3.4.17.23 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33351362&form=6&db=m [Androgens and Antiandrogens influence on COVID-19 disease in men]. causal interaction,unassigned 3,0 3.4.17.23 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32924827&form=6&db=m Potential protease inhibitors and their combinations to block SARS-CoV-2. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34393265&form=6&db=m Computational studies reveal Fluorine based quinolines to be potent inhibitors for proteins involved in SARS-CoV-2 assembly. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926157&form=6&db=m Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18223026&form=6&db=m Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. causal interaction,unassigned 2,0 3.4.17.23 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685221&form=6&db=m Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33153216&form=6&db=m Novel Evidence of Acute Kidney Injury in COVID-19. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358501&form=6&db=m Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935396&form=6&db=m Acute Kidney Injury in COVID-19: a Brief Review. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448662&form=6&db=m The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926065&form=6&db=m [Effect of endotoxin on expression of angiotensin converting enzyme-2 in cultured rat pulmonary microvascular endothelial cells.] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021774&form=6&db=m Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis. causal interaction,unassigned 3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19564552&form=6&db=m Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851091&form=6&db=m Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23321685&form=6&db=m Osthole protects lipopolysaccharide-induced acute lung injury in mice by preventing down-regulation of angiotensin-converting enzyme 2. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23949470&form=6&db=m Angiotensin-(1-7) Protects From Experimental Acute Lung Injury. ongoing research,therapeutic application,unassigned 4,4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24662240&form=6&db=m Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus. causal interaction,unassigned 2,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25166885&form=6&db=m Mesenchymal stem cell-based angiotensin-converting enzyme 2 in treatment of acute lung injury rat induced by bleomycin. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25391767&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25419634&form=6&db=m MSCs with ACE II gene affect apoptosis pathway of acute lung injury induced by bleomycin. ongoing research,unassigned 4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25768373&form=6&db=m Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25890286&form=6&db=m Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. causal interaction,unassigned 4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25896672&form=6&db=m Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing SMAD2 Phosphorylation. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26146467&form=6&db=m Molecular and cellular mechanisms of the inhibitory effects of ACE-2/ANG1-7/Mas axis on lung injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26356266&form=6&db=m Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing MiR-4262. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822530&form=6&db=m Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats. causal interaction,unassigned 4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26938051&form=6&db=m ACE2 Antagonizes VEGFa to Reduce Vascular Permeability During Acute Lung Injury. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27158411&form=6&db=m Crosstalk between ACE2 and PLGF regulates vascular permeability during acute lung injury. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27302421&form=6&db=m Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-?B signaling pathways. causal interaction,ongoing research,unassigned 3,2,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27513359&form=6&db=m Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386354&form=6&db=m microRNA-1246 mediates lipopolysaccharide-induced pulmonary endothelial cell apoptosis and acute lung injury by targeting angiotensin-converting enzyme 2. ongoing research,unassigned 3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28877748&form=6&db=m A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29691582&form=6&db=m [ACE2 agonist DIZE alleviates lung injury induced by limb ischemia-reperfusion in mice]. ongoing research,unassigned 4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31356776&form=6&db=m Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK/mTOR signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805278&form=6&db=m ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway. ongoing research,therapeutic application,unassigned 3,2,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540737&form=6&db=m Use of pioglitazone in people with type 2 diabetes mellitus with coronavirus disease 2019 (COVID-19): Boon or bane? causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550040&form=6&db=m Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32866470&form=6&db=m The angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32947193&form=6&db=m Dyspneic and non-dyspneic (silent) hypoxemia in COVID-19: Possible neurological mechanism. causal interaction,unassigned 4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33461019&form=6&db=m Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33747178&form=6&db=m Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102962&form=6&db=m The roles of vitamin D in increasing the body's immunity and reducing injuries due to viral infections: With an emphasis on its possible role in SARS-CoV-2 (COVID-19). causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34521972&form=6&db=m Author Correction: Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-?B signaling pathways. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745466&form=6&db=m The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17804708&form=6&db=m Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338334&form=6&db=m The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19212105&form=6&db=m Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression. causal interaction,unassigned 4,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19465903&form=6&db=m Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736744&form=6&db=m Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23512661&form=6&db=m ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. causal interaction,unassigned 1,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24445296&form=6&db=m Commentary on "ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients." Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z, Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, USA.: Genes Dev 2013;27(6):683-98. causal interaction,unassigned 1,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468052&form=6&db=m Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705281&form=6&db=m Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193689&form=6&db=m TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421977&form=6&db=m Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609069&form=6&db=m Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33850935&form=6&db=m Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257580&form=6&db=m Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28433633&form=6&db=m Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195212&form=6&db=m The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma Patients. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292131&form=6&db=m Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421977&form=6&db=m Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33429366&form=6&db=m Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33809983&form=6&db=m Comparative Investigation of Composition, Antifungal, and Anti-Inflammatory Effects of the Essential Oil from Three Industrial Hemp Varieties from Italian Cultivation. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168096&form=6&db=m In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214467&form=6&db=m Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34361576&form=6&db=m Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.4.17.23 Adenocarcinoma, Mucinous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19465903&form=6&db=m Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.17.23 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33657582&form=6&db=m Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Ageusia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142989&form=6&db=m Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17021266&form=6&db=m Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.17.23 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408475&form=6&db=m New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 3.4.17.23 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756098&form=6&db=m Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.17.23 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29974954&form=6&db=m Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia. diagnostic usage,unassigned 2,0 3.4.17.23 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32977355&form=6&db=m Androgen Receptor Genetic Variant Predicts COVID-19 Disease Severity: A Prospective Longitudinal Study of Hospitalized COVID-19 Male Patients. causal interaction,unassigned 4,0 3.4.17.23 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33351362&form=6&db=m [Androgens and Antiandrogens influence on COVID-19 disease in men]. causal interaction,unassigned 3,0 3.4.17.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884212&form=6&db=m Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-? and tau pathology. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052346&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33567524&form=6&db=m Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34476120&form=6&db=m SARS-CoV-2, the Angiotensin Converting Enzyme 2 (ACE2) Receptor and Alzheimer's disease. causal interaction,unassigned 3,0 3.4.17.23 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29974954&form=6&db=m Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia. diagnostic usage,unassigned 2,0 3.4.17.23 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29974954&form=6&db=m Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia. diagnostic usage,unassigned 2,0 3.4.17.23 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25237166&form=6&db=m Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25237166&form=6&db=m Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417604&form=6&db=m Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2). causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34474710&form=6&db=m Effect of COVID-19 on hereditary angioedema activity and quality of life. causal interaction,unassigned 4,0 3.4.17.23 Angioedemas, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34474710&form=6&db=m Effect of COVID-19 on hereditary angioedema activity and quality of life. causal interaction,unassigned 4,0 3.4.17.23 angiotensin-converting enzyme 2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21252069&form=6&db=m Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 angiotensin-converting enzyme 2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21968754&form=6&db=m Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. unassigned - 3.4.17.23 angiotensin-converting enzyme 2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23671869&form=6&db=m Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 angiotensin-converting enzyme 2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30207087&form=6&db=m Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 angiotensin-converting enzyme 2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32532804&form=6&db=m COVID-19 and relative angiotensin-converting enzyme 2 deficiency: role in disease severity and therapeutic response. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 angiotensin-converting enzyme 2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177593&form=6&db=m A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency. causal interaction,unassigned 3,0 3.4.17.23 angiotensin-converting enzyme 2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307408&form=6&db=m Retinal Microcirculation as a Correlate of a Systemic Capillary Impairment After Severe Acute Respiratory Syndrome Coronavirus 2 Infection. causal interaction,unassigned 4,0 3.4.17.23 Anosmia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32817004&form=6&db=m Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0 3.4.17.23 Anosmia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942748&form=6&db=m SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System? causal interaction,unassigned 1,0 3.4.17.23 Anosmia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254514&form=6&db=m Nasal lavage containing Angiotensin-Converting Enzyme-2 agonist can prevent and reduce viral load in COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 Anosmia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33437144&form=6&db=m Anosmia and COVID-19: perspectives on its association and the pathophysiological mechanisms involved. unassigned - 3.4.17.23 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301841&form=6&db=m Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms. unassigned - 3.4.17.23 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602068&form=6&db=m Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm. diagnostic usage,therapeutic application,unassigned 2,2,0 3.4.17.23 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935757&form=6&db=m Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.17.23 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30850299&form=6&db=m Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33600934&form=6&db=m Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms. unassigned - 3.4.17.23 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31607667&form=6&db=m Plasma ACE2 Activity Predicts Mortality in Aortic Stenosis and Is Associated With Severe Myocardial Fibrosis. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32874745&form=6&db=m Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0 3.4.17.23 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26470648&form=6&db=m Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21053061&form=6&db=m Inflammation Alters Angiotensin Converting Enzymes (ACE and ACE-2) Balance in Rat Heart. ongoing research,unassigned 4,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27343405&form=6&db=m Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348692&form=6&db=m COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422146&form=6&db=m Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32914945&form=6&db=m Angiotensin Converting Enzyme-2 (ACE2) receptors, asthma and severe COVID-19 infection risk. causal interaction,unassigned 4,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065601&form=6&db=m Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33315853&form=6&db=m Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33413387&form=6&db=m Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33557817&form=6&db=m Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937568&form=6&db=m COVID-19 and bronchial asthma: current perspectives. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34198852&form=6&db=m Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity. causal interaction,unassigned 2,0 3.4.17.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34503323&form=6&db=m Asthma and COVID-19 pandemic: focused on the eosinophil count and ACE2 expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.17.23 Asymptomatic Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232770&form=6&db=m Regulation of the Expression of SARS-CoV-2 Receptor Angiotensin-Converting Enzyme 2 in Nasal Mucosa. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16116029&form=6&db=m Immunolocalization of ACE2 and AT2 Receptors in Rabbit Atherosclerotic Plaques. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18660448&form=6&db=m Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021774&form=6&db=m Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis. causal interaction,unassigned 3,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21252069&form=6&db=m Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22647892&form=6&db=m Activation of the Renin-Angiotensin system mediates the effects of dietary salt intake on atherogenesis in the apolipoprotein E knockout mouse. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22947420&form=6&db=m Angiotensin converting enzyme 2 and atherosclerosis. unassigned - 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24193738&form=6&db=m Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26304699&form=6&db=m Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27220756&form=6&db=m Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27615597&form=6&db=m Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28186543&form=6&db=m Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29066981&form=6&db=m Hydrogen Sulfide Attenuates Atherosclerosis in a Partially Ligated Carotid Artery Mouse model via Regulating Angiotensin Converting Enzyme 2 Expression. therapeutic application,unassigned 2,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30326474&form=6&db=m Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30850299&form=6&db=m Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953401&form=6&db=m The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33539861&form=6&db=m Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 3.4.17.23 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17254576&form=6&db=m Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation. unassigned - 3.4.17.23 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17961427&form=6&db=m [Effects of angiotensin converting enzyme inhibitor on the expression of angiotensin converting enzyme 2 in atrium of patients with atrial fibrillation] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22381157&form=6&db=m N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery. diagnostic usage,unassigned 2,0 3.4.17.23 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24342297&form=6&db=m Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27738071&form=6&db=m Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32984892&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.17.23 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31645418&form=6&db=m A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice. unassigned - 3.4.17.23 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27469059&form=6&db=m Overexpression of AT2R in the solitary-vagal complex improves baroreflex in the spontaneously hypertensive rat. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Brain Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33643747&form=6&db=m COVID-19 Encephalopathy in Adults. causal interaction,unassigned 3,0 3.4.17.23 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34124808&form=6&db=m Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30792990&form=6&db=m Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411754&form=6&db=m Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953840&form=6&db=m Erratum to dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2. unassigned - 3.4.17.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178900&form=6&db=m SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.17.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33593260&form=6&db=m Cross talk between COVID-19 and breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.17.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413267&form=6&db=m The potential role of abnormal angiotensin-converting enzyme 2 expression correlated with immune infiltration after SARS-CoV-2 infection in the prognosis of breast cancer. causal interaction,unassigned 3,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485450&form=6&db=m Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380080&form=6&db=m Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. causal interaction,unassigned 2,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16428450&form=6&db=m Phenotypic analysis of mice lacking the Tmprss2-encoded protease. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338334&form=6&db=m The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408932&form=6&db=m What is the molecular pathology of low-risk prostate cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20232485&form=6&db=m The role of chromosome 21 in hematology and oncology. therapeutic application,unassigned 1,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24764242&form=6&db=m Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277342&form=6&db=m In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090091&form=6&db=m TMPRSS2-ERG fusions linked to prostate cancer racial health disparities: A focus on Africa. causal interaction,unassigned 2,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32873700&form=6&db=m Gene of the month: TMPRSS2 (transmembrane serine protease 2). unassigned - 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609069&form=6&db=m Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34477955&form=6&db=m Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11414763&form=6&db=m Mutation analyses of 268 candidate genes in human tumor cell lines. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16428450&form=6&db=m Phenotypic analysis of mice lacking the Tmprss2-encoded protease. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17032499&form=6&db=m TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. diagnostic usage,unassigned 1,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19465903&form=6&db=m Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19642730&form=6&db=m Molecular biology underlying the clinical heterogeneity of prostate cancer: an update. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736744&form=6&db=m Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21743959&form=6&db=m Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers. diagnostic usage,ongoing research,unassigned 2,1,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469092&form=6&db=m ERG rearrangement and protein expression in the progression to castration-resistant prostate cancer. unassigned - 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656528&form=6&db=m Prostatic adenocarcinoma CNS parenchymal and dural metastases: alterations in ERG, CHD1 and MAP3K7 expression. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32374427&form=6&db=m Expression of the COVID-19 receptor ACE2 in the human conjunctiva. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468052&form=6&db=m Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421977&form=6&db=m Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609069&form=6&db=m Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131396&form=6&db=m Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.4.17.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34160253&form=6&db=m Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat. therapeutic application,unassigned 4,0 3.4.17.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023337&form=6&db=m ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421977&form=6&db=m Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34369278&form=6&db=m Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204277&form=6&db=m The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23545945&form=6&db=m Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition. causal interaction,unassigned 3,0 3.4.17.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636159&form=6&db=m Association between Serum Angiotensin-converting Enzyme 2 Level with Postoperative Morbidity and Mortality after Major Pulmonary Resection in Non-small Cell Lung Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.17.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023337&form=6&db=m ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330620&form=6&db=m Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.17.23 Carcinoma, Small Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19465903&form=6&db=m Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.17.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32374427&form=6&db=m Expression of the COVID-19 receptor ACE2 in the human conjunctiva. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468052&form=6&db=m Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468052&form=6&db=m Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20300067&form=6&db=m Inhibition of Angiotensin-Converting Enzyme 2 Exacerbates Cardiac Hypertrophy and Fibrosis in Ren-2 Hypertensive Rats. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946695&form=6&db=m Role of angiotensin-converting enzyme 2 in cardiac hypertrophy induced by nitric oxide synthase inhibition. causal interaction,unassigned 4,0 3.4.17.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23155428&form=6&db=m Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24067190&form=6&db=m Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. therapeutic application,unassigned 2,0 3.4.17.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26857347&form=6&db=m Activation of the Cardiac Renin-Angiotensin System in High Oxygen-Exposed Newborn Rats: Angiotensin Receptor Blockade Prevents the Developmental Programming of Cardiac Dysfunction. causal interaction,unassigned 1,0 3.4.17.23 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718423&form=6&db=m Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.17.23 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19700132&form=6&db=m Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.17.23 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445944&form=6&db=m Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22497476&form=6&db=m Olmesartan medoxomil treatment potently improves cardiac myosin-induced dilated cardiomyopathy via the modulation of ACE-2 and ANG 1-7 mas receptor. therapeutic application,unassigned 4,0 3.4.17.23 Cardiomyopathy, Hypertrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18208662&form=6&db=m Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy. causal interaction,unassigned 3,0 3.4.17.23 Cardiomyopathy, Hypertrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18560893&form=6&db=m Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy. causal interaction,unassigned 3,0 3.4.17.23 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32579957&form=6&db=m SARS-CoV-2 and cardiovascular complications: From molecular mechanisms to pharmaceutical management. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32789839&form=6&db=m Cardiovascular disease during the COVID-19 pandemic: Think ahead, protect hearts, reduce mortality. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492138&form=6&db=m Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16049057&form=6&db=m Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164957&form=6&db=m ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18391097&form=6&db=m Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. unassigned - 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21685445&form=6&db=m Cerebroprotection by angiotensin (1-7) in endothelin-1 induced ischemic stroke. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21859683&form=6&db=m Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 2. ongoing research,unassigned 1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21880865&form=6&db=m Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays. causal interaction,unassigned 3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23328447&form=6&db=m Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. unassigned - 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23608648&form=6&db=m Angiotensin-converting enzyme 2 activation improves endothelial function. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142453&form=6&db=m Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24861775&form=6&db=m Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases. therapeutic application,unassigned 4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25070352&form=6&db=m ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25813276&form=6&db=m Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498282&form=6&db=m Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia. therapeutic application,unassigned 2,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27615597&form=6&db=m Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27617176&form=6&db=m ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity. therapeutic application,unassigned 4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423630&form=6&db=m Insufficient hypothalamic angiotensin-converting enzyme 2 is associated with hypertension in SHR rats. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445944&form=6&db=m Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30056001&form=6&db=m The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population. causal interaction,unassigned 3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31093387&form=6&db=m SHOX Duplication and Tall Stature in a Patient with Xq Deletion and Vascular Disease. unassigned - 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215613&form=6&db=m Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations. causal interaction,unassigned 3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32216172&form=6&db=m Coronavirus uses as binding site in humans angiotensin-converting enzyme 2 functional receptor that is involved in arterial blood pressure control and fibrotic response to damage and is a drug target in cardiovascular disease. Is this just a phylogenetic coincidence? causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267499&form=6&db=m The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease. causal interaction,unassigned 1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32984892&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33017071&form=6&db=m Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin-converting enzyme 2 in patients with cardiovascular disease. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33029102&form=6&db=m The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275517&form=6&db=m Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones. causal interaction,unassigned 3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33462706&form=6&db=m Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study. causal interaction,unassigned 1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469835&form=6&db=m Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513487&form=6&db=m Prediction of death status on the course of treatment in SARS-COV-2 patients with deep learning and machine learning methods. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33539861&form=6&db=m Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617712&form=6&db=m Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019. therapeutic application,unassigned 1,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681251&form=6&db=m Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33688409&form=6&db=m Cardiovascular Manifestations of COVID-19. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33750913&form=6&db=m Overexpression of angiotensin-converting enzyme 2 by renin-angiotensin system inhibitors. Truth or myth? A systematic review of animal studies. therapeutic application,unassigned 2,0 3.4.17.23 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34038630&form=6&db=m The COVID-19 pandemic, heart and cardiovascular diseases: What we have learned. causal interaction,unassigned 1,0 3.4.17.23 Cerebral Amyloid Angiopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884212&form=6&db=m Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-? and tau pathology. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30056001&form=6&db=m The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population. causal interaction,unassigned 3,0 3.4.17.23 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513532&form=6&db=m Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Chagas Cardiomyopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652140&form=6&db=m Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33975613&form=6&db=m COVID-19 and periodontitis: reflecting on a possible association. causal interaction,unassigned 1,0 3.4.17.23 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32913009&form=6&db=m Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936693&form=6&db=m Men and COVID-19: A Pathophysiologic Review. unassigned - 3.4.17.23 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33100902&form=6&db=m Mica Can Alleviate TNBS-Induced Colitis in Mice by Reducing Angiotensin II and IL-17A and Increasing Angiotensin-Converting Enzyme 2, Angiotensin 1-7, and IL-10. ongoing research,therapeutic application,unassigned 2,2,0 3.4.17.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468052&form=6&db=m Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257580&form=6&db=m Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.17.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17367471&form=6&db=m Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas. diagnostic usage,unassigned 3,0 3.4.17.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675312&form=6&db=m ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33024750&form=6&db=m Gastrointestinal insights during the COVID-19 epidemic. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479506&form=6&db=m High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.17.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249149&form=6&db=m Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecular mimicry phenomena? Two not mutually exclusive hypotheses. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257580&form=6&db=m Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.17.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577652&form=6&db=m SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models. causal interaction,unassigned 1,0 3.4.17.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968645&form=6&db=m Pulmonary vascular endothelial injury and acute pulmonary hypertension caused by COVID-19: the fundamental cause of refractory hypoxemia? causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33051304&form=6&db=m Similarities in Risk for COVID-19 and Cancer Disparities. causal interaction,unassigned 4,0 3.4.17.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33082267&form=6&db=m Dysregulation of Angiotensin Converting Enzyme 2 Expression and Function in Comorbid Disease Conditions Possibly Contributes to Coronavirus Infectious Disease 2019 Complication Severity. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33216184&form=6&db=m Risk for COVID-19 infection in patients with tobacco smoke-associated cancers of the upper and lower airway. causal interaction,unassigned 1,0 3.4.17.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33415017&form=6&db=m Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34274504&form=6&db=m Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology. causal interaction,unassigned 2,0 3.4.17.23 Conjunctivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32880786&form=6&db=m Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye. ongoing research,unassigned 1,0 3.4.17.23 Connective Tissue Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20470389&form=6&db=m Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases. ongoing research,unassigned 2,0 3.4.17.23 Connective Tissue Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33369650&form=6&db=m Decreased serