3.4.24.77 22q11 Deletion Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17156190&form=6&db=m Could the defects in the endometrial extracellular matrix during the implantation be a cause for impaired fertility? causal interaction,unassigned 3,0 3.4.24.77 Abortion, Missed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830297&form=6&db=m Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830297&form=6&db=m Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25128867&form=6&db=m Association of tissue inhibitor of metalloproteinase gene polymorphisms and unexplained recurrent spontaneous abortions in Han Chinese couples. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33612551&form=6&db=m Biological potentials for a family of disintegrin and metalloproteinase (ADAMDEC)-1 in mouse normal pregnancy. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Abscess http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27542125&form=6&db=m Anti-MMP-9 Antibody: A Promising Therapeutic Strategy for Treatment of Inflammatory Bowel Disease Complications with Fibrosis. causal interaction,unassigned 4,0 3.4.24.77 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085885&form=6&db=m Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21415544&form=6&db=m Augmentation of Gene Expression and Production of Promatrix Metalloproteinase 2 by Propionibacterium acnes-Derived Factors in Hamster Sebocytes and Dermal Fibroblasts: A Possible Mechanism for Acne Scarring. ongoing research,unassigned 1,0 3.4.24.77 Acrodermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18936158&form=6&db=m Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. causal interaction,unassigned 3,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586954&form=6&db=m Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524241&form=6&db=m Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962945&form=6&db=m Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial. causal interaction,therapeutic application,unassigned 2,3,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15093992&form=6&db=m Serum profiles of matrix metalloproteinases and their tissue inhibitor in patients with acute coronary syndromes. The effects of short-term atorvastatin administration. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15369750&form=6&db=m Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531533&form=6&db=m Elevated pregnancy-associated plasma protein-a in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614002&form=6&db=m Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17364896&form=6&db=m Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes. causal interaction,unassigned 3,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17667031&form=6&db=m In-hospital outcome of patients with acute coronary syndrome: relationship with inflammation and remodeling markers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17922333&form=6&db=m Metalloproteinases in Diabetics and Nondiabetics during Acute Coronary Syndromes and after 3 Months. causal interaction,unassigned 2,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19656094&form=6&db=m [Changes in proinflammatory cytokine and destructive metalloproteinase levels during formation of unstable atherosclerotic plaque] causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19944557&form=6&db=m ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22839584&form=6&db=m [Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood]. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23793312&form=6&db=m Transcription activity of MMP-2 and MMP-9 metalloproteinase genes and their tissue inhibitor (TIMP-2) in acute coronary syndrome patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 3.4.24.77 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28747015&form=6&db=m Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7695599&form=6&db=m The role of meprin A in the pathogenesis of acute renal failure. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075185&form=6&db=m Angiostatin and matrix metalloprotease expression following ischemic acute renal failure. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798585&form=6&db=m Urinary biomarkers TIMP-2 and IGFBP7 early predict acute kidney injury after major surgery. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28410274&form=6&db=m Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. therapeutic application,unassigned 1,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28803769&form=6&db=m Urine Biomarkers of Tubular Renal Cell Damage for the Prediction of Acute Kidney Injury After Cardiac Surgery-A Pilot Study. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942494&form=6&db=m Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency. diagnostic usage,unassigned 1,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30376758&form=6&db=m The Accuracy of Urinary TIMP-2 and IGFBP7 for the Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31234668&form=6&db=m Economic and clinical benefits of early identification of acute kidney injury using a urinary biomarker. diagnostic usage,unassigned 3,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33009198&form=6&db=m Urinary cell cycle arrest proteins urinary tissue inhibitor of metalloprotease 2 and insulin-like growth factor binding protein 7 predict acute kidney injury after severe trauma: A prospective observational study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437392&form=6&db=m A Biochemical and Pharmacological Characterization of Phospholipase A2 and Metalloproteinase Fractions from Eastern Russell's Viper (Daboia siamensis) Venom: Two Major Components Associated with Acute Kidney Injury. unassigned - 3.4.24.77 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34541359&form=6&db=m Tissue inhibitor metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) best predicts the development of acute kidney injury. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11435213&form=6&db=m Augmented metalloproteinase activity and acute lung injury in copper-deficient rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.24.77 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687607&form=6&db=m Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 adamts13 endopeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18175284&form=6&db=m Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 adamts13 endopeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20628891&form=6&db=m Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 adamts13 endopeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25512528&form=6&db=m Allosteric activation of ADAMTS13 by von Willebrand factor. unassigned - 3.4.24.77 adamts13 endopeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720178&form=6&db=m Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy. causal interaction,unassigned 4,0 3.4.24.77 adamts13 endopeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30312976&form=6&db=m ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 adamts13 endopeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34495312&form=6&db=m Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura. unassigned - 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1480077&form=6&db=m Association of high level of serum M(r) approximately 92,000 metalloproteinase activity with lung metastasis of rat 13,762 NF mammary adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7586808&form=6&db=m Ultrastructural study of TPA-induced cell motility: human well-differentiated rectal adenocarcinoma cells move as coherent sheets via localized modulation of cell-cell adhesion. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651936&form=6&db=m A two-dimensional model of cell movement. Well differentiated human rectal adenocarcinoma cells move as coherent sheets upon TPA stimulation. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678936&form=6&db=m Immunohistochemical analysis of type IV collagenase expression in prostatic hyperplasia and adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7882342&form=6&db=m Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8068180&form=6&db=m Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253535&form=6&db=m TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1. ongoing research,unassigned 4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712742&form=6&db=m Immunohistochemical evaluation of type IV collagenase (72-kd metalloproteinase) in prostatic intraepithelial neoplasia. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8822116&form=6&db=m Location of 72-kd metalloproteinase (type IV collagenase) in untreated prostatic adenocarcinoma. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10434927&form=6&db=m Metalloproteinases and tissue inhibitor of metalloproteinase 1 (TIMP-1) in endometrial flushings from pre- and post-menopausal women and from women with endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680208&form=6&db=m Transcriptional gene expression profiles of oesophageal adenocarcinoma and normal oesophageal tissues. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716815&form=6&db=m Inhibition of beta-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expression. ongoing research,unassigned 4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502351&form=6&db=m Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982746&form=6&db=m Aberrant Expression of a Disintegrin and Metalloproteinase 17/Tumor Necrosis Factor-{alpha} Converting Enzyme Increases the Malignant Potential in Human Pancreatic Ductal Adenocarcinoma. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17264401&form=6&db=m Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493236&form=6&db=m Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18031395&form=6&db=m Relationship between biomarker expression and allelic alteration in esophageal carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202798&form=6&db=m Tissue inhibitor of metalloproteinase 2 (TIMP-2) expression in adenocarcinoma pleural effusions. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18253117&form=6&db=m Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473733&form=6&db=m Circulating levels of VCAM and MMP-2 may help identify patients with more aggressive prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20840749&form=6&db=m PGF2?-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21983937&form=6&db=m Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203731&form=6&db=m Dual combination therapy targeting DR5 and EMMPRIN in pancreatic adenocarcinoma. ongoing research,unassigned 3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23551625&form=6&db=m Immunohistochemical analysis on potential new molecular targets for esophageal cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23819566&form=6&db=m Promoter methylation and expression of TIMP3 gene in gastric cancer. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28578917&form=6&db=m STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells. ongoing research,unassigned 3,0 3.4.24.77 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30556643&form=6&db=m ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 3.4.24.77 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12044784&form=6&db=m Inhibitory effect of acetylsalicylic acid on metalloproteinase activity in human lung adenocarcinoma at different stages of differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28693193&form=6&db=m Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling. unassigned - 3.4.24.77 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28960861&form=6&db=m Lentivirus-mediated disintegrin and metalloproteinase 17 RNA interference reversed the acquired resistance to gefitinib in lung adenocarcinoma cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.24.77 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002360&form=6&db=m miR?888 regulates cancer progression by targeting multiple targets in lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32732999&form=6&db=m Identification of relevant genetic alterations in cancer using topological data analysis. unassigned - 3.4.24.77 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8548762&form=6&db=m Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10713661&form=6&db=m Induction of matrix metalloprotease-7 is common in mucinous ovarian tumors including early stage disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306456&form=6&db=m CpG island methylation in premalignant stages of gastric carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11173827&form=6&db=m Cell lines from the same cervical carcinoma but with different radiosensitivities exhibit different cDNA microarray patterns of gene expression. ongoing research,unassigned 1,0 3.4.24.77 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18286531&form=6&db=m Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. ongoing research,unassigned 3,0 3.4.24.77 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20572039&form=6&db=m Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25620615&form=6&db=m CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers. unassigned - 3.4.24.77 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30827941&form=6&db=m Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. ongoing research,unassigned 2,0 3.4.24.77 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16468658&form=6&db=m [Expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase in adenomyosis] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.24.77 Adrenocortical Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980949&form=6&db=m Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980949&form=6&db=m Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759224&form=6&db=m Airway obstruction is increased in Pneumocystis-colonized HIV-infected outpatients. ongoing research,unassigned 4,0 3.4.24.77 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587406&form=6&db=m Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. therapeutic application,unassigned 1,0 3.4.24.77 alpha 1-Antitrypsin Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19293200&form=6&db=m Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. causal interaction,unassigned 4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7815076&form=6&db=m Localization of tissue inhibitor of matrix metalloproteinases in Alzheimer's disease and normal brain. unassigned - 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8286339&form=6&db=m Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. ongoing research,unassigned 1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8780030&form=6&db=m Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8993329&form=6&db=m A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments. causal interaction,unassigned 1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453567&form=6&db=m Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells. ongoing research,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10373494&form=6&db=m Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782344&form=6&db=m Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12850277&form=6&db=m Non-covalent interaction of ubiquitin with insulin-degrading enzyme. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16233955&form=6&db=m Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis. diagnostic usage,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16648635&form=6&db=m Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. unassigned - 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047365&form=6&db=m Alpha-secretase activation--an approach to Alzheimer's disease therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17077200&form=6&db=m Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244626&form=6&db=m Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17613531&form=6&db=m Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055214&form=6&db=m Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19127446&form=6&db=m Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element. causal interaction,unassigned 1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19183255&form=6&db=m A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19220854&form=6&db=m The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19679113&form=6&db=m Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19877269&form=6&db=m The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors. causal interaction,unassigned 4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20676056&form=6&db=m ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. unassigned - 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044078&form=6&db=m alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21478884&form=6&db=m SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. therapeutic application,unassigned 2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605033&form=6&db=m Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking. causal interaction,unassigned 4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605036&form=6&db=m The Role of the Anti-Amyloidogenic Secretase ADAM10 in Shedding the APP-Like Proteins. causal interaction,unassigned 1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801775&form=6&db=m Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin ?1; ADAP1) in neuroblastoma cells. causal interaction,unassigned 2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21820649&form=6&db=m Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ?-mediated metalloproteinase 2 and 9 levels in ?-amyloid infused Alzheimer's disease rat model. ongoing research,unassigned 1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21959176&form=6&db=m Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22355395&form=6&db=m Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23676497&form=6&db=m Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. causal interaction,unassigned 2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059320&form=6&db=m Insulin-Degrading Enzyme: A Link between Alzheimer's and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24457647&form=6&db=m Expression of the type 1 metalloproteinase in the rat hippocampus after the intracerebroventricular injection of ?-amyloid peptide (25-35). causal interaction,unassigned 4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26025789&form=6&db=m A neglected modulator of insulin-degrading enzyme activity and conformation: The pH. causal interaction,unassigned 2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26256061&form=6&db=m Expression, purification and initial characterization of human meprin ? from Pichia pastoris. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27060611&form=6&db=m Regulation of the ?-secretase ADAM10 at transcriptional, translational and post-translational levels. unassigned - 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333034&form=6&db=m ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27443962&form=6&db=m Identification and functional characterization of a putative IDE, C28F5.4 (ceIDE-1), in Caenorhabditis elegans: Implications for Alzheimer's disease. causal interaction,unassigned 2,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30133282&form=6&db=m Catalytic Mechanism of Amyloid-? Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30305381&form=6&db=m Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme. causal interaction,unassigned 3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30426203&form=6&db=m The metalloprotease ADAMTS4 generates N-truncated A?4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30833305&form=6&db=m NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33556560&form=6&db=m Phenanthroline impairs ?APP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34117802&form=6&db=m MT5-MMP controls APP and ?-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer's disease. unassigned - 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34522714&form=6&db=m Sulfuretin exerts diversified functions in the processing of amyloid precursor protein. ongoing research,unassigned 2,0 3.4.24.77 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14966582&form=6&db=m [Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinase in ameloblastoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Amelogenesis Imperfecta http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393861&form=6&db=m Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype. ongoing research,unassigned 2,0 3.4.24.77 Amyloidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7579788&form=6&db=m The role of beta-amyloid in the development of Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130141&form=6&db=m Sjögren's syndrome initially presented as thrombotic thrombocytopenic purpura in a male patient: a case report and literature review. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30412131&form=6&db=m Relapsed/refractory acquired thrombotic thrombocytopenic purpura in a patient with Sjögren syndrome: Case report and review of the literature. causal interaction,unassigned 3,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590698&form=6&db=m A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient. unassigned - 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21657946&form=6&db=m Investigational drugs in thrombotic thrombocytopenic purpura. causal interaction,unassigned 1,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22265954&form=6&db=m Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637781&form=6&db=m What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28978852&form=6&db=m New developments in treatment modalities of thrombotic thrombocytopenic purpura. causal interaction,unassigned 3,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30235478&form=6&db=m Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab. causal interaction,unassigned 3,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31131442&form=6&db=m Utilizing a PLASMIC score-based approach in the management of suspected immune thrombotic thrombocytopenic purpura: a cost minimization analysis within the Harvard TMA Research Collaborative. causal interaction,unassigned 3,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31250841&form=6&db=m Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061729&form=6&db=m Assessment and Monitoring of Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): Strategies to Improve Outcomes. causal interaction,unassigned 3,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33842174&form=6&db=m Silent Thrombotic Thrombocytopenic Purpura: PLASMIC, Lessons Learned, and Current Management Overview. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527101&form=6&db=m Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient. causal interaction,unassigned 3,0 3.4.24.77 Anemia, Macrocytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20947535&form=6&db=m ADAMTS-13 deficiency: can it cause chronic renal failure? causal interaction,unassigned 4,0 3.4.24.77 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34267062&form=6&db=m Absence of exaggerated pharmacology by recombinant ADAMTS13 in the rat and monkey. causal interaction,unassigned 1,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1463662&form=6&db=m Characterization of an elastase from aneurysmal aorta which degrades intact aortic elastin. unassigned - 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7627707&form=6&db=m In situ localization and quantification of mRNA for 92-kD type IV collagenase and its inhibitor in aneurysmal, occlusive, and normal aorta. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9310982&form=6&db=m Matrix metalloproteinase-9 in cerebral aneurysms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006388&form=6&db=m Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo. causal interaction,unassigned 4,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414517&form=6&db=m Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12764279&form=6&db=m Paracrine secretion of transforming growth factor-beta1 in aneurysm healing and stabilization with endovascular smooth muscle cell therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636188&form=6&db=m Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16716358&form=6&db=m Early Increased MT1-MMP Expression and Late MMP-2 and MMP-9 Activity during Angiotensin II Induced Aneurysm Formation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16931892&form=6&db=m Apolipoprotein E Knockout Mice Over-Expressing Human Tissue Inhibitor of Metalloproteinase 1 Are Protected against Aneurysm Formation but Not against Atherosclerotic Plaque Development. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098543&form=6&db=m Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17494658&form=6&db=m mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays. ongoing research,therapeutic application,unassigned 2,4,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18971037&form=6&db=m Metalloproteinase expression in venous aneurysms. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20638679&form=6&db=m The Novel Function of Advanced Glycation End Products in Regulation of MMP-9 Production. causal interaction,unassigned 4,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23585675&form=6&db=m CD43-mediated IFN-? production by CD8+ T cells promotes abdominal aortic aneurysm in mice. unassigned - 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975840&form=6&db=m Concomitant coiling reduces metalloproteinase levels in flow diverter-treated aneurysms but anti-inflammatory treatment has no effect. therapeutic application,unassigned 4,0 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27624703&form=6&db=m A potential role for glycated cross-links in abdominal aortic aneurysm disease. unassigned - 3.4.24.77 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31213733&form=6&db=m Toward modeling the effects of regional material properties on the wall stress distribution of abdominal aortic aneurysms. unassigned - 3.4.24.77 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999533&form=6&db=m Decreased tissue inhibitor of metalloproteinase-2/matrix metalloproteinase ratio in the acute phase of aortic dissection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 3.4.24.77 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21728902&form=6&db=m A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.77 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24432723&form=6&db=m MMP-12 as a new marker of Stanford-A acute aortic dissection. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,3 3.4.24.77 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26563155&form=6&db=m A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Angina, Stable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17667031&form=6&db=m In-hospital outcome of patients with acute coronary syndrome: relationship with inflammation and remodeling markers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423320&form=6&db=m Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Anhedonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28241050&form=6&db=m Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Ankylosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18516314&form=6&db=m Update on the treatment of ankylosing spondylitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7854123&form=6&db=m Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. causal interaction,unassigned 3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718924&form=6&db=m The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. therapeutic application,unassigned 4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15276179&form=6&db=m Stop the killer: how to inhibit the anthrax lethal factor metalloprotease. unassigned - 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15983377&form=6&db=m Efficient synthetic inhibitors of anthrax lethal factor. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16386899&form=6&db=m Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors. therapeutic application,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16870442&form=6&db=m Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17339348&form=6&db=m Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin. diagnostic usage,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18276157&form=6&db=m Efficient production and characterization of Bacillus anthracis lethal factor and a novel inactive mutant rLFm-Y236F. causal interaction,unassigned 3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18289054&form=6&db=m Discovery and development of anthrax lethal factor metalloproteinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336349&form=6&db=m Low molecular weight inhibitors of the protease anthrax lethal factor. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18769623&form=6&db=m Role of N-terminal amino acids in the potency of anthrax lethal factor. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18831046&form=6&db=m Computational insights into the interaction of the anthrax lethal factor with the N-terminal region of its substrates. unassigned - 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19665472&form=6&db=m The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity. ongoing research,unassigned 3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19779559&form=6&db=m Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. ongoing research,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20155918&form=6&db=m Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors. diagnostic usage,therapeutic application,unassigned 2,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20438702&form=6&db=m Purification and Biophysical Characterization of the Core Protease Domain of Anthrax Lethal Factor. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20572812&form=6&db=m A novel pharmacophore model for the design of anthrax lethal factor inhibitors. ongoing research,therapeutic application,unassigned 2,3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20833809&form=6&db=m Residue histidine 669 is essential for the catalytic activity of Bacillus anthracis lethal factor. causal interaction,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21059339&form=6&db=m Alkaline earth metals are not required for the restoration of the apoform of anthrax lethal factor to its holoenzyme state. unassigned - 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21567315&form=6&db=m Ultrasensitive detection of botulinum neurotoxins and anthrax lethal factor in biological samples by ALISSA. therapeutic application,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22069624&form=6&db=m Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin. therapeutic application,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22189685&form=6&db=m Identification of a lead small-molecule inhibitor of anthrax lethal toxin by using fluorescence-based high-throughput screening. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22270239&form=6&db=m Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. therapeutic application,unassigned 2,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561400&form=6&db=m Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22747600&form=6&db=m Bacillus anthracis' Lethal Toxin Induces Broad Transcriptional Responses in Human Peripheral Monocytes. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22840775&form=6&db=m Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. therapeutic application,unassigned 4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22992735&form=6&db=m Certhrax toxin, an anthrax-related ADP-ribosyltransferase from Bacillus cereus. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23313942&form=6&db=m Effect of pH on the catalytic function and zinc content of native and immobilized anthrax lethal factor. ongoing research,unassigned 3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25042732&form=6&db=m High metal substitution tolerance of anthrax lethal factor and characterization of its active copper-substituted analogue. unassigned - 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25262802&form=6&db=m Anthrax lethal factor inhibitors as potential countermeasure of the infection. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25981534&form=6&db=m Effects of metalloprotease anthrax lethal factor on its peptide-based inhibitor R9LF-1. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26615468&form=6&db=m Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors. causal interaction,unassigned 2,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27035230&form=6&db=m Profiling lethal factor interacting proteins from human stomach using T7 phage display screening. therapeutic application,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27072692&form=6&db=m Inhibitors of the Metalloproteinase Anthrax Lethal Factor. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27909054&form=6&db=m Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30267305&form=6&db=m Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30872531&form=6&db=m N-terminal degradation activates the NLRP1B inflammasome. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31061172&form=6&db=m The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin. causal interaction,unassigned 1,0 3.4.24.77 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31268597&form=6&db=m The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin. causal interaction,unassigned 1,0 3.4.24.77 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664330&form=6&db=m The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2 3.4.24.77 Antiphospholipid Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33914240&form=6&db=m Double positivity of anti-?2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody. ongoing research,unassigned 1,0 3.4.24.77 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098543&form=6&db=m Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32289298&form=6&db=m Shear Stress and Aortic Strain Associations With Biomarkers of Ascending Thoracic Aortic Aneurysm. ongoing research,unassigned 2,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615801&form=6&db=m Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. unassigned - 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8049193&form=6&db=m Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. unassigned - 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9337194&form=6&db=m Size matters: the relationship between MMP-9 expression and aortic diameter. causal interaction,unassigned 1,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928630&form=6&db=m Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: complementary DNA expression profiling in the molecular characterization of aortic disease. unassigned - 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999533&form=6&db=m Decreased tissue inhibitor of metalloproteinase-2/matrix metalloproteinase ratio in the acute phase of aortic dissection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15652949&form=6&db=m Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288704&form=6&db=m Matrix metalloproteinases in the aneurysm wall of patients treated with low-dose doxycycline. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18025061&form=6&db=m Matrix metalloproteinase expression in the ascending aorta and aortic valve. ongoing research,unassigned 1,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18641692&form=6&db=m Pravastatin increases the expression of the tissue inhibitor of matrix metalloproteinase-1 and the oncogene Bax in human aortic abdominal aneurysms. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21039990&form=6&db=m Combining two potential causes of metalloproteinase secretion causes abdominal aortic aneurysms in rats: a new experimental model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21802713&form=6&db=m Homocysteine and metalloprotease-3 and -9 in patients with ascending Aorta Aneurysms. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22433495&form=6&db=m Expression of a disintegrin and metalloprotease in human abdominal aortic aneurysms. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947615&form=6&db=m Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/?-Aminopropionitrile-Induced Abdominal Aortic Aneurysm. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29499360&form=6&db=m Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32078829&form=6&db=m Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33206510&form=6&db=m Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17000289&form=6&db=m Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.77 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17382648&form=6&db=m Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 3.4.24.77 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20621845&form=6&db=m Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27156333&form=6&db=m The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087447&form=6&db=m Association of modifiers and other genetic factors explain Marfan syndrome clinical variability. unassigned - 3.4.24.77 Aortic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28067899&form=6&db=m Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Appendicitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28951011&form=6&db=m Biomarkers to estimate the probability of complicated appendicitis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.24.77 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22497081&form=6&db=m [Animal in vivo model of arrhythmia for genes target identification for 5-amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one]. unassigned - 3.4.24.77 Arteriovenous Fistula http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20881035&form=6&db=m {beta}-Catenin is Markedly Induced in a Murine Model of an Arteriovenous Fistula: The Effect of Metalloproteinase Inhibition. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Arteriovenous Fistula http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21620625&form=6&db=m Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Arteriovenous Malformations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796276&form=6&db=m The rs9509 polymorphism of MMP-9 is associated with risk of hemorrhage in brain arteriovenous malformations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.24.77 Arteriovenous Malformations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723034&form=6&db=m Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843867&form=6&db=m Elevated levels of 92-kd type IV collagenase (matrix metalloproteinase 9) in giant cell arteritis. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1433014&form=6&db=m Fibronectin fragments in osteoarthritic synovial fluid. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2687329&form=6&db=m Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7783051&form=6&db=m Activated gelatinase-B (MMP-9) and urokinase-type plasminogen activator in synovial fluids of patients with arthritis. Correlation with clinical and experimental variables of inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8003635&form=6&db=m Differential expression of the small inducible cytokines GRO alpha and GRO beta by synovial fibroblasts in chronic arthritis: possible role in growth regulation. causal interaction,unassigned 4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8342606&form=6&db=m Rabbit models of arthritis: immunolocalization of matrix metalloproteinases and tissue inhibitor of metalloproteinase in synovium and cartilage. ongoing research,unassigned 4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8431206&form=6&db=m Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8941646&form=6&db=m Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. causal interaction,unassigned 1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9550473&form=6&db=m Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. causal interaction,unassigned 2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9663476&form=6&db=m Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892501&form=6&db=m AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. unassigned - 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11234674&form=6&db=m [Gene transfer immunotherapy in rheumatoid arthritis: perspectives] causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301286&form=6&db=m TACE and other ADAM proteases as targets for drug discovery. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11435459&form=6&db=m c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11817044&form=6&db=m Separation and identification methods for metalloproteinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867212&form=6&db=m Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. causal interaction,unassigned 1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12180743&form=6&db=m Synovial membrane expression of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides. ongoing research,unassigned 4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12447632&form=6&db=m Changes in the concentration of plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) after total joint replacement in patients with arthritis. causal interaction,unassigned 3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12814616&form=6&db=m Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites. therapeutic application,unassigned 1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899037&form=6&db=m Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987500&form=6&db=m ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. causal interaction,unassigned 4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16406703&form=6&db=m ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16472131&form=6&db=m ADAMTS Proteinases: Potential Therapeutic Targets? causal interaction,unassigned 3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17559674&form=6&db=m Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17703334&form=6&db=m Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897672&form=6&db=m Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains. ongoing research,unassigned 1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18992360&form=6&db=m Characterization of proADAMTS5 processing by proprotein convertases. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250981&form=6&db=m Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. unassigned - 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19487464&form=6&db=m ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor. causal interaction,unassigned 3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737139&form=6&db=m Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8). ongoing research,unassigned 2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412686&form=6&db=m The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene. causal interaction,unassigned 3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20509880&form=6&db=m Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21365186&form=6&db=m The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21415364&form=6&db=m Cross-domain inhibition of TACE ectodomain. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21885500&form=6&db=m Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22005949&form=6&db=m Wnt signaling genes of murine chromosome 15 are involved in gender-affected pathways of inflammatory arthritis. causal interaction,unassigned 2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22065068&form=6&db=m Role of Sp1 transcription factor in Interleukin-1-induced ADAMTS-4 (aggrecanase-1) gene expression in human articular chondrocytes. unassigned - 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22676306&form=6&db=m The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22832115&form=6&db=m Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases. ongoing research,unassigned 4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922033&form=6&db=m Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome. diagnostic usage,unassigned 3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319426&form=6&db=m ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562508&form=6&db=m ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819400&form=6&db=m The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. causal interaction,unassigned 4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24876675&form=6&db=m ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24896365&form=6&db=m ADAMTS-18: a metalloproteinase with multiple functions. causal interaction,unassigned 4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25606593&form=6&db=m Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26135838&form=6&db=m Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26785775&form=6&db=m Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193842&form=6&db=m Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5. therapeutic application,unassigned 1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454584&form=6&db=m Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30406565&form=6&db=m Autoantibody and metalloproteinase activity in early arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450736&form=6&db=m Engineering of TIMP-3 as a LAP-fusion protein for targeting to sites of inflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826330&form=6&db=m Inhibition of MMPs and ADAM/ADAMTS. unassigned - 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410713&form=6&db=m Targeting a cysteine protease from a pathobiont alleviates experimental arthritis. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32772139&form=6&db=m Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. causal interaction,unassigned 3,0 3.4.24.77 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33778274&form=6&db=m Feprazone Ameliorates TNF-?-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS-5 Signaling Pathway. causal interaction,unassigned 3,0 3.4.24.77 Arthritis, Gouty http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12858344&form=6&db=m Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Arthritis, Juvenile http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17703334&form=6&db=m Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.24.77 Arthritis, Psoriatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15229943&form=6&db=m Quantitation of metalloproteinase gene expression in rheumatoid and psoriatic arthritis synovial tissue distal and proximal to the cartilage-pannus junction. ongoing research,unassigned 3,0 3.4.24.77 Arthritis, Reactive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8192476&form=6&db=m Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=666744&form=6&db=m Degradation of cartilage proteoglycans by a neutral proteinase secreted by rabbit bone-marrow macrophages in culture. causal interaction,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1456176&form=6&db=m A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901643&form=6&db=m Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1. causal interaction,unassigned 3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2605216&form=6&db=m Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts. ongoing research,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040994&form=6&db=m Regulation of collagenase gene expression in synovial cells. causal interaction,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7732485&form=6&db=m [Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8015285&form=6&db=m Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8304246&form=6&db=m Inhibition of metalloproteinase activity of rheumatoid arthritis synovial cells by a new inhibitor [BE16627B; L-N-(N-hydroxy-2-isobutylsuccinamoyl)-seryl-L-valine] causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8639190&form=6&db=m Serum pro-matrix metalloproteinase 3 in rheumatoid arthritis: a reflection of local or systemic inflammation? diagnostic usage,unassigned 1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049977&form=6&db=m Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells. ongoing research,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9122163&form=6&db=m Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9542779&form=6&db=m TNF-alpha induces the transcription factor Egr-1, pro-inflammatory cytokines and cell proliferation in human skin fibroblasts and synovial lining cells. causal interaction,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918237&form=6&db=m Matrix metalloproteinases, tissue inhibitors of metalloproteinases, and glycosaminoglycans in synovial fluid from patients with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9973441&form=6&db=m Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403281&form=6&db=m Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10817568&form=6&db=m Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. ongoing research,unassigned 3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10936503&form=6&db=m 4'-Hydroxy aceclofenac suppresses the interleukin-1-induced production of promatrix metalloproteinases and release of sulfated-glycosaminoglycans from rabbit articular chondrocytes. therapeutic application,unassigned 1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10943872&form=6&db=m Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11060752&form=6&db=m Metalloproteinase inhibitors: new opportunities for the treatment of rheumatoid arthritis and osteoarthritis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11096152&form=6&db=m Circulating levels of matrix metalloproteinases MMP-3 and MMP-2 in renal transplant recipients with chronic transplant nephropathy. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11248661&form=6&db=m Messenger-RNA expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and transcription factors in rheumatic synovial cells under mechanical stimuli. unassigned - 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592366&form=6&db=m Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11817610&form=6&db=m Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966774&form=6&db=m Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. ongoing research,unassigned 2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124858&form=6&db=m Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms: Association with severity and progression of rheumatoid arthritis in a prospective study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12428226&form=6&db=m Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. causal interaction,unassigned 3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13130493&form=6&db=m Polymorphism in the stromelysin 1 (matrix metalloproteinase 3) promoter gene and severity of rheumatoid arthritis: comment on the article by Constantin et al. ongoing research,unassigned 2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14579524&form=6&db=m Design strategies for the identification of MMP-13 and Tace inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718605&form=6&db=m Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis. therapeutic application,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161923&form=6&db=m ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. unassigned - 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15320727&form=6&db=m The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE. therapeutic application,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476203&form=6&db=m Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485996&form=6&db=m Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16298911&form=6&db=m Biomarkers for diagnosing and monitoring autoimmune diseases. ongoing research,unassigned 1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17393389&form=6&db=m LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes. unassigned - 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17546624&form=6&db=m Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18397961&form=6&db=m Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. ongoing research,unassigned 2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18541144&form=6&db=m Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice. causal interaction,unassigned 2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19078187&form=6&db=m Effect of Tenidap on Metalloproteinase Gene Expression in Rheumatoid Arthritis: A Synovial Biopsy Study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098927&form=6&db=m The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456279&form=6&db=m Selective MMP-12 inhibitors: WO-2008057254. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19765281&form=6&db=m Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20516019&form=6&db=m ADAMTS5 is a biomarker for prediction of response to infliximab in patients with rheumatoid arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20871631&form=6&db=m A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21913037&form=6&db=m Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation of pro-matrix metalloproteinase (MMP)-13. ongoing research,unassigned 3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22146575&form=6&db=m A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release. unassigned - 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22342143&form=6&db=m Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22823240&form=6&db=m Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028451&form=6&db=m Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23918525&form=6&db=m ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24361716&form=6&db=m Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition. unassigned - 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24646716&form=6&db=m Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury. causal interaction,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819400&form=6&db=m The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. causal interaction,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25045124&form=6&db=m Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes. causal interaction,unassigned 4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27846745&form=6&db=m A disintegrin and metalloproteinase (ADAM)-10 as a predictive factor for tocilizumab effectiveness in rheumatoid arthritis. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30187662&form=6&db=m Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis - results from the CHIKARA study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30634456&form=6&db=m A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31250758&form=6&db=m The oral administration effect of drug mannuronic acid (M2000) on gene expression of matrix and tissue inhibitor of metalloproteinases in rheumatoid arthritis patients. ongoing research,therapeutic application,unassigned 1,3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31369701&form=6&db=m Novel functions of inactive rhomboid proteins in immunity and disease. causal interaction,unassigned 3,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34121372&form=6&db=m Serum Metalloprotease 3 (MMP-3) biomarker of therapeutic efficacy during treatment of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364500&form=6&db=m Simultaneous determination of CXCL7 chemokine and MMP3 metalloproteinase as biomarkers for rheumatoid arthritis. diagnostic usage,unassigned 2,0 3.4.24.77 Arthrogryposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26951213&form=6&db=m ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis. therapeutic application,unassigned 1,0 3.4.24.77 Arthrogryposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29132416&form=6&db=m Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders. unassigned - 3.4.24.77 Aspergillosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7927676&form=6&db=m Molecular cloning and sequencing of the cDNA and gene for a novel elastinolytic metalloproteinase from Aspergillus fumigatus and its expression in Escherichia coli. ongoing research,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12534559&form=6&db=m Metalloproteinase-9 is increased after toluene diisocyanate exposure in the induced sputum from patients with toluene diisocyanate-induced asthma. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12885268&form=6&db=m ADAM33: a novel therapeutic target for asthma. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14564349&form=6&db=m Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14659745&form=6&db=m Crystal structure of the catalytic domain of human ADAM33. unassigned - 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087305&form=6&db=m Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15208587&form=6&db=m ADAM33 polymorphisms and phenotype associations in childhood asthma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298558&form=6&db=m Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555945&form=6&db=m Protease domain of human ADAM33 produced by Drosophila S2 cells. causal interaction,unassigned 2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15806035&form=6&db=m Diversity of asthma: evolving concepts of pathophysiology and lessons from genetics. unassigned - 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863647&form=6&db=m Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879414&form=6&db=m A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15986064&form=6&db=m Asthma severity and genetics in Taiwan. unassigned - 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16387804&form=6&db=m A disintegrin and metalloproteinase 33 protein in patients with asthma: Relevance to airflow limitation. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522446&form=6&db=m Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16650044&form=6&db=m ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16784537&form=6&db=m The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16799089&form=6&db=m The genetics of asthma: ADAM33 as an example of a susceptibility gene. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16873001&form=6&db=m Genetic aspects of the etiology and treatment of asthma. diagnostic usage,unassigned 1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890764&form=6&db=m Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci. causal interaction,unassigned 2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943435&form=6&db=m ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. causal interaction,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17208589&form=6&db=m Downregulation of a disintegrin and metalloproteinase 33 by IFN-gamma in human airway smooth muscle cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17339047&form=6&db=m Increased expression of ADAM33 and ADAM8 with disease progression in asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17400878&form=6&db=m Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms. causal interaction,unassigned 4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403951&form=6&db=m DNA sequence variations of metalloproteinases: their role in asthma and COPD. causal interaction,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410963&form=6&db=m The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18423563&form=6&db=m Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells. causal interaction,unassigned 4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18778489&form=6&db=m Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19146844&form=6&db=m ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19317339&form=6&db=m Association between ADAM33 polymorphisms and asthma in a Thai population. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19361849&form=6&db=m The outer wall of small airways is a major site of remodeling in fatal asthma. ongoing research,unassigned 4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19373511&form=6&db=m Upregulation of ADAM8 in the Airways of Mice with Allergic Bronchial Asthma. causal interaction,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19397475&form=6&db=m ADAM8: a new therapeutic target for asthma. causal interaction,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456279&form=6&db=m Selective MMP-12 inhibitors: WO-2008057254. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19522858&form=6&db=m Platelet-derived growth factor and transforming growth factor-beta modulate the expression of matrix metalloproteinases and migratory function of human airway smooth muscle cells. causal interaction,unassigned 4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625177&form=6&db=m Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. causal interaction,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19635592&form=6&db=m The effects of Th2 cytokines on the expression of ADAM33 in allergen-induced chronic airway inflammation. causal interaction,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19665773&form=6&db=m Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725580&form=6&db=m Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20003279&form=6&db=m Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,3 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20008875&form=6&db=m The role of the epithelium in airway remodeling in asthma. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20194813&form=6&db=m The Metalloprotease-disintegrin ADAM8 is Essential for the Development of Experimental Asthma. causal interaction,unassigned 4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20309924&form=6&db=m Genetics and asthma disease susceptibility in the US Latino population. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20513247&form=6&db=m Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. causal interaction,unassigned 4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697605&form=6&db=m ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20868478&form=6&db=m Asthma susceptible genes in Chinese population: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689380&form=6&db=m Association of ADAM33 gene polymorphisms with asthma in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21930123&form=6&db=m Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population. causal interaction,unassigned 1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22035178&form=6&db=m ADAM33 gene polymorphisms associate with asthma susceptibility and severity in East China han population. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22583515&form=6&db=m ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22712283&form=6&db=m [The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases]. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22851202&form=6&db=m Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23257708&form=6&db=m The Methylation Patterns of a Disintegrin and Metalloproteinase 33 Gene (ADAM33) in Adult Asthma. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23380143&form=6&db=m A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23612257&form=6&db=m Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23934418&form=6&db=m ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24035932&form=6&db=m Frequency of genetic polymorphisms of ADAM33 and their association with allergic rhinitis among Jordanians. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24179679&form=6&db=m Mechanisms of asthma and implications for its prevention and treatment: a personal journey. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24498518&form=6&db=m Association of matrix metalloproteinase 8 genetic polymorphisms with bronchial asthma in a Japanese population. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24646716&form=6&db=m Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury. causal interaction,unassigned 4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24648966&form=6&db=m Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24817794&form=6&db=m ADAM metallopeptidase domain 33 (ADAM33): a promising target for asthma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25036518&form=6&db=m Association between polymorphisms in ADAM33, CD14, and TLR4 with asthma in the Uygur population in China. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25068505&form=6&db=m Association between genetic polymorphisms in the ADAM33 gene and asthma risk: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25154990&form=6&db=m [Relationship between disintegrin and metalloproteinase gene polymorphism of bronchial asthma and its severity in Uygur population]. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25279200&form=6&db=m Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25299150&form=6&db=m Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island population. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25313536&form=6&db=m Association between ADAM33 polymorphisms and susceptibility with adult and childhood asthma among Jordanians. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25730038&form=6&db=m Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26291893&form=6&db=m The ADAM33 S2 Polymorphism Is Associated with Susceptibility to Pediatric Asthma in the Chinese Han Population. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26496719&form=6&db=m Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model. therapeutic application,unassigned 3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26666372&form=6&db=m Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27090654&form=6&db=m Evaluation of Pregnancy-Associated Plasma Protein-A Levels in Patients with Chronic Obstructive Pulmonary Disease and Associations with Disease Severity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27458083&form=6&db=m A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27489884&form=6&db=m Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27579513&form=6&db=m Upregulation of a disintegrin and metalloproteinase-33 by VEGF in human airway smooth muscle cells: Implications for asthma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720670&form=6&db=m Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799384&form=6&db=m Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056993&form=6&db=m Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28285393&form=6&db=m T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28378503&form=6&db=m IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration. unassigned - 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429897&form=6&db=m Single nucleotide polymorphisms V4 and T1 of the ADAM33 gene in Venezuelan patients with asthma or chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28451394&form=6&db=m ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29149777&form=6&db=m Investigating the Association of ADAM33 Single Nucleotide Polymorphisms (SNPs) with Susceptibility to Allergic Asthma in Azerbaijan Population of Iran: A Case-control Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399106&form=6&db=m TGF-?1 stimulates epithelial-mesenchymal transition mediated by ADAM33. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30160137&form=6&db=m ADAM 33 gene V4 C/G rs2787094 polymorphism in psoriasis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450713&form=6&db=m Silencing of ADAM33 restrains proliferation and induces apoptosis of airway smooth muscle cells in ovalbumin-induced asthma model. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591802&form=6&db=m Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30791911&form=6&db=m Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31626088&form=6&db=m Genetic association of ADAM33 polymorphisms with childhood asthma in Chinese Han population: A case-control study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32185952&form=6&db=m Effect of Xiaochuanping powder on the inflammatory response and airway remodeling in asthmatic rats. therapeutic application,unassigned 1,0 3.4.24.77 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32376513&form=6&db=m Endothelial dysfunction and pentraxin-3 in clinically stable adult asthma patients. diagnostic usage,unassigned 3,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8558175&form=6&db=m Transfection of an invasive human astrocytoma cell line with a TIMP-1 cDNA: modulation of astrocytoma invasive potential. ongoing research,unassigned 1,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943093&form=6&db=m Expression of stromelysin 1 in human astrocytoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9322849&form=6&db=m Implantation of C6 astrocytoma spheroid into collagen type I gels: invasive, proliferative, and enzymatic characterizations. therapeutic application,unassigned 1,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9426071&form=6&db=m Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060611&form=6&db=m Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866026&form=6&db=m Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16829558&form=6&db=m The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors. ongoing research,unassigned 1,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18563800&form=6&db=m Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19220854&form=6&db=m The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804825&form=6&db=m Thromboxane A(2) receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-delta and PKC-varepsilon in the shedding of epidermal growth factor receptor ligands. unassigned - 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556615&form=6&db=m Expression of timp-1, timp-2, 72-kda and 92-kda type-iv collagenase transcripts in human astrocytoma cell-lines - correlation with astrocytoma cell invasiveness. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713642&form=6&db=m Differential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8608454&form=6&db=m Induction of tissue inhibitor of metalloproteinase and its mitogenic response to endothelial cells in human atherosclerotic and restenotic lesions. ongoing research,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049977&form=6&db=m Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells. ongoing research,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9422537&form=6&db=m Interactions of monocytic cells with human endothelial cells stimulate monocytic metalloproteinase production. unassigned - 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12028873&form=6&db=m Stimulated release of endothelin-converting enzyme is simultaneous with tissue-type plasminogen activator and decrease in coronary heart disease. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534304&form=6&db=m Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. causal interaction,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15530896&form=6&db=m Chlamydia pneumoniae (C. pneumoniae) infection upregulates atherosclerosis-related gene expression in human umbilical vein endothelial cells (HUVECs). unassigned - 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539621&form=6&db=m Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16029145&form=6&db=m New trends in anti-atherosclerotic agents. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636188&form=6&db=m Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17157395&form=6&db=m Pregnancy-associated plasma protein-A: an emerging cardiac biomarker. causal interaction,unassigned 1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18582628&form=6&db=m Radionuclide imaging: a molecular key to the atherosclerotic plaque. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18801353&form=6&db=m Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19339995&form=6&db=m Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456279&form=6&db=m Selective MMP-12 inhibitors: WO-2008057254. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19662466&form=6&db=m Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804138&form=6&db=m Molecular imaging of vulnerable atherosclerotic plaques. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19943213&form=6&db=m Coronary Artery Disease - Eighth International Congress. From prevention to intervention. therapeutic application,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20434371&form=6&db=m Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20538289&form=6&db=m Celecoxib combined with atorvastatin prevents progression of atherosclerosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20687985&form=6&db=m [Association of gamma glutamyltransferase, metabolic syndrome and cardiovascular risk] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814017&form=6&db=m A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. causal interaction,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21334453&form=6&db=m The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-? and requires Smads, p38 mitogen-activated protein kinase and c-Jun. causal interaction,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946608&form=6&db=m Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21984580&form=6&db=m Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22015660&form=6&db=m Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228717&form=6&db=m TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22572488&form=6&db=m Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23642811&form=6&db=m Functional blockage of EMMPRIN ameliorates atherosclerosis in apolipoprotein E-deficient mice. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688016&form=6&db=m Leptin and Vascular Smooth Muscle Cells. causal interaction,unassigned 3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595230&form=6&db=m Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24871629&form=6&db=m Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1? causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24876675&form=6&db=m ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24896365&form=6&db=m ADAMTS-18: a metalloproteinase with multiple functions. causal interaction,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25712207&form=6&db=m ADAMTS7 in Cardiovascular Disease: From Bedside to Bench and Back Again? causal interaction,unassigned 3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25883421&form=6&db=m Pregnancy Associated Plasma Protein-A (PAPP-A) Levels in Acute Coronary Syndrome: A Case Control Study in a Tertiary Care Centre. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26500845&form=6&db=m TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice. unassigned - 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26563155&form=6&db=m A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26589205&form=6&db=m Evaluation of Cardiovascular Changes in Children with BAVs. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26645981&form=6&db=m Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27844209&form=6&db=m The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28205274&form=6&db=m Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease. causal interaction,unassigned 1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454584&form=6&db=m Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849199&form=6&db=m Upregulation of ADAMTS?7 and downregulation of COMP are associated with aortic aneurysm. causal interaction,unassigned 3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28937860&form=6&db=m Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29326312&form=6&db=m FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13). causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348121&form=6&db=m Endothelial Cell-Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29622563&form=6&db=m Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29980058&form=6&db=m Association of serum ADAMTS7 levels and genetic variant rs1994016 with acute coronary syndrome in a Chinese population: A case control study. causal interaction,unassigned 1,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181741&form=6&db=m Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30254012&form=6&db=m Electronegative LDL induces MMP-9 and TIMP-1 release in monocytes through CD14 activation: Inhibitory effect of glycosaminoglycan sulodexide. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30347750&form=6&db=m Non-Invasive Detection of Extracellular Matrix Metalloproteinase Inducer EMMPRIN, a New Therapeutic Target against Atherosclerosis, Inhibited by Endothelial Nitric Oxide. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30583923&form=6&db=m IL-1?/MMP9 activation in primary human vascular smooth muscle-like cells: Exploring the role of TNF? and P2X7. unassigned - 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185010&form=6&db=m ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32829217&form=6&db=m Von Willebrand Factor and ADAMTS13 and long-term outcomes in patients undergoing percutaneous coronary intervention. causal interaction,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33307720&form=6&db=m Association Between Plasma ADAMTS-9 Levels and Severity of Coronary Artery Disease. causal interaction,unassigned 4,0 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33508770&form=6&db=m Suppression of PAPP-A mitigates atherosclerosis by mediating macrophage polarization via STAT3 signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33761760&form=6&db=m Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15808077&form=6&db=m [Effects of matrix metalloproteinase-9 and tissue inhibitor-1 of metalloproteinase expression on atrial structural remodeling during chronic atrial fibrillation] causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17655664&form=6&db=m Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation. causal interaction,unassigned 2,0 3.4.24.77 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18260972&form=6&db=m [Metalloproteinase activity of the blood in patients with arterial hypertension with paroxysmal form of atrial fibrillation.] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.4.24.77 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18823968&form=6&db=m Brain natriuretic peptide correlates with the extent of atrial fibrillation-associated silent brain lesions. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501421&form=6&db=m [Role of matrix metalloproteinase and tissue inhibitor of metalloproteinase in atrial structural remodeling in patients with atrial fibrillation] causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25971370&form=6&db=m TGF-?1 and TIMP-4 regulate atrial fibrosis in atrial fibrillation secondary to rheumatic heart disease. ongoing research,unassigned 1,0 3.4.24.77 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28266892&form=6&db=m Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis. therapeutic application,unassigned 1,0 3.4.24.77 Atypical Hemolytic Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22879435&form=6&db=m Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Atypical Hemolytic Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26276936&form=6&db=m Thrombosis, Microangiopathies, and Inflammation. causal interaction,unassigned 4,0 3.4.24.77 Atypical Hemolytic Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911616&form=6&db=m Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Atypical Hemolytic Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30524124&form=6&db=m Deficiency of complement factor H-related proteins and autoantibody-positive hemolytic uremic syndrome in an infant with combined partial deficiencies and autoantibodies to complement factor H and ADAMTS13. causal interaction,unassigned 4,0 3.4.24.77 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8946145&form=6&db=m Flow cytometric analysis of gelatinase B (MMP-9) activity using immobilized fluorescent substrate on microspheres. unassigned - 3.4.24.77 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15387437&form=6&db=m Changes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the serum of patients with autoimmune diseases: association with age and disease activity. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23410558&form=6&db=m Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25171914&form=6&db=m ADAM17 at the interface between inflammation and autoimmunity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31369701&form=6&db=m Novel functions of inactive rhomboid proteins in immunity and disease. causal interaction,unassigned 3,0 3.4.24.77 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34324950&form=6&db=m Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target? causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29737873&form=6&db=m ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9524071&form=6&db=m Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11743122&form=6&db=m The matrix metalloproteinase gene GmMMP2 is activated in response to pathogenic infections in soybean. therapeutic application,unassigned 1,0 3.4.24.77 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22091998&form=6&db=m Oxidation of Met1606 in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure. causal interaction,unassigned 1,0 3.4.24.77 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22831170&form=6&db=m Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23228665&form=6&db=m Solution structure and dynamics of C-terminal regulatory domain of Vibrio vulnificus extracellular metalloprotease. causal interaction,unassigned 2,0 3.4.24.77 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33333173&form=6&db=m Cellular and molecular modification of egg envelope hardening in fertilization. causal interaction,unassigned 1,0 3.4.24.77 Behcet Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842516&form=6&db=m The determination of matrix metalloproteinase 9 activity and gene expression levels in Behcet's disease patients with aneurysmal complications. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Bicuspid Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17382648&form=6&db=m Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 3.4.24.77 Bicuspid Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21070736&form=6&db=m Metalloproteinase polymorphisms and bicuspid aortic valves. causal interaction,diagnostic usage,unassigned 2,2,0 3.4.24.77 Bicuspid Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24774498&form=6&db=m Metalloproteinase polymorphisms and bicuspid aortic valves. causal interaction,diagnostic usage,unassigned 2,2,0 3.4.24.77 Bicuspid Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366218&form=6&db=m Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies. ongoing research,unassigned 1,0 3.4.24.77 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8611434&form=6&db=m Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9797720&form=6&db=m Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. unassigned - 3.4.24.77 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11710917&form=6&db=m Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20356362&form=6&db=m Matrix- metalloproteinase -2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20874665&form=6&db=m Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model. therapeutic application,unassigned 1,0 3.4.24.77 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32511239&form=6&db=m The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1422955&form=6&db=m An active neutral metalloproteinase bound to the insoluble collagen in the mineralized phase matrix of adult rat calvaria. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1585828&form=6&db=m Inhibition of bone resorption in vitro by human enkephalinase (EC 3.4.24.11), a neutral metalloendopeptidase. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7532319&form=6&db=m Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis. ongoing research,unassigned 3,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8147268&form=6&db=m Effect of tetracyclines which have metalloproteinase inhibitory capacity on basal and heparin-stimulated bone resorption by chick osteoclasts. therapeutic application,unassigned 1,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8275936&form=6&db=m Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis. ongoing research,unassigned 3,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8579123&form=6&db=m Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484362&form=6&db=m Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts. ongoing research,unassigned 2,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10620064&form=6&db=m Zoledronate is a potent inhibitor of myeloma cell growth and secretion of IL-6 and MMP-1 by the tumoral environment. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644538&form=6&db=m Long-term effects of infliximab on bone and cartilage turnover markers in patients with rheumatoid arthritis. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514432&form=6&db=m Expression profile of matrix metalloproteinase-2 and -9 and their endogenous tissue inhibitors in osteonecrotic femoral heads. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22718592&form=6&db=m Osteogenic capacity of transgenic flax scaffolds. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26538900&form=6&db=m Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26926023&form=6&db=m Effects of angiotensin II type I receptor blocker losartan on orthodontic tooth movement. unassigned - 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155621&form=6&db=m Fibroblasts and Osteoblasts in Inflammation and Bone Damage. causal interaction,unassigned 4,0 3.4.24.77 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30615802&form=6&db=m The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Border Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25799514&form=6&db=m Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in Border disease virus-infected small ruminants. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Botulism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8542757&form=6&db=m Intracellular targets and metalloprotease activity of tetanus and botulism neurotoxins. ongoing research,unassigned 1,0 3.4.24.77 Botulism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20959871&form=6&db=m Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Botulism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21116458&form=6&db=m Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease. diagnostic usage,unassigned 3,0 3.4.24.77 Botulism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22516424&form=6&db=m The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.77 Botulism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314875&form=6&db=m High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. unassigned - 3.4.24.77 Botulism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31771110&form=6&db=m Tables of Toxicity of Botulinum and Tetanus Neurotoxins. causal interaction,unassigned 2,0 3.4.24.77 Brachydactyly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201140&form=6&db=m Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage. unassigned - 3.4.24.77 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8110987&form=6&db=m Effects of tricyclic compounds on membrane binding of bivalent cations, activities of acetylcholinesterase and some tissue proteases. therapeutic application,unassigned 4,0 3.4.24.77 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28284900&form=6&db=m Crosstalk between glia, extracellular matrix and neurons. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17854901&form=6&db=m Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. causal interaction,unassigned 1,0 3.4.24.77 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17904058&form=6&db=m Expression of matrix metalloproteinse-9 in thrombin-induced brain edema formation in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.4.24.77 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066093&form=6&db=m Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood-brain barrier integrity in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.4.24.77 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29789393&form=6&db=m Long-Term Outcomes in Patients Aged ?70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis. diagnostic usage,unassigned 3,0 3.4.24.77 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17509227&form=6&db=m Effects of tissue plasminogen activator on cerebral microvessels of rats during focal cerebral ischemia and reperfusion. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206824&form=6&db=m Time dependent integration of matrix metalloproteinases and their targeted substrates directs axonal sprouting and synaptogenesis following central nervous system injury. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28284900&form=6&db=m Crosstalk between glia, extracellular matrix and neurons. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24441327&form=6&db=m Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with moderate and severe traumatic brain injury. ongoing research,unassigned 4,0 3.4.24.77 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29576714&form=6&db=m Rhubarb attenuates cerebral edema via inhibition of the extracellular signal-regulated kinase pathway following traumatic brain injury in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2 3.4.24.77 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29848170&form=6&db=m Relative Deficiency of Plasma A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeats 13 Activity and Elevation of Human Neutrophil Peptides in Patients with Traumatic Brain Injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14736853&form=6&db=m Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17360688&form=6&db=m Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.77 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950707&form=6&db=m Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain. therapeutic application,unassigned 1,0 3.4.24.77 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20725136&form=6&db=m Endothelin-1-mediated cerebrovascular remodeling is not associated with increased ischemic brain injury in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21551278&form=6&db=m Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.77 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960133&form=6&db=m Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702312&form=6&db=m Role of HIF-1?-activated Epac1 on HSC-mediated neuroplasticity in stroke model. unassigned - 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8485704&form=6&db=m Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824624&form=6&db=m Comparative analysis of matrix metalloproteinases by immunocytochemistry, immunohistochemistry and zymography in human primary brain tumours. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10625689&form=6&db=m Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor. ongoing research,unassigned 3,0 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706098&form=6&db=m Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654977&form=6&db=m Promoter methylation status of multiple genes in brain metastases of solid tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15113477&form=6&db=m Inhibition of glioma angiogenesis and invasion by SI-27, an anti-matrix metalloproteinase agent in a rat brain tumor model. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16772875&form=6&db=m Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22841667&form=6&db=m A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32622867&form=6&db=m From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1701851&form=6&db=m A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7734294&form=6&db=m Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7880721&form=6&db=m Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts. ongoing research,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8174111&form=6&db=m Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207000&form=6&db=m Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8370623&form=6&db=m Metalloproteinase and TIMP expression by the human breast carcinoma cell line 8701-BC. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8608981&form=6&db=m Enhanced RNA expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in human breast cancer. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8766524&form=6&db=m Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8939999&form=6&db=m Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. ongoing research,unassigned 3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9014756&form=6&db=m Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9040946&form=6&db=m Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9190892&form=6&db=m Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9354769&form=6&db=m Expression of matrix metalloprotease-9 in vascular pericytes in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766680&form=6&db=m Selective localization of matrix metalloproteinase 9, beta1 integrins, and human lymphocyte antigen class I molecules on membrane vesicles shed by 8701-BC breast carcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872598&form=6&db=m Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases. unassigned - 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10445422&form=6&db=m Tissue inhibitor of metalloprotease (TIMP)-1 and proliferative behaviour of clonal breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485497&form=6&db=m Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. causal interaction,unassigned 3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571077&form=6&db=m Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10809781&form=6&db=m Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells. unassigned - 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11076665&form=6&db=m Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11288958&form=6&db=m Prognostic significance of the combined expression of matrix metalloproteinase-9, urokinase type plasminogen activator and its receptor in breast cancer as measured by Northern blot analysis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11406546&form=6&db=m Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11447735&form=6&db=m Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585740&form=6&db=m Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11727959&form=6&db=m Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11839648&form=6&db=m NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. diagnostic usage,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12142386&form=6&db=m Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12634613&form=6&db=m Interaction of 5-aza-2'-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12828172&form=6&db=m [Relationship between tissue inhibitors of metalloproteinase and metastasis and prognosis in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12874388&form=6&db=m Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14629269&form=6&db=m The favorable prognostic impact of tissue inhibitor of matrix metalloproteinases-1 protein overexpression in breast cancer cells. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14661055&form=6&db=m Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors. unassigned - 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744781&form=6&db=m Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15095266&form=6&db=m Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930294&form=6&db=m A role for ADAM12 in breast tumor progression and stromal cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15953625&form=6&db=m Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16088233&form=6&db=m Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16152618&form=6&db=m ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16168111&form=6&db=m Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170669&form=6&db=m Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213489&form=6&db=m ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16862147&form=6&db=m The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949931&form=6&db=m Low serum level of pro-matrix metalloproteinase 2 correlates with aggressive behavior in breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17189408&form=6&db=m Molecular profiling of ADAM12 in human bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897439&form=6&db=m Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18286531&form=6&db=m Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. ongoing research,unassigned 3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18394187&form=6&db=m Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413742&form=6&db=m Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18434311&form=6&db=m The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18505826&form=6&db=m Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19035119&form=6&db=m [Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19645775&form=6&db=m Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19647994&form=6&db=m Tissue inhibitor metalloproteinase type-1 (TIMP-1), a novel cancer biomarker predicting response of adjuvant anthracycline-based chemotherapy in patients afflicted with primary breast cancer. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794969&form=6&db=m Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843640&form=6&db=m Abl Interactor 1 Regulates Src-Id1-Matrix Metalloproteinase 9 Axis and Is Required for Invadopodia Formation, Extracellular Matrix Degradation, and Tumor Growth of Human Breast Cancer Cells. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19860811&form=6&db=m Alcohol Stimulates Activation of Snail, Epidermal Growth Factor Receptor Signaling, and Biomarkers of Epithelial-Mesenchymal Transition in Colon and Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20184770&form=6&db=m SplicerAV: a tool for mining microarray expression data for changes in RNA processing. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236691&form=6&db=m Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346171&form=6&db=m MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736367&form=6&db=m Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20835647&form=6&db=m The interaction between aromatase, metalloproteinase 2,9 and cd44 in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21147512&form=6&db=m Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21670150&form=6&db=m Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21769958&form=6&db=m Elevated NRD1 metalloprotease expression plays a role in breast cancer growth and proliferation. causal interaction,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016393&form=6&db=m Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1). causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160637&form=6&db=m TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22645147&form=6&db=m The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression. causal interaction,unassigned 2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22996753&form=6&db=m Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762791&form=6&db=m Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851508&form=6&db=m The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936642&form=6&db=m Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23975422&form=6&db=m IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24007880&form=6&db=m Src Plays a Key Role in ADAM28 Expression in v-src-Transformed Epithelial Cells and Human Carcinoma Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24256593&form=6&db=m [The correlation of synuclein-? and matrix metalloproteinase 9 in breast cancer]. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24344010&form=6&db=m The prognostic role of interleukin-8 (IL-8) and matrix metalloproteinases -2 and -9 in lymph node-negative untreated breast cancer patients. diagnostic usage,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24457941&form=6&db=m Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24633350&form=6&db=m 5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells. ongoing research,unassigned 3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819550&form=6&db=m The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25099234&form=6&db=m Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25336660&form=6&db=m N-glycosylation regulates ADAM8 processing and activation. ongoing research,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25370353&form=6&db=m Thalidomide combined with irradiation alters the activity of two proteases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25527274&form=6&db=m Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25656607&form=6&db=m Prognostic impact of polymorphism of matrix metalloproteinase-2 and metalloproteinase tissue inhibitor-2 promoters in breast cancer in Tunisia: case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25816670&form=6&db=m [Associating of polymorphism in the promoter regions of genes of metalloproteinase (MMP2, MMP3, MMP9) with options of the clinical course of breast cancer in Russian women]. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25893299&form=6&db=m p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26114632&form=6&db=m The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation. causal interaction,unassigned 1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26140253&form=6&db=m A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261534&form=6&db=m MiR-126 regulated breast cancer cell invasion by targeting ADAM9. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26488158&form=6&db=m Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis. ongoing research,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26663028&form=6&db=m Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26918856&form=6&db=m ADAM28 is expressed by epithelial cells in human normal tissues And protects from C1q-induced cell death. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26979595&form=6&db=m Expression and characterization of tissue inhibitor of metalloproteinase 4 from complex canine mammary carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277077&form=6&db=m Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27351228&form=6&db=m Characterization of a P-Rex1 gene signature in breast cancer cells. causal interaction,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27430992&form=6&db=m Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28093334&form=6&db=m In vitro antitumor and antiangiogenic effects of Bothropoidin, a metalloproteinase from Bothrops pauloensis snake venom. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28124276&form=6&db=m Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351385&form=6&db=m Erratum to: Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13. therapeutic application,unassigned 1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423710&form=6&db=m Phospholipase C?1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/?- catenin/MMP7 signalling. causal interaction,unassigned 3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28816390&form=6&db=m Differential expression and androgen regulation of microRNAs and metalloprotease 13 in breast cancer cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032615&form=6&db=m Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29085477&form=6&db=m Inhibition of cell invasion and migration by CEACAM1-4S in breast cancer. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29193730&form=6&db=m The 3p14.2 tumour suppressor ADAMTS9 is inactivated by promoter CpG methylation and inhibits tumour cell growth in breast cancer. unassigned - 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29212212&form=6&db=m ADAMTS1-mediated targeting of TSP-1 by PPAR? suppresses migration and invasion of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30080411&form=6&db=m Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor ?B-Matrix Metalloproteinase Signaling. unassigned - 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30226539&form=6&db=m Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine?disrupting chemicals. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30482778&form=6&db=m Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30792164&form=6&db=m MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30815959&form=6&db=m A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076513&form=6&db=m DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes. diagnostic usage,unassigned 1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31135123&form=6&db=m ADAMTS1 Promotes Adhesion to Extracellular Matrix Proteins and Predicts Prognosis in Early Stage Breast Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31444237&form=6&db=m Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-?. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31638975&form=6&db=m Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31671408&form=6&db=m Leptin induces cell migration and invasion in a FAK-Src-dependent manner in breast cancer cells. ongoing research,unassigned 4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31820782&form=6&db=m SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31922434&form=6&db=m Expression of MiR-335 and its target metalloproteinase genes: clinical significance in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723034&form=6&db=m Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32782317&form=6&db=m The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers. diagnostic usage,unassigned 3,0 3.4.24.77 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33114046&form=6&db=m Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas. ongoing research,unassigned 2,0 3.4.24.77 Bronchiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7924484&form=6&db=m Gelatinolytic and type IV collagenolytic activity in bronchiectasis. diagnostic usage,unassigned 3,0 3.4.24.77 Bronchiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493662&form=6&db=m Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.77 Bronchiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25929954&form=6&db=m Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2 3.4.24.77 Bronchiolitis Obliterans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17524078&form=6&db=m Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Bronchiolitis Obliterans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25651312&form=6&db=m Metalloproteinase Profiling in Lung Transplant Recipients With Good Outcome and Bronchiolitis Obliterans Syndrome. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Bronchitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863647&form=6&db=m Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8913271&form=6&db=m Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Bursitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604641&form=6&db=m Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factor-beta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 CADASIL http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25846589&form=6&db=m [Subcortical ischemic vascular dementia: lesson from hereditary cerebral small vessel disease]. ongoing research,unassigned 3,0 3.4.24.77 CADASIL http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27476853&form=6&db=m Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics. therapeutic application,unassigned 2,0 3.4.24.77 Calciphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739520&form=6&db=m Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases. unassigned - 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1506780&form=6&db=m Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7882342&form=6&db=m Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8068181&form=6&db=m A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9037065&form=6&db=m Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140879&form=6&db=m Antisense IL-10 abrogates the inhibitory effects of IL-10 production by transfected tumor cells. causal interaction,unassigned 4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306456&form=6&db=m CpG island methylation in premalignant stages of gastric carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429784&form=6&db=m Role of matrix metalloproteinase-9 in progression of mouse skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208745&form=6&db=m Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355971&form=6&db=m Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309826&form=6&db=m Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17106710&form=6&db=m ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis. causal interaction,unassigned 3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17131304&form=6&db=m Prominent expression of metalloproteinases in early stages of ovarian tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18392134&form=6&db=m Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18394187&form=6&db=m Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18651826&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: prognostic implications. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536854&form=6&db=m Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19726678&form=6&db=m MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to Sorafenib. diagnostic usage,unassigned 1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032387&form=6&db=m Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346171&form=6&db=m MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21283680&form=6&db=m The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21744247&form=6&db=m Matrix metalloproteinases in tumorigenesis: an evolving paradigm. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427646&form=6&db=m Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. causal interaction,unassigned 4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23832774&form=6&db=m Transcript response of soft coral (Scleronephthya gracillimum) on exposure to polycyclic aromatic hydrocarbons. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936642&form=6&db=m Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24065230&form=6&db=m Kaposi' s sarcoma in HIV-positive patients: the state of art in the HAART-era. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24115089&form=6&db=m Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth. causal interaction,unassigned 3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24119788&form=6&db=m MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24381415&form=6&db=m No Association of Matrix Metalloproteinase [MMP]-2 (-735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (-418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444603&form=6&db=m Upregulated miR-106a plays an oncogenic role in pancreatic cancer. causal interaction,unassigned 3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24465799&form=6&db=m ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24489925&form=6&db=m The role of matrix metalloproteinase in the intimal sarcoma-like cells derived from endarterectomized tissues from a chronic thromboembolic pulmonary hypertension patient. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24622463&form=6&db=m Determining the combined effect on invasiveness and carcinogenesis process: matrix metalloproteinas/tissue inhibitor of metalloproteinase ratio. ongoing research,unassigned 2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24978432&form=6&db=m Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs). therapeutic application,unassigned 1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213697&form=6&db=m miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26024798&form=6&db=m Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26035830&form=6&db=m Inflammatory and repair pathways induced in human bronchoalveolar lavage cells with ozone inhalation. causal interaction,unassigned 1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26425438&form=6&db=m A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma. causal interaction,unassigned 4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26634009&form=6&db=m Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27120788&form=6&db=m Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28028989&form=6&db=m Thymosin ? as an Actin-binding Protein with a Variety of Functions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260063&form=6&db=m ADAM9 functions as a promoter of gastric cancer growth which is negatively and post-transcriptionally regulated by miR-126. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28693294&form=6&db=m Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207990&form=6&db=m Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29669932&form=6&db=m Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29996935&form=6&db=m ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982664&form=6&db=m Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment. unassigned - 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31285548&form=6&db=m Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31576012&form=6&db=m Correction: Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31585862&form=6&db=m Inflammatory markers in cancer: Potential resources. causal interaction,unassigned 1,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31709196&form=6&db=m Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin. causal interaction,unassigned 2,0 3.4.24.77 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33348378&form=6&db=m A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. therapeutic application,unassigned 1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1289671&form=6&db=m New relationships between prostatic intraepithelial neoplasia and prostatic carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1302559&form=6&db=m Urinary type IV collagenase: elevated levels are associated with bladder transitional cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323216&form=6&db=m Interstitial collagenase gene expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646178&form=6&db=m Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1928226&form=6&db=m The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2032422&form=6&db=m Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2045200&form=6&db=m Constitutive expression and secretion of proteases in non-metastatic SP1 mammary carcinoma cells and its metastatic sublines. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168868&form=6&db=m Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2253219&form=6&db=m Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535940&form=6&db=m Identification of a metalloproteinase co-purifying with rat tumour collagenase and the characteristics of fragments of both enzymes. ongoing research,unassigned 3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3366242&form=6&db=m High molecular mass type i.v. collagen-specific metalloprotease from human carcinoma tissue. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7506494&form=6&db=m Alveolar macrophage secretion of a 92-kDa gelatinase in response to bleomycin. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7661515&form=6&db=m Analysis of expression of matrix metalloproteinases-2 and -9 in hypopharyngeal squamous cell carcinoma by in situ hybridization. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688350&form=6&db=m Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7812956&form=6&db=m Correlation of the in situ detection of polymerase chain reaction-amplified metalloproteinase complementary DNAs and their inhibitors with prognosis in cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012988&form=6&db=m Autocrine factor enhancing the secretion of M(r) 95,000 gelatinase (matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8019490&form=6&db=m Gelatinases and metalloproteinase inhibitor secreted by murine colonic carcinoma cells with differing metastatic potential. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020584&form=6&db=m Paracrine factor and cell-cell contact-mediated induction of protease and c-ets gene expression in malignant keratinocyte/dermal fibroblast cocultures. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8062282&form=6&db=m Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8314798&form=6&db=m Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384265&form=6&db=m Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8560972&form=6&db=m White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues. causal interaction,unassigned 3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626123&form=6&db=m Recurrence patterns in locally advanced cervical carcinoma: role of nodal status and 72-kDa metalloproteinase index. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626132&form=6&db=m Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631550&form=6&db=m The 72-kDa metalloproteinase immunostaining in cervical carcinoma: relationship with lymph nodal involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8683728&form=6&db=m Exposure to vinorelbine inhibits in vitro proliferation and invasiveness of transitional cell bladder carcinoma. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8980245&form=6&db=m High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8996535&form=6&db=m Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell-cell contact. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9056412&form=6&db=m Melanocyte mediated paracrine induction of extracellular matrix degrading proteases in squamous cell carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9099978&form=6&db=m Stromelysin-3 expression in early (pT1) carcinomas and pseudoinvasive lesions of the colorectum. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9185711&form=6&db=m In situ detection of PCR-amplified metalloproteinase cDNAs, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9275032&form=6&db=m Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486578&form=6&db=m The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9609547&form=6&db=m Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9748137&form=6&db=m Augmented membrane type 1 matrix metalloproteinase (MT1-MMP):MMP-2 messenger RNA ratio in gastric carcinomas with poor prognosis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9772531&form=6&db=m [Effects of TIMP-2 gene transfection on biological behaviors of a metastatic human lung carcinoma cell line] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9783985&form=6&db=m Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10026853&form=6&db=m Tissue inhibitor of metalloproteinase expression. A target for gene therapy in renal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10197640&form=6&db=m Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218674&form=6&db=m Expression of stromelysin 3 in keratoarcanthoma and squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10416584&form=6&db=m Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10486468&form=6&db=m Effect of human seminal fluid on production of messenger ribonucleic acid for metalloproteinase 2 and metalloproteinase 9 in cervical epithelial carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10622253&form=6&db=m EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10685633&form=6&db=m Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11189300&form=6&db=m [Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306456&form=6&db=m CpG island methylation in premalignant stages of gastric carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342973&form=6&db=m Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11640889&form=6&db=m Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11844598&form=6&db=m Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11925127&form=6&db=m Anti-invasive effect of MMI-166, a new selective matrix metalloproteinase inhibitor, in cervical carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169394&form=6&db=m Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma. ongoing research,unassigned 2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384986&form=6&db=m Inhibition of epidermal growth factor-induced invasion by dexamethasone and AP-1 decoy in human squamous cell carcinoma cell lines. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452001&form=6&db=m [Relationship of expression unbalance of matrix metalloproteinase and tissue inhibitor of metalloproteinase to invasiveness and metastasis in gastric carcinomas] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527751&form=6&db=m Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. unassigned - 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12693939&form=6&db=m Probing the dimeric structure of porcine aminoacylase 1 by mass spectrometric and modeling procedures. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727852&form=6&db=m Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743035&form=6&db=m TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866360&form=6&db=m Metalloprotease-specific poly(ethylene glycol) methyl ether-peptide-doxorubicin conjugate for targeting anticancer drug delivery based on angiogenesis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12897567&form=6&db=m Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14522908&form=6&db=m Dual stromelysin-3 function during natural mouse mammary tumor virus-ras tumor progression. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14598888&form=6&db=m The metalloproteinase inhibitor TIMP-2 is down-regulated by androgens in LNCaP prostate carcinoma cells. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623253&form=6&db=m Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744773&form=6&db=m Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15006646&form=6&db=m Beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026328&form=6&db=m Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. ongoing research,unassigned 3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15028476&form=6&db=m Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167830&form=6&db=m Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15337756&form=6&db=m Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15583833&form=6&db=m Role of beta2-chimaerin in the behaviour of murine mammary carcinoma cells in response to extracellular matrix components. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15642389&form=6&db=m Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation. diagnostic usage,unassigned 3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781321&form=6&db=m Effects of basic fibroblast factor (bFGF) on MMP-2, TIMP-2, and type-I collagen levels in human lung carcinoma fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816845&form=6&db=m Matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15831673&form=6&db=m Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16116499&form=6&db=m Prognostic value of microvessel density, matrix metalloproteinase-9 and p53 protein expression in esophageal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16142392&form=6&db=m Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230393&form=6&db=m Critical function for ADAM9 in mouse prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309826&form=6&db=m Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495931&form=6&db=m Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16607276&form=6&db=m ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16771728&form=6&db=m Increasing expression of extracellular matrix metalloprotease inducer in renal cell carcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204469&form=6&db=m MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17572184&form=6&db=m Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17657847&form=6&db=m Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786346&form=6&db=m Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999917&form=6&db=m Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171982&form=6&db=m The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18186556&form=6&db=m Methylation of TIMP3 in esophageal squamous cell carcinoma. ongoing research,unassigned 3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18582378&form=6&db=m ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18630474&form=6&db=m The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18755499&form=6&db=m Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18931526&form=6&db=m In vivo Efficacy of Marimastat and Chemoradiation in Head and Neck Cancer Xenografts. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18951930&form=6&db=m AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015455&form=6&db=m Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047908&form=6&db=m Relation between laminin-5 gamma 2 chain and cell surface metalloproteinase MT1-MMP in clear cell carcinoma of the ovary. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19548138&form=6&db=m CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19574900&form=6&db=m Therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma is associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638407&form=6&db=m The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776700&form=6&db=m Elevated levels of serum metalloproteinase 9 in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20211016&form=6&db=m CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus. unassigned - 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551050&form=6&db=m Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. causal interaction,unassigned 2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20718757&form=6&db=m Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-?-disrupted diffuse-type gastric carcinoma. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21244194&form=6&db=m Relationship between metalloprotease expression in tumour and stromal cells and aggressive behaviour in prostate carcinoma: Simultaneous high-throughput study of multiple metalloproteases and their inhibitors using tissue array analysis of radical prostatectomy samples. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21624249&form=6&db=m [Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma]. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21986939&form=6&db=m A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001177&form=6&db=m The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22636800&form=6&db=m Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22769410&form=6&db=m The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22966365&form=6&db=m Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23157925&form=6&db=m Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441135&form=6&db=m MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23514059&form=6&db=m Overexpression of ADAM9 Promotes Colon Cancer Cells Invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23551625&form=6&db=m Immunohistochemical analysis on potential new molecular targets for esophageal cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24007880&form=6&db=m Src Plays a Key Role in ADAM28 Expression in v-src-Transformed Epithelial Cells and Human Carcinoma Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184540&form=6&db=m The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24356192&form=6&db=m Differential expression of degradome components in cutaneous squamous cell carcinomas. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24626788&form=6&db=m ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231630&form=6&db=m Thrombin conducts epithelial?mesenchymal transition via protease?activated receptor?1 in human gastric cancer. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25739392&form=6&db=m Mangiferin inhibits tumor necrosis factor-?-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-?B activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25771900&form=6&db=m Prognostic significance of TIMP-2, MMP-2, and MMP-9 on high-grade serous ovarian carcinoma using digital image analysis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25824133&form=6&db=m Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25956455&form=6&db=m Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25966212&form=6&db=m Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26918856&form=6&db=m ADAM28 is expressed by epithelial cells in human normal tissues And protects from C1q-induced cell death. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26979595&form=6&db=m Expression and characterization of tissue inhibitor of metalloproteinase 4 from complex canine mammary carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26981956&form=6&db=m Overexpression of ADAM9 Promotes Colon Cancer Cells Invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27356690&form=6&db=m Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27571068&form=6&db=m ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29193730&form=6&db=m The 3p14.2 tumour suppressor ADAMTS9 is inactivated by promoter CpG methylation and inhibits tumour cell growth in breast cancer. unassigned - 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29312740&form=6&db=m Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29882245&form=6&db=m SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186750&form=6&db=m Death receptor 6 promotes ovarian cancer cell migration through KIF11. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30190423&form=6&db=m Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis. ongoing research,unassigned 3,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194665&form=6&db=m Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance. unassigned - 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33548228&form=6&db=m The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer. ongoing research,unassigned 2,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34513052&form=6&db=m Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9609547&form=6&db=m Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11189300&form=6&db=m [Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10218674&form=6&db=m Expression of stromelysin 3 in keratoarcanthoma and squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.4.24.77 Carcinoma, Bronchogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2280991&form=6&db=m Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19700750&form=6&db=m Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236691&form=6&db=m Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29860265&form=6&db=m Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.24.77 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2081460&form=6&db=m Expression of extracellular matrix-degrading metalloproteinases and metalloproteinase inhibitors is developmentally regulated during endoderm differentiation of embryonal carcinoma cells. unassigned - 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848028&form=6&db=m Metalloendoprotease inhibitors block protein synthesis, intracellular transport, and endocytosis in hepatoma cells. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228126&form=6&db=m Serum collagenase activity in patients with chronic liver disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8751912&form=6&db=m Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9075667&form=6&db=m In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. unassigned - 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10697530&form=6&db=m Dibutyryl cyclic AMP-induced enhancement of tissue inhibitor of metalloproteinases-3 expression and its possible relation to the invasive activity of the human hepatoma cell line PLC/PRF/5. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14515040&form=6&db=m [Clinical usefulness of plasma activities of gelatinase (matrix metalloproteinase-2 and 9) in chronic liver disease] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754388&form=6&db=m Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: relevance to intracellular signaling pathways. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870919&form=6&db=m Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474379&form=6&db=m Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16978202&form=6&db=m Increasing EMMPRIN and matriptase expression in hepatocellular carcinoma: tissue microarray analysis of immunohistochemical scores with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452483&form=6&db=m Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18997101&form=6&db=m Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19528495&form=6&db=m Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20099300&form=6&db=m Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21520171&form=6&db=m Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance. causal interaction,unassigned 4,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21530512&form=6&db=m microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma. causal interaction,unassigned 1,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546345&form=6&db=m Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells. unassigned - 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23598435&form=6&db=m Ultrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23670717&form=6&db=m Krüppel?like factor expression and correlation with FAK, MMP?9 and E?cadherin expression in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24670536&form=6&db=m A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25585999&form=6&db=m The important role of ADAM8 in the progression of hepatocellular carcinoma induced by diethylnitrosamine in mice. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26179263&form=6&db=m miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26677209&form=6&db=m Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29120572&form=6&db=m Gene polymorphisms of Interleukin 1? and Metalloproteinase 3 in Hepatitis C Infected Patients and Hepatocellular Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29138461&form=6&db=m Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30925457&form=6&db=m Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31663692&form=6&db=m Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32245188&form=6&db=m A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33314720&form=6&db=m Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34392581&form=6&db=m Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.24.77 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528498&form=6&db=m Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19700750&form=6&db=m Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236691&form=6&db=m Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32352029&form=6&db=m BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866360&form=6&db=m Metalloprotease-specific poly(ethylene glycol) methyl ether-peptide-doxorubicin conjugate for targeting anticancer drug delivery based on angiogenesis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384265&form=6&db=m Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10430098&form=6&db=m Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740999&form=6&db=m Angiogenesis inhibitors in the treatment of lung cancer. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526122&form=6&db=m Serum tissue inhibitors of metalloproteinase-1 and -2 in patients with non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15832061&form=6&db=m Cerebral ischemic events in patients with advanced lung or prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15886272&form=6&db=m Changes in angiogenic growth factor levels after gefitinib treatment in non-small cell lung cancer. ongoing research,unassigned 3,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495931&form=6&db=m Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118669&form=6&db=m Video-assisted thoracic surgery lobectomy for lung cancer is associated with less immunochemokine disturbances than thoracotomy. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17874625&form=6&db=m [The serum concentration of metalloproteinase 9 and 2 in non-small cell lung cancer patients] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18710625&form=6&db=m [Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22354764&form=6&db=m Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. diagnostic usage,unassigned 3,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982189&form=6&db=m Loss of TIMP-3 Promotes Tumor Invasion via Elevated IL-6 Production and Predicts Poor Survival and Relapse in HPV-Infected Non-Small Cell Lung Cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24626788&form=6&db=m ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893726&form=6&db=m Combined RNAi targeting human Stat3 and ADAM9 as gene therapy for non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207990&form=6&db=m Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.4.24.77 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29312740&form=6&db=m Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.77 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17114341&form=6&db=m Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid-induced epithelial ovarian cancer invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25720282&form=6&db=m [Expression and activity of proteases in metastasis of ovarian cancer]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.24.77 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602775&form=6&db=m Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28662671&form=6&db=m Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31062766&form=6&db=m Tripartite Motif-Containing Protein 59 (TRIM59) Promotes Epithelial Ovarian Cancer Progression via the Focal Adhesion Kinase(FAK)/AKT/Matrix Metalloproteinase (MMP) Pathway. unassigned - 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7510000&form=6&db=m Endothelin-2-converting enzyme from human renal adenocarcinoma cells is a phosphoramidon-sensitive, membrane-bound metalloprotease. ongoing research,unassigned 3,0 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9783985&form=6&db=m Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10026853&form=6&db=m Tissue inhibitor of metalloproteinase expression. A target for gene therapy in renal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16771728&form=6&db=m Increasing expression of extracellular matrix metalloprotease inducer in renal cell carcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17572184&form=6&db=m Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18582378&form=6&db=m ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19548138&form=6&db=m CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441135&form=6&db=m MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.24.77 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34513052&form=6&db=m Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323216&form=6&db=m Interstitial collagenase gene expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1327511&form=6&db=m Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1928226&form=6&db=m The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020584&form=6&db=m Paracrine factor and cell-cell contact-mediated induction of protease and c-ets gene expression in malignant keratinocyte/dermal fibroblast cocultures. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8996535&form=6&db=m Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell-cell contact. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9056412&form=6&db=m Melanocyte mediated paracrine induction of extracellular matrix degrading proteases in squamous cell carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11640889&form=6&db=m Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384986&form=6&db=m Inhibition of epidermal growth factor-induced invasion by dexamethasone and AP-1 decoy in human squamous cell carcinoma cell lines. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743035&form=6&db=m TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15831673&form=6&db=m Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204469&form=6&db=m MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18755499&form=6&db=m Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015455&form=6&db=m Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19574900&form=6&db=m Therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma is associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21624249&form=6&db=m [Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma]. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21986939&form=6&db=m A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24356192&form=6&db=m Differential expression of degradome components in cutaneous squamous cell carcinomas. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27356690&form=6&db=m Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1302559&form=6&db=m Urinary type IV collagenase: elevated levels are associated with bladder transitional cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8683728&form=6&db=m Exposure to vinorelbine inhibits in vitro proliferation and invasiveness of transitional cell bladder carcinoma. ongoing research,unassigned 4,0 3.4.24.77 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10685633&form=6&db=m Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342973&form=6&db=m Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15028476&form=6&db=m Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22966365&form=6&db=m Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786904&form=6&db=m Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12397684&form=6&db=m [The role of HB-EGF in angiotensin II--signaling] causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12755001&form=6&db=m [Membrane-anchored heparin-binding EGF-like growth factor processing by ADAM12 in cardiac hypertrophy] causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767723&form=6&db=m A central role of EGF receptor transactivation in angiotensin II -induced cardiac hypertrophy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14645255&form=6&db=m Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17975115&form=6&db=m In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. unassigned - 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19398663&form=6&db=m Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327331&form=6&db=m Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of SGK-1. causal interaction,unassigned 2,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23850346&form=6&db=m Upregulation of Nox4 Promotes Angiotensin II-Induced Epidermal Growth Factor Receptor Activation and Subsequent Cardiac Hypertrophy by Increasing ADAM17 Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28373586&form=6&db=m Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31774689&form=6&db=m A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16275197&form=6&db=m Comparison of levels of matrix metalloproteinase-2 and -3 in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3 3.4.24.77 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16612065&form=6&db=m Changes in Metalloproteinase and Tissue Inhibitor of Metalloproteinase during Tachycardia-Induced Cardiomyopathy by Rapid Atrial Pacing in Dogs. ongoing research,unassigned 3,0 3.4.24.77 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828340&form=6&db=m Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs. ongoing research,unassigned 4,0 3.4.24.77 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8623931&form=6&db=m Remodeling of human myocardial collagen in idiopathic dilated cardiomyopathy. Role of metalloproteinases and pyridinoline cross-links. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.77 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646678&form=6&db=m Impact of Pycnogenol on cardiac extracellular matrix remodeling induced by L-NAME administration to old mice. causal interaction,unassigned 1,0 3.4.24.77 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20977821&form=6&db=m Plasma profiling determinants of matrix homeostasis in paediatric dilated cardiomyopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.4.24.77 Cardiomyopathy, Hypertrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21890325&form=6&db=m Plasma metalloproteinase levels and left ventricular remodeling in hypertrophic cardiomyopathy in patients with an identical mutation. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678337&form=6&db=m Vasopeptidase inhibitors: will they have a role in clinical practice? causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19943213&form=6&db=m Coronary Artery Disease - Eighth International Congress. From prevention to intervention. therapeutic application,unassigned 4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20687985&form=6&db=m [Association of gamma glutamyltransferase, metabolic syndrome and cardiovascular risk] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21079048&form=6&db=m MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24506074&form=6&db=m Inducible reduction in pregnancy-associated plasma protein-a gene expression inhibits established atherosclerotic plaque progression in mice. causal interaction,unassigned 3,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24871629&form=6&db=m Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1? causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26703451&form=6&db=m Hypothesis: Metalloproteinase Inhibitors Decrease Risks of Cardiovascular Disease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26733326&form=6&db=m Targeted Inhibition of Pregnancy-Associated Plasma Protein-A Activity Reduces Atherosclerotic Plaque Burden in Mice. causal interaction,unassigned 4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27007282&form=6&db=m Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-?B axis. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27166361&form=6&db=m Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28595793&form=6&db=m Selenium modulates MMP2 expression through the TGF?1/Smad signalling pathway in human umbilical vein endothelial cells and rabbits following lipid disturbance. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28911167&form=6&db=m In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice. causal interaction,unassigned 4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30187439&form=6&db=m The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075797&form=6&db=m Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity. causal interaction,unassigned 4,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31929842&form=6&db=m ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.24.77 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275517&form=6&db=m Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones. causal interaction,unassigned 3,0 3.4.24.77 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24432723&form=6&db=m MMP-12 as a new marker of Stanford-A acute aortic dissection. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,3 3.4.24.77 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672747&form=6&db=m NGAL and MMP-9/NGAL as biomarkers of plaque vulnerability and targets of statins in patients with carotid atherosclerosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32101136&form=6&db=m Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.77 cathepsin l deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21899497&form=6&db=m Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. causal interaction,unassigned 4,0 3.4.24.77 cathepsin l deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21972973&form=6&db=m Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. causal interaction,unassigned 4,0 3.4.24.77 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7831705&form=6&db=m Collagenase-induced intrastriatal hemorrhage in rats results in long-term locomotor deficits. unassigned - 3.4.24.77 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109878&form=6&db=m Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740200&form=6&db=m Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31721277&form=6&db=m Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study. ongoing research,therapeutic application,unassigned 2,3,0 3.4.24.77 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626132&form=6&db=m Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317213&form=6&db=m Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling. ongoing research,unassigned 2,0 3.4.24.77 Charcot-Marie-Tooth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30415211&form=6&db=m Characterising the phenotype and mode of inheritance of patients with inherited peripheral neuropathies carrying MME mutations. causal interaction,unassigned 2,0 3.4.24.77 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19296468&form=6&db=m MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25435928&form=6&db=m Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32187046&form=6&db=m Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13. causal interaction,unassigned 4,0 3.4.24.77 Cholangitis, Sclerosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11438501&form=6&db=m A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3297167&form=6&db=m Vibrio cholerae metalloproteinase degrades intestinal mucin and facilitates enterotoxin-induced secretion from rat intestine. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10831601&form=6&db=m A dipeptide metalloendoprotease substrate completely blocks the response of cells in culture to cholera toxin. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14585681&form=6&db=m Cholera vaccine candidate 638: intranasal immunogenicity and expression of a foreign antigen from the pulmonary pathogen Coccidioides immitis. unassigned - 3.4.24.77 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21054266&form=6&db=m Structural characterization of metalloprotease vibriolysin of cholera pathogen Vibrio cholerae. ongoing research,unassigned 3,0 3.4.24.77 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26952544&form=6&db=m Vibrio cholerae hemagglutinin(HA)/protease: An extracellular metalloprotease with multiple pathogenic activities. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013773&form=6&db=m Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Cholestasis, Intrahepatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363034&form=6&db=m Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.77 Cholesteatoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23318052&form=6&db=m Expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.4.24.77 Cholesteatoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32740796&form=6&db=m Evaluation of significant gene expression changes in congenital and acquired cholesteatoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Chondroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896699&form=6&db=m Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2975581&form=6&db=m Degradation of rat chondrosarcoma proteoglycans by a neutral metalloprotease from rabbit chondrocytes. ongoing research,unassigned 2,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8123044&form=6&db=m Production of matrix metalloproteinases and a metalloproteinase inhibitor by swarm rat chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9065576&form=6&db=m Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas. causal interaction,unassigned 4,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469303&form=6&db=m Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473866&form=6&db=m Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14701864&form=6&db=m ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. ongoing research,unassigned 1,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499569&form=6&db=m siRNA mediated inhibition of MMP-1 reduces invasive potential of a human chondrosarcoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736455&form=6&db=m Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391840&form=6&db=m Interleukin-10 does not affect IL-1-induced interleukin-6 and metalloproteinase production in human chondrosarcoma cells, SW1353. ongoing research,unassigned 1,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16549373&form=6&db=m Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896699&form=6&db=m Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25760020&form=6&db=m Interleukin-1? induced nuclear factor-?B binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells. ongoing research,unassigned 4,0 3.4.24.77 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672103&form=6&db=m Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Chorioamnionitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20136828&form=6&db=m SAR150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912288&form=6&db=m Reduced expression of tissue inhibitor of metalloproteinase (TIMP)-2 in gestational trophoblastic diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 3.4.24.77 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297175&form=6&db=m Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15448160&form=6&db=m Inhibition of cytotrophoblastic (JEG-3) cell invasion by interleukin 12 involves an interferon gamma-mediated pathway. ongoing research,unassigned 4,0 3.4.24.77 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17576752&form=6&db=m The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS): trophoblast invasiveness and APS animal model. ongoing research,unassigned 3,0 3.4.24.77 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23427184&form=6&db=m Overexpression of Endogenous TIMP-2 Increases the Proliferation of BeWo Choriocarcinoma Cells Through the MAPK-Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14586590&form=6&db=m Reduction of experimental laser-induced choroidal neovascularization by orally administered BPHA, a selective metalloproteinase inhibitor. therapeutic application,unassigned 4,0 3.4.24.77 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31757977&form=6&db=m Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism. causal interaction,unassigned 2,0 3.4.24.77 Chronic Kidney Disease-Mineral and Bone Disorder http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29056164&form=6&db=m ADAM17, a New Player in the Pathogenesis of Chronic Kidney Disease-Mineral and Bone Disorder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716308&form=6&db=m MMP-13 and TIMP-1 determinations in progressive chronic periodontitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536195&form=6&db=m Erratum: Elastase and metalloproteinase 9 concentrations in saliva in patients with chronic periodontitis. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0 3.4.24.77 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27859260&form=6&db=m Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.24.77 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28326725&form=6&db=m [Analysis of salivary protease spectrum in chronic periodontitis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30384155&form=6&db=m Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis. diagnostic usage,unassigned 3,0 3.4.24.77 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516010&form=6&db=m [Effect of the management of class I obesity with metformin on metalloproteinase activity in patients with chronic periodontitis]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17898182&form=6&db=m Anaplasma phagocytophilum-Borrelia burgdorferi coinfection enhances chemokine, cytokine, and matrix metalloprotease expression by human brain microvascular endothelial cells. ongoing research,unassigned 4,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16344067&form=6&db=m Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467915&form=6&db=m Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2? causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21699778&form=6&db=m Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation. ongoing research,unassigned 4,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22119283&form=6&db=m Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24465207&form=6&db=m Absence of intestinal PPAR? aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway. unassigned - 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25790743&form=6&db=m Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine. ongoing research,unassigned 3,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27379832&form=6&db=m Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain. unassigned - 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27861153&form=6&db=m Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. causal interaction,unassigned 2,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31467484&form=6&db=m Treatment with a Zinc Metalloprotease Purified from Bothrops moojeni Snake Venom (BmooMP-Alpha-I) Reduces the Inflammation in an Experimental Model of Dextran Sulfate Sodium-Induced Colitis. ongoing research,therapeutic application,unassigned 2,4,0 3.4.24.77 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31540059&form=6&db=m Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-??. unassigned - 3.4.24.77 Colitis, Collagenous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433942&form=6&db=m Fibrogenesis and fibrolysis in collagenous colitis. Patterns of procollagen types I and IV, matrix-metalloproteinase-1 and -13, and TIMP-1 gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.77 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8577260&form=6&db=m Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10500063&form=6&db=m Matrix metalloproteinase levels are elevated in inflammatory bowel disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12112311&form=6&db=m Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12651627&form=6&db=m Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23323009&form=6&db=m Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27861153&form=6&db=m Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. causal interaction,unassigned 2,0 3.4.24.77 Coloboma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625437&form=6&db=m Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure. ongoing research,unassigned 2,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7596985&form=6&db=m Insulin-degrading enzyme in a human colon adenocarcinoma cell line (Caco-2). ongoing research,unassigned 4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9062395&form=6&db=m Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731514&form=6&db=m Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10426662&form=6&db=m Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545022&form=6&db=m TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment. therapeutic application,unassigned 3,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11399950&form=6&db=m Retinoic acids reduce matrilysin (matrix metalloproteinase 7) and inhibit tumor cell invasion in human colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401321&form=6&db=m Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11640889&form=6&db=m Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15185339&form=6&db=m Glycine-extended gastrin induces matrix metalloproteinase-1- and -3-mediated invasion of human colon cancer cells through type I collagen gel and Matrigel. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16336960&form=6&db=m Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283136&form=6&db=m Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928719&form=6&db=m Modifying Effects of Dietary Factors on (-)-Epigallocatechin-3-gallate-induced Pro-matrix Metalloproteinase-7 Production in HT-29 Human Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638407&form=6&db=m The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20980803&form=6&db=m Differential regulation of MMP7 in colon cancer cells resistant and sensitive to oxaliplatin-induced cell death. causal interaction,unassigned 3,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245094&form=6&db=m Smad4 inactivation promotes malignancy and drug resistance of colon cancer. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22674854&form=6&db=m Restoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteinase expression and metastasis-associated activities in colon cancer cells. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22927434&form=6&db=m Extra- and Intracellular Imaging of human Matrix Metalloprotease 11 (hMMP-11) with a Cell-Penetrating FRET-Substrate. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22956286&form=6&db=m Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab. causal interaction,unassigned 4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24660995&form=6&db=m Combined Therapeutic Effects of Vinblastine and Astragalus Saponins in Human Colon Cancer Cells and Tumor Xenograft via Inhibition of Tumor Growth and Proangiogenic Factors. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25902005&form=6&db=m Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26030791&form=6&db=m Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32954649&form=6&db=m A disintegrin and metalloproteinase 8 induced epithelial-mesenchymal transition to promote the invasion of colon cancer cells via TGF-?/Smad2/3 signalling pathway. unassigned - 3.4.24.77 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063817&form=6&db=m A metalloproteinase of the disintegrin and metalloproteinases and the ThromboSpondin Motifs 6 as a novel marker for colon cancer: functional experiments. diagnostic usage,therapeutic application,unassigned 2,2,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7665251&form=6&db=m Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8548762&form=6&db=m Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8758934&form=6&db=m Correspondence re: N-B. Liabakk et al., matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res., 56: 190-196, 1966. ongoing research,unassigned 2,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9263524&form=6&db=m [Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9350241&form=6&db=m [Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545021&form=6&db=m Metastatic and non-metastatic colorectal cancer (CRC) cells induce host metalloproteinase production in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10901373&form=6&db=m Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10999465&form=6&db=m Simultaneous measurement of soluble carcinoembryonic antigen and the tissue inhibitor of metalloproteinase TIMP1 serum levels for use as markers of pre-invasive to invasive colorectal cancer. diagnostic usage,ongoing research,unassigned 4,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11106246&form=6&db=m High preoperative plasma tissue inhibitor of metalloproteinase-1 levels are associated with short survival of patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701845&form=6&db=m Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474169&form=6&db=m Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17264401&form=6&db=m Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17348445&form=6&db=m Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer. causal interaction,therapeutic application,unassigned 2,3,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17543340&form=6&db=m Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214300&form=6&db=m Matrix metalloproteinases 7 and 9 and their types 1 and 4 tissue inhibitors in tumors and plasma of patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19039945&form=6&db=m Matrix metalloproteinases 2, 3, 13 and their type 2 tissue inhibitor in tumors and plasma of patients with colorectal cancer. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19458070&form=6&db=m Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19569245&form=6&db=m Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032387&form=6&db=m Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20187509&form=6&db=m Clinicopathological analysis of colorectal cancers in the elderly. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617211&form=6&db=m Heterogeneity of metalloproteinase expression in colorectal cancer - relation of molecular findings to basic morphology. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21730794&form=6&db=m Gene expression of vascular endothelial growth factor a, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients. ongoing research,therapeutic application,unassigned 3,2,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22096485&form=6&db=m Enhanced activity of meprin-?, a pro-migratory and pro-angiogenic protease, in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923609&form=6&db=m Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. causal interaction,unassigned 2,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24050546&form=6&db=m MicroRNA-191 correlates with poor prognosis of colorectal carcinoma and plays multiple roles by targeting tissue inhibitor of metalloprotease 3. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,2 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24195505&form=6&db=m MicroRNA-191 correlates with poor prognosis of colorectal carcinoma and plays multiple roles by targeting tissue inhibitor of metalloprotease 3. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25098630&form=6&db=m Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26565752&form=6&db=m Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744411&form=6&db=m A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808125&form=6&db=m Clinicopathologic and Prognostic Significance of Metalloproteinase Tissue Inhibitor-2 Promoters in Tunisian Colorectal Cancer: A Case-Control Study. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27517630&form=6&db=m Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27661126&form=6&db=m MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28529592&form=6&db=m Unique insight into microenvironmental changes in colorectal cancer: Ex vivo assessment of matrix metalloprotease-mediated molecular changes in human colorectal tumor tissue and corresponding non-neoplastic adjacent tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29029414&form=6&db=m Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29143120&form=6&db=m Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30789913&form=6&db=m Netrin-1 plays a role in the effect of moderate exercise on myocardial fibrosis in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30940630&form=6&db=m Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol. unassigned - 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988064&form=6&db=m Strong association of tissue inhibitor of metalloproteinase (TIMP)-2 and -3 promoter single nucleotide polymorphisms with risk of colorectal cancer in ethnic Kashmiri population - a case control study. diagnostic usage,unassigned 3,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32200451&form=6&db=m TIMP1 intron 3 retention is a marker of colon cancer progression controlled by hnRNPA1. causal interaction,unassigned 4,0 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043016&form=6&db=m Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of ?-Catenin, BRG1, and KDM4. unassigned - 3.4.24.77 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33946534&form=6&db=m Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metalloprotease 1 Expression by Mucosal Stromal Cells and Colorectal Cancer Development in Inflammatory Bowel Disease. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527702&form=6&db=m Extracellular Matrix Enzymes and Immune Cell Biology. ongoing research,unassigned 3,0 3.4.24.77 Cone-Rod Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20806078&form=6&db=m An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10413876&form=6&db=m An evaluation of chromogenic substrates for characterization of serine protease produced by pathogenic Vibrio alginolyticus. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901144&form=6&db=m Pathogenesis of thrombotic thrombocytopenic purpura. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Connective Tissue Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27582494&form=6&db=m Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Connective Tissue Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32728521&form=6&db=m Hypertensive emergency presenting with diffuse alveolar hemorrhaging and thrombotic microangiopathy: A case report and review of the literature. causal interaction,diagnostic usage,unassigned 1,4,0 3.4.24.77 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9665512&form=6&db=m Mechanical stress in vitro induces increased expression of MMPs 2 and 9 in excised Dupuytren's disease tissue. therapeutic application,unassigned 2,0 3.4.24.77 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19053961&form=6&db=m Delayed neovascularization in inflammation-induced corneal neovascularization in interleukin-10-deficient mice. therapeutic application,unassigned 1,0 3.4.24.77 Corneal Opacity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27687499&form=6&db=m Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. causal interaction,unassigned 3,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14577520&form=6&db=m Serum metalloproteinase 9 levels in patients with coronary artery disease: a novel marker of inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15261932&form=6&db=m Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16942771&form=6&db=m Urinary levels of matrix metalloproteinase 9 and 2 and tissue inhibitor of matrix metalloproteinase in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16960505&form=6&db=m Do metalloproteinases destabilize vulnerable atherosclerotic plaques? causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893005&form=6&db=m Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18260930&form=6&db=m [Activity of inflammatory-destructive changes in the process of formation of unstable atherosclerotic plaque] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19656094&form=6&db=m [Changes in proinflammatory cytokine and destructive metalloproteinase levels during formation of unstable atherosclerotic plaque] causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20152234&form=6&db=m Relation of matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio in peripheral circulating CD14+ monocytes to progression of coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946608&form=6&db=m Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22839584&form=6&db=m [Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood]. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25712208&form=6&db=m ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1. causal interaction,unassigned 4,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536857&form=6&db=m Protective effect of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 haplotype on coronary artery disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27781958&form=6&db=m Metalloproteinase 2 and 9 Activity Increase in Epicardial Adipose Tissue of Patients with Coronary Artery Disease. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27902619&form=6&db=m Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease. causal interaction,unassigned 1,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28623250&form=6&db=m ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis. causal interaction,unassigned 4,0 3.4.24.77 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33761760&form=6&db=m Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892341&form=6&db=m Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174457&form=6&db=m Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 3.4.24.77 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22929563&form=6&db=m Effect of matrix metalloproteinase and their inhibitors on atrial myocardial structural remodeling. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Coronary Restenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868002&form=6&db=m [Batimastat-eluting stent implantation for the treatment of coronary artery disease: results of the Brazilian pilot study] causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Coronary Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181741&form=6&db=m Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32185952&form=6&db=m Effect of Xiaochuanping powder on the inflammatory response and airway remodeling in asthmatic rats. therapeutic application,unassigned 1,0 3.4.24.77 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844538&form=6&db=m Alpha-1-antitrypsin: A possible host protective factor against Covid-19. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.24.77 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32867008&form=6&db=m Potential interactions of SARS-CoV-2 with human cell receptors in the skin: understanding the enigma for a lower frequency of skin lesions compared to other tissues. unassigned - 3.4.24.77 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117379&form=6&db=m ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33483858&form=6&db=m Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage. therapeutic application,unassigned 2,0 3.4.24.77 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33957057&form=6&db=m The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19. ongoing research,unassigned 2,0 3.4.24.77 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405070&form=6&db=m A Case of COVID-19 Induced Thrombotic Thrombocytopenic Purpura. causal interaction,unassigned 4,0 3.4.24.77 Cowpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594571&form=6&db=m ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity. unassigned - 3.4.24.77 Craniosynostoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18924166&form=6&db=m Cytogenetic and array CGH characterization of de novo 1p36 duplications and deletion in a patient with congenital cataracts, hearing loss, choanal atresia, and mental retardation. unassigned - 3.4.24.77 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8577260&form=6&db=m Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12651627&form=6&db=m Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Cystadenocarcinoma, Serous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8669868&form=6&db=m Tissue and serum metalloproteinase (MMP-2) expression in advanced ovarian serous cystoadenocarcinomas: clinical and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3454203&form=6&db=m Activity of the lysosomal cysteine proteinases (cathepsin B,H,L) and a metalloproteinase (MMP-7-ase) in the serum of cystic fibrosis homozygous children. diagnostic usage,unassigned 2,0 3.4.24.77 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19812235&form=6&db=m Locally produced relaxin may affect testis and vas deferens function in rats. unassigned - 3.4.24.77 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25929954&form=6&db=m Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2 3.4.24.77 Cysticercosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27095967&form=6&db=m Functionally Expression of Metalloproteinase in Taenia solium Metacestode and Its Evaluation for Serodiagnosis of Cysticercosis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181417&form=6&db=m A possible role for metalloproteinases in renal cyst development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12372462&form=6&db=m Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts. causal interaction,unassigned 2,0 3.4.24.77 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26510692&form=6&db=m Implication of thymoquinone as a remedy for polycystic ovary in rat. ongoing research,unassigned 2,0 3.4.24.77 Darier Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29634885&form=6&db=m A case of segmental Darier disease treated with doxycycline monotherapy. causal interaction,unassigned 2,0 3.4.24.77 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389903&form=6&db=m Catalytic activity of ADAM28. causal interaction,unassigned 3,0 3.4.24.77 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16496359&form=6&db=m Novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Dementia, Vascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17077200&form=6&db=m Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989572&form=6&db=m Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. ongoing research,unassigned 4,0 3.4.24.77 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865884&form=6&db=m Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29702687&form=6&db=m Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability. unassigned - 3.4.24.77 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11240267&form=6&db=m Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.4.24.77 Dermatitis, Allergic Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12013508&form=6&db=m Inhibition of contact hypersensitivity reaction to picryl chloride: effect of small molecular weight peptidomimetic compounds possessing inhibitory activity against metalloproteinases. therapeutic application,unassigned 4,0 3.4.24.77 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12361695&form=6&db=m Aqueous extract from rhizoma notopterygii reduces contact sensitivity by inhibiting lymphocyte migration via down-regulating metalloproteinase activity. ongoing research,unassigned 1,0 3.4.24.77 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15652769&form=6&db=m Aqueous extract from aerial parts of Artemisia vestita, a traditional Tibetan medicine, reduces contact sensitivity in mice by down-regulating the activation, adhesion and metalloproteinase production of T lymphocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24278051&form=6&db=m Serum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients. diagnostic usage,unassigned 1,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8614290&form=6&db=m Serum type III, IV collagens and TIMP in patients with type II diabetes mellitus. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15821833&form=6&db=m Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16626376&form=6&db=m In vitro evaluation of virulence attributes of Candida spp. isolated from patients affected by diabetes mellitus. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809308&form=6&db=m ADAMTS13 and von Willebrand factor concentrations in patients with diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228717&form=6&db=m TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22355395&form=6&db=m Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. causal interaction,unassigned 3,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23636268&form=6&db=m Expression of tissue inhibitor of metalloprotease 3 is reduced in ischemic but not neuropathic ulcers from patients with type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23678392&form=6&db=m The expression of a nitric oxide derivative, tissue inhibitors of metalloproteinase-3, and tissue inhibitors of metalloproteinase-4 in chronic periodontitis with type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26500845&form=6&db=m TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice. unassigned - 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27208743&form=6&db=m Association between Von Willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-Dimer and cystatin C levels with retinopathy in type 1 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181741&form=6&db=m Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25848912&form=6&db=m Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26168189&form=6&db=m Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27208743&form=6&db=m Association between Von Willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-Dimer and cystatin C levels with retinopathy in type 1 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446168&form=6&db=m Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29395841&form=6&db=m Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534304&form=6&db=m Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. causal interaction,unassigned 4,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16023759&form=6&db=m Monocyte matrix and ADAM metalloproteinase expression in type 2 diabetes after aspirin therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17714581&form=6&db=m Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633828&form=6&db=m Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21984580&form=6&db=m Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228717&form=6&db=m TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22355395&form=6&db=m Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. causal interaction,unassigned 3,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23010875&form=6&db=m ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23636268&form=6&db=m Expression of tissue inhibitor of metalloprotease 3 is reduced in ischemic but not neuropathic ulcers from patients with type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23678392&form=6&db=m The expression of a nitric oxide derivative, tissue inhibitors of metalloproteinase-3, and tissue inhibitors of metalloproteinase-4 in chronic periodontitis with type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059320&form=6&db=m Insulin-Degrading Enzyme: A Link between Alzheimer's and Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25824442&form=6&db=m Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise. ongoing research,unassigned 1,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26025789&form=6&db=m A neglected modulator of insulin-degrading enzyme activity and conformation: The pH. causal interaction,unassigned 2,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26500845&form=6&db=m TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice. unassigned - 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28430139&form=6&db=m The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181741&form=6&db=m Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30305381&form=6&db=m Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme. causal interaction,unassigned 3,0 3.4.24.77 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32191993&form=6&db=m FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme. causal interaction,unassigned 3,0 3.4.24.77 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29739074&form=6&db=m Association of Polymorphism rs17576 of the Metalloproteinase 9 Gene with Gestational Diabetes in Euro-Brazilian Pregnant Women. causal interaction,unassigned 1,0 3.4.24.77 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30623540&form=6&db=m Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Diabetic Foot http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11796794&form=6&db=m The role of matrix metalloproteinases in wound healing. causal interaction,unassigned 4,0 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8721333&form=6&db=m Role of tissue inhibitors of metalloproteinase in diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10426384&form=6&db=m IGF-1 decreases collagen degradation in diabetic NOD mesangial cells: implications for diabetic nephropathy. causal interaction,unassigned 3,0 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16133184&form=6&db=m Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16159895&form=6&db=m Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17879211&form=6&db=m Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21228113&form=6&db=m Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. ongoing research,therapeutic application,unassigned 2,4,0 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22896043&form=6&db=m Loss of tissue inhibitor of metalloproteinase 3 (TIMP3) selectively exacerbates diabetic nephropathy. ongoing research,unassigned 1,0 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911616&form=6&db=m Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29134286&form=6&db=m Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice. causal interaction,unassigned 4,0 3.4.24.77 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23791966&form=6&db=m Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Digestive System Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655735&form=6&db=m Novel role of microRNA-126 in digestive system cancers: From bench to bedside. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7646457&form=6&db=m Diphtheria toxin endocytosis and membrane translocation are dependent on the intact membrane-anchored receptor (HB-EGF precursor): studies on the cell-associated receptor cleaved by a metalloprotease in phorbol-ester-treated cells. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17292392&form=6&db=m Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways. therapeutic application,unassigned 1,0 3.4.24.77 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17915215&form=6&db=m Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I. therapeutic application,unassigned 2,0 3.4.24.77 Disseminated Intravascular Coagulation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602118&form=6&db=m Cloning of a prothrombin activator-like metalloproteinase from the West African saw-scaled viper, Echis ocellatus. unassigned - 3.4.24.77 Disseminated Intravascular Coagulation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24238574&form=6&db=m The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661359&form=6&db=m Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. causal interaction,unassigned 3,0 3.4.24.77 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16606835&form=6&db=m Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. ongoing research,unassigned 3,0 3.4.24.77 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19544290&form=6&db=m ADAM12s as a first-trimester screening marker of trisomy. diagnostic usage,therapeutic application,unassigned 4,1,0 3.4.24.77 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29342922&form=6&db=m Can EGCG Alleviate Symptoms of Down Syndrome by Altering Proteolytic Activity? causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32189297&form=6&db=m Insect Defense Proteins and Peptides. ongoing research,unassigned 2,0 3.4.24.77 Drug Hypersensitivity Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152183&form=6&db=m DRESS syndrome and thrombotic thrombocytopaenic purpura: are they related? ongoing research,unassigned 1,0 3.4.24.77 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28534808&form=6&db=m Development towards Compact Nitrocellulose-Based Interferometric Biochips for Dry Eye MMP9 Label-Free In-Situ Diagnosis. unassigned - 3.4.24.77 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039509&form=6&db=m Evaluation of a novel dry eye model induced by oral administration of finasteride. ongoing research,unassigned 1,0 3.4.24.77 Dupuytren Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18762113&form=6&db=m Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Dupuytren Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19786408&form=6&db=m The role of an MMP inhibitor in the regulation of mechanical tension by Dupuytren's fibroblasts. ongoing research,unassigned 3,0 3.4.24.77 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19331801&form=6&db=m Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.24.77 Ecchymosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32511239&form=6&db=m The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Ectopia Lentis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28176809&form=6&db=m Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease. unassigned - 3.4.24.77 Ectopia Lentis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201140&form=6&db=m Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage. unassigned - 3.4.24.77 Ehlers-Danlos Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12646579&form=6&db=m Transforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase. unassigned - 3.4.24.77 Ehlers-Danlos Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16472131&form=6&db=m ADAMTS Proteinases: Potential Therapeutic Targets? causal interaction,unassigned 3,0 3.4.24.77 Ehlers-Danlos Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22815532&form=6&db=m Chronic treatment with a broad-spectrum metalloproteinase inhibitor, doxycycline, prevents the development of spontaneous aortic lesions in a mouse model of vascular ehlers-danlos syndrome. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334204&form=6&db=m Protective and causative killer Ig-like receptor (KIR) and metalloproteinase genetic patterns associated with Herpes simplex virus 1 (HSV-1) encephalitis occurrence. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989572&form=6&db=m Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. ongoing research,unassigned 4,0 3.4.24.77 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16472131&form=6&db=m ADAMTS Proteinases: Potential Therapeutic Targets? causal interaction,unassigned 3,0 3.4.24.77 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19267908&form=6&db=m Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.24.77 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989572&form=6&db=m Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. ongoing research,unassigned 4,0 3.4.24.77 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19267908&form=6&db=m Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.24.77 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10472357&form=6&db=m Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage I and II endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10932976&form=6&db=m The association of transforming growth factor-beta 1 with myometrial invasion of endometrial carcinomas through effects on matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12487935&form=6&db=m [Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631221&form=6&db=m Effects of hepatocyte growth factor on the expression of matrix metalloproteinases and their tissue inhibitors during the endometrial cancer invasion in a three-dimensional coculture. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16142384&form=6&db=m Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase-7 and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22783422&form=6&db=m microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964525&form=6&db=m Matrix metalloproteinase (MMP)-2 and MMP-9 Expression in Tumor Infiltrating CD3 Lymphocytes From Women With Endometrial Cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205572&form=6&db=m MicroRNA-200b is overexpressed in endometrial adenocarcinomas and enhances MMP2 activity by downregulating TIMP2 in human endometrial cancer cell line HEC-1A cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29523216&form=6&db=m MiR-148b functions as a tumor suppressor by targeting endoplasmic reticulum metallo protease 1 in human endometrial cancer cells. ongoing research,unassigned 4,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31782329&form=6&db=m The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34187214&form=6&db=m Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Endometrial Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9066735&form=6&db=m Pulmonary metastatic lesion of endolymphatic stromal myosis expresses metastasis-related genes but not invasion-related matrix type metalloproteinase. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12372462&form=6&db=m Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts. causal interaction,unassigned 2,0 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15452706&form=6&db=m Eutopic endometrium and peritoneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2, -3 and -11, and of tissue inhibitor metalloproteinases-1 and -2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16635325&form=6&db=m [Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 mRNA in endometriosis] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609243&form=6&db=m Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18722604&form=6&db=m Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609072&form=6&db=m Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22053095&form=6&db=m TIMP1 Contributes to Ovarian Anomalies in Both an MMP-Dependent and -Independent Manner in a Rat Model. ongoing research,unassigned 2,0 3.4.24.77 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29530558&form=6&db=m [New medical treatments for painful endometriosis: CNGOF-HAS Endometriosis Guidelines]. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436691&form=6&db=m [Metalloproteinase activity in myocardium of rats exposed to endotoxin and its inhibition with doxycycline] ongoing research,unassigned 2,0 3.4.24.77 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10498596&form=6&db=m The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia. ongoing research,unassigned 4,0 3.4.24.77 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14501953&form=6&db=m Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15543933&form=6&db=m Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479965&form=6&db=m [The activity of components of system of matrix metalloproteinase and tissue inhibitors of metalloproteinase on different stages of chronic cardiac failure]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Enteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15178550&form=6&db=m Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis. ongoing research,unassigned 3,0 3.4.24.77 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716553&form=6&db=m Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Epidermolysis Bullosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6315831&form=6&db=m Generalized dominant epidermolysis bullosa simplex: decreased activity of a gelatinolytic protease in cultured fibroblasts as a phenotypic marker. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Epilepsies, Partial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577757&form=6&db=m Tetanus neurotoxin-induced epilepsy in mouse visual cortex. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19627981&form=6&db=m Different circulating metalloproteinases profiles in women with migraine with and without aura. diagnostic usage,unassigned 1,0 3.4.24.77 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24219907&form=6&db=m Oxidative stress, metalloproteinase and LDH in children with intractable and non-intractable epilepsy as reflected in salivary analysis. causal interaction,unassigned 4,0 3.4.24.77 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30075790&form=6&db=m Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 3.4.24.77 Epilepsy, Rolandic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718938&form=6&db=m Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. unassigned - 3.4.24.77 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11019938&form=6&db=m A full-UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19205380&form=6&db=m [Transforming growth factor beta, metalloproteinase 2 and its tissue inhibitor 2 in the serum from patients with early and late boreliosis] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 3.4.24.77 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032991&form=6&db=m Effects of the aminophenol analogue p-Dodecylaminophenol on mouse skin. therapeutic application,unassigned 1,0 3.4.24.77 Escherichia coli Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30190327&form=6&db=m Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces. ongoing research,unassigned 2,0 3.4.24.77 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626453&form=6&db=m Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26863569&form=6&db=m ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3. therapeutic application,unassigned 1,0 3.4.24.77 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18186556&form=6&db=m Methylation of TIMP3 in esophageal squamous cell carcinoma. ongoing research,unassigned 3,0 3.4.24.77 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776700&form=6&db=m Elevated levels of serum metalloproteinase 9 in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551050&form=6&db=m Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. causal interaction,unassigned 2,0 3.4.24.77 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23551625&form=6&db=m Immunohistochemical analysis on potential new molecular targets for esophageal cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25966212&form=6&db=m Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194665&form=6&db=m Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance. unassigned - 3.4.24.77 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19339995&form=6&db=m Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Exfoliation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15510480&form=6&db=m [Loss of heterozygosity at microsatellite marker localised near the metalloproteinase gene in patients with PEX syndrome] diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Exfoliation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24498922&form=6&db=m Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 3.4.24.77 Exotropia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31421016&form=6&db=m MMPs, TIMPs and BMP-4 in medial rectus muscle obtained from intermittent exotropia patients and their clinical correlations. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.77 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12766045&form=6&db=m Identification of differentially expressed genes in keratoconus epithelium analyzed on microarrays. causal interaction,unassigned 1,0 3.4.24.77 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28176809&form=6&db=m Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease. unassigned - 3.4.24.77 Familial Hypophosphatemic Rickets http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12791601&form=6&db=m FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. ongoing research,unassigned 1,0 3.4.24.77 Familial Hypophosphatemic Rickets http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15015068&form=6&db=m The enigma of hyperparathyroidism in hypophosphatemic rickets. unassigned - 3.4.24.77 Familial Primary Pulmonary Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863640&form=6&db=m Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 3.4.24.77 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172192&form=6&db=m Steatotic liver allografts up-regulate UCP-2 expression and suffer necrosis in rats. ongoing research,unassigned 4,0 3.4.24.77 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27373162&form=6&db=m A Role for Timp3 in Microbiota-Driven Hepatic Steatosis and Metabolic Dysfunction. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751722&form=6&db=m Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29912573&form=6&db=m Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Fetal Alcohol Spectrum Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32890773&form=6&db=m In utero alcohol exposure exacerbates endothelial protease activity from pial microvessels and impairs GABA interneuron positioning. causal interaction,unassigned 1,0 3.4.24.77 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21512165&form=6&db=m Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27159841&form=6&db=m Role of ADAMTS5 in Unexplained Fetal Growth Restriction (FGR). causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 3.4.24.77 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33549483&form=6&db=m Perigestational alcohol consumption induces altered early placentation and organogenic embryo growth restriction by disruption of trophoblast angiogenic factors. causal interaction,unassigned 3,0 3.4.24.77 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521441&form=6&db=m Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850251&form=6&db=m Transforming growth factor-beta suppresses the invasiveness of human fibrosarcoma cells in vitro by increasing expression of tissue inhibitor of metalloprotease. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2009533&form=6&db=m Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551898&form=6&db=m SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040211&form=6&db=m Type IV collagenase activity of a primary HSV-2-induced hamster fibrosarcoma and its in vivo metastases and in vitro clones. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6329972&form=6&db=m A fibrosarcoma model derived from mouse embryo cells: growth properties and secretion of collagenase and metalloproteinase inhibitor (TIMP) by tumour cell lines. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8422709&form=6&db=m Repression of stromelysin metalloprotease expression in rat fibrosarcoma cells by dimethylsulfoxide. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8530350&form=6&db=m Release of gelatinase A (matrix metalloproteinase 2) induced by photolysis of caged phosphatidic acid in HT 1080 metastatic fibrosarcoma cells. ongoing research,unassigned 2,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527751&form=6&db=m Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. unassigned - 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16386243&form=6&db=m Matrix metalloproteinase 2 secretion in WEHI 164 fibrosarcoma cells is nitric oxide-related and modified by morphine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497804&form=6&db=m Janus kinase 2 influences growth hormone receptor metalloproteolysis. ongoing research,unassigned 4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17121913&form=6&db=m Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17895241&form=6&db=m Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22595522&form=6&db=m Filamin A controls matrix metalloprotease activity and regulates cell invasion in human fibrosarcoma cells. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806820&form=6&db=m Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Furunculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23811350&form=6&db=m Innate and adaptive immune responses of Arctic charr (Salvelinus alpinus, L.) during infection with Aeromonas salmonicida subsp. achromogenes and the effect of the AsaP1 toxin. therapeutic application,unassigned 2,0 3.4.24.77 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22621753&form=6&db=m Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3298612&form=6&db=m Production of metalloproteinase in gastric tissue with acetic acid-induced ulcer or taurocholic acid-induced gastritis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20333791&form=6&db=m Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23901237&form=6&db=m Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21448147&form=6&db=m Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease. unassigned - 3.4.24.77 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31264989&form=6&db=m Expression of metalloproteinase-9 in patients with mild and severe forms of gastroesophageal reflux disease. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7951846&form=6&db=m Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19569245&form=6&db=m Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Gestational Trophoblastic Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912288&form=6&db=m Reduced expression of tissue inhibitor of metalloproteinase (TIMP)-2 in gestational trophoblastic diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 3.4.24.77 Gestational Trophoblastic Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24786121&form=6&db=m Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases. ongoing research,unassigned 2,0 3.4.24.77 Giant Cell Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843867&form=6&db=m Elevated levels of 92-kd type IV collagenase (matrix metalloproteinase 9) in giant cell arteritis. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Giant Cell Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12456779&form=6&db=m The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Giant Cell Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251041&form=6&db=m [Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone] diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27139570&form=6&db=m Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases. ongoing research,unassigned 3,0 3.4.24.77 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28598286&form=6&db=m Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30384155&form=6&db=m Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis. diagnostic usage,unassigned 3,0 3.4.24.77 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24498922&form=6&db=m Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 3.4.24.77 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342670&form=6&db=m Metalloproteinase 9 and TIMP-1 expression in retina and optic nerve in absolute angle closure glaucoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26956170&form=6&db=m Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28176809&form=6&db=m Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease. unassigned - 3.4.24.77 Glaucoma, Angle-Closure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342670&form=6&db=m Metalloproteinase 9 and TIMP-1 expression in retina and optic nerve in absolute angle closure glaucoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24498922&form=6&db=m Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 3.4.24.77 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28176809&form=6&db=m Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease. unassigned - 3.4.24.77 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34424262&form=6&db=m Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10. ongoing research,unassigned 1,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3198688&form=6&db=m Glioblastoma infiltration into central nervous system tissue in vitro: involvement of a metalloprotease. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8033133&form=6&db=m Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells. ongoing research,unassigned 4,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9426071&form=6&db=m Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10963898&form=6&db=m Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells. ongoing research,unassigned 4,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12712007&form=6&db=m Advances in molecular therapies in patients with brain tumors. therapeutic application,unassigned 4,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026328&form=6&db=m Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. ongoing research,unassigned 3,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16003758&form=6&db=m Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20413683&form=6&db=m An Extensive Invasive Intracranial Human Glioblastoma Xenograft Model. Role of High Level Matrix Metalloproteinase 9. ongoing research,unassigned 2,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25825051&form=6&db=m The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. causal interaction,unassigned 2,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713642&form=6&db=m Differential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927111&form=6&db=m Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway. therapeutic application,unassigned 3,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190936&form=6&db=m MiR-145 inhibits the epithelial-to-mesenchymal transition via targeting ADAM19 in human glioblastoma. ongoing research,unassigned 4,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29267965&form=6&db=m ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion. unassigned - 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142630&form=6&db=m Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival. diagnostic usage,unassigned 3,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033611&form=6&db=m Extracellular vesicles originating from glioblastoma cells increase metalloproteinase release by astrocytes: the role of CD147 (EMMPRIN) and ionizing radiation. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32074974&form=6&db=m Treatment with Gold Nanoparticles Using Cudrania tricuspidata Root Extract Induced Downregulation of MMP-2/-9 and PLD1 and Inhibited the Invasiveness of Human U87 Glioblastoma Cells. causal interaction,unassigned 3,0 3.4.24.77 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513131&form=6&db=m Modeling invasion patterns in the glioblastoma battlefield. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1321608&form=6&db=m Invasion of brain tissue by primary glioma: evidence for the involvement of urokinase-type plasminogen activator as an activator of type IV collagenase. diagnostic usage,unassigned 2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2064306&form=6&db=m A metalloproteinase, capable of destroying cultured brain tissue isolated from rat glioma cells. ongoing research,unassigned 4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156617&form=6&db=m Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells. ongoing research,unassigned 1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2241953&form=6&db=m Isolation and characterization of a metalloproteinase secreted by rat glioma cells in serum-free culture. ongoing research,unassigned 4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3555773&form=6&db=m Inhibition of growth and induction of differentiation in a malignant human glioma cell line by normal leptomeningeal extracellular matrix proteins. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8542596&form=6&db=m Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8871536&form=6&db=m Glioma invasion in vitro: regulation by matrix metalloprotease-2 and protein kinase C. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9409814&form=6&db=m Differential activity of bcl-2 and ICE enzyme family protease inhibitors on Fas and puromycin-induced apoptosis of glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9426071&form=6&db=m Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9708803&form=6&db=m Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721888&form=6&db=m Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9862565&form=6&db=m A metalloprotease activity from C6 glioma cells inactivates the myelin-associated neurite growth inhibitors and can be neutralized by antibodies. ongoing research,unassigned 2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9922462&form=6&db=m Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10801887&form=6&db=m Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. unassigned - 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10895974&form=6&db=m Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11716069&form=6&db=m Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12493117&form=6&db=m Anti-invasive effect of an anti-matrix metalloproteinase agent in a murine brain slice model using the serial monitoring of green fluorescent protein-labeled glioma cells. ongoing research,unassigned 4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622136&form=6&db=m Tracking cell invasion of human glioma cells and suppression by anti-matrix metalloproteinase agent in rodent brain-slice model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12712007&form=6&db=m Advances in molecular therapies in patients with brain tumors. therapeutic application,unassigned 4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604227&form=6&db=m Apoptotic induction by BE16627B on human malignant glioma cell lines by an anti-matrix metalloproteinase agent. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15113477&form=6&db=m Inhibition of glioma angiogenesis and invasion by SI-27, an anti-matrix metalloproteinase agent in a rat brain tumor model. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743799&form=6&db=m Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16033774&form=6&db=m The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16580779&form=6&db=m Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids. therapeutic application,unassigned 1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636750&form=6&db=m Randomized, double-blind, placebo-controlled trial of marimastat in glioblastoma multiforme patients following surgery and irradiation. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178873&form=6&db=m Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12. diagnostic usage,therapeutic application,unassigned 1,4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332917&form=6&db=m Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18802741&form=6&db=m Inflammatory cytokine modulation of matrix metalloproteinase expression and invasiveness of glioma cells in a 3-dimensional collagen matrix. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19617536&form=6&db=m Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21046310&form=6&db=m Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21289335&form=6&db=m Ionizing radiation affects epidermal growth factor receptor signalling and metalloproteinase secretion in glioma cells. ongoing research,unassigned 4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324352&form=6&db=m Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21983884&form=6&db=m Overexpression of a disintegrin and metalloprotease 8 in human gliomas is implicated in tumor progression and prognosis. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22162832&form=6&db=m Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23212305&form=6&db=m L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23242773&form=6&db=m pEGFP-N1-mediated BmK CT expression suppresses the migration of glioma. ongoing research,unassigned 2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23630058&form=6&db=m Integration of microfluidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23707077&form=6&db=m Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24014382&form=6&db=m Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24156018&form=6&db=m Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323769&form=6&db=m Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24752463&form=6&db=m Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline. causal interaction,unassigned 3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25127032&form=6&db=m Glioma-derived ADAM10 induces regulatory B cells to suppress CD8+ T cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25286828&form=6&db=m Combination of lithium chloride and pEGFP-N1-BmK CT effectively decreases proliferation and migration of C6 glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29131255&form=6&db=m The correlation between the expression of ADAM17, EGFR and Ki-67 in malignant gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30368528&form=6&db=m IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma. causal interaction,unassigned 1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816477&form=6&db=m Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells. therapeutic application,unassigned 1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31701492&form=6&db=m Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811456&form=6&db=m Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33987357&form=6&db=m Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514093&form=6&db=m Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712219&form=6&db=m Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9496737&form=6&db=m Serial alterations of glomerular matrix-degrading metalloproteinase activity in anti-thymocyte-induced glomerulonephritis in rats. ongoing research,unassigned 4,0 3.4.24.77 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11096152&form=6&db=m Circulating levels of matrix metalloproteinases MMP-3 and MMP-2 in renal transplant recipients with chronic transplant nephropathy. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12900822&form=6&db=m Doxycycline decreases proteinuria in glomerulonephritis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18355876&form=6&db=m Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta. ongoing research,unassigned 2,0 3.4.24.77 Glomerulonephritis, IGA http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917786&form=6&db=m The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix. causal interaction,unassigned 1,0 3.4.24.77 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613533&form=6&db=m Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712219&form=6&db=m Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Glomerulosclerosis, Focal Segmental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712219&form=6&db=m Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Glomerulosclerosis, Focal Segmental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8719546&form=6&db=m Glomerular metalloprotease activity modulates the development of focal segmental glomerulosclerosis. therapeutic application,unassigned 2,0 3.4.24.77 Glomerulosclerosis, Focal Segmental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21720805&form=6&db=m Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16294222&form=6&db=m Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. causal interaction,unassigned 4,0 3.4.24.77 Gnathostomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15888296&form=6&db=m Gnathostoma binucleatum: excretion-secretion antigen analysis obtained from advanced third-stage larvae in in vitro culture. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.77 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9226153&form=6&db=m A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.24.77 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10233398&form=6&db=m A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.77 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10414917&form=6&db=m A metalloproteinase inhibitor prevents acute graft-versus-host disease in mice after bone marrow transplantation. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.77 Graft vs Host Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953977&form=6&db=m A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation. therapeutic application,unassigned 4,0 3.4.24.77 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8254040&form=6&db=m Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8551095&form=6&db=m [Mechanism of the radiolucence around the implant after hip prosthetic replacement] unassigned - 3.4.24.77 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18705699&form=6&db=m Mycobacteria-induced granuloma necrosis depends on IRF-1. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27034654&form=6&db=m Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2 3.4.24.77 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28527839&form=6&db=m Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 3.4.24.77 Hajdu-Cheney Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756348&form=6&db=m Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene. causal interaction,unassigned 2,0 3.4.24.77 Hajdu-Cheney Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922033&form=6&db=m Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome. diagnostic usage,unassigned 3,0 3.4.24.77 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102660&form=6&db=m Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.24.77 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509148&form=6&db=m Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. causal interaction,unassigned 4,0 3.4.24.77 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21986939&form=6&db=m A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25704985&form=6&db=m Dynamic contrast-enhanced MRI evaluates the early response of human head and neck tumor xenografts following anti-EMMPRIN therapy with cisplatin or irradiation. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27804311&form=6&db=m Systemic matrix metalloproteinase-8 response in chronic tonsillitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32699732&form=6&db=m Thrombotic Thrombocytopenic Purpura: Revisiting a Miss and an Inevitable Consequence. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Heart Defects, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23558858&form=6&db=m Plasmatic ADAMTS-13 metalloprotease and von Willebrand factor in children with cyanotic congenital heart disease. unassigned - 3.4.24.77 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15780796&form=6&db=m Cardiac remodeling and failure From molecules to man (Part II). unassigned - 3.4.24.77 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21760969&form=6&db=m Synergism between arrhythmia and hyperhomo-cysteinemia in structural heart disease. causal interaction,unassigned 1,0 3.4.24.77 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24244825&form=6&db=m Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 3.4.24.77 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28987763&form=6&db=m Endogenous osteopontin induces myocardial CCL5 and MMP-2 activation that contributes to inflammation and cardiac remodeling in a mouse model of chronic Chagas heart disease. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050751&form=6&db=m Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. unassigned - 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2143536&form=6&db=m Elevation of plasma atrial natriuretic peptide in rats with chronic heart failure by SCH 39370, a neutral metalloendopeptidase inhibitor. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7853175&form=6&db=m Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10773235&form=6&db=m Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12045381&form=6&db=m Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12864774&form=6&db=m Metalloproteinases 2 and 9 are increased in plasma of patients with heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15230033&form=6&db=m [The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure] causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16436497&form=6&db=m Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure. therapeutic application,unassigned 3,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178594&form=6&db=m Arrhythmia and neuronal/endothelial myocyte uncoupling in hyperhomocysteinemia. unassigned - 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456279&form=6&db=m Selective MMP-12 inhibitors: WO-2008057254. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20453389&form=6&db=m Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21760969&form=6&db=m Synergism between arrhythmia and hyperhomo-cysteinemia in structural heart disease. causal interaction,unassigned 1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479965&form=6&db=m [The activity of components of system of matrix metalloproteinase and tissue inhibitors of metalloproteinase on different stages of chronic cardiac failure]. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595230&form=6&db=m Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25944577&form=6&db=m Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients. causal interaction,unassigned 3,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28266892&form=6&db=m Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis. therapeutic application,unassigned 1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29930267&form=6&db=m Relationship of polymorphisms in the tissue inhibitor of metalloproteinase (TIMP)-1 and -2 genes with chronic heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30371322&form=6&db=m Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts. causal interaction,unassigned 4,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31345101&form=6&db=m Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32643898&form=6&db=m Can the expression of the metalloproteinase 9 gene and its inhibitor be considered as markers of heart failure? causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.4.24.77 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33064567&form=6&db=m MMP9 inhibition increases autophagic flux in chronic heart failure. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Heart Rupture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21243368&form=6&db=m Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab. ongoing research,unassigned 4,0 3.4.24.77 Heart Septal Defects, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14673146&form=6&db=m Essential role for ADAM19 in cardiovascular morphogenesis. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 HELLP Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969811&form=6&db=m Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.77 HELLP Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19663680&form=6&db=m Placental expression of proteases and their inhibitors in patients with HELLP syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 HELLP Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20558950&form=6&db=m Pregnancy-associated thrombotic thrombocytopenic purpura with anti-centromere antibody-positive Raynaud's Syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Hemangioma, Cavernous, Central Nervous System http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17043747&form=6&db=m Expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) in cerebral cavernous malformations: immunohistochemical analysis of MMP-2, -9 and TIMP-2. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566207&form=6&db=m Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Hemochromatosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10424282&form=6&db=m Elevated serum type IV collagen: a sensitive indicator of the presence of cirrhosis in haemochromatosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676770&form=6&db=m Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. unassigned - 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421153&form=6&db=m Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. diagnostic usage,unassigned 4,0 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17058049&form=6&db=m Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology. unassigned - 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22879435&form=6&db=m Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23899959&form=6&db=m Immature platelet fraction can help adjust therapy in refractory thrombotic microangiopathic hemolytic anemia cases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073552&form=6&db=m Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis. diagnostic usage,therapeutic application,unassigned 4,2,0 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669560&form=6&db=m Clinical experience in treatment of thrombotic thrombocytopenic purpura--hemolytic uremic syndrome with 28 patients. therapeutic application,unassigned 4,0 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25377323&form=6&db=m Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. unassigned - 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27752001&form=6&db=m Acute kidney injury in Hemiscorpius lepturus scorpion stung children: Risk factors and clinical features. causal interaction,unassigned 4,0 3.4.24.77 Hemolytic-Uremic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33552303&form=6&db=m [Thrombotic microangiopathy]. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Hemophilia B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24169902&form=6&db=m Development of novel treatment options for patients with haemophilia. ongoing research,therapeutic application,unassigned 1,4,0 3.4.24.77 Hemorrhagic Fever with Renal Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33925451&form=6&db=m Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia. diagnostic usage,unassigned 1,0 3.4.24.77 Hemorrhagic Fever, Ebola http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21734050&form=6&db=m Functional Genomics Reveals the Induction of Inflammatory Response and Metalloproteinase Gene Expression during Lethal Ebola Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Hemostatic Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26026608&form=6&db=m Moojenactivase, a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom, activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes. causal interaction,unassigned 3,0 3.4.24.77 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1339165&form=6&db=m [Hepatic fibrosis and its serum markers] diagnostic usage,unassigned 1,0 3.4.24.77 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228126&form=6&db=m Serum collagenase activity in patients with chronic liver disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11345837&form=6&db=m Expression of decorin, transforming growth factor-beta 1, tissue inhibitor metalloproteinase 1 and 2, and type IV collagenases in chronic hepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33814981&form=6&db=m Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver Inflammation Models and Enhances Cytokine Release In Vitro. causal interaction,unassigned 4,0 3.4.24.77 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344903&form=6&db=m Activation of the envelope proteins by a metalloproteinase enables attachment and entry of the hepatitis B virus into T-lymphocyte. ongoing research,unassigned 2,0 3.4.24.77 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799863&form=6&db=m Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation. unassigned - 3.4.24.77 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7499785&form=6&db=m Serum markers for connective tissue turnover in patients with chronic hepatitis B and chronic hepatitis C: a comparative analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793509&form=6&db=m Plasma Level of ADAMTS13 or IL-12 as an Indicator of HBeAg Seroconversion in Chronic Hepatitis B Patients Undergoing m-ETV Treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11281552&form=6&db=m Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22530132&form=6&db=m Markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis C. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.24.77 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25430937&form=6&db=m ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29120572&form=6&db=m Gene polymorphisms of Interleukin 1? and Metalloproteinase 3 in Hepatitis C Infected Patients and Hepatocellular Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.24.77 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7499785&form=6&db=m Serum markers for connective tissue turnover in patients with chronic hepatitis B and chronic hepatitis C: a comparative analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16425392&form=6&db=m Effect of pegylated interferon alpha 2b plus ribavirin treatment on plasma transforming growth factor-beta1, metalloproteinase-1, and tissue metalloproteinase inhibitor-1 in patients with chronic hepatitis C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699498&form=6&db=m Effects of interferon plus ribavirin treatment on NF-kappaB, TGF-beta1, and metalloproteinase activity in chronic hepatitis C. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.77 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26406331&form=6&db=m Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Hepatitis, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188171&form=6&db=m Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.77 Hepatitis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22323541&form=6&db=m Stromal TIMP3 Regulates Liver Lymphocyte Populations and Provides Protection against Th1 T Cell-Driven Autoimmune Hepatitis. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228126&form=6&db=m Serum collagenase activity in patients with chronic liver disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11281552&form=6&db=m Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309715&form=6&db=m Effect of lamivudine treatment on plasma levels of transforming growth factor beta1, tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20195229&form=6&db=m Altered pattern of circulating matrix metalloproteinases -2,- 9 and tissue inhibitor of metalloproteinase -2 in patients with HCV-related chronic hepatitis. Relationship to histological features. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040211&form=6&db=m Type IV collagenase activity of a primary HSV-2-induced hamster fibrosarcoma and its in vivo metastases and in vitro clones. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393846&form=6&db=m Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.4.24.77 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23598435&form=6&db=m Ultrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334204&form=6&db=m Protective and causative killer Ig-like receptor (KIR) and metalloproteinase genetic patterns associated with Herpes simplex virus 1 (HSV-1) encephalitis occurrence. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19106482&form=6&db=m Importance of the Porcine ADAM3 Disintegrin Domain in Sperm-Egg Interaction. unassigned - 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22357757&form=6&db=m Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility. unassigned - 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22458710&form=6&db=m Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10). therapeutic application,unassigned 1,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25205729&form=6&db=m Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B. therapeutic application,unassigned 1,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28137755&form=6&db=m Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion. therapeutic application,unassigned 1,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28911209&form=6&db=m Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30679641&form=6&db=m Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases. causal interaction,unassigned 2,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31077549&form=6&db=m A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth. unassigned - 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118423&form=6&db=m Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis. therapeutic application,unassigned 1,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33008835&form=6&db=m Novel proteomic profiling of epididymal extracellular vesicles in the domestic cat reveals proteins related to sequential sperm maturation with differences observed between normospermic and teratospermic individuals. unassigned - 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33333173&form=6&db=m Cellular and molecular modification of egg envelope hardening in fertilization. causal interaction,unassigned 1,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33723300&form=6&db=m Blast-induced temporal alterations in blood-brain barrier properties in a rodent model. causal interaction,unassigned 1,0 3.4.24.77 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34320465&form=6&db=m The E-modulus of the oocyte is a non-destructive measure of zona pellucida hardening. unassigned - 3.4.24.77 Histiocytoma, Benign Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8543309&form=6&db=m Expression of the tissue metalloproteinase inhibitors TIMP-1 and TIMP-2 in malignant fibrous histiocytomas and dermatofibromas as studied by in situ hybridization and immunohistochemistry. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Histiocytoma, Malignant Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8543309&form=6&db=m Expression of the tissue metalloproteinase inhibitors TIMP-1 and TIMP-2 in malignant fibrous histiocytomas and dermatofibromas as studied by in situ hybridization and immunohistochemistry. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Histiocytoma, Malignant Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521441&form=6&db=m Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24086377&form=6&db=m Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Hookworm Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15837211&form=6&db=m Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum. unassigned - 3.4.24.77 HTLV-I Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7613621&form=6&db=m Induction of MMP9 (92 kDa gelatinase) activity and expression of tissue inhibitor of metalloproteinase-2 mRNA (TIMP-2) in primitive neuroectodermal cells infected with retrovirus HTLV-I. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2874190&form=6&db=m Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.24.77 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33601422&form=6&db=m ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. therapeutic application,unassigned 1,0 3.4.24.77 Hyaline Membrane Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376362&form=6&db=m Gelatinase activities in the airways of premature infants and development of bronchopulmonary dysplasia. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Hydatidiform Mole http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11775947&form=6&db=m [Prediction of malignant transformation of hydatidiform mole by mRNA determination of matrix metalloproteinases and tissue inhibitor of metalloproteinases] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 3.4.24.77 Hydatidiform Mole http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912288&form=6&db=m Reduced expression of tissue inhibitor of metalloproteinase (TIMP)-2 in gestational trophoblastic diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 3.4.24.77 Hydatidiform Mole http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830297&form=6&db=m Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8967345&form=6&db=m Expression of subunits of the metalloendopeptidase meprin in renal cortex in experimental hydronephrosis. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16920226&form=6&db=m Effect of the C-terminus of murine S100A9 protein on experimental nociception. unassigned - 3.4.24.77 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616564&form=6&db=m GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. therapeutic application,unassigned 2,0 3.4.24.77 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19805319&form=6&db=m Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. therapeutic application,unassigned 1,0 3.4.24.77 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26072684&form=6&db=m Inflammatory mediators involved in the paw edema and hyperalgesia induced by Batroxase, a metalloproteinase isolated from Bothrops atrox snake venom. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15629898&form=6&db=m Leptin induces ovulation in GnRH-deficient mice. causal interaction,unassigned 2,0 3.4.24.77 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16225464&form=6&db=m Review article: diabetes and atherosclerosis--running on a common road. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19605949&form=6&db=m CCN2 protein is an announcing marker for cardiac remodeling following STZ-induced moderate hyperglycemia in mice. causal interaction,unassigned 4,0 3.4.24.77 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21471190&form=6&db=m Distinct actions of ETA selective versus combined ETA/ETB receptor antagonists in early diabetic kidney disease. diagnostic usage,unassigned 3,0 3.4.24.77 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20938722&form=6&db=m Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats. causal interaction,unassigned 4,0 3.4.24.77 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693634&form=6&db=m CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.4.24.77 Hyperprolactinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8699421&form=6&db=m Regulation of granulosa cell-derived ovarian metalloproteinase inhibitor(s) by prolactin. therapeutic application,unassigned 3,0 3.4.24.77 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19665773&form=6&db=m Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.77 Hypersensitivity, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288453&form=6&db=m Macrophage-migration inhibitory factor: role in inflammatory diseases and graft rejection. causal interaction,unassigned 1,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1725358&form=6&db=m Phosphoramidon blocks the pressor activity of big endothelin[1-39] and lowers blood pressure in spontaneously hypertensive rats. unassigned - 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641322&form=6&db=m Pharmacokinetic-pharmacodynamic (PK-PD) modeling for a new antihypertensive agent (neutral metalloendopeptidase inhibitor SCH 42354) in patients with mild to moderate hypertension. causal interaction,therapeutic application,unassigned 2,3,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9544878&form=6&db=m Effects of omapatrilat in low, normal, and high renin experimental hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779100&form=6&db=m Endothelin-1 inactivating peptidase in the human kidney and urine. causal interaction,unassigned 4,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11054505&form=6&db=m Matrix metalloproteinase-9 and tissue inhibitor metalloproteinase-1 levels in essential hypertension. Relationship to left ventricular mass and anti-hypertensive therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553025&form=6&db=m Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16 and bradykinin B2 receptors do not play important roles in renal wrap hypertension in rabbits. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15261932&form=6&db=m Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863640&form=6&db=m Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18054360&form=6&db=m Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18260972&form=6&db=m [Metalloproteinase activity of the blood in patients with arterial hypertension with paroxysmal form of atrial fibrillation.] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19254213&form=6&db=m [Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension] causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19339995&form=6&db=m Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19893495&form=6&db=m Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood. causal interaction,unassigned 3,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21228113&form=6&db=m Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. ongoing research,therapeutic application,unassigned 2,4,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23149063&form=6&db=m Porto-pulmonary hypertension exacerbated by platelet transfusion in a patient with ADAMTS13 deficiency. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23185005&form=6&db=m Targeted disruption of Adamts16 gene in a rat genetic model of hypertension. causal interaction,unassigned 3,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24077247&form=6&db=m Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice. ongoing research,therapeutic application,unassigned 3,2,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24871629&form=6&db=m Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1? causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25308714&form=6&db=m Metalloproteinase Inhibition Protects against Reductions in Circulating Adrenomedullin during Lead-induced Acute Hypertension. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25934767&form=6&db=m Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy. causal interaction,unassigned 4,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26254330&form=6&db=m ?-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26500845&form=6&db=m TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice. unassigned - 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412873&form=6&db=m Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27417395&form=6&db=m Resistant Hypertension: Is There a Pathophysiologic Role for the Metalloproteinase System? unassigned - 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27993561&form=6&db=m Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30946986&form=6&db=m Oxidative stress and vascular stiffness in hypertension: A renewed interest for antioxidant therapies? causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Hypertension, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28679995&form=6&db=m Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756423&form=6&db=m ADAMTS13 deficiency, despite well-compensated liver functions in patients with noncirrhotic portal hypertension. causal interaction,unassigned 4,0 3.4.24.77 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26775093&form=6&db=m Plasma ADAMTS-13 protein is not associated with portal hypertension or hemodynamic changes in patients with cirrhosis. causal interaction,unassigned 3,0 3.4.24.77 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28980147&form=6&db=m ADAMTS13 missense variants associated with defective activity and secretion of ADAMTS13 in a patient with non-cirrhotic portal hypertension. causal interaction,unassigned 4,0 3.4.24.77 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33369998&form=6&db=m Altered von Willebrand Factor and ADAMTS13 Levels in Children With Cirrhosis and Extrahepatic Portal Hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.4.24.77 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18477480&form=6&db=m Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21769110&form=6&db=m Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.4.24.77 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327101&form=6&db=m Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665462&form=6&db=m Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats. causal interaction,unassigned 3,0 3.4.24.77 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31556812&form=6&db=m ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Hypoglossal Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311987&form=6&db=m A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons. causal interaction,unassigned 3,0 3.4.24.77 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30187439&form=6&db=m The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9116149&form=6&db=m Neonatal hypothyroidism alters the pattern of prostatic growth and differentiation, as well as plasminogen activator and metalloprotease expression, in the rat. causal interaction,unassigned 3,0 3.4.24.77 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979817&form=6&db=m [Change of matrix metalloproteinase-1 and matrix metalloproteinase-7 in serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and sarcoidosis]. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171287&form=6&db=m Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.4.24.77 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052708&form=6&db=m Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161886&form=6&db=m ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950707&form=6&db=m Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain. therapeutic application,unassigned 1,0 3.4.24.77 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1348597&form=6&db=m Identification of a surface metalloproteinase on 13 species of Leishmania isolated from humans, Crithidia fasciculata, and Herpetomonas samuelpessoai. diagnostic usage,unassigned 3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429449&form=6&db=m Cloning of a metalloprotease gene involved in the virulence mechanism of Vibrio anguillarum. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1808459&form=6&db=m Vascular permeability enhancement by Vibrio mimicus protease and the mechanisms of action. causal interaction,unassigned 3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2206203&form=6&db=m Comparative pathogenicity of a wild-type strain and respiratory mutants of Candida albicans in mice. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7594783&form=6&db=m [Detection of Bacteroides fragilis enterotoxin from extraintestinal clinical isolates of B. fragilis group organisms] causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7808483&form=6&db=m Genetic rescue of surface metalloproteinase (gp63)-deficiency in Leishmania amazonensis variants increases their infection of macrophages at the early phase. causal interaction,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8105105&form=6&db=m CD13 (human aminopeptidase N) mediates human cytomegalovirus infection. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8568270&form=6&db=m HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8660569&form=6&db=m Synthetic peptide substrates for a conductimetric assay of Pseudomonas aeruginosa elastase. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858909&form=6&db=m Enhancin, the granulosis virus protein that facilitates nucleopolyhedrovirus (NPV) infections, is a metalloprotease. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945541&form=6&db=m Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis. causal interaction,unassigned 4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9024202&form=6&db=m Trichuris suis: thiol protease activity from adult worms. causal interaction,unassigned 3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9139920&form=6&db=m Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9308319&form=6&db=m Mouse skin damage caused by a recombinant extracellular metalloprotease from Vibrio vulnificus and by V. vulnificus infection. ongoing research,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10481742&form=6&db=m Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10603371&form=6&db=m Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: modulation of gp63 level in promastigotes and their infection of macrophages in vitro. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10871436&form=6&db=m Detection of elastase from Pseudomonas aeruginosa in sputum and its potential role in epithelial cell permeability. causal interaction,unassigned 3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10871477&form=6&db=m Matrilysin (matrix metalloproteinase 7) in parturition, premature rupture of membranes, and intrauterine infection. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10920315&form=6&db=m Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11119504&form=6&db=m Legionella pneumophila major acid phosphatase and its role in intracellular infection. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11163095&form=6&db=m Soluble donor HLA class I and beta 2m-free heavy chain in serum of lung transplant recipients: steady-state levels and increases in patients with recurrent CMV infection, acute rejection episodes, and poor outcome. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369868&form=6&db=m Increased proteolytic activity and matrix metalloprotease expression in lungs during infection by porcine reproductive and respiratory syndrome virus. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566980&form=6&db=m Measuring virulence factor expression by the pathogenic bacterium Photorhabdus luminescens in culture and during insect infection. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11856233&form=6&db=m An archival case of clinically significant infection in a surgical patient by enterotoxigenic Bacteroides fragilis: PCR amplification of the metalloprotease enterotoxin gene from non-viable lyophilizates. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867235&form=6&db=m Cloning and sequence analysis of a novel metalloprotease gene from Vibrio parahaemolyticus 04. causal interaction,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393846&form=6&db=m Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12661139&form=6&db=m Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12672541&form=6&db=m Infection of human astrocytoma cells with simian-human immunodeficiency virus results in up-regulation of gene expression and altered growth properties. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500495&form=6&db=m gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587282&form=6&db=m Meprin proteolytic complexes at the cell surface and in extracellular spaces. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734190&form=6&db=m Evaluation of immunogenicity and protective efficacy of a Microsporum canis metalloprotease subunit vaccine in guinea pigs. ongoing research,therapeutic application,unassigned 1,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15275152&form=6&db=m A role for matrix metalloproteinases in the pathology and attenuation of Theileria annulata infections. causal interaction,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15618147&form=6&db=m Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15749117&form=6&db=m CD13/aminopeptidase N and murine cytomegalovirus infection. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15784459&form=6&db=m CMV-infected allogeneic endothelial cells initiate responder and bystander donor HLA class I release via the metalloproteinase cleavage pathway. ongoing research,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15866474&form=6&db=m Identification of an astacin-like metallo-proteinase transcript from the infective larvae of Strongyloides stercoralis. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15893126&form=6&db=m Enhancing anti-inflammatory cytokine IL-10 may be beneficial for acute coronary syndrome. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085838&form=6&db=m Identification and characterization of putative virulence genes and gene clusters in Aeromonas hydrophila PPD134/91. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16958802&form=6&db=m Vibrio vulnificus infection and metalloprotease. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17005805&form=6&db=m Effect of PEX, a Noncatalytic Metalloproteinase Fragment with Integrin-Binding Activity, on Experimental Chlamydophila pneumoniae Infection. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17347015&form=6&db=m Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17923522&form=6&db=m Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18026209&form=6&db=m Expression and characterization of a metalloprotease from a Vibrio parahaemolyticus isolate. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032516&form=6&db=m Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18083880&form=6&db=m The type II secretion system of Legionella pneumophila elaborates two aminopeptidases, as well as a metalloprotease that contributes to differential infection among protozoan hosts. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18187780&form=6&db=m Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18253117&form=6&db=m Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617643&form=6&db=m VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19133011&form=6&db=m Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19149697&form=6&db=m Management of severe abdominal infections. therapeutic application,unassigned 3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19246759&form=6&db=m A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformis. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19247439&form=6&db=m Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346305&form=6&db=m The propeptide of the metalloprotease of Listeria monocytogenes controls compartmentalization of the zymogen during intracellular infection. ongoing research,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19553339&form=6&db=m Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19572270&form=6&db=m Rhinovirus upregulates matrix metalloproteinase-2, matrix metalloproteinase-9, and vascular endothelial growth factor expression in nasal polyp fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19783786&form=6&db=m Human Rhinovirus Infection Upregulates MMP-9 Production in Airway Epithelial Cells via NF-{kappa}B. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19958583&form=6&db=m Collagen-based wound dressing for doxycycline delivery: in-vivo evaluation in an infected excisional wound model in rats. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20002577&form=6&db=m A recombinant metalloprotease antigen of Vibrio vulnificus elicits protective antibodies in a murine model. therapeutic application,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20012275&form=6&db=m A Large-Scale Epidemiological Study to Identify Bacteria Pathogenic to Pacific Oyster Crassostrea gigas and Correlation Between Virulence and Metalloprotease-like Activity. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21073892&form=6&db=m Molecular responses of Ostrea edulis haemocytes to an in vitro infection with Bonamia ostreae. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106748&form=6&db=m Role of the host cell's unfolded protein response in arenavirus infection. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21226722&form=6&db=m Cocktail of gp63 and Hsp70 induces protection against Leishmania donovani in BALB/c mice. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21330433&form=6&db=m Paenibacillus larvae metalloprotease production during the infection of honeybee larvae. ongoing research,unassigned 3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21444693&form=6&db=m Novel Inhibitors Of The Pseudomonas aeruginosa Virulence Factor Pseudolysin/LasB: A Potential Therapeutic Approach For The Attenuation Of Virulence Mechanisms In Pseudomonal Infection. causal interaction,unassigned 4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21471301&form=6&db=m Relief from Zmp1-mediated arrest of phagosome maturation is associated with facilitated presentation and enhanced immunogenicity of mycobacterial antigens. ongoing research,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21501359&form=6&db=m Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection. diagnostic usage,unassigned 3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21812888&form=6&db=m The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22270239&form=6&db=m Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. therapeutic application,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22483117&form=6&db=m Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22530132&form=6&db=m Markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis C. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22565637&form=6&db=m How Helicobacter pylori infection controls gastric acid secretion. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22747600&form=6&db=m Bacillus anthracis' Lethal Toxin Induces Broad Transcriptional Responses in Human Peripheral Monocytes. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23181168&form=6&db=m 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23768487&form=6&db=m Staphylococcus aureus osteomyelitis: bad to the bone. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23776165&form=6&db=m The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23803463&form=6&db=m Fatal hemolytic uremic syndrome associated with day care surgery and anaesthesia: a case report. diagnostic usage,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23990436&form=6&db=m Ancylostoma ceylanicum metalloprotease 6 DNA vaccination induces partial protection against hookworm challenge infection. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23990803&form=6&db=m Combining quantitative genetic footprinting and trait enrichment analysis to identify fitness determinants of a bacterial pathogen. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24214942&form=6&db=m Modulation of the Bacillus anthracis secretome by the immune inhibitor A1 protease. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24973455&form=6&db=m Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA. causal interaction,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25182493&form=6&db=m Molecular characterization of protease activity in Serratia sp. strain SCBI and its importance in cytotoxicity and virulence. ongoing research,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25253612&form=6&db=m The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna. causal interaction,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25262802&form=6&db=m Anthrax lethal factor inhibitors as potential countermeasure of the infection. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25384557&form=6&db=m A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25430937&form=6&db=m ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25899393&form=6&db=m Edwardsiella tarda Sip1: A serum-induced zinc metalloprotease that is essential to serum resistance and host infection. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27147619&form=6&db=m Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus ?-toxin action. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27736644&form=6&db=m Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27840223&form=6&db=m Characterization of a metalloprotease involved in Vibrio splendidus infection in the sea cucumber, Apostichopus japonicus. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28266892&form=6&db=m Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28304138&form=6&db=m Rapid and efficient one-step purification of a serralysin family protease by using a p-aminobenzamidine-modified affinity medium. causal interaction,unassigned 4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28399190&form=6&db=m Expression of the insect metalloproteinase inhibitor IMPI in the fat body of Galleria mellonella exposed to infection with Beauveria bassiana. causal interaction,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594571&form=6&db=m ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28608214&form=6&db=m Use of Zymography in Trypanosomiasis Studies. therapeutic application,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29233714&form=6&db=m Bi-layered nanocomposite bandages for controlling microbial infections and overproduction of matrix metalloproteinase activity. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29475600&form=6&db=m Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30190327&form=6&db=m Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces. ongoing research,unassigned 2,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30267305&form=6&db=m Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30372490&form=6&db=m A metalloprotease produced by larval Schistosoma mansoni facilitates infection establishment and maintenance in the snail host by interfering with immune cell function. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30408181&form=6&db=m The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30723129&form=6&db=m A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32179532&form=6&db=m In Vitro and In Vivo Characterization of Potent Antileishmanial Methionine Aminopeptidase-1 Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32251295&form=6&db=m Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans. causal interaction,unassigned 1,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485089&form=6&db=m von Willebrand factor increases in experimental cerebral malaria but is not essential for late-stage pathogenesis in mice. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32567007&form=6&db=m Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-?? and ASK1 Pathways. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685457&form=6&db=m Detection of Metalloproteases and Cysteine Proteases RNA Transcripts of Leishmania (Leishmania) infantum in Ear Edge Skin of Naturally Infected Dogs. unassigned - 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32979835&form=6&db=m The Pseudomonas aeruginosa protease LasB directly activates IL-1?. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33247098&form=6&db=m Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34392581&form=6&db=m Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.24.77 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17156190&form=6&db=m Could the defects in the endometrial extracellular matrix during the implantation be a cause for impaired fertility? causal interaction,unassigned 3,0 3.4.24.77 Infertility, Female http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32946206&form=6&db=m A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9122163&form=6&db=m Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16344067&form=6&db=m Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17589947&form=6&db=m Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19262505&form=6&db=m MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24378596&form=6&db=m Infliximab restores the dysfunctional matrix remodeling protein and growth factor gene expression in patients with inflammatory bowel disease. causal interaction,unassigned 4,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765701&form=6&db=m Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694039&form=6&db=m Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin ? Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31054542&form=6&db=m Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31184526&form=6&db=m An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A. unassigned - 3.4.24.77 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33946534&form=6&db=m Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metalloprotease 1 Expression by Mucosal Stromal Cells and Colorectal Cancer Development in Inflammatory Bowel Disease. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10481742&form=6&db=m Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.24.77 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22496659&form=6&db=m Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27736644&form=6&db=m Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594571&form=6&db=m ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity. unassigned - 3.4.24.77 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34523355&form=6&db=m ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16225464&form=6&db=m Review article: diabetes and atherosclerosis--running on a common road. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19027012&form=6&db=m Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19581416&form=6&db=m TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633828&form=6&db=m Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20589975&form=6&db=m Pattern of expression of inflammatory markers in adipose tissue of untreated hypertensive patients. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22028447&form=6&db=m Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22471305&form=6&db=m Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels. causal interaction,unassigned 3,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26312858&form=6&db=m The role of metalloproteinases and their tissue inhibitors in adipose tissue remodelling and whole-body lipid distribution: a cross-sectional clinical study. ongoing research,unassigned 4,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26359121&form=6&db=m Inflammatory and metabolic markers and short-time outcome in patients with acute ischemic stroke in relation to TOAST subtypes. diagnostic usage,unassigned 2,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29658577&form=6&db=m Interleukin 29 activates expression of tissue inhibitor of metalloproteinase 1 in macrophages via toll?like receptor 2. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32820223&form=6&db=m Markers of remodeling in subcutaneous adipose tissue are strongly associated with overweight and insulin sensitivity in healthy non-obese men. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16741450&form=6&db=m Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17343002&form=6&db=m [Study on yiqi huayu bushen recipe and its disassembled recipes in regulating mRNA expression of collagens and metabolic enzymes in extracellular matrix of cervical disc] ongoing research,unassigned 4,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21311395&form=6&db=m Mechanical destabilisation induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. unassigned - 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949132&form=6&db=m TNF-? and IL-1? promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. causal interaction,unassigned 3,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179320&form=6&db=m Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. unassigned - 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23500174&form=6&db=m Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24579357&form=6&db=m [Effect of electroacupuncture intervention on expression of extracellular matrix collagen and metabolic enzymes]. ongoing research,unassigned 3,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25826898&form=6&db=m [Expression of p16INK4a in nucleus pulposus and its effect on degenerated intervertebral discs]. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26924131&form=6&db=m Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model. causal interaction,unassigned 2,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26974833&form=6&db=m Resistin Promotes Intervertebral Disc Degeneration by Up-Regulation of ADAMTS-5 Through p38 MAPK Signaling Pathway. causal interaction,unassigned 2,0 3.4.24.77 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31056878&form=6&db=m [Electroacupuncture down-regulates expression of ADAMTS-4 of intervertebral disc in rats with lumbar intervertebral disc degeneration]. causal interaction,unassigned 1,0 3.4.24.77 Intestinal Volvulus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17347015&form=6&db=m Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.77 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605322&form=6&db=m Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. causal interaction,unassigned 3,0 3.4.24.77 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17494658&form=6&db=m mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays. ongoing research,therapeutic application,unassigned 2,4,0 3.4.24.77 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20487632&form=6&db=m Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381111&form=6&db=m Differential expression levels of collagen 1A2, tissue inhibitor of metalloproteinase 4, and cathepsin B in intracranial aneurysms. ongoing research,unassigned 2,0 3.4.24.77 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723034&form=6&db=m Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Intracranial Hemorrhages http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796276&form=6&db=m The rs9509 polymorphism of MMP-9 is associated with risk of hemorrhage in brain arteriovenous malformations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.24.77 Intracranial Hemorrhages http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23052179&form=6&db=m Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Intracranial Hemorrhages http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723034&form=6&db=m Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25430937&form=6&db=m ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27095094&form=6&db=m Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis. ongoing research,unassigned 4,0 3.4.24.77 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201033&form=6&db=m Involvement of MMPs in delayed neuronal death after global ischemia. ongoing research,unassigned 2,0 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740200&form=6&db=m Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20627731&form=6&db=m Matrix metalloproteinase-9 contributes to the increase of tau protein in serum during acute ischemic stroke. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727681&form=6&db=m Association between ADAM17 Promoter Polymorphisms and Ischemic Stroke in a Chinese Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26692927&form=6&db=m Heat shock protein 90 inhibition by 17-Dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27135051&form=6&db=m Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis. causal interaction,unassigned 1,0 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453088&form=6&db=m Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29618156&form=6&db=m ADAMTS-13 Activity Predicts Outcome in Acute Ischaemic Stroke Patients Undergoing Endovascular Treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29875068&form=6&db=m MMP-9 and/or TIMP as predictors of ischaemic stroke in patients with symptomatic and asymptomatic atherosclerotic stenosis of carotid artery treated by stenting or endarterectomy - A review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31585956&form=6&db=m Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events. unassigned - 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32849241&form=6&db=m The Value of ADAMTS13 in Predicting Clinical Outcomes in Patients With Acute Ischemic Stroke Receiving Thrombolysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.4.24.77 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34099834&form=6&db=m Combination treatment with U0126 and rt-PA prevents adverse effects of the delayed rt-PA treatment after acute ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Jaw Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24974940&form=6&db=m Collagenase-3 expression in periapical lesions: an immunohistochemical study. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Job Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21872914&form=6&db=m Plasma metalloproteinase levels are dysregulated in signal transducer and activator of transcription 3 mutated hyper-IgE syndrome. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1377121&form=6&db=m Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts. therapeutic application,unassigned 1,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168825&form=6&db=m The effect of recombinant tumor necrosis factor-alpha on superoxide and metalloproteinase production by synovial cells and chondrocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756348&form=6&db=m Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene. causal interaction,unassigned 2,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684582&form=6&db=m Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22186957&form=6&db=m Fluorescence resonance energy transfer assay for high-throughput screening of ADAMTS1 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23716507&form=6&db=m Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31369701&form=6&db=m Novel functions of inactive rhomboid proteins in immunity and disease. causal interaction,unassigned 3,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32003758&form=6&db=m Nesfatin-1 suppresses interleukin-1?-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. causal interaction,unassigned 3,0 3.4.24.77 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32349389&form=6&db=m Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1?-induced Primary Human Articular Chondrocytes. causal interaction,unassigned 4,0 3.4.24.77 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27855376&form=6&db=m Growth Differentiation Factor-9 Promotes Fibroblast Proliferation and Migration in Keloids through the Smad2/3 Pathway. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1480049&form=6&db=m The effect of a synthetic metalloproteinase inhibitor on corneal ulceration in alkali burns and pseudomonas keratitis. unassigned - 3.4.24.77 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23181168&form=6&db=m 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27034404&form=6&db=m JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity. ongoing research,unassigned 4,0 3.4.24.77 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347749&form=6&db=m Tissue Inhibitor of Metalloproteinase (TIMP) Peptidomimetic as an Adjunctive Therapy for Infectious Keratitis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8156782&form=6&db=m Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metalloproteinase ratio. causal interaction,unassigned 3,0 3.4.24.77 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8359032&form=6&db=m Keratoconus corneas: increased gelatinolytic activity appears after modification of inhibitors. ongoing research,unassigned 4,0 3.4.24.77 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17276265&form=6&db=m Histopathological findings after intracorneal ring segment implantation in keratoconic human corneas. unassigned - 3.4.24.77 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21976959&form=6&db=m Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus. ongoing research,unassigned 3,0 3.4.24.77 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15699592&form=6&db=m Decreased expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in the kidneys of hereditary nephrotic (ICGN) mice. causal interaction,unassigned 3,0 3.4.24.77 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21136910&form=6&db=m The glomerular proteome in a model of chronic kidney disease. causal interaction,unassigned 1,0 3.4.24.77 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226724&form=6&db=m ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33879883&form=6&db=m Key metalloproteinase-mediated pathways in the kidney. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3083678&form=6&db=m Detection of a metalloproteinase in patients with acute and chronic renal failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9407462&form=6&db=m Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779100&form=6&db=m Endothelin-1 inactivating peptidase in the human kidney and urine. causal interaction,unassigned 4,0 3.4.24.77 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29134286&form=6&db=m Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice. causal interaction,unassigned 4,0 3.4.24.77 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29255356&form=6&db=m Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441135&form=6&db=m MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.24.77 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923216&form=6&db=m Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo. causal interaction,unassigned 2,0 3.4.24.77 Laminopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16364671&form=6&db=m Laminopathies: multisystem dystrophy syndromes. causal interaction,unassigned 3,0 3.4.24.77 Laminopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29696758&form=6&db=m MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies. causal interaction,unassigned 1,0 3.4.24.77 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9710383&form=6&db=m Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.24.77 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21786164&form=6&db=m Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1?, interleukin-1?, interleukin-8 levels and fibroblast activation. ongoing research,unassigned 2,0 3.4.24.77 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22798012&form=6&db=m Potential role of metalloproteinase inhibitors from radiation?sterilized amnion dressings in the healing of venous leg ulcers. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Legionnaires' Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527507&form=6&db=m Demonstration of the intracellular production of tissue-destructive protease by Legionella pneumophila multiplying within guinea-pig and human alveolar macrophages. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Legionnaires' Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33491325&form=6&db=m Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation. unassigned - 3.4.24.77 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20933117&form=6&db=m Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678627&form=6&db=m Mapping human T cell epitopes in leishmania gp63. Identification of cross-reactive and species-specific epitopes. unassigned - 3.4.24.77 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999607&form=6&db=m Antigen genes for molecular epidemiology of leishmaniasis: polymorphism of cysteine proteinase B and surface metalloprotease glycoprotein 63 in the Leishmania donovani complex. unassigned - 3.4.24.77 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20008541&form=6&db=m High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2297760&form=6&db=m A latent Mr 94,000 gelatin-degrading metalloprotease induced during differentiation of HL-60 promyelocytic leukemia cells: a member of the collagenase family of enzymes. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551898&form=6&db=m SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7828672&form=6&db=m Leukemic cells (HL-60) produce a novel extracellular matrix-degrading proteinase that is not inhibited by tissue inhibitors of matrix metalloproteinases (TIMPs). ongoing research,unassigned 2,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8120026&form=6&db=m Soluble beta 2-microglobulin-free class I heavy chains are released from the surface of activated and leukemia cells by a metalloprotease. ongoing research,unassigned 2,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8556714&form=6&db=m Tumor necrosis factor alpha and lymphotoxin stimulate human myeloblastic leukemia cell (ML-1) invasion through a reconstituted basement membrane (Matrigel) with concomitant induction of 92 kDa gelatinase secretion. ongoing research,unassigned 4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11863416&form=6&db=m Envelope-targeted retrovirus vectors transduce melanoma xenografts but not spleen or liver. ongoing research,unassigned 4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12729479&form=6&db=m CD10 expression is useful in the diagnosis of follicular carcinoma and follicular variant of papillary thyroid carcinoma. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197802&form=6&db=m DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352705&form=6&db=m Anti-inflammatory activity in vitro and in vivo of the protein farnesyltransferase inhibitor tipifarnib. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618731&form=6&db=m Id1 transcription inhibitor-matrix metalloproteinase 9 axis enhances invasiveness of the breakpoint cluster region/abelson tyrosine kinase-transformed leukemia cells. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806998&form=6&db=m High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. ongoing research,unassigned 3,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890764&form=6&db=m Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci. causal interaction,unassigned 2,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790751&form=6&db=m Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19159951&form=6&db=m Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20138666&form=6&db=m The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21223734&form=6&db=m [Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22268520&form=6&db=m Protein profiling of anastomosed facial nerve treated with mesenchymal stromal cells. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23484726&form=6&db=m [Research progress on mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia]. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530665&form=6&db=m Purification of nasulysin-1: A new toxin from Porthidium nasutum snake venom that specifically induces apoptosis in leukemia cell model through caspase-3 and apoptosis-inducing factor activation. therapeutic application,unassigned 4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594571&form=6&db=m ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity. unassigned - 3.4.24.77 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31569263&form=6&db=m Morus alba Stem Extract Suppresses Matrix Metalloproteinases (MMP)-1, MMP-9, and Tissue Inhibitors of Metalloproteinase (TIMP)-1 Expression via Inhibition of I?B? Degradation Induced by Porphyromonas gingivalis LPS Signal in THP-1 Cells. ongoing research,unassigned 4,0 3.4.24.77 Leukemia, Hairy Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17309824&form=6&db=m Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells. therapeutic application,unassigned 2,0 3.4.24.77 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240053&form=6&db=m Plasma matrix metalloprotease 9 correlates with blood lymphocytosis, leukemic cell invasiveness, and prognosis in B-cell chronic lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Leukemia, Monocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20138666&form=6&db=m The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Leukemia, Monocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21223734&form=6&db=m [Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062258&form=6&db=m The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia. ongoing research,unassigned 3,0 3.4.24.77 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566207&form=6&db=m Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Leukemia, Plasma Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197802&form=6&db=m DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17823911&form=6&db=m AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies. ongoing research,unassigned 2,0 3.4.24.77 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790751&form=6&db=m Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31942139&form=6&db=m Immunohistochemical and clinical significance of matrix metalloproteinase-2 and its inhibitor in oral lichen planus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 3.4.24.77 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15998779&form=6&db=m A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia. causal interaction,unassigned 3,0 3.4.24.77 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587406&form=6&db=m Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. therapeutic application,unassigned 1,0 3.4.24.77 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19162222&form=6&db=m Lipodystrophies: Disorders of adipose tissue biology. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19494770&form=6&db=m Inherited lipodystrophies and hypertriglyceridemia. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631028&form=6&db=m A novel syndrome of mandibular hypoplasia, deafness, and progeroid features associated with lipodystrophy, undescended testes, and male hypogonadism. causal interaction,unassigned 3,0 3.4.24.77 Lipodystrophy, Congenital Generalized http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12913070&form=6&db=m Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. unassigned - 3.4.24.77 Lipodystrophy, Congenital Generalized http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19162222&form=6&db=m Lipodystrophies: Disorders of adipose tissue biology. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Lipodystrophy, Congenital Generalized http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19494770&form=6&db=m Inherited lipodystrophies and hypertriglyceridemia. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Lipoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33406387&form=6&db=m CD10 (neprilysin) expression: a potential adjunct in the distinction of hibernoma from morphologic mimics. unassigned - 3.4.24.77 Listeriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19897755&form=6&db=m Galleria mellonella as a model system for studying Listeria pathogenesis. unassigned - 3.4.24.77 Liver Abscess, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25452550&form=6&db=m Immunization with the Entamoeba histolytica surface metalloprotease EhMSP-1 protects hamsters from amebic liver abscess. therapeutic application,unassigned 1,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9691091&form=6&db=m Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. therapeutic application,unassigned 1,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10847486&form=6&db=m Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats. causal interaction,unassigned 1,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14515040&form=6&db=m [Clinical usefulness of plasma activities of gelatinase (matrix metalloproteinase-2 and 9) in chronic liver disease] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15521018&form=6&db=m The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623375&form=6&db=m [The relationship of serum metalloproteinase with the severity of liver fibrosis and inflammation.] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15860571&form=6&db=m A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16689760&form=6&db=m Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995994&form=6&db=m [Effect of rosiglitazone on metalloproteinase tissue inhibitor-1 in CCl4-induced liver fibrosis in rats.] ongoing research,unassigned 3,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17522433&form=6&db=m Generation and optimization of human antagonistic antibodies against TIMP-1 as potential therapeutic agents in fibrotic diseases. ongoing research,therapeutic application,unassigned 2,4,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19787203&form=6&db=m Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno-associated viruses carrying siRNAs in hepatic stellate cells. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20587139&form=6&db=m Transplantation of Human Wharton's Jelly-Derived Stem Cells Alleviates Chemically Induced Liver Fibrosis in Rats. unassigned - 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140473&form=6&db=m Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. ongoing research,unassigned 2,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21300026&form=6&db=m Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation. causal interaction,unassigned 1,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22303721&form=6&db=m [Regulatory effects of Qinggan Huoxue Recipe on matrix metalloproteinases of alcoholic liver fibrosis rats]. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23460364&form=6&db=m C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice. ongoing research,unassigned 3,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23755201&form=6&db=m Tumor necrosis factor-? promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23918878&form=6&db=m Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-?1/Smad signalling, MMPs and TIMPs. ongoing research,unassigned 4,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24763901&form=6&db=m IL-20 and IL-20R1 antibodies protect against liver fibrosis. causal interaction,unassigned 3,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25100997&form=6&db=m The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies. causal interaction,unassigned 4,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25430937&form=6&db=m ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25568138&form=6&db=m Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice. causal interaction,unassigned 4,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26775093&form=6&db=m Plasma ADAMTS-13 protein is not associated with portal hypertension or hemodynamic changes in patients with cirrhosis. causal interaction,unassigned 3,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27247426&form=6&db=m Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis. therapeutic application,unassigned 1,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28839277&form=6&db=m Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-?1/Smads and PI3K/Akt pathways. unassigned - 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31139312&form=6&db=m ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628797&form=6&db=m Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188171&form=6&db=m Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11750276&form=6&db=m Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081167&form=6&db=m Plasma transforming growth factor beta1, metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 in acute viral hepatitis type B. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18490073&form=6&db=m Hepatic expression of A disintegrin and metalloproteinase (ADAM) and ADAMs with thrombospondin motives (ADAM-TS) enzymes in patients with chronic liver diseases. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19766963&form=6&db=m Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22530132&form=6&db=m Markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis C. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436140&form=6&db=m Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases. therapeutic application,unassigned 1,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26075890&form=6&db=m Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28410274&form=6&db=m Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. therapeutic application,unassigned 1,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751722&form=6&db=m Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29912573&form=6&db=m Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33774926&form=6&db=m Targeting von Willebrand factor in liver diseases: A novel therapeutic strategy? causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8986196&form=6&db=m Serum markers for hepatic fibrosis in alcoholic liver disease: which is the best marker, type III procollagen, type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase? diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139919&form=6&db=m Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265769&form=6&db=m Transcriptome analysis of PPAR? target genes reveals the involvement of lysyl oxidase in human placental cytotrophoblast invasion. diagnostic usage,unassigned 1,0 3.4.24.77 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751722&form=6&db=m Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2187705&form=6&db=m Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12634787&form=6&db=m Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23902466&form=6&db=m Polymorphisms of the ADAM33 gene and Chronic Obstructive Pulmonary Disease Risk: a Meta-Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.4.24.77 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357020&form=6&db=m Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.4.24.77 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32772139&form=6&db=m Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. causal interaction,unassigned 3,0 3.4.24.77 Lung Diseases, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15887294&form=6&db=m c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. ongoing research,unassigned 4,0 3.4.24.77 Lung Diseases, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24815146&form=6&db=m Curcumin attenuates liver warm ischemia and reperfusion-induced combined restrictive and obstructive lung disease by reducing matrix metalloprotease 9 activity. therapeutic application,unassigned 1,0 3.4.24.77 Lung Diseases, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30759009&form=6&db=m Functional Studies of Single-Nucleotide Polymorphisms Suggest Heterogeneity in Chronic Obstructive Pulmonary Disease due to Susceptibility of Different Cell Types. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12219011&form=6&db=m Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12850461&form=6&db=m Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.4.24.77 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461845&form=6&db=m [Study on effect of dexamethasone on the expression of matrix metalloproteinase and its tissue inhibitors in hyperoxia-induced lung injury] causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.4.24.77 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947421&form=6&db=m Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19545667&form=6&db=m Matrix metalloprotease expressions in both reperfusion lung injury and oleic acid lung injury models and the protective effects of ilomastat. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25962375&form=6&db=m Hypertonic Saline (NaCl 7.5 %) Reduces LPS-Induced Acute Lung Injury in Rats. causal interaction,unassigned 1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322794&form=6&db=m Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837354&form=6&db=m Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells. ongoing research,unassigned 4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9213309&form=6&db=m Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer. therapeutic application,unassigned 4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10050880&form=6&db=m CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10430098&form=6&db=m Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10810441&form=6&db=m Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer--TIMP-1 as a prognostic marker. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10956415&form=6&db=m Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196170&form=6&db=m Aberrant promoter methylation of multiple genes in non-small cell lung cancers. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11410500&form=6&db=m Elevated serum levels of type I collagen degradation marker ICTP and tissue inhibitor of metalloproteinase (TIMP) 1 are associated with poor prognosis in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740999&form=6&db=m Angiogenesis inhibitors in the treatment of lung cancer. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242256&form=6&db=m AE-941 (AEterna). therapeutic application,unassigned 4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526122&form=6&db=m Serum tissue inhibitors of metalloproteinase-1 and -2 in patients with non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15832061&form=6&db=m Cerebral ischemic events in patients with advanced lung or prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15886272&form=6&db=m Changes in angiogenic growth factor levels after gefitinib treatment in non-small cell lung cancer. ongoing research,unassigned 3,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17074815&form=6&db=m Dual role of SnoN in mammalian tumorigenesis. causal interaction,unassigned 1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118669&form=6&db=m Video-assisted thoracic surgery lobectomy for lung cancer is associated with less immunochemokine disturbances than thoracotomy. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17874625&form=6&db=m [The serum concentration of metalloproteinase 9 and 2 in non-small cell lung cancer patients] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559520&form=6&db=m Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18710625&form=6&db=m [Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19094243&form=6&db=m Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723873&form=6&db=m CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20112342&form=6&db=m ADAM28 is a serological and histochemical marker for non-small-cell lung cancers. diagnostic usage,unassigned 1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20562912&form=6&db=m Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263792&form=6&db=m Differential expressions of matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22291012&form=6&db=m Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor associated dendritic cells by expressing HB-EGF. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22292754&form=6&db=m Differential Expressions Of Matrix Metalloproteinases, A Disintegrin And Metalloproteinases, And A Disintegrin And Metalloproteinases With Thrombospondin Motifs And Their Endogenous Inhibitors Among Histologic Subtypes Of Lung Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22354764&form=6&db=m Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. diagnostic usage,unassigned 3,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982189&form=6&db=m Loss of TIMP-3 Promotes Tumor Invasion via Elevated IL-6 Production and Predicts Poor Survival and Relapse in HPV-Infected Non-Small Cell Lung Cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319321&form=6&db=m Protective effects of ADAM8 against cisplatin-mediated apoptosis in non-small-cell lung cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23465389&form=6&db=m The relationship of metalloproteinase gene polymorphisms and lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25778452&form=6&db=m RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893726&form=6&db=m Combined RNAi targeting human Stat3 and ADAM9 as gene therapy for non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27090654&form=6&db=m Evaluation of Pregnancy-Associated Plasma Protein-A Levels in Patients with Chronic Obstructive Pulmonary Disease and Associations with Disease Severity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927148&form=6&db=m Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28942831&form=6&db=m Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29118335&form=6&db=m ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207990&form=6&db=m Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31196220&form=6&db=m Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31452742&form=6&db=m Cryptotanshinone inhibits lung cancer invasion via microRNA-133a/matrix metalloproteinase 14 regulation. unassigned - 3.4.24.77 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31945053&form=6&db=m The use of mixed collagen-Matrigel matrices of increasing complexity recapitulates the biphasic role of cell adhesion in cancer cell migration: ECM sensing, remodeling and forces at the leading edge of cancer invasion. ongoing research,unassigned 1,0 3.4.24.77 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23554033&form=6&db=m ADAMTS-13 metalloprotease abnormalities in systemic lupus erythematosus: is there a correlation with disease status? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.77 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26174315&form=6&db=m Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA2-Me-pro-ChTr possessing two different activities-trypsin-like and metalloprotease. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770692&form=6&db=m Increased expression of ADAMTS13 mRNA correlates with ischemic cerebrovascular disease in systemic lupus erythematosus patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27782255&form=6&db=m Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA1-Me-pro with two metalloprotease active centers. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31747459&form=6&db=m Systemic lupus erythematosus: possible localization of trypsin-like and metalloprotease active centers in the protein sequence of the monoclonal light chain (NGTA2-Me-pro-Tr). ongoing research,unassigned 4,0 3.4.24.77 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723234&form=6&db=m Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19090960&form=6&db=m Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20041189&form=6&db=m Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.4.24.77 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133703&form=6&db=m Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. ongoing research,unassigned 2,0 3.4.24.77 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31369701&form=6&db=m Novel functions of inactive rhomboid proteins in immunity and disease. causal interaction,unassigned 3,0 3.4.24.77 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767911&form=6&db=m Cloning of a salivary gland metalloprotease and characterization of gelatinase and fibrin(ogen)lytic activities in the saliva of the Lyme disease tick vector Ixodes scapularis. ongoing research,unassigned 1,0 3.4.24.77 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15618147&form=6&db=m Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19205380&form=6&db=m [Transforming growth factor beta, metalloproteinase 2 and its tissue inhibitor 2 in the serum from patients with early and late boreliosis] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 3.4.24.77 Lymphadenitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32028697&form=6&db=m Comment on "Fibroblasts in Nodular SclerosingClassical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury" Cancers 2019, 11, 1687. ongoing research,unassigned 4,0 3.4.24.77 Lymphangioleiomyomatosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21881731&form=6&db=m Doxycycline use in patients with lymphangioleiomyomatosis: safety and efficacy in metalloproteinase blockade. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486578&form=6&db=m The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169394&form=6&db=m Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma. ongoing research,unassigned 2,0 3.4.24.77 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413742&form=6&db=m Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20112342&form=6&db=m ADAM28 is a serological and histochemical marker for non-small-cell lung cancers. diagnostic usage,unassigned 1,0 3.4.24.77 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22354764&form=6&db=m Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. diagnostic usage,unassigned 3,0 3.4.24.77 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30504396&form=6&db=m Contribution of MMP2 Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan. causal interaction,unassigned 3,0 3.4.24.77 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240053&form=6&db=m Plasma matrix metalloprotease 9 correlates with blood lymphocytosis, leukemic cell invasiveness, and prognosis in B-cell chronic lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1421616&form=6&db=m Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645604&form=6&db=m Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas. unassigned - 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10477738&form=6&db=m Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11290537&form=6&db=m Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12729479&form=6&db=m CD10 expression is useful in the diagnosis of follicular carcinoma and follicular variant of papillary thyroid carcinoma. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239135&form=6&db=m Metalloproteinase inhibition augments antitumor efficacy of the anti-CD30 immunotoxin Ki-3(scFv)-ETA' against human lymphomas in vivo. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15356104&form=6&db=m Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16164124&form=6&db=m [Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study] ongoing research,unassigned 2,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17439836&form=6&db=m Expression of anaplastic lymphoma kinase, tyrosine-phosphorylated STAT3, and associated factors in pediatric anaplastic large cell lymphoma: A report from the children's oncology group. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19219072&form=6&db=m Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426775&form=6&db=m [Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.] diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22489798&form=6&db=m VEGF and MMP-9: biomarkers for canine lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917443&form=6&db=m Relevance of radiobiological concepts in radionuclide therapy of cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28586031&form=6&db=m Punicalagin suppresses the proliferation and invasion of cervical cancer cells through inhibition of the ?-catenin pathway. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132572&form=6&db=m Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31575107&form=6&db=m Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies. ongoing research,unassigned 1,0 3.4.24.77 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32737532&form=6&db=m Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. ongoing research,unassigned 3,0 3.4.24.77 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11290537&form=6&db=m Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426775&form=6&db=m [Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.] diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30144364&form=6&db=m Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection. unassigned - 3.4.24.77 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32309847&form=6&db=m MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3. diagnostic usage,unassigned 3,0 3.4.24.77 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32455798&form=6&db=m Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes. ongoing research,unassigned 1,0 3.4.24.77 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32737532&form=6&db=m Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. ongoing research,unassigned 3,0 3.4.24.77 Lymphoma, Large-Cell, Anaplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17439836&form=6&db=m Expression of anaplastic lymphoma kinase, tyrosine-phosphorylated STAT3, and associated factors in pediatric anaplastic large cell lymphoma: A report from the children's oncology group. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Lymphoma, Large-Cell, Immunoblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1421616&form=6&db=m Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.4.24.77 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917443&form=6&db=m Relevance of radiobiological concepts in radionuclide therapy of cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.24.77 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917443&form=6&db=m Relevance of radiobiological concepts in radionuclide therapy of cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10509665&form=6&db=m Age-dependent variation in metalloproteinase activity of isolated human Bruch's membrane and choroid. ongoing research,unassigned 3,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103944&form=6&db=m AG-3340 (Agouron Pharmaceuticals Inc). causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837541&form=6&db=m Tissue inhibitor of metalloproteinase-3 differentially binds to components of Bruch's membrane. causal interaction,unassigned 4,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20385819&form=6&db=m Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. causal interaction,unassigned 2,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23791966&form=6&db=m Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23841278&form=6&db=m [Prevention and treatment of age-related macular degeneration by extract of Fructus lycii and its constituents lutein/zeaxanthin: an in vive and in vitro experimental research]. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30288950&form=6&db=m Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy. causal interaction,unassigned 3,0 3.4.24.77 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907369&form=6&db=m Increased pro-MMP9 plasma levels are associated with neovascular age-related macular degeneration and with the risk allele of rs142450006 near MMP9. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27400127&form=6&db=m Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678927&form=6&db=m Metalloprotease activity in a small heat shock protein of the human malaria parasite Plasmodium vivax. ongoing research,unassigned 2,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11697726&form=6&db=m Computer modeling of small heat-shock metalloprotease of the human malaria parasite Plasmodium vivax. ongoing research,unassigned 2,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14676296&form=6&db=m Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule. unassigned - 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16168946&form=6&db=m Effect of metalloprotease inhibitors on invasion of red blood cell by Plasmodium falciparum. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17074076&form=6&db=m A role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast. therapeutic application,unassigned 1,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23176597&form=6&db=m Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24742203&form=6&db=m Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria. therapeutic application,unassigned 3,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25183733&form=6&db=m Functional characterization of Anopheles matrix metalloprotease 1 reveals its agonistic role during sporogonic development of malaria parasites. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32678064&form=6&db=m A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance. therapeutic application,unassigned 1,0 3.4.24.77 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18710562&form=6&db=m Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: role of IL-1beta and 15-HETE. causal interaction,unassigned 3,0 3.4.24.77 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22168261&form=6&db=m Association of ADAMTS13 polymorphism with cerebral malaria. causal interaction,unassigned 4,0 3.4.24.77 Marfan Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28067899&form=6&db=m Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943315&form=6&db=m Increase in milk metalloproteinase activity and vascular permeability in bovine endotoxin-induced and naturally occurring Escherichia coli mastitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8601622&form=6&db=m Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9708803&form=6&db=m Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11716074&form=6&db=m Medulloblastoma displays distinct regional matrix metalloprotease expression. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19847623&form=6&db=m The invasiveness of five medulloblastoma cell lines in collagen gels. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22959284&form=6&db=m Prognostic and clinical implication of a disintegrin and metalloprotease 8 expression in pediatric medulloblastoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316333&form=6&db=m Gelatinolytic metalloproteinase secretion patterns in ocular melanoma. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847357&form=6&db=m Recombinant interferon alpha and gamma modulate the invasive potential of human melanoma in vitro. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030444&form=6&db=m Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles. diagnostic usage,unassigned 1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3663169&form=6&db=m Purification and characterization of a connective-tissue-degrading metalloproteinase from the cytosol of metastatic melanoma cells. ongoing research,unassigned 4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8305739&form=6&db=m Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9622064&form=6&db=m Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9686582&form=6&db=m Human melanoma-reactive CD4+ and CD8+ CTL clones resist Fas ligand-induced apoptosis and use Fas/Fas ligand-independent mechanisms for tumor killing. unassigned - 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454257&form=6&db=m Anti-metastatic activity of curcumin and catechin. unassigned - 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667602&form=6&db=m A specific sequence of the noncollagenous domain of the alpha3(IV) chain of type IV collagen inhibits expression and activation of matrix metalloproteinases by tumor cells. unassigned - 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10769685&form=6&db=m Potentiated antitumor effects of interleukin 12 and matrix metalloproteinase inhibitor batimastat against B16F10 melanoma in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10877999&form=6&db=m Tandem duplication. A novel type of triplet repeat instability. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11863416&form=6&db=m Envelope-targeted retrovirus vectors transduce melanoma xenografts but not spleen or liver. ongoing research,unassigned 4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175610&form=6&db=m Inhibition of melanoma cells tumorigenicity by the snake venom toxin jararhagin. ongoing research,therapeutic application,unassigned 3,2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12198771&form=6&db=m Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009718&form=6&db=m Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15059909&form=6&db=m Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15205682&form=6&db=m CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression. unassigned - 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15292257&form=6&db=m Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen. ongoing research,unassigned 4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374996&form=6&db=m Autocrine secretion of Fas ligand shields tumor cells from Fas-mediated killing by cytotoxic lymphocytes. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337627&form=6&db=m Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion. ongoing research,unassigned 4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949178&form=6&db=m Melanoma cell-derived vascular endothelial growth factor induces endothelial tubulogenesis within fibrin gels by a metalloproteinase-mediated mechanism. unassigned - 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17012225&form=6&db=m Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. unassigned - 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160014&form=6&db=m Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18031543&form=6&db=m Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18419677&form=6&db=m Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18604945&form=6&db=m Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors. diagnostic usage,unassigned 3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18956140&form=6&db=m Artemisinin reduces human melanoma cell migration by down-regulating alphaVbeta3 integrin and reducing metalloproteinase 2 production. ongoing research,unassigned 2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147814&form=6&db=m The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19627587&form=6&db=m Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cells. causal interaction,unassigned 3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19826446&form=6&db=m Stromal collagenase in melanoma: a vascular connection. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19865098&form=6&db=m ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20886547&form=6&db=m Cytochrome P450 17 (CYP17) Is Involved in Endometrial Cancinogenesis Through Apoptosis and Invasion Pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20969766&form=6&db=m Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. causal interaction,unassigned 3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21047771&form=6&db=m Mutational and Functional Analysis Reveals ADAMTS18 Metalloproteinase as a Novel Driver in Melanoma. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21119930&form=6&db=m Variability in melanoma metalloproteinase expression profiling. ongoing research,unassigned 2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701781&form=6&db=m Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21876729&form=6&db=m PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23067222&form=6&db=m RNA-interference-mediated downregulation of Pin1 suppresses tumorigenicity of malignant melanoma A375 cells. causal interaction,unassigned 3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23342114&form=6&db=m Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23654233&form=6&db=m 1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335752&form=6&db=m Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24733393&form=6&db=m The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24788523&form=6&db=m A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284767&form=6&db=m Cilengitide downmodulates invasiveness and vasculogenic mimicry of neuropilin 1 expressing melanoma cells through the inhibition of ?v?5 integrin. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25839957&form=6&db=m Tissue inhibitor of metalloproteinase 2 inhibits activation of the ?-catenin signaling in melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25940796&form=6&db=m Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464684&form=6&db=m Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26991356&form=6&db=m The anti cancer activity of organotelluranes: potential role in integrin inactivation. ongoing research,unassigned 2,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27060463&form=6&db=m EMMPRIN/CD147 is an independent prognostic biomarker in cutaneous melanoma. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27096756&form=6&db=m Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27436149&form=6&db=m Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622031&form=6&db=m TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27748762&form=6&db=m Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells. causal interaction,unassigned 1,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553955&form=6&db=m Deletion of ADAM-9 in HGF/CDK4 mice impairs melanoma development and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890564&form=6&db=m Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31764436&form=6&db=m The alternatively spliced RECK transcript variant 3 is a predictor of poor survival for melanoma patients being upregulated in aggressive cell lines and modulating MMP gene expression in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32291412&form=6&db=m The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis. causal interaction,unassigned 4,0 3.4.24.77 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917849&form=6&db=m Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3198688&form=6&db=m Glioblastoma infiltration into central nervous system tissue in vitro: involvement of a metalloprotease. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10895974&form=6&db=m Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19922547&form=6&db=m Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene Is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas. therapeutic application,unassigned 1,0 3.4.24.77 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27438616&form=6&db=m The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.4.24.77 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28875568&form=6&db=m Gene Expression of Matrix Metalloproteinases and their Inhibitors (TIMPs) in Meningiomas of Dogs. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16640649&form=6&db=m Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18187780&form=6&db=m Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28806983&form=6&db=m Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.24.77 Meningitis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15578971&form=6&db=m Advances in adjuvant therapy against acute bacterial meningitis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Meningitis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16640649&form=6&db=m Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Meningitis, Pneumococcal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489958&form=6&db=m Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. therapeutic application,unassigned 1,0 3.4.24.77 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289878&form=6&db=m The interaction of tenascin-C with fibronectin modulates the migration and specific metalloprotease activity in human mesothelioma cell lines of different histotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 3.4.24.77 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608772&form=6&db=m Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111403&form=6&db=m Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinase, collagens, and Ki67 antigen in pleural malignant mesothelioma: an immunohistochemical and electron microscopic study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12612292&form=6&db=m Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15720796&form=6&db=m Inhibition of proliferation, migration, and matrix metalloprotease production in malignant mesothelioma cells by tyrosine kinase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608772&form=6&db=m Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16146743&form=6&db=m Transcriptional regulation of matrix metalloprotease gene expression in health and disease. causal interaction,unassigned 3,0 3.4.24.77 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20832124&form=6&db=m Serum haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complex as a biomarker of systemic inflammation in cattle. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18940384&form=6&db=m Increased plasma activity of metalloproteinase 2 in women with metabolic syndrome. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23010875&form=6&db=m ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26341859&form=6&db=m Metalloproteinases and leptin in vehicle drivers of public service with metabolic syndrome in Armenia, Quindío. causal interaction,unassigned 1,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28265178&form=6&db=m ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28430139&form=6&db=m The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29169989&form=6&db=m A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice. causal interaction,unassigned 3,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29912573&form=6&db=m Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33904577&form=6&db=m Implications of ADAM17 activation for hyperglycaemia, obesity and type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.24.77 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34003736&form=6&db=m ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Metrorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18812421&form=6&db=m Differential elevation of matrix metalloproteinase expression in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time. causal interaction,unassigned 3,0 3.4.24.77 Microphthalmos http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27748762&form=6&db=m Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells. causal interaction,unassigned 1,0 3.4.24.77 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10805337&form=6&db=m Serum elastase activity is elevated in migraine. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19627981&form=6&db=m Different circulating metalloproteinases profiles in women with migraine with and without aura. diagnostic usage,unassigned 1,0 3.4.24.77 Mixed Connective Tissue Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175110&form=6&db=m Serum levels of tissue inhibitor of metalloproteinases in patients with mixed connective tissue disease. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Monoclonal Gammopathy of Undetermined Significance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197802&form=6&db=m DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Mouth Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14660382&form=6&db=m In vitro and in vivo studies of the Yrp1 protease from Yersinia ruckeri and its role in protective immunity against enteric red mouth disease of salmonids. ongoing research,unassigned 2,0 3.4.24.77 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207110&form=6&db=m Acetylshikonin suppresses invasion of Porphyromonas gingivalis?infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis. causal interaction,unassigned 2,0 3.4.24.77 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30504396&form=6&db=m Contribution of MMP2 Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan. causal interaction,unassigned 3,0 3.4.24.77 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32453136&form=6&db=m A disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain. ongoing research,unassigned 3,0 3.4.24.77 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786875&form=6&db=m Involvement of the A disintegrin and metalloproteinase 9 in oral cancer cell invasion. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16723886&form=6&db=m Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya disease. therapeutic application,unassigned 1,0 3.4.24.77 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17327779&form=6&db=m Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya disease. unassigned - 3.4.24.77 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18824976&form=6&db=m Single nucleotide polymorphisms of tissue inhibitors of metalloproteinase genes in familial moyamoya disease. causal interaction,unassigned 3,0 3.4.24.77 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18824977&form=6&db=m Single nucleotide polymorphisms of tissue inhibitors of metalloproteinase genes in familial moyamoya disease. causal interaction,unassigned 3,0 3.4.24.77 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25280484&form=6&db=m The GC?+?CC genotype at position -418 in TIMP-2 promoter and the -1575GA/-1306CC genotype in MMP-2 is genetic predisposing factors for prevalence of moyamoya disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17643768&form=6&db=m Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.24.77 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19048177&form=6&db=m Promoter polymorphism (rs3755724, -55C/T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean population. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,2,0 3.4.24.77 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20682600&form=6&db=m Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat. ongoing research,unassigned 4,0 3.4.24.77 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10434353&form=6&db=m [Standard treatment of multiple myeloma] therapeutic application,unassigned 4,0 3.4.24.77 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12492574&form=6&db=m Size variants of beta-2-microglobulin-free human leucocyte antigen class I heavy chain make different contributions to its serum increase in multiple myeloma. ongoing research,unassigned 3,0 3.4.24.77 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197802&form=6&db=m DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25155463&form=6&db=m Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells. ongoing research,unassigned 2,0 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571216&form=6&db=m Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,3 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409549&form=6&db=m PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions. unassigned - 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16459731&form=6&db=m Misuse of serum matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 as a biomarker in multiple sclerosis. unassigned - 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097882&form=6&db=m Interferon beta treatment: bioavailability and antiviral activity in multiple sclerosis patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19267908&form=6&db=m Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19726693&form=6&db=m Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis. causal interaction,unassigned 1,0 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22367194&form=6&db=m Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophase phagocytic activities. unassigned - 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24283430&form=6&db=m Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24751386&form=6&db=m Relationship between metalloproteinase 2 and 9 concentrations and soluble CD154 expression in Iranian patients with multiple sclerosis. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Muscle Cramp http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22919691&form=6&db=m Cationic antimicrobial peptides serve as activation signals for the Salmonella Typhimurium PhoPQ and PmrAB regulons in vitro and in vivo. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16445880&form=6&db=m Animal models for muscular dystrophy; mechanism of disease and potential therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.24.77 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12915458&form=6&db=m Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins. ongoing research,unassigned 2,0 3.4.24.77 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21851816&form=6&db=m Fibroblasts from the muscles of Duchenne muscular dystrophy patients are resistant to cell detachment apoptosis. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26170062&form=6&db=m Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy. causal interaction,unassigned 3,0 3.4.24.77 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24895304&form=6&db=m Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. causal interaction,unassigned 1,0 3.4.24.77 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33965446&form=6&db=m RNAi-mediated suppression of insect metalloprotease inhibitor (IMPI) enhances Galleria mellonella susceptibility to fungal infection. therapeutic application,unassigned 1,0 3.4.24.77 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18081721&form=6&db=m Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukaemias and myelodysplastic syndromes. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1468146&form=6&db=m Activity of cathepsin H,B and metalloproteinase in the serum of patients with acute myocardial infarction. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12952845&form=6&db=m Early short-term treatment with doxycycline modulates postinfarction left ventricular remodeling. causal interaction,unassigned 4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309700&form=6&db=m Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15732032&form=6&db=m Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16960505&form=6&db=m Do metalloproteinases destabilize vulnerable atherosclerotic plaques? causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17383306&form=6&db=m A prospective evaluation of left ventricular remodeling after inaugural anterior myocardial infarction as a function of gene polymorphisms in the renin-angiotensin-aldosterone, adrenergic, and metalloproteinase systems. therapeutic application,unassigned 3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893005&form=6&db=m Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908467&form=6&db=m Effects of metoprolol treatment on a disintegrin metalloproteinase expression and extracellular matrix remodeling after myocardial infarction in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194418&form=6&db=m Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19099983&form=6&db=m [In vivo interleukin-10 gene transfer down-regulates myocardial matrix metalloproteinase and myocardial collagen expressions in rats with acute myocardial infarction] causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233617&form=6&db=m Metalloproteinase 2 cleaves in vitro recombinant TRAIL: Potential implications for the decreased serum levels of TRAIL after acute myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20516072&form=6&db=m Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload. therapeutic application,unassigned 3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625691&form=6&db=m Association of polymorphisms of zinc metalloproteinases with clinical response to stem cell therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20691304&form=6&db=m Usefulness of plasma tissue inhibitors of metalloproteinases as markers of prognosis after acute myocardial infarction. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21567088&form=6&db=m Dynamic expression of the main related indicators of thrombosis, inflammatory reaction and tissue damage in a rat model of myocardial infarction. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22163125&form=6&db=m The role of von Willebrand factor and ADAMTS13 in the no-reflow phenomenon: after primary percutaneous coronary intervention. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763262&form=6&db=m In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold? unassigned - 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098808&form=6&db=m Mechanisms Involved in the Beneficial Effects of Spironolactone after Myocardial Infarction. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24319718&form=6&db=m Effect of metalloproteinase inhibitor on early postinfarction remodeling in the most acute phase of myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25745981&form=6&db=m Cardiac tissue inhibitor of matrix metalloprotease 4 dictates cardiomyocyte contractility and differentiation of embryonic stem cells into cardiomyocytes: Road to therapy. therapeutic application,unassigned 2,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26132583&form=6&db=m Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease). causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969796&form=6&db=m Metalloproteinase production from macrophages - a perfect storm leading to atherosclerotic plaque rupture and myocardial infarction. therapeutic application,unassigned 1,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27135051&form=6&db=m Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis. causal interaction,unassigned 1,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27346868&form=6&db=m The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28550172&form=6&db=m Myocardial overexpression of TIMP3 after myocardial infarction exerts beneficial effects by promoting angiogenesis and suppressing early proteolysis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30571316&form=6&db=m Molecular Imaging of VWF (von Willebrand Factor) and Platelet Adhesion in Postischemic Impaired Microvascular Reflow. ongoing research,unassigned 4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32095288&form=6&db=m Effect of Acute Myocardial Infarction on a Disintegrin and Metalloprotease with Thrombospondin Motif 13 and Von Willebrand Factor and Their Relationship with Markers of Inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32246374&form=6&db=m Cardioprotective Effects of Metalloproteinase Inhibitor 1-({4-[(4-Chlorobenzoyl)amino]phenyl}sulfonyl-L-Proline in Modeled Acute Myocardial Infarction. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33064567&form=6&db=m MMP9 inhibition increases autophagic flux in chronic heart failure. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33093280&form=6&db=m Prognostic value of tissue inhibitor of metalloproteinase-matrix metalloproteinase biomarkers at 30 days in patients with acute myocardial infarction without reperfusion therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 3.4.24.77 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33882443&form=6&db=m Downregulation of microRNA-21-5p from macrophages-derived exosomes represses ventricular remodeling after myocardial infarction via inhibiting tissue inhibitors of metalloproteinase 3. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.4.24.77 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005216&form=6&db=m New aspects on angiotensin-converting enzyme: from gene to disease. diagnostic usage,unassigned 3,0 3.4.24.77 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34332258&form=6&db=m Dystrophin and metalloproteinase 9 in myocardial ischemia: A post-mortem immunohistochemical study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.4.24.77 Myopia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7601636&form=6&db=m Increased latent gelatinase activity in the sclera of visually deprived chicks. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Myopia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21421877&form=6&db=m Systematic investigation of the relationship between high myopia and polymorphisms of the MMP2, TIMP2 and TIMP3 genes by a DNA pooling approach. ongoing research,unassigned 3,0 3.4.24.77 Myopia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25112847&form=6&db=m Changes of TGF-?2, MMP-2, and TIMP-2 levels in the vitreous of patients with high myopia. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.24.77 Myotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26279213&form=6&db=m Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis. therapeutic application,unassigned 1,0 3.4.24.77 nadph dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25892053&form=6&db=m Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples. unassigned - 3.4.24.77 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19848251&form=6&db=m Double-stranded RNA poly(I:C) enhances matrix metalloproteinase mRNA expression in human nasal polyp epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20450704&form=6&db=m [Effects of double-stranded RNA poly(I:C) on matrix metalloproteinase mRNA expression in human nasal polyp epithelial cells] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562207&form=6&db=m Expression of a disintegrin and metalloproteinase 8 by inflammatory cells in nasal polyps. ongoing research,unassigned 2,0 3.4.24.77 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29484441&form=6&db=m A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability. unassigned - 3.4.24.77 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551050&form=6&db=m Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. causal interaction,unassigned 2,0 3.4.24.77 Nasopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093484&form=6&db=m ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Necrobiotic Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628797&form=6&db=m Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1292782&form=6&db=m Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1306136&form=6&db=m Evolutionary aspects of human cancer. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322396&form=6&db=m Domain structure of human 72-kDa gelatinase/type IV collagenase. Characterization of proteolytic activity and identification of the tissue inhibitor of metalloproteinase-2 (TIMP-2) binding regions. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322794&form=6&db=m Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1327511&form=6&db=m Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346086&form=6&db=m [New prognostic factors in human gastric carcinomas] causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1480077&form=6&db=m Association of high level of serum M(r) approximately 92,000 metalloproteinase activity with lung metastasis of rat 13,762 NF mammary adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1732058&form=6&db=m Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1773801&form=6&db=m Differential gene expression during multistage carcinogenesis. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2097083&form=6&db=m Stromelysin in tumor progression and metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2098274&form=6&db=m Growth factors in progression of human esophageal and gastric carcinomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541259&form=6&db=m Mechanisms of cellular invasiveness: a comparison of amnion invasion in vitro and metastatic behavior in vivo. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2689386&form=6&db=m Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830405&form=6&db=m High metalloproteinase inhibitor content of human cirrhosis and its possible conference of metastasis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2989606&form=6&db=m Expression of collagenase IV (basement membrane collagenase) activity in murine tumor cell hybrids that differ in metastatic potential. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3028610&form=6&db=m Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3044367&form=6&db=m Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7628877&form=6&db=m Cinnamic acid: a natural product with potential use in cancer intervention. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678936&form=6&db=m Immunohistochemical analysis of type IV collagenase expression in prostatic hyperplasia and adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7860222&form=6&db=m Stimulation of the 92-kD type IV collagenase promoter and enzyme expression in human melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8068180&form=6&db=m Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8206283&form=6&db=m Metalloproteinase domain structure, cellular invasion and metastasis. causal interaction,unassigned 2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8269280&form=6&db=m Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases and inhibitors involved in tumor matrix invasion. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380993&form=6&db=m Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631550&form=6&db=m The 72-kDa metalloproteinase immunostaining in cervical carcinoma: relationship with lymph nodal involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635390&form=6&db=m Cancer genetics and cell and molecular biology. Is this the way forward? causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8949652&form=6&db=m Matrix metalloproteinase-7 expression in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9023843&form=6&db=m New directions for radiation biology research in cancer of the uterine cervix. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049977&form=6&db=m Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells. ongoing research,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9075667&form=6&db=m In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9190892&form=6&db=m Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9263524&form=6&db=m [Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388364&form=6&db=m [Localization and expression of matrix metalloproteinase-7 in human prostate] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469303&form=6&db=m Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486578&form=6&db=m The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9550265&form=6&db=m Overview of matrix metalloproteinase expression in cultured human cells. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681807&form=6&db=m Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9699649&form=6&db=m Regulation of the Mr 72,000 type IV collagenase by the type I insulin-like growth factor receptor. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766654&form=6&db=m Neuropeptides induce Mr 92,000 type IV collagenase (matrix metalloprotease-9) activity in human prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816060&form=6&db=m Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188875&form=6&db=m Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10328230&form=6&db=m Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10352879&form=6&db=m Preclinical assessment of anti-cancer therapeutic strategies using in vivo videomicroscopy. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10359049&form=6&db=m Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409657&form=6&db=m Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485497&form=6&db=m Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10621835&form=6&db=m Proteolysis in colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10635313&form=6&db=m [Roles of matrix metalloproteinases and tissue inhibitor of metalloproteinase (TIMP) in cancer invasion and metastasis] ongoing research,unassigned 1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10853337&form=6&db=m [Study of matrix metalloproteinase-2 and -9 in thyroid papillary cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10963995&form=6&db=m Effects of thrombin/thrombosis in angiogenesis and tumour progression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11000516&form=6&db=m The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140879&form=6&db=m Antisense IL-10 abrogates the inhibitory effects of IL-10 production by transfected tumor cells. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11189300&form=6&db=m [Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11391619&form=6&db=m Granulocyte colony-stimulating factor (G-CSF)-mediated signaling regulates type IV collagenase activity in head and neck cancer cells. ongoing research,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11727959&form=6&db=m Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11792711&form=6&db=m ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. causal interaction,unassigned 1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819839&form=6&db=m Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11968018&form=6&db=m Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts. causal interaction,unassigned 2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12004062&form=6&db=m Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase. ongoing research,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169394&form=6&db=m Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma. ongoing research,unassigned 2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452001&form=6&db=m [Relationship of expression unbalance of matrix metalloproteinase and tissue inhibitor of metalloproteinase to invasiveness and metastasis in gastric carcinomas] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12487935&form=6&db=m [Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680160&form=6&db=m Randomised double blind placebo control study of adjuvant treatment with the metalloproteinase inhibitor, Marimastat in patients with inoperable colorectal hepatic metastases: significant survival advantage in patients with musculoskeletal side-effects. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706857&form=6&db=m Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB. ongoing research,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12724227&form=6&db=m Histone acetylation and gastrointestinal carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12765241&form=6&db=m Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12828172&form=6&db=m [Relationship between tissue inhibitors of metalloproteinase and metastasis and prognosis in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532978&form=6&db=m Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009718&form=6&db=m Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15050733&form=6&db=m Retroviral delivery of TIMP-2 inhibits H-ras-induced migration and invasion in MCF10A human breast epithelial cells. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15279895&form=6&db=m Inhibition of metalloproteinase activity by fruit extracts. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355971&form=6&db=m Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499569&form=6&db=m siRNA mediated inhibition of MMP-1 reduces invasive potential of a human chondrosarcoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15635158&form=6&db=m Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701845&form=6&db=m Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16088233&form=6&db=m Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16142392&form=6&db=m Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158215&form=6&db=m Possible pathophysiological role of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in metastatic brain tumor-associated intracerebral hemorrhage. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309203&form=6&db=m Prognostic value of matrix metalloproteinase-2 (MMP-2) expression in endometrial endometrioid adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474379&form=6&db=m Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912175&form=6&db=m Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17012225&form=6&db=m Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167337&form=6&db=m Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18196535&form=6&db=m Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202798&form=6&db=m Tissue inhibitor of metalloproteinase 2 (TIMP-2) expression in adenocarcinoma pleural effusions. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18265895&form=6&db=m MMP-2, TIMP-2 and CD44v6 Expression in Non-small-cell Lung Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413742&form=6&db=m Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18419677&form=6&db=m Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438343&form=6&db=m Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18612129&form=6&db=m Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18710625&form=6&db=m [Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18723480&form=6&db=m Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790756&form=6&db=m Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147814&form=6&db=m The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19207106&form=6&db=m Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19229865&form=6&db=m The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19296470&form=6&db=m MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19299146&form=6&db=m Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329328&form=6&db=m Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I). causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19343157&form=6&db=m Incorporation of biologic therapies in the management of gastroesophageal cancers. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19608765&form=6&db=m ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19617894&form=6&db=m Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19635101&form=6&db=m The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. causal interaction,therapeutic application,unassigned 2,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19826446&form=6&db=m Stromal collagenase in melanoma: a vascular connection. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996286&form=6&db=m ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103648&form=6&db=m Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103676&form=6&db=m Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20112342&form=6&db=m ADAM28 is a serological and histochemical marker for non-small-cell lung cancers. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236691&form=6&db=m Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20306451&form=6&db=m Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis. ongoing research,unassigned 2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20422344&form=6&db=m RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20482497&form=6&db=m Recent advances in the development of MMPIs and APNIs based on the pyrrolidine platforms. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599698&form=6&db=m YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20688878&form=6&db=m Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20739158&form=6&db=m Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells. causal interaction,unassigned 2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973496&form=6&db=m Dissociation Kinetics of an Enzyme-Inhibitor System Using Single-Molecule Force Measurements. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21064090&form=6&db=m Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21076843&form=6&db=m Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21171968&form=6&db=m Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21283680&form=6&db=m The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21494182&form=6&db=m ADAM-9 expression in intestinal-type adenocarcinoma of the sinonasal tract. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21612407&form=6&db=m Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21665938&form=6&db=m Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21670150&form=6&db=m Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701781&form=6&db=m Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21876729&form=6&db=m PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880579&form=6&db=m The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121096&form=6&db=m MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22215309&form=6&db=m Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349030&form=6&db=m Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22354764&form=6&db=m Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22636800&form=6&db=m Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22996753&form=6&db=m Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135915&form=6&db=m Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23157925&form=6&db=m Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23173124&form=6&db=m The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175213&form=6&db=m Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426077&form=6&db=m Cassia tora L. (Jue-ming-zi) has anticancer activity in TCA8113 cells in vitro and exerts anti-metastatic effects in vivo. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733191&form=6&db=m Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762791&form=6&db=m Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851508&form=6&db=m The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936642&form=6&db=m Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24465799&form=6&db=m ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24662834&form=6&db=m Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24667650&form=6&db=m ERR? signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells. causal interaction,unassigned 1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959222&form=6&db=m Chemokine (C-X-C motif) receptor 4 RNA interference inhibits bone metastasis in breast cancer. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25099234&form=6&db=m Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139103&form=6&db=m EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25151965&form=6&db=m Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213697&form=6&db=m miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25261583&form=6&db=m Biochemical and functional characterization of Bothropoidin: the first haemorrhagic metalloproteinase from Bothrops pauloensis snake venom. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320013&form=6&db=m EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25336660&form=6&db=m N-glycosylation regulates ADAM8 processing and activation. ongoing research,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25370353&form=6&db=m Thalidomide combined with irradiation alters the activity of two proteases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25435928&form=6&db=m Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25778452&form=6&db=m RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26278569&form=6&db=m MiR-761 Promotes Progression and Metastasis of Non-Small Cell Lung Cancer by Targeting ING4 and TIMP2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26425438&form=6&db=m A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26634009&form=6&db=m Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26711609&form=6&db=m [Expression and pathological mechanism of MMP-9 and HIF-2? in CD133(+) lung cancer stem cells]. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058897&form=6&db=m KDM1A promotes tumor cell invasion by silencing TIMP3 in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27060463&form=6&db=m EMMPRIN/CD147 is an independent prognostic biomarker in cutaneous melanoma. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277077&form=6&db=m Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27407033&form=6&db=m Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27486337&form=6&db=m Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622031&form=6&db=m TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123746&form=6&db=m High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28362704&form=6&db=m Downregulation of ADAMTS18 May Serve as a Poor Prognostic Biomarker for Cervical Cancer Patients. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28537886&form=6&db=m ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672103&form=6&db=m Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765266&form=6&db=m ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943961&form=6&db=m The roles of ARHGAP10 in the proliferation, migration and invasion of lung cancer cells. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29118335&form=6&db=m ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29137479&form=6&db=m The role of the carbohydrates in plasmatic membrane. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29138461&form=6&db=m Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29162512&form=6&db=m MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29620263&form=6&db=m TPX2 silencing mediated by joint action of microvesicles and ultrasonic radiation inhibits the migration and invasion of SKOV3 cells. diagnostic usage,ongoing research,unassigned 4,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29636998&form=6&db=m EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872742&form=6&db=m Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29882245&form=6&db=m SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30024495&form=6&db=m Clinical significance of matrix metalloproteinase-2 in endometrial cancer: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30080411&form=6&db=m Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor ?B-Matrix Metalloproteinase Signaling. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30190423&form=6&db=m Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis. ongoing research,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401693&form=6&db=m Necuparanib, A Multitargeting Heparan Sulfate Mimetic, Targets Tumor and Stromal Compartments in Pancreatic Cancer. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30431071&form=6&db=m Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review). causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30504396&form=6&db=m Contribution of MMP2 Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30654764&form=6&db=m Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842824&form=6&db=m In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30925457&form=6&db=m Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30940630&form=6&db=m Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31463899&form=6&db=m Inhibition of ADAMTS1 Expression by Lentiviral CRISPR/Cas9 Gene Editing Technology. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31499120&form=6&db=m Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-?/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31499542&form=6&db=m Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31588243&form=6&db=m TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31654063&form=6&db=m SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31970775&form=6&db=m Microenvironment-induced TIMP2 loss by cancer-secreted exosomal miR-4443 promotes liver metastasis of breast cancer. ongoing research,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32291412&form=6&db=m The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis. causal interaction,unassigned 4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32522006&form=6&db=m ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32565938&form=6&db=m Metastasis-associated gene MAPK15 promotes the migration and invasion of osteosarcoma cells via the c-Jun/MMPs pathway. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32575507&form=6&db=m Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32669083&form=6&db=m Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32875951&form=6&db=m Structure, regulatory factors and cancer-related physiological effects of ADAM9. causal interaction,unassigned 3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33219891&form=6&db=m Squalene deters drivers of RCC disease progression beyond VHL status. unassigned - 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33294270&form=6&db=m Resveratrol-mediated ADAM9 degradation decreases cancer progression and provides synergistic effects in combination with chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33864820&form=6&db=m Melatonin indirectly decreases gastric cancer cell proliferation and invasion via effects on cancer-associated fibroblasts. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33987357&form=6&db=m Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089582&form=6&db=m Dual inhibition of cMET and EGFR by microRNA-338-5p suppresses metastasis of esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34110633&form=6&db=m Hypoxia-Inducible Exosomes Facilitate Liver-Tropic Premetastatic Niche in Colorectal Cancer. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249415&form=6&db=m Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1284126&form=6&db=m Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322938&form=6&db=m Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323219&form=6&db=m Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1325287&form=6&db=m Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1342967&form=6&db=m Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346086&form=6&db=m [New prognostic factors in human gastric carcinomas] causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645757&form=6&db=m Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646178&form=6&db=m Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647974&form=6&db=m Natural human monocyte gelatinase and its inhibitor. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662201&form=6&db=m Efficient purification of TIMP-2 from culture medium conditioned by human hepatoma cell line, and its inhibitory effects on metalloproteinases and in vitro tumor invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1773801&form=6&db=m Differential gene expression during multistage carcinogenesis. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901643&form=6&db=m Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1932376&form=6&db=m Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1946041&form=6&db=m Characterization of gelatin-degrading metalloproteinase activities of the Dunning rat prostate tumor grown in nude mice. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2009533&form=6&db=m Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2045200&form=6&db=m Constitutive expression and secretion of proteases in non-metastatic SP1 mammary carcinoma cells and its metastatic sublines. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2097083&form=6&db=m Stromelysin in tumor progression and metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2098274&form=6&db=m Growth factors in progression of human esophageal and gastric carcinomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168825&form=6&db=m The effect of recombinant tumor necrosis factor-alpha on superoxide and metalloproteinase production by synovial cells and chondrocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169765&form=6&db=m Protective role of transforming growth factor beta (TGF beta) in tumor-induced degradation of basement membranes. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2280991&form=6&db=m Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2374521&form=6&db=m Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535940&form=6&db=m Identification of a metalloproteinase co-purifying with rat tumour collagenase and the characteristics of fragments of both enzymes. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539808&form=6&db=m Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase. ongoing research,therapeutic application,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541259&form=6&db=m Mechanisms of cellular invasiveness: a comparison of amnion invasion in vitro and metastatic behavior in vivo. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2542176&form=6&db=m Gelatin-degrading type IV collagenase isolated from human small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2810294&form=6&db=m The role of cytokines in chondrocyte mediated cartilage degradation. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824039&form=6&db=m Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830405&form=6&db=m High metalloproteinase inhibitor content of human cirrhosis and its possible conference of metastasis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837354&form=6&db=m Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838321&form=6&db=m Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040318&form=6&db=m Biochemical mechanisms of tumor invasion and metastases. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3044367&form=6&db=m Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3098847&form=6&db=m Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3151258&form=6&db=m Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3416307&form=6&db=m Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3542141&form=6&db=m Analysis of the cell membrane proteolytic enzymes of the B16, F1, F10, and BL6 melanoma and their role in target cell destruction. therapeutic application,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3779529&form=6&db=m The K.G. McKenzie award lecture--1986. Effects of extracellular matrix proteins on the growth and differentiation of an anaplastic glioma cell line. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6329972&form=6&db=m A fibrosarcoma model derived from mouse embryo cells: growth properties and secretion of collagenase and metalloproteinase inhibitor (TIMP) by tumour cell lines. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489254&form=6&db=m Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7532319&form=6&db=m Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7558459&form=6&db=m Differences in expression of metalloproteinases and plasminogen activators in murine melanocytes and B16 melanoma variants: lack of association with in vitro invasion. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7589259&form=6&db=m Degradation of fibronectin fibrils by matrilysin and characterization of the degradation products. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7591296&form=6&db=m A zinc metalloproteinase is responsible for the release of CD30 on human tumor cell lines. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7606886&form=6&db=m Degradation of endothelial cell matrix collagen is correlated with induction of stromelysin by an activated ras oncogene. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7619826&form=6&db=m Neutrophil elastase processing of gelatinase A is mediated by extracellular matrix. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7628877&form=6&db=m Cinnamic acid: a natural product with potential use in cancer intervention. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7629728&form=6&db=m An in vivo model for screening peptidomimetic inhibitors of gelatinase A. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7641422&form=6&db=m Localization of messenger RNA for tissue inhibitor of metalloproteinases-1 and type IV collagenases/gelatinases in monkey hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7657517&form=6&db=m Metalloproteinases in tumor progression: the contribution of MMP-9. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678936&form=6&db=m Immunohistochemical analysis of type IV collagenase expression in prostatic hyperplasia and adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7682768&form=6&db=m 92-kd gelatinase is actively expressed by eosinophils and stored by neutrophils in squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7764458&form=6&db=m Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7860222&form=6&db=m Stimulation of the 92-kD type IV collagenase promoter and enzyme expression in human melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7872603&form=6&db=m Cytokine regulation of gelatinase production by head and neck squamous cell carcinoma: the role of tumor necrosis factor-alpha. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876229&form=6&db=m An extracellular proteasome-like structure from C6 astrocytoma cells with serine collagenase IV activity and metallo-dependent activity on alpha-casein and beta-insulin. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7882342&form=6&db=m Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7951414&form=6&db=m Plasminogen activator and metalloprotease activities of Du-145, PC-3, and 1-LN-PC-3-1A human prostate tumors grown in nude mice: correlation with tumor invasive behavior. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7951846&form=6&db=m Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7966813&form=6&db=m Interleukin-1 beta induces differential gene expression in aortic smooth muscle cells. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7978821&form=6&db=m Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8006458&form=6&db=m Cyclosporin A enhances cytokine and phorbol ester-induced fibroblast collagenase expression. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012988&form=6&db=m Autocrine factor enhancing the secretion of M(r) 95,000 gelatinase (matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8015608&form=6&db=m A matrix metalloproteinase expressed on the surface of invasive tumour cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020584&form=6&db=m Paracrine factor and cell-cell contact-mediated induction of protease and c-ets gene expression in malignant keratinocyte/dermal fibroblast cocultures. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8052311&form=6&db=m Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor. therapeutic application,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8062280&form=6&db=m Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8064484&form=6&db=m Comparison of the inflammatory response to particulate polymethylmethacrylate debris with and without barium sulfate. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8068180&form=6&db=m Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8068181&form=6&db=m A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8077060&form=6&db=m Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8113946&form=6&db=m In vivo inflammatory response to polymethylmethacrylate particulate debris: effect of size, morphology, and surface area. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144503&form=6&db=m Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8180955&form=6&db=m Stimulation of TIMP-1 and metalloproteinase production in co-cultures of human tumor cells and human fibroblasts. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8187840&form=6&db=m Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207074&form=6&db=m Induction of fibroblast 92 kDa gelatinase/type IV collagenase expression by direct contact with metastatic tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253535&form=6&db=m TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8262328&form=6&db=m Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8269280&form=6&db=m Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases and inhibitors involved in tumor matrix invasion. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8275936&form=6&db=m Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8313385&form=6&db=m Transforming growth factor beta 1 regulation of metalloproteinase production in cultured human cervical epithelial cells. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8507225&form=6&db=m Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8556714&form=6&db=m Tumor necrosis factor alpha and lymphotoxin stimulate human myeloblastic leukemia cell (ML-1) invasion through a reconstituted basement membrane (Matrigel) with concomitant induction of 92 kDa gelatinase secretion. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8563023&form=6&db=m Developmental expression of MMP-9 (gelatinase B) mRNA in mouse embryos. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8599579&form=6&db=m Protein kinase C isotypes required for phorbol-ester induction of stromelysin-1 in rat fibroblasts. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8610113&form=6&db=m Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8611434&form=6&db=m Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8625169&form=6&db=m Plasma assay of gelatinase B: tissue inhibitor of metalloproteinase complexes in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626123&form=6&db=m Recurrence patterns in locally advanced cervical carcinoma: role of nodal status and 72-kDa metalloproteinase index. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626132&form=6&db=m Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631550&form=6&db=m The 72-kDa metalloproteinase immunostaining in cervical carcinoma: relationship with lymph nodal involvement. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8674273&form=6&db=m Induction of matrix metalloproteinase 9 expression in breast carcinoma cells by a soluble factor from fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712742&form=6&db=m Immunohistochemical evaluation of type IV collagenase (72-kd metalloproteinase) in prostatic intraepithelial neoplasia. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712754&form=6&db=m Increased serum 72 KDa metalloproteinase in serous ovarian tumors: comparison with CA 125. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8731393&form=6&db=m Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752667&form=6&db=m Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8753775&form=6&db=m Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8758934&form=6&db=m Correspondence re: N-B. Liabakk et al., matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res., 56: 190-196, 1966. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8772198&form=6&db=m Tumor necrosis factor alpha (TNFalpha) induces pro-matrix metalloproteinase 9 production in human uterine cervical fibroblasts but interleukin 1alpha antagonizes the inductive effect of TNFalpha. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8773300&form=6&db=m Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8814990&form=6&db=m Membrane type-matrix metalloproteinase and tumor invasion. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8841807&form=6&db=m Local activity of matrix metalloproteinases in a case of botryoid sarcoma. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8888065&form=6&db=m Metalloproteinase inhibitors and the prevention of connective tissue breakdown. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8938794&form=6&db=m Cytokine regulation of the matrix metalloproteinases and their inhibitors in human papillomavirus-18 transformed human prostatic tumor cell lines. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8946145&form=6&db=m Flow cytometric analysis of gelatinase B (MMP-9) activity using immobilized fluorescent substrate on microspheres. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8949652&form=6&db=m Matrix metalloproteinase-7 expression in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8951600&form=6&db=m Detection of viral infections by in situ PCR: theoretical considerations and possible value in diagnostic pathology. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8989924&form=6&db=m Effects of in vivo culture of murine mammary adenocarcinoma cells on tumor and metastatic growth. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9029292&form=6&db=m A comparison of the inflammatory potential of particulates derived from two composite materials. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030563&form=6&db=m Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9040946&form=6&db=m Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9042307&form=6&db=m Antiinvasive effects of Tiazofurin on liver-metastatic human colon carcinoma xenografts. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049977&form=6&db=m Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9057654&form=6&db=m Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in reactive and neoplastic lymphoid cells. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9075667&form=6&db=m In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9096668&form=6&db=m Gelatinase B (MMP-9) production and expression by stromal cells in the normal and adult thymus and experimental thymic lymphoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9162049&form=6&db=m Interleukin-1beta secreted from monocytic cells induces the expression of matrilysin in the prostatic cell line LNCaP. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9190892&form=6&db=m Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9195133&form=6&db=m A metalloproteinase inhibitor blocks the shedding of soluble cytokine receptors and processing of transmembrane cytokine precursors in human monocytic cells. therapeutic application,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9197532&form=6&db=m Two transcription factors, E1AF and N-myc, correlate with the invasiveness of neuroblastoma cell lines. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9199213&form=6&db=m Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9213309&form=6&db=m Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9243304&form=6&db=m Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNF alpha processing. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9254899&form=6&db=m Plasminogen activator and matrix metalloproteinase production and extracellular matrix degradation by rat prostate cancer cells in vitro: correlation with metastatic behavior in vivo. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9263524&form=6&db=m [Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9275032&form=6&db=m Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9290703&form=6&db=m Fibroblast-directed expression and localization of 92-kDa type IV collagenase along the tumor-stroma interface in an in vitro three-dimensional model of human squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9294650&form=6&db=m Human prostate tumor angiogenesis in nude mice: metalloprotease and plasminogen activator activities during tumor growth and neovascularization of subcutaneously injected matrigel impregnated with human prostate tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9350241&form=6&db=m [Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388364&form=6&db=m [Localization and expression of matrix metalloproteinase-7 in human prostate] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393739&form=6&db=m Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486578&form=6&db=m The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9499190&form=6&db=m Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9508784&form=6&db=m In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514098&form=6&db=m Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9550265&form=6&db=m Overview of matrix metalloproteinase expression in cultured human cells. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9570387&form=6&db=m Effects of vitamin D3 on proliferation of cancer cells in vitro. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9579573&form=6&db=m Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine kinase pathway in mammary tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9609547&form=6&db=m Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9610608&form=6&db=m Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9619102&form=6&db=m Placental endogenous retrovirus (ERV): structural, functional, and evolutionary significance. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626453&form=6&db=m Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9656237&form=6&db=m [Therapy for non-small cell lung cancer: new concepts based on molecular biology] causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731514&form=6&db=m Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9733803&form=6&db=m Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9735398&form=6&db=m Active-MMP2 in cancer cell nests of oral cancer patients: correlation with lymph node metastasis. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9748307&form=6&db=m Intracellular maturation of the mouse metalloprotease disintegrin MDC15. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766654&form=6&db=m Neuropeptides induce Mr 92,000 type IV collagenase (matrix metalloprotease-9) activity in human prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9768911&form=6&db=m Effects of particulate debris on macrophage-dependent fibroblast stimulation in coculture. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9772531&form=6&db=m [Effects of TIMP-2 gene transfection on biological behaviors of a metastatic human lung carcinoma cell line] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9808534&form=6&db=m Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816060&form=6&db=m Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816309&form=6&db=m TIMP1 and adverse prognosis in non-small cell lung cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9818177&form=6&db=m ADAMs: focus on the protease domain. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9818827&form=6&db=m An orthotopic floor-of-mouth cancer model allows quantification of tumor invasion. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846984&form=6&db=m Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9890556&form=6&db=m Enhancement of the surface expression of tumor necrosis factor alpha (TNFalpha) but not the p55 TNFalpha receptor in the THP-1 monocytic cell line by matrix metalloprotease inhibitors. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918213&form=6&db=m Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920899&form=6&db=m Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022821&form=6&db=m Comparative molecular genetic profiles of anaplastic astrocytomas/glioblastomas multiforme and their subsequent recurrences. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10050107&form=6&db=m The matrix metalloprotease pump-1 (MMP-7, Matrilysin): A candidate marker/target for ovarian cancer detection and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10050880&form=6&db=m CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188770&form=6&db=m Escherichia coli lipopolysaccharide potentiation and inhibition of rat neonatal microglia superoxide anion generation: correlation with prior lactic dehydrogenase, nitric oxide, tumor necrosis factor-alpha, thromboxane B2, and metalloprotease release. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188875&form=6&db=m Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10325514&form=6&db=m PIN I-III: when should we interfere? causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10326701&form=6&db=m Expression of vascular endothelial growth factor related to 72-kilodalton metalloproteinase immunostaining in patients with serous ovarian tumors. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10328230&form=6&db=m Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10362259&form=6&db=m The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10362800&form=6&db=m Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10366463&form=6&db=m MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376979&form=6&db=m Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408859&form=6&db=m Quantitation of TIMP-1 in plasma of healthy blood donors and patients with advanced cancer. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409657&form=6&db=m Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10415735&form=6&db=m Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417774&form=6&db=m Gelatinase B (MMP-9), but not its inhibitor (TIMP-1), dictates the growth rate of experimental thymic lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10426662&form=6&db=m Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10430098&form=6&db=m Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10434353&form=6&db=m [Standard treatment of multiple myeloma] therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10435007&form=6&db=m Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473866&form=6&db=m Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485497&form=6&db=m Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10491398&form=6&db=m Function of alpha3beta1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2). therapeutic application,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10498596&form=6&db=m The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10521439&form=6&db=m Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE). causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10537320&form=6&db=m Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579851&form=6&db=m New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597309&form=6&db=m Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10621835&form=6&db=m Proteolysis in colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10635313&form=6&db=m [Roles of matrix metalloproteinases and tissue inhibitor of metalloproteinase (TIMP) in cancer invasion and metastasis] ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10652425&form=6&db=m Expression of emmprin by oral squamous cell carcinoma. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10681423&form=6&db=m Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10685633&form=6&db=m Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10713661&form=6&db=m Induction of matrix metalloprotease-7 is common in mucinous ovarian tumors including early stage disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10743803&form=6&db=m Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10744726&form=6&db=m Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753951&form=6&db=m Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10754522&form=6&db=m Synthetic inhibitor of matrix metalloproteinases (batimastat) reduces prostate cancer growth in an orthotopic rat model. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799547&form=6&db=m Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10810650&form=6&db=m Potential applications of tissue inhibitor of metalloproteinase (TIMP) overexpression for cancer gene therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10822133&form=6&db=m Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10849774&form=6&db=m Matrix metalloproteinases and TACE play a role in the pathogenesis of endometriosis. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10852638&form=6&db=m Clinical potential of matrix metalloprotease inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10853337&form=6&db=m [Study of matrix metalloproteinase-2 and -9 in thyroid papillary cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861487&form=6&db=m Synthetic inhibitor of matrix metalloproteases decreases tumor growth and metastases in a syngeneic model of rat prostate cancer in vivo. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10938388&form=6&db=m Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10961936&form=6&db=m Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10963995&form=6&db=m Effects of thrombin/thrombosis in angiogenesis and tumour progression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10971741&form=6&db=m Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards type-2 in experimental pulmonary tuberculosis in Balb/c mice. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11000516&form=6&db=m The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028485&form=6&db=m Expression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059766&form=6&db=m Treatment of colorectal liver metastases by adenoviral transfer of tissue inhibitor of metalloproteinases-2 into the liver tissue. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062605&form=6&db=m Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11076665&form=6&db=m Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093042&form=6&db=m The role of angiogenesis in the accumulation of peritoneal fluid in benign conditions and the development of malignant ascites in the female. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11102971&form=6&db=m Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108241&form=6&db=m Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140879&form=6&db=m Antisense IL-10 abrogates the inhibitory effects of IL-10 production by transfected tumor cells. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156425&form=6&db=m Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11244951&form=6&db=m [The suppressing effect of TIMP-3 gene transfection on the invasion and metastasis of human lung carcinoma cells line] diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278623&form=6&db=m Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11299727&form=6&db=m Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301286&form=6&db=m TACE and other ADAM proteases as targets for drug discovery. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11308991&form=6&db=m Usefulness of VEGF, MMP-2, MMP-3 and TIMP-2 serum level evaluation in patients with adrenal tumours. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11334139&form=6&db=m ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342973&form=6&db=m Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11351259&form=6&db=m Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375402&form=6&db=m Regulation of membrane metalloproteolytic cleavage of L-selectin (CD62l) by the epidermal growth factor domain. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389678&form=6&db=m Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11399950&form=6&db=m Retinoic acids reduce matrilysin (matrix metalloproteinase 7) and inhibit tumor cell invasion in human colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11406201&form=6&db=m Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429784&form=6&db=m Role of matrix metalloproteinase-9 in progression of mouse skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11433430&form=6&db=m Interferon-beta treatment of experimental autoimmune encephalomyelitis leads to rapid nonapoptotic termination of T cell infiltration. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477554&form=6&db=m Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532975&form=6&db=m Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576338&form=6&db=m A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592092&form=6&db=m MMP-19: cellular localization of a novel metalloproteinase within normal breast tissue and mammary gland tumours. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11640888&form=6&db=m Retinoic acid and vitamin E modulate expression and release of CD178 in carcinoma cells: consequences for induction of apoptosis in CD95-sensitive cells. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11640889&form=6&db=m Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714086&form=6&db=m New and emerging pharmacological strategies in the management of chronic heart failure. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11727959&form=6&db=m Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782944&form=6&db=m Shedding light on sheddases: role in growth and development. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11792711&form=6&db=m ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11817044&form=6&db=m Separation and identification methods for metalloproteinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830478&form=6&db=m Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia. ongoing research,therapeutic application,unassigned 2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11844598&form=6&db=m Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857311&form=6&db=m Stromelysin-3 is expressed by aggressive meningiomas. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857380&form=6&db=m Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857410&form=6&db=m Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. therapeutic application,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11862249&form=6&db=m Nonsteroidal Anti-Inflammatory Drugs and Prostaglandins: Their Interactions and Effects on the Particulate-Induced Inflammatory Process Implicated in Joint Implant-Loosening and on Monosodium Urate Crystal-Induced Inflammation. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867212&form=6&db=m Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11884025&form=6&db=m Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11923519&form=6&db=m Matrix metalloproteinase inhibitors and cancer: trials and tribulations. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11948139&form=6&db=m The antiangiogenic agent neovastat (AE-941) inhibits vascular endothelial growth factor-mediated biological effects. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966774&form=6&db=m Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11968018&form=6&db=m Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11988096&form=6&db=m Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12004062&form=6&db=m Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12015741&form=6&db=m Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12112311&form=6&db=m Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130577&form=6&db=m Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12135369&form=6&db=m The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12163483&form=6&db=m Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208655&form=6&db=m Metalloproteinases and the modulation of GH signaling. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12403792&form=6&db=m Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12404291&form=6&db=m Immunohistochemical expression of vascular endothelial growth factor, matrix metalloproteinase 2, and matrix metalloproteinase 9 in cutaneous melanocytic lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414665&form=6&db=m Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12441351&form=6&db=m Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. ongoing research,therapeutic application,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12444039&form=6&db=m Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12456779&form=6&db=m The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472889&form=6&db=m Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472997&form=6&db=m Tissue structure, and IL-1beta, IL-8, and TNF-alpha secretions after contact by engineered human oral mucosa with dentifrices. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12538453&form=6&db=m Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12549623&form=6&db=m Constitutive production of parathyroid hormone-related protein (PTHrP) by fibroblasts derived from normal and pathological human breast tissue. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12554354&form=6&db=m Differential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophils. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12556225&form=6&db=m Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576417&form=6&db=m Matrix metalloproteinases, angiogenesis, and cancer: commentary re: A. C. Lockhart et al., Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin. Cancer Res., 9: 00-00, 2003. causal interaction,therapeutic application,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622136&form=6&db=m Tracking cell invasion of human glioma cells and suppression by anti-matrix metalloproteinase agent in rodent brain-slice model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631221&form=6&db=m Effects of hepatocyte growth factor on the expression of matrix metalloproteinases and their tissue inhibitors during the endometrial cancer invasion in a three-dimensional coculture. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12673944&form=6&db=m [Immunohistochemical findings in prolonged cerebral hypoxia] causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12704680&form=6&db=m Efficacy of dendrimer-mediated angiostatin and TIMP-2 gene delivery on inhibition of tumor growth and angiogenesis: in vitro and in vivo studies. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706857&form=6&db=m Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711607&form=6&db=m Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12714588&form=6&db=m Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12721755&form=6&db=m Tamoxifen induces apoptosis in Fas+ tumor cells by upregulating the expression of Fas ligand. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727852&form=6&db=m Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730960&form=6&db=m ADAM-10 and ADAM-17 in the inflamed human CNS. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12736275&form=6&db=m BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12749850&form=6&db=m Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site. therapeutic application,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12765241&form=6&db=m Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12814950&form=6&db=m ADAMTS1: a matrix metalloprotease with angioinhibitory properties. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12814963&form=6&db=m CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans. therapeutic application,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12844362&form=6&db=m Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866026&form=6&db=m Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866146&form=6&db=m [Giant-cell tumor of the bone] causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882097&form=6&db=m Surgical treatment and prognostic factors in giant-cell tumor of bone. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12897567&form=6&db=m Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901873&form=6&db=m TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954328&form=6&db=m Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958188&form=6&db=m Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12972643&form=6&db=m Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499647&form=6&db=m TACE is required for fetal murine cardiac development and modeling. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500390&form=6&db=m CD10 is a key enzyme involved in the activation of tumor-activated peptide prodrug CPI-0004Na and novel analogues: implications for the design of novel peptide prodrugs for the therapy of CD10+ tumors. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14522908&form=6&db=m Dual stromelysin-3 function during natural mouse mammary tumor virus-ras tumor progression. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532978&form=6&db=m Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14572651&form=6&db=m Evidence that elastase is the TNF-R75 shedding enzyme in resting human polymorphonuclear leukocytes. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14579524&form=6&db=m Design strategies for the identification of MMP-13 and Tace inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14598310&form=6&db=m ADAMs family members as amyloid precursor protein alpha-secretases. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623895&form=6&db=m Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14629269&form=6&db=m The favorable prognostic impact of tissue inhibitor of matrix metalloproteinases-1 protein overexpression in breast cancer cells. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654782&form=6&db=m Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654977&form=6&db=m Promoter methylation status of multiple genes in brain metastases of solid tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713188&form=6&db=m Modeling of enzyme-substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718605&form=6&db=m Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734484&form=6&db=m Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14735194&form=6&db=m Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14961226&form=6&db=m Sharks: a potential source of antiangiogenic factors and tumor treatments. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962105&form=6&db=m Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996435&form=6&db=m High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044327&form=6&db=m Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15053235&form=6&db=m Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075244&form=6&db=m Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075334&form=6&db=m Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE). unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094768&form=6&db=m eIF-4E expression and its role in malignancies and metastases. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15100227&form=6&db=m Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102849&form=6&db=m Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15111578&form=6&db=m Modulation of Sub-RPE deposits in vitro: a potential model for age-related macular degeneration. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167830&form=6&db=m Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15206946&form=6&db=m Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231657&form=6&db=m Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanism. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239135&form=6&db=m Metalloproteinase inhibition augments antitumor efficacy of the anti-CD30 immunotoxin Ki-3(scFv)-ETA' against human lymphomas in vivo. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15270589&form=6&db=m Magnetic resonance imaging detects early changes in microvascular permeability in xenograft tumors after treatment with the matrix metalloprotease inhibitor Prinomastat. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15279895&form=6&db=m Inhibition of metalloproteinase activity by fruit extracts. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15280448&form=6&db=m Interleukin-10 induced activating transcription factor 3 transcriptional suppression of matrix metalloproteinase-2 gene expression in human prostate CPTX-1532 Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297395&form=6&db=m Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15307194&form=6&db=m Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15308656&form=6&db=m Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme. therapeutic application,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319441&form=6&db=m Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15320727&form=6&db=m The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15356104&form=6&db=m Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374996&form=6&db=m Autocrine secretion of Fas ligand shields tumor cells from Fas-mediated killing by cytotoxic lymphocytes. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520187&form=6&db=m Profiling the evolution of human metastatic bladder cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592032&form=6&db=m Analysis of prostate cancer by proteomics using tissue specimens. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625312&form=6&db=m Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15633397&form=6&db=m [Diagnosis and treatment of tumor metastases] causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15635158&form=6&db=m Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15671071&form=6&db=m Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with minimal-change nephrotic syndrome. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15699789&form=6&db=m Proteases and emphysema. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701845&form=6&db=m Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15713681&form=6&db=m Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme. therapeutic application,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15729716&form=6&db=m Metalloproteinases and their inhibitors in tumor angiogenesis. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736455&form=6&db=m Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15774823&form=6&db=m Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781324&form=6&db=m Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend". causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15785755&form=6&db=m Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15832061&form=6&db=m Cerebral ischemic events in patients with advanced lung or prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868625&form=6&db=m Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868959&form=6&db=m Proenzyme therapy of cancer. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878795&form=6&db=m Combination cancer chemotherapy with one compound: pluripotent bradykinin antagonists. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15906368&form=6&db=m Predictive value of lymph node and tumor matrix metalloproteinase expression in the analysis of metastatic periampullary tumors. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15925282&form=6&db=m Oxidative stress and 8-iso-prostaglandin F(2alpha) induce ectodomain shedding of CD163 and release of tumor necrosis factor-alpha from human monocytes. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15928670&form=6&db=m Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930294&form=6&db=m A role for ADAM12 in breast tumor progression and stromal cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15972109&form=6&db=m U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002723&form=6&db=m Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16020548&form=6&db=m Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16088233&form=6&db=m Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103944&form=6&db=m AG-3340 (Agouron Pharmaceuticals Inc). causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115946&form=6&db=m Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16126171&form=6&db=m Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158215&form=6&db=m Possible pathophysiological role of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in metastatic brain tumor-associated intracerebral hemorrhage. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16173790&form=6&db=m Matrix metalloprotease triggered delivery of cancer chemotherapeutics from hydrogel matrixes. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213489&form=6&db=m ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251041&form=6&db=m [Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone] diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16261825&form=6&db=m Isolation, characterization, and expression of stromelysin-1 in primary tumors of dogs. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16298911&form=6&db=m Biomarkers for diagnosing and monitoring autoimmune diseases. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309203&form=6&db=m Prognostic value of matrix metalloproteinase-2 (MMP-2) expression in endometrial endometrioid adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322233&form=6&db=m Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16332693&form=6&db=m Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16333657&form=6&db=m Changes in biochemical parameters after anterior cruciate ligament injury. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357344&form=6&db=m Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16368650&form=6&db=m Immunohistochemical study of tumor necrosis factor-alpha, matrix metalloproteinase-12, and tissue inhibitor of metalloproteinase-2 on alveolar macrophages of BALB/c mice exposed to short-term cigarette smoke. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16378499&form=6&db=m Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16399672&form=6&db=m Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16478662&form=6&db=m EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502411&form=6&db=m Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16503735&form=6&db=m Antiprotease therapy in cancer: hot or not? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525716&form=6&db=m Interferon-gamma down-regulates expression of tumor necrosis factor-alpha converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585599&form=6&db=m Ovarian Cancer Cells Polarize Macrophages Toward A Tumor-Associated Phenotype. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16600387&form=6&db=m TACE-dependent EGF receptor activation in angiotensin-II-induced kidney disease. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16607276&form=6&db=m ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627261&form=6&db=m Vascular endothelial growth factor expression in the basal subtype of breast carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16630504&form=6&db=m [Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16633062&form=6&db=m Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636812&form=6&db=m Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface. causal interaction,therapeutic application,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16641452&form=6&db=m Minocycline impedes African trypanosome invasion of the brain in a murine model. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16701099&form=6&db=m Hepatic ischemia/reperfusion injury is prevented by a novel matrix metalloproteinase inhibitor, ONO-4817. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709900&form=6&db=m An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16771728&form=6&db=m Increasing expression of extracellular matrix metalloprotease inducer in renal cell carcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16784978&form=6&db=m CD10 expression in pancreatic endocrine tumors: correlation with prognostic factors and survival. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806998&form=6&db=m High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16826041&form=6&db=m Extracellular matrix metalloprotease inducer stimulates fibroblast-mediated tumor growth in vivo. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16827870&form=6&db=m Upregulation of ADAM19 in chronic allograft nephropathy. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835704&form=6&db=m Correlation between genetic and biological aspects in primary non-metastatic breast cancers and corresponding synchronous axillary lymph node metastasis. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16877361&form=6&db=m Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16891410&form=6&db=m Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892341&form=6&db=m Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900751&form=6&db=m Upregulation of ADAM-17 expression in active lesions in multiple sclerosis. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912175&form=6&db=m Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912185&form=6&db=m Multiple Acquired Renal Carcinoma Tumor Capabilities Abolished upon Silencing of ADAM17. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949904&form=6&db=m ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16952909&form=6&db=m The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16978202&form=6&db=m Increasing EMMPRIN and matriptase expression in hepatocellular carcinoma: tissue microarray analysis of immunohistochemical scores with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980310&form=6&db=m Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980949&form=6&db=m Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16983145&form=6&db=m A cancer cell metalloprotease triad regulates the basement membrane transmigration program. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17009991&form=6&db=m Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17012225&form=6&db=m Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047157&form=6&db=m A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17076530&form=6&db=m Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17082335&form=6&db=m Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17099142&form=6&db=m Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17106710&form=6&db=m ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17115023&form=6&db=m Expression profiles associated with aggressive behavior in Merkel cell carcinoma. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17159103&form=6&db=m New-onset hypertension and inflammatory response/poor outcome in acute ischemic stroke. