m Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity. therapeutic application,unassigned 1,0 3.5.3.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33674591&form=6&db=m Deciphering the state of immune silence in fatal COVID-19 patients. unassigned - 3.5.3.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791717&form=6&db=m Transcriptome and Functions of Granulocytic Myeloid-Derived Suppressor Cells Determine their Association with Disease Severity of COVID-19. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806290&form=6&db=m Arginase 1 (Arg1) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy. diagnostic usage,therapeutic application,unassigned 1,1,0 3.5.3.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34088793&form=6&db=m Altered amino acid profile in patients with SARS-CoV-2 infection. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341659&form=6&db=m Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Cross Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28146645&form=6&db=m Early Expansion of Circulating Granulocytic Myeloid-derived Suppressor Cells Predicts Development of Nosocomial Infections in Septic Patients. causal interaction,unassigned 1,0 3.5.3.1 Crush Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13305835&form=6&db=m [Enzymatic activity in the organism in experimental crush syndrome of the limbs. III. Arginase in kidney and liver, glutaminase in kidney.] unassigned - 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166623&form=6&db=m Increased arginase activity in cystic fibrosis airways. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16764721&form=6&db=m Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437360&form=6&db=m Arginase and pulmonary diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071598&form=6&db=m L-ornithine derived polyamines in cystic fibrosis airways. causal interaction,unassigned 4,0 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24804095&form=6&db=m Oscillatory shear stress-induced arginase activity may explain reduced exhaled nitric oxide levels after vest chest physiotherapy in cystic fibrosis. unassigned - 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925982&form=6&db=m Lung arginase expression and activity is increased in cystic fibrosis mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25926674&form=6&db=m Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1. unassigned - 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427400&form=6&db=m ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833679&form=6&db=m Arginine Therapy for Lung Diseases. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Cysticercosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24090570&form=6&db=m Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8447061&form=6&db=m Sarcocystis fusiformis: some protein metabolic enzymes in various fractions of sarcocysts of buffalo (Bubalus bubalis). unassigned - 3.5.3.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21139349&form=6&db=m Th2 Immune Responses and Alternatively Activated Macrophages (AAMacs) in Helminth Infection in Aged Mice. ongoing research,unassigned 2,0 3.5.3.1 Dacryocystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32780506&form=6&db=m Arginase 1 is involved in lacrimal hyposecretion in male NOD mice, a model of Sjögren's syndrome, regardless of dacryoadenitis status. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 3.5.3.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4541165&form=6&db=m Adaptations of amphibian arginase. I. Response to dehydration. therapeutic application,unassigned 1,0 3.5.3.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100143693&form=6&db=m Effect of drought on polyamine metabolism, yield, protein content and in vitro protein digestibility in tepary (Phaseolus acutifolius) and common (Phaseolus vulgaris) bean seeds causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004862&form=6&db=m Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811757&form=6&db=m Alzheimer's disease as a chronic maladaptive polyamine stress response. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29283442&form=6&db=m Myeloid cell plasticity in the evolution of central nervous system autoimmunity. ongoing research,unassigned 4,0 3.5.3.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31859913&form=6&db=m Effect of fasudil on experimental autoimmune neuritis and its mechanisms of action. diagnostic usage,unassigned 1,0 3.5.3.1 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28673038&form=6&db=m Endothelial nitric oxide pathways in the pathophysiology of dengue: a prospective observational study. causal interaction,diagnostic usage,unassigned 3,2,0 3.5.3.1 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25027824&form=6&db=m Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28747341&form=6&db=m Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687346&form=6&db=m Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26704078&form=6&db=m Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18269446&form=6&db=m Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687346&form=6&db=m Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20214019&form=6&db=m Arginase activity and magnesium levels in blood of children with diabetes mellitus. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20942574&form=6&db=m Association of serum arginase I with oxidative stress in a healthy population. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21217072&form=6&db=m Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23183942&form=6&db=m Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417041&form=6&db=m Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763571&form=6&db=m Increased levels of circulating arginase I in overweight compared to normal weight adolescents. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062745&form=6&db=m Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25009624&form=6&db=m Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072937&form=6&db=m Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26140333&form=6&db=m Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26638796&form=6&db=m The Emerging Role of Arginase in Endothelial Dysfunction in Diabetes. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27399350&form=6&db=m Arginase inhibition improves microvascular endothelial function in patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30151846&form=6&db=m Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427970&form=6&db=m The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32708826&form=6&db=m Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5282754&form=6&db=m [The activity of arginase in salivary glands of rats with alloxan diabetes] ongoing research,unassigned 2,0 3.5.3.1 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7461680&form=6&db=m Effect of thyroidectomy & alloxan diabetes on rat brain arginase. ongoing research,unassigned 3,0 3.5.3.1 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22860402&form=6&db=m [The effect of agmatine on L-arginine metabolism in erythrocytes under streptozotocin-induced diabetes in rats]. unassigned - 3.5.3.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12446178&form=6&db=m Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans. causal interaction,unassigned 3,0 3.5.3.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24400007&form=6&db=m l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice. ongoing research,therapeutic application,unassigned 4,3,0 3.5.3.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26140333&form=6&db=m Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28183205&form=6&db=m Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.5.3.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29450408&form=6&db=m Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.5.3.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015037&form=6&db=m Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles. unassigned - 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928367&form=6&db=m Insulin reduces plasma arginase activity in type 2 diabetic patients. causal interaction,unassigned 4,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23183942&form=6&db=m Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25009624&form=6&db=m Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072937&form=6&db=m Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27190086&form=6&db=m Amino acid metabolism reflecting arginase activity is increased in patients with type 2 diabetes and associated with endothelial dysfunction. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27399350&form=6&db=m Arginase inhibition improves microvascular endothelial function in patients with type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30151846&form=6&db=m Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30175269&form=6&db=m Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427970&form=6&db=m The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785959&form=6&db=m Improvement in endothelial function in cardiovascular disease - Is arginase the target? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32107314&form=6&db=m Heparin inhibits pro-inflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32708826&form=6&db=m Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414716&form=6&db=m L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.5.3.1 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24376824&form=6&db=m Increased endothelial inflammation, sTie-2 and arginase activity in umbilical cords obtained from gestational diabetic mothers. diagnostic usage,ongoing research,unassigned 2,4,0 3.5.3.1 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26045778&form=6&db=m Upregulation of arginase activity contributes to intracellular ROS production induced by high glucose in H9c2 cells. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Diabetic Foot http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10382596&form=6&db=m The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1. ongoing research,unassigned 1,0 3.5.3.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21926276&form=6&db=m Arginase-2 mediates diabetic renal injury. ongoing research,unassigned 3,0 3.5.3.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23760286&form=6&db=m Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 3.5.3.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26041444&form=6&db=m Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319431&form=6&db=m Xiao-Shen-Formula, a Traditional Chinese Medicine, Improves Glomerular Hyper-Filtration in Diabetic Nephropathy via Inhibiting Arginase Activation and Heparanase Expression. therapeutic application,unassigned 1,0 3.5.3.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23232640&form=6&db=m The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23840196&form=6&db=m Arginase as a mediator of diabetic retinopathy. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 3.5.3.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29673160&form=6&db=m Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Digestive System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=41466&form=6&db=m Use of plasma arginase and gamma-glutamyl transpeptidase as specific indicators of heptocellular or hepatobiliary disease in the dog. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.5.3.1 Disseminated Intravascular Coagulation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363032&form=6&db=m Transgenic mice overexpressing arginase 1 in monocytic cell lineage are affected by lympho-myeloproliferative disorders and disseminated intravascular coagulation. unassigned - 3.5.3.1 Dystonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30206632&form=6&db=m The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia. causal interaction,unassigned 1,0 3.5.3.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941151&form=6&db=m Arginase and autoimmune inflammation in the central nervous system. ongoing research,unassigned 1,0 3.5.3.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22483960&form=6&db=m Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. causal interaction,ongoing research,unassigned 3,4,0 3.5.3.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22507752&form=6&db=m Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590826&form=6&db=m Metabolic determinants of the immune modulatory function of neural stem cells. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574762&form=6&db=m Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941151&form=6&db=m Arginase and autoimmune inflammation in the central nervous system. ongoing research,unassigned 1,0 3.5.3.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22483960&form=6&db=m Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. causal interaction,ongoing research,unassigned 3,4,0 3.5.3.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22507752&form=6&db=m Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590826&form=6&db=m Metabolic determinants of the immune modulatory function of neural stem cells. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574762&form=6&db=m Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24658839&form=6&db=m Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.5.3.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25425006&form=6&db=m Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells. ongoing research,therapeutic application,unassigned 2,4,0 3.5.3.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20483789&form=6&db=m Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. ongoing research,therapeutic application,unassigned 3,2,0 3.5.3.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24465919&form=6&db=m Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia. therapeutic application,unassigned 1,0 3.5.3.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31159807&form=6&db=m Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015747&form=6&db=m Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.5.3.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19800904&form=6&db=m Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. causal interaction,therapeutic application,unassigned 1,2,0 3.5.3.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706967&form=6&db=m Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23685352&form=6&db=m Broncho-alveolar macrophages express chemokines associated with leukocyte migration in a mouse model of asthma. diagnostic usage,unassigned 2,0 3.5.3.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563530&form=6&db=m Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708913&form=6&db=m Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32108934&form=6&db=m Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis. diagnostic usage,therapeutic application,unassigned 3,1,0 3.5.3.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8099325&form=6&db=m Manganese and epilepsy: brain glutamine synthetase and liver arginase activities in genetically epilepsy prone and chronically seizured rats. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960085&form=6&db=m Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.5.3.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187023&form=6&db=m Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10542097&form=6&db=m Arginase-boronic acid complex highlights a physiological role in erectile function. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350073&form=6&db=m Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11370664&form=6&db=m Expression, purification, and characterization of human type II arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11478904&form=6&db=m Classical and slow-binding inhibitors of human type II arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12859189&form=6&db=m Human arginase II: crystal structure and physiological role in male and female sexual arousal. therapeutic application,unassigned 4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17071735&form=6&db=m Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18269446&form=6&db=m Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19093830&form=6&db=m Probing the specificity determinants of amino acid recognition by arginase. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20441173&form=6&db=m 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20807329&form=6&db=m p38 Mitogen-Activated Protein Kinase (MAPK) Increases Arginase Activity and Contributes to Endothelial Dysfunction in Corpora Cavernosa from Angiotensin-II-Treated Mice. therapeutic application,unassigned 1,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21054801&form=6&db=m Arginase II Deletion Increases Corpora Cavernosa Relaxation in Diabetic Mice. unassigned - 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21728378&form=6&db=m Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design. causal interaction,unassigned 3,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22492840&form=6&db=m Chronic Oral Administration of the Arginase Inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) Improves Erectile Function in Aged Rats. diagnostic usage,unassigned 1,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25195695&form=6&db=m New approaches to the design and discovery of therapies to prevent erectile dysfunction. unassigned - 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537638&form=6&db=m Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26557995&form=6&db=m Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats' Penile Tissues. therapeutic application,unassigned 4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27734327&form=6&db=m Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28374859&form=6&db=m Influence of arginase polymorphisms and arginase levels/activity on the response to erectile dysfunction therapy with sildenafil. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29956132&form=6&db=m Serum Arginase II level can be a novel indicator for erectile dysfunction in patients with vasculogenic erectile dysfunction: a comparative study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,3 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31353610&form=6&db=m Phenolic analysis and erectogenic function of African Walnut (Tetracarpidium conophorum) seeds: The impact of the seed shell on biological activity. ongoing research,unassigned 1,0 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428650&form=6&db=m Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model. unassigned - 3.5.3.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32538504&form=6&db=m Moringa oleifera leaf and seed inclusive diets influenced the restoration of biochemicals associated with erectile dysfunction in the penile tissue of STZ-induced diabetic male rats treated with/without Acarbose drug. ongoing research,unassigned 2,0 3.5.3.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20219858&form=6&db=m Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Fallopian Tube Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27141394&form=6&db=m Immunosuppressive parameters in serum of ovarian cancer patients change during the disease course. ongoing research,unassigned 2,0 3.5.3.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25234945&form=6&db=m Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25678387&form=6&db=m Arginase 1: a potential marker of a common pattern of liver steatosis in HCV and NAFLD children. causal interaction,unassigned 2,0 3.5.3.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30914267&form=6&db=m Macrophage p38? promotes nutritional steatohepatitis through M1 polarization. ongoing research,therapeutic application,unassigned 2,4,0 3.5.3.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33550112&form=6&db=m Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 3.5.3.1 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29741931&form=6&db=m Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction. ongoing research,unassigned 2,0 3.5.3.1 Fibromyalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19523030&form=6&db=m Arginase, NOS activities, and clinical features in fibromyalgia patients. causal interaction,diagnostic usage,unassigned 1,4,0 3.5.3.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4323137&form=6&db=m Properties of arginase from SV40-induced hamster fibrosarcomas and hamster liver tissues. ongoing research,unassigned 2,0 3.5.3.1 Foot Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10382596&form=6&db=m The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1. ongoing research,unassigned 1,0 3.5.3.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282757&form=6&db=m Arginase activity in carcinoma of the gallbladder: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11971019&form=6&db=m Helicobacter pylori induces macrophage apoptosis by activation of arginase II. causal interaction,unassigned 3,0 3.5.3.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27074721&form=6&db=m Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31320834&form=6&db=m Arginase-1 and Treg Profile Appear to Modulate Inflammatory Process in Patients with Chronic Gastritis: IL-33 May Be the Alarm Cytokine in H. pylori-Positive Patients. causal interaction,unassigned 4,0 3.5.3.1 Gastroenteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663197&form=6&db=m Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study. causal interaction,unassigned 2,0 3.5.3.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21644036&form=6&db=m Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23559324&form=6&db=m Liver transplantation prevents progressive neurological impairment in argininemia. causal interaction,unassigned 4,0 3.5.3.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859858&form=6&db=m Five novel mutations in ARG1 gene in Chinese patients of argininemia. causal interaction,unassigned 3,0 3.5.3.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28089752&form=6&db=m Three novel mutations of ARG1 identified in Chinese patients with argininemia detected by newborn screening. causal interaction,unassigned 4,0 3.5.3.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28566761&form=6&db=m Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961243&form=6&db=m Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Giardiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25797399&form=6&db=m Macrophages expressing arginase 1 and nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20831369&form=6&db=m Arginine-Nitric Oxide-Polyamine Metabolism in Periodontal Disease. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8997586&form=6&db=m Congenital glaucoma associated with an arginase deficit: a case report. causal interaction,unassigned 4,0 3.5.3.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21636707&form=6&db=m Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.5.3.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310970&form=6&db=m uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25567351&form=6&db=m Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells. ongoing research,unassigned 4,0 3.5.3.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27006175&form=6&db=m Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27431689&form=6&db=m Low expressions of ASS1 and OTC in glioblastoma suggest the potential clinical use of recombinant human arginase (rhArg). ongoing research,therapeutic application,unassigned 1,3,0 3.5.3.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28718378&form=6&db=m MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 3.5.3.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3811280&form=6&db=m [Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.5.3.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21636707&form=6&db=m Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.5.3.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24030977&form=6&db=m Granulocyte Macrophage-Colony Stimulation Factor Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-? causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27006175&form=6&db=m Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27287871&form=6&db=m Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1. ongoing research,unassigned 1,0 3.5.3.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34504786&form=6&db=m A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment. therapeutic application,unassigned 4,0 3.5.3.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280702&form=6&db=m Arginase is a major pathway of L-arginine metabolism in nephritic glomeruli. causal interaction,unassigned 4,0 3.5.3.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7524362&form=6&db=m Arginine metabolism in experimental glomerulonephritis: interaction between nitric oxide synthase and arginase. ongoing research,therapeutic application,unassigned 1,3,0 3.5.3.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9530263&form=6&db=m Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells. ongoing research,unassigned 4,0 3.5.3.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10810229&form=6&db=m Arginase in glomerulonephritis. causal interaction,unassigned 3,0 3.5.3.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11849441&form=6&db=m Arginase in glomerulonephritis. causal interaction,unassigned 1,0 3.5.3.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30581575&form=6&db=m Role of Metabolites of Nitric Oxide and Arginase in the Pathogenesis of Glomerulonephritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.5.3.1 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25009624&form=6&db=m Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30962478&form=6&db=m Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting. ongoing research,therapeutic application,unassigned 3,2,0 3.5.3.1 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21040785&form=6&db=m Extracorporeal photochemotherapy induces arginase 1 in patients with graft versus host disease. therapeutic application,unassigned 1,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714822&form=6&db=m Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500663&form=6&db=m Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16629702&form=6&db=m Immunohistological features of visceral leishmaniasis in BALB/c mice. ongoing research,unassigned 1,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17853411&form=6&db=m TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response. diagnostic usage,unassigned 2,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19891612&form=6&db=m IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages. ongoing research,unassigned 3,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20502521&form=6&db=m IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness. unassigned - 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20507624&form=6&db=m High gene expression of inflammatory markers and IL-17A correlates with severity of injection site reactions of Atlantic salmon vaccinated with oil-adjuvanted vaccines. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21356378&form=6&db=m M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis. ongoing research,unassigned 3,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21810309&form=6&db=m Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages. ongoing research,unassigned 4,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22827286&form=6&db=m Arginase-1 expression in granulomas of tuberculosis patients. diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23749634&form=6&db=m Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24492801&form=6&db=m Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. unassigned - 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24979482&form=6&db=m The IL-13/IL-4R? axis is involved in tuberculosis-associated pathology. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25201986&form=6&db=m Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. ongoing research,unassigned 3,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26490974&form=6&db=m Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration. unassigned - 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26886778&form=6&db=m Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice. diagnostic usage,unassigned 3,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034399&form=6&db=m Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model. ongoing research,unassigned 1,0 3.5.3.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30418569&form=6&db=m Paracoccidioidomycosis: characterization of subpopulations of macrophages and cytokines in human mucosal lesions. ongoing research,unassigned 2,0 3.5.3.1 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556586&form=6&db=m Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO. ongoing research,unassigned 4,0 3.5.3.1 guanidinoacetate n-methyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471603&form=6&db=m Creatine metabolism in patients with urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Gyrate Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811048&form=6&db=m Induction of arginase II mRNA by nitric oxide using in vitro model of gyrate atrophy of choroid and retina. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25186018&form=6&db=m Increased arginase levels contribute to impaired perfusion after cardiopulmonary resuscitation. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Heart Defects, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32766551&form=6&db=m Derangement of Arginine and Related Amino Acids in Children Undergoing Surgery for Congenital Heart Disease With Cardiopulmonary Bypass. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763290&form=6&db=m Chronic Co-Administration of Sepiapterin and l-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice. causal interaction,unassigned 3,0 3.5.3.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1139781&form=6&db=m Early diagnosis of myocardial infarction by arginase activity determination. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20511413&form=6&db=m Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075998&form=6&db=m Increased arginase levels in heart failure represent a therapeutic target to rescue microvascular perfusion. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417041&form=6&db=m Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25263201&form=6&db=m Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.5.3.1 HELLP Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30604095&form=6&db=m Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity. diagnostic usage,ongoing research,unassigned 2,2,0 3.5.3.1 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24489574&form=6&db=m Immunomodulatory effect of bisphosphonate risedronate sodium on CD163+ arginase 1+ M2 macrophages: the development of a possible supportive therapy for angiosarcoma. ongoing research,therapeutic application,unassigned 1,3,0 3.5.3.1 Hematologic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863373&form=6&db=m [Arginase activity in plasma and erythrocytes in children with hematologic diseases] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.5.3.1 Hemoglobinopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18762165&form=6&db=m Cysteine-iron promotes arginase activity by driving the Fenton reaction. causal interaction,unassigned 4,0 3.5.3.1 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13778980&form=6&db=m Liver arginase activity in patients with liver cirrhosis and in patients in endogenous hepatic coma. diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13840193&form=6&db=m [Hepatic arginase activity in patients in hepatic coma.] diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1424158&form=6&db=m Arginase, a new marker of mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.5.3.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4344396&form=6&db=m Identification of a canine adenovirus (infectious canine hepatitis virus) inhibitor in dog liver extracts as arginase. therapeutic application,unassigned 2,0 3.5.3.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5160572&form=6&db=m [Serum arginase activities in acute hepatitis. 3] causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5597948&form=6&db=m [Significance of determining arginase activity in epidemic hepatitis] causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10520898&form=6&db=m Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.5.3.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14122501&form=6&db=m DETERMINATION OF ARGINASE ACTIVITY IN BLOOD IN EPIDEMIC HEPATITIS. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25616156&form=6&db=m Tumor-induced CD11b(+) Gr-1(+) myeloid-derived suppressor cells exacerbate immune-mediated hepatitis in mice in a CD40-dependent manner. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22475535&form=6&db=m Increased levels of arginase in patients with acute hepatitis B suppress antiviral T cells. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19253371&form=6&db=m Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis. unassigned - 3.5.3.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26826241&form=6&db=m Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-? Production by Altering Cellular Metabolism via Arginase-1. causal interaction,unassigned 1,0 3.5.3.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33328510&form=6&db=m LncRNA HOTAIRM1 promotes MDSC expansion and suppressive functions through the HOXA1-miR124 axis during HCV infection. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33353065&form=6&db=m HCV-Associated Exosomes Upregulate RUNXOR and RUNX1 Expressions to Promote MDSC Expansion and Suppressive Functions through STAT3-miR124 Axis. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hepatitis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10520898&form=6&db=m Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.5.3.1 Hepatitis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10620579&form=6&db=m Enzyme immunoassay for autoantibodies to human liver-type arginase and its clinical application. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 Hepatitis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11750286&form=6&db=m Anti-CYP2D6 antibodies detected by quantitative radioligand assay and relation to antibodies to liver-specific arginase in patients with autoimmune hepatitis. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6473200&form=6&db=m [Usefulness of determining serum arginase in acute and chronic hepatitis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10520898&form=6&db=m Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.5.3.1 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098461&form=6&db=m Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. causal interaction,unassigned 4,0 3.5.3.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=311176&form=6&db=m The significance of the arginine and arginase of tears in experimentally-induced herpes simplex corneae. unassigned - 3.5.3.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983142&form=6&db=m [Polyvinylpyrrolidone iodine and arginase: effect on corneal regeneration and its antiviral effect] therapeutic application,unassigned 2,0 3.5.3.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319272&form=6&db=m Contribution of macrophage arginase in the intrinsic restriction of herpes simplex virus replication in permissive macrophage cultures induced by gamma-interferon containing products of activated spleen cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.5.3.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612622&form=6&db=m CCAAT/enhancer-binding protein beta (C/EBP beta) binds and activates while hepatocyte nuclear factor-4 (HNF-4) does not bind but represses the liver-type arginase promoter. unassigned - 3.5.3.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22222510&form=6&db=m Amniotic Membrane Induces Peroxisome Proliferator-Activated Receptor-? Positive Alternatively Activated Macrophages. unassigned - 3.5.3.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349999&form=6&db=m Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.5.3.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23451288&form=6&db=m Correction: Arginase Activity in the Blood of Patients with Visceral Leishmaniasis and HIV Infection. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29637127&form=6&db=m Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study. ongoing research,unassigned 1,0 3.5.3.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27637084&form=6&db=m The prognostic value of the myeloid-mediated immunosuppression marker Arginase-1 in classic Hodgkin Lymphoma. diagnostic usage,unassigned 4,0 3.5.3.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697592&form=6&db=m Treatment with nerve grafts and aFGF attenuates allodynia caused by cervical root transection injuries. therapeutic application,unassigned 1,0 3.5.3.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403381&form=6&db=m Predictive and Preventive Potential of Preoperative Gut Microbiota in Chronic Postoperative Pain in Breast Cancer Survivors. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=164740&form=6&db=m Unsuccessful trial of gene replacement in arginase deficiency. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=438730&form=6&db=m Arginase and free amino acids in hyperargininemia: leukocyte arginine as a diagnostic parameter for heterozygotes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=481955&form=6&db=m Hyperargininemia with arginase deficiency. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=624188&form=6&db=m Arginase deficiency in multiple tissues in argininemia. causal interaction,unassigned 2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=819629&form=6&db=m Excretion of guanidino-derivates in urine of hyperargininemic patients. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=839368&form=6&db=m Hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=845487&form=6&db=m A simple screening test for arginase deficiency (hyperargininemia). diagnostic usage,therapeutic application,unassigned 3,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=879168&form=6&db=m Human hyperargininemia: a mutation not expressed in skin fibroblasts? causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=890993&form=6&db=m A simple spot-test for the detection of erythrocyte arginase deficiency. diagnostic usage,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=925998&form=6&db=m Influence of arginase deficiency on amino acid concentrations in sheep erythrocytes with a normal and with a defective transport system for amino acids [proceedings] ongoing research,unassigned 2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=990372&form=6&db=m Intravenous loading with arginine-hydrochloride and ornithine-aspartate in siblings of two families, presenting a familial neurological syndrome associated with cystinuria. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1253407&form=6&db=m Use of enzyme-loaded erythrocytes in in-vitro correction of arginase-deficient erythrocytes in familial hyperargininemia. ongoing research,unassigned 2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1404883&form=6&db=m [The dibasic amino acid metabolic disorders] causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1463019&form=6&db=m Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1598908&form=6&db=m Molecular genetic study of human arginase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1959545&form=6&db=m Absence of erythrocyte arginase protein in Japanese patients with hyperargininemia. diagnostic usage,unassigned 2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2291040&form=6&db=m [Late diagnosis of congenital argininemia during administration of sodium valproate] causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2365823&form=6&db=m Molecular basis of argininemia. Identification of two discrete frame-shift deletions in the liver-type arginase gene. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2657590&form=6&db=m Hyperargininemia, epilepsy and the metabolism of guanidino compounds. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2913054&form=6&db=m Differential expression of the two human arginase genes in hyperargininemia. Enzymatic, pathologic, and molecular analysis. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3104676&form=6&db=m A new case of arginase deficiency in a Spanish male. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117587&form=6&db=m Purification, modification, physico-chemical and pharmacokinetic characterization of arginase, an enzyme of potential use in therapy. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3447498&form=6&db=m [Arginase deficiency, congenital hypothyroidism and hepatic fibrosis] causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3540926&form=6&db=m Pteridines and mono-amines: relevance to neurological damage. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3540966&form=6&db=m Molecular cloning and nucleotide sequence of cDNA for human liver arginase. ongoing research,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3632278&form=6&db=m Liver fibrosis in arginase deficiency. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3752085&form=6&db=m The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3760903&form=6&db=m Arginase deficiency and phenylketonuria. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3936352&form=6&db=m Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates. causal interaction,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3943226&form=6&db=m A simple quantitative micromethod of arginase assay in blood spots dried on filter paper. diagnostic usage,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3950825&form=6&db=m Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function. causal interaction,unassigned 2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4078590&form=6&db=m Impaired neurotransmitter amine metabolism in arginase deficiency. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4625814&form=6&db=m Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver. causal interaction,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5438971&form=6&db=m [Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies] unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5438972&form=6&db=m [Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.] unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6404622&form=6&db=m Isoenzyme pattern and immunological properties of arginase in normal and hyperargininemia fibroblasts. ongoing research,unassigned 2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6419196&form=6&db=m Immunologic studies of arginase in tissues of normal human adult and arginase-deficient patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6422160&form=6&db=m A new French-Canadian family affected by hyperargininaemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6468738&form=6&db=m Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6729810&form=6&db=m A successful trial of enzyme replacement therapy in a case of argininemia. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6796772&form=6&db=m Urinary pyrimidine excretion in arginase deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6817948&form=6&db=m Measurement of arginine transport in human erythrocytes using their intrinsic arginase activity: implications for the treatment of familial hyperargininemia. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6820432&form=6&db=m Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet. therapeutic application,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7159597&form=6&db=m Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity. ongoing research,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7261409&form=6&db=m Arginase activity in human fibroblast cultures. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7361766&form=6&db=m Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7389092&form=6&db=m Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7649538&form=6&db=m Molecular basis of phenotypic variation in patients with argininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7717428&form=6&db=m Prenatal diagnosis of the urea cycle diseases: a survey of the European cases. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7967487&form=6&db=m Arginase deficiency presenting with convulsions. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981719&form=6&db=m Identification of mutations (D128G, H141L) in the liver arginase gene of patients with hyperargininemia. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8127062&form=6&db=m Arginase deficiency in two brothers. therapeutic application,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8454280&form=6&db=m Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8474825&form=6&db=m Arginase deficiency presenting as cerebral palsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777806&form=6&db=m [A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta] causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8902193&form=6&db=m Loss of function mutations in conserved regions of the human arginase I gene. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9131018&form=6&db=m Delivery of cytosolic liver arginase into the mitochondrial matrix space: a possible novel site for gene replacement therapy. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295913&form=6&db=m [Proposal for a diet treatment in arginase deficiency] therapeutic application,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9378897&form=6&db=m Argininemia: a treatable genetic cause of progressive spastic diplegia simulating cerebral palsy: case reports and literature review. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9590022&form=6&db=m [Arginase deficiency] unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9608538&form=6&db=m Cloning and characterization of the mouse and rat type II arginase genes. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9686347&form=6&db=m The human arginases and arginase deficiency. ongoing research,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9758714&form=6&db=m Molecular basis of hyperargininemia: structure-function consequences of mutations in human liver arginase. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9762606&form=6&db=m Adult-onset arginase deficiency. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10502833&form=6&db=m Identification of a novel R21X mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771848&form=6&db=m Arginase deficiency. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10947208&form=6&db=m Arginase deficiency presenting with cerebral oedema and failure to thrive. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11148548&form=6&db=m The nutritional management of urea cycle disorders. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11746885&form=6&db=m Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry. diagnostic usage,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11883902&form=6&db=m Functional consequences of the G235R mutation in liver arginase leading to hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12052859&form=6&db=m Mouse model for human arginase deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640389&form=6&db=m Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema. causal interaction,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12718434&form=6&db=m Brain Na+,K(+)-ATPase inhibition induced by arginine administration is prevented by vitamins E and C. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605507&form=6&db=m Prenatal diagnosis for arginase deficiency: a case study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465784&form=6&db=m Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15565656&form=6&db=m Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15694174&form=6&db=m Hyperargininemia due to liver arginase deficiency. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15798789&form=6&db=m Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16233191&form=6&db=m Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16602094&form=6&db=m Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935537&form=6&db=m Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16963300&form=6&db=m A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation. therapeutic application,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513443&form=6&db=m Orotic acid excretion and arginine metabolism. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513445&form=6&db=m Biomarkers identified in inborn errors for lysine, arginine, and ornithine. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17997338&form=6&db=m Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18950360&form=6&db=m Anesthesia in a patient with arginase deficiency: implications and management. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19367256&form=6&db=m Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19936428&form=6&db=m A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004862&form=6&db=m Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304692&form=6&db=m Creatine metabolism and the urea cycle. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20456883&form=6&db=m A long-term survival case of arginase deficiency with severe multicystic white matter and compound mutations. diagnostic usage,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21229317&form=6&db=m Neonatal cholestasis: an uncommon presentation of hyperargininemia. causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21310339&form=6&db=m Argininemia presenting with progressive spastic diplegia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21585399&form=6&db=m Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris. ongoing research,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22633632&form=6&db=m Clinical features and neurologic progression of hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22737599&form=6&db=m SCHEMA Designed Variants of Human Arginase I & II Reveal Sequence Elements Important to Stability and Catalysis. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22760543&form=6&db=m Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22866323&form=6&db=m Argocytes containing enzyme nanoparticles reduce toxic concentrations of arginine in the blood. therapeutic application,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22959135&form=6&db=m Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971419&form=6&db=m Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388701&form=6&db=m AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse. causal interaction,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23430921&form=6&db=m Hyperargininemia: a family with a novel mutation in an unexpected site. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23559324&form=6&db=m Liver transplantation prevents progressive neurological impairment in argininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859858&form=6&db=m Five novel mutations in ARG1 gene in Chinese patients of argininemia. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23920045&form=6&db=m Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24103480&form=6&db=m Novel Complex Re-Arrangement of ARG1 commonly shared by unrelated patients with Hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24224027&form=6&db=m Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24229587&form=6&db=m [Advances in clinical and molecular genetics studies on argininemia]. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24258525&form=6&db=m Epilepsia Partialis Continua and Generalized Nonconvulsive Status Epilepticus during the Course of Argininemia: A Report on Two Cases. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814679&form=6&db=m Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24888478&form=6&db=m Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice. causal interaction,ongoing research,unassigned 2,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25474440&form=6&db=m Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25611620&form=6&db=m Anesthetic management of a patient with arginase deficiency undergoing liver transplantation. therapeutic application,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25938595&form=6&db=m Strategies to rescue the consequences of inducible arginase-1 deficiency in mice. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123990&form=6&db=m Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26310552&form=6&db=m [Seven patients of argininemia with spastic tetraplegia as the first and major symptom and prenatal diagnosis of two fetuses with high risk]. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26358771&form=6&db=m Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27056296&form=6&db=m Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335400&form=6&db=m Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570396&form=6&db=m Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity. therapeutic application,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27663197&form=6&db=m Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study. causal interaction,unassigned 2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27898091&form=6&db=m Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28089752&form=6&db=m Three novel mutations of ARG1 identified in Chinese patients with argininemia detected by newborn screening. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28515179&form=6&db=m Arginase-2 mediates renal ischemia-reperfusion injury. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28566761&form=6&db=m Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659245&form=6&db=m Newborn screening for hyperargininemia due to arginase 1 deficiency. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187023&form=6&db=m Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423830&form=6&db=m Biochemical markers and neuropsychological functioning in distal urea cycle disorders. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29478971&form=6&db=m Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29724658&form=6&db=m Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29726057&form=6&db=m Mutations and common variants in the human arginase 1 (ARG1) gene: Impact on patients, diagnostics, and protein structure considerations. causal interaction,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29768370&form=6&db=m A case report of neurological complications owing to lately diagnosed hyperargininemia emphasizing the role of national neonatal screening policies in the kingdom of Bahrain. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961243&form=6&db=m Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961498&form=6&db=m "Cerebral Palsy" in a Patient With Arginase Deficiency. causal interaction,diagnostic usage,unassigned 3,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30294546&form=6&db=m The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine. therapeutic application,unassigned 1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670878&form=6&db=m Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31484827&form=6&db=m Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31501335&form=6&db=m Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31649772&form=6&db=m Arginase Deficiency Presenting as Acute Encephalopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32025996&form=6&db=m Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32580855&form=6&db=m Hyperargininemic Encephalopathy with Unique Clinical Presentation and Novel Genetic Mutations. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32769929&form=6&db=m A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32770317&form=6&db=m Neurological Deterioration in Three Siblings: Exploring the Spectrum of Argininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193012&form=6&db=m Novel Homozygous Missense Mutation in the ARG1 Gene in a Large Sudanese Family. unassigned - 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33325055&form=6&db=m Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732618&form=6&db=m Arginine to ornithine ratio as a diagnostic marker in patients with positive newborn screening for hyperargininemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995244&form=6&db=m Review of Multi-Modal Imaging in Urea Cycle Disorders: The Old, the New, the Borrowed, and the Blue. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34343381&form=6&db=m Case series of Arginase 1 deficiency: Expanding the spectrum in hyperargininemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34419780&form=6&db=m Spastic gait, intellectual disability and seizures due to a rare mutation causing hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471603&form=6&db=m Creatine metabolism in patients with urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100148568&form=6&db=m Isotropic growth of spores and salt tolerance in Aspergillus nidulans ongoing research,unassigned 2,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11257319&form=6&db=m Inhibition of platelet aggregation by putrescine, spermidine, and spermine in hypercholesterolemic rabbits. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23950140&form=6&db=m Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction: Role of Endothelial Nitric Oxide Synthase and Arginase II. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966996&form=6&db=m Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24612630&form=6&db=m An Increased Arginase Activity Is Associated with Corpus Cavernosum Impairment Induced by Hypercholesterolemia. causal interaction,unassigned 4,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27079229&form=6&db=m Effect of Two Ginger Varieties on Arginase Activity in Hypercholesterolemic Rats. causal interaction,unassigned 1,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28223872&form=6&db=m Chitosan treatment abrogates hypercholesterolemia-induced erythrocyte's arginase activation. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048462&form=6&db=m Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785959&form=6&db=m Improvement in endothelial function in cardiovascular disease - Is arginase the target? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17804300&form=6&db=m Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928367&form=6&db=m Insulin reduces plasma arginase activity in type 2 diabetic patients. causal interaction,unassigned 4,0 3.5.3.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20214019&form=6&db=m Arginase activity and magnesium levels in blood of children with diabetes mellitus. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28835451&form=6&db=m Obesity-induced vascular inflammation involves elevated arginase activity. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 3.5.3.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30151392&form=6&db=m Panax notoginseng Saponins Regulate Macrophage Polarization under Hyperglycemic Condition via NF-?B Signaling Pathway. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31150695&form=6&db=m Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29091892&form=6&db=m Nitric oxide bioavailability dysfunction involves in atherosclerosis. unassigned - 3.5.3.1 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928367&form=6&db=m Insulin reduces plasma arginase activity in type 2 diabetic patients. causal interaction,unassigned 4,0 3.5.3.1 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441715&form=6&db=m Arginase inhibition alleviates hypertension in the metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20981735&form=6&db=m Hyperlipidemic versus healthy pancreases: a proteomic analysis using an animal model. ongoing research,unassigned 1,0 3.5.3.1 Hyperlysinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=904980&form=6&db=m Periodic hyperammonemia, hyperlysinemia, and homocitrullinuria associated with decreased argininosuccinate synthetase and arginase activities. unassigned - 3.5.3.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200399&form=6&db=m Human eosinophil granulocytes do not express the enzyme arginase. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382750&form=6&db=m Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.5.3.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21105863&form=6&db=m Effect of starvation and refeeding on biochemical and immunological status of Balb/c mice: an experimental model of malnutrition. ongoing research,unassigned 2,0 3.5.3.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22915279&form=6&db=m Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060156&form=6&db=m Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese workers. causal interaction,unassigned 1,0 3.5.3.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24710938&form=6&db=m Cyclooxygenase-2 blockade inhibits accumulation and function of myeloid-derived suppressor cells and restores T cell response after traumatic stress. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8691729&form=6&db=m L-arginine depletion inhibits glomerular nitric oxide synthesis and exacerbates rat nephrotoxic nephritis. causal interaction,unassigned 1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10685726&form=6&db=m Increased arginase activity in aorta of mineralocorticoid-salt hypertensive rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059380&form=6&db=m [Disorders of endothelium-dependent vascular reactions and of the arginase and NO-synthase pathways of L-arginine metabolism in arterial hypertension] causal interaction,unassigned 2,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11758464&form=6&db=m [Inhibitors of arginase in the L-arginine metabolic pathway as a new class of antihypertensive drugs: effect of carbamide on lipid oxidative metabolism and on vessel tonus during arterial hypertension] causal interaction,therapeutic application,unassigned 2,3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12125280&form=6&db=m [Effect of irbesartan, an antagonist of AT-1 receptors for angiotensin II, on L-arginine metabolism in arterial hypertension] ongoing research,unassigned 4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12135320&form=6&db=m Decreased expression of arginase II in the kidneys of Dahl salt-sensitive rats. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15000293&form=6&db=m How could aortic arginase activity enhancement be involved in DOCA-salt hypertension? causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15364894&form=6&db=m Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492130&form=6&db=m Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. causal interaction,unassigned 4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15591155&form=6&db=m Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15732754&form=6&db=m [Inhibitors of arginase pathway in L-arginine metabolism as a new class of antihypertensive drugs: action of urea on oxidative and nonoxidative metabolism of L-arginine and vascular tone in chronic hypertension] causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17223136&form=6&db=m Time course of vascular arginase expression and activity in spontaneously hypertensive rats. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645639&form=6&db=m Arginase: a critical regulator of nitric oxide synthesis and vascular function. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18475148&form=6&db=m Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18991648&form=6&db=m Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders. causal interaction,unassigned 4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19546381&form=6&db=m Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687346&form=6&db=m Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763131&form=6&db=m Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19841582&form=6&db=m Regulation of nitric oxide production in health and disease. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20039818&form=6&db=m Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia. causal interaction,unassigned 3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20219858&form=6&db=m Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20699748&form=6&db=m Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock. causal interaction,ongoing research,unassigned 3,2,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861464&form=6&db=m HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20863773&form=6&db=m Experimental studies of OH° radical/pressure dependence of arginase activity using a molecular chromatography approach. causal interaction,unassigned 4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21622244&form=6&db=m Endothelial dysfunction in hypertension: the role of arginase. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21740411&form=6&db=m Oxidative Species Increase Arginase Activity in Endothelial Cells through RhoA/Rho Kinase Pathway. unassigned - 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21962706&form=6&db=m Peculiarities of a novel bioenzymatic reactor using carbon nanotubes as enzyme activity enhancers: application to arginase. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21995824&form=6&db=m Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22117419&form=6&db=m [Arginase, nitrates, and nitrites in the blood plasma and erythrocytes in hypertension and after therapy with lisinopril and simvastatin]. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22281732&form=6&db=m Arginase inhibition alleviates hypertension associated with diabetes: Effect on endothelial dependent relaxation and NO production. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22829869&form=6&db=m Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice. causal interaction,ongoing research,unassigned 3,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417041&form=6&db=m Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441715&form=6&db=m Arginase inhibition alleviates hypertension in the metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717158&form=6&db=m Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling. therapeutic application,unassigned 1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717309&form=6&db=m Role of arginase in vessel wall remodeling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23730303&form=6&db=m Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic rats. causal interaction,unassigned 3,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908657&form=6&db=m Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966996&form=6&db=m Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062745&form=6&db=m Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25490411&form=6&db=m Pulmonary Arterial Hypertension in Rats Due to Age-related Arginase Activation in Intermittent Hypoxia. unassigned - 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557182&form=6&db=m Arginase promotes endothelial dysfunction and hypertension in obese rats. causal interaction,ongoing research,unassigned 3,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26126810&form=6&db=m Arginase inhibition protects against hypoxia?induced pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26608181&form=6&db=m Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27734327&form=6&db=m Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048462&form=6&db=m Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29700652&form=6&db=m Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785959&form=6&db=m Improvement in endothelial function in cardiovascular disease - Is arginase the target? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172062&form=6&db=m Naringin protects against Bisphenol-A induced oculopathy as implication of cataract in hypertensive rat model. unassigned - 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428650&form=6&db=m Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model. unassigned - 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32794232&form=6&db=m Extracts from Almond (Terminalia catappa) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A-stressed rats. ongoing research,unassigned 4,0 3.5.3.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33149269&form=6&db=m Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes? causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7778169&form=6&db=m Arginase release following liver reperfusion. Evidence of hemodynamic action of arginase infusions. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626350&form=6&db=m Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15364894&form=6&db=m Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15998894&form=6&db=m Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17322279&form=6&db=m Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats. causal interaction,ongoing research,unassigned 3,1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897312&form=6&db=m In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437360&form=6&db=m Arginase and pulmonary diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20173047&form=6&db=m Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861464&form=6&db=m HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24324044&form=6&db=m Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways. therapeutic application,unassigned 1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24919409&form=6&db=m Arginase I gene single-nucleotide polymorphism is associated with decreased risk of pulmonary hypertension in bronchopulmonary dysplasia. causal interaction,unassigned 4,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24951775&form=6&db=m Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595650&form=6&db=m Arginase Inhibition Prevents Bleomycin-Induced Pulmonary Hypertension, Vascular Remodeling and Collagen Deposition in Neonatal Rat Lungs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27432976&form=6&db=m HIF2?-arginase axis is essential for the development of pulmonary hypertension. causal interaction,unassigned 3,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27537757&form=6&db=m Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895230&form=6&db=m An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28213467&form=6&db=m Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPK?1 signaling. causal interaction,unassigned 4,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28248201&form=6&db=m Intravascular hemolysis and the pathophysiology of sickle cell disease. causal interaction,unassigned 3,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28757567&form=6&db=m Arginase Inhibition Reverses Monocrotaline-Induced Pulmonary Hypertension. causal interaction,therapeutic application,unassigned 2,2,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29472234&form=6&db=m Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896110&form=6&db=m Plasmatic Concentrations of ADMA and Homocystein in Llama (Lama glama) and Regulation of Arginase Type II: An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia. diagnostic usage,ongoing research,unassigned 2,4,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30267614&form=6&db=m Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833679&form=6&db=m Arginine Therapy for Lung Diseases. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33948161&form=6&db=m L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.5.3.1 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5712375&form=6&db=m [Inhibition with ethionine and puromycin of the increase of hepatic arginase and urea excretion in hyperthyroid rats] causal interaction,unassigned 1,0 3.5.3.1 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7215333&form=6&db=m Regulation of pathways of ornithine metabolism. Effects of thyroid hormone and diabetes on the activity of enzymes at the "ornithine crossroads' in rat liver. unassigned - 3.5.3.1 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907224&form=6&db=m Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26674221&form=6&db=m l-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats. ongoing research,unassigned 1,0 3.5.3.1 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441715&form=6&db=m Arginase inhibition alleviates hypertension in the metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563530&form=6&db=m Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Hypoxia-Ischemia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30995639&form=6&db=m The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia. unassigned - 3.5.3.1 Hypoxia-Ischemia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32464635&form=6&db=m Changes in arginase isoforms in a murine model of neonatal brain hypoxia-ischemia. ongoing research,unassigned 2,0 3.5.3.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934065&form=6&db=m Functional role and species-specific contribution of arginases in pulmonary fibrosis. causal interaction,ongoing research,unassigned 2,2,0 3.5.3.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437360&form=6&db=m Arginase and pulmonary diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.5.3.1 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354980&form=6&db=m Small-molecule arginase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29600431&form=6&db=m Effectiveness of arginase inhibitors against experimentally induced stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1905984&form=6&db=m Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates. therapeutic application,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2860832&form=6&db=m Diagnosis of Fasciola hepatica infection in beef calves by plasma enzyme analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6150530&form=6&db=m Serum gamma glutamyl transpeptidase activity in cattle with induced fascioliasis. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9097840&form=6&db=m Effects of alpha-adrenergic agonists on Toxoplasma gondii replication in human umbilical vein endothelial cells. therapeutic application,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9413508&form=6&db=m Anti-MHV3 state induced by IFN gamma in macrophages is not related to arginine metabolism. ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10839490&form=6&db=m A potential role for arginase in recurrent infections and hypertrophy of tonsillar and adenoidal tissue. causal interaction,unassigned 4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899869&form=6&db=m L-Arginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11172921&form=6&db=m Induction of arginases I and II in cornea during herpes simplex virus infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11257143&form=6&db=m The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920566&form=6&db=m Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite. causal interaction,therapeutic application,unassigned 1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11982856&form=6&db=m Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13793004&form=6&db=m [Metabolic aspects of hepatic tissue in infection of the mouse from EDP virus. II. Transaminase and arginase activity.] ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15128819&form=6&db=m Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15187136&form=6&db=m Enhancer-mediated control of macrophage-specific arginase I expression. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210820&form=6&db=m Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta). causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265947&form=6&db=m Protective role of arginase in a mouse model of colitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322128&form=6&db=m Regulation of plant arginase by wounding, jasmonate, and the phytotoxin coronatine. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15367297&form=6&db=m A non-classical type of alveolar macrophage response to Trichinella spiralis infection. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15528222&form=6&db=m High dissemination and hepatotoxicity in rats infected with Candida albicans after stress exposure: potential sensitization to liver damage. diagnostic usage,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15711216&form=6&db=m Immunonutrition. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15811879&form=6&db=m Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15832677&form=6&db=m Glycoproteins from sugarcane plants regulate cell polarity of Ustilago scitaminea teliospores. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879104&form=6&db=m Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection. ongoing research,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16097891&form=6&db=m Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma. diagnostic usage,unassigned 4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113329&form=6&db=m Arginase I induction during Leishmania major infection mediates the development of disease. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16218877&form=6&db=m Impact of Mycoplasma hyorhinis infection on L-arginine metabolism: differential regulation of the human and murine iNOS gene. ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16629702&form=6&db=m Immunohistological features of visceral leishmaniasis in BALB/c mice. ongoing research,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16684608&form=6&db=m Differential macrophage polarisation during parasitic infections in common carp (Cyprinus carpio L.). diagnostic usage,therapeutic application,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788192&form=6&db=m Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection. diagnostic usage,therapeutic application,unassigned 1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015747&form=6&db=m Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101652&form=6&db=m Differential liver protein expression during schistosomiasis. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17374847&form=6&db=m MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae. causal interaction,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513447&form=6&db=m Arginine and immunity. causal interaction,unassigned 4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513466&form=6&db=m Virulence mechanisms of coccidioides. causal interaction,ongoing research,unassigned 3,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18034422&form=6&db=m TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis. causal interaction,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056391&form=6&db=m An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18305204&form=6&db=m Differential regulation of root arginine catabolism and polyamine metabolism in clubroot-susceptible and partially resistant Arabidopsis genotypes. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18422071&form=6&db=m [Macrophages and arginase induction as a mechanism for parasite escape] diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18426884&form=6&db=m The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo. causal interaction,ongoing research,unassigned 2,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473687&form=6&db=m Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18625332&form=6&db=m Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19008964&form=6&db=m Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19033672&form=6&db=m Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19284495&form=6&db=m Susceptibility to Yersinia pseudotuberculosis infection is linked to the pattern of macrophage activation. ongoing research,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456233&form=6&db=m Alternatively activated and immunoregulatory monocytes in human filarial infections. diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19923451&form=6&db=m Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20044996&form=6&db=m In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20056835&form=6&db=m Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200236&form=6&db=m Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis. causal interaction,unassigned 4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200399&form=6&db=m Human eosinophil granulocytes do not express the enzyme arginase. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20451229&form=6&db=m Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20527960&form=6&db=m Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection . causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20585552&form=6&db=m Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulator. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861464&form=6&db=m HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21051863&form=6&db=m Rat models to investigate host macrophage defense against Trypanosoma cruzi. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21085614&form=6&db=m MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21246055&form=6&db=m Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. therapeutic application,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21303364&form=6&db=m Programmed death ligand 2 regulates arginase induction and modifies Trypanosoma cruzi survival in macrophages during murine experimental infection. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21413004&form=6&db=m Expression of IL-10-triggered STAT3-dependent IL-4R? is required for induction of arginase 1 in visceral leishmaniasis. causal interaction,ongoing research,unassigned 3,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21482681&form=6&db=m Increased disease severity of parasite-infected TLR2-/- mice is correlated with decreased central nervous system inflammation and reduced numbers of cells with alternatively activated macrophage phenotypes in a murine model of neurocysticercosis. causal interaction,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21525381&form=6&db=m Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. causal interaction,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21585399&form=6&db=m Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris. ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21804013&form=6&db=m Myeloid-Derived Suppressor Cells Infiltrate the Heart in Acute Trypanosoma cruzi Infection. causal interaction,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21931552&form=6&db=m Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22033378&form=6&db=m Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22110379&form=6&db=m The increase in mannose receptor recycling favors arginase induction and Trypanosoma cruzi survival in macrophages. causal interaction,unassigned 4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22188168&form=6&db=m Overexpression of arginase in Arabidopsis thaliana influences defence responses against Botrytis cinerea. ongoing research,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22261576&form=6&db=m Arginine decreases Cryptosporidium parvum infection in undernourished suckling mice involving nitric oxide synthase and arginase. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22271269&form=6&db=m Effect of the Mammalian Arginase Inhibitor 2(S)-Amino-6-Boronohexanoic Acid on Bacillus anthracis Arginase. causal interaction,therapeutic application,unassigned 1,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22415264&form=6&db=m Kinetoplastid membrane protein-11 exacerbates infection with Leishmania amazonensis in murine macrophages. ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22433460&form=6&db=m Arginase induction represses gall development during clubroot infection in Arabidopsis. causal interaction,ongoing research,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22558235&form=6&db=m Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22851746&form=6&db=m Type 2 Innate Immunity in Helminth Infection Is Induced Redundantly and Acts Autonomously following CD11c+ Cell Depletion. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22876751&form=6&db=m Mitigating an undesirable immune response of inherent susceptibility to cutaneous leishmaniosis in a mouse model: the role of the pathoantigenic HISA70 DNA vaccine. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22972923&form=6&db=m Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152844&form=6&db=m IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction. ongoing research,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23460745&form=6&db=m Parasite-Derived Arginase Influences Secondary Anti-Leishmania Immunity by Regulating Programmed Cell Death-1-Mediated CD4+ T Cell Exhaustion. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23470573&form=6&db=m The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury. ongoing research,therapeutic application,unassigned 4,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542635&form=6&db=m Studies on the arginase, 5'-nucleotidase and lysozyme activity by monocytes from visceral leishmaniasis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23691079&form=6&db=m Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23870955&form=6&db=m Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection. ongoing research,therapeutic application,unassigned 1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966857&form=6&db=m MAP Kinase Phosphatase-2 Plays a Key Role in the Control of Infection with Toxoplasma gondii by Modulating iNOS and Arginase-1 Activities in Mice. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24043899&form=6&db=m RON Receptor Tyrosine Kinase, a Negative Regulator of Inflammation, Is Decreased during Simian Immunodeficiency Virus-Associated Central Nervous System Disease. causal interaction,diagnostic usage,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24086125&form=6&db=m Correction: MAP Kinase Phosphatase-2 Plays a Key Role in the Control of Infection with Toxoplasma gondii by Modulating iNOS and Arginase-1 Activities in Mice. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24090570&form=6&db=m Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24102495&form=6&db=m Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice. ongoing research,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204274&form=6&db=m A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. therapeutic application,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595185&form=6&db=m Effect of arginase inhibition on pulmonary L-arginine metabolism in murine pseudomonas pneumonia. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24913050&form=6&db=m Treatment of Amaranthus cruentus with chemical and biological inducers of resistance has contrasting effects on fitness and protection against compatible Gram positive and Gram negative bacterial pathogens. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925982&form=6&db=m Lung arginase expression and activity is increased in cystic fibrosis mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25030421&form=6&db=m Aberrant host defense against Leishmania major in the absence of SLPI. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25084831&form=6&db=m Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122115&form=6&db=m Transcriptome of American oysters, Crassostrea virginica, in response to bacterial challenge: insights into potential mechanisms of disease resistance. causal interaction,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25177109&form=6&db=m Multitracer stable isotope quantification of arginase and nitric oxide synthase activity in a mouse model of pseudomonas lung infection. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25188587&form=6&db=m First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25376381&form=6&db=m Characterisation of the ex vivo virulence of Leishmania infantum isolates from Phlebotomus perniciosus from an outbreak of human leishmaniosis in Madrid, Spain. ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25541383&form=6&db=m Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25601495&form=6&db=m Lysophosphatidylcholine exacerbates Leishmania major-dendritic cell infection through interleukin-10 and a burst in arginase1 and indoleamine 2,3-dioxygenase activities. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789453&form=6&db=m Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25797399&form=6&db=m Macrophages expressing arginase 1 and nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26119192&form=6&db=m Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26169275&form=6&db=m Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26297234&form=6&db=m Susceptibility of bone marrow derived macrophages to influenza virus infection is dependent on macrophage phenotype. diagnostic usage,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26311904&form=6&db=m Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity. ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26471500&form=6&db=m Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26528287&form=6&db=m Kinetoplastid Membrane Protein-11 as a Vaccine Candidate and a Virulence Factor in Leishmania. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27032691&form=6&db=m The first description of complete invertebrate arginine metabolism pathways implies dose-dependent pathogen regulation in Apostichopus japonicus. therapeutic application,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27074721&form=6&db=m Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27117406&form=6&db=m TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection. ongoing research,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27474745&form=6&db=m Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism. ongoing research,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27558349&form=6&db=m A nanobiosensor for the detection of arginase activity. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27581741&form=6&db=m Recombinant IL-4/13A and IL-4/13B induce arginase activity and down-regulate nitric oxide response of primary goldfish (Carassius auratus L.) macrophages. causal interaction,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27795357&form=6&db=m Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28025160&form=6&db=m Characterisation of arginase paralogues in salmonids and their modulation by immune stimulation/ infection. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28276497&form=6&db=m Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism. ongoing research,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28462680&form=6&db=m Does placental MDSC-mediated modulation of arginine levels help protect the foetus from auxotrophic pathogens? therapeutic application,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28545808&form=6&db=m The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28545810&form=6&db=m Thymic stromal lymphopoietin and apocynin alter the expression of airway remodeling factors in human rhinovirus-infected cells. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28558034&form=6&db=m MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBP? regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28739879&form=6&db=m Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28835242&form=6&db=m Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8(+) T cell responses during acute Friend retrovirus infection. diagnostic usage,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28915996&form=6&db=m Alternative strategy for visceral leishmaniosis control: HisAK70-Salmonella Choleraesuis-pulsed dendritic cells. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28956486&form=6&db=m Evaluation of arginase activity, nitric oxide and oxidative stress status in sheep with contagious agalactia. ongoing research,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29201027&form=6&db=m l-Citrulline Metabolism in Mice Augments CD4 unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29327047&form=6&db=m Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities: Secondary Analysis of a Randomized Clinical Trial. ongoing research,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29661929&form=6&db=m Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108583&form=6&db=m Galectin-3 and Galectin-9 May Differently Regulate the Expressions of Microglial M1/M2 Markers and T Helper 1/Th2 Cytokines in the Brains of Genetically Susceptible C57BL/6 and Resistant BALB/c Mice Following Peroral Infection With Toxoplasma gondii. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30120920&form=6&db=m [Expression and Activity of Arginase from Monocytic-type Myeloid-derived Suppressor Cells in Rats Infected with Echinococcus granulosus]. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30142466&form=6&db=m Decidual macrophage M1 polarization contributes to adverse pregnancy induced by Toxoplasma gondii PRU strain infection. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232226&form=6&db=m Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome. causal interaction,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30248443&form=6&db=m Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30520685&form=6&db=m Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30555475&form=6&db=m Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection. therapeutic application,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30555476&form=6&db=m Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31175971&form=6&db=m An overview of the immune response and Arginase I on CHIKV immunopathogenesis. causal interaction,unassigned 4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31177351&form=6&db=m Nitric oxide production is downregulated during respiratory syncytial virus persistence by constitutive expression of arginase 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31572687&form=6&db=m Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708913&form=6&db=m Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31835767&form=6&db=m Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31923400&form=6&db=m Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004621&form=6&db=m Signaling pathways that regulate Trypanosoma cruzi infection and immune response. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32049381&form=6&db=m Role of l-arginine and CD11b+Gr-1+ cells in immunosuppression induced by Heligmosomoides polygyrus bakeri. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32231658&form=6&db=m Galectins, Eosinophiles, and Macrophages May Contribute to Schistosoma japonicum Egg-Induced Immunopathology in a Mouse Model. diagnostic usage,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32312763&form=6&db=m Differential Regulation of l-Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32477357&form=6&db=m RANK Ligand Helps Immunity to Leishmania major by Skewing M2-Like Into M1 Macrophages. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32582303&form=6&db=m Neutrophils, Crucial, or Harmful Immune Cells Involved in Coronavirus Infection: A Bioinformatics Study. causal interaction,unassigned 2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32886592&form=6&db=m Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33155730&form=6&db=m Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors. causal interaction,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33194814&form=6&db=m Leishmania amazonensis Promastigotes or Extracellular Vesicles Modulate B-1 Cell Activation and Differentiation. causal interaction,unassigned 3,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33298174&form=6&db=m DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4?+?T cells in response to SIV infections. unassigned - 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33353065&form=6&db=m HCV-Associated Exosomes Upregulate RUNXOR and RUNX1 Expressions to Promote MDSC Expansion and Suppressive Functions through STAT3-miR124 Axis. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414508&form=6&db=m Vagal-?7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34206906&form=6&db=m Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection with L. amazonensis. causal interaction,unassigned 1,0 3.5.3.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34523355&form=6&db=m ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.5.3.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10732690&form=6&db=m Seminal arginase activity in infertility. diagnostic usage,unassigned 1,0 3.5.3.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30581349&form=6&db=m Alterations in Arginase-NO-synthase System of Spermatozoa in Human Subjects with Different Fertility Potential. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12792224&form=6&db=m Nitric oxide in inflammatory bowel disease. causal interaction,unassigned 4,0 3.5.3.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17218473&form=6&db=m Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354980&form=6&db=m Small-molecule arginase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414508&form=6&db=m Vagal-?7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23130157&form=6&db=m Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. unassigned - 3.5.3.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441715&form=6&db=m Arginase inhibition alleviates hypertension in the metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23872146&form=6&db=m CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues. unassigned - 3.5.3.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26840628&form=6&db=m ADMA elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbid obese humans. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29700652&form=6&db=m Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29753026&form=6&db=m Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide. ongoing research,unassigned 2,0 3.5.3.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31622373&form=6&db=m Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6729810&form=6&db=m A successful trial of enzyme replacement therapy in a case of argininemia. causal interaction,unassigned 3,0 3.5.3.1 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16963300&form=6&db=m A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation. therapeutic application,unassigned 3,0 3.5.3.1 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26358771&form=6&db=m Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335400&form=6&db=m Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. causal interaction,unassigned 4,0 3.5.3.1 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31484827&form=6&db=m Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Intestinal Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25135690&form=6&db=m Arginine Supplementation Induces Arginase Activity and Inhibits TNF-? Synthesis in Mice Spleen Macrophages After Intestinal Obstruction. ongoing research,therapeutic application,unassigned 4,2,0 3.5.3.1 Iron Deficiencies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32185135&form=6&db=m Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712794&form=6&db=m Pulmonary hypertension in thalassemia. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19523030&form=6&db=m Arginase, NOS activities, and clinical features in fibromyalgia patients. causal interaction,diagnostic usage,unassigned 1,4,0 3.5.3.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23311438&form=6&db=m Effect of stroke on arginase expression and localization in the rat brain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.5.3.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515089&form=6&db=m The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28248201&form=6&db=m Intravascular hemolysis and the pathophysiology of sickle cell disease. causal interaction,unassigned 3,0 3.5.3.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29600431&form=6&db=m Effectiveness of arginase inhibitors against experimentally induced stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30112629&form=6&db=m Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.5.3.1 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11172921&form=6&db=m Induction of arginases I and II in cornea during herpes simplex virus infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27783156&form=6&db=m Arginase activity, urea, and hydroxyproline concentration are reduced in keratoconus keratocytes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.5.3.1 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31600816&form=6&db=m [Increased NF-?B and iNOS Expression in Keratoconus Keratocytes - Hints for an Inflammatory Component?] diagnostic usage,ongoing research,unassigned 1,3,0 3.5.3.1 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13259919&form=6&db=m [Arginase activity of the kidney in some experimental kidney diseases.] ongoing research,therapeutic application,unassigned 4,2,0 3.5.3.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=720473&form=6&db=m Effect of experimental chronic renal failure upon the production of urea, as measured by the liver arginase activity in rats. ongoing research,unassigned 3,0 3.5.3.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11434357&form=6&db=m Erythrocyte nitric oxide metabolism in patients with chronic renal failure. ongoing research,unassigned 2,0 3.5.3.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12195395&form=6&db=m [Progression of chronic renal failure in remnant rats: role of arginase inhibition] causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809898&form=6&db=m Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232209&form=6&db=m Impact of transplantation on neutrophil extracellular trap formation in patients with end-stage renal disease: A single-center, prospective cohort study. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Kyphosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20505827&form=6&db=m Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10918219&form=6&db=m Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28248201&form=6&db=m Intravascular hemolysis and the pathophysiology of sickle cell disease. causal interaction,unassigned 3,0 3.5.3.1 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32458472&form=6&db=m A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34036562&form=6&db=m CORRIGENDUM: A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer. causal interaction,ongoing research,unassigned 3,1,0 3.5.3.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797936&form=6&db=m Immunohistochemical study of arginase in cancer of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797936&form=6&db=m Immunohistochemical study of arginase in cancer of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11257143&form=6&db=m The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11378016&form=6&db=m Th1/Th2-regulated arginase availability modulates Leishmania infection. therapeutic application,unassigned 1,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11982856&form=6&db=m Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15811879&form=6&db=m Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113329&form=6&db=m Arginase I induction during Leishmania major infection mediates the development of disease. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18400316&form=6&db=m Biochemical and biophysical properties of a highly active recombinant arginase from Leishmania (Leishmania) amazonensis and subcellular localization of native enzyme. therapeutic application,unassigned 4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18478052&form=6&db=m Age-related alteration of arginase activity impacts on severity of leishmaniasis. ongoing research,unassigned 1,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19637195&form=6&db=m L-arginine deprivation impairs Leishmania major-specific T-cell responses. causal interaction,unassigned 3,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20451229&form=6&db=m Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22033378&form=6&db=m Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327179&form=6&db=m The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase. therapeutic application,unassigned 3,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23583962&form=6&db=m Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. ongoing research,therapeutic application,unassigned 2,4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24264242&form=6&db=m Arginase in leishmania. unassigned - 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25769972&form=6&db=m Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review. therapeutic application,unassigned 1,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25845502&form=6&db=m Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963565&form=6&db=m The Promise of Plant-Derived Substances as Inhibitors of Arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050264&form=6&db=m Crystal structures of Leishmania mexicana arginase complexed with ?,?-disubstituted boronic amino-acid inhibitors. therapeutic application,unassigned 4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27096224&form=6&db=m Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164067&form=6&db=m Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28798743&form=6&db=m l-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis. unassigned - 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30241850&form=6&db=m Inhibition of Leishmania amazonensis arginase by fucogalactan isolated from Agrocybe aegerita mushroom. therapeutic application,unassigned 4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30831225&form=6&db=m Molecular characterization of recombinant arginase of Leishmania donovani. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31134235&form=6&db=m Dietary polyphenols rutin, taxifolin and quercetin related compounds target Leishmania amazonensis arginase. therapeutic application,unassigned 4,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31835767&form=6&db=m Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32294247&form=6&db=m Arginase and its mechanisms in Leishmania persistence. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32312763&form=6&db=m Differential Regulation of l-Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32827854&form=6&db=m Residue-Specific Message Encoding in CD40-Ligand. therapeutic application,unassigned 1,0 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056391&form=6&db=m An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21413004&form=6&db=m Expression of IL-10-triggered STAT3-dependent IL-4R? is required for induction of arginase 1 in visceral leishmaniasis. causal interaction,ongoing research,unassigned 3,3,0 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22720104&form=6&db=m Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124926&form=6&db=m Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27439742&form=6&db=m Comparing acute and chronic human cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica focusing on arginase activity. ongoing research,unassigned 4,0 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28731592&form=6&db=m Arginase activity of Leishmania isolated from patients with cutaneous leishmaniasis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30399441&form=6&db=m Differential expression of TLRs 2, 4, 9, iNOS and TNF-? and arginase activity in peripheral blood monocytes from glucantime unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis caused by Leishmania tropica. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Leishmaniasis, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30665936&form=6&db=m Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1. unassigned - 3.5.3.1 Leishmaniasis, Diffuse Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124926&form=6&db=m Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.5.3.1 Leishmaniasis, Diffuse Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32312763&form=6&db=m Differential Regulation of l-Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21413004&form=6&db=m Expression of IL-10-triggered STAT3-dependent IL-4R? is required for induction of arginase 1 in visceral leishmaniasis. causal interaction,ongoing research,unassigned 3,3,0 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22275864&form=6&db=m Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression. unassigned - 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349999&form=6&db=m Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23451288&form=6&db=m Correction: Arginase Activity in the Blood of Patients with Visceral Leishmaniasis and HIV Infection. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542635&form=6&db=m Studies on the arginase, 5'-nucleotidase and lysozyme activity by monocytes from visceral leishmaniasis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23556019&form=6&db=m Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. diagnostic usage,unassigned 4,0 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24967908&form=6&db=m Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31124384&form=6&db=m Leishmania infantum arginase: biochemical characterization and inhibition by naturally occurring phenolic substances. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33680983&form=6&db=m IL-10 and TGF-? Induced Arginase Expression Contributes to Deficient Nitric Oxide Response in Human Visceral Leishmaniasis. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2397940&form=6&db=m Lymphocyte arginase activity in leprosy--a preliminary report. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.5.3.1 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26827741&form=6&db=m In situ expression of M2 macrophage subpopulation in leprosy skin lesions. therapeutic application,unassigned 1,0 3.5.3.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6488153&form=6&db=m Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6933000&form=6&db=m Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19439212&form=6&db=m Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 3.5.3.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908439&form=6&db=m Arginase-mediated "field" defects in AML. therapeutic application,unassigned 3,0 3.5.3.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26643895&form=6&db=m Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.5.3.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28690100&form=6&db=m Arginase purified from endophytic Pseudomonas aeruginosa IH2: Induce apoptosis through both cell cycle arrest and MMP loss in human leukemic HL-60 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.5.3.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29227812&form=6&db=m Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia. causal interaction,unassigned 2,0 3.5.3.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935537&form=6&db=m Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=240702&form=6&db=m Purification of arginases from human-leukemic lymphocytes and granulocytes: study of their physicochemical and kinetic properties. causal interaction,unassigned 3,0 3.5.3.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8372547&form=6&db=m Arginase activity alterations in peripheral blood lymphocytes in the human chronic lymphocytic leukemia. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=240702&form=6&db=m Purification of arginases from human-leukemic lymphocytes and granulocytes: study of their physicochemical and kinetic properties. causal interaction,unassigned 3,0 3.5.3.1 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6956528&form=6&db=m Modification by serum of differentiation of cultured human myeloid leukemia cells in response to 12-O-tetradecanoylphorbol-13-acetate. diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31088266&form=6&db=m Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 3.5.3.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908439&form=6&db=m Arginase-mediated "field" defects in AML. therapeutic application,unassigned 3,0 3.5.3.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24018014&form=6&db=m Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells. ongoing research,unassigned 4,0 3.5.3.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28464918&form=6&db=m Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. ongoing research,therapeutic application,unassigned 2,3,0 3.5.3.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155941&form=6&db=m Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Leukemia, Myelomonocytic, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29227812&form=6&db=m Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia. causal interaction,unassigned 2,0 3.5.3.1 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22926702&form=6&db=m Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,2 3.5.3.1 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998825&form=6&db=m Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis. causal interaction,unassigned 4,0 3.5.3.1 Leukodystrophy, Globoid Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777806&form=6&db=m [A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta] causal interaction,unassigned 3,0 3.5.3.1 Leukodystrophy, Metachromatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777806&form=6&db=m [A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta] causal interaction,unassigned 3,0 3.5.3.1 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19590038&form=6&db=m Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23840196&form=6&db=m Arginase as a mediator of diabetic retinopathy. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 3.5.3.1 Liver Abscess, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29420539&form=6&db=m Characteristics of inflammatory reactions during development of liver abscess in hamsters inoculated with Entamoeba nuttalli. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3632278&form=6&db=m Liver fibrosis in arginase deficiency. causal interaction,unassigned 4,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4584848&form=6&db=m [Study of ureogenesis in liver cirrhosis by determination of ornithine carbamoyl- transferase and arginase activity in hepatic biopsy specimens] diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5015509&form=6&db=m [Activity of serum arginase in liver cirrhosis. Its special study in the hemorrhagic syndrome and cirrhogenic encephalopathies] ongoing research,unassigned 2,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11931836&form=6&db=m Induction of arginase II in livers of bile duct-ligated rats. causal interaction,unassigned 4,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13778980&form=6&db=m Liver arginase activity in patients with liver cirrhosis and in patients in endogenous hepatic coma. diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17966882&form=6&db=m [Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19636440&form=6&db=m Arginase isoenzymes in human cirrhotic liver. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24713397&form=6&db=m Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,4,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123990&form=6&db=m Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481270&form=6&db=m miR-21-regulated M2 polarization of macrophage is involved in arsenicosis-induced hepatic fibrosis through the activation of hepatic stellate cells. unassigned - 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=35582&form=6&db=m The effect of thioacetamide on urea cycle enzymes of rat liver. unassigned - 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=180720&form=6&db=m [Arginase and carbamyl phosphate synthase activities in chronic liver diseases] causal interaction,unassigned 1,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1424158&form=6&db=m Arginase, a new marker of mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3882282&form=6&db=m Occurrence of cytotoxic autoantibody in rabbits by immunization with heterologous liver arginase: a possible implication in the mechanism of the autoimmune liver diseases. causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4663759&form=6&db=m [Enzyme determination by radiochemical methods: serum arginase and its clinical use in liver diseases] ongoing research,unassigned 3,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5023366&form=6&db=m [Arginase activity in cardiopulmonary diseases. Value of its study in statistic liver diseases] diagnostic usage,unassigned 3,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10520898&form=6&db=m Autoantibody to the liver arginase present in sera of patients with autoimmune hepatitis and chronic hepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11676974&form=6&db=m A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14098784&form=6&db=m [EXPLORATION OF ARGINASE ACTIVITY IN THE COURSE OF LIVER DISEASES, TUMORS AND INCLUSIVE.] unassigned - 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17966882&form=6&db=m [Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103580&form=6&db=m Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity. ongoing research,unassigned 3,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20593143&form=6&db=m Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. ongoing research,unassigned 1,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21229317&form=6&db=m Neonatal cholestasis: an uncommon presentation of hyperargininemia. causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24713397&form=6&db=m Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,4,0 3.5.3.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33669265&form=6&db=m Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699819&form=6&db=m The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase. ongoing research,unassigned 2,0 3.5.3.1 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961243&form=6&db=m Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123990&form=6&db=m Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=819169&form=6&db=m [Inhibitory effect of ellipticine (dimethyl-5,11-(6H) pyrido (4,3-b) carbazole on the induction of liver cancer by BT6 (N,N-dimethyl-p-(benzothiazolylazo) analine) and its effect on the levels of cytochrome P450 and arginase activity] ongoing research,unassigned 2,0 3.5.3.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19374748&form=6&db=m Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC). diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 3.5.3.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28109867&form=6&db=m Interactions between interleukin-6 and myeloid-derived suppressor cells drive the chemoresistant phenotype of hepatocellular cancer. ongoing research,unassigned 2,0 3.5.3.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32118719&form=6&db=m The significance of arginase-1 expression in the diagnosis of liver cancer: A protocol for a systematic review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9868039&form=6&db=m [Study of arginase activity in alveolar macrophages from patients with lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166623&form=6&db=m Increased arginase activity in cystic fibrosis airways. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16257997&form=6&db=m Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17365572&form=6&db=m Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437360&form=6&db=m Arginase and pulmonary diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21271567&form=6&db=m Increased expression of arginase I and II in allergic nasal mucosa. causal interaction,unassigned 4,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21623460&form=6&db=m Asthma in sickle cell disease. causal interaction,unassigned 4,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071598&form=6&db=m L-ornithine derived polyamines in cystic fibrosis airways. causal interaction,unassigned 4,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23535741&form=6&db=m Method development and validation for rat serum fingerprinting with CE-MS: application to ventilator-induced-lung-injury study. therapeutic application,unassigned 1,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925982&form=6&db=m Lung arginase expression and activity is increased in cystic fibrosis mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833679&form=6&db=m Arginine Therapy for Lung Diseases. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9688940&form=6&db=m Induction of arginase isoforms in the lung during hyperoxia. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595650&form=6&db=m Arginase Inhibition Prevents Bleomycin-Induced Pulmonary Hypertension, Vascular Remodeling and Collagen Deposition in Neonatal Rat Lungs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26415531&form=6&db=m The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28496412&form=6&db=m Nitric Oxide Synthase Activity Correlates with OGG1 in Ozone-Induced Lung Injury Animal Models. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278710&form=6&db=m Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9868039&form=6&db=m [Study of arginase activity in alveolar macrophages from patients with lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786901&form=6&db=m A potential role for nitric oxide pathway in tuberculous pleural effusion. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833831&form=6&db=m Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528866&form=6&db=m Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19414774&form=6&db=m Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. ongoing research,unassigned 4,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19431148&form=6&db=m IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer. unassigned - 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26111447&form=6&db=m Thymosin ?1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1. unassigned - 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30026840&form=6&db=m LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer. ongoing research,unassigned 4,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155941&form=6&db=m Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30808864&form=6&db=m Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31008530&form=6&db=m CARD9 prevents lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427725&form=6&db=m Contactin 1 modulates pegylated arginase resistance in small cell lung cancer through induction of epithelial-mesenchymal transition. therapeutic application,unassigned 1,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552680&form=6&db=m Key genes and pathways in tumor-educated dendritic cells by bioinformatical analysis. unassigned - 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33717204&form=6&db=m TRAF6 Regulates the Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Tumor-Bearing Host. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131176&form=6&db=m Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,3 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34344457&form=6&db=m The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.5.3.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393062&form=6&db=m Arginase Pathway Markers of Immune-Microenvironment in Thymic Epithelial Tumors and Small Cell Lung Cancer. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11593962&form=6&db=m Arginase levels are increased in patients with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.5.3.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=633392&form=6&db=m Tissue enzyme changes in parabiotic rats with subcutaneous lymphoma or fibrosarcoma. diagnostic usage,unassigned 3,0 3.5.3.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23365669&form=6&db=m Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.5.3.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28411578&form=6&db=m Differential effects of low-dose fludarabine or 5-fluorouracil on the tumor growth and myeloid derived immunosuppression status of tumor-bearing mice. therapeutic application,unassigned 1,0 3.5.3.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578463&form=6&db=m Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Lymphoma, B-Cell, Marginal Zone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32063899&form=6&db=m Myeloid-Derived Suppressor Cells and ??T17 Cells Contribute to the Development of Gastric MALT Lymphoma in H. felis-Infected Mice. diagnostic usage,unassigned 3,0 3.5.3.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24113174&form=6&db=m Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin's lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636145&form=6&db=m CD14(+) HLA-DR low/(-) monocytes as indicator of disease aggressiveness in B-cell non-Hodgkin lymphoma. diagnostic usage,ongoing research,unassigned 2,3,0 3.5.3.1 Lymphopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33387156&form=6&db=m SARS-CoV-2-Induced ARDS Associates with MDSC Expansion, Lymphocyte Dysfunction, and Arginine Shortage. unassigned - 3.5.3.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15843155&form=6&db=m Structural metal dependency of the arginase from the human malaria parasite Plasmodium falciparum. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18725795&form=6&db=m Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218089&form=6&db=m Host-parasite interactions revealed by Plasmodium falciparum metabolomics. ongoing research,unassigned 4,0 3.5.3.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20662718&form=6&db=m Increased pulmonary pressures and myocardial wall stress in children with severe malaria. diagnostic usage,unassigned 2,0 3.5.3.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24620026&form=6&db=m Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385484&form=6&db=m Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity. diagnostic usage,unassigned 2,0 3.5.3.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27923948&form=6&db=m Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria. diagnostic usage,ongoing research,unassigned 1,1,0 3.5.3.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456858&form=6&db=m The activity of Plasmodium falciparum arginase is mediated by a novel inter-monomer salt-bridge between Glu295-Arg404. causal interaction,unassigned 3,0 3.5.3.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20527960&form=6&db=m Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection . causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21728378&form=6&db=m Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design. causal interaction,unassigned 3,0 3.5.3.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27923948&form=6&db=m Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria. diagnostic usage,ongoing research,unassigned 1,1,0 3.5.3.1 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=523984&form=6&db=m Studies of renal urea cycle enzymes. I. Renal concentrating ability and urea cycle enzymes in the rat during protein deprivation. causal interaction,unassigned 1,0 3.5.3.1 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25392710&form=6&db=m Protein energy malnutrition increases arginase activity in monocytes and macrophages. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Marek Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11900957&form=6&db=m Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7173402&form=6&db=m The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640716&form=6&db=m Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20463604&form=6&db=m Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1. unassigned - 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21029397&form=6&db=m Recombinant Human Arginase Inhibits the In vitro and In vivo Proliferation of Human Melanoma by Inducing Cell Cycle Arrest and Apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737831&form=6&db=m An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27757311&form=6&db=m Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28464918&form=6&db=m Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. ongoing research,therapeutic application,unassigned 2,3,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29026308&form=6&db=m Role of poly(?-caprolactone) lipid-core nanocapsules on melanoma-neutrophil crosstalk. causal interaction,unassigned 2,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29660463&form=6&db=m Liposomal CpG-ODN: An in vitro and in vivo study on macrophage subtypes responses, biodistribution and subsequent therapeutic efficacy in mice models of cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29776373&form=6&db=m Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155941&form=6&db=m Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31597943&form=6&db=m Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy. unassigned - 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852848&form=6&db=m Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. unassigned - 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468644&form=6&db=m Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32843682&form=6&db=m Differential association of CD68+ and CD163+ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32890791&form=6&db=m Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach. therapeutic application,unassigned 1,0 3.5.3.1 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363180&form=6&db=m Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Melanosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28627081&form=6&db=m Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.5.3.1 Melioidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26311902&form=6&db=m The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease. causal interaction,diagnostic usage,unassigned 3,1,0 3.5.3.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27986516&form=6&db=m Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats. ongoing research,unassigned 1,0 3.5.3.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32628296&form=6&db=m Effect of diet supplemented with P. ostreatus and L. subnudus on memory index and key enzymes linked with Alzheimer's disease in streptozotocin-induced diabetes rats. unassigned - 3.5.3.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28464918&form=6&db=m Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. ongoing research,therapeutic application,unassigned 2,3,0 3.5.3.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30066894&form=6&db=m Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28464918&form=6&db=m Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. ongoing research,therapeutic application,unassigned 2,3,0 3.5.3.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5438971&form=6&db=m [Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies] unassigned - 3.5.3.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5438972&form=6&db=m [Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.] unassigned - 3.5.3.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32149110&form=6&db=m Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension. causal interaction,unassigned 3,0 3.5.3.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32769929&form=6&db=m A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19169141&form=6&db=m Transcriptional changes in blood after aerobic interval training in patients with the metabolic syndrome. causal interaction,unassigned 3,0 3.5.3.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441715&form=6&db=m Arginase inhibition alleviates hypertension in the metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232927&form=6&db=m Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28704931&form=6&db=m Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.5.3.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048462&form=6&db=m Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Metabolism, Inborn Errors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30199767&form=6&db=m In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases. diagnostic usage,unassigned 1,0 3.5.3.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33717053&form=6&db=m Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556586&form=6&db=m Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO. ongoing research,unassigned 4,0 3.5.3.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22507752&form=6&db=m Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24770974&form=6&db=m The importance of nitric oxide and arginase in the pathogenesis of acute neuroinflammation: are those contra players with the same direction? causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31280447&form=6&db=m Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis. ongoing research,unassigned 1,0 3.5.3.1 Multiple Sclerosis, Relapsing-Remitting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24770974&form=6&db=m The importance of nitric oxide and arginase in the pathogenesis of acute neuroinflammation: are those contra players with the same direction? causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7463093&form=6&db=m Metabolite alterations in the genetically spastic mouse. causal interaction,unassigned 3,0 3.5.3.1 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31484827&form=6&db=m Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11370664&form=6&db=m Expression, purification, and characterization of human type II arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11478904&form=6&db=m Classical and slow-binding inhibitors of human type II arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20505827&form=6&db=m Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863373&form=6&db=m [Arginase activity in plasma and erythrocytes in children with hematologic diseases] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.5.3.1 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29227812&form=6&db=m Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia. causal interaction,unassigned 2,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1139781&form=6&db=m Early diagnosis of myocardial infarction by arginase activity determination. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1250763&form=6&db=m [Usefulness of serum arginase activity determination in the diagnosis of acute myocardial infarct] causal interaction,diagnostic usage,unassigned 3,4,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5449817&form=6&db=m [Clinical value of arginase activity determination in human blood serum: diagnosis of myocardial infarction] diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5525184&form=6&db=m Occurrence of arginase in human blood serum in patients with myocardial infarction. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369504&form=6&db=m Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness. causal interaction,diagnostic usage,unassigned 4,3,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19726439&form=6&db=m Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. causal interaction,unassigned 1,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896478&form=6&db=m Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21704615&form=6&db=m Serum levels of arginase I are associated with left ventricular function after myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24183975&form=6&db=m Arginase as a target for treatment of myocardial ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34237174&form=6&db=m Arginase 1 is upregulated at admission in patients with ST-elevation myocardial infarction. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 3.5.3.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707069&form=6&db=m Coronary microvascular dysfunction in the setting of chronic ischemia is independent of arginase activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.5.3.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23472952&form=6&db=m Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury. therapeutic application,unassigned 4,0 3.5.3.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30248443&form=6&db=m Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.5.3.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26487482&form=6&db=m Comparison of arginase isoform expression in patients with different subtypes of chronic rhinosinusitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115381&form=6&db=m Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557431&form=6&db=m [Arginase as a marker of cancerogenesis. I. Monitoring patients after resection of colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557432&form=6&db=m [Arginase a marker of cancerogenesis. II. Monitoring of patients after resection of colorectal liver metastases] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12865923&form=6&db=m Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15074017&form=6&db=m [Arginase as a marker of cancerogenesis. III. Comparison of arginase activity with CEA and Ca 19-9 in liver metastases of colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15771127&form=6&db=m [Usefulness of postoperative assay of arginase activity in blood serum of women after breast cancer resection] diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16313824&form=6&db=m [Proteome study of colorectal cancer genesis and hepatic metastasis] diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16711512&form=6&db=m Arginase as a useful factor for the diagnosis of colorectal cancer liver metastases. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,3,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101531&form=6&db=m l-Arginine as a factor increasing arginase significance in diagnosis of primary and metastatic colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382585&form=6&db=m Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25739439&form=6&db=m Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-Mediated Inflammatory Cell Infiltration. causal interaction,unassigned 3,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483205&form=6&db=m TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases. causal interaction,unassigned 4,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050175&form=6&db=m Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept. causal interaction,unassigned 4,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28680747&form=6&db=m Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29854802&form=6&db=m The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514398&form=6&db=m Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17467&form=6&db=m Some new approaches to potential test systems for drugs against prostatic cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=163221&form=6&db=m Characterization of a Wilms' tumor model. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=187334&form=6&db=m The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=444403&form=6&db=m Microenvironmental arginine depletion by macrophages in vivo. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=462590&form=6&db=m [Effect of vitamin A in significant doses on incorporation of (14C) retinol, acceptor capacity of tRNA and activity of certain enzymes in tissues and plasma membranes of cells in the presence of Guerin's carcinoma] causal interaction,diagnostic usage,unassigned 1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=661984&form=6&db=m Activated macrophages kill tumour cells by releasing arginase. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=721109&form=6&db=m Properties of partially purified arginase from mouse lung tumour. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=724576&form=6&db=m [Role of arginine and arginase in tumors] causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=885601&form=6&db=m Effect of hydrocortisone on arginase activity in ICRC mouse mammary tumours in vitro. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1010566&form=6&db=m Occurrence of isoenzymes of arginase in mouse lung tumour. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1401910&form=6&db=m Macrophage arginine metabolism and the inhibition or stimulation of cancer. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1643605&form=6&db=m Clinical significance of arginase in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1802207&form=6&db=m Arginine metabolism in benign and malignant disease of breast and colon: evidence for possible inhibition of tumor-infiltrating macrophages. causal interaction,ongoing research,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1830780&form=6&db=m Expression of arginase by mouse myeloid leukemic cell differentiation in vitro induced with tumor necrosis factor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2148642&form=6&db=m Inhibitory effect of mycoplasma-released arginase. Activity in mixed-lymphocyte and tumour cell cultures. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2360989&form=6&db=m Properties of arginase immobilized in a fibrin clot. therapeutic application,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2601556&form=6&db=m Altered ornithine metabolism in tumor-bearing mice. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2696347&form=6&db=m Molecular genetics of ornithine decarboxylase in human tumor cells. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2895650&form=6&db=m Hypolipidemic drug clofibrate induces hepatic dedifferentiation. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3117587&form=6&db=m Purification, modification, physico-chemical and pharmacokinetic characterization of arginase, an enzyme of potential use in therapy. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3155494&form=6&db=m Enzyme activities in prostatic carcinoma related to Gleason grades. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3435681&form=6&db=m Effects of female sex steroids on concanavalin A-mediated agglutination of hepatocytes from nonregenerating and regenerating rat liver and hepatic tumor marker enzymes. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3449318&form=6&db=m The effects of arginase on neoplasm. I. The role of arginase in the immunosuppressive effects of extract from gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3698012&form=6&db=m Effector mechanisms of human monocyte-mediated tumor cytotoxicity in vitro: biochemical, functional, and serological characterization of cytotoxins produced by peripheral blood monocytes isolated by counterflow elutriation. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3811280&form=6&db=m [Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4027373&form=6&db=m [Changes in arginase activity during neurinoma growth] diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4090369&form=6&db=m [Brain arginase isoenzyme activity during the growth of neurinomas] diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4119243&form=6&db=m Arginase in human urogenital tumors. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4315357&form=6&db=m Arginase activity in nickel sulfide-induced rat tumors. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4421360&form=6&db=m The inhibition of arginase by proline in cell-free extracts of mouse mammary tumour. causal interaction,therapeutic application,unassigned 1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4448486&form=6&db=m Influence of hormonal status on arginase activity in mammary tissue and tumour. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6189588&form=6&db=m Arginase activity in prostatic tissue of patients with benign prostatic hyperplasia and prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6488153&form=6&db=m Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7428045&form=6&db=m Functional heterogeneity among peritoneal macrophages. III. No evidence for the role of arginase in the inhibition of tumor cell growth by supernatants from macrophages or macrophage subpopulation cultures. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636258&form=6&db=m Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8111729&form=6&db=m Inhibitory effect of arginine restriction on hepatoma growth. ongoing research,therapeutic application,unassigned 2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8124860&form=6&db=m Plasma arginase concentration measured by an enzyme-linked immunosorbent assay (ELISA) in normal adult population. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276724&form=6&db=m Chemical modification by polyethylene glycol of the anti-tumor enzyme arginine deiminase from Mycoplasma arginini. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8428392&form=6&db=m Differential mechanisms of intracellular killing of Mycobacterium avium and Listeria monocytogenes by activated human and murine macrophages. The role of nitric oxide. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797936&form=6&db=m Immunohistochemical study of arginase in cancer of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8877337&form=6&db=m Arginase activity determination. A marker of large bowel mucosa proliferation. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8947521&form=6&db=m Alteration in IL-1 and arginase activity of tumor-associated macrophages: a role in the promotion of tumor growth. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9037225&form=6&db=m Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9062893&form=6&db=m Tumour effect on arginine/ornithine metabolic relationship in hypertrophic mouse kidney. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9217082&form=6&db=m Neurotoxicity of soluble macrophage products in vitro--influence of dexamethasone. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9338115&form=6&db=m Differences of alkaline phosphatase and arginase activities in human colorectal carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756558&form=6&db=m NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408309&form=6&db=m Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10431034&form=6&db=m Arginine and nutrition in renal disease. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666305&form=6&db=m Induction of arginase II in human Caco-2 tumor cells by cyclic AMP. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10738908&form=6&db=m Arginase and ornithine, as markers in human non-small cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221839&form=6&db=m Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270424&form=6&db=m Possible implications of arginase and diamine oxidase in prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11329531&form=6&db=m Significance of arginase and ornithine in malignant tumors of the human skin. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11461922&form=6&db=m Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592308&form=6&db=m Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11900957&form=6&db=m Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12049190&form=6&db=m Diagnostic performance of arginase activity in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115381&form=6&db=m Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388114&form=6&db=m Immunocompetence of macrophages in rats exposed to Candida albicans infection and stress. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530480&form=6&db=m Arginase activity is inhibited by L-NAME, both in vitro and in vivo. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557431&form=6&db=m [Arginase as a marker of cancerogenesis. I. Monitoring patients after resection of colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12557432&form=6&db=m [Arginase a marker of cancerogenesis. II. Monitoring of patients after resection of colorectal liver metastases] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559605&form=6&db=m Arginase in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12701828&form=6&db=m Arginine deprivation and tumour cell death: arginase and its inhibition. ongoing research,therapeutic application,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12865923&form=6&db=m Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928840&form=6&db=m Elevated serum arginase activity levels in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13082430&form=6&db=m TREATMENT of cancer with arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13094683&form=6&db=m Lack of effect of high potency arginase on tumor growth. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13128046&form=6&db=m [Effect of polysaccharides from cancer urine and tissues on liver catalase and arginase.] ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13489960&form=6&db=m [Blood arginase in cancer patients.] diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13663042&form=6&db=m The histological distribution of arginase activity in solid mouse tumor transplants and a comparison with ascites tumors and normal tissues. diagnostic usage,ongoing research,unassigned 2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13746236&form=6&db=m Alterations in morphology, arginase, and beta-glucuronidase within a clone of mouse tumor cells in vitro. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14098784&form=6&db=m [EXPLORATION OF ARGINASE ACTIVITY IN THE COURSE OF LIVER DISEASES, TUMORS AND INCLUSIVE.] unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14316215&form=6&db=m THE EFFECT OF ARGINASE ON THE RETARDATION OF TUMOUR GROWTH. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14572312&form=6&db=m rIFN-gamma-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719140&form=6&db=m Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15074017&form=6&db=m [Arginase as a marker of cancerogenesis. III. Comparison of arginase activity with CEA and Ca 19-9 in liver metastases of colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15276021&form=6&db=m Arginase pathway in human endothelial cells in pathophysiological conditions. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313928&form=6&db=m Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15435984&form=6&db=m [Enzymes in benign and malignant tumors of the liver; arginase and histidase.] ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494015&form=6&db=m The role of SHIP1 in macrophage programming and activation. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15824085&form=6&db=m Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833831&form=6&db=m Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911102&form=6&db=m Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186186&form=6&db=m Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16313824&form=6&db=m [Proteome study of colorectal cancer genesis and hepatic metastasis] diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357187&form=6&db=m Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709924&form=6&db=m Suppression of T-cell functions by human granulocyte arginase. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17023580&form=6&db=m L-arginine availability regulates T-lymphocyte cell-cycle progression. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17046281&form=6&db=m Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses caused by the ectoparasite Ichthyophthirius multifiliis. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101732&form=6&db=m Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17255300&form=6&db=m Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17276463&form=6&db=m Role of non-neuronal cholinergic system in breast cancer progression. causal interaction,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17398016&form=6&db=m Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405289&form=6&db=m [Arginase activity in blood serum of patients with acute and chronic pancreatitis] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413034&form=6&db=m TNF-alpha contributes to endothelial dysfunction by upregulating arginase in ischemia/reperfusion injury. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513447&form=6&db=m Arginine and immunity. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640716&form=6&db=m Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17689108&form=6&db=m Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17966882&form=6&db=m [Serum arginase activity in patients with liver cirrhosis and hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18078830&form=6&db=m Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18364002&form=6&db=m Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18394650&form=6&db=m The significance of arginase I administration on the survival of mice bearing NS-1 myeloma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18472017&form=6&db=m Constitutive intracellular production of iNOS and NO in human melanoma: possible role in regulation of growth and resistance to apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18486631&form=6&db=m Nitric oxide, apoptosis and macrophage polarization during tumor progression. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528866&form=6&db=m Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559619&form=6&db=m Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18663728&form=6&db=m Disruption of arginase II alters prostate tumor formation in TRAMP mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817562&form=6&db=m Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18828017&form=6&db=m Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138817&form=6&db=m Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282757&form=6&db=m Arginase activity in carcinoma of the gallbladder: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362167&form=6&db=m Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19374748&form=6&db=m Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC). diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19402383&form=6&db=m Expression of immunomodulating genes in prostate cancer and benign prostatic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19414774&form=6&db=m Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449184&form=6&db=m Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice. diagnostic usage,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19494083&form=6&db=m Differential activation of peritoneal cells by subcutaneous treatment of rats with cryptococcal antigens. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19608981&form=6&db=m Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19689743&form=6&db=m Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19738057&form=6&db=m In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19997976&form=6&db=m The Redox State of the Glutathione/Glutathione Disulfide Couple Mediates Intracellular Arginase Activation in HCT-116 Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20028977&form=6&db=m Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20050660&form=6&db=m Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200236&form=6&db=m Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200399&form=6&db=m Human eosinophil granulocytes do not express the enzyme arginase. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382585&form=6&db=m Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20463604&form=6&db=m Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20466402&form=6&db=m Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20542107&form=6&db=m Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20644162&form=6&db=m Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20661013&form=6&db=m Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20701773&form=6&db=m Effects of mitochondrial dysfunction on the immunological properties of microglia. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717004&form=6&db=m Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20856806&form=6&db=m Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861464&form=6&db=m HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876310&form=6&db=m HIF-1? regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951704&form=6&db=m Ex vivo simulation of leukocyte function: Stimulation of specific subset of leukocytes in whole blood followed by the measurement of function-associated mRNAs. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115102&form=6&db=m Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup. diagnostic usage,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21240484&form=6&db=m Suppression of T-cell responses by tumor metabolites. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21255410&form=6&db=m The immunoregulatory mechanisms of carcinoma for its survival and development. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21633700&form=6&db=m T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21647872&form=6&db=m Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21810604&form=6&db=m Regulation of macrophage arginase expression and tumor growth by the ron receptor tyrosine kinase. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843082&form=6&db=m Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870783&form=6&db=m Crystal Structures of Complexes with Cobalt-Reconstituted Human Arginase I. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21918827&form=6&db=m Oxidant-mediated modification of the cellular thiols is sufficient for arginase activation in cultured cells. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21918895&form=6&db=m Dual biological effects of the cytokines interleukin-10 and interferon-?. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001609&form=6&db=m Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22018099&form=6&db=m Critical illness induces alternative activation of M2 macrophages in adipose tissue. diagnostic usage,ongoing research,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22145026&form=6&db=m Activation of PPAR? in myeloid cells promotes lung cancer progression and metastasis. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287720&form=6&db=m Decoy Receptor 3 Enhances Tumor Progression via Induction of Tumor-Associated Macrophages. causal interaction,ongoing research,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22348173&form=6&db=m Recombinant human arginase toxicity in mice is reduced by citrulline supplementation. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442118&form=6&db=m Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546217&form=6&db=m Deprivation of arginine by recombinant human arginase in prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578109&form=6&db=m Targeting macrophages in the tumour environment to enhance the efficacy of ?OX40 therapy. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22737599&form=6&db=m SCHEMA Designed Variants of Human Arginase I & II Reveal Sequence Elements Important to Stability and Catalysis. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22806093&form=6&db=m Distinct in vivo CD8 and CD4 T cell responses against normal and malignant tissues. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848265&form=6&db=m Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22873218&form=6&db=m Anti-tumor Efficacy of a Recombinant Human Arginase in Human Hepatocellular Carcinoma. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22904131&form=6&db=m Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22914051&form=6&db=m Opposing roles for complement component c5a in tumor progression and the tumor microenvironment. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22926062&form=6&db=m Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22991499&form=6&db=m Interferon-gamma-induced nitric oxide inhibits the proliferation of murine renal cell carcinoma cells. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23017138&form=6&db=m Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives. therapeutic application,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23038227&form=6&db=m Arginase activity in patients with breast cancer: an analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23222714&form=6&db=m Role of OGR1 in myeloid-derived cells in prostate cancer. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23232789&form=6&db=m Eplerenone reduced lesion size in early but not advanced atherosclerosis in apolipoprotein E-deficient mice. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23243594&form=6&db=m Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23327293&form=6&db=m Impact of substrate protonation and tautomerization States on interactions with the active site of arginase I. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359393&form=6&db=m Effect of occupational exposure to aflatoxins on some liver tumor markers in textile workers. diagnostic usage,therapeutic application,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23365669&form=6&db=m Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625224&form=6&db=m Expression, purification, and biochemical properties of arginase from Bacillus subtilis 168. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737831&form=6&db=m An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763571&form=6&db=m Increased levels of circulating arginase I in overweight compared to normal weight adolescents. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23917632&form=6&db=m Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23983191&form=6&db=m Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared to their peripheral counterparts. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24113174&form=6&db=m Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin's lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24135499&form=6&db=m Axitinib, a selective inhibitor of vascular endothelial growth factor receptor, exerts an anticancer effect in melanoma through promoting antitumor immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24225578&form=6&db=m Newly available antibodies with practical applications in surgical pathology. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,3 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24246920&form=6&db=m [Role of arginase-1 expression in distinguishing hepatocellular carcinoma from non-hepatocellular tumors]. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354980&form=6&db=m Small-molecule arginase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24421272&form=6&db=m Galectin-3 disruption impaired tumoral angiogenesis by reducing VEGF secretion from TGF?1-induced macrophages. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446520&form=6&db=m TNF-?-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24500984&form=6&db=m Mouse bone marrow-derived mesenchymal stem cells induce macrophage M2 polarization through the nuclear factor-?B and signal transducer and activator of transcription 3 pathways. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24553452&form=6&db=m Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24614600&form=6&db=m Possible role of arginase-1 in concomitant tumor immunity. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24616165&form=6&db=m Exposure of polyethylene particles induces interferon-? expression in a natural killer T lymphocyte and dendritic cell coculture system in vitro: A preliminary study. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24651438&form=6&db=m ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24657159&form=6&db=m Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a d-galactose-induced accelerated aging mouse model. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24658839&form=6&db=m Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24662052&form=6&db=m Pten null prostate epithelium promotes localized MDSC expansion and immune suppression during tumor initiation and progression. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24881877&form=6&db=m Resolution mediator chemerin15 reprograms the wound microenvironment to promote repair and reduce scarring. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24911253&form=6&db=m Arginase-1 is a novel immunohistochemical marker of hepatocellular differentiation. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992164&form=6&db=m Expression of arginase I in myeloid cells limits control of residual disease after radiation therapy of tumors in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24995657&form=6&db=m Mesenchymal stem cells induce the ramification of microglia via the small RhoGTPases Cdc42 and Rac1. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25027824&form=6&db=m Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25043024&form=6&db=m Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25046175&form=6&db=m Characterization of vascular complications in experimental model of fructose-induced metabolic syndrome. diagnostic usage,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25104794&form=6&db=m Granulocyte functions are independent of arginine availability. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25135690&form=6&db=m Arginine Supplementation Induces Arginase Activity and Inhibits TNF-? Synthesis in Mice Spleen Macrophages After Intestinal Obstruction. ongoing research,therapeutic application,unassigned 4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25153903&form=6&db=m Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury. therapeutic application,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25275027&form=6&db=m Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310970&form=6&db=m uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25322968&form=6&db=m Purification and immobilization of L-arginase from thermotolerant Penicillium chrysogenum KJ185377.1; with unique kinetic properties as thermostable anticancer enzyme. therapeutic application,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25353287&form=6&db=m Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25370534&form=6&db=m Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models. causal interaction,ongoing research,unassigned 2,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25394503&form=6&db=m Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25406192&form=6&db=m l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells. causal interaction,therapeutic application,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25425006&form=6&db=m Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells. ongoing research,therapeutic application,unassigned 2,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25437558&form=6&db=m Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25473368&form=6&db=m The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25474015&form=6&db=m Arginine deprivation in cancer therapy. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501824&form=6&db=m Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25612247&form=6&db=m The effects of WW2/WW3 domains of Smurf2 molecule on TGF-? signaling and arginase I gene expression. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25707593&form=6&db=m Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an m1 phenotype in retinal microglia. diagnostic usage,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25739439&form=6&db=m Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-Mediated Inflammatory Cell Infiltration. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25759778&form=6&db=m Effect of rosuvastatin on arginase enzyme activity and polyamine production in experimental breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25802006&form=6&db=m Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904129&form=6&db=m The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25917076&form=6&db=m Targeting arginine metabolism pathway to treat arginine-dependent cancers. causal interaction,therapeutic application,unassigned 1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25922428&form=6&db=m Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25961933&form=6&db=m Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment. causal interaction,ongoing research,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963565&form=6&db=m The Promise of Plant-Derived Substances as Inhibitors of Arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26035689&form=6&db=m Ovarian cancer stem cells induce the M2 polarization of macrophages through the PPAR? and NF-?B pathways. diagnostic usage,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26054597&form=6&db=m Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26081514&form=6&db=m [Effects of metformin on the polarization and Notch 1 expression of RAW264.7 macrophages]. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26148932&form=6&db=m Temporal profile of M1 and M2 responses in the hippocampus following early 24h of neurotrauma. diagnostic usage,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26230595&form=6&db=m Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26277096&form=6&db=m Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK. therapeutic application,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26278104&form=6&db=m An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26294209&form=6&db=m CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26300935&form=6&db=m Diagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26325075&form=6&db=m Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26388569&form=6&db=m Effects of Nanosized Lithium Carbonate Particles on the Functional Activity of Macrophages During Development of Hepatocarcinoma 29. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26429502&form=6&db=m NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26473343&form=6&db=m The Applicability of a Human Immunohistochemical Panel to Mouse Models of Hepatocellular Neoplasia. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592964&form=6&db=m Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26625316&form=6&db=m Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26638110&form=6&db=m Clear cell hepatocellular carcinoma diagnosed by bile duct brushing cytology. diagnostic usage,ongoing research,unassigned 2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26643895&form=6&db=m Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26754935&form=6&db=m Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26818550&form=6&db=m Circulating myeloid-derived suppressor cells in patients with pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26852599&form=6&db=m [Effects of lithium carbonate nanosized particles on nitric oxide production and arginase activity in tumor and peritoneal macrophages in hepatocellular carcinoma 29]. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884647&form=6&db=m Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to ? Amyloid via Protein Kinase C. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26913960&form=6&db=m Molecular basis and current strategies of therapeutic arginine depletion for cancer. ongoing research,therapeutic application,unassigned 2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927552&form=6&db=m [Adipose-derived stem cells promote the polarization from M1 macrophages to M2 macrophages]. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26939998&form=6&db=m The effect of chemically modified alginates on macrophage phenotype and biomolecule transport. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26978353&form=6&db=m Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27006175&form=6&db=m Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27031640&form=6&db=m Correction: Possible Role of Arginase-1 in Concomitant Tumor Immunity. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27039210&form=6&db=m Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050175&form=6&db=m Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27066094&form=6&db=m Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27141394&form=6&db=m Immunosuppressive parameters in serum of ovarian cancer patients change during the disease course. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27149420&form=6&db=m Atorvastatin attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats postmyocardial infarction. diagnostic usage,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27180260&form=6&db=m Intracellular sources of ornithine for polyamine synthesis in endothelial cells. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27213058&form=6&db=m Gypenoside Attenuates ? Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling. causal interaction,diagnostic usage,unassigned 1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27249753&form=6&db=m Immunotherapy: Beyond Anti-PD-1 and Anti-PD-L1 Therapies. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27261626&form=6&db=m Silymarin suppressed lung cancer growth in mice via inhibiting myeloid-derived suppressor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27363017&form=6&db=m Human cytomegalovirus may promote tumour progression by upregulating arginase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27378625&form=6&db=m Oxidative stress, polarization of macrophages and tumour angiogenesis: Efficacy of caffeic acid. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27405164&form=6&db=m [Correlation between autophagy and polarization of macrophages in atherosclerosis plaque in arteriosclerosis obliterans amputees]. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27474951&form=6&db=m Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27497194&form=6&db=m Inhibition of curcumin on myeloid-derived suppressor cells is requisite for controlling lung cancer. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27558349&form=6&db=m A nanobiosensor for the detection of arginase activity. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27563494&form=6&db=m Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response. diagnostic usage,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622331&form=6&db=m T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27634753&form=6&db=m Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27653627&form=6&db=m EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer. ongoing research,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27734327&form=6&db=m Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27811065&form=6&db=m Cellular and Molecular Pathways Leading to External Root Resorption. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27819142&form=6&db=m IL-4R? aptamer-liposome-CpG oligodeoxynucleotides suppress tumour growth by targeting the tumour microenvironment. diagnostic usage,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008146&form=6&db=m Autologous reconstitution of human cancer and immune system in vivo. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28109144&form=6&db=m [Interferon regulatory factor 5 (IRF5) regulates the differentiation of bone marrow-derived macrophages in mice]. diagnostic usage,ongoing research,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28257800&form=6&db=m Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28358368&form=6&db=m A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor. therapeutic application,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28411578&form=6&db=m Differential effects of low-dose fludarabine or 5-fluorouracil on the tumor growth and myeloid derived immunosuppression status of tumor-bearing mice. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28458629&form=6&db=m Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. diagnostic usage,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28494546&form=6&db=m [Regulatory effect of bone marrow mesenchymal stem cells on polarization of macrophages]. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28615091&form=6&db=m [Detection and analysis of phenotypes of tumor-associated macrophages in mouse model of spontaneous breast cancer]. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28629014&form=6&db=m Physicochemical properties of liposomal modifiers that shift macrophage phenotype. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28630636&form=6&db=m Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage-Mediated Lung Cancer in Mice. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28675010&form=6&db=m [Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation]. diagnostic usage,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28680747&form=6&db=m Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28682138&form=6&db=m Denatonium and Naringenin Promote SCA-9 Tumor Growth and Angiogenesis: Participation of Arginase. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28690100&form=6&db=m Arginase purified from endophytic Pseudomonas aeruginosa IH2: Induce apoptosis through both cell cycle arrest and MMP loss in human leukemic HL-60 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714032&form=6&db=m ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin?C via Wnt/??catenin pathway. causal interaction,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28718378&form=6&db=m MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28785178&form=6&db=m Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,2 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28794630&form=6&db=m Probiotics protect mice from CoCrMo particles-induced osteolysis. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808255&form=6&db=m Critical role for arginase 2 in obesity-associated pancreatic cancer. causal interaction,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28813782&form=6&db=m Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28814568&form=6&db=m Fetal-type gastrointestinal adenocarcinoma: a morphologically distinct entity with unfavourable prognosis. diagnostic usage,therapeutic application,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28830617&form=6&db=m Cancer-promoting mechanisms of tumor-associated neutrophils. causal interaction,ongoing research,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28835451&form=6&db=m Obesity-induced vascular inflammation involves elevated arginase activity. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28892747&form=6&db=m Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro. causal interaction,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28904063&form=6&db=m Anti-Jagged immunotherapy inhibits MDSCs and overcomes tumor-induced tolerance. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28939160&form=6&db=m Hepatocellular carcinoma with neuroendocrine differentiation: a case report. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28970136&form=6&db=m A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29028606&form=6&db=m Inflammatory and biocompatibility evaluation of antimicrobial peptide GL13K immobilized onto titanium by silanization. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29051526&form=6&db=m Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222914&form=6&db=m Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254508&form=6&db=m Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29259373&form=6&db=m Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages. diagnostic usage,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363180&form=6&db=m Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29391126&form=6&db=m Research of novel anticancer agents targeting arginase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399404&form=6&db=m Frequent adaptive immune responses against arginase-1. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29410946&form=6&db=m Tumor-Associated Macrophages: Therapeutic Targets for Skin Cancer. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29412048&form=6&db=m Arginase: A Multifaceted Enzyme Important in Health and Disease. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29488625&form=6&db=m Arginase-1 is neither constitutively expressed in nor required for myeloid-derived suppressor cell-mediated inhibition of T-cell proliferation. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29620585&form=6&db=m Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29660336&form=6&db=m MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-associated macrophage FGF2 expression. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29668503&form=6&db=m Tetrahydroxystilbene glycoside antagonizes ?-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression. causal interaction,diagnostic usage,unassigned 1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685921&form=6&db=m Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29854802&form=6&db=m The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883780&form=6&db=m Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29892522&form=6&db=m Blockade of CCL2 enhances immunotherapeutic effect of anti-PD1 in lung cancer. therapeutic application,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29914893&form=6&db=m Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928279&form=6&db=m Myeloid-Derived Suppressor Cells Specifically Suppress IFN-? Production and Antitumor Cytotoxic Activity of V?2 T Cells. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961402&form=6&db=m Primary Hepatoid Carcinoma of the Pancreas: A Clinicopathological Study of 3 Cases With Review of Additional 31 Cases in the Literature. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29992073&form=6&db=m Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016877&form=6&db=m Continuous Inhalation Exposure to Fungal Allergen Particulates Induces Lung Inflammation While Reducing Innate Immune Molecule Expression in the Brainstem. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30151521&form=6&db=m 6-Gingerol as an arginase inhibitor prevents urethane-induced lung carcinogenesis by reprogramming tumor supporting M2 macrophages to M1 phenotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155941&form=6&db=m Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30228936&form=6&db=m Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30315387&form=6&db=m PGC-1?-Mediated Mitochondrial Biogenesis is Involved in Cannabinoid Receptor 2 Agonist AM1241-Induced Microglial Phenotype Amelioration. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30366378&form=6&db=m Tart Cherry Reduces Inflammation in Adipose Tissue of Zucker Fatty Rats and Cultured 3T3-L1 Adipocytes. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30520685&form=6&db=m Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30528455&form=6&db=m Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production. causal interaction,therapeutic application,unassigned 1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540970&form=6&db=m 1,25?Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30545920&form=6&db=m Macrophage-Derived IL1? and TNF? Regulate Arginine Metabolism in Neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572269&form=6&db=m A high-corn-oil diet strongly stimulates mammary carcinogenesis, while a high-extra-virgin-olive-oil diet has a weak effect, through changes in metabolism, immune system function and proliferation/apoptosis pathways. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578463&form=6&db=m Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30589787&form=6&db=m Promotion of Primary Murine Breast Cancer Growth and Metastasis by Adipose-Derived Stem Cells Is Reduced in the Presence of Autologous Fat Graft. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30605863&form=6&db=m Metabolic pathways of L-arginine and therapeutic consequences in tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30613266&form=6&db=m Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages. causal interaction,therapeutic application,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30627268&form=6&db=m Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature. diagnostic usage,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30661440&form=6&db=m Vitamin D improves sunburns by increasing autophagy in M2 macrophages. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683148&form=6&db=m High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30695592&form=6&db=m [Study of arginase activity of mixed saliva in cancer]. causal interaction,diagnostic usage,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30728077&form=6&db=m Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30778288&form=6&db=m Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30808864&form=6&db=m Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30886438&form=6&db=m Engineered immune cells as highly sensitive cancer diagnostics. diagnostic usage,ongoing research,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30919084&form=6&db=m A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137). ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30974698&form=6&db=m Investigating the Synergistic Effects of Combined Modified Alginates on Macrophage Phenotype. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30993582&form=6&db=m Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31008530&form=6&db=m CARD9 prevents lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31019617&form=6&db=m Prognostic Implications of Arginase and Cytokeratin 19 Expression in Hepatocellular Carcinoma After Curative Hepatectomy: Correlation With Recurrence-Free Survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31051694&form=6&db=m Arginase-1 and HepPar-1 expression in fine-needle aspiration specimens of primary lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31053913&form=6&db=m Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31084559&form=6&db=m Analysis of Macrophage Activation Markers in an Experimental Model of Cutaneous Leishmaniasis Treated with Photodynamic Therapy Mediated by 5-Aminolevulinic Acid. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31261028&form=6&db=m Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278254&form=6&db=m Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31323530&form=6&db=m Wnt-3a alleviates neuroinflammation after ischemic stroke by modulating the responses of microglia/macrophages and astrocytes. causal interaction,diagnostic usage,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31338874&form=6&db=m Bone marrow macrophage M2 polarization and adipose-derived stem cells osteogenic differentiation synergistically promote rehabilitation of bone damage. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31387898&form=6&db=m Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer. causal interaction,therapeutic application,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31488173&form=6&db=m Liver metastatic basaloid squamous cell carcinoma with negative expression of pancytokeratin: a case report and literature review. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552680&form=6&db=m Key genes and pathways in tumor-educated dendritic cells by bioinformatical analysis. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31597943&form=6&db=m Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614930&form=6&db=m Hepatic Stellate Cells Enhance Liver Cancer Progression by Inducing Myeloid-Derived Suppressor Cells through Interleukin-6 Signaling. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31620648&form=6&db=m Well differentiated arginase-1 negative hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31629728&form=6&db=m The potential therapeutic effect of NG-hydroxy-nor-L-arginine in 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31646104&form=6&db=m Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676785&form=6&db=m DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31690955&form=6&db=m Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31704881&form=6&db=m Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734894&form=6&db=m Impacts of replacement of dietary fish oil by vegetable oils on growth performance, anti-oxidative capacity, and inflammatory response in large yellow croaker Larimichthys crocea. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31751318&form=6&db=m Mitochondrial arginase-2 is a cell?autonomous regulator of CD8+ T cell function and antitumor efficacy. therapeutic application,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31770520&form=6&db=m Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31792727&form=6&db=m Correlation of PPM1A Downregulation with CYP3A4 Repression in the Tumor Liver Tissue of Hepatocellular Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31832003&form=6&db=m Toxoplasma ROP16I/III ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31861801&form=6&db=m Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31866829&form=6&db=m Electroacupuncture Pretreatment Alleviates Cerebral Ischemic Injury Through ?7 Nicotinic Acetylcholine Receptor-Mediated Phenotypic Conversion of Microglia. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31868337&form=6&db=m Macrophages - a perspective target for antineoplastic immunotherapy. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32029006&form=6&db=m Arginase promotes immune evasion of Echinococcus granulosus in mice. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033338&form=6&db=m Physalis angulata Calyces Modulate Macrophage Polarization and Alleviate Chemically Induced Intestinal Inflammation in Mice. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32052258&form=6&db=m Integrin CD11b Deficiency Aggravates Retinal Microglial Activation and RGCs Degeneration After Acute Optic Nerve Injury. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075359&form=6&db=m [Immune function of myeloid-derived suppressor cells and its mechanism in obstructive sleep apnea syndrome]. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32108248&form=6&db=m Age-associated differences in macrophage response in a vaginal wound healing rat model. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32118719&form=6&db=m The significance of arginase-1 expression in the diagnosis of liver cancer: A protocol for a systematic review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122662&form=6&db=m Macrophage Depletion Improves Chronic Rejection in Rats With Allograft Heart Transplantation. diagnostic usage,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144472&form=6&db=m A bioengineered arginine-depleting enzyme as a long-lasting therapeutic agent against cancer. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32174086&form=6&db=m [Effect of decellularized adipose tissue combined with vacuum sealing drainage on wound inflammation in pigs]. diagnostic usage,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32185135&form=6&db=m Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer. causal interaction,ongoing research,unassigned 1,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32217759&form=6&db=m Lactoferrin-containing immunocomplex mediates antitumor effects by resetting tumor-associated macrophages to M1 phenotype. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32233066&form=6&db=m Thin-layer chromatography-bioautographic method for the detection of arginase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32246211&form=6&db=m Characterization of macrophage phenotype, redox, and purinergic response upon chronic treatment with methionine and methionine sulfoxide in mice. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32292567&form=6&db=m Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32313729&form=6&db=m The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32332536&form=6&db=m Docosahexaenoic Acid Improves Diabetic Wound Healing in a Rat Model by Restoring Impaired Plasticity of Macrophage Progenitor Cells. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32402274&form=6&db=m Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418491&form=6&db=m High-Throughput Fluorescence-Based Activity Assay for Arginase-1. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468644&form=6&db=m Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32471888&form=6&db=m In situ hybridisation for albumin RNA in paediatric liver cancers compared with common immunohistochemical markers. diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32476791&form=6&db=m Ectopic hepatocellular carcinoma mimicking a retroperitoneal tumor: A case report. diagnostic usage,therapeutic application,unassigned 4,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485857&form=6&db=m ?-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32492189&form=6&db=m Cladribine modifies functional properties of microglia. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32499785&form=6&db=m Myeloid Cell-Derived Arginase in Cancer Immune Response. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32614387&form=6&db=m Increased Arginase1 expression in tumor microenvironment promotes mammary carcinogenesis via multiple mechanisms. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630667&form=6&db=m Cancer Immune Therapy for Philadelphia Chromosome-Negative Chronic Myeloproliferative Neoplasms. causal interaction,therapeutic application,unassigned 2,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32647818&form=6&db=m Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158. causal interaction,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32664318&form=6&db=m Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32692841&form=6&db=m Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32744000&form=6&db=m [Effects of butylphthalide on microglia activation in frontal lobe of rats after chronic sleep deprivation]. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32779289&form=6&db=m Lactobacillus rhamnosus GG promotes M1 polarization in murine bone marrow-derived macrophages by activating TLR2/MyD88/MAPK signaling pathway. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32783915&form=6&db=m Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802913&form=6&db=m Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32828425&form=6&db=m Boronic acid-based arginase inhibitors in cancer immunotherapy. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32843682&form=6&db=m Differential association of CD68+ and CD163+ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32923127&form=6&db=m The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967767&form=6&db=m [Progress in functions and mechanisms of immunosuppressive neutrophil subsets: An update]. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991342&form=6&db=m Hepatoid Teratoma, Hepatoid Yolk Sac Tumor, and Hepatocellular Carcinoma: A Morphologic and Immunohistochemical Study of 30 Cases. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050217&form=6&db=m Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33122966&form=6&db=m Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33129876&form=6&db=m Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment. therapeutic application,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33163819&form=6&db=m Impact of Marine-Based Biomaterials on the Immunoregulatory Properties of Bone Marrow-Derived Mesenchymal Stem Cells: Potential Use of Fish Collagen in Bone Tissue Engineering. diagnostic usage,ongoing research,unassigned 2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330446&form=6&db=m The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33335657&form=6&db=m Novel Arginase Inhibitors for Treating Cancer and Respiratory Inflammatory Diseases. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33348809&form=6&db=m Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33395072&form=6&db=m Arginine metabolism: a potential target in pancreatic cancer therapy. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33429504&form=6&db=m Identifying Factors of Microparticles Modified with Arginine Derivatives That Induce Phenotypic Shifts in Macrophages. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33464074&form=6&db=m Effects of Environmental pH on Macrophage Polarization and Osteoimmunomodulation. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479657&form=6&db=m Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors. therapeutic application,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33500272&form=6&db=m Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth. therapeutic application,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33503439&form=6&db=m Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells. ongoing research,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33510635&form=6&db=m Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524560&form=6&db=m An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33555306&form=6&db=m Ileocolonic Healing After Extended Small Bowel Resection in Mice: NOD2 Deficiency Impairs Anastomotic Healing and Postoperative Outcome. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33678599&form=6&db=m Soluble factors differ in platelets derived from separate niches: a pilot study comparing the secretome of peripheral blood and bone marrow platelets. diagnostic usage,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33714729&form=6&db=m Human splenic myeloid derived suppressor cells: Phenotypic and clustering analysis. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33717053&form=6&db=m Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33731531&form=6&db=m Differences Between Patients with and without Atherosclerosis in Expression Levels of Inflammatory Mediators in the Adipose Tissue Around the Coronary Artery. diagnostic usage,ongoing research,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754845&form=6&db=m Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33788466&form=6&db=m [Effect of acupoint thread-embedding on macrophage polarization of epididymis adipose tissue in obese mice]. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791071&form=6&db=m Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33807310&form=6&db=m ARG1 mRNA Level Is a Promising Prognostic Marker in Head and Neck Squamous Cell Carcinomas. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33816453&form=6&db=m Preconditioning Human Adipose-Derived Stromal Cells on Decellularized Adipose Tissue Scaffolds Within a Perfusion Bioreactor Modulates Cell Phenotype and Promotes a Pro-regenerative Host Response. causal interaction,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33863874&form=6&db=m Azithromycin alleviates systemic lupus erythematosus via the promotion of M2 polarisation in lupus mice. causal interaction,unassigned 1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33872730&form=6&db=m Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33890824&form=6&db=m A Study of Arginase Expression in Chronic Non-healing Wounds. causal interaction,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33948392&form=6&db=m Identification and characterization of B220+/B220- subpopulations in murine Gr1+CD11b+ cells during tumorigenesis. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33979616&form=6&db=m Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation. ongoing research,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025136&form=6&db=m Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031449&form=6&db=m Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34039237&form=6&db=m Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34059076&form=6&db=m Luteolin transforms the polarity of bone marrow-derived macrophages to regulate the cytokine storm. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34074677&form=6&db=m ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131176&form=6&db=m Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,3 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136541&form=6&db=m Inhibition of KCa3.1 Channels Suppresses Atrial Fibrillation via the Attenuation of Macrophage Pro-inflammatory Polarization in a Canine Model With Prolonged Rapid Atrial Pacing. diagnostic usage,unassigned 3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34146674&form=6&db=m Arginase plays an important role in ammonia detoxification of yellow catfish Pelteobagrus fulvidraco. diagnostic usage,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149591&form=6&db=m Effect of Hyperbaric Oxygen Therapy on Polarization Phenotype of Rat Microglia After Traumatic Brain Injury. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178876&form=6&db=m Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214728&form=6&db=m VitA or VitD ameliorates bronchopulmonary dysplasia by regulating the balance between M1 and M2 macrophages. diagnostic usage,unassigned 4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216004&form=6&db=m A case of primary carcinosarcoma of the liver with combined hepatocellular carcinoma and cholangiocarcinoma. ongoing research,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34254284&form=6&db=m Efficacy of expressions of Arg-1, Hep Par-1, and CK19 in the diagnosis of the primary hepatocellular carcinoma subtypes and exclusion of the metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34287772&form=6&db=m Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34301764&form=6&db=m Neuroblastoma formation requires unconventional CD4 T cells and Arginase-1-dependent myeloid cells. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309734&form=6&db=m Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment. therapeutic application,unassigned 2,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34344457&form=6&db=m The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367736&form=6&db=m Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393062&form=6&db=m Arginase Pathway Markers of Immune-Microenvironment in Thymic Epithelial Tumors and Small Cell Lung Cancer. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34451169&form=6&db=m Silicone Implants Immobilized with Interleukin-4 Promote the M2 Polarization of Macrophages and Inhibit the Formation of Fibrous Capsules. unassigned - 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527178&form=6&db=m Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528569&form=6&db=m Immunosuppressive effects and mechanisms of three myeloid-derived suppressor cells subsets including monocytic-myeloid-derived suppressor cells, granulocytic-myeloid-derived suppressor cells, and immature-myeloid-derived suppressor cells. diagnostic usage,unassigned 2,0 3.5.3.1 Neoplasms, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11329531&form=6&db=m Significance of arginase and ornithine in malignant tumors of the human skin. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Neoplasms, Nerve Tissue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3811280&form=6&db=m [Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.5.3.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11329531&form=6&db=m Significance of arginase and ornithine in malignant tumors of the human skin. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8691729&form=6&db=m L-arginine depletion inhibits glomerular nitric oxide synthesis and exacerbates rat nephrotoxic nephritis. causal interaction,unassigned 1,0 3.5.3.1 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3811280&form=6&db=m [Comparative study of the activity of arginase isoenzymes in brain tumors of humans and experimental animals] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.5.3.1 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4027373&form=6&db=m [Changes in arginase activity during neurinoma growth] diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4090369&form=6&db=m [Brain arginase isoenzyme activity during the growth of neurinomas] diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25961062&form=6&db=m IL-10 and ARG-1 concentrations in bone marrow and peripheral blood of metastatic neuroblastoma patients do not associate with clinical outcome. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26054597&form=6&db=m Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.5.3.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27057459&form=6&db=m Neuroblastoma arginine addiction subverts the anticancer immune response. therapeutic application,unassigned 1,0 3.5.3.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30545920&form=6&db=m Macrophage-Derived IL1? and TNF? Regulate Arginine Metabolism in Neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.5.3.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32722521&form=6&db=m Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective. therapeutic application,unassigned 1,0 3.5.3.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22483960&form=6&db=m Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. causal interaction,ongoing research,unassigned 3,4,0 3.5.3.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24770974&form=6&db=m The importance of nitric oxide and arginase in the pathogenesis of acute neuroinflammation: are those contra players with the same direction? causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26538310&form=6&db=m Arginase 1+ microglia reduce A? plaque deposition during IL-1?-dependent neuroinflammation. therapeutic application,unassigned 1,0 3.5.3.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27406711&form=6&db=m Modifying effect of intravenous laser therapy on the protein expression of arginase and epidermal growth factor receptor in type 2 diabetic patients. causal interaction,unassigned 4,0 3.5.3.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31979015&form=6&db=m Arginase 2 Deficiency Promotes Neuroinflammation and Pain Behaviors Following Nerve Injury in Mice. causal interaction,unassigned 4,0 3.5.3.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33735314&form=6&db=m Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33936108&form=6&db=m Central Nervous System Barriers Impact Distribution and Expression of iNOS and Arginase-1 in Infiltrating Macrophages During Neuroinflammation. ongoing research,unassigned 2,0 3.5.3.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25678387&form=6&db=m Arginase 1: a potential marker of a common pattern of liver steatosis in HCV and NAFLD children. causal interaction,unassigned 2,0 3.5.3.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26846206&form=6&db=m Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723931&form=6&db=m Arginine/citrulline cycle changes in diet-induced rat model of non-alcoholic fatty liver disease. ongoing research,unassigned 2,0 3.5.3.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33550112&form=6&db=m Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22189190&form=6&db=m Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity. causal interaction,unassigned 4,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763571&form=6&db=m Increased levels of circulating arginase I in overweight compared to normal weight adolescents. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25057910&form=6&db=m Arginase inhibition ameliorates hepatic metabolic abnormalities in obese mice. ongoing research,therapeutic application,unassigned 3,2,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25078625&form=6&db=m Arginase inhibition restores endothelial function in diet-induced obesity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25723054&form=6&db=m Serum fetuin-A and arginase-1 in human obesity model: Is there any interaction between inflammatory status and arginine metabolism? causal interaction,diagnostic usage,unassigned 3,2,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26188090&form=6&db=m Arginase inhibition ameliorates adipose tissue inflammation in mice with diet-induced obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26840628&form=6&db=m ADMA elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbid obese humans. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27233965&form=6&db=m The Ron Receptor Tyrosine Kinase Regulates Macrophage Heterogeneity and Plays a Protective Role in Diet-Induced Obesity, Atherosclerosis, and Hepatosteatosis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28218737&form=6&db=m Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung. ongoing research,unassigned 1,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808255&form=6&db=m Critical role for arginase 2 in obesity-associated pancreatic cancer. causal interaction,unassigned 2,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048462&form=6&db=m Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29098611&form=6&db=m Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and L-arginine metabolism in mice. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354211&form=6&db=m Aging Modulates the Influence of Arginase on Endothelial Dysfunction in Obesity. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844720&form=6&db=m Mechanisms of obesity-induced metabolic and vascular dysfunctions. causal interaction,unassigned 2,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30909461&form=6&db=m Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice. causal interaction,unassigned 2,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785959&form=6&db=m Improvement in endothelial function in cardiovascular disease - Is arginase the target? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31842363&form=6&db=m Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31979105&form=6&db=m Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity. causal interaction,unassigned 2,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32313729&form=6&db=m The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33961860&form=6&db=m Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Obesity, Morbid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26840628&form=6&db=m ADMA elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbid obese humans. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Obesity, Morbid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30949772&form=6&db=m Microvascular Endothelial Dysfunction in Patients with Obesity. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Oligospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30204347&form=6&db=m THE PECULIARITIES OF ARGINASE PATHWAY OF L-ARGININE IN SPERMATOZOA IN MEN WITH DIFFERENT FORMS OF PATHOSPERMIA. causal interaction,unassigned 3,0 3.5.3.1 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29981582&form=6&db=m Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma. causal interaction,unassigned 1,0 3.5.3.1 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30618589&form=6&db=m Retinal Neuroprotection From Optic Nerve Trauma by Deletion of Arginase 2. diagnostic usage,therapeutic application,unassigned 1,1,0 3.5.3.1 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32052258&form=6&db=m Integrin CD11b Deficiency Aggravates Retinal Microglial Activation and RGCs Degeneration After Acute Optic Nerve Injury. causal interaction,unassigned 3,0 3.5.3.1 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33735314&form=6&db=m Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 ornithine aminotransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513445&form=6&db=m Biomarkers identified in inborn errors for lysine, arginine, and ornithine. causal interaction,unassigned 4,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1404883&form=6&db=m [The dibasic amino acid metabolic disorders] causal interaction,unassigned 3,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15798789&form=6&db=m Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004862&form=6&db=m Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324524&form=6&db=m Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate. diagnostic usage,unassigned 2,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28608518&form=6&db=m Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders. causal interaction,unassigned 3,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 ornithine carbamoyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232532&form=6&db=m Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan. unassigned - 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1404883&form=6&db=m [The dibasic amino acid metabolic disorders] causal interaction,unassigned 3,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164414&form=6&db=m Genetic approach to prenatal diagnosis in urea cycle defects. causal interaction,unassigned 4,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15798789&form=6&db=m Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004862&form=6&db=m Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324524&form=6&db=m Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate. diagnostic usage,unassigned 2,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215558&form=6&db=m Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. causal interaction,unassigned 4,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28608518&form=6&db=m Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders. causal interaction,unassigned 3,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614409&form=6&db=m Physical, cognitive, and social status of patients with urea cycle disorders in Japan. causal interaction,unassigned 2,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840128&form=6&db=m Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. causal interaction,unassigned 3,0 3.5.3.1 Ornithine Carbamoyltransferase Deficiency Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232532&form=6&db=m Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan. unassigned - 3.5.3.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11593962&form=6&db=m Arginase levels are increased in patients with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.5.3.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30610061&form=6&db=m Critical role for arginase II in osteoarthritis pathogenesis. causal interaction,unassigned 3,0 3.5.3.1 Osteomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30711175&form=6&db=m Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice. unassigned - 3.5.3.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23365669&form=6&db=m Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.5.3.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27475813&form=6&db=m Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28330951&form=6&db=m Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18824264&form=6&db=m Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression. diagnostic usage,unassigned 3,0 3.5.3.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29751991&form=6&db=m Influence of CA125, platelet count and neutrophil to lymphocyte ratio on the immune system of ovarian cancer patients. diagnostic usage,unassigned 4,0 3.5.3.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30887252&form=6&db=m Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33423701&form=6&db=m Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.5.3.1 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763571&form=6&db=m Increased levels of circulating arginase I in overweight compared to normal weight adolescents. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10194554&form=6&db=m Growth inhibitory effect of L-canavanine against MIA PaCa-2 pancreatic cancer cells is not due to conversion to its toxic metabolite canaline. unassigned - 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15058249&form=6&db=m [Usefulness of preoperative assay of arginase in pancreatic cancer patients] diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,3,0 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405289&form=6&db=m [Arginase activity in blood serum of patients with acute and chronic pancreatitis] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20856806&form=6&db=m Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23424623&form=6&db=m Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310970&form=6&db=m uPAR induces expression of transforming growth factor ? and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages. causal interaction,ongoing research,unassigned 1,1,0 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26818550&form=6&db=m Circulating myeloid-derived suppressor cells in patients with pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27425386&form=6&db=m Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms: ?A Potential Diagnostic Pitfall. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808255&form=6&db=m Critical role for arginase 2 in obesity-associated pancreatic cancer. causal interaction,unassigned 2,0 3.5.3.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131176&form=6&db=m Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,3 3.5.3.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4710424&form=6&db=m [Rat liver arginase activity in acute experimental pancreatitis] diagnostic usage,ongoing research,unassigned 1,4,0 3.5.3.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4722321&form=6&db=m [Changes of serum arginase in patients with acute cholecystitis and pancreatitis] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697209&form=6&db=m Inhibition of arginase activity ameliorates L-arginine-induced acute pancreatitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.5.3.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405289&form=6&db=m [Arginase activity in blood serum of patients with acute and chronic pancreatitis] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 3.5.3.1 pantoate-beta-alanine ligase (amp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324524&form=6&db=m Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate. diagnostic usage,unassigned 2,0 3.5.3.1 pantoate-beta-alanine ligase (amp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29423830&form=6&db=m Biochemical markers and neuropsychological functioning in distal urea cycle disorders. causal interaction,unassigned 4,0 3.5.3.1 pantoate-beta-alanine ligase (amp-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29948653&form=6&db=m Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment. causal interaction,unassigned 4,0 3.5.3.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=164740&form=6&db=m Unsuccessful trial of gene replacement in arginase deficiency. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1909938&form=6&db=m Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas. diagnostic usage,therapeutic application,unassigned 3,1,0 3.5.3.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4331282&form=6&db=m [Purification and properties of L-arginase of papillomas induced with the rabbit papilloma virus] ongoing research,unassigned 2,0 3.5.3.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6022698&form=6&db=m On the arginase of the Shope papillomas. ongoing research,unassigned 1,0 3.5.3.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13982404&form=6&db=m Studies of the mechanism of action of the Shope rabbit papilloma virus. I. Concerning the nature of the induction of arginase in the infected cells. ongoing research,unassigned 3,0 3.5.3.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14438381&form=6&db=m Induction of arginase in rabbit epithelium by the Shope rabbit papilloma virus. ongoing research,unassigned 2,0 3.5.3.1 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777806&form=6&db=m [A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta] causal interaction,unassigned 3,0 3.5.3.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123990&form=6&db=m Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187023&form=6&db=m Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21051863&form=6&db=m Rat models to investigate host macrophage defense against Trypanosoma cruzi. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.5.3.1 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28268114&form=6&db=m S. mansoni-T. cruzi co-infection modulates arginase-1/iNOS expression, liver and heart disease in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.5.3.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20029630&form=6&db=m Arginase in parasitic infections: macrophage activation, immunosuppression, and intracellular signals. causal interaction,unassigned 2,0 3.5.3.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22246861&form=6&db=m Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses. causal interaction,unassigned 3,0 3.5.3.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23583962&form=6&db=m Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. ongoing research,therapeutic application,unassigned 2,4,0 3.5.3.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32233066&form=6&db=m Thin-layer chromatography-bioautographic method for the detection of arginase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33916228&form=6&db=m Arginase Activity in Eisenia andrei Coelomocytes: Function in the Earthworm Innate Response. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Pemphigus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556586&form=6&db=m Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO. ongoing research,unassigned 4,0 3.5.3.1 Pemphigus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33528891&form=6&db=m Arginase 1+ IL-10+ polymorphonuclear myeloid-derived suppressor cells are elevated in patients with active pemphigus and correlate with an increased Th2/Th1 response. causal interaction,unassigned 3,0 3.5.3.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11218511&form=6&db=m Salivary arginase in patients with adult periodontitis. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11218511&form=6&db=m Salivary arginase in patients with adult periodontitis. causal interaction,ongoing research,unassigned 4,4,0 3.5.3.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20831369&form=6&db=m Arginine-Nitric Oxide-Polyamine Metabolism in Periodontal Disease. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964440&form=6&db=m Arginase deficiency with new phenotype and a novel mutation: contemporary summary. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15133006&form=6&db=m Decreased exhaled nitric oxide as a marker of postinsult immune paralysis. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17167352&form=6&db=m Decrease in lung nitric oxide production after peritonitis in mice with sickle cell disease. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32019673&form=6&db=m Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6. causal interaction,unassigned 4,0 3.5.3.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171478&form=6&db=m Corrigendum to "Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6" [Cell. Immunol. 349 (2020) 104047]. unassigned - 3.5.3.1 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186186&form=6&db=m Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.5.3.1 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709924&form=6&db=m Suppression of T-cell functions by human granulocyte arginase. ongoing research,unassigned 1,0 3.5.3.1 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21636918&form=6&db=m Crystallization and preliminary crystallographic studies of Helicobacter pylori arginase. unassigned - 3.5.3.1 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31177351&form=6&db=m Nitric oxide production is downregulated during respiratory syncytial virus persistence by constitutive expression of arginase 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.1 phenylalanine 4-monooxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3572445&form=6&db=m Biopterins in arginase, dihydropteridine reductase and phenylalanine hydroxylase deficiency. unassigned - 3.5.3.1 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3572445&form=6&db=m Biopterins in arginase, dihydropteridine reductase and phenylalanine hydroxylase deficiency. unassigned - 3.5.3.1 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3760903&form=6&db=m Arginase deficiency and phenylketonuria. unassigned - 3.5.3.1 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30887278&form=6&db=m Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis. causal interaction,therapeutic application,unassigned 2,4,0 3.5.3.1 Pleural Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786901&form=6&db=m A potential role for nitric oxide pathway in tuberculous pleural effusion. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Pneumococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789453&form=6&db=m Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786901&form=6&db=m A potential role for nitric oxide pathway in tuberculous pleural effusion. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17365572&form=6&db=m Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18087596&form=6&db=m In utero environmental tobacco smoke exposure alters gene expression in lungs of adult BALB/c mice. unassigned - 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18403600&form=6&db=m A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. causal interaction,unassigned 4,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18439639&form=6&db=m Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. causal interaction,ongoing research,unassigned 4,2,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19027033&form=6&db=m Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200399&form=6&db=m Human eosinophil granulocytes do not express the enzyme arginase. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23637937&form=6&db=m Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. causal interaction,ongoing research,unassigned 3,4,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23831616&form=6&db=m Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice. causal interaction,ongoing research,unassigned 3,2,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563530&form=6&db=m Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595185&form=6&db=m Effect of arginase inhibition on pulmonary L-arginine metabolism in murine pseudomonas pneumonia. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925982&form=6&db=m Lung arginase expression and activity is increased in cystic fibrosis mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26571397&form=6&db=m Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. causal interaction,unassigned 2,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27043409&form=6&db=m Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29183288&form=6&db=m Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31293566&form=6&db=m The Inhibition of Caspase-1- Does Not Revert Particulate Matter (PM)-Induced Lung Immunesuppression in Mice. causal interaction,unassigned 1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32589266&form=6&db=m MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278710&form=6&db=m Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414508&form=6&db=m Vagal-?7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. causal interaction,therapeutic application,unassigned 4,2,0 3.5.3.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34322123&form=6&db=m Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4. unassigned - 3.5.3.1 Pneumoperitoneum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26415531&form=6&db=m The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.5.3.1 Pneumoperitoneum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26632407&form=6&db=m Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats. ongoing research,unassigned 3,0 3.5.3.1 Pneumoperitoneum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27964711&form=6&db=m Erratum to: The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744923&form=6&db=m L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species. diagnostic usage,unassigned 3,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19012693&form=6&db=m Plasma nitric oxide, endothelin-1, arginase and superoxide dismutase in pre-eclamptic women. causal interaction,unassigned 4,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684035&form=6&db=m Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687346&form=6&db=m Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23223087&form=6&db=m Influence of the AT(2) receptor on the L-arginine-nitric oxide pathway and effects of (-)-epicatechin on HUVECs from women with preeclampsia. diagnostic usage,ongoing research,unassigned 3,4,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29548823&form=6&db=m Arginase controls soluble vascular endothelial growth factor receptor 1 (sFlt1) to maintain pregnancy homeostasis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29763854&form=6&db=m Inhibition of pregnancy-associated granulocytic myeloid-derived suppressor cell expansion and arginase-1 production in preeclampsia. causal interaction,unassigned 2,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33657586&form=6&db=m Red blood cells from patients with pre-eclampsia induce endothelial dysfunction. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33676021&form=6&db=m Effects of arginase genetic polymorphisms on nitric oxide formation in healthy pregnancy and in preeclampsia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33713637&form=6&db=m Different profiles of circulating arginase 2 in subtypes of preeclampsia pregnant women. therapeutic application,unassigned 1,0 3.5.3.1 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578463&form=6&db=m Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29168171&form=6&db=m The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100. unassigned - 3.5.3.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578463&form=6&db=m Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 3.5.3.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30923090&form=6&db=m Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in etiology. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20407034&form=6&db=m Pegylated arginase I: a potential therapeutic approach in T-ALL. therapeutic application,unassigned 4,0 3.5.3.1 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23574711&form=6&db=m Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Priapism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28248201&form=6&db=m Intravascular hemolysis and the pathophysiology of sickle cell disease. causal interaction,unassigned 3,0 3.5.3.1 Prolidase Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3709569&form=6&db=m Increased manganese content and reduced arginase activity in erythrocytes of a patient with prolidase deficiency (iminodipeptiduria). causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Prostatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408309&form=6&db=m Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.5.3.1 Prostatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270424&form=6&db=m Possible implications of arginase and diamine oxidase in prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6189588&form=6&db=m Arginase activity in prostatic tissue of patients with benign prostatic hyperplasia and prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408309&form=6&db=m Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.5.3.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270424&form=6&db=m Possible implications of arginase and diamine oxidase in prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17467&form=6&db=m Some new approaches to potential test systems for drugs against prostatic cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9479597&form=6&db=m Diagnostic performance of serum arginase activity in prostatic cancer. diagnostic usage,unassigned 3,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408309&form=6&db=m Evaluation of serum arginase activity in benign prostatic hypertrophy and prostatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202758&form=6&db=m Expression of arginase II in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528866&form=6&db=m Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18619832&form=6&db=m High expression of indoleamine 2,3-dioxygenase gene in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18663728&form=6&db=m Disruption of arginase II alters prostate tumor formation in TRAMP mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18759245&form=6&db=m Apoptosis-inducing high (.)NO concentrations are not sustained either in nascent or in developed cancers. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19402383&form=6&db=m Expression of immunomodulating genes in prostate cancer and benign prostatic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20711410&form=6&db=m Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843082&form=6&db=m Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity. causal interaction,unassigned 3,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546217&form=6&db=m Deprivation of arginine by recombinant human arginase in prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23424623&form=6&db=m Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28690100&form=6&db=m Arginase purified from endophytic Pseudomonas aeruginosa IH2: Induce apoptosis through both cell cycle arrest and MMP loss in human leukemic HL-60 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.5.3.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30364895&form=6&db=m Altered Cd8+ T lymphocyte Response Triggered by Arginase 1: Implication for Fatigue Intensification during Localized Radiation Therapy in Prostate Cancer Patients. diagnostic usage,therapeutic application,unassigned 1,4,0 3.5.3.1 Protein-Energy Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6421141&form=6&db=m Biochemical changes in saliva of malnourished children. diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Protein-Energy Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25392710&form=6&db=m Protein energy malnutrition increases arginase activity in monocytes and macrophages. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907224&form=6&db=m Effects of Arginase Inhibition in Hypertensive Hyperthyroid Rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Protozoan Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31199070&form=6&db=m Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Pseudomonas Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925982&form=6&db=m Lung arginase expression and activity is increased in cystic fibrosis mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6195857&form=6&db=m Arginase activity and polyamine biosynthesis in psoriasis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.5.3.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507903&form=6&db=m Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation. diagnostic usage,unassigned 3,0 3.5.3.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13627844&form=6&db=m Possible significance of elevated arginase activity in psoriasis scales. diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15780765&form=6&db=m Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.5.3.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32553276&form=6&db=m Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15364894&form=6&db=m Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.5.3.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18991648&form=6&db=m Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders. causal interaction,unassigned 4,0 3.5.3.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23417041&form=6&db=m Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25490411&form=6&db=m Pulmonary Arterial Hypertension in Rats Due to Age-related Arginase Activation in Intermittent Hypoxia. unassigned - 3.5.3.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26126810&form=6&db=m Arginase inhibition protects against hypoxia?induced pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17675371&form=6&db=m Role of nitric oxide synthase/arginase balance in bronchial reactivity in patients with chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437360&form=6&db=m Arginase and pulmonary diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245771&form=6&db=m Increased platelet and erythrocyte arginase activity in chronic obstructive pulmonary disease associated with tobacco or wood smoke exposure. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563530&form=6&db=m Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727374&form=6&db=m Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD). causal interaction,unassigned 3,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122358&form=6&db=m Expansion of myeloid-derived suppressor cells in chronic obstructive pulmonary disease and lung cancer: potential link between inflammation and cancer. diagnostic usage,ongoing research,unassigned 2,2,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27697570&form=6&db=m Metabolomic profiling of doxycycline treatment in chronic obstructive pulmonary disease. diagnostic usage,therapeutic application,unassigned 2,2,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28352168&form=6&db=m Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation. unassigned - 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29729549&form=6&db=m Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833679&form=6&db=m Arginine Therapy for Lung Diseases. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34418988&form=6&db=m Elevated levels of arginase activity are related to inflammation in patients with COPD exacerbation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.5.3.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21281730&form=6&db=m Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism. causal interaction,ongoing research,unassigned 2,3,0 3.5.3.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22079739&form=6&db=m Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism. ongoing research,unassigned 3,0 3.5.3.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26337933&form=6&db=m Leukocyte expression of heme oxygenase-1 [hmox1] varies inversely with severity of tricuspid regurgitation in acute pulmonary embolism. causal interaction,unassigned 2,0 3.5.3.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934065&form=6&db=m Functional role and species-specific contribution of arginases in pulmonary fibrosis. causal interaction,ongoing research,unassigned 2,2,0 3.5.3.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18703795&form=6&db=m Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995084&form=6&db=m Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Quadriplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1463019&form=6&db=m Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Quadriplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6729810&form=6&db=m A successful trial of enzyme replacement therapy in a case of argininemia. causal interaction,unassigned 3,0 3.5.3.1 Quadriplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605507&form=6&db=m Prenatal diagnosis for arginase deficiency: a case study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Reflex, Abnormal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31484827&form=6&db=m Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12475746&form=6&db=m Arginase inhibition slows the progression of renal failure in rats with renal ablation. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24084210&form=6&db=m Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease. ongoing research,unassigned 1,0 3.5.3.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28248201&form=6&db=m Intravascular hemolysis and the pathophysiology of sickle cell disease. causal interaction,unassigned 3,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458774&form=6&db=m Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury. ongoing research,unassigned 4,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074078&form=6&db=m Mechanisms of vasculopathy in sickle cell disease and thalassemia. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20091314&form=6&db=m Direct relationship between levels of TNF-alpha expression and endothelial dysfunction in reperfusion injury. causal interaction,unassigned 3,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23472952&form=6&db=m Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury. therapeutic application,unassigned 4,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062745&form=6&db=m Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction. causal interaction,therapeutic application,unassigned 3,1,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24183975&form=6&db=m Arginase as a target for treatment of myocardial ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072937&form=6&db=m Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963565&form=6&db=m The Promise of Plant-Derived Substances as Inhibitors of Arginase. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28515179&form=6&db=m Arginase-2 mediates renal ischemia-reperfusion injury. causal interaction,ongoing research,unassigned 1,4,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338823&form=6&db=m Arginase-2 protects myocardial ischemia-reperfusion injury via NF-?B/TNF-? pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31561087&form=6&db=m In situ and real-time imaging of superoxide anion and peroxynitrite elucidating arginase 1 nitration aggravating hepatic ischemia-reperfusion injury. unassigned - 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32072766&form=6&db=m Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32739205&form=6&db=m Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress. causal interaction,therapeutic application,unassigned 2,2,0 3.5.3.1 Respiratory Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16185164&form=6&db=m The therapeutic potential of drugs targeting the arginase pathway in asthma. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Respiratory Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269169&form=6&db=m Pharmacological Screening Identifies SHK242 and SHK277 as Novel Arginase Inhibitors with Efficacy against Allergen-Induced Airway Narrowing In Vitro and In Vivo. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=643733&form=6&db=m [Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure] causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29452101&form=6&db=m Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis. causal interaction,unassigned 4,0 3.5.3.1 Retinopathy of Prematurity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21811615&form=6&db=m Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity. ongoing research,therapeutic application,unassigned 1,1,0 3.5.3.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17159374&form=6&db=m Serum nitrite/nitrate and arginase levels in patients with allergic rhinitis. causal interaction,diagnostic usage,unassigned 2,4,0 3.5.3.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21271567&form=6&db=m Increased expression of arginase I and II in allergic nasal mucosa. causal interaction,unassigned 4,0 3.5.3.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21439134&form=6&db=m The effect of montelukast sodium on serum arginase levels in patients with seasonal allergic rhinitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,2 3.5.3.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30865303&form=6&db=m Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis. causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Rhinitis, Allergic, Seasonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21439134&form=6&db=m The effect of montelukast sodium on serum arginase levels in patients with seasonal allergic rhinitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,2 3.5.3.1 Root Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27811065&form=6&db=m Cellular and Molecular Pathways Leading to External Root Resorption. therapeutic application,unassigned 1,0 3.5.3.1 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13575858&form=6&db=m Pathological physiology of salmonellosis. V. Serum arginase and glutamic-oxaloacetic transaminase in children with typhoid fever. unassigned - 3.5.3.1 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18625332&form=6&db=m Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.5.3.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21356378&form=6&db=m M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis. ongoing research,unassigned 3,0 3.5.3.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=444403&form=6&db=m Microenvironmental arginine depletion by macrophages in vivo. ongoing research,unassigned 1,0 3.5.3.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021765&form=6&db=m Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.5.3.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24658839&form=6&db=m Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.5.3.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28969007&form=6&db=m Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.5.3.1 Sarcoma 180 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021765&form=6&db=m Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1032384&form=6&db=m Assessment of serum arginase activity in intestinal and hepatic schistosomiasis. ongoing research,unassigned 3,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714822&form=6&db=m Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18723022&form=6&db=m Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. causal interaction,unassigned 1,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20483789&form=6&db=m Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. ongoing research,therapeutic application,unassigned 3,2,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21810309&form=6&db=m Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages. ongoing research,unassigned 4,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25007099&form=6&db=m Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis. causal interaction,therapeutic application,unassigned 1,4,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25127857&form=6&db=m Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. causal interaction,ongoing research,unassigned 2,2,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25211233&form=6&db=m Incomplete deletion of IL-4R? by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. ongoing research,unassigned 2,0 3.5.3.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034399&form=6&db=m Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model. ongoing research,unassigned 1,0 3.5.3.1 Schistosomiasis mansoni http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25786588&form=6&db=m Arginase activity in peripheral blood of patients with intestinal schistosomiasis, Wonji, Central Ethiopia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.5.3.1 Scrapie http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1983181&form=6&db=m Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis. diagnostic usage,ongoing research,unassigned 4,4,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6729810&form=6&db=m A successful trial of enzyme replacement therapy in a case of argininemia. causal interaction,unassigned 3,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7967487&form=6&db=m Arginase deficiency presenting with convulsions. unassigned - 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8099325&form=6&db=m Manganese and epilepsy: brain glutamine synthetase and liver arginase activities in genetically epilepsy prone and chronically seizured rats. diagnostic usage,ongoing research,unassigned 4,2,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605507&form=6&db=m Prenatal diagnosis for arginase deficiency: a case study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17509462&form=6&db=m Effects of febrile and afebrile seizures on oxidant state in children. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20492947&form=6&db=m Functional significance of the activities of glutaminase and ornithine-?-aminotransferase in rat brain. diagnostic usage,ongoing research,unassigned 1,1,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20853599&form=6&db=m Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23920045&form=6&db=m Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123990&form=6&db=m Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26358771&form=6&db=m Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335400&form=6&db=m Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. causal interaction,unassigned 4,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570396&form=6&db=m Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity. therapeutic application,unassigned 1,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27898091&form=6&db=m Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33325055&form=6&db=m Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency. causal interaction,unassigned 4,0 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1377998&form=6&db=m Hepatic glutamine metabolism in the septic rat. causal interaction,diagnostic usage,unassigned 3,3,0 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635249&form=6&db=m Differential expression of arginase and iNOS in the lung in sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11950832&form=6&db=m Regulation of T cell receptor CD3zeta chain expression by L-arginine. therapeutic application,unassigned 1,0 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513447&form=6&db=m Arginine and immunity. causal interaction,unassigned 4,0 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21921834&form=6&db=m Pseudomonas aeruginosa is associated with increased lung cytokines and asymmetric dimethylarginine compared with methicillin-resistant Staphylococcus aureus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166672&form=6&db=m Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25084831&form=6&db=m Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32849560&form=6&db=m Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34417666&form=6&db=m Immunotherapy-on-Chip Against an Experimental Sepsis Model. causal interaction,diagnostic usage,unassigned 1,2,0 3.5.3.1 Silicosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17365572&form=6&db=m Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Skin Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18271400&form=6&db=m [Clinical and biochemical alterations in rats treated with high doses of vitamin A] causal interaction,diagnostic usage,unassigned 3,1,0 3.5.3.1 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24714832&form=6&db=m Arginase activity and nitric oxide levels in patients with obstructive sleep apnea syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155941&form=6&db=m Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.5.3.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427725&form=6&db=m Contactin 1 modulates pegylated arginase resistance in small cell lung cancer through induction of epithelial-mesenchymal transition. therapeutic application,unassigned 1,0 3.5.3.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393062&form=6&db=m Arginase Pathway Markers of Immune-Microenvironment in Thymic Epithelial Tumors and Small Cell Lung Cancer. causal interaction,diagnostic usage,unassigned 2,3,0 3.5.3.1 Spinal Cord Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408267&form=6&db=m Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18358516&form=6&db=m Nitric oxide-mediated suppression of detrusor overactivity by arginase inhibitor in rats with chronic spinal cord injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 3.5.3.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22798716&form=6&db=m Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.5.3.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26150769&form=6&db=m Looking downstream: the role of cyclic AMP-regulated genes in axonal regeneration. therapeutic application,unassigned 4,0 3.5.3.1 Spinal Cord Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29415995&form=6&db=m Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state. diagnostic usage,unassigned 4,0 3.5.3.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24715304&form=6&db=m Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.5.3.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904129&form=6&db=m The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.5.3.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26514486&form=6&db=m Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.5.3.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26740106&form=6&db=m Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells. unassigned - 3.5.3.1 ST Elevation Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33420142&form=6&db=m The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance. diagnostic usage,ongoing research,unassigned 2,3,0 3.5.3.1 ST Elevation Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34237174&form=6&db=m Arginase 1 is upregulated at admission in patients with ST-elevation myocardial infarction. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 3.5.3.1 Staphylococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32849560&form=6&db=m Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=239678&form=6&db=m Molecular charcteristics of chicken kidney arginase. therapeutic application,unassigned 1,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=362156&form=6&db=m Catabolic synergism: a cooperation between the availability of substrate and the need for nitrogen in the regulation of arginine catabolism in Saccharomyces cerevisiae. unassigned - 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=583583&form=6&db=m Effects of cortisol or starvation on the activities of four enzymes in small intestine and liver of the rat during development. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4222567&form=6&db=m The effect of adrenalectomy and starvation on arginase and ornithine-transcarbamylase activities in the liver of rats during development. ongoing research,unassigned 4,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4370648&form=6&db=m Intramitochondrial localization of arginase appearing in chicken liver upon starvation. unassigned - 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6202256&form=6&db=m Distribution of amino acids and amino-acid enzymes in whole kidney and renal cortex. Effect of 24-h starvation. unassigned - 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7020588&form=6&db=m induction and derepression of arginase and ornithine transaminase in different strains of Saccharomyces cerevisiae. unassigned - 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529191&form=6&db=m Arginase activity is a useful marker of nitrogen limitation during alcoholic fermentations. diagnostic usage,therapeutic application,unassigned 2,2,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152246&form=6&db=m Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21931552&form=6&db=m Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. unassigned - 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114701&form=6&db=m Axenic Leishmania amazonensis promastigotes sense both the external and internal arginine pool distinctly regulating the two transporter-coding genes. diagnostic usage,therapeutic application,unassigned 3,1,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26202519&form=6&db=m Capillary electrophoresis reveals polyamine metabolism modulation in Leishmania (Leishmania) amazonensis wild type and arginase knockout mutants under arginine starvation. ongoing research,therapeutic application,unassigned 2,1,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28040060&form=6&db=m Oxidative stress and some biochemical parameters during starvation and refeeding in Astacus leptodactylus (Esch., 1823). diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30993582&form=6&db=m Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.3.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666335&form=6&db=m An arginase-based system for selection of transfected CHO cells without the use of toxic chemicals. ongoing research,unassigned 4,0 3.5.3.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961243&form=6&db=m Recurrent hepatic failure and status epilepticus: an uncommon presentation of hyperargininemia. causal interaction,unassigned 4,0 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1406053&form=6&db=m Regulation of arginase production by glucocorticoid in three human gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2819664&form=6&db=m Content of glucocorticoid receptor and arginase in gastric cancer and normal gastric mucosal tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3449318&form=6&db=m The effects of arginase on neoplasm. I. The role of arginase in the immunosuppressive effects of extract from gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8113593&form=6&db=m Serum arginase level in patients with gastric cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8174424&form=6&db=m Effect of arginase on splenic killer cell activity in patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797936&form=6&db=m Immunohistochemical study of arginase in cancer of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31801938&form=6&db=m Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer. diagnostic usage,unassigned 2,0 3.5.3.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32415175&form=6&db=m Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells. causal interaction,ongoing research,unassigned 1,2,0 3.5.3.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797936&form=6&db=m Immunohistochemical study of arginase in cancer of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.5.3.1 Strabismus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32025996&form=6&db=m Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18480737&form=6&db=m [New insights into arginase. Part II. Role in physiology and pathology] causal interaction,unassigned 4,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23311438&form=6&db=m Effect of stroke on arginase expression and localization in the rat brain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24793492&form=6&db=m Pair housing reverses post-stroke depressive behavior in mice. causal interaction,unassigned 4,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25966956&form=6&db=m Arginase I release from activated neutrophils induces peripheral immunosuppression in a murine model of stroke. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29600431&form=6&db=m Effectiveness of arginase inhibitors against experimentally induced stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30112629&form=6&db=m Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033258&form=6&db=m Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy? causal interaction,therapeutic application,unassigned 3,4,0 3.5.3.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32832192&form=6&db=m CD4 T cell deficiency attenuates ischemic stroke, inhibits oxidative stress, and enhances Akt/mTOR survival signaling pathways in mice. causal interaction,ongoing research,unassigned 3,2,0 3.5.3.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18068544&form=6&db=m Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit. causal interaction,ongoing research,unassigned 2,1,0 3.5.3.1 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26538654&form=6&db=m Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. ongoing research,unassigned 1,0 3.5.3.1 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25071759&form=6&db=m Embryonic Stem Cells Promoting Macrophage Survival and Function are Crucial for Teratoma Development. causal interaction,unassigned 3,0 3.5.3.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8691729&form=6&db=m L-arginine depletion inhibits glomerular nitric oxide synthesis and exacerbates rat nephrotoxic nephritis. causal interaction,unassigned 1,0 3.5.3.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17116549&form=6&db=m Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis. causal interaction,ongoing research,unassigned 4,3,0 3.5.3.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18486420&form=6&db=m Arginase blockade lessens endothelial dysfunction after thrombosis. ongoing research,unassigned 4,0 3.5.3.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032511&form=6&db=m Thrombin induces endothelial arginase through AP-1 activation. causal interaction,therapeutic application,unassigned 3,3,0 3.5.3.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26146124&form=6&db=m Mature coconut water exhibits antidiabetic and antithrombotic potential via L-arginine-nitric oxide pathway in alloxan induced diabetic rats. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28785178&form=6&db=m Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,2 3.5.3.1 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25294815&form=6&db=m Melanoma-initiating cells exploit M2 macrophage TGF? and arginase pathway for survival and proliferation. ongoing research,unassigned 1,0 3.5.3.1 Toxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1619856&form=6&db=m [The effect of antiprotein plasma on humoral resistance in children with severe burns] diagnostic usage,unassigned 2,0 3.5.3.1 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23691079&form=6&db=m Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.5.3.1 Tremor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25474440&form=6&db=m Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501824&form=6&db=m Blocking autophagy enhanced cytotoxicity induced by recombinant human arginase in triple-negative breast cancer cells. ongoing research,therapeutic application,unassigned 4,4,0 3.5.3.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30362115&form=6&db=m Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.5.3.1 Trypanosomiasis, African http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23554207&form=6&db=m Serum arginase, a biomarker of treatment efficacy in human African trypanosomiasis. diagnostic usage,therapeutic application,unassigned 4,4,0 3.5.3.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786901&form=6&db=m A potential role for nitric oxide pathway in tuberculous pleural effusion. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.5.3.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22827286&form=6&db=m Arginase-1 expression in granulomas of tuberculosis patients. diagnostic usage,ongoing research,unassigned 4,3,0 3.5.3.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354980&form=6&db=m Small-molecule arginase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25201986&form=6&db=m Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. ongoing research,unassigned 3,0 3.5.3.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26571397&form=6&db=m Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. causal interaction,unassigned 2,0 3.5.3.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27534685&form=6&db=m Adaptation of M. tuberculosis to impaired host immunity in HIV-infected patients. diagnostic usage,unassigned 3,0 3.5.3.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29176982&form=6&db=m Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis. causal interaction,therapeutic application,unassigned 1,1,0 3.5.3.1 Tumor Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4331301&form=6&db=m Change in the structure of Shope papilloma virus-induced arginase associated with mutation of the virus. unassigned - 3.5.3.1 Tumor Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4348278&form=6&db=m Induction of arginase activity with the Shope papilloma virus in tissue culture cells from an argininemic patient. ongoing research,unassigned 4,0 3.5.3.1 Tumor Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6053146&form=6&db=m Studies on the arginase activity of Shope papilloma: possible presence of isozymes. diagnostic usage,ongoing research,unassigned 1,2,0 3.5.3.1 Tumor Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14293300&form=6&db=m USE OF THE SHOPE PAPILLOMA VIRUS-INDUCED ARGINASE AS A BIOCHEMICAL MARKER IN VITRO. diagnostic usage,unassigned 4,0 3.5.3.1 Typhoid Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13575858&form=6&db=m Pathological physiology of salmonellosis. V. Serum arginase and glutamic-oxaloacetic transaminase in children with typhoid fever. unassigned - 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8454280&form=6&db=m Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme. causal interaction,unassigned 4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9378897&form=6&db=m Argininemia: a treatable genetic cause of progressive spastic diplegia simulating cerebral palsy: case reports and literature review. causal interaction,unassigned 4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771848&form=6&db=m Arginase deficiency. causal interaction,unassigned 3,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15798789&form=6&db=m Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. causal interaction,diagnostic usage,unassigned 1,1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935537&form=6&db=m Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines. causal interaction,ongoing research,unassigned 4,1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16963300&form=6&db=m A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation. therapeutic application,unassigned 3,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20176499&form=6&db=m Guanidino compound levels in blood, cerebrospinal fluid, and post-mortem brain material of patients with argininemia. unassigned - 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22760543&form=6&db=m Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23388701&form=6&db=m AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse. causal interaction,unassigned 1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25611620&form=6&db=m Anesthetic management of a patient with arginase deficiency undergoing liver transplantation. therapeutic application,unassigned 1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26358771&form=6&db=m Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27038030&form=6&db=m Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335400&form=6&db=m Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. causal interaction,unassigned 4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28892883&form=6&db=m A Case of Hyperargininaemia Presenting at Unusually Low Age. causal interaction,unassigned 4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187023&form=6&db=m Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. causal interaction,therapeutic application,unassigned 2,1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29726057&form=6&db=m Mutations and common variants in the human arginase 1 (ARG1) gene: Impact on patients, diagnostics, and protein structure considerations. causal interaction,unassigned 1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923457&form=6&db=m Arginase I mRNA therapy - a novel approach to rescue arginase 1 enzyme deficiency. causal interaction,unassigned 4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31649772&form=6&db=m Arginase Deficiency Presenting as Acute Encephalopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32025996&form=6&db=m Anesthetic management of a pediatric patient with arginase-1 deficiency undergoing strabismus operation: a case report. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32770317&form=6&db=m Neurological Deterioration in Three Siblings: Exploring the Spectrum of Argininemia. causal interaction,unassigned 4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33561495&form=6&db=m Arginase-1 deficiency in neural cells does not contribute to neurodevelopment or functional outcomes after sciatic nerve injury. causal interaction,unassigned 4,0 3.5.3.1 Urea Cycle Disorders, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471603&form=6&db=m Creatine metabolism in patients with urea cycle disorders. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=473674&form=6&db=m [Effect of flavonoids on aspects of nitrogen metabolism in experimental uremia] unassigned - 3.5.3.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1231923&form=6&db=m Arginase activity of human erythrocyte ghosts in uremia. ongoing research,unassigned 2,0 3.5.3.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13018724&form=6&db=m [Hepatic and renal arginase in uremia; experimental study in uremia produced by ligation of the ureters in guinea pig.] ongoing research,unassigned 2,0 3.5.3.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14803458&form=6&db=m Liver arginase activity as related to blood urea in acute uremia of new-born rats. ongoing research,unassigned 3,0 3.5.3.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32956070&form=6&db=m Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis. causal interaction,unassigned 3,0 3.5.3.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791071&form=6&db=m Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells. ongoing research,therapeutic application,unassigned 3,3,0 3.5.3.1 Urinary Bladder, Neurogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18358516&form=6&db=m Nitric oxide-mediated suppression of detrusor overactivity by arginase inhibitor in rats with chronic spinal cord injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 3.5.3.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25084511&form=6&db=m Immunosuppression in cervical cancer with special reference to arginase activity. unassigned - 3.5.3.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050217&form=6&db=m Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 3.5.3.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470967&form=6&db=m Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats. unassigned - 3.5.3.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19590038&form=6&db=m Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29752572&form=6&db=m Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis. ongoing research,therapeutic application,unassigned 4,1,0 3.5.3.1 Uveitis, Anterior http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19590038&form=6&db=m Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.5.3.1 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25890347&form=6&db=m Major protein alterations in spermatozoa from infertile men with unilateral varicocele. unassigned - 3.5.3.1 Varicose Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10918219&form=6&db=m Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17223136&form=6&db=m Time course of vascular arginase expression and activity in spontaneously hypertensive rats. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645639&form=6&db=m Arginase: a critical regulator of nitric oxide synthesis and vascular function. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19997976&form=6&db=m The Redox State of the Glutathione/Glutathione Disulfide Couple Mediates Intracellular Arginase Activation in HCT-116 Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20563744&form=6&db=m Endothelial arginase II responds to pharmacological inhibition by elevation in protein level. therapeutic application,unassigned 1,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861464&form=6&db=m HYPOXIC UPREGULATION OF ARGINASE II IN HUMAN LUNG ENDOTHELIAL CELLS. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21860744&form=6&db=m Endothelial arginase II and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21918827&form=6&db=m Oxidant-mediated modification of the cellular thiols is sufficient for arginase activation in cultured cells. causal interaction,unassigned 4,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717158&form=6&db=m Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling. therapeutic application,unassigned 1,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717309&form=6&db=m Role of arginase in vessel wall remodeling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966996&form=6&db=m Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24757370&form=6&db=m Korean red ginseng water extract restores impaired endothelial function by inhibiting arginase activity in aged mice. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25445030&form=6&db=m Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia. causal interaction,therapeutic application,unassigned 4,1,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26265320&form=6&db=m A Novel Arginase Inhibitor Derived from Scutellavia indica Restored Endothelial Function in ApoE-Null Mice Fed a High-Cholesterol Diet. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26586660&form=6&db=m Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27392245&form=6&db=m Arginase Inhibitor 2,3,5,4'-Tetrahydroxystilbene-2-O-?-D-Glucoside Activates Endothelial Nitric Oxide Synthase and Improves Vascular Function. diagnostic usage,unassigned 3,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450233&form=6&db=m Insights on the participation of Glu256 and Asp204 in the oligomeric structure and cooperative effects of human arginase type I. causal interaction,therapeutic application,unassigned 4,3,0 3.5.3.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527178&form=6&db=m Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29472234&form=6&db=m Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium. causal interaction,therapeutic application,unassigned 4,4,0 3.5.3.1 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19415488&form=6&db=m Melatonin Ameliorates Cerebral Vasospasm After Experimental Subarachnoidal Haemorrhage Correcting Imbalance of Nitric Oxide Levels in Rats. causal interaction,diagnostic usage,unassigned 4,2,0 3.5.3.1 Venous Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10918219&form=6&db=m Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.5.3.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6319272&form=6&db=m Contribution of macrophage arginase in the intrinsic restriction of herpes simplex virus replication in permissive macrophage cultures induced by gamma-interferon containing products of activated spleen cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.5.3.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592089&form=6&db=m Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis. ongoing research,therapeutic application,unassigned 3,1,0 3.5.3.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26829838&form=6&db=m [SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.5.3.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27770558&form=6&db=m Expression of scavenger receptor-AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis. unassigned - 3.5.3.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31177351&form=6&db=m Nitric oxide production is downregulated during respiratory syncytial virus persistence by constitutive expression of arginase 1. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.5.3.1 Vitamin A Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1213864&form=6&db=m Influence of vitamin A on formation and excretion of end products of nitrogen catabolism in chicks. causal interaction,unassigned 2,0 3.5.3.1 Vitamin B 12 Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31546940&form=6&db=m Involvement of Spermidine in the Reduced Lifespan of Caenorhabditis elegans During Vitamin B12 Deficiency. causal interaction,unassigned 4,0 3.5.3.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779022&form=6&db=m Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis. ongoing research,unassigned 4,0 3.5.3.1 xaa-pro dipeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3709569&form=6&db=m Increased manganese content and reduced arginase activity in erythrocytes of a patient with prolidase deficiency (iminodipeptiduria). causal interaction,diagnostic usage,unassigned 1,3,0 3.5.3.1 Xanthomatosis, Cerebrotendinous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777806&form=6&db=m [A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta] causal interaction,unassigned 3,0