3.4.22.45 Anemia, Hypochromic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23697374&form=6&db=m Effects of the crinivirus coat protein-interacting plant protein SAHH on post-transcriptional RNA silencing and its suppression. therapeutic application,unassigned 2,0 3.4.22.45 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843560&form=6&db=m RNA viruses and their silencing suppressors boost Abutilon mosaic virus, but not the Old World Tomato yellow leaf curl Sardinia virus. unassigned - 3.4.22.45 Foot-and-Mouth Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145088&form=6&db=m Efficient and stable expression of GFP through Wheat streak mosaic virus-based vectors in cereal hosts using a range of cleavage sites: formation of dense fluorescent aggregates for sensitive virus tracking. unassigned - 3.4.22.45 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21405985&form=6&db=m The helper component-proteinase cistron of Potato virus Y induces hypersensitivity and resistance in potato genotypes carrying dominant resistance genes on chromosome IV. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7831814&form=6&db=m 5' proximal potyviral sequences mediate potato virus X/potyviral synergistic disease in transgenic tobacco. unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9123832&form=6&db=m Genome amplification and long-distance movement functions associated with the central domain of tobacco etch potyvirus helper component-proteinase. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9268155&form=6&db=m Suppression of potyvirus infection by coexpressed closterovirus protein. unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10950988&form=6&db=m Native electrophoresis and Western blot analysis (NEWeB): a method for characterization of different forms of potyvirus particles and similar nucleoprotein complexes in extracts of infected plant tissues. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11517597&form=6&db=m [The primary role of central region of HC-pro of potato Y potyvirus in synergism of plant viruses] unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12206307&form=6&db=m Transgenic plants expressing HC-Pro show enhanced virus sensitivity while silencing of the transgene results in resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12416684&form=6&db=m Subcellular location of the helper component-proteinase of Cowpea aphid-borne mosaic virus. ongoing research,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12438624&form=6&db=m Long-distance movement, virulence, and RNA silencing suppression controlled by a single protein in hordei- and potyviruses: complementary functions between virus families. causal interaction,unassigned 3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12580279&form=6&db=m Localization of a potyvirus and the viral genome-linked protein in wild potato leaves at an early stage of systemic infection. unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15003867&form=6&db=m The potyviral suppressor of RNA silencing confers enhanced resistance to multiple pathogens. ongoing research,therapeutic application,unassigned 1,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15193921&form=6&db=m Functional replacement of Wheat streak mosaic virus HC-Pro with the corresponding cistron from a diverse array of viruses in the family Potyviridae. therapeutic application,unassigned 3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15806291&form=6&db=m A viral protein suppresses siRNA-directed interference in tobacco mosaic virus infection. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099919&form=6&db=m HcPro, a multifunctional protein encoded by a plant RNA virus, targets the 20S proteasome and affects its enzymic activities. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140783&form=6&db=m Complete deletion of Wheat streak mosaic virus HC-Pro: a null mutant is viable for systemic infection. therapeutic application,unassigned 3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540139&form=6&db=m Nested deletion analysis of Wheat streak mosaic virus HC-Pro: Mapping of domains affecting polyprotein processing and eriophyid mite transmission. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16894215&form=6&db=m Random mutagenesis of wheat streak mosaic virus HC-Pro: non-infectious interfering mutations in a gene dispensable for systemic infection of plants. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17617488&form=6&db=m Enhanced resistance and neutralization of defense responses by suppressors of RNA silencing. ongoing research,unassigned 3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17622640&form=6&db=m Potyvirus-induced gene silencing: the dynamic process of systemic silencing and silencing suppression. unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17980618&form=6&db=m Transient expression of HPV16 E7 peptide (aa 44-60) and HPV16 L2 peptide (aa 108-120) on chimeric potyvirus-like particles using Potato virus X-based vector. ongoing research,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18184062&form=6&db=m Phenotypes and functional effects caused by various viral RNA silencing suppressors in transgenic Nicotiana benthamiana and N. tabacum. causal interaction,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18474567&form=6&db=m Effects of viral silencing suppressors on tobacco ringspot virus infection in two Nicotiana species. ongoing research,unassigned 4,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18474568&form=6&db=m Purification of viral genome-linked protein VPg from potato virus A-infected plants reveals several post-translationally modified forms of the protein. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18943647&form=6&db=m Modifications of the Helper Component-Protease of Zucchini yellow mosaic virus for Generation of Attenuated Mutants for Cross Protection Against Severe Infection. therapeutic application,unassigned 3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18943658&form=6&db=m Soybean mosaic virus Helper Component-Protease Alters Leaf Morphology and Reduces Seed Production in Transgenic Soybean Plants. unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18943679&form=6&db=m Wheat streak mosaic virus Lacking Helper Component-Proteinase Is Competent to Produce Disease Synergism in Double Infections with Maize chlorotic mottle virus. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19322647&form=6&db=m N-terminal of Papaya ringspot virus type-W (PRSV-W) helper component proteinase (HC-Pro) is essential for PRSV systemic infection in zucchini. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20162445&form=6&db=m HC-Pro, a potyvirus RNA silencing suppressor, cancels cycling of Cucumber mosaic virus in Nicotiana benthamiana plants. diagnostic usage,unassigned 2,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20447282&form=6&db=m Helper component-proteinase (HC-Pro) protein of Papaya ringspot virus interacts with papaya calreticulin. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21309977&form=6&db=m Highly efficient virus resistance mediated by artificial microRNAs that target the suppressor of PVX and PVY in plants. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21525344&form=6&db=m Helper component proteinase of the genus Potyvirus is an interaction partner of translation initiation factors eIF(iso)4E and eIF4E and contains a 4E binding motif. diagnostic usage,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21899438&form=6&db=m A high level of transgenic viral small RNA is associated with broad potyvirus resistance in cucurbits. ongoing research,unassigned 2,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21970691&form=6&db=m The Cucumber vein yellowing virus silencing suppressor P1b can functionally replace HCPro in Plum pox virus infection in a host-specific manner. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513385&form=6&db=m Heterologous RNA-silencing suppressors from both plant- and animal-infecting viruses support plum pox virus infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489059&form=6&db=m Interaction of the Microtubule Associated Host Protein HIP2 with the Viral Helper Component Proteinase is Important in Infection with Potato Virus A. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23617337&form=6&db=m Fate of artificial microRNA-mediated resistance to plant viruses in mixed infections. unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24418553&form=6&db=m P3N-PIPO of Clover yellow vein virus exacerbates symptoms in pea infected with white clover mosaic virus and is implicated in viral synergism. causal interaction,unassigned 2,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24581046&form=6&db=m A procedure for the transient expression of genes by agroinfiltration above the permissive threshold to study temperature-sensitive processes in plant-pathogen interactions. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24804808&form=6&db=m Genetic analyses of the FRNK motif function of turnip mosaic virus uncover multiple and potentially interactive pathways of cross-protection. therapeutic application,unassigned 2,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24942578&form=6&db=m A novel role of the potyviral helper component proteinase contributes to enhance the yield of viral particles. unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25806948&form=6&db=m Roles and programming of Arabidopsis ARGONAUTE proteins during Turnip mosaic virus infection. causal interaction,therapeutic application,unassigned 2,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26313753&form=6&db=m High Temperature, High Ambient CO? Affect the Interactions between Three Positive-Sense RNA Viruses and a Compatible Host Differentially, but not Their Silencing Suppression Efficiencies. ongoing research,unassigned 2,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26641460&form=6&db=m Formation of Potato Virus A-Induced RNA Granules and Viral Translation Are Interrelated Processes Required for Optimal Virus Accumulation. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31509476&form=6&db=m Precise exchange of HC-Pro cistron between soybean mosaic virus and clover yellow vein virus: Impact on virus viability and host range specificity. causal interaction,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31647944&form=6&db=m DsRNA-mediated protection against two isolates of Papaya ringspot virus through topical application of dsRNA in papaya. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31730035&form=6&db=m Virus infection induces resistance to Pseudomonas syringae and to drought in both compatible and incompatible bacteria-host interactions, which are compromised under conditions of elevated temperature and CO2 levels. therapeutic application,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32053987&form=6&db=m Insights into the Functions of eIF4E-Biding Motif of VPg in Potato Virus A Infection. causal interaction,unassigned 4,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32594157&form=6&db=m Chilli veinal mottle virus HCPro interacts with catalase to facilitate virus infection in Nicotiana tabacum. therapeutic application,unassigned 2,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33031436&form=6&db=m The potyviral silencing suppressor HCPro recruits and employs host ARGONAUTE1 in pro-viral functions. causal interaction,unassigned 1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33045020&form=6&db=m Association of host protein VARICOSE with HCPro within a multiprotein complex is crucial for RNA silencing suppression, translation, encapsidation and systemic spread of potato virus A infection. causal interaction,ongoing research,unassigned 1,4,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100095292&form=6&db=m Wheat streak mosaic virus Lacking Helper Component-Proteinase Is Competent to Produce Disease Synergism in Double Infections with Maize chlorotic mottle virus diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100102569&form=6&db=m Soybean mosaic virus Helper Component-Protease Alters Leaf Morphology and Reduces Seed Production in Transgenic Soybean Plants unassigned - 3.4.22.45 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100102580&form=6&db=m Modifications of the Helper Component-Protease of Zucchini yellow mosaic virus for Generation of Attenuated Mutants for Cross Protection Against Severe Infection therapeutic application,unassigned 3,0 3.4.22.45 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760400&form=6&db=m Viral suppressors of RNA interference impair RNA silencing induced by a Semliki Forest virus replicon in tick cells. ongoing research,unassigned 2,0 3.4.22.45 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513385&form=6&db=m Heterologous RNA-silencing suppressors from both plant- and animal-infecting viruses support plum pox virus infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.22.45 Superinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27681136&form=6&db=m The Coat Protein and NIa Protease of Two Potyviridae Family Members Independently Confer Superinfection Exclusion. unassigned - 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12206307&form=6&db=m Transgenic plants expressing HC-Pro show enhanced virus sensitivity while silencing of the transgene results in resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12438624&form=6&db=m Long-distance movement, virulence, and RNA silencing suppression controlled by a single protein in hordei- and potyviruses: complementary functions between virus families. causal interaction,unassigned 3,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19237462&form=6&db=m Characterizing multiple exogenous and endogenous small RNA populations in parallel with subfemtomolar sensitivity using a streptavidin gel-shift assay. ongoing research,unassigned 4,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20447282&form=6&db=m Helper component-proteinase (HC-Pro) protein of Papaya ringspot virus interacts with papaya calreticulin. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21970691&form=6&db=m The Cucumber vein yellowing virus silencing suppressor P1b can functionally replace HCPro in Plum pox virus infection in a host-specific manner. therapeutic application,unassigned 1,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513385&form=6&db=m Heterologous RNA-silencing suppressors from both plant- and animal-infecting viruses support plum pox virus infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23927427&form=6&db=m Role of soybean mosaic virus-encoded proteins in seed and aphid transmission in soybean. causal interaction,unassigned 3,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736930&form=6&db=m HC-Pro Enhances the Activity of NtDXS and Promotes the Biosynthesis of Plastidic Isoprenoids in PVY-infected Tobacco. ongoing research,therapeutic application,unassigned 1,1,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29090655&form=6&db=m Potyviral Gene-Silencing Suppressor HCPro Interacts with Salicylic Acid (SA)-Binding Protein 3 to Weaken SA-Mediated Defense Responses. therapeutic application,unassigned 1,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30374036&form=6&db=m An atypical RNA silencing suppression strategy provides a snapshot of the evolution of sweet potato-infecting potyviruses. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30375150&form=6&db=m Ribosome profiles and riboproteomes of healthy and Potato virus A- and Agrobacterium-infected Nicotiana benthamiana plants. ongoing research,unassigned 2,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31847316&form=6&db=m A Novel Interaction Network Used by Potyviruses in Virus-Host Interactions at the Protein Level. unassigned - 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32251956&form=6&db=m Interaction of potyvirus helper component-proteinase (HcPro) with RuBisCO and nucleosome in viral infections of plants. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32594157&form=6&db=m Chilli veinal mottle virus HCPro interacts with catalase to facilitate virus infection in Nicotiana tabacum. therapeutic application,unassigned 2,0 3.4.22.45 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973838&form=6&db=m A Spontaneous Complementary Mutation Restores the RNA Silencing Suppression Activity of HC-Pro and the Virulence of Sugarcane Mosaic Virus. causal interaction,therapeutic application,unassigned 3,3,0