3.4.21.B26	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737405&form=6&db=m	The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
3.4.21.B26	Anorectal Malformations	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480163&form=6&db=m	PCSK5 and GDF11 Expression in the Hindgut Region of Mouse Embryos with Anorectal Malformations.	unassigned	-	
3.4.21.B26	Anorectal Malformations	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23127126&form=6&db=m	Anorectal atresia and variants at predicted regulatory sites in candidate genes.	diagnostic usage,unassigned	2,0	
3.4.21.B26	Anorectal Malformations	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446132&form=6&db=m	Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.	unassigned	-	
3.4.21.B26	Anorectal Malformations	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28975535&form=6&db=m	Spatiotemporal expression of proprotein convertase subtilisin/kexin type 5 in the development of anorectal malformations in fetal rats.	ongoing research,unassigned	4,0	
3.4.21.B26	Anus, Imperforate	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446132&form=6&db=m	Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.	unassigned	-	
3.4.21.B26	Atherosclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21889147&form=6&db=m	Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.	causal interaction,unassigned	3,0	
3.4.21.B26	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29161592&form=6&db=m	Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.	therapeutic application,unassigned	1,0	
3.4.21.B26	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737405&form=6&db=m	The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
3.4.21.B26	Cardiovascular Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20031622&form=6&db=m	Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels.	causal interaction,diagnostic usage,unassigned	3,3,0	
3.4.21.B26	Cardiovascular Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681612&form=6&db=m	Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.21.B26	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21094132&form=6&db=m	Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5.	diagnostic usage,unassigned	1,0	
3.4.21.B26	Endometrial Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22390935&form=6&db=m	Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.	causal interaction,diagnostic usage,ongoing research,unassigned	2,1,2,0	
3.4.21.B26	Esophageal Atresia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446132&form=6&db=m	Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.	unassigned	-	
3.4.21.B26	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19995186&form=6&db=m	The role of furin in papillomavirus infection.	ongoing research,therapeutic application,unassigned	2,1,0	
3.4.21.B26	Influenza in Birds	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33820827&form=6&db=m	Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.	causal interaction,unassigned	1,0	
3.4.21.B26	Nasal Polyps	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25350918&form=6&db=m	Proprotein Convertase 5/6A is Associated with BMP-2-induced Squamous Cell Differentiation.	unassigned	-	
3.4.21.B26	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24818756&form=6&db=m	Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,2,4	
3.4.21.B26	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29161592&form=6&db=m	Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.	therapeutic application,unassigned	1,0	
3.4.21.B26	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737405&form=6&db=m	The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
3.4.21.B26	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21094132&form=6&db=m	Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5.	diagnostic usage,unassigned	1,0	
3.4.21.B26	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22390935&form=6&db=m	Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.	causal interaction,diagnostic usage,ongoing research,unassigned	2,1,2,0	
3.4.21.B26	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23409034&form=6&db=m	Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,1,0	
3.4.21.B26	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24818756&form=6&db=m	Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,2,4	
3.4.21.B26	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26167473&form=6&db=m	Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
3.4.21.B26	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31695792&form=6&db=m	Comprehensive characterization of the alternative splicing landscape in head and neck squamous cell carcinoma reveals novel events associated with tumorigenesis and the immune microenvironment.	diagnostic usage,ongoing research,therapeutic application,unassigned	4,3,1,0	
3.4.21.B26	Neuroinflammatory Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942293&form=6&db=m	Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix.	causal interaction,ongoing research,unassigned	1,2,0	
3.4.21.B26	Osteoporosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33313955&form=6&db=m	MicroRNA?338?3p regulates age?associated osteoporosis via targeting PCSK5.	diagnostic usage,therapeutic application,unassigned	3,1,0	
3.4.21.B26	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9738000&form=6&db=m	PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,4,1,0	
3.4.21.B26	Takayasu Arteritis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25604533&form=6&db=m	Genome-wide association study identifies susceptibility loci in IL6, RPS9/LILRB3, and an intergenic locus on chromosome 21q22 in Takayasu's arteritis.	causal interaction,diagnostic usage,unassigned	2,3,0	
3.4.21.B26	Tracheoesophageal Fistula	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446132&form=6&db=m	Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.	unassigned	-	
3.4.21.B26	Vaccinia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9242664&form=6&db=m	Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.	ongoing research,unassigned	4,0	
3.4.21.B26	Vaccinia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10037747&form=6&db=m	Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.	ongoing research,unassigned	1,0