3.4.22.10 Anti-Glomerular Basement Membrane Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31563334&form=6&db=m The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease. unassigned - 3.4.22.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17907170&form=6&db=m Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.22.10 Arthritis, Infectious http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453639&form=6&db=m Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.10 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453639&form=6&db=m Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.10 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15043862&form=6&db=m Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.22.10 Cellulitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453639&form=6&db=m Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.10 Exanthema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3926872&form=6&db=m The production of pyrogenic exotoxins by group A streptococci. unassigned - 3.4.22.10 Fasciitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9620418&form=6&db=m Diagnosis of group A streptococcal necrotizing fasciitis by using PCR to amplify the streptococcal pyrogenic exotoxin B gene. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.22.10 Fasciitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10681429&form=6&db=m Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease. causal interaction,unassigned 2,0 3.4.22.10 Foodborne Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21750972&form=6&db=m Time course of virulence factors produced by group A streptococcus during a food-borne epidemic. ongoing research,unassigned 2,0 3.4.22.10 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9331617&form=6&db=m Role of streptococcal proteinase in acute post-streptococcal glomerulonephritis. causal interaction,unassigned 1,0 3.4.22.10 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9734606&form=6&db=m Immunohistochemical and serological evidence for the role of streptococcal proteinase in acute post-streptococcal glomerulonephritis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.10 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16105042&form=6&db=m Is the nephritogenic antigen in post-streptococcal glomerulonephritis pyrogenic exotoxin B (SPE B) or GAPDH? causal interaction,diagnostic usage,unassigned 2,2,0 3.4.22.10 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17637712&form=6&db=m Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.22.10 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23302723&form=6&db=m Bacterial infection-related glomerulonephritis in adults. causal interaction,unassigned 1,0 3.4.22.10 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064502&form=6&db=m Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8562741&form=6&db=m Clinical and microbiological characteristics of severe group A streptococcus infections and streptococcal toxic shock syndrome. causal interaction,unassigned 1,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9691092&form=6&db=m Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553627&form=6&db=m Substrate specificity of the streptococcal cysteine protease. unassigned - 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12160165&form=6&db=m Antibody to streptococcal cysteine proteinase as a seromarker of group A Streptococcal (Streptococcus pyogenes) infections. therapeutic application,unassigned 1,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15043862&form=6&db=m Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16329996&form=6&db=m Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis. causal interaction,unassigned 2,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980693&form=6&db=m Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB. unassigned - 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174338&form=6&db=m Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis. causal interaction,unassigned 4,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19712682&form=6&db=m Structure of the mature streptococcal cysteine protease exotoxin mSpeB in its active dimeric form. causal interaction,unassigned 2,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22040048&form=6&db=m An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes. causal interaction,unassigned 3,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22610375&form=6&db=m Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23383045&form=6&db=m Determining antibody-binding site of streptococcal pyrogenic exotoxin B to protect mice from group a streptococcus infection. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24799625&form=6&db=m Metal-mediated modulation of streptococcal cysteine protease activity and its biological implications. causal interaction,unassigned 2,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25629609&form=6&db=m Application of the c3-binding motif of streptococcal pyrogenic exotoxin B to protect mice from invasive group a streptococcal infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27181595&form=6&db=m Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage. unassigned - 3.4.22.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28923955&form=6&db=m Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen. causal interaction,unassigned 4,0 3.4.22.10 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641794&form=6&db=m Streptococcal cysteine protease augments lung injury induced by products of group A streptococci. ongoing research,unassigned 4,0 3.4.22.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689226&form=6&db=m Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.10 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20841492&form=6&db=m A possible rare cause of renal failure in streptococcal infection. unassigned - 3.4.22.10 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064502&form=6&db=m Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.22.10 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3926872&form=6&db=m The production of pyrogenic exotoxins by group A streptococci. unassigned - 3.4.22.10 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132182&form=6&db=m Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients. ongoing research,unassigned 1,0 3.4.22.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453639&form=6&db=m Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2198264&form=6&db=m Nucleotide sequence of the streptococcal pyrogenic exotoxin type B gene and relationship between the toxin and the streptococcal proteinase precursor. unassigned - 3.4.22.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613483&form=6&db=m The potential role of bacterial superantigens in the pathogenesis of Kawasaki syndrome. unassigned - 3.4.22.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613491&form=6&db=m Molecular structure of staphylococcus and streptococcus superantigens. unassigned - 3.4.22.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453639&form=6&db=m Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065540&form=6&db=m Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B/streptococcal cysteine protease. causal interaction,ongoing research,unassigned 2,3,0 3.4.22.10 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9125588&form=6&db=m Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion. causal interaction,therapeutic application,unassigned 4,3,0 3.4.22.10 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123674&form=6&db=m Life in protein-rich environments: the relA-independent response of Streptococcus pyogenes to amino acid starvation. ongoing research,therapeutic application,unassigned 1,1,0 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9673282&form=6&db=m Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection. ongoing research,unassigned 2,0 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11035746&form=6&db=m Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases. causal interaction,unassigned 1,0 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065540&form=6&db=m Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B/streptococcal cysteine protease. causal interaction,ongoing research,unassigned 2,3,0 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15043862&form=6&db=m Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15232159&form=6&db=m Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16950917&form=6&db=m Identification and characterization of bicistronic speB and prsA gene expression in the group A Streptococcus. causal interaction,unassigned 4,0 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17029726&form=6&db=m Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines. unassigned - 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22610375&form=6&db=m Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.4.22.10 Streptococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25629609&form=6&db=m Application of the c3-binding motif of streptococcal pyrogenic exotoxin B to protect mice from invasive group a streptococcal infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0