3.4.24.46	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11708814&form=6&db=m	Inhibitory antibodies against endopeptidase activity of human adamalysin 19.	causal interaction,diagnostic usage,ongoing research,unassigned	2,2,3,0	
3.4.24.46	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8617717&form=6&db=m	Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.	diagnostic usage,ongoing research,unassigned	3,2,0	
3.4.24.46	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23649038&form=6&db=m	Biological Properties of Melanoma and Endothelial Cells after Plasmid AMEP Gene Electrotransfer Depend on Integrin Quantity on Cells.	ongoing research,unassigned	4,0	
3.4.24.46	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23980876&form=6&db=m	Gene Electrotransfer of Plasmid Antiangiogenic Metargidin Peptide (AMEP) in Disseminated Melanoma: Safety and Efficacy Results of a Phase I First-in-Man Study.	therapeutic application,unassigned	2,0	
3.4.24.46	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25781650&form=6&db=m	Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.	causal interaction,therapeutic application,unassigned	4,4,0	
3.4.24.46	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26072417&form=6&db=m	Antiangiogenic Metargidin Peptide (AMEP) Gene Therapy in Disseminated Melanoma.	therapeutic application,unassigned	3,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521103&form=6&db=m	Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors.	therapeutic application,unassigned	4,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9684866&form=6&db=m	The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.	therapeutic application,unassigned	1,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419777&form=6&db=m	Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.	unassigned	-	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12621058&form=6&db=m	Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.	ongoing research,unassigned	2,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14598310&form=6&db=m	ADAMs family members as amyloid precursor protein alpha-secretases.	causal interaction,therapeutic application,unassigned	1,4,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17028596&form=6&db=m	MicroRNAs and the hallmarks of cancer.	causal interaction,unassigned	3,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19718658&form=6&db=m	Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.	causal interaction,unassigned	1,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20064929&form=6&db=m	P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells.	causal interaction,unassigned	1,0	
3.4.24.46	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29963134&form=6&db=m	Tumor angiogenesis and anti-angiogenic gene therapy for cancer.	ongoing research,therapeutic application,unassigned	2,3,0	
3.4.24.46	Oligodendroglioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22406378&form=6&db=m	Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.	ongoing research,therapeutic application,unassigned	3,1,0	
3.4.24.46	Osteoarthritis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419777&form=6&db=m	Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.	unassigned	-	
3.4.24.46	Osteoarthritis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381768&form=6&db=m	Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,4,4,0	
3.4.24.46	Purpura, Thrombotic Thrombocytopenic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743117&form=6&db=m	Complement activation in diseases presenting with thrombotic microangiopathy.	causal interaction,therapeutic application,unassigned	1,1,0