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17183061&form=6&db=m Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17207628&form=6&db=m The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17218812&form=6&db=m Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220428&form=6&db=m Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17227756&form=6&db=m Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17264401&form=6&db=m Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17302065&form=6&db=m [Research on mechanism of tougu xiaotong granule in preventing and treating knee osteoarthritis] diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332756&form=6&db=m MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17344429&form=6&db=m Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17348445&form=6&db=m Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer. causal interaction,therapeutic application,unassigned 2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355261&form=6&db=m Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17360351&form=6&db=m Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363546&form=6&db=m Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17412867&form=6&db=m Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17419282&form=6&db=m Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17464354&form=6&db=m Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17487834&form=6&db=m Serum matrix metalloproteinase 7 levels identifies poor prognosis advanced colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17489740&form=6&db=m Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493236&form=6&db=m Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525740&form=6&db=m The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17556008&form=6&db=m Identification of BARD1 splice-isoforms involved in human trophoblast invasion. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17567680&form=6&db=m The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17572069&form=6&db=m Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17589947&form=6&db=m Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17591550&form=6&db=m Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609667&form=6&db=m MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17660507&form=6&db=m Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17695512&form=6&db=m HTERT mRNA expression correlates with matrix metalloproteinase-1 and vascular endothelial growth factor expression in human breast cancer: a correlative study using RT-PCR. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17729283&form=6&db=m Basigin/EMMPRIN/CD147 mediates neuron-glia interactions in the optic lamina of Drosophila. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786346&form=6&db=m Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786981&form=6&db=m HDLs activate ADAM17-dependent shedding. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17872973&form=6&db=m Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17884817&form=6&db=m Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17895241&form=6&db=m Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897672&form=6&db=m Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17904861&form=6&db=m Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17907959&form=6&db=m Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999917&form=6&db=m Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042068&form=6&db=m Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18061337&form=6&db=m ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18081311&form=6&db=m Catalytic properties of ADAM12 and its domain deletion mutants. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167337&form=6&db=m Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171715&form=6&db=m Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197923&form=6&db=m Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214300&form=6&db=m Matrix metalloproteinases 7 and 9 and their types 1 and 4 tissue inhibitors in tumors and plasma of patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18251577&form=6&db=m Hypersensitivity pneumonitis: an immunopathology review. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18260930&form=6&db=m [Activity of inflammatory-destructive changes in the process of formation of unstable atherosclerotic plaque] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261208&form=6&db=m Rosiglitazone inhibits metastasis development of a murine mammary tumor cell line LMM3. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261936&form=6&db=m A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18263696&form=6&db=m Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18265895&form=6&db=m MMP-2, TIMP-2 and CD44v6 Expression in Non-small-cell Lung Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18286531&form=6&db=m Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18293678&form=6&db=m [Endometriosis: physiopathology and investigation trends (first part)] causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18296613&form=6&db=m Tumor necrosis factor-alpha-converting enzyme (TACE) levels in periodontal diseases. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317213&form=6&db=m Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18322435&form=6&db=m Lung transplant ischemia reperfusion injury: metalloprotease inhibition down-regulates exposure of type V collagen, growth-related oncogene-induced neutrophil chemotaxis, and tumor necrosis factor-alpha expression. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18392134&form=6&db=m Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18394187&form=6&db=m Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414048&form=6&db=m Cell-surface MMP-9 regulates the invasive capacity of leukemia blast cells with monocytic features. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18419677&form=6&db=m Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18430964&form=6&db=m Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438343&form=6&db=m Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449890&form=6&db=m Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452483&form=6&db=m Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18505915&form=6&db=m Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18516293&form=6&db=m Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521441&form=6&db=m Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559520&form=6&db=m Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18582378&form=6&db=m ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18592988&form=6&db=m [Systemic inflammation in COPD and asthma: similarities and differences] diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18652863&form=6&db=m Matrix metalloprotease selective peptide substrates cleavage within hydrogel matrices for cancer chemotherapy activation. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18656632&form=6&db=m Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent. ongoing research,therapeutic application,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18690780&form=6&db=m Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18710625&form=6&db=m [Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18762577&form=6&db=m TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783335&form=6&db=m Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790755&form=6&db=m Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794108&form=6&db=m Tube travel: the role of proteases in individual and collective cancer cell invasion. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18931526&form=6&db=m In vivo Efficacy of Marimastat and Chemoradiation in Head and Neck Cancer Xenografts. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18951930&form=6&db=m AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18979631&form=6&db=m Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19008124&form=6&db=m The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010931&form=6&db=m ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015455&form=6&db=m Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19035119&form=6&db=m [Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19039945&form=6&db=m Matrix metalloproteinases 2, 3, 13 and their type 2 tissue inhibitor in tumors and plasma of patients with colorectal cancer. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19097069&form=6&db=m Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19131226&form=6&db=m The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - A mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19157913&form=6&db=m Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19207106&form=6&db=m Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19217322&form=6&db=m Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19220217&form=6&db=m Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19226458&form=6&db=m The carboxyl terminal trimer of procollagen I induces pro-metastatic changes and vascularization in breast cancer cells xenografts. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19229865&form=6&db=m The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19234364&form=6&db=m The efficacy and mechanism action of RvCSd, a new herbal agent, on immune suppression and cartilage protection in a mouse model of rheumatoid arthritis. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239642&form=6&db=m Porphyromonas gingivalis stimulates TACE production by T cells. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260128&form=6&db=m Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19273204&form=6&db=m Anthrax toxin: pathologic effects on the cardiovascular system. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19278423&form=6&db=m The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19298600&form=6&db=m Up-regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19299146&form=6&db=m Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19305382&form=6&db=m Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321579&form=6&db=m Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329328&form=6&db=m Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I). causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19332889&form=6&db=m Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19360357&form=6&db=m Three-dimensional culture using a radial flow bioreactor induces matrix metalloprotease 7-mediated EMT-like process in tumor cells via TGFbeta1/Smad pathway. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372030&form=6&db=m Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19418559&form=6&db=m Rabs and cancer cell motility. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19421039&form=6&db=m Opposite Roles of CCR2 and CX3CR1 Macrophages in Alkali-Induced Corneal Neovascularization. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19435795&form=6&db=m CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19439346&form=6&db=m Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19453649&form=6&db=m Effect of polymerized-type I collagen in knee osteoarthritis. I. In vitro study. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456279&form=6&db=m Selective MMP-12 inhibitors: WO-2008057254. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19457070&form=6&db=m Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509148&form=6&db=m Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19514131&form=6&db=m Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19528501&form=6&db=m Breast tumor cells transendothelial migration induces endothelial cell anoikis through extracellular matrix degradation. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536854&form=6&db=m Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19569245&form=6&db=m Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19601833&form=6&db=m The therapeutic potential of ADAM15. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19601834&form=6&db=m ADAM17 as a therapeutic target in multiple diseases. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19617894&form=6&db=m Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19634113&form=6&db=m E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19635101&form=6&db=m The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. causal interaction,therapeutic application,unassigned 2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638407&form=6&db=m The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19645775&form=6&db=m Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19647994&form=6&db=m Tissue inhibitor metalloproteinase type-1 (TIMP-1), a novel cancer biomarker predicting response of adjuvant anthracycline-based chemotherapy in patients afflicted with primary breast cancer. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19718658&form=6&db=m Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19747761&form=6&db=m Inflammatory Protein Serum Amyloid A1 Marks a Subset of Conventional Renal Cell Carcinomas with Fatal Outcome. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19760075&form=6&db=m Tumor Necrosis Factor Receptor Superfamily Member 21: TNFR-Related Death Receptor-6, DR6. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19769962&form=6&db=m ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794969&form=6&db=m Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804421&form=6&db=m Suppression of gastric cancer dissemination by ephrin-B1-derived peptide. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843640&form=6&db=m Abl Interactor 1 Regulates Src-Id1-Matrix Metalloproteinase 9 Axis and Is Required for Invadopodia Formation, Extracellular Matrix Degradation, and Tumor Growth of Human Breast Cancer Cells. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19847623&form=6&db=m The invasiveness of five medulloblastoma cell lines in collagen gels. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19875450&form=6&db=m Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/GP96. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896699&form=6&db=m Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19922547&form=6&db=m Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene Is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19949420&form=6&db=m Effects of biological drug adalimumab on tumour necrosis factor-alpha-converting enzyme activation. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996286&form=6&db=m ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20023698&form=6&db=m TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20062961&form=6&db=m S-nitroso-N-acetylcysteine attenuates liver fibrosis in cirrhotic rats. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20081247&form=6&db=m Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093484&form=6&db=m ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103676&form=6&db=m Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20112342&form=6&db=m ADAM28 is a serological and histochemical marker for non-small-cell lung cancers. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20156184&form=6&db=m Production of active MMP7 in E. coli and its application for metalloproteinase inhibitors screening. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20205165&form=6&db=m Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20222943&form=6&db=m Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20230216&form=6&db=m MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236691&form=6&db=m Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20303413&form=6&db=m Tumor necrosis factor-alpha converting enzyme: Implications for ocular inflammatory diseases. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20305301&form=6&db=m Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20306451&form=6&db=m Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412686&form=6&db=m The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20422344&form=6&db=m RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20467777&form=6&db=m Plasma adrenomedullin and proadrenomedullin N-terminal 20 peptide in patients diagnosed as having early rheumatoid arthritis. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20482497&form=6&db=m Recent advances in the development of MMPIs and APNIs based on the pyrrolidine platforms. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519138&form=6&db=m Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20533908&form=6&db=m Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2). causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551050&form=6&db=m Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592604&form=6&db=m Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20603312&form=6&db=m Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620173&form=6&db=m Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631638&form=6&db=m Prognostic stratification of stage IIIA pN2 non-small cell lung cancer by hierarchical clustering analysis of tissue microarray immunostaining data: an Alpe Adria Thoracic Oncology Multidisciplinary Group study (ATOM 014). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20634732&form=6&db=m Serum Monocyte Chemotactic Protein-1 Concentrations Distinguish Patients With Ankylosing Spondylitis From Patients With Mechanical Low Back Pain. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664926&form=6&db=m Expression of ADAMTS4 in Ewing's sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20682082&form=6&db=m Cetirizine a histamine H1 receptor antagonist improves viral myocarditis. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20688878&form=6&db=m Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20705134&form=6&db=m The disintegrin and metalloprotease Meltrin from Drosophila forms oligomers via its protein binding domain and is regulated by the homeobox protein VND during embryonic development. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20729277&form=6&db=m Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20826789&form=6&db=m Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20827445&form=6&db=m Expression of the PAX8/PPAR? Fusion Protein Is Associated with Decreased Neovascularization In Vivo: Impact on Tumorigenesis and Disease Prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20868478&form=6&db=m Asthma susceptible genes in Chinese population: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20871631&form=6&db=m A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20920458&form=6&db=m Comparison of metalloproteinase protein and activity profiling. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20921282&form=6&db=m Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20923324&form=6&db=m Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20946870&form=6&db=m Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1? causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20969807&form=6&db=m Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973496&form=6&db=m Dissociation Kinetics of an Enzyme-Inhibitor System Using Single-Molecule Force Measurements. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21046310&form=6&db=m Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062090&form=6&db=m Matrix Metalloproteinase Sensitive Gold Nanorod for Simultaneous Bioimaging and Photothermal Therapy of Cancer. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062896&form=6&db=m MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21064090&form=6&db=m Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21076843&form=6&db=m Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131760&form=6&db=m Biological response modifiers: current use and future prospects in cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21143201&form=6&db=m MMP9 mediates MICA shedding in human osteosarcomas. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21165404&form=6&db=m Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21171968&form=6&db=m Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21240356&form=6&db=m Clinical significance of the content of biomolecular markers in invasive front of colon carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21240381&form=6&db=m Changes in tissue metalloproteinase inhibitor-1 and matrix metalloproteinases during tumor development and metastasizing in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21244194&form=6&db=m Relationship between metalloprotease expression in tumour and stromal cells and aggressive behaviour in prostate carcinoma: Simultaneous high-throughput study of multiple metalloproteases and their inhibitors using tissue array analysis of radical prostatectomy samples. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324352&form=6&db=m Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21339346&form=6&db=m Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21389869&form=6&db=m Modulation of NKG2D-ligand Cell Surface Expression Enhances Immune Cell Therapy of Cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21415364&form=6&db=m Cross-domain inhibition of TACE ectodomain. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21429053&form=6&db=m The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21478884&form=6&db=m SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. therapeutic application,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21494182&form=6&db=m ADAM-9 expression in intestinal-type adenocarcinoma of the sinonasal tract. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21494557&form=6&db=m Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion? causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556615&form=6&db=m Expression of timp-1, timp-2, 72-kda and 92-kda type-iv collagenase transcripts in human astrocytoma cell-lines - correlation with astrocytoma cell invasiveness. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566207&form=6&db=m Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605699&form=6&db=m Initial steps of metastasis: Cell invasion and endothelial transmigration. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21612407&form=6&db=m Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21665938&form=6&db=m Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21703422&form=6&db=m Human renal cell carcinoma induces a dendritic cell subset that uses T-cell crosstalk for tumor-permissive milieu alterations. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21719449&form=6&db=m Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure? unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21724701&form=6&db=m CCL20 Stimulates Proinflammatory Mediator Synthesis in Human Fibroblast-like Synoviocytes Through a MAP Kinase-dependent Process with Transcriptional and Posttranscriptional Control. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21745518&form=6&db=m Patterns of in vitro cell-death, metaloproteinase-9 and pro-inflammatory cytokines in human monocytes induced by the BCG vaccine, Moreau strain. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21834963&form=6&db=m Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells, and mortality in obesity-resistant BALB/c mice. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880579&form=6&db=m The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21896641&form=6&db=m Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21983884&form=6&db=m Overexpression of a disintegrin and metalloprotease 8 in human gliomas is implicated in tumor progression and prognosis. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21986939&form=6&db=m A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001071&form=6&db=m Potential of fluorescent metalloproteinase substrates for cancer detection. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22020421&form=6&db=m Matrix metalloproteinase-2 promoter and tissue inhibitor of metalloproteinase-2 gene polymorphisms in non-Hodgkin's lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22067905&form=6&db=m Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22096485&form=6&db=m Enhanced activity of meprin-?, a pro-migratory and pro-angiogenic protease, in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121096&form=6&db=m MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160946&form=6&db=m Effect of Chinese drugs for activating blood circulation and detoxifying on indices of thrombosis, inflammatory reaction, and tissue damage in a rabbit model of toxin-heat and blood stasis syndrome. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22194464&form=6&db=m SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22215309&form=6&db=m Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22267082&form=6&db=m Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22270451&form=6&db=m Immunoreactivity for TIMP-2 is associated with a favorable prognosis in endometrial carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22307623&form=6&db=m Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327331&form=6&db=m Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of SGK-1. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22354570&form=6&db=m Design, characterization, and evaluation of peptide arrays allowing the direct monitoring of MMP activities. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22354764&form=6&db=m Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22363483&form=6&db=m A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22367194&form=6&db=m Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophase phagocytic activities. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22409425&form=6&db=m Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427646&form=6&db=m Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22550340&form=6&db=m TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22586143&form=6&db=m ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22586584&form=6&db=m Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22636800&form=6&db=m Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22772468&form=6&db=m Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22776555&form=6&db=m Expression and inhibition of ADAMDEC1 in craniopharyngioma cells. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22781133&form=6&db=m Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22839584&form=6&db=m [Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood]. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22882974&form=6&db=m Cell-surface Metalloprotease ADAM12 is Internalized by a Clathrin- and Grb2-dependent Mechanism. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22901175&form=6&db=m ?3GnT8 Regulates Laryngeal Carcinoma Cell Proliferation Via Targeting MMPs/TIMPs and TGF-?1. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902175&form=6&db=m ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22907434&form=6&db=m ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22908875&form=6&db=m IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923609&form=6&db=m Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22964525&form=6&db=m Matrix metalloproteinase (MMP)-2 and MMP-9 Expression in Tumor Infiltrating CD3 Lymphocytes From Women With Endometrial Cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22972310&form=6&db=m Effect of Tacrolimus on Myocardial Infarction Is Associated with Inflammation, ROS, MAP Kinase and Akt Pathways in Mini-Pigs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982189&form=6&db=m Loss of TIMP-3 Promotes Tumor Invasion via Elevated IL-6 Production and Predicts Poor Survival and Relapse in HPV-Infected Non-Small Cell Lung Cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22985699&form=6&db=m Metalloproteinase 2 and 9 activity in the development of pancreatic cancer. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23106877&form=6&db=m ADAM9 decreases in castration resistant prostate cancer and is a prognostic factor for overall survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23122666&form=6&db=m Soluble epoxide hydrolase disruption as therapeutic target for wound healing. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135915&form=6&db=m Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23142505&form=6&db=m Effects of phospholipase A2 and metalloprotease fractions of Russell's viper venom on cytokines and renal hemodynamics in dogs. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23149915&form=6&db=m Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161886&form=6&db=m ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23173124&form=6&db=m The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23242773&form=6&db=m pEGFP-N1-mediated BmK CT expression suppresses the migration of glioma. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23248767&form=6&db=m New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23248771&form=6&db=m Tumor necrosis factor ?-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23266860&form=6&db=m Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319426&form=6&db=m ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23341882&form=6&db=m ADAM17 mediates MMP9 expression in lung epithelial cells. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23342005&form=6&db=m In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361363&form=6&db=m Attenuation of increased secretory leukocyte protease inhibitor, matricellular proteins and angiotensin II and left ventricular remodeling by candesartan and omapatrilat during healing after reperfused myocardial infarction. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23423981&form=6&db=m Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis and tumor growth in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426077&form=6&db=m Cassia tora L. (Jue-ming-zi) has anticancer activity in TCA8113 cells in vitro and exerts anti-metastatic effects in vivo. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441135&form=6&db=m MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23458101&form=6&db=m ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489361&form=6&db=m In vitro method for diagnosing and monitoring renal cell carcinoma using matrix metalloprotease-7 as humoral biomarker. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23511008&form=6&db=m Gene and protein localisation of tumour necrosis factor (TNF)-? converting enzyme in gingival tissues from periodontitis patients with drug-induced gingival overgrowth. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562508&form=6&db=m ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23586783&form=6&db=m Impact of atrial fibrillation on inflammatory and fibrinolytic variables in the elderly. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23589494&form=6&db=m Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23597851&form=6&db=m New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23639813&form=6&db=m A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23681936&form=6&db=m Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684542&form=6&db=m Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23686306&form=6&db=m ADAM12-cleaved ephrin-A1 contributes to lung metastasis. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688428&form=6&db=m Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23692848&form=6&db=m The SOD mimic MnTM-2-PyP(5+) reduces hyaluronan degradation-induced inflammation in mouse articular chondrocytes stimulated with Fe (II) plus ascorbate. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23708660&form=6&db=m Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763262&form=6&db=m In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold? unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23836505&form=6&db=m Antagonistic Effects of Anti-EMMPRIN Antibody When Combined with Chemotherapy Against Hypovascular Pancreatic Cancers. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851508&form=6&db=m The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23857215&form=6&db=m CD10 is frequently expressed in classical seminomas. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23941504&form=6&db=m Identification of molecular phenotypic descriptors of breast capsular contracture formation using informatics analysis of the whole genome transcriptome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23977892&form=6&db=m In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24016393&form=6&db=m Subcurative radiation significantly increases proliferation, invasion, and migration of primary GBM in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24018643&form=6&db=m A novel orthotopic mouse model of head and neck cancer and lymph node metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24042113&form=6&db=m Periodontal treatment down-regulates protease-activated receptor-2 in human gingival crevicular fluid cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24055471&form=6&db=m ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with ?v?6 integrin. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24119788&form=6&db=m MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126638&form=6&db=m Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24145151&form=6&db=m Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24171308&form=6&db=m [Relationship between the expression levels of PAPP-A metalloproteinase and growth and transcriptional factors in endometrial cancer]. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176808&form=6&db=m Bone morphogenetic protein-7 antagonizes tumor necrosis factor-?-induced activation of nuclear factor ?B and up-regulation of the ADAMTS, leading to decreased degradation of disc matrix macromolecules aggrecan and collagen II. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184540&form=6&db=m The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24194929&form=6&db=m Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260222&form=6&db=m IL-10 inhibits the NF-?B and ERK/MAPK-mediated production of pro-inflammatory mediators by up-regulation of SOCS-3 in Trypanosoma cruzi-infected cardiomyocytes. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323769&form=6&db=m Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24361716&form=6&db=m Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24410294&form=6&db=m Impact of Parstatin on Experimental Periodontal Disease and Repair in Rats. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24444603&form=6&db=m Upregulated miR-106a plays an oncogenic role in pancreatic cancer. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24465799&form=6&db=m ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24473089&form=6&db=m Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24534253&form=6&db=m A substrate-optimized electrophoretic mobility shift assay for ADAM12. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24548418&form=6&db=m Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24553867&form=6&db=m Cardiovascular benefits of vitamin D. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24564996&form=6&db=m Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24573635&form=6&db=m Effect of hypoxia on angiogenesis related factors in glioblastoma cells. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24626788&form=6&db=m ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24646716&form=6&db=m Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24655000&form=6&db=m The Expression, Function and Targeting of Haem Oxygenase-1 in Cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24662834&form=6&db=m Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24667650&form=6&db=m ERR? signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24670536&form=6&db=m A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24759206&form=6&db=m Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24793016&form=6&db=m ADAM17 is associated with EMMPRIN and predicts poor prognosis in patients with uterine cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24798404&form=6&db=m Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24813742&form=6&db=m Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24867094&form=6&db=m Crebanine, an aporphine alkaloid, sensitizes TNF-?-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-?B-regulated gene products. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24868229&form=6&db=m Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24876675&form=6&db=m ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24896365&form=6&db=m ADAMTS-18: a metalloproteinase with multiple functions. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24941379&form=6&db=m NK cells in therapy of cancer. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25062266&form=6&db=m Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077560&form=6&db=m Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25098630&form=6&db=m Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124714&form=6&db=m ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25136829&form=6&db=m No correlation between TIMP2 -418 G>C polymorphism and increased risk of cancer: evidence from a meta-analysis. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139103&form=6&db=m EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25151965&form=6&db=m Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25171914&form=6&db=m ADAM17 at the interface between inflammation and autoimmunity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25177692&form=6&db=m A disintegrin and metalloproteinase 9 is involved in ectodomain shedding of receptor-binding cancer antigen expressed on SiSo cells. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213697&form=6&db=m miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231630&form=6&db=m Thrombin conducts epithelial?mesenchymal transition via protease?activated receptor?1 in human gastric cancer. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25250143&form=6&db=m The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25261583&form=6&db=m Biochemical and functional characterization of Bothropoidin: the first haemorrhagic metalloproteinase from Bothrops pauloensis snake venom. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25307528&form=6&db=m LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320013&form=6&db=m EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25336660&form=6&db=m N-glycosylation regulates ADAM8 processing and activation. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25407317&form=6&db=m Antiproliferative effect of the jararhagin toxin on B16F10 murine melanoma. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25438884&form=6&db=m A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹?F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25481287&form=6&db=m Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25484256&form=6&db=m MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25527274&form=6&db=m Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25608772&form=6&db=m Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25651059&form=6&db=m Transient collagen triple helix binding to a key metalloproteinase in invasion and development. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663465&form=6&db=m Questions about XY Wen et al. entitled "Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis". causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25681867&form=6&db=m On the move: endocytic trafficking in cell migration. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25704018&form=6&db=m Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25720282&form=6&db=m [Expression and activity of proteases in metastasis of ovarian cancer]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25739392&form=6&db=m Mangiferin inhibits tumor necrosis factor-?-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-?B activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25759764&form=6&db=m Association of bone loss with the upregulation of survival-related genes and concomitant downregulation of Mammalian target of rapamycin and osteoblast differentiation-related genes in the peripheral blood of late postmenopausal osteoporotic women. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25778452&form=6&db=m RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25824133&form=6&db=m Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875786&form=6&db=m An Integrated In Silico Approach for the Structural and Functional Exploration of Lipocalin 2 and its Functional Insights with Metalloproteinase 9 and Lipoprotein Receptor-Related Protein 2. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25878373&form=6&db=m Differential effects of dexamethasone and rosiglitazone in a sephadex-induced model of lung inflammation in rats: possible role of tissue inhibitor of metalloproteinase-3. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25897521&form=6&db=m Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25941780&form=6&db=m Programmed packaging of mesoporous silica nanocarriers for matrix metalloprotease 2-triggered tumor targeting and release. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25977583&form=6&db=m von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26024798&form=6&db=m Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26026583&form=6&db=m Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26056585&form=6&db=m Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironment. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26092976&form=6&db=m Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26111641&form=6&db=m Adam17, a Target of Mir-326, Promotes Emt-Induced Cells Invasion in Lung Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26130649&form=6&db=m Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26140253&form=6&db=m A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26189710&form=6&db=m Influence of an n-3 long-chain polyunsaturated fatty acid-enriched diet on experimentally induced synovitis in horses. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26254457&form=6&db=m Estrogen-deficient osteoporosis enhances the recruitment and activity of osteoclasts by breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26278714&form=6&db=m Epigallocatechin-3-gallate Increases RXR?-mediated Pro-apoptotic and Anti-invasive Effects in Gastrointestinal Cancer Cell Lines. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26327203&form=6&db=m Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26332574&form=6&db=m Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26352439&form=6&db=m 4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-? and regulating the expression of insulin signal transduction proteins. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26398940&form=6&db=m Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26407179&form=6&db=m The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26425438&form=6&db=m A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26440150&form=6&db=m Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464684&form=6&db=m Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26466547&form=6&db=m Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26488158&form=6&db=m Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26524935&form=6&db=m Correlation of Synovial Fluid Biomarkers With Cartilage Pathology and Associated Outcomes in Knee Arthroscopy. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26535007&form=6&db=m Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26583279&form=6&db=m Minocycline Inhibits Inflammation and Squamous Metaplasia of Conjunctival Tissue Culture in Airlift Conditions. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604686&form=6&db=m The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26636948&form=6&db=m Pressure and Temperature Effects on the Activity and Structure of the Catalytic Domain of Human MT1-MMP. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648423&form=6&db=m Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26711609&form=6&db=m [Expression and pathological mechanism of MMP-9 and HIF-2? in CD133(+) lung cancer stem cells]. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744411&form=6&db=m A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26815118&form=6&db=m Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-? in hepatocytes requires activation of Src and the NADPH oxidase NOX1. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26824987&form=6&db=m Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26841794&form=6&db=m ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26843424&form=6&db=m Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ?-catenin signalling and GADD45G expression. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26853425&form=6&db=m Heterozygosity of stromelysin-1 (rs3025058) promoter polymorphism is associated with gastric cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870338&form=6&db=m ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26878129&form=6&db=m In silico characterization of the interaction between LSKL peptide, a LAP-TGF-beta derived peptide, and ADAMTS1. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26899482&form=6&db=m TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26930657&form=6&db=m ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26973819&form=6&db=m Identification of Biomarkers for Footpad Dermatitis Development and Wound Healing. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27051967&form=6&db=m Myofibroblasts have an impact on expression, dimerization and signaling of different ErbB receptors in OSCC cells. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058897&form=6&db=m KDM1A promotes tumor cell invasion by silencing TIMP3 in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27060611&form=6&db=m Regulation of the ?-secretase ADAM10 at transcriptional, translational and post-translational levels. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27139570&form=6&db=m Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27179559&form=6&db=m Significance of microRNA 21 in gastric cancer. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27187039&form=6&db=m TIMP4 Modulates ER-? Signalling in MCF7 Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314162&form=6&db=m Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314542&form=6&db=m Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27356690&form=6&db=m Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27379832&form=6&db=m Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27407033&form=6&db=m Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27486337&form=6&db=m Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27487498&form=6&db=m Tumor necrosis factor-? alters integrins and metalloprotease ADAM12 levels and signaling in differentiating myoblasts. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503072&form=6&db=m An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27513359&form=6&db=m Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27521747&form=6&db=m Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27542224&form=6&db=m ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27571068&form=6&db=m ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27573075&form=6&db=m A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602775&form=6&db=m Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622031&form=6&db=m TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27652326&form=6&db=m Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27692546&form=6&db=m Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27696595&form=6&db=m Copy number profiling of tumor suppressor genes in head and neck cancer. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27731361&form=6&db=m Control of ADAM17 activity by regulation of its cellular localisation. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27764205&form=6&db=m ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27768799&form=6&db=m Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27784899&form=6&db=m Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27789071&form=6&db=m Altered Gene and Protein Expressions in Torn Rotator Cuff Tendon Tissues in Diabetic Patients. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27798872&form=6&db=m Matrix Metalloproteinase-1 Genotype Contributes to the Risk of Non-solid Tumor in Childhood Leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27861153&form=6&db=m Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27874952&form=6&db=m Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27919947&form=6&db=m High-fat Diet Enhances Mammary Tumorigenesis and Pulmonary Metastasis and Alters Inflammatory and Angiogenic Profiles in MMTV-PyMT Mice. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27956175&form=6&db=m Tumor-promoting effect of IL-23 in mammary cancer mediated by infiltration of M2 macrophages and neutrophils in tumor microenvironment. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27999200&form=6&db=m Metalloproteinase meprin ? regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056193&form=6&db=m Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28082531&form=6&db=m Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. causal interaction,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123746&form=6&db=m High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28125238&form=6&db=m Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28160627&form=6&db=m Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166590&form=6&db=m The Effect of Chrysin Loaded PLGA-PEG on Metalloproteinase Gene Expression in Mouse 4T1 Tumor Model. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28186971&form=6&db=m Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28200876&form=6&db=m Tumor Necrosis Factor-? Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28223125&form=6&db=m Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats. therapeutic application,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28233079&form=6&db=m IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-? Through the JAK-STAT Signaling Pathway. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28264989&form=6&db=m Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28282546&form=6&db=m Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28338422&form=6&db=m Therapeutic Hypothermia Reduces the Inflammatory Response Following Ischemia/Reperfusion Injury in Rat Hearts. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351385&form=6&db=m Erratum to: Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28362704&form=6&db=m Downregulation of ADAMTS18 May Serve as a Poor Prognostic Biomarker for Cervical Cancer Patients. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28395594&form=6&db=m Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28410274&form=6&db=m Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28420837&form=6&db=m Clinical Characteristics of Rheumatoid Arthritis Patients Achieving Functional Remission with Six Months of Biological DMARDs Treatment. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423710&form=6&db=m Phospholipase C?1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/?- catenin/MMP7 signalling. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454261&form=6&db=m Clinical significance of ADAM10 expression in laryngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454584&form=6&db=m Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28527916&form=6&db=m Cadmium stimulates metastasis-associated phenotype in triple-negative breast cancer cells through integrin and ?-catenin signaling. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28544932&form=6&db=m Vascular-homing peptides for cancer therapy. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28571693&form=6&db=m Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28595719&form=6&db=m Effects of carvedilol or amlodipine on target organ damage in L-NAME hypertensive rats: their relationship with blood pressure variability. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28662671&form=6&db=m Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28664988&form=6&db=m Hepatitis C virus induced tumor initiating cancer stem-like cells activate stromal fibroblasts in xenograft tumor model. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28675123&form=6&db=m ADAM9 expression promotes an aggressive lung adenocarcinoma phenotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28707770&form=6&db=m Comparison of the paracrine activity of mesenchymal stem cells derived from human umbilical cord, amniotic membrane and adipose tissue. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28723144&form=6&db=m Inflection Point of the Localized Surface Plasmon Resonance Peak: A General Method to Improve the Sensitivity. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765266&form=6&db=m ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28801789&form=6&db=m Multimodal laser ablation/desorption imaging analysis of Zn and MMP-11 in breast tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28845754&form=6&db=m Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28863997&form=6&db=m Micronized progesterone pretreatment affects the inflammatory response of human gestational tissues and the cervix to lipopolysaccharide stimulation. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28942831&form=6&db=m Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28980281&form=6&db=m Evaluating the effects of cardiac resynchronization therapy on pathophysiological pathways of heart failure using surrogate biomarkers. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28982863&form=6&db=m Effects of ADAM10 and ADAM17 Inhibitors on Natural Killer Cell Expansion and Antibody-dependent Cellular Cytotoxicity Against Breast Cancer Cells diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28988968&form=6&db=m KiSS1 gene as a novel mediator of TGF?-mediated cell invasion in triple negative breast cancer. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29026498&form=6&db=m A Case-Control Study of Comparison of Plasma Levels of Matrix Metalloproteinase-9 in Inhaled Opium Addicts and Clinically Healthy Persons. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29029414&form=6&db=m Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039509&form=6&db=m Evaluation of a novel dry eye model induced by oral administration of finasteride. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29049979&form=6&db=m Triptonide inhibits the pathological functions of gastric cancer-associated fibroblasts. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29097110&form=6&db=m Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29101167&form=6&db=m Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29131255&form=6&db=m The correlation between the expression of ADAM17, EGFR and Ki-67 in malignant gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136499&form=6&db=m Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136943&form=6&db=m ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29137479&form=6&db=m The role of the carbohydrates in plasmatic membrane. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190292&form=6&db=m TNF-? blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190883&form=6&db=m Ghrelin protects against nucleus pulposus degeneration through inhibition of NF-?B signaling pathway and activation of Akt signaling pathway. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29247327&form=6&db=m IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29256058&form=6&db=m Long-pulsed 1064-nm Nd: YAG laser ameliorates LL-37-induced rosacea-like skin lesions through promoting collagen remodeling in BALB/c mice. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29269086&form=6&db=m KISS1 tumor suppressor restricts angiogenesis of breast cancer brain metastases and sensitizes them to oncolytic virotherapy in vitro. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29285199&form=6&db=m Overexpression of ADAM9 in oral squamous cell carcinoma. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29358859&form=6&db=m Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453336&form=6&db=m Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29523216&form=6&db=m MiR-148b functions as a tumor suppressor by targeting endoplasmic reticulum metallo protease 1 in human endometrial cancer cells. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29561011&form=6&db=m Hypotoxic copper complexes with potent anti-metastatic and anti-angiogenic activities against cancer cells. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29638194&form=6&db=m The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease. diagnostic usage,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693120&form=6&db=m MicroRNA?122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in vitro. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29860265&form=6&db=m Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872742&form=6&db=m Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29917063&form=6&db=m Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29921495&form=6&db=m Low levels of ADAM23 expression in epithelial ovarian cancer are associated with poor survival. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29926003&form=6&db=m Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29927319&form=6&db=m Dietary Fat Stimulates Pancreatic Cancer Growth and Promotes Fibrosis of the Tumor Microenvironment through the Cholecystokinin Receptor. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928319&form=6&db=m Canine mammary tumors as a model for human disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29934628&form=6&db=m PROX1 is a transcriptional regulator of MMP14. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29949791&form=6&db=m LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29985410&form=6&db=m Optimization of a MT1-MMP-targeting Peptide and Its Application in Near-infrared Fluorescence Tumor Imaging. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30024495&form=6&db=m Clinical significance of matrix metalloproteinase-2 in endometrial cancer: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30052775&form=6&db=m MMP23B expression and protein levels in blood and urine are associated with bladder cancer. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30102333&form=6&db=m Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127323&form=6&db=m Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30190423&form=6&db=m Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30226539&form=6&db=m Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine?disrupting chemicals. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265671&form=6&db=m Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30352908&form=6&db=m Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30359513&form=6&db=m The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30361787&form=6&db=m Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30371220&form=6&db=m ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30431071&form=6&db=m Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review). causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450736&form=6&db=m Engineering of TIMP-3 as a LAP-fusion protein for targeting to sites of inflammation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30464505&form=6&db=m ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546831&form=6&db=m A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30556643&form=6&db=m ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30569855&form=6&db=m Nanotherapy Targeting the Tumor Microenvironment. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30599075&form=6&db=m MicroRNA-21-5p are involved in apoptosis and invasion of fibroblast-like synoviocytes through PTEN/PI3K/AKT signal. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30603552&form=6&db=m In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30634456&form=6&db=m A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30638183&form=6&db=m Interleukin-32: Frenemy in cancer? therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655735&form=6&db=m Novel role of microRNA-126 in digestive system cancers: From bench to bedside. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30721587&form=6&db=m Up-regulation of the MicroRNA miR-30c Induced by High Mobility Group Box 1 in A549 Cells Used as an Alveolar Epithelial Model. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30730845&form=6&db=m Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30747385&form=6&db=m Decreased MMP1 gene expression in acute myeloid leukaemia. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30781538&form=6&db=m Circadian Expression of TIMP3 Is Disrupted by UVB Irradiation and Recovered by Green Tea Extracts. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30792164&form=6&db=m MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30815959&form=6&db=m A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842824&form=6&db=m In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30856553&form=6&db=m Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30881675&form=6&db=m Macrocyclisation of small peptides enabled by oxetane incorporation. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30959928&form=6&db=m The Importance of the Knee Joint Meniscal Fibrocartilages as Stabilizing Weight Bearing Structures Providing Global Protection to Human Knee-Joint Tissues. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30992230&form=6&db=m The metalloprotease ADAM17 in inflammation and cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142630&form=6&db=m Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival. diagnostic usage,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31196220&form=6&db=m Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31200666&form=6&db=m A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31202209&form=6&db=m The Potential Role of Medicinal Plants in Bone Regeneration. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31219020&form=6&db=m Integrated Metalloproteinase, pH and Glutathione Responsive Prodrug-Based Nanomedicine for Efficient Target Chemotherapy. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31292722&form=6&db=m Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31294335&form=6&db=m The role of ADAMTS-13 and von Willebrand factor in cancer patients: Results from the Vienna Cancer and Thrombosis Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31342542&form=6&db=m MMP11 expression in intratumoral inflammatory cells in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31365784&form=6&db=m SRC fine-tunes ADAM10 shedding activity to promote pituitary adenoma cell progression. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31444237&form=6&db=m Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-?. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31463899&form=6&db=m Inhibition of ADAMTS1 Expression by Lentiviral CRISPR/Cas9 Gene Editing Technology. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31499120&form=6&db=m Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-?/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31588243&form=6&db=m TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31604138&form=6&db=m In vitro anti-inflammatory properties of Smilax campestris aqueous extract in human macrophages, and characterization of its flavonoid profile. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31651714&form=6&db=m Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31662485&form=6&db=m iRhom2 and TNF: Partners or enemies? unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31685773&form=6&db=m A Novel TNF-? Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31918067&form=6&db=m Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32028690&form=6&db=m Regulation of MT1-MMP Activity through Its Association with ERMs. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32060096&form=6&db=m ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1). unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32063906&form=6&db=m Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32068254&form=6&db=m DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32073014&form=6&db=m Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-?B signaling pathway in vivo and in vitro. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32102222&form=6&db=m Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32117229&form=6&db=m Modulation of Immune Responses by Platelet-Derived ADAM10. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32161544&form=6&db=m Scutellarin Attenuates the IL-1?-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32162384&form=6&db=m Teneligliptin inhibits IL-1?-induced degradation of extracellular matrix in human chondrocytes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32217157&form=6&db=m A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32260433&form=6&db=m Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32291412&form=6&db=m The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis. causal interaction,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319541&form=6&db=m LRP6 is involved in the proliferation, migration and invasion of trophoblast cells via miR?346. diagnostic usage,ongoing research,unassigned 2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32397419&form=6&db=m Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, Crotalus atrox. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32408377&form=6&db=m Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506851&form=6&db=m Three Tiaobu Feishen formulae reduces cigarette smoke-induced inflammation in human airway epithelial cells. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32575507&form=6&db=m Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32586242&form=6&db=m A knock-down cell-based study for the functional analysis of chloride intracellular channel 1 (CLIC1): Integrated proteomics and microarray study. diagnostic usage,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32637415&form=6&db=m ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-?B Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32669083&form=6&db=m Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32683175&form=6&db=m Insights and perspectives on calcium channel functions in the cockpit of cancerous space invaders. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32772139&form=6&db=m Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793313&form=6&db=m Identification of potential crucial genes associated with the pathogenesis and prognosis of pancreatic adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32817921&form=6&db=m Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32831881&form=6&db=m An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863948&form=6&db=m Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32875951&form=6&db=m Structure, regulatory factors and cancer-related physiological effects of ADAM9. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32884571&form=6&db=m Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer. causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32906814&form=6&db=m Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32911849&form=6&db=m iRhom2: An Emerging Adaptor Regulating Immunity and Disease. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32972437&form=6&db=m Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006373&form=6&db=m The tissue-renin-angiotensin-system of the human intervertebral disc. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043016&form=6&db=m Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of ?-Catenin, BRG1, and KDM4. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33143292&form=6&db=m Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33149866&form=6&db=m Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152052&form=6&db=m Toxicodendron vernicifluum Stokes extract inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176868&form=6&db=m Analysis of ADAM9 regulation and function in vestibular schwannoma primary cells. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33213419&form=6&db=m Joint hemorrhage accelerates cartilage degeneration in a rat immobilized knee model. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233485&form=6&db=m Infection with Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Human Cholangiocytes. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277582&form=6&db=m The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus. ongoing research,therapeutic application,unassigned 2,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33294270&form=6&db=m Resveratrol-mediated ADAM9 degradation decreases cancer progression and provides synergistic effects in combination with chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33426683&form=6&db=m Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469545&form=6&db=m The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513131&form=6&db=m Modeling invasion patterns in the glioblastoma battlefield. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531871&form=6&db=m A preliminary study: is fibulin 1 a friend or an enemy that needs to be silenced with siRNAs for mesothelioma? causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33548228&form=6&db=m The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer. ongoing research,unassigned 2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33573342&form=6&db=m Skin Immunomodulation during Regeneration: Emerging New Targets. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637565&form=6&db=m In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33673639&form=6&db=m Discovery and Optimization of Selective Inhibitors of Meprin ? (Part II). causal interaction,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805447&form=6&db=m Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811456&form=6&db=m Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33846772&form=6&db=m TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated metastasis of chemoresistant colon cancer cells. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921267&form=6&db=m ADAMTS19 Suppresses Cell Migration and Invasion by Targeting S100A16 via the NF-?B Pathway in Human Gastric Cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33931579&form=6&db=m DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells. causal interaction,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937253&form=6&db=m Targeting the Urotensin II/UT G Protein-Coupled Receptor to Counteract Angiogenesis and Mesenchymal Hypoxia/Necrosis in Glioblastoma. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33957124&form=6&db=m Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34012098&form=6&db=m Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055644&form=6&db=m Combined Radiochemotherapy: Metalloproteinases Revisited. therapeutic application,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34067041&form=6&db=m ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease. ongoing research,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34110633&form=6&db=m Hypoxia-Inducible Exosomes Facilitate Liver-Tropic Premetastatic Niche in Colorectal Cancer. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34152937&form=6&db=m The blood-brain and gut-vascular barriers: from the perspective of claudins. ongoing research,unassigned 4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34166113&form=6&db=m Allogenic Pure Platelet-Rich Plasma Therapy for Adhesive Capsulitis: A Bed-to-Bench Study With Propensity Score Matching Using a Corticosteroid Control Group. therapeutic application,unassigned 1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34166375&form=6&db=m Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34224305&form=6&db=m Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3? axis. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34250755&form=6&db=m mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1-MMP Endocytosis Arrest. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34324950&form=6&db=m Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target? causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360807&form=6&db=m Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer. ongoing research,unassigned 3,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402747&form=6&db=m In-silico evidence of ADAM metalloproteinase pathology in cancer signaling networks. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34408201&form=6&db=m Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1. unassigned - 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34513052&form=6&db=m Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34519970&form=6&db=m Modulation of peritumoral fibroblasts with a membrane-tethered tissue inhibitor of metalloproteinase (TIMP) for the elimination of cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.4.24.77 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723234&form=6&db=m Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. causal interaction,ongoing research,unassigned 2,3,0 3.4.24.77 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626598&form=6&db=m Macrophage metalloelastase as a major factor for glomerular injury in anti-glomerular basement membrane nephritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.24.77 Nephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27706571&form=6&db=m Effects of Shenkangling intervention on the MAPK pathway in rats with doxorubicin-induced nephropathy. unassigned - 3.4.24.77 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712219&form=6&db=m Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11464705&form=6&db=m [The role of metalloprotease in pathogenesis of nervous system diseases] causal interaction,unassigned 4,0 3.4.24.77 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454584&form=6&db=m Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9406876&form=6&db=m A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19523695&form=6&db=m Matrix metalloprotease regulation of neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20218929&form=6&db=m Therapeutic potential of matrix metalloprotease inhibitors in neuropathic pain. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24093749&form=6&db=m Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28169407&form=6&db=m Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Neuroacanthocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17379193&form=6&db=m The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system. unassigned - 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8780892&form=6&db=m Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines. ongoing research,unassigned 4,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9574753&form=6&db=m TBJ murine neuroblastoma resists dibutyryl cyclic AMP-induced differentiation and effects on metalloproteinase secretion. ongoing research,unassigned 3,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9673346&form=6&db=m Two new human neuroblastoma cell lines exhibiting tumorigenesis and metastasis in the nude mouse model. ongoing research,unassigned 4,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10389972&form=6&db=m A comparative study of the effects of genistein and 2-methoxyestradiol on the proteolytic balance and tumour cell proliferation. ongoing research,unassigned 2,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10877999&form=6&db=m Tandem duplication. A novel type of triplet repeat instability. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11107133&form=6&db=m Association between favorable neuroblastoma and high expression of the novel metalloproteinase gene, nbla3145/XCE, cloned by differential screening of the full-length-enriched oligo-capping neuroblastoma cDNA libraries. unassigned - 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11168376&form=6&db=m Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11928813&form=6&db=m Platelet activating factor inhibits the expression of matrix metalloproteinases and affects invasiveness and differentiation in a system of human neuroblastoma clones. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12670874&form=6&db=m Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. ongoing research,unassigned 2,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12749850&form=6&db=m Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site. therapeutic application,unassigned 2,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801775&form=6&db=m Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin ?1; ADAP1) in neuroblastoma cells. causal interaction,unassigned 2,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21972134&form=6&db=m Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-?1 (ADAP1). ongoing research,unassigned 2,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23257508&form=6&db=m Carnosic acid suppresses the production of amyloid-? 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084684&form=6&db=m Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation. ongoing research,unassigned 4,0 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29867502&form=6&db=m Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis. unassigned - 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33208450&form=6&db=m ADAM15 Participates in Tick-Borne Encephalitis Virus Replication. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.24.77 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33556560&form=6&db=m Phenanthroline impairs ?APP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.24.77 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15580619&form=6&db=m Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. unassigned - 3.4.24.77 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661359&form=6&db=m Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. causal interaction,unassigned 3,0 3.4.24.77 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19161911&form=6&db=m Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. ongoing research,unassigned 2,0 3.4.24.77 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23413979&form=6&db=m Roles of endoproteolytic ?-cleavage and shedding of the prion protein in neurodegeneration. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31054542&form=6&db=m Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31184526&form=6&db=m An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A. unassigned - 3.4.24.77 Neuroectodermal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8780892&form=6&db=m Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines. ongoing research,unassigned 4,0 3.4.24.77 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8611434&form=6&db=m Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17082642&form=6&db=m Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.24.77 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19161911&form=6&db=m Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. ongoing research,unassigned 2,0 3.4.24.77 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323769&form=6&db=m Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27734023&form=6&db=m Selected CSF biomarkers indicate no evidence of early neuroinflammation in Huntington disease. ongoing research,unassigned 2,0 3.4.24.77 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30075790&form=6&db=m Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 3.4.24.77 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31172218&form=6&db=m MMPs and ADAMs in neurological infectious diseases and multiple sclerosis. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590698&form=6&db=m A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient. unassigned - 3.4.24.77 Neuroma, Acoustic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176868&form=6&db=m Analysis of ADAM9 regulation and function in vestibular schwannoma primary cells. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12859620&form=6&db=m The 'Abtropfung phenomenon' revisited: Dermal nevus cells from congenital nevi cannot activate matrix metalloproteinase 2 (MMP-2). causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19766963&form=6&db=m Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24254368&form=6&db=m The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. diagnostic usage,unassigned 1,0 3.4.24.77 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24978432&form=6&db=m Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs). therapeutic application,unassigned 1,0 3.4.24.77 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29912573&form=6&db=m Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12529376&form=6&db=m Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. causal interaction,unassigned 4,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288749&form=6&db=m Proinflammatory adipocytokines induce TIMP-1 expression in 3T3-L1 adipocytes. causal interaction,unassigned 4,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731796&form=6&db=m Tissue inhibitor of metalloproteinase 1 expression and secretion are induced by beta-adrenergic stimulation in 3T3-L1 adipocytes. causal interaction,unassigned 4,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23010875&form=6&db=m ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23478427&form=6&db=m Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study. causal interaction,unassigned 3,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707750&form=6&db=m Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice. ongoing research,unassigned 4,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26993223&form=6&db=m Hydrogen Sulfide Depletion Contributes to Microvascular Remodeling in Obesity. causal interaction,unassigned 3,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28430139&form=6&db=m The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751722&form=6&db=m Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28911167&form=6&db=m In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice. causal interaction,unassigned 4,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29658577&form=6&db=m Interleukin 29 activates expression of tissue inhibitor of metalloproteinase 1 in macrophages via toll?like receptor 2. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075797&form=6&db=m Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity. causal interaction,unassigned 4,0 3.4.24.77 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516010&form=6&db=m [Effect of the management of class I obesity with metformin on metalloproteinase activity in patients with chronic periodontitis]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758506&form=6&db=m Effect of the putative novel selective ETA-receptor antagonist HJP272, a 1,3,6-trisubstituted-2-carboxy-quinol-4-one, on infection-mediated premature delivery. therapeutic application,unassigned 4,0 3.4.24.77 Ocular Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26956170&form=6&db=m Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Odontogenic Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24974940&form=6&db=m Collagenase-3 expression in periapical lesions: an immunohistochemical study. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Odontogenic Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31319505&form=6&db=m HIF-1? is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1? and NOTCH1 Signaling Pathways. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Onycholysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479963&form=6&db=m [The blood biochemical indicators as possible markers of destruction of kerato-hyaline tissue of nails in patients with onycholysis]. ongoing research,unassigned 2,0 3.4.24.77 Opportunistic Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1506780&form=6&db=m Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.77 Optic Atrophy, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30174613&form=6&db=m Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue. causal interaction,unassigned 1,0 3.4.24.77 Optic Nerve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342670&form=6&db=m Metalloproteinase 9 and TIMP-1 expression in retina and optic nerve in absolute angle closure glaucoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Optic Nerve Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445745&form=6&db=m Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma. ongoing research,unassigned 3,0 3.4.24.77 Optic Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24283430&form=6&db=m Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1581627&form=6&db=m Regulation of metalloproteinase gene expression: implications for osteoarthritis. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662722&form=6&db=m Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase. therapeutic application,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168825&form=6&db=m The effect of recombinant tumor necrosis factor-alpha on superoxide and metalloproteinase production by synovial cells and chondrocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3305939&form=6&db=m Levels of metalloproteases and tissue inhibitor of metalloproteases in human osteoarthritic cartilage. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575725&form=6&db=m Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8015285&form=6&db=m Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8053958&form=6&db=m Prostromelysin and procollagenase genes are differentially up-regulated in chondrocytes from the knees of rabbits with experimental osteoarthritis. ongoing research,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8496867&form=6&db=m Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8731393&form=6&db=m Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8866331&form=6&db=m Immunological detection of type II collagen degradation: use in the evaluation of anti-arthritic therapies. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8886087&form=6&db=m Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids. diagnostic usage,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150082&form=6&db=m The therapeutic effects of tenidap in canine experimental osteoarthritis: relationship with biochemical markers. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9536826&form=6&db=m Basic calcium phosphate crystals induce synthesis and secretion of 92 kDa gelatinase (gelatinase B/matrix metalloprotease 9) in human fibroblasts. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639100&form=6&db=m Cytokine inducible matrix metalloproteinase expression in immortalized rat chondrocytes is independent of nitric oxide stimulation. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10415731&form=6&db=m Clinical trials of a stromelysin inhibitor. Osteoarthritis, matrix metalloproteinase inhibition, cartilage loss, surrogate markers, and clinical implications. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10643716&form=6&db=m Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10765924&form=6&db=m Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11060752&form=6&db=m Metalloproteinase inhibitors: new opportunities for the treatment of rheumatoid arthritis and osteoarthritis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592366&form=6&db=m Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966774&form=6&db=m Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. ongoing research,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202125&form=6&db=m Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. ongoing research,unassigned 4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14579524&form=6&db=m Design strategies for the identification of MMP-13 and Tace inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161923&form=6&db=m ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15320727&form=6&db=m The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE. therapeutic application,unassigned 4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15818704&form=6&db=m Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507124&form=6&db=m Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16759884&form=6&db=m Changes in immunolocalisation of beta-dystroglycan and specific degradative enzymes in the osteoarthritic synovium. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16859525&form=6&db=m Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. causal interaction,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210251&form=6&db=m Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2). therapeutic application,unassigned 4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17305507&form=6&db=m Molecular targets in osteoarthritis: metalloproteinases and their inhibitors. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17949675&form=6&db=m Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963739&form=6&db=m Naproxen, meloxicam and methylprednisolone inhibit urokinase plasminogen activator and inhibitor and gelatinases expression during the early stage of osteoarthritis. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17975844&form=6&db=m Effects of different molecular weight hyaluronan products on the expression of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18541144&form=6&db=m Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice. causal interaction,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456279&form=6&db=m Selective MMP-12 inhibitors: WO-2008057254. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684582&form=6&db=m Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19765281&form=6&db=m Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19909832&form=6&db=m 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. ongoing research,unassigned 4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19915594&form=6&db=m Modulating hedgehog signaling can attenuate the severity of osteoarthritis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067755&form=6&db=m Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110528&form=6&db=m Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process. ongoing research,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592604&form=6&db=m Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome. causal interaction,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21223960&form=6&db=m Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM-Increased serum CIIM in subjects with severe radiographic osteoarthritis. ongoing research,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21418601&form=6&db=m Intra-articular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21913037&form=6&db=m Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation of pro-matrix metalloproteinase (MMP)-13. ongoing research,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22247346&form=6&db=m Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis. ongoing research,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22469853&form=6&db=m Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22676306&form=6&db=m The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22891645&form=6&db=m Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT). causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22997976&form=6&db=m Levels of metalloproteinase (MMP-3, MMP-9), NF-kappaB ligand (RANKL), and nitric oxide (NO) in peripheral blood of osteoarthritis (OA) patients. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23132541&form=6&db=m Phosphorylation of osteopontin in osteoarthritis degenerative cartilage and its effect on matrix metalloprotease 13. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23716507&form=6&db=m Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23938376&form=6&db=m Potent inhibitors precise to S1' loop of MMP-13, a crucial target for osteoarthritis. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126638&form=6&db=m Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24251351&form=6&db=m Notch signaling is involved in human articular chondrocytes de-differentiation during osteoarthritis. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24279019&form=6&db=m [Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis]. therapeutic application,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24303940&form=6&db=m WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24474687&form=6&db=m Low-density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4: Functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding. causal interaction,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24576742&form=6&db=m Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595230&form=6&db=m Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25009588&form=6&db=m Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro. ongoing research,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25045124&form=6&db=m Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes. causal interaction,unassigned 4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25219668&form=6&db=m Intra-articular administration of xenogeneic neonatal Mesenchymal Stromal Cells early after meniscal injury down-regulates metalloproteinase gene expression in synovium and prevents cartilage degradation in a rabbit model of osteoarthritis. causal interaction,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25687637&form=6&db=m Pyrroloquinoline Quinone Slows Down the Progression of Osteoarthritis by Inhibiting Nitric Oxide Production and Metalloproteinase Synthesis. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693634&form=6&db=m CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25784380&form=6&db=m Biologic basis of osteoarthritis: state of the evidence. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26162802&form=6&db=m SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26288689&form=6&db=m Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT). causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303525&form=6&db=m Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2). causal interaction,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26612259&form=6&db=m Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2). causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26657033&form=6&db=m Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26818776&form=6&db=m VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27067395&form=6&db=m The IL-1?/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27122313&form=6&db=m Interaction of HIF1? and ?-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27401455&form=6&db=m Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27449198&form=6&db=m Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27855162&form=6&db=m ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28120109&form=6&db=m Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28139355&form=6&db=m Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. therapeutic application,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28216310&form=6&db=m ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28223125&form=6&db=m Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats. therapeutic application,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29102725&form=6&db=m Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29241192&form=6&db=m MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1?-Induced Catabolism in Human Articular Chondrocytes. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29441864&form=6&db=m Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes. therapeutic application,unassigned 4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29563338&form=6&db=m An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29890416&form=6&db=m Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-?B and Wnt/?-catenin signaling in-vitro and in-vivo. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29983942&form=6&db=m Guava leaf extract suppresses osteoarthritis progression in a rat anterior cruciate ligament transection model. causal interaction,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30210670&form=6&db=m Diagnostic utility of fluorogenic peptide-conjugated Au nanoparticle probe corroborated by rabbit model of mild cartilage injury and panel of osteoarthritic patients. ongoing research,unassigned 2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30536194&form=6&db=m The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis. diagnostic usage,therapeutic application,unassigned 4,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30815381&form=6&db=m Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30942091&form=6&db=m Salicin inhibits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31215422&form=6&db=m Hyaluronan derivative HYMOVIS® increases cartilage volume and type ii collagen turnover in osteoarhritic knee: data from MOKHA study. causal interaction,unassigned 1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31395181&form=6&db=m Evaluating the Effects of Platelet-Rich Plasma and Amniotic Viscous Fluid on Inflammatory Markers in a Human Coculture Model for Osteoarthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31415758&form=6&db=m Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31463904&form=6&db=m Purification and Activity Determination of ADAMTS-4 and ADAMTS-5 and Their Domain Deleted Mutants. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32003758&form=6&db=m Nesfatin-1 suppresses interleukin-1?-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32349389&form=6&db=m Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1?-induced Primary Human Articular Chondrocytes. causal interaction,unassigned 4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32772139&form=6&db=m Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. causal interaction,unassigned 3,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381768&form=6&db=m Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33480322&form=6&db=m The alteration of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in the knee joints of osteoarthritis mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34190732&form=6&db=m Correction to: Relationship Between Magnetic Resonance T2-Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis. unassigned - 3.4.24.77 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34500490&form=6&db=m Osteoblasts Regulate the Expression of ADAMTS and MMPs in Chondrocytes through ERK Signaling Pathway. unassigned - 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122138&form=6&db=m Expression changes of gelatinases in human osteoarthritic knees and arthroscopic debridement. ongoing research,unassigned 2,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16200596&form=6&db=m Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17299841&form=6&db=m Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinase expression via 3 mitogen-activated protein kinases and PI3K pathways during the early development of osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996201&form=6&db=m Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23578941&form=6&db=m The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24583346&form=6&db=m Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients. ongoing research,unassigned 1,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501175&form=6&db=m Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29231368&form=6&db=m [Repair effects of close-to-bone needing combined with electroacupuncture on extracellular matrix of cartilage in rabbits with knee osteoarthritis]. ongoing research,unassigned 3,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29701048&form=6&db=m [Mechanism of thermosensitive moxibustion on knee osteoarthritis in rabbit models]. ongoing research,unassigned 2,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266746&form=6&db=m Relationship between ADAMTS14/rs4747096 gene polymorphism and knee osteoarthritis in Chinese population. diagnostic usage,unassigned 3,0 3.4.24.77 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32490633&form=6&db=m The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis therapeutic application,unassigned 1,0 3.4.24.77 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9678031&form=6&db=m Matrix metalloproteinases and tissue inhibitors of metalloproteinases in loose artificial hip joints. causal interaction,unassigned 3,0 3.4.24.77 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24373848&form=6&db=m Microenvironmental stimuli affect Endothelin-1 signaling responsible for invasiveness and osteomimicry of bone metastasis from breast cancer. causal interaction,unassigned 1,0 3.4.24.77 Osteomalacia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12791601&form=6&db=m FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. ongoing research,unassigned 1,0 3.4.24.77 Osteomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23768487&form=6&db=m Staphylococcus aureus osteomyelitis: bad to the bone. unassigned - 3.4.24.77 Osteonecrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514432&form=6&db=m Expression profile of matrix metalloproteinase-2 and -9 and their endogenous tissue inhibitors in osteonecrotic femoral heads. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Osteopetrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33451291&form=6&db=m Multi-trait GWAS using imputed high-density genotypes from whole-genome sequencing identifies genes associated with body traits in Nile tilapia. unassigned - 3.4.24.77 Osteophyte http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32831881&form=6&db=m An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7472745&form=6&db=m Osteosarcoma oncogene expression detected by in situ hybridization. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8275936&form=6&db=m Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis. ongoing research,unassigned 3,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8608972&form=6&db=m Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in co-culture of human osteosarcoma cells and human fibroblasts: gelatinase B production was stimulated via up-regulation of fibroblast growth factor (FGF) receptor. ongoing research,unassigned 4,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10359049&form=6&db=m Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10374843&form=6&db=m Overexpression of matrix metalloproteinase (MMP)-9 correlates with metastatic potency of spontaneous and 4-hydroxyaminoquinoline 1-oxide (4-HAQO)-induced transplantable osteosarcomas in rats. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14704980&form=6&db=m Gene expression changes in BALB/3T3 transformants induced by poly(L-lactic acid) or polyurethane films. therapeutic application,unassigned 1,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15929722&form=6&db=m Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor. ongoing research,unassigned 3,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560840&form=6&db=m ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing. ongoing research,unassigned 4,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22215309&form=6&db=m Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24356192&form=6&db=m Differential expression of degradome components in cutaneous squamous cell carcinomas. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24449508&form=6&db=m Letter regarding Wen X.Y. et al. entitled "Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis" diagnostic usage,unassigned 1,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24752352&form=6&db=m IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway. ongoing research,unassigned 2,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25481287&form=6&db=m Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663465&form=6&db=m Questions about XY Wen et al. entitled "Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis". causal interaction,unassigned 2,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26466547&form=6&db=m Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180. ongoing research,unassigned 4,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30936722&form=6&db=m Elevated expression of microRNA-328-3p suppresses aggressive malignant behaviors via targeting matrix metalloprotease 16 in osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030108&form=6&db=m Cas9 Protein Triggers Differential Expression of Inherent Genes Especially NGFR Expression in 293T Cells. ongoing research,unassigned 1,0 3.4.24.77 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32377334&form=6&db=m The anti-neoplastic effect of doxycycline in osteosarcoma as a metalloproteinase (MMP) inhibitor: a systematic review. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.77 Otitis Media http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12897557&form=6&db=m Alpha 1-antitrypsin and ilomastat inhibit inflammatory proteases present in human middle ear effusions. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Otitis Media http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14520103&form=6&db=m Protease inhibitors alpha1-antitrypsin and ilomastat are not ototoxic in the chinchilla. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Out-of-Hospital Cardiac Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27610586&form=6&db=m Decreased a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 activity and neurologic outcome in patients with successful resuscitation of out-of-hospital cardiac arrest: A prospective observational study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7806000&form=6&db=m Type-IV collagenase and tissue inhibitor of metalloproteinase in ovarian cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9743290&form=6&db=m Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor (MMPSF). causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10050107&form=6&db=m The matrix metalloprotease pump-1 (MMP-7, Matrilysin): A candidate marker/target for ovarian cancer detection and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10416010&form=6&db=m The metalloproteinase inhibitor batimastat (BB-94) causes cell cycle phase perturbations in ovarian cancer cells. therapeutic application,unassigned 2,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11063654&form=6&db=m Expression of various matrix proteases and Ets family transcriptional factors in ovarian cancer cell lines: correlation to invasive potential. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331272&form=6&db=m Functional interplay between type I collagen and cell surface matrix metalloproteinase activity. causal interaction,unassigned 3,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11872628&form=6&db=m Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11935494&form=6&db=m [New aspects by the therapy of ovarian cancer--What changes after the ASCO-Meeting 2001] causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491751&form=6&db=m Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171715&form=6&db=m Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20070123&form=6&db=m Combinatorial peptide libraries facilitate development of multiple reaction monitoring assays for low-abundance proteins. diagnostic usage,unassigned 3,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20649989&form=6&db=m CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion. therapeutic application,unassigned 1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21165404&form=6&db=m Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21239435&form=6&db=m Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22511598&form=6&db=m Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients. ongoing research,unassigned 1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23423981&form=6&db=m Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis and tumor growth in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26214617&form=6&db=m The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer. ongoing research,unassigned 1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27888810&form=6&db=m M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29042458&form=6&db=m Exenatide modulates tumor-endothelial cell interactions in human ovarian cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30583672&form=6&db=m Molecular Targeting of Notch Signaling Pathway by DAPT in Human Ovarian Cancer: Possible Anti Metastatic Effects ongoing research,unassigned 4,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30947122&form=6&db=m Thiophenol-formaldehyde triazole causes apoptosis induction in ovary cancer cells and prevents tumor growth formation in mice model. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31793719&form=6&db=m Aberrant expression of ADAM9 in ovarian cancer and its clinical significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32851734&form=6&db=m Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.4.24.77 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34240668&form=6&db=m Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33803785&form=6&db=m Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8611434&form=6&db=m Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10357914&form=6&db=m Matrix metalloproteinase inhibition suppresses MMP-2 activity and activation of PANC-1 cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14669788&form=6&db=m Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15910719&form=6&db=m TIMP-1 antisense gene transfection attenuates the invasive potential of pancreatic cancer cells in vitro and inhibits tumor growth in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545513&form=6&db=m Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171715&form=6&db=m Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18319621&form=6&db=m Gamma-Irradiation Enhances RECK Protein Levels in Panc-1 Pancreatic Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22064652&form=6&db=m MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22985699&form=6&db=m Metalloproteinase 2 and 9 activity in the development of pancreatic cancer. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23752129&form=6&db=m M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24526468&form=6&db=m Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression. ongoing research,unassigned 4,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25566991&form=6&db=m CD44 regulates pancreatic cancer invasion through MT1-MMP. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26440150&form=6&db=m Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26782265&form=6&db=m NS?398 promotes pancreatic cancer cell invasion by CD147 and MMP?2 via the activation of P38. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28514751&form=6&db=m Large-scale clinical validation of biomarkers for pancreatic cancer using a mass spectrometry-based proteomics approach. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30171263&form=6&db=m L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression. causal interaction,unassigned 2,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31402756&form=6&db=m Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis. ongoing research,unassigned 2,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32048249&form=6&db=m Propofol affects the growth and metastasis of pancreatic cancer via ADAM8. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32325664&form=6&db=m Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression? causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32637415&form=6&db=m ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-?B Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9260202&form=6&db=m The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitis. diagnostic usage,unassigned 3,0 3.4.24.77 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18929380&form=6&db=m Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19515067&form=6&db=m Hypertonic Saline Reduces Metalloproteinase Expression In Liver During Pancreatitis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731158&form=6&db=m [The matrix metalloproteinase 9 (MMP-9) and TIMP-1 activities in patients with chronic and recurrent pancreatitis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763262&form=6&db=m In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold? unassigned - 3.4.24.77 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8611434&form=6&db=m Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9598809&form=6&db=m Prolyl hydroxylase and tissue inhibitor of metalloproteinase in pure pancreatic juice in patients with chronic pancreatitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626132&form=6&db=m Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22516424&form=6&db=m The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.77 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30571080&form=6&db=m Covalent modifiers of Botulinum neurotoxin counteract toxin persistence. therapeutic application,unassigned 1,0 3.4.24.77 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31771110&form=6&db=m Tables of Toxicity of Botulinum and Tetanus Neurotoxins. causal interaction,unassigned 2,0 3.4.24.77 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635427&form=6&db=m Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. causal interaction,unassigned 3,0 3.4.24.77 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549317&form=6&db=m Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein. ongoing research,unassigned 4,0 3.4.24.77 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18076378&form=6&db=m Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential. ongoing research,unassigned 2,0 3.4.24.77 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20208537&form=6&db=m Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. causal interaction,unassigned 2,0 3.4.24.77 Paraproteinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197802&form=6&db=m DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356520&form=6&db=m In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Parathyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23001705&form=6&db=m Biomarkers of parathyroid carcinoma. ongoing research,unassigned 1,0 3.4.24.77 Paratuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8577260&form=6&db=m Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Pemphigoid, Bullous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11710917&form=6&db=m Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Periapical Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912382&form=6&db=m Sonic extracts from a bacterium related to periapical disease activate gelatinase A and inactivate tissue inhibitor of metalloproteinases TIMP-1 and TIMP-2. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Perinatal Death http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16671095&form=6&db=m A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383501&form=6&db=m Expression of collagenase and potential transcriptional factors c-fos and egr-1 in periodontal gingival fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17122880&form=6&db=m The effects of the initial treatment phase and of adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in the saliva and peripheral blood of patients with chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22612366&form=6&db=m Elevated Levels of A Disintegrin and Metalloproteinase 8 in Gingival Crevicular Fluid of Patients With Periodontal Diseases. diagnostic usage,unassigned 4,0 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23360525&form=6&db=m Periodontal disease and gene-expression levels of metalloendopeptidases in human buccal mucosal epithelium. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26538900&form=6&db=m Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28898418&form=6&db=m Matrix metalloproteinase-8 levels in periodontal disease patients: A systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556465&form=6&db=m Presence of mast cells and the expression of metalloproteinase 9 in the gingiva of ovariectomized rats with periodontal disease. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516010&form=6&db=m [Effect of the management of class I obesity with metformin on metalloproteinase activity in patients with chronic periodontitis]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Periodontal Pocket http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996292&form=6&db=m Chlamydia pneumoniae together with collagenase-2 (MMP-8) in periodontal lesions. causal interaction,therapeutic application,unassigned 2,2,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12747454&form=6&db=m Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26132583&form=6&db=m Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease). causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26209620&form=6&db=m A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System. ongoing research,unassigned 2,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26932322&form=6&db=m Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27139570&form=6&db=m Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases. ongoing research,unassigned 3,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553143&form=6&db=m Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31020669&form=6&db=m A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32932898&form=6&db=m Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.77 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33459718&form=6&db=m Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease. ongoing research,unassigned 1,0 3.4.24.77 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15606382&form=6&db=m Abnormal circulating levels of metalloprotease 9 and its tissue inhibitor 1 in angiographically proven peripheral arterial disease: relationship to disease severity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2 3.4.24.77 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614002&form=6&db=m Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28637396&form=6&db=m Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.4.24.77 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21782897&form=6&db=m Different expression of tissue inhibitor of metalloproteinase family members in rat dorsal root ganglia and their changes after peripheral nerve injury. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28261743&form=6&db=m LLLT actives MMP-2 and increases muscle mechanical resistance after nerve sciatic rat regeneration. ongoing research,therapeutic application,unassigned 3,2,0 3.4.24.77 Peritoneal Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233528&form=6&db=m The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats. ongoing research,unassigned 4,0 3.4.24.77 Peritoneal Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31579944&form=6&db=m Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 3.4.24.77 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16684893&form=6&db=m Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224788&form=6&db=m Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.77 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1374477&form=6&db=m Differentiation of PC12 cells with nerve growth factor is associated with induction of transin synthesis and release. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12670874&form=6&db=m Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. ongoing research,unassigned 2,0 3.4.24.77 Pick Disease of the Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661359&form=6&db=m Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. causal interaction,unassigned 3,0 3.4.24.77 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12114792&form=6&db=m Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Pituitary Adenomas: Possible Markers of Neuroendocrine Cells. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.77 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136943&form=6&db=m ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 plasmin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10469644&form=6&db=m Functional overlap between two classes of matrix-degrading proteases in wound healing. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Pleural Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202798&form=6&db=m Tissue inhibitor of metalloproteinase 2 (TIMP-2) expression in adenocarcinoma pleural effusions. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Pleural Effusion, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20230924&form=6&db=m On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. diagnostic usage,unassigned 3,0 3.4.24.77 Pneumococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21098102&form=6&db=m Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice. ongoing research,therapeutic application,unassigned 1,2,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1371528&form=6&db=m Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica. causal interaction,unassigned 1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8926116&form=6&db=m The dsbB gene product is required for protease production by Burkholderia cepacia. unassigned - 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419836&form=6&db=m Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide. ongoing research,unassigned 4,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956209&form=6&db=m Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein. unassigned - 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12864860&form=6&db=m Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863246&form=6&db=m Repeated cadmium nebulizations induce pulmonary MMP-2 and MMP-9 production and emphysema in rats. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947421&form=6&db=m Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487958&form=6&db=m Environmental arsenic exposure and sputum metalloproteinase concentrations. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18379252&form=6&db=m Establishment of a young mouse model and identification of an allelic variation of zmpB in complicated pneumonia caused by Streptococcus pneumoniae. unassigned - 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519138&form=6&db=m Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21388634&form=6&db=m Pathology, Tissue Metalloproteinase Transcription and Haptoglobin Responses in Mice after Experimental Challenge with Different Isolates of Pasteurella multocida Obtained from Cases of Porcine Pneumonia. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21804454&form=6&db=m Grape skin extract reduced pulmonary oxidative response in mice exposed to cigarette smoke. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22712283&form=6&db=m [The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases]. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23181168&form=6&db=m 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24342803&form=6&db=m Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24833351&form=6&db=m Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25480335&form=6&db=m ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26086425&form=6&db=m ApolipoproteinA-1 Overexpression Attenuates Cigarette Smoke Induced Emphysema in Mice. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26641856&form=6&db=m Angiotensin-(1-7)/Mas Signaling Inhibits Lipopolysaccharide-Induced ADAM17 Shedding Activity and Apoptosis in Alveolar Epithelial Cells. causal interaction,unassigned 4,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28596294&form=6&db=m The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation. ongoing research,unassigned 1,0 3.4.24.77 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33443926&form=6&db=m Marked von Willebrand factor and factor VIII elevations in severe acute respiratory syndrome coronavirus-2-positive, but not severe acute respiratory syndrome coronavirus-2-negative, pneumonia: a case-control study. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 3.4.24.77 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181417&form=6&db=m A possible role for metalloproteinases in renal cyst development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27374915&form=6&db=m The epidermal growth factor receptor pathway in chronic kidney diseases. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31990681&form=6&db=m Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 3.4.24.77 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27374915&form=6&db=m The epidermal growth factor receptor pathway in chronic kidney diseases. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31990681&form=6&db=m Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 3.4.24.77 Polycystic Kidney, Autosomal Recessive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576338&form=6&db=m A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.24.77 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28598286&form=6&db=m Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29086015&form=6&db=m The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.24.77 Polycythemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31310562&form=6&db=m Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation: Mechanistic Implications for Desquamative Interstitial Pneumonitis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Polycythemia Vera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Polymicrogyria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718938&form=6&db=m Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. unassigned - 3.4.24.77 Polyneuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27588448&form=6&db=m Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369868&form=6&db=m Increased proteolytic activity and matrix metalloprotease expression in lungs during infection by porcine reproductive and respiratory syndrome virus. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24965453&form=6&db=m Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27174637&form=6&db=m Correction for Guo et al., Modulation of CD163 Expression by Metalloprotease ADAM17 Regulates Porcine Reproductive and Respiratory Syndrome Virus Entry. unassigned - 3.4.24.77 Prader-Willi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19159951&form=6&db=m Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7479614&form=6&db=m Increased immunohistochemical expression of neutral metalloendopeptidase (enkephalinase; EC 3.4.24.11) in villi of the human placenta with pre-eclampsia. ongoing research,unassigned 2,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15994630&form=6&db=m Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522398&form=6&db=m First-trimester trophoblast cell model gene response to hypoxia. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18477480&form=6&db=m Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18978109&form=6&db=m First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022799&form=6&db=m Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20840693&form=6&db=m First-trimester placental protein 13 and placental growth factor: markers for identification of women destined to develop early-onset pre-eclampsia. diagnostic usage,unassigned 2,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21512165&form=6&db=m Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21769110&form=6&db=m Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327101&form=6&db=m Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22357350&form=6&db=m The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,4 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22676623&form=6&db=m Metalloprotease (ADAM12-S) as a Predictor of Preeclampsia: Correlation with Severity, Maternal Complications, Fetal Outcome, and Doppler Parameters. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172037&form=6&db=m Promoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese population. causal interaction,therapeutic application,unassigned 2,2,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23703536&form=6&db=m Downregulated Kruppel-Like Factor 8 Is Involved in Decreased Trophoblast Invasion Under Hypoxia-Reoxygenation Conditions. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23980220&form=6&db=m Efficiency of first-trimester uterine artery Doppler, a-disintegrin and metalloprotease 12, pregnancy-associated plasma protein a, and maternal characteristics in the prediction of preeclampsia. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105301&form=6&db=m OS087. Maternal characteristics, mean arterial pressure and PLGF in early prediction of preeclampsia. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26304100&form=6&db=m Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317342&form=6&db=m Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363034&form=6&db=m Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29135310&form=6&db=m ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29670668&form=6&db=m Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. causal interaction,unassigned 1,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1407560&form=6&db=m Endopeptidase-24.11 is suppressed in myelin-forming but not in non-myelin-forming Schwann cells during development of the rat sciatic nerve. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660144&form=6&db=m CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1717072&form=6&db=m CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation. therapeutic application,unassigned 1,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760013&form=6&db=m Neutral endopeptidase modulation of septic shock. causal interaction,unassigned 1,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8356064&form=6&db=m Inhibition of CD10/neutral endopeptidase 24.11 promotes B-cell reconstitution and maturation in vivo. therapeutic application,unassigned 1,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8602728&form=6&db=m Neutral endopeptidase modulates septic shock. therapeutic application,unassigned 1,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031085&form=6&db=m Can CD10 be used as a diagnostic marker in thyroid pathology? unassigned - 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748669&form=6&db=m In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24586463&form=6&db=m Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo. unassigned - 3.4.24.77 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21625236&form=6&db=m Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Pregnancy, Ectopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11042903&form=6&db=m Immunohistochemical expression of matrix metalloproteinases 1 and 2 (MMP-1 and MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in ruptured and non-ruptured tubal ectopic pregnancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Pregnancy, Ectopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21277576&form=6&db=m A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.77 Pregnancy, Ectopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21392752&form=6&db=m Disintegrin and metalloprotease and ectopic pregnancy. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Pregnancy, Ectopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830297&form=6&db=m Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8108184&form=6&db=m Tissue inhibitor of metalloproteinase-1 mRNA is specifically induced in lung tissue after birth. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30730845&form=6&db=m Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies. unassigned - 3.4.24.77 Primary Myelofibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12437648&form=6&db=m Plasma matrix metalloproteinase and tissue inhibitor of metalloproteinase in patients with agnogenic myeloid metaplasia or idiopathic primary myelofibrosis. ongoing research,unassigned 2,0 3.4.24.77 Primary Myelofibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16109602&form=6&db=m Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia. causal interaction,unassigned 4,0 3.4.24.77 Primary Myelofibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23484726&form=6&db=m [Research progress on mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia]. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30583769&form=6&db=m Association between tissue inhibitor of metalloproteinase (TIMP) genetic polymorphisms and primary ovarian insufficiency (POI). causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24771043&form=6&db=m Apparent Reduction of ADAM10 in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.77 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25654651&form=6&db=m The sheddase ADAM10 is a potent modulator of prion disease. causal interaction,unassigned 4,0 3.4.24.77 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625583&form=6&db=m Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein. unassigned - 3.4.24.77 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322316&form=6&db=m Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22103512&form=6&db=m Cell autonomous and systemic factors in progeria development. causal interaction,unassigned 4,0 3.4.24.77 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23539603&form=6&db=m The structural basis of ZMPSTE24-dependent laminopathies. therapeutic application,unassigned 1,0 3.4.24.77 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23695662&form=6&db=m Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23917225&form=6&db=m Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29567411&form=6&db=m Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS). therapeutic application,unassigned 1,0 3.4.24.77 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31312666&form=6&db=m Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice. ongoing research,unassigned 1,0 3.4.24.77 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8712742&form=6&db=m Immunohistochemical evaluation of type IV collagenase (72-kd metalloproteinase) in prostatic intraepithelial neoplasia. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716536&form=6&db=m Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin. diagnostic usage,unassigned 1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848860&form=6&db=m Expression of metalloproteinase genes in human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8859777&form=6&db=m Evidence for increased activated metalloproteinase 2 (MMP-2a) expression associated with human prostate cancer progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485497&form=6&db=m Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. causal interaction,unassigned 3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10544294&form=6&db=m Promatrilysin expression is induced by fibroblast growth factors in the prostatic carcinoma cell line LNCaP but not in normal primary prostate epithelial cells. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861487&form=6&db=m Synthetic inhibitor of matrix metalloproteases decreases tumor growth and metastases in a syngeneic model of rat prostate cancer in vivo. causal interaction,unassigned 4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477554&form=6&db=m Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640098&form=6&db=m Prognostic significance of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14695147&form=6&db=m The role of an 80 kDa fragment of E-cadherin in the metastatic progression of prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734484&form=6&db=m Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15046708&form=6&db=m Antimetastatic drugs in prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467730&form=6&db=m CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. unassigned - 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15832061&form=6&db=m Cerebral ischemic events in patients with advanced lung or prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967115&form=6&db=m Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942404&form=6&db=m Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. ongoing research,unassigned 2,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18061337&form=6&db=m ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18196535&form=6&db=m Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18612129&form=6&db=m Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19207106&form=6&db=m Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19229865&form=6&db=m The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20101234&form=6&db=m Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. causal interaction,unassigned 3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590445&form=6&db=m Androgen regulates ADAMTS15 gene expression in prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732728&form=6&db=m PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9. ongoing research,unassigned 3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20949559&form=6&db=m Herpesvirus saimiri (HVS)-based endothelin converting enzyme-1 (ECE-1) shRNA expression decreases prostate cancer cell invasion and migration. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22765866&form=6&db=m Collagen I and III and metalloproteinase gene and protein expression in prostate cancer in relation to Gleason score. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22781133&form=6&db=m Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23286446&form=6&db=m Combined Dynamic Alterations in Urinary VEGF Levels and Tissue ADAM9 Expression as Markers for Lethal Phenotypic Progression of Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23830872&form=6&db=m Integrin ?7 Binds Tissue Inhibitor of Metalloproteinase 3 to Suppress Growth of Prostate Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24564996&form=6&db=m Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25218471&form=6&db=m Amyloid precursor protein regulates migration and metalloproteinase gene expression in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25239421&form=6&db=m Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence. diagnostic usage,unassigned 1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543229&form=6&db=m Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26689510&form=6&db=m Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells. ongoing research,unassigned 4,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26912236&form=6&db=m Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27749584&form=6&db=m Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28161070&form=6&db=m Metalloproteinase 11, potential marker and molecular target in advanced and castration-resistant prostate cancer. Culture study of peritumoral fibroblasts. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28282546&form=6&db=m Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31013576&form=6&db=m Identification of ADAM12 as a Novel Basigin Sheddase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31499120&form=6&db=m Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-?/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31874825&form=6&db=m Design and synthesis of a novel BODIPY-labeled PSMA inhibitor. causal interaction,unassigned 3,0 3.4.24.77 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186519&form=6&db=m Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.77 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777440&form=6&db=m Effects of aging and castration on plasminogen activator and metalloprotease activities in the rat prostate complex. causal interaction,unassigned 1,0 3.4.24.77 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18725420&form=6&db=m ZapA, a virulence factor in a rat model of Proteus mirabilis-induced acute and chronic prostatitis. ongoing research,unassigned 2,0 3.4.24.77 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8915963&form=6&db=m Angiotensin in progressive renal diseases: theory and practice. causal interaction,unassigned 3,0 3.4.24.77 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19090960&form=6&db=m Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21471190&form=6&db=m Distinct actions of ETA selective versus combined ETA/ETB receptor antagonists in early diabetic kidney disease. diagnostic usage,unassigned 3,0 3.4.24.77 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25087615&form=6&db=m Ureic clearance granule, alleviates renal dysfunction and tubulointerstitial fibrosis by promoting extracellular matrix degradation in renal failure rats, compared with enalapril. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269827&form=6&db=m ADAM33 as a Psoriasis Susceptibility Gene in the Han Population of Northeastern China. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24574341&form=6&db=m Targeting miR-21 to treat psoriasis. causal interaction,unassigned 3,0 3.4.24.77 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27857980&form=6&db=m Cutaneous Expression of A Disintegrin-like and Metalloprotease domain containing Thrombospondin Type 1 motif-like 5 (ADAMTSL5) in Psoriasis goes beyond Melanocytes. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28482118&form=6&db=m Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes. unassigned - 3.4.24.77 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14578390&form=6&db=m UVB-elicited induction of MMP-1 expression in human ocular surface epithelial cells is mediated through the ERK1/2 MAPK-dependent pathway. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9659544&form=6&db=m Gelatinolytic activity in tracheal epithelial lining fluid and in blood from horses with chronic obstructive pulmonary disease. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10712992&form=6&db=m Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11471571&form=6&db=m All trans-retinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740239&form=6&db=m [Markers of airway remodeling in induced sputum from healthy smokers] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16919984&form=6&db=m Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17090574&form=6&db=m A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146995&form=6&db=m An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403951&form=6&db=m DNA sequence variations of metalloproteinases: their role in asthma and COPD. causal interaction,unassigned 3,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410963&form=6&db=m The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19160802&form=6&db=m [Effects of Shenqi Bufei Tang on expessions of NF-kappaB, MMP-9 and TIMP-1 in airway remodeling of COPD rat model with lung-Qi deficiency syndrome] causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19278250&form=6&db=m A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408). causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21861887&form=6&db=m Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22153340&form=6&db=m Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22209925&form=6&db=m Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22574591&form=6&db=m [Effects of shuxuening injection on the levels of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in acute exacerbated chronic obstructive pulmonary disease patients]. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22712283&form=6&db=m [The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases]. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773692&form=6&db=m Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22888638&form=6&db=m [Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962063&form=6&db=m In Utero Exposure to Second-Hand-Smoke (SHS) Aggravates Adult Responses to Irritants: I. Adult SHS. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23012495&form=6&db=m Serological investigation of the collagen degradation profile of patients with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23228114&form=6&db=m Specific IgA and metalloproteinase activity in bronchial secretions from stable chronic obstructive pulmonary disease patients colonized by Haemophilus influenzae. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359665&form=6&db=m A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect via NF-?B Inhibition. ongoing research,unassigned 4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24422987&form=6&db=m Polymorphisms in a disintegrin and metalloprotease 33 gene and the risk of chronic obstructive pulmonary disease: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24555057&form=6&db=m Comparison of arterial and venous blood biomarker levels in chronic obstructive pulmonary disease. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25158257&form=6&db=m Association of a disintegrin and metalloproteinase 33 (ADAM33) gene polymorphisms with chronic obstructive pulmonary disease in the Chinese population: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25280544&form=6&db=m Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25983406&form=6&db=m A disintegrin and metalloprotease 33 polymorphism association with COPD in long-term tobacco smokers of the ethnic Kashmiri population of India. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27078193&form=6&db=m Genetic Variants in IL6R and ADAM19 are Associated with COPD Severity in a Mexican Mestizo Population. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27890988&form=6&db=m Variability in proteinase-antiproteinase balance, nutritional status, and quality of life in stable chronic obstructive pulmonary disease due to tobacco and nontobacco etiology. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28429897&form=6&db=m Single nucleotide polymorphisms V4 and T1 of the ADAM33 gene in Venezuelan patients with asthma or chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29255356&form=6&db=m Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501846&form=6&db=m Quantitative proteomic characterization of the lung extracellular matrix in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. causal interaction,unassigned 2,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29750543&form=6&db=m A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29864380&form=6&db=m A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30429371&form=6&db=m Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357020&form=6&db=m Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32610835&form=6&db=m Sputum Inflammometry to Manage Chronic Obstructive Pulmonary Disease Exacerbations: Beyond Guidelines. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32690871&form=6&db=m A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33181031&form=6&db=m ADAM17 Deficiency Protects against Pulmonary Emphysema. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33198714&form=6&db=m Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.24.77 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34402290&form=6&db=m [Study on effect of anemoside B4 in improving COPD rats by regulating IL-12/STAT4 and IL-4/STAT6 signaling pathways]. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23991023&form=6&db=m Polymorphisms of the Tissue Inhibitor of Metalloproteinase 3 Gene Are Associated with Resistance to High-Altitude Pulmonary Edema (HAPE) in a Japanese Population: A Case Control Study Using Polymorphic Microsatellite Markers. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20890187&form=6&db=m Metalloproteinase inhibition protects against cardiomyocyte injury during experimental acute pulmonary thromboembolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.24.77 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27090654&form=6&db=m Evaluation of Pregnancy-Associated Plasma Protein-A Levels in Patients with Chronic Obstructive Pulmonary Disease and Associations with Disease Severity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31438579&form=6&db=m Isolation of a Novel Metalloproteinase from Agkistrodon Venom and Its Antithrombotic Activity Analysis. causal interaction,unassigned 2,0 3.4.24.77 Pulmonary Emphysema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16240598&form=6&db=m [Occupational exposure to respiratory irritants and chronic obstructive pulmonary disease] causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Pulmonary Emphysema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19456279&form=6&db=m Selective MMP-12 inhibitors: WO-2008057254. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Pulmonary Emphysema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21057003&form=6&db=m The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema. causal interaction,unassigned 3,0 3.4.24.77 Pulmonary Emphysema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28251446&form=6&db=m Atorvastatin and Simvastatin Promoted Mouse Lung Repair After Cigarette Smoke-Induced Emphysema. causal interaction,unassigned 3,0 3.4.24.77 Pulmonary Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625177&form=6&db=m Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. causal interaction,unassigned 3,0 3.4.24.77 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10201943&form=6&db=m Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11555678&form=6&db=m Role of MMP-2 in alveolar epithelial cell repair after bleomycin administration in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11983918&form=6&db=m Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555446&form=6&db=m [The changes of expression level of matrix metalloprotease 9 and its inhibitor (TIMP-1) in murine pulmonary fibrosis model] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25997387&form=6&db=m Suppressor of cytokine signaling 1-modulated metalloproteinases and tissue inhibitor of metalloproteinase in pulmonary fibrosis. causal interaction,unassigned 3,0 3.4.24.77 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30915776&form=6&db=m MiR-34b-5p knockdown attenuates bleomycin-induced pulmonary fibrosis by targeting tissue inhibitor of metalloproteinase 3 (TIMP3). causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.24.77 Purpura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022799&form=6&db=m Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Purpura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152183&form=6&db=m DRESS syndrome and thrombotic thrombocytopaenic purpura: are they related? ongoing research,unassigned 1,0 3.4.24.77 Purpura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25623397&form=6&db=m Long-term remission of recurrent thrombotic thrombocytopenic purpura (TTP) after rituximab in children and young adults. causal interaction,unassigned 2,0 3.4.24.77 Purpura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31283011&form=6&db=m Emerging roles of adjunct therapies in acquired thrombotic thrombocytopenia purpura. causal interaction,unassigned 3,0 3.4.24.77 Purpura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31585956&form=6&db=m Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events. unassigned - 3.4.24.77 Purpura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34352748&form=6&db=m Effectiveness of Caplacizumab Nanobody in Acquired Thrombotic Thrombocytopenic Purpura Refractory to Conventional Treatment. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15774620&form=6&db=m ADAMTS13 turns 3. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Purpura, Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21531732&form=6&db=m ADAMTS13--more than just TMA and TTP. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombocytopenic, Idiopathic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751717&form=6&db=m A successfully treated case of an acute presentation of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) with decreased ADAMTS13 during late stage of pregnancy. diagnostic usage,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10819702&form=6&db=m Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine-associated thrombotic thrombocytopenic purpura. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11074544&form=6&db=m High titers of inhibitors of von Willebrand factor-cleaving metalloproteinase in a fatal case of acute thrombotic thrombocytopenic purpura. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11328948&form=6&db=m von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11535519&form=6&db=m Decreased von Willebrand factor protease activity associated with thrombocytopenic disorders. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11557746&form=6&db=m Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11675345&form=6&db=m Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105394&form=6&db=m The genetics and pathogenesis of haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura. diagnostic usage,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12378548&form=6&db=m Acute thrombotic thrombocytopenic purpura following orthopedic surgery. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421153&form=6&db=m Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. diagnostic usage,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12590947&form=6&db=m Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12605663&form=6&db=m Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura. causal interaction,diagnostic usage,unassigned 2,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12775718&form=6&db=m ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12858075&form=6&db=m An update on the pathogenesis and management of acquired thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14727255&form=6&db=m Cleavage of von Willebrand factor by ADAMTS-13 on endothelial cells. diagnostic usage,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14982878&form=6&db=m Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15045144&form=6&db=m An enzyme immunoassay of ADAMTS13 distinguishes patients with thrombotic thrombocytopenic purpura from normal individuals and carriers of ADAMTS13 mutations. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15890682&form=6&db=m ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15916687&form=6&db=m The course of ADAMTS-13 activity and inhibitor titre in the treatment of thrombotic thrombocytopenic purpura with plasma exchange and vincristine. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16141351&form=6&db=m Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167049&form=6&db=m The role of ADAMTS13 in the pathogenesis of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16201838&form=6&db=m Current concepts in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16388412&form=6&db=m Thrombotic thrombocytopenic purpura: a diagnostic and therapeutic challenge. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409158&form=6&db=m Current concepts in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525809&form=6&db=m Acute thrombotic thrombocytopenic purpura following orthopedic surgery: a case report. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627268&form=6&db=m Rituximab can be combined with daily plasma exchange to achieve effective B-cell depletion and clinical improvement in acute autoimmune TTP. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755777&form=6&db=m [Hereditary form of thrombotic thrombocytopenic purpura] causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16796708&form=6&db=m Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797677&form=6&db=m Decreased ADAMTS13 activity in plasma from patients with thrombotic thrombocytopenic purpura. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16807643&form=6&db=m A common origin of the 4143insA ADAMTS13 mutation. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16931205&form=6&db=m Recurrent idiopathic thrombotic thrombocytopenic purpura: a role for vaccination in disease relapse? unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17058049&form=6&db=m Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17367414&form=6&db=m The clinical utility of ADAMTS13 activity, antigen and autoantibody assays in thrombotic thrombocytopenic purpura. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17426255&form=6&db=m An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897672&form=6&db=m Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains. ongoing research,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17900666&form=6&db=m ADAMTS13 related markers and von Willebrand factor in plasma from patients with thrombotic microangiopathy (TMA). diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18341632&form=6&db=m The VWF/ADAMTS13 axis in the antiphospholipid syndrome: ADAMTS13 antibodies and ADAMTS13 dysfunction. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528825&form=6&db=m Rapid quantitative assay of ADAMTS13 activity on an automated coagulation analyzer: clinical applications and comparison with immunoblot method. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18574602&form=6&db=m Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957966&form=6&db=m Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18981290&form=6&db=m N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18988930&form=6&db=m Linear relationship between ADAMTS13 activity and platelet dynamics even before severe thrombocytopenia. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19085767&form=6&db=m Von Willebrand factor: another janus-faced hemostasis protein. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19180123&form=6&db=m Mechanisms of microvascular thrombosis in thrombotic thrombocytopenic purpura. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19215624&form=6&db=m An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584892&form=6&db=m Reduced ADAMTS13 activity in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630717&form=6&db=m Potential role of ADAMTS13 in the progression of alcoholic hepatitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19654870&form=6&db=m Characterization of conformation-sensitive antibodies to ADAMTS13, the von Willebrand cleavage protease. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19784542&form=6&db=m Rituximab was effective on refractory thrombotic thrombocytopenic purpura but induced a flare of hemophagocytic syndrome in a patient with systemic lupus erythematosus. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20391298&form=6&db=m Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20628891&form=6&db=m Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20701734&form=6&db=m An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21196718&form=6&db=m ADAMTS-13 antigen and activity levels in thrombocytopenic disorders including thrombotic thrombocytopenic purpura in Kuwait. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21657946&form=6&db=m Investigational drugs in thrombotic thrombocytopenic purpura. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022775&form=6&db=m Thrombotic Thrombocytopenic Purpura and Anti-Thrombotic Therapy Targeted to Von Willebrand Factor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22265954&form=6&db=m Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22289888&form=6&db=m Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22374533&form=6&db=m [Exacerbation of cranial nerurological symptoms by platelet transfusion before the diagnosis of thrombotic thrombocytopenic purpura]. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22378676&form=6&db=m Congenital Thrombotic Thrombocytopenic Purpura Associated With Moyamoya Syndrome in a 3-Year-Old Girl: A Case Report. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22529289&form=6&db=m A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22611154&form=6&db=m Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22765161&form=6&db=m Autopsy case of sudden maternal death from thrombotic thrombocytopenic purpura. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22879435&form=6&db=m Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23410558&form=6&db=m Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23420593&form=6&db=m Thrombotic thrombocytopenic purpura-what is new? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23422353&form=6&db=m Thrombotic thrombocytopenic purpura in children. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620569&form=6&db=m Presenting ADAMTS13 on a TTP-associated MHC. ongoing research,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23803463&form=6&db=m Fatal hemolytic uremic syndrome associated with day care surgery and anaesthesia: a case report. diagnostic usage,unassigned 2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23813910&form=6&db=m ADAMTS13 content in plasma-derived factor VIII/von Willebrand factor concentrates. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23899959&form=6&db=m Immature platelet fraction can help adjust therapy in refractory thrombotic microangiopathic hemolytic anemia cases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24033710&form=6&db=m Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073552&form=6&db=m Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis. diagnostic usage,therapeutic application,unassigned 4,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669560&form=6&db=m Clinical experience in treatment of thrombotic thrombocytopenic purpura--hemolytic uremic syndrome with 28 patients. therapeutic application,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753113&form=6&db=m Cocaine-induced microangiopathic hemolytic anemia mimicking idiopathic thrombotic thrombocytopenic purpura: A case report and review of the literature. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816970&form=6&db=m Inherited thrombotic thrombocytopenic purpura in children. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339550&form=6&db=m Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura. ongoing research,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25377323&form=6&db=m Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25442981&form=6&db=m The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice. ongoing research,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25503977&form=6&db=m VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26081109&form=6&db=m Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26203127&form=6&db=m High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26260740&form=6&db=m Thrombotic thrombocytopenic purpura during pregnancy versus imitator of preeclampsia. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26272487&form=6&db=m The D173G mutation in ADAMTS-13 causes a severe form of congenital thrombotic thrombocytopenic purpura. A clinical, biochemical andin silico study. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26276936&form=6&db=m Thrombosis, Microangiopathies, and Inflammation. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342041&form=6&db=m ADAMTS13 Secretion and Residual Activity among Patients with Congenital Thrombotic Thrombocytopenic Purpura with and without Renal Impairment. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26359646&form=6&db=m The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry. diagnostic usage,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26581428&form=6&db=m ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637781&form=6&db=m What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26720166&form=6&db=m N-Acetylcysteine for Relapsing Thrombotic Thrombocytopenic Purpura: More Evidence of a Promising Drug. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26747250&form=6&db=m CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26779871&form=6&db=m Rituximab-refractory thrombotic thrombocytopenic purpura responsive to intravenous but not subcutaneous bortezomib. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27009919&form=6&db=m Bortezomib in the treatment of refractory thrombotic thrombocytopenic purpura. causal interaction,unassigned 2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27132698&form=6&db=m Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27479501&form=6&db=m Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720178&form=6&db=m Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28279966&form=6&db=m Plasmin Cleaves Von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Manner In Vitro. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28367342&form=6&db=m Remission of Severe, Relapsed, and Refractory TTP after Multiple Cycles of Bortezomib. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28380082&form=6&db=m Heparin-induced thrombocytopenia as a cause of prolonged low platelet count in a patient with thrombotic thrombocytopenic purpura treated with plasmapheresis. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28635017&form=6&db=m Clinical features and outcomes in patients with thrombotic microangiopathy not associated with severe ADAMTS13 deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751567&form=6&db=m The ADAMTS13(1239-1253) peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759473&form=6&db=m Novel therapeutic approaches for thrombotic thrombocytopenic purpura. ongoing research,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28768626&form=6&db=m Pathophysiology of thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29554699&form=6&db=m Genetic and Functional Characterization of ADAMTS13 Variants in a Patient Cohort with Upshaw-Schulman Syndrome Investigated in Germany. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29771863&form=6&db=m Upshaw-Schulman Syndrome With c.2728C>T Mutation in ADAMTS13 Gene. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29920743&form=6&db=m Identification of a crucial tryptophan residue in ADAMTS13 required for its secretion and enzymatic activity. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942494&form=6&db=m Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency. diagnostic usage,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30235478&form=6&db=m Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30235483&form=6&db=m Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354235&form=6&db=m Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30394580&form=6&db=m ADAMTS13 kinetics after therapeutic plasma exchange and plasma infusion in patients with Upshaw-Schulman syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447150&form=6&db=m Chest pain with increased troponin level; not always a cardiology issue. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30586332&form=6&db=m Correction to: Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30919938&form=6&db=m Comparison of Rituximab originator (MabThera) to biosimilar (Truxima) in patients with immune-mediated thrombotic thrombocytopenic purpura. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30928346&form=6&db=m Thrombotic Thrombocytopenic Purpura: Beyond Empiricism and Plasma Exchange. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930238&form=6&db=m Inherited Thrombotic Thrombocytopenic Purpura Revealed by Recurrent Strokes in a Male Adult: Case Report and Literature Review. