3.5.1.19 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10531245&form=6&db=m Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections. ongoing research,therapeutic application,unassigned 2,1,0 3.5.1.19 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32766170&form=6&db=m The NAD+ Responsive Transcription Factor ERM-BP Functions Downstream of Cellular Aggregation and Is an Early Regulator of Development and Heat Shock Response in Entamoeba. causal interaction,therapeutic application,unassigned 1,1,0 3.5.1.19 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694619&form=6&db=m A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. therapeutic application,unassigned 1,0 3.5.1.19 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119559&form=6&db=m Defining plasmids required by Borrelia burgdorferi for colonization of tick vector Ixodes scapularis (Acari: Ixodidae). unassigned - 3.5.1.19 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31733620&form=6&db=m In silico pharmacophore modeling and simulation studies for searching potent antileishmanials targeted against Leishmania donovani nicotinamidase. unassigned - 3.5.1.19 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3546548&form=6&db=m Identification of cat leprosy bacillus grown in mice. unassigned - 3.5.1.19 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4259432&form=6&db=m Early effects of nicotinamide, 2,4-dichloro-phenoxy acetic acid & actinomycin-D on the synthesis of nicotinamide amidohydrolase in rumex acetosa tumour tissue. ongoing research,unassigned 1,0 3.5.1.19 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7378417&form=6&db=m Purification and characterization of a nicotinamide deamidase released into the growth medium of neuroblastoma in vitro. ongoing research,unassigned 4,0 3.5.1.19 Photophobia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=506551&form=6&db=m [Nicotinamidase and the so-called pyrazinamidase in mycobacteria; the simultaneous occurrence of both activites (author's transl)] unassigned - 3.5.1.19 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31433182&form=6&db=m Multiscale Computational Study on the Catalytic Mechanism of the Nonmetallo Amidase Maleamate Amidohydrolase (NicF). unassigned - 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=330364&form=6&db=m Cytochemical and biological properties of Mycobacterium bovis BCG. diagnostic usage,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640557&form=6&db=m Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. therapeutic application,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8726014&form=6&db=m Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA. diagnostic usage,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968889&form=6&db=m Rapid differentiation of bovine and human tubercle bacilli based on a characteristic mutation in the bovine pyrazinamidase gene. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9055989&form=6&db=m Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. therapeutic application,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353938&form=6&db=m The pncA gene from naturally pyrazinamide-resistant Mycobacterium avium encodes pyrazinamidase and confers pyrazinamide susceptibility to resistant M. tuberculosis complex organisms. ongoing research,therapeutic application,unassigned 2,1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493394&form=6&db=m Extracellular enzyme activities potentially involved in the pathogenicity of Mycobacterium tuberculosis. diagnostic usage,ongoing research,unassigned 3,1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692180&form=6&db=m Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis. causal interaction,ongoing research,unassigned 1,2,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9811635&form=6&db=m Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis. ongoing research,therapeutic application,unassigned 3,1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10049264&form=6&db=m Reduced pyrazinamidase activity and the natural resistance of Mycobacterium kansasii to the antituberculosis drug pyrazinamide. therapeutic application,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411262&form=6&db=m Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity. therapeutic application,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10681313&form=6&db=m pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada. unassigned - 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10813147&form=6&db=m Molecular characterization of pncA gene mutations in Mycobacterium tuberculosis clinical isolates from China. unassigned - 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429043&form=6&db=m pncA mutations in clinical Mycobacterium tuberculosis isolates from Korea. diagnostic usage,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714269&form=6&db=m Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii. therapeutic application,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12701830&form=6&db=m The curious characteristics of pyrazinamide: a review. unassigned - 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12788027&form=6&db=m An assessment of a multiplex PCR assay for differentiating clinically important mycobacteria based on pncA gene variation. therapeutic application,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13676136&form=6&db=m [Type differentiation of tuberculosis bacteria with the aid of the nicotinamidase test.] diagnostic usage,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17373362&form=6&db=m The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria. causal interaction,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17382284&form=6&db=m Crystal structure of the yeast nicotinamidase Pnc1p. ongoing research,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18201201&form=6&db=m Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase. causal interaction,ongoing research,unassigned 1,4,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19579692&form=6&db=m Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Turkey. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19859929&form=6&db=m Specificity and Mechanism of Acinetobacter baumanii Nicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide. therapeutic application,unassigned 2,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20011149&form=6&db=m Insight to pyrazinamide resistance in Mycobacterium tuberculosis by molecular docking. unassigned - 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20693593&form=6&db=m Comparison of MGIT 960 & pyrazinamidase activity assay for pyrazinamide susceptibility testing of Mycobacterium tuberculosis. diagnostic usage,ongoing research,unassigned 3,3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20879713&form=6&db=m Kinetics and Inhibition of Nicotinamidase from Mycobacterium tuberculosis. ongoing research,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22102918&form=6&db=m Rapid colorimetric testing for pyrazinamide susceptibility of M. tuberculosis by a PCR-based in-vitro synthesized pyrazinamidase method. diagnostic usage,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23390285&form=6&db=m Evaluation of drug susceptibility testing methods of clinical Mycobacterium tuberculosis isolates to pyrazinamide. diagnostic usage,ongoing research,unassigned 3,2,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770140&form=6&db=m Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene. ongoing research,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24226918&form=6&db=m Rapid detection of Mycobacterium tuberculosis and pyrazinamide susceptibility related to pncA mutations in sputum specimens through an integrated gene-to-protein function approach. diagnostic usage,therapeutic application,unassigned 4,1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25199451&form=6&db=m Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds. ongoing research,therapeutic application,unassigned 2,1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25972249&form=6&db=m Biochemical Characterization and Computational Identification of Mycobacterium tuberculosis Pyrazinamidase in Some Pyrazinamide-Resistant Isolates of Iran. causal interaction,ongoing research,unassigned 2,2,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28043510&form=6&db=m Effects of sorbitol and glycerol on the structure, dynamics, and stability of Mycobacterium tuberculosis pyrazinamidase. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28630430&form=6&db=m A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis. unassigned - 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29516881&form=6&db=m Estimation of pyrazinamidase activity using a cell-free diagnostic usage,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189582&form=6&db=m Direct Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis by Use of pncA PCR Sequencing. diagnostic usage,unassigned 3,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357912&form=6&db=m Structural dynamics behind variants in pyrazinamidase and pyrazinamide resistance. therapeutic application,unassigned 1,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31442707&form=6&db=m Revelation of enzyme activity of mutant pyrazinamidases from Mycobacterium tuberculosis upon binding with various metals using quantum mechanical approach. therapeutic application,unassigned 4,0 3.5.1.19 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158237&form=6&db=m Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China. diagnostic usage,therapeutic application,unassigned 4,1,0