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944043&form=6&db=m Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31198222&form=6&db=m Atypical hemolytic uremic syndrome: a syndrome in need of clarity. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31249957&form=6&db=m Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31250841&form=6&db=m Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423067&form=6&db=m Novel Heterozygous Mutations of Congenital Thrombotic Thrombocytopenic Purpura: A Rare Case Report. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31587247&form=6&db=m Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31624623&form=6&db=m Presumed antiphospholipid syndrome and thrombotic thrombocytopenic purpura: An infrequent association. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708547&form=6&db=m Thrombotic Thrombocytopenic Purpura Treated with Rituximab Associated with Primary Sjögren's Syndrome and Primary Hypothyroidism. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31753928&form=6&db=m Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor. causal interaction,unassigned 2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32095224&form=6&db=m Caplacizumab in adult patients with acquired thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32187046&form=6&db=m Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239643&form=6&db=m A multi-center evaluation of TECHNOSCREEN® ADAMTS-13 activity assay as a screening tool for detecting deficiency of ADAMTS-13. diagnostic usage,ongoing research,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32300446&form=6&db=m Aggressive Disease and Rare Sequelae in a Unique Case of Atypical Hemolytic Uremic Syndrome Secondary to Adult Onset Still's Disease. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411562&form=6&db=m Thrombotic Thrombocytopenic Purpura Masquerading as Acute Ischemic Stroke. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32507820&form=6&db=m [Diagnosis and treatment of thrombotic thrombocytopenic purpura]. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32598743&form=6&db=m [Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions]. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32740038&form=6&db=m Insights into ADAMTS13 structure: impact on thrombotic thrombocytopenic purpura diagnosis and management. ongoing research,unassigned 2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33096882&form=6&db=m The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33124748&form=6&db=m A multicenter laboratory assessment of a new automated chemiluminescent assay for ADAMTS13 activity. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33184803&form=6&db=m Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura. ongoing research,unassigned 2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33221124&form=6&db=m Successful management of three patients with autoimmune thrombotic thrombocytopenic purpura with paradigm-changing therapy: Caplacizumab, steroids, plasma exchange, rituximab, and intravenous immunoglobulins (CASPERI). unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537532&form=6&db=m Diagnosis and follow-up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33552303&form=6&db=m [Thrombotic microangiopathy]. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33728786&form=6&db=m Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33834592&form=6&db=m A human monoclonal antibody against the distal carboxyl terminus of ADAMTS-13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33841853&form=6&db=m Thrombotic microangiopathies assessment: mind the complement. causal interaction,unassigned 3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33914240&form=6&db=m Double positivity of anti-?2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody. ongoing research,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984867&form=6&db=m Plasma Levels of Big Endothelin-1 Are Associated with Renal Insufficiency and In-Hospital Mortality of Immune Thrombotic Thrombocytopenic Purpura. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34105490&form=6&db=m [Biological Function of CysR Domain of ADAMTS13]. ongoing research,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34113115&form=6&db=m Unresponsive Thrombotic Thrombocytopenic Purpura (TTP): Challenges and Solutions. causal interaction,unassigned 4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34219357&form=6&db=m Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34267062&form=6&db=m Absence of exaggerated pharmacology by recombinant ADAMTS13 in the rat and monkey. causal interaction,unassigned 1,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34327693&form=6&db=m COVID-19 as a Potential Trigger for Immune Thrombotic Thrombocytopenic Purpura and Reason for an Unusual Treatment: A Case Report. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34334786&form=6&db=m Acquired Thrombotic Thrombocytopenic Purpura Without Anti-ADAMTS13 Antibody Caused by Influenza A (H1N1) Virus Successfully Treated by Plasma Exchange: A Case Report. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393175&form=6&db=m Cost-effectiveness of thrombotic thrombocytopenic purpura diagnosis: a retrospective analysis in the University Hospital Center of Lyon (France). diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34495312&form=6&db=m Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura. unassigned - 3.4.24.77 Purpura, Thrombotic Thrombocytopenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527101&form=6&db=m Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient. causal interaction,unassigned 3,0 3.4.24.77 Radicular Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28527839&form=6&db=m Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 3.4.24.77 receptor protein-tyrosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29691281&form=6&db=m Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint. causal interaction,unassigned 1,0 3.4.24.77 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25549795&form=6&db=m The matrix metalloproteinase-7 and pro-enzyme of metalloproteinase-1 as a potential marker for patients with rectal cancer without distant metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11388798&form=6&db=m Systematic separation and purification of elastase, gelatinase (matrix metalloproteinase 9), and collagenase (matrix metalloproteinase 8) from polymorphonuclear leukocytes in dialyzers previously used by patients with renal failure. therapeutic application,unassigned 1,0 3.4.24.77 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892341&form=6&db=m Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17095863&form=6&db=m Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease. unassigned - 3.4.24.77 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25934767&form=6&db=m Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy. causal interaction,unassigned 4,0 3.4.24.77 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637781&form=6&db=m What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7552105&form=6&db=m Chronic renal disease: do metalloproteinase inhibitors have a demonstrable role in extracellular matrix accumulation? causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19953348&form=6&db=m Serum metalloproteinases MMP-2, MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in patients on hemodialysis. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20947535&form=6&db=m ADAMTS-13 deficiency: can it cause chronic renal failure? causal interaction,unassigned 4,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27374915&form=6&db=m The epidermal growth factor receptor pathway in chronic kidney diseases. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29482391&form=6&db=m Systemic inhibition of BMP1-3 decreases progression of CCl diagnostic usage,ongoing research,unassigned 1,2,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30102333&form=6&db=m Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients. diagnostic usage,unassigned 1,0 3.4.24.77 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30509751&form=6&db=m Association between renal dysfunction and metalloproteinase (MMP)-9 activity in hypertensive patients. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.24.77 Reoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21569301&form=6&db=m A functional role for ADAM10 in human immunodeficiency virus type-1 replication. unassigned - 3.4.24.77 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296343&form=6&db=m Phosphoramidon, an endothelin converting enzyme inhibitor attenuates local gastric ischemia-reperfusion injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18322435&form=6&db=m Lung transplant ischemia reperfusion injury: metalloprotease inhibition down-regulates exposure of type V collagen, growth-related oncogene-induced neutrophil chemotaxis, and tumor necrosis factor-alpha expression. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19915515&form=6&db=m Effects of metalloproteinase inhibition in a murine model of renal ischemia-reperfusion injury. ongoing research,therapeutic application,unassigned 4,2,0 3.4.24.77 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23157925&form=6&db=m Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23312814&form=6&db=m Dual role of matrix metalloprotease 9 in liver ischemia and reperfusion injury. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000235&form=6&db=m Neutral endopeptidase in serum samples from patients with adult respiratory distress syndrome. Comparison with angiotensin-converting enzyme. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11469893&form=6&db=m Metalloproteinase inhibition prevents acute respiratory distress syndrome. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15148453&form=6&db=m Effect of polymyxin B-immobilized fiber on blood metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in acute respiratory distress syndrome patients. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29670537&form=6&db=m Impact of Different Tidal Volume Levels at Low Mechanical Power on Ventilator-Induced Lung Injury in Rats. ongoing research,unassigned 4,0 3.4.24.77 Respiratory Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697605&form=6&db=m ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.77 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23791966&form=6&db=m Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11773040&form=6&db=m Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187492&form=6&db=m Efficacy of Prinomastat) (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization. therapeutic application,unassigned 4,0 3.4.24.77 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18844026&form=6&db=m [Advancement of targeting therapy for retinal neovascularization] diagnostic usage,therapeutic application,unassigned 1,2,0 3.4.24.77 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23299479&form=6&db=m Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice. therapeutic application,unassigned 2,0 3.4.24.77 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28264989&form=6&db=m Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays. therapeutic application,unassigned 4,0 3.4.24.77 Retinal Vein Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23791966&form=6&db=m Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12847566&form=6&db=m Gene therapy for the treatment of peripheral vascular disease and coronary artery disease. ongoing research,unassigned 2,0 3.4.24.77 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15938806&form=6&db=m [Analysis of angiogenesis associated factors of retinoblastoma cell line and tumor tissues] causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.4.24.77 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23001705&form=6&db=m Biomarkers of parathyroid carcinoma. ongoing research,unassigned 1,0 3.4.24.77 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29243776&form=6&db=m Hypoxia promotes invasion of retinoblastoma cells in vitro by upregulating HIF-1?/MMP9 signaling pathway. ongoing research,unassigned 2,0 3.4.24.77 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9663476&form=6&db=m Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.77 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10605168&form=6&db=m [Metalloproteinase inhibition: therapeutic application in rheumatic diseases] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683793&form=6&db=m Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases. causal interaction,unassigned 1,0 3.4.24.77 Rheumatic Heart Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25971370&form=6&db=m TGF-?1 and TIMP-4 regulate atrial fibrosis in atrial fibrillation secondary to rheumatic heart disease. ongoing research,unassigned 1,0 3.4.24.77 Rheumatic Heart Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29458338&form=6&db=m Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population. causal interaction,unassigned 1,0 3.4.24.77 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18778489&form=6&db=m Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19786210&form=6&db=m Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.77 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21679521&form=6&db=m Increased expression of a disintegrin and metalloprotease 8 in allergic rhinitis. causal interaction,unassigned 3,0 3.4.24.77 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24908071&form=6&db=m ADAM33 polymorphisms and susceptibility to allergic rhinitis: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.77 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619918&form=6&db=m Association between ADAM33 S2 and V4 polymorphisms and susceptibility to allergic rhinitis: A meta-analysis. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Rickets http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23813354&form=6&db=m PHEX gene mutation in a Chinese family with six cases of X-linked hypophosphatemic rickets. causal interaction,unassigned 3,0 3.4.24.77 Rickets, Hypophosphatemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12791601&form=6&db=m FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. ongoing research,unassigned 1,0 3.4.24.77 Rickets, Hypophosphatemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20924400&form=6&db=m Hereditary disorders of renal phosphate wasting. causal interaction,unassigned 3,0 3.4.24.77 Rosacea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10509643&form=6&db=m Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.4.24.77 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30049795&form=6&db=m Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-?B. ongoing research,unassigned 2,0 3.4.24.77 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2187705&form=6&db=m Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2668335&form=6&db=m Pulmonary alveolar macrophages from patients with active sarcoidosis express type IV collagenolytic proteinase. An enzymatic mechanism for influx of mononuclear phagocytes at sites of disease activity. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3014965&form=6&db=m Thermolysin-like serum metalloendopeptidase. A new marker for active sarcoidosis that complements serum angiotensin-converting enzyme. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.77 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026182&form=6&db=m Clinical significance of serum thermolysin-like metalloendopeptidase and its relationship to serum angiotensin converting enzyme in sarcoidosis. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6366093&form=6&db=m Identification of a thermolysin-like metalloendopeptidase in serum: activity in normal subjects and in patients with sarcoidosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979817&form=6&db=m [Change of matrix metalloproteinase-1 and matrix metalloproteinase-7 in serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and sarcoidosis]. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21959615&form=6&db=m The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhibitor TIMP2 in sarcoidosis. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 Sarcoidosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22040125&form=6&db=m A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Sarcoidosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23857158&form=6&db=m Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2384170&form=6&db=m A novel TIMP-insensitive type IV collagen-degrading metalloproteinase from murine metastatic sarcoma cells. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7472745&form=6&db=m Osteosarcoma oncogene expression detected by in situ hybridization. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7532474&form=6&db=m Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8841807&form=6&db=m Local activity of matrix metalloproteinases in a case of botryoid sarcoma. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11249053&form=6&db=m Metalloproteinase expression and prognosis in soft tissue sarcomas. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12973672&form=6&db=m Tissue and serum loss of metalloproteinase inhibitors in high grade soft tissue sarcomas. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16386243&form=6&db=m Matrix metalloproteinase 2 secretion in WEHI 164 fibrosarcoma cells is nitric oxide-related and modified by morphine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655735&form=6&db=m Novel role of microRNA-126 in digestive system cancers: From bench to bedside. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33605482&form=6&db=m The effect of microRNA-330 replacement on inhibition of growth and migration in renal cancer cells. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.77 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848240&form=6&db=m Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts. causal interaction,unassigned 3,0 3.4.24.77 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026634&form=6&db=m Fibronectin-degrading proteases from the membranes of transformed cells. unassigned - 3.4.24.77 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535415&form=6&db=m Augmentation of metalloproteinase (gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src. ongoing research,unassigned 4,0 3.4.24.77 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846984&form=6&db=m Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase. unassigned - 3.4.24.77 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10511596&form=6&db=m Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130577&form=6&db=m Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16630504&form=6&db=m [Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Sarcopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30187662&form=6&db=m Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis - results from the CHIKARA study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15324465&form=6&db=m Dynamics of collagen, MMP and TIMP gene expression during the granulomatous, fibrotic process induced by Schistosoma mansoni eggs. causal interaction,unassigned 3,0 3.4.24.77 Scleredema Adultorum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7662581&form=6&db=m Scleredema adultorum: case report and demonstration of abnormal expression of extracellular matrix genes in skin fibroblasts in vivo and in vitro. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Scleritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22823240&form=6&db=m Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392585&form=6&db=m Serum levels of tissue inhibitors of metalloproteinase 2 in patients with systemic sclerosis with duration more than 2 years: correlation with cardiac and pulmonary abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794969&form=6&db=m Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110530&form=6&db=m Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European caucasian population. unassigned - 3.4.24.77 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34512395&form=6&db=m Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention. therapeutic application,unassigned 1,0 3.4.24.77 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17426029&form=6&db=m Beta-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity. causal interaction,unassigned 3,0 3.4.24.77 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763262&form=6&db=m In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold? unassigned - 3.4.24.77 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24946277&form=6&db=m Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.77 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27886560&form=6&db=m Serum metalloproteinase 9 levels increase after generalized tonic-clonic seizures. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.77 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080184&form=6&db=m Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2478526&form=6&db=m Inhibitory effect of alpha 2-macroglobulin on Vibrio vulnificus protease. causal interaction,unassigned 2,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7594783&form=6&db=m [Detection of Bacteroides fragilis enterotoxin from extraintestinal clinical isolates of B. fragilis group organisms] causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7682528&form=6&db=m Chemical modification of Vibrio vulnificus metalloprotease with activated polyethylene glycol. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8789055&form=6&db=m Actions of Vibrio vulnificus metalloprotease on human plasma proteinase-proteinase inhibitor systems: a comparative study of native protease with its derivative modified by polyethylene glycol. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393733&form=6&db=m Functional domains of a zinc metalloprotease from Vibrio vulnificus. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10816513&form=6&db=m Metalloprotease is not essential for Vibrio vulnificus virulence in mice. causal interaction,unassigned 4,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628443&form=6&db=m Histamine-releasing reaction induced by the N-terminal domain of Vibrio vulnificus metalloprotease. ongoing research,unassigned 4,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726228&form=6&db=m High growing ability of Vibrio vulnificus biotype 1 is essential for production of a toxic metalloprotease causing systemic diseases in humans. causal interaction,unassigned 3,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644589&form=6&db=m The N-terminal propeptide of Vibrio vulnificus extracellular metalloprotease is both an inhibitor of and a substrate for the enzyme. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17885389&form=6&db=m ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin) and endothelial dysfunction in sepsis: marker or culprit? ongoing research,unassigned 1,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20356362&form=6&db=m Matrix- metalloproteinase -2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20832124&form=6&db=m Serum haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complex as a biomarker of systemic inflammation in cattle. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24238574&form=6&db=m The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25860876&form=6&db=m Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27379832&form=6&db=m Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28144586&form=6&db=m Interaction of Bacteroides fragilis Toxin with Outer Membrane Vesicles Reveals New Mechanism of Its Secretion and Delivery. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28410274&form=6&db=m Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. therapeutic application,unassigned 1,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29979219&form=6&db=m Molecular Regulation of Acute Tie2 Suppression in Sepsis. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30524657&form=6&db=m Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis. therapeutic application,unassigned 1,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31086585&form=6&db=m Risk stratification and prognostic evaluation of endothelial cell-specific molecule1, von Willebrand factor, and a disintegrin-like and metalloprotease with thrombospondin type 1 motif for sepsis in the emergency department: An observational study. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435099&form=6&db=m Plasmapheresis in Sepsis-induced Thrombotic Microangiopathy: A Case Series. unassigned - 3.4.24.77 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32838837&form=6&db=m Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.77 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33957057&form=6&db=m The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19. ongoing research,unassigned 2,0 3.4.24.77 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9610608&form=6&db=m Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Sexually Transmitted Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25956139&form=6&db=m Lower concentrations of chemotactic cytokines and soluble innate factors in the lower female genital tract associated with the use of injectable hormonal contraceptive. diagnostic usage,unassigned 2,0 3.4.24.77 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9856688&form=6&db=m Modulation of plasma metalloproteinase-9 concentrations and peripheral blood monocyte mRNA levels in patients with septic shock: effect of fiber-immobilized polymyxin B treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.4.24.77 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17017880&form=6&db=m Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.77 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24238574&form=6&db=m The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27414801&form=6&db=m Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Shoulder Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17299449&form=6&db=m Functional staging and surgical intervention of the elbow and shoulder joints in a patient with rheumatoid arthritis. diagnostic usage,unassigned 3,0 3.4.24.77 Sjogren's Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16341369&form=6&db=m [Viral Tax protein expression in salivary glands of patients infected with human t-cell lymphotropic virus type I and Sicca Syndrome.] diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22040125&form=6&db=m A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042068&form=6&db=m Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.24.77 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837354&form=6&db=m Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells. ongoing research,unassigned 4,0 3.4.24.77 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9213309&form=6&db=m Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer. therapeutic application,unassigned 4,0 3.4.24.77 Smoldering Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197802&form=6&db=m DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.77 snapalysin deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116735&form=6&db=m Erratum to "Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes". causal interaction,unassigned 4,0 3.4.24.77 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31410686&form=6&db=m Epitope Mapping of Tetanus Toxin by Monoclonal Antibodies: Implication for Immunotherapy and Vaccine Design. ongoing research,therapeutic application,unassigned 1,2,0 3.4.24.77 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22798270&form=6&db=m Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.77 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27425890&form=6&db=m Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.77 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28363523&form=6&db=m Cordycepin-enriched WIB-801C from Cordyceps militaris improves functional recovery by attenuating blood-spinal cord barrier disruption after spinal cord injury. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Spinal Dysraphism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31486131&form=6&db=m Urinary TIMP-2 and MMP-2 are significantly associated with poor bladder compliance in adult patients with spina bifida. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21688534&form=6&db=m [Effects of Bushen qiangdu decoction on MMP-9 and TIMP-1 produced by peripheral blood mononuclear cells in patients with ankylosing spondylitis]. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Spondylosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29072013&form=6&db=m [Effects of Chiropractics on Intervertebral Disk Extracell Matrix and Metabolic Enzymes in Rats with Cervical Spondylosis]. ongoing research,unassigned 3,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815580&form=6&db=m Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11640889&form=6&db=m Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169394&form=6&db=m Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma. ongoing research,unassigned 2,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414665&form=6&db=m Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12897567&form=6&db=m Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15831673&form=6&db=m Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16142392&form=6&db=m Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309826&form=6&db=m Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204469&form=6&db=m MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. ongoing research,unassigned 4,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999917&form=6&db=m Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015455&form=6&db=m Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20305301&form=6&db=m Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20505783&form=6&db=m Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22769410&form=6&db=m The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma. ongoing research,unassigned 4,0 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24403253&form=6&db=m ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.4.24.77 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25956455&form=6&db=m Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.77 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6099946&form=6&db=m Proteinase pattern in Trametes versicolor in response to carbon and nitrogen starvation. unassigned - 3.4.24.77 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18595316&form=6&db=m Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans. therapeutic application,unassigned 1,0 3.4.24.77 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24837289&form=6&db=m Nutrient-regulated proteolysis of MrpC halts expression of genes important for commitment to sporulation during Myxococcus xanthus development. unassigned - 3.4.24.77 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26253597&form=6&db=m Epileptogenesis after traumatic brain injury in Plau-deficient mice. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28292736&form=6&db=m Increased metalloproteinase activity in the hippocampus following status epilepticus. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1346086&form=6&db=m [New prognostic factors in human gastric carcinomas] causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626810&form=6&db=m Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681807&form=6&db=m Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11351259&form=6&db=m Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20333791&form=6&db=m Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21105003&form=6&db=m ADAM 10 is associated with gastric cancer progression and prognosis of patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21259244&form=6&db=m ADAM 10 is associated with gastric cancer progression and prognosis of patients. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460086&form=6&db=m VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue. unassigned - 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231630&form=6&db=m Thrombin conducts epithelial?mesenchymal transition via protease?activated receptor?1 in human gastric cancer. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26024798&form=6&db=m Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31347325&form=6&db=m A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32610677&form=6&db=m Prognostic Significance of ADAM17 for Gastric Cancer Survival: A Meta-Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851708&form=6&db=m Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33864820&form=6&db=m Melatonin indirectly decreases gastric cancer cell proliferation and invasion via effects on cancer-associated fibroblasts. therapeutic application,unassigned 1,0 3.4.24.77 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514104&form=6&db=m Helicobacter pylori promotes gastric cancer progression by upregulating semaphorin 5A expression via ERK/MMP9 signaling. ongoing research,unassigned 2,0 3.4.24.77 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23901237&form=6&db=m Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108768&form=6&db=m Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11700147&form=6&db=m Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15727269&form=6&db=m Extracellular proteolytic pathophysiology in the neurovascular unit after stroke. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15832061&form=6&db=m Cerebral ischemic events in patients with advanced lung or prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947272&form=6&db=m A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16717217&form=6&db=m Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18834996&form=6&db=m Sonographic monitoring of mass effect in stroke patients treated with hypothermia. Correlation with intracranial pressure and matrix metalloproteinase 2 and 9 expression. ongoing research,unassigned 1,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20923324&form=6&db=m Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study. ongoing research,unassigned 2,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20955435&form=6&db=m Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment? therapeutic application,unassigned 3,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22374533&form=6&db=m [Exacerbation of cranial nerurological symptoms by platelet transfusion before the diagnosis of thrombotic thrombocytopenic purpura]. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23225307&form=6&db=m Role of reduced ADAMTS13 in arterial ischemic stroke: a pediatric cohort study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23280993&form=6&db=m Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702312&form=6&db=m Role of HIF-1?-activated Epac1 on HSC-mediated neuroplasticity in stroke model. unassigned - 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23827079&form=6&db=m [Advances in the biochemical markers of complications associated with carotid endarterectomy]. unassigned - 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24963695&form=6&db=m The effect of recombinant tissue plasminogen activator on MMP-2 and MMP-9 activities in vitro. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26839355&form=6&db=m Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412500&form=6&db=m Rare Variants in the ADAMTS13 Von Willebrand Factor-Binding Domain Contribute to Pediatric Stroke. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28266892&form=6&db=m Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis. therapeutic application,unassigned 1,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453088&form=6&db=m Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185010&form=6&db=m ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31721277&form=6&db=m Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study. ongoing research,therapeutic application,unassigned 2,3,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32009522&form=6&db=m Angiogenesis-Related Genes in Endothelial Progenitor Cells May Be Involved in Sickle Cell Stroke. ongoing research,unassigned 2,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32248810&form=6&db=m Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32817637&form=6&db=m ADAMTS12, a new candidate gene for pediatric stroke. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Strongyloidiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2137091&form=6&db=m Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae. causal interaction,unassigned 3,0 3.4.24.77 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25785135&form=6&db=m The changes of von willebrand factor/a disintegrin-like and metalloprotease with thrombospondin type I repeats-13 balance in aneurysmal subarachnoid hemorrhage. ongoing research,therapeutic application,unassigned 1,4,0 3.4.24.77 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062605&form=6&db=m Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.24.77 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17878211&form=6&db=m Serum levels of sex steroid hormones and matrix metalloproteinases after intra-articular glucocorticoid treatment in female patients with rheumatoid arthritis. therapeutic application,unassigned 3,0 3.4.24.77 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23578941&form=6&db=m The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.77 Syphilis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31319358&form=6&db=m Treponema pallidum enhances human monocyte migration and invasion by dysregulating the MMP/TIMP balance. causal interaction,unassigned 3,0 3.4.24.77 Tachycardia, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17526509&form=6&db=m Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction. unassigned - 3.4.24.77 Telangiectasia, Hereditary Hemorrhagic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723034&form=6&db=m Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723034&form=6&db=m Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Temporomandibular Joint Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10922168&form=6&db=m Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disorders. diagnostic usage,ongoing research,unassigned 2,1,0 3.4.24.77 Temporomandibular Joint Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29963493&form=6&db=m Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27624782&form=6&db=m Photobiomodulation therapy on collagen type I and III, vascular endothelial growth factor, and metalloproteinase in experimentally induced tendinopathy in aged rats. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.24.77 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553748&form=6&db=m Mini-Review: Toxic Tendinopathy. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31778275&form=6&db=m Tissue inhibitor of metalloproteinase proteins inhibit teratoma growth in mice transplanted with pluripotent stem cells. ongoing research,unassigned 4,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7929108&form=6&db=m The role of transglutaminase in the mechanism of action of tetanus toxin. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7991646&form=6&db=m Tetanus toxin as a neurobiological tool to study mechanisms of neuronal cell death in the mammalian brain. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253064&form=6&db=m Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8305898&form=6&db=m Analysis of the structure and expression of the VAMP family of synaptic vesicle proteins. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8360142&form=6&db=m Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8542757&form=6&db=m Intracellular targets and metalloprotease activity of tetanus and botulism neurotoxins. ongoing research,unassigned 1,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8921173&form=6&db=m A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity. diagnostic usage,unassigned 2,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762166&form=6&db=m Cell swelling-induced signaling for insulin secretion bypasses steps involving G proteins and PLA2 and is N-ethylmaleimide insensitive. ongoing research,unassigned 1,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18554757&form=6&db=m Residual enzymatic activity of the tetanus toxin light chain present in tetanus toxoid batches used for vaccine production. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519507&form=6&db=m Bacterial toxins: an overview on bacterial proteases and their action as virulence factors. unassigned - 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20527521&form=6&db=m Human monoclonal ScFv that inhibits cellular entry and metalloprotease activity of tetanus neurotoxin. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577757&form=6&db=m Tetanus neurotoxin-induced epilepsy in mouse visual cortex. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31771110&form=6&db=m Tables of Toxicity of Botulinum and Tetanus Neurotoxins. causal interaction,unassigned 2,0 3.4.24.77 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33629408&form=6&db=m TETANUS and TETANUS NEUROTOXIN: from peripheral uptake to central nervous tissue targets. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Theileriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15275152&form=6&db=m A role for matrix metalloproteinases in the pathology and attenuation of Theileria annulata infections. causal interaction,unassigned 1,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15019481&form=6&db=m Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113795&form=6&db=m Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. unassigned - 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18574040&form=6&db=m Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18988930&form=6&db=m Linear relationship between ADAMTS13 activity and platelet dynamics even before severe thrombocytopenia. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022799&form=6&db=m Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530051&form=6&db=m A Difficult Diagnosis Case of Prolonged Thrombocytopenia With Sepsis and Disseminated Intravascular Coagulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590698&form=6&db=m A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient. unassigned - 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21657946&form=6&db=m Investigational drugs in thrombotic thrombocytopenic purpura. causal interaction,unassigned 1,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22265954&form=6&db=m Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595551&form=6&db=m Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of history of splenectomy: the significance of ADAMTS13 and graft function. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26081109&form=6&db=m Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637781&form=6&db=m What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28410274&form=6&db=m Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. therapeutic application,unassigned 1,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28978852&form=6&db=m New developments in treatment modalities of thrombotic thrombocytopenic purpura. causal interaction,unassigned 3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130141&form=6&db=m Sjögren's syndrome initially presented as thrombotic thrombocytopenic purpura in a male patient: a case report and literature review. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30222856&form=6&db=m Secondary thrombotic microangiopathy with severely reduced ADAMTS13 activity in a patient with Capnocytophaga canimorsus sepsis: a case report. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30235478&form=6&db=m Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab. causal interaction,unassigned 3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30412131&form=6&db=m Relapsed/refractory acquired thrombotic thrombocytopenic purpura in a patient with Sjögren syndrome: Case report and review of the literature. causal interaction,unassigned 3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31250841&form=6&db=m Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura. causal interaction,unassigned 4,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31283011&form=6&db=m Emerging roles of adjunct therapies in acquired thrombotic thrombocytopenia purpura. causal interaction,unassigned 3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31585956&form=6&db=m Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events. unassigned - 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061729&form=6&db=m Assessment and Monitoring of Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): Strategies to Improve Outcomes. causal interaction,unassigned 3,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33842174&form=6&db=m Silent Thrombotic Thrombocytopenic Purpura: PLASMIC, Lessons Learned, and Current Management Overview. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.4.24.77 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527101&form=6&db=m Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient. causal interaction,unassigned 3,0 3.4.24.77 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31139312&form=6&db=m ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11368309&form=6&db=m Chimeric derivative of fibrolase, a fibrinolytic enzyme from southern copperhead venom, possesses inhibitory activity on platelet aggregation. therapeutic application,unassigned 3,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414517&form=6&db=m Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679078&form=6&db=m Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis. therapeutic application,unassigned 1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15208802&form=6&db=m [Should we begin with statin therapy in acute coronary syndrome?] causal interaction,unassigned 4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15249683&form=6&db=m Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16201838&form=6&db=m Current concepts in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16388417&form=6&db=m Molecular biology of ADAMTS13 and diagnostic utility of ADAMTS13 proteolytic activity and inhibitor assays. causal interaction,unassigned 4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409158&form=6&db=m Current concepts in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146059&form=6&db=m Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17427056&form=6&db=m Emerging technologies in hemostasis diagnostics: a report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group. therapeutic application,unassigned 2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632486&form=6&db=m Clinical utility of novel agents in the treatment of central venous catheter occlusion. therapeutic application,unassigned 4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20177108&form=6&db=m MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic aneurysms in humans. diagnostic usage,ongoing research,unassigned 4,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20432945&form=6&db=m [Stable expression and characterization of the von Willebrand factor cleaving protease] ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20923324&form=6&db=m Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study. ongoing research,unassigned 2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21146487&form=6&db=m Escherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity. diagnostic usage,unassigned 3,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21494805&form=6&db=m In vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall. ongoing research,unassigned 1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21557445&form=6&db=m Serine and metalloprotease signaling through PAR1 in arterial thrombosis and vascular injury. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843064&form=6&db=m SNPs in ADAMTS13. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022775&form=6&db=m Thrombotic Thrombocytopenic Purpura and Anti-Thrombotic Therapy Targeted to Von Willebrand Factor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22123843&form=6&db=m ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22652598&form=6&db=m Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22782575&form=6&db=m ADAMTS13 exerts a thrombolytic effect in microcirculation. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23763262&form=6&db=m In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold? unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24357063&form=6&db=m Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24679129&form=6&db=m Effect of recombinant ADAMTS13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25386342&form=6&db=m ADAMTS-13 in the Diagnosis and Management of Thrombotic Microangiopathies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25512528&form=6&db=m Allosteric activation of ADAMTS13 by von Willebrand factor. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916953&form=6&db=m Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26121272&form=6&db=m High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIV-infected patients. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556655&form=6&db=m Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis. ongoing research,unassigned 2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27005894&form=6&db=m Balance between von Willebrand factor and ADAMTS13 following major partial hepatectomy. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28320710&form=6&db=m Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice. causal interaction,unassigned 4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28495930&form=6&db=m ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28552727&form=6&db=m Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28651806&form=6&db=m Von Willebrand Factor Deposition and ADAMTS-13 Consumption in Allograft Tissue of Thrombotic Microangiopathy-like Disorder After Living Donor Liver Transplantation: A Case Report. causal interaction,unassigned 2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29367415&form=6&db=m Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice. causal interaction,unassigned 1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30046741&form=6&db=m MMP-13 binds to platelet receptors ?IIb?3 and GPVI and impairs aggregation and thrombus formation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30158745&form=6&db=m Plasma von Willebrand Factor and a Disintegrin and Metalloproteinase with Eight Thrombospondin-type 1 Motif Levels in Hemodialysis Patients: Relation to Vascular Access Thrombosis. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30222754&form=6&db=m Destabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulations. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354235&form=6&db=m Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30586332&form=6&db=m Correction to: Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30679946&form=6&db=m AFM Imaging Reveals Multiple Conformational States of ADAMTS13. causal interaction,unassigned 3,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700419&form=6&db=m Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31340669&form=6&db=m Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura. ongoing research,therapeutic application,unassigned 2,4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31379722&form=6&db=m ADAMTS13: An Emerging Target in Stroke Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31438579&form=6&db=m Isolation of a Novel Metalloproteinase from Agkistrodon Venom and Its Antithrombotic Activity Analysis. causal interaction,unassigned 2,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075652&form=6&db=m ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32205561&form=6&db=m Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32588586&form=6&db=m Reference range for ADAMTS13 antigen, activity and anti-ADAMTS13 antibody in the healthy adult Singapore population. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32829217&form=6&db=m Von Willebrand Factor and ADAMTS13 and long-term outcomes in patients undergoing percutaneous coronary intervention. causal interaction,unassigned 4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32838472&form=6&db=m Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292287&form=6&db=m Von Willebrand factor:antigen and ADAMTS-13 level, but not soluble P-selectin, are risk factors for the first asymptomatic deep vein thrombosis in cancer patients undergoing chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33979555&form=6&db=m Actin polymerization regulates glycoprotein Ib? shedding. unassigned - 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34380671&form=6&db=m Congenital ADAMTS-13 deficiency presenting as life-threatening thrombosis during pregnancy. causal interaction,unassigned 4,0 3.4.24.77 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517169&form=6&db=m Characterization of the interactions of ADAMTS13 CUB1 domain to WT- and GOF-Spacer domain by molecular dynamics simulation. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12038781&form=6&db=m Complete defect in vWF-cleaving protease activity associated with increased shear-induced platelet aggregation in thrombotic microangiopathy. diagnostic usage,unassigned 1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421153&form=6&db=m Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. diagnostic usage,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901144&form=6&db=m Pathogenesis of thrombotic thrombocytopenic purpura. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16129029&form=6&db=m [Expression of the metalloproteinase domain of von Willebrand factor-cleaving protease and preparation of its McAb] unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17900666&form=6&db=m ADAMTS13 related markers and von Willebrand factor in plasma from patients with thrombotic microangiopathy (TMA). diagnostic usage,ongoing research,unassigned 4,2,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18766104&form=6&db=m Intensive plasma exchange increases ADAMTS-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18828196&form=6&db=m Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19959109&form=6&db=m Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20443921&form=6&db=m Thrombotic microangiopathies: multimers, metalloprotease, and beyond. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20947535&form=6&db=m ADAMTS-13 deficiency: can it cause chronic renal failure? causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21238935&form=6&db=m Structure and Proteolytic Properties of ADAMTS13, A Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21531732&form=6&db=m ADAMTS13--more than just TMA and TTP. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21657946&form=6&db=m Investigational drugs in thrombotic thrombocytopenic purpura. causal interaction,unassigned 1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22193233&form=6&db=m Attending rounds: microangiopathic hemolytic anemia with renal insufficiency. causal interaction,therapeutic application,unassigned 1,4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22265954&form=6&db=m Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22374540&form=6&db=m Donor Age Affects Liver Regeneration during Early Period in the Graft Liver and Late Period in the Remnant Liver after Living Donor Liver Transplantation. diagnostic usage,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22473663&form=6&db=m Autoimmune thrombotic microangiopathy: advances in pathogenesis, diagnosis, and management. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22529289&form=6&db=m A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22879435&form=6&db=m Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24033710&form=6&db=m Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25377323&form=6&db=m Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25860876&form=6&db=m Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26272487&form=6&db=m The D173G mutation in ADAMTS-13 causes a severe form of congenital thrombotic thrombocytopenic purpura. A clinical, biochemical andin silico study. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26359646&form=6&db=m The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry. diagnostic usage,unassigned 1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911616&form=6&db=m Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27132698&form=6&db=m Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27435311&form=6&db=m Influenza-associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S-deficient boy. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27479501&form=6&db=m Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720178&form=6&db=m Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28248832&form=6&db=m Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28380082&form=6&db=m Heparin-induced thrombocytopenia as a cause of prolonged low platelet count in a patient with thrombotic thrombocytopenic purpura treated with plasmapheresis. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28635017&form=6&db=m Clinical features and outcomes in patients with thrombotic microangiopathy not associated with severe ADAMTS13 deficiency. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28679995&form=6&db=m Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759473&form=6&db=m Novel therapeutic approaches for thrombotic thrombocytopenic purpura. ongoing research,unassigned 1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28980147&form=6&db=m ADAMTS13 missense variants associated with defective activity and secretion of ADAMTS13 in a patient with non-cirrhotic portal hypertension. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942494&form=6&db=m Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency. diagnostic usage,unassigned 1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29963519&form=6&db=m Clinical characteristics and outcomes of thrombotic microangiopathy in Malaysia. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30410841&form=6&db=m A Case of Recurrent Thrombotic Microangiopathy Caused by Hypertensive Urgency. ongoing research,unassigned 2,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447150&form=6&db=m Chest pain with increased troponin level; not always a cardiology issue. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30919938&form=6&db=m Comparison of Rituximab originator (MabThera) to biosimilar (Truxima) in patients with immune-mediated thrombotic thrombocytopenic purpura. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930238&form=6&db=m Inherited Thrombotic Thrombocytopenic Purpura Revealed by Recurrent Strokes in a Male Adult: Case Report and Literature Review. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31587247&form=6&db=m Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32507820&form=6&db=m [Diagnosis and treatment of thrombotic thrombocytopenic purpura]. causal interaction,unassigned 3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32598743&form=6&db=m [Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions]. causal interaction,unassigned 3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061729&form=6&db=m Assessment and Monitoring of Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): Strategies to Improve Outcomes. causal interaction,unassigned 3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33096882&form=6&db=m The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians. causal interaction,unassigned 1,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33512705&form=6&db=m Performance of Diagnostic Scores in Thrombotic Microangiopathy Patients in the Intensive Care Unit: A Monocentric Study. unassigned - 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537532&form=6&db=m Diagnosis and follow-up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33834592&form=6&db=m A human monoclonal antibody against the distal carboxyl terminus of ADAMTS-13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34113115&form=6&db=m Unresponsive Thrombotic Thrombocytopenic Purpura (TTP): Challenges and Solutions. causal interaction,unassigned 4,0 3.4.24.77 Thrombotic Microangiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34334786&form=6&db=m Acquired Thrombotic Thrombocytopenic Purpura Without Anti-ADAMTS13 Antibody Caused by Influenza A (H1N1) Virus Successfully Treated by Plasma Exchange: A Case Report. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12643848&form=6&db=m Clinical significance of tissue inhibitor of metalloproteinase and matrix metalloproteinase mRNA expression in thymoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.77 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19162222&form=6&db=m Lipodystrophies: Disorders of adipose tissue biology. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19494770&form=6&db=m Inherited lipodystrophies and hypertriglyceridemia. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21154860&form=6&db=m p28(GANK) overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1? pathways. causal interaction,unassigned 3,0 3.4.24.77 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21254169&form=6&db=m p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1? pathways. causal interaction,unassigned 3,0 3.4.24.77 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17091452&form=6&db=m [Gene expression of metalloproteinase 11, claudin 1 and selected adhesion related genes in papillary thyroid cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.24.77 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20306451&form=6&db=m Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis. ongoing research,unassigned 2,0 3.4.24.77 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9279566&form=6&db=m Matrix metalloproteinases and tissue inhibitors of metalloproteinases in thyroid C-cells and medullary thyroid carcinomas. ongoing research,unassigned 2,0 3.4.24.77 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18651826&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: prognostic implications. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.4.24.77 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19530676&form=6&db=m Cell surface and secreted protein profiles of human thyroid cancer cell lines reveal distinct glycoprotein patterns. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.77 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687404&form=6&db=m Ratio of metalloproteinase 2 to tissue inhibitor of metalloproteinase 2 in medullary thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 3.4.24.77 Tinea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2691741&form=6&db=m [The relation between the growth and extracellular proteolytic activity in trichophyton rubrum, comparing isolates from granuloma trichophyticum with tinea superficialis] ongoing research,unassigned 2,0 3.4.24.77 Tinea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14725323&form=6&db=m Humoral and cellular immune response to a Microsporum canis recombinant keratinolytic metalloprotease (r-MEP3) in experimentally infected guinea pigs. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.77 Tinea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14985633&form=6&db=m Isolation of a promoter region of a secreted metalloprotease gene from Microsporum canis. unassigned - 3.4.24.77 Tooth Mobility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30517321&form=6&db=m Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.24.77 Toxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26615468&form=6&db=m Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors. causal interaction,unassigned 2,0 3.4.24.77 Trachoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15557667&form=6&db=m Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic. therapeutic application,unassigned 1,0 3.4.24.77 Trichiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29653629&form=6&db=m Oral doxycycline for the prevention of postoperative trachomatous trichiasis in Ethiopia: a randomised, double-blind, placebo-controlled trial. ongoing research,therapeutic application,unassigned 1,2,0 3.4.24.77 Trichomonas Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23579185&form=6&db=m TvMP50 is an immunogenic metalloproteinase during male trichomoniasis. causal interaction,unassigned 4,0 3.4.24.77 Trichomonas Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28887063&form=6&db=m The 50kDa metalloproteinase TvMP50 is a zinc-mediated Trichomonas vaginalis virulence factor. causal interaction,unassigned 2,0 3.4.24.77 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25336660&form=6&db=m N-glycosylation regulates ADAM8 processing and activation. ongoing research,unassigned 4,0 3.4.24.77 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25933064&form=6&db=m Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression. ongoing research,unassigned 3,0 3.4.24.77 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27039296&form=6&db=m miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. causal interaction,unassigned 3,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16141443&form=6&db=m Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20545848&form=6&db=m M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates. therapeutic application,unassigned 1,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21216669&form=6&db=m Mycobacterium tuberculosis Rv0198c, a putative matrix metalloprotease is involved in pathogenicity. causal interaction,unassigned 2,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813647&form=6&db=m Crystal structure of Mycobacterium tuberculosis ZMP1, a metalloprotease involved in pathogenicity. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23857158&form=6&db=m Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24767848&form=6&db=m Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. unassigned - 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139900&form=6&db=m Mycobacterium tuberculosis alters the metalloprotease activity of the COP9 signalosome. unassigned - 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25657094&form=6&db=m Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31703818&form=6&db=m Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1. causal interaction,unassigned 3,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32218787&form=6&db=m Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Are Potential Biomarkers of Pulmonary and Extra-Pulmonary Tuberculosis. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33378640&form=6&db=m Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states. unassigned - 3.4.24.77 Tuberculosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27797337&form=6&db=m [The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.77 Tuberculosis, Spinal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28829887&form=6&db=m Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.77 Unconsciousness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12673944&form=6&db=m [Immunohistochemical findings in prolonged cerebral hypoxia] causal interaction,unassigned 4,0 3.4.24.77 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8614290&form=6&db=m Serum type III, IV collagens and TIMP in patients with type II diabetes mellitus. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.77 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489731&form=6&db=m Partial ureteral obstruction dysregulates the renal renin-angiotensin system in the fetal sheep kidney. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.77 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583485&form=6&db=m Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction. ongoing research,unassigned 4,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2845110&form=6&db=m Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts. ongoing research,unassigned 3,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293654&form=6&db=m Significance of collagenase 3 (matrix metalloproteinase 13) in invasive bladder cancer: correlation with pathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758628&form=6&db=m A novel approach to using matrix metalloproteinases for bladder cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21351095&form=6&db=m The importance of integrin-linked kinase in the regulation of bladder cancer invasion. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22966365&form=6&db=m Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622883&form=6&db=m Evaluation of MMP-2, MMP-9, TIMP-1, TIMP-2, NGAL and MMP-9/NGAL complex in urine and sera from patients with bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27355528&form=6&db=m Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer. therapeutic application,unassigned 1,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29038419&form=6&db=m Expression and Clinical Significance of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and a Disintegrin and Metalloproteinase with Thrombospondin Type 1 Motif 1 (ADAMTS1) in Post-Kidney-Transplant Bladder Tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32053096&form=6&db=m Role of serum and urine transforming growth factor beta 1, matrix metallopeptidase 9, tissue inhibitor of metalloproteinase 2, and nerve growth factor beta levels and serum neutrophil-to-lymphocyte ratio in predicting recurrence and progression risks in patients with primary non-muscle invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 3.4.24.77 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32547057&form=6&db=m The microRNA miR-3174 Suppresses the Expression of ADAM15 and Inhibits the Proliferation of Patient-Derived Bladder Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.77 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12861139&form=6&db=m Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.77 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15902165&form=6&db=m Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones? causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30388611&form=6&db=m The role of ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of uterosacral and cardinal ligaments in the etiopathogenesis of pelvic organ prolapse among women without stress urinary incontinence. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9159200&form=6&db=m The foundations of successful RT in situ PCR. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10650781&form=6&db=m Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage IB cervical cancer. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196168&form=6&db=m A novel role of metalloproteinase in cancer-mediated immunosuppression. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317213&form=6&db=m Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling. ongoing research,unassigned 2,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24381415&form=6&db=m No Association of Matrix Metalloproteinase [MMP]-2 (-735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (-418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24403492&form=6&db=m Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26006035&form=6&db=m Anti-tumor activity of staurosporine in the tumor microenvironment of cervical cancer: An in vitro study. ongoing research,unassigned 3,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849054&form=6&db=m Human papillomavirus E6-regulated microRNA-20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29177591&form=6&db=m MicroRNA-21 promotes proliferation, migration, and invasion of cervical cancer through targeting TIMP3. therapeutic application,unassigned 1,0 3.4.24.77 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30820752&form=6&db=m Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.77 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059262&form=6&db=m Identification of Autoantigens in Body Fluids by Combining Pull-Downs and Organic Precipitations of Intact Immune Complexes with Quantitative Label-Free Mass Spectrometry. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.77 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194761&form=6&db=m Vaccinia virus G1 protein, a predicted metalloprotease, is essential for morphogenesis of infectious virions but not for cleavage of major core proteins. therapeutic application,unassigned 1,0 3.4.24.77 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16504157&form=6&db=m Mutational analysis of the potential catalytic residues of the VV G1L metalloproteinase. unassigned - 3.4.24.77 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594571&form=6&db=m ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity. unassigned - 3.4.24.77 Varicose Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9204962&form=6&db=m Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.77 Varicose Veins http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19847861&form=6&db=m Pathogenesis of primary varicose veins. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.77 Varicose Veins http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27329669&form=6&db=m Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12847566&form=6&db=m Gene therapy for the treatment of peripheral vascular disease and coronary artery disease. ongoing research,unassigned 2,0 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22205175&form=6&db=m Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22564605&form=6&db=m Effects of cyclosporine on metalloproteinase in endothelial cells. causal interaction,unassigned 3,0 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25716558&form=6&db=m Effects of baicalin on collagen ? and collagen ??? expression in pulmonary arteries of rats with hypoxic pulmonary hypertension. ongoing research,unassigned 4,0 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25926412&form=6&db=m The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates. causal interaction,unassigned 2,0 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26563155&form=6&db=m A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30910225&form=6&db=m Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.77 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32923459&form=6&db=m ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.24.77 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146059&form=6&db=m Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease. unassigned - 3.4.24.77 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21557445&form=6&db=m Serine and metalloprotease signaling through PAR1 in arterial thrombosis and vascular injury. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.77 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26850053&form=6&db=m Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. ongoing research,unassigned 2,0 3.4.24.77 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517169&form=6&db=m Characterization of the interactions of ADAMTS13 CUB1 domain to WT- and GOF-Spacer domain by molecular dynamics simulation. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.77 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32728521&form=6&db=m Hypertensive emergency presenting with diffuse alveolar hemorrhaging and thrombotic microangiopathy: A case report and review of the literature. causal interaction,diagnostic usage,unassigned 1,4,0 3.4.24.77 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664330&form=6&db=m The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2 3.4.24.77 Venous Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11240267&form=6&db=m Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.4.24.77 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556655&form=6&db=m Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis. ongoing research,unassigned 2,0 3.4.24.77 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27876598&form=6&db=m Antithrombotic activity of Batroxase, a metalloprotease from Bothrops atrox venom, in a model of venous thrombosis. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.77 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28320710&form=6&db=m Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice. causal interaction,unassigned 4,0 3.4.24.77 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594571&form=6&db=m ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity. unassigned - 3.4.24.77 Vibrio Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18930131&form=6&db=m Microbial and histopathological study of the vibriosis caused by Vibrio vulnificus serovar E in eels: the metalloprotease Vvp is not an essential lesional factor. diagnostic usage,unassigned 1,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7499970&form=6&db=m Interferon-gamma inhibits HIV-induced invasiveness of monocytes. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11817044&form=6&db=m Separation and identification methods for metalloproteinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18931068&form=6&db=m Corticosteroids modulate Seoul virus infection, regulatory T-cell responses and matrix metalloprotease 9 expression in male, but not female, Norway rats. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22831170&form=6&db=m Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28325251&form=6&db=m Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29475600&form=6&db=m Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30723129&form=6&db=m A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31409686&form=6&db=m Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33864946&form=6&db=m The role of Smad1/5 in mantle immunity of the pearl oyster Pinctada fucata martensii. unassigned - 3.4.24.77 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34523355&form=6&db=m ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.24.77 Vitamin B 12 Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30865166&form=6&db=m Atypical hemolytic uremic syndrome and complement blockade: established and emerging uses of complement inhibition. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.24.77 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23466209&form=6&db=m The metalloproteinase system and vitamin D deficiency. unassigned - 3.4.24.77 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985026&form=6&db=m Role of the p53?TRPM1/miR?211?MMP9 axis in UVB?induced human melanocyte migration and its potential in repigmentation. unassigned - 3.4.24.77 von Hippel-Lindau Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.77 von Willebrand Disease, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14525793&form=6&db=m An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13. unassigned - 3.4.24.77 von Willebrand Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14525793&form=6&db=m An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13. unassigned - 3.4.24.77 von Willebrand Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22781599&form=6&db=m [Increased susceptibility of recombinant type 2A von Willebrand factor mutant A1500E to proteolysis by ADAMTS13]. causal interaction,unassigned 1,0 3.4.24.77 von Willebrand Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27795521&form=6&db=m von Willebrand factor and von Willebrand disease. causal interaction,unassigned 4,0 3.4.24.77 Waldenstrom Macroglobulinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856553&form=6&db=m Matrix Metalloproteinase-8 Is Overexpressed in Waldenström's Macroglobulinemia Cells, and Specific Inhibition of this Metalloproteinase Blocks Release of Soluble CD27. ongoing research,therapeutic application,unassigned 1,2,0 3.4.24.77 Weill-Marchesani Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16472131&form=6&db=m ADAMTS Proteinases: Potential Therapeutic Targets? causal interaction,unassigned 3,0 3.4.24.77 Weill-Marchesani Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201140&form=6&db=m Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage. unassigned - 3.4.24.77 Weill-Marchesani Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30287421&form=6&db=m The RECK tumor-suppressor protein binds and stabilizes ADAMTS10. causal interaction,unassigned 4,0 3.4.24.77 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322316&form=6&db=m Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.77 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10924500&form=6&db=m Trimer carboxyl propeptide of collagen I produced by mature osteoblasts is chemotactic for endothelial cells. ongoing research,unassigned 1,0 3.4.24.77 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17915215&form=6&db=m Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I. therapeutic application,unassigned 2,0 3.4.24.77 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20445128&form=6&db=m Expression and Signaling of G Protein-Coupled Estrogen Receptor (GPER) in Rat Sertoli Cells. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.77 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21040752&form=6&db=m Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin. therapeutic application,unassigned 1,0 3.4.24.77 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23661704&form=6&db=m Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development. unassigned - 3.4.24.77 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697900&form=6&db=m The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. unassigned - 3.4.24.77 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22039045&form=6&db=m Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein-focal adhesion kinase (FAK) signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2478526&form=6&db=m Inhibitory effect of alpha 2-macroglobulin on Vibrio vulnificus protease. causal interaction,unassigned 2,0 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8789055&form=6&db=m Actions of Vibrio vulnificus metalloprotease on human plasma proteinase-proteinase inhibitor systems: a comparative study of native protease with its derivative modified by polyethylene glycol. unassigned - 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393733&form=6&db=m Functional domains of a zinc metalloprotease from Vibrio vulnificus. unassigned - 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10816513&form=6&db=m Metalloprotease is not essential for Vibrio vulnificus virulence in mice. causal interaction,unassigned 4,0 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628443&form=6&db=m Histamine-releasing reaction induced by the N-terminal domain of Vibrio vulnificus metalloprotease. ongoing research,unassigned 4,0 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726228&form=6&db=m High growing ability of Vibrio vulnificus biotype 1 is essential for production of a toxic metalloprotease causing systemic diseases in humans. causal interaction,unassigned 3,0 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644589&form=6&db=m The N-terminal propeptide of Vibrio vulnificus extracellular metalloprotease is both an inhibitor of and a substrate for the enzyme. unassigned - 3.4.24.77 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105518&form=6&db=m Development of an insect metalloproteinase inhibitor drug carrier system for application in chronic wound infections. therapeutic application,unassigned 4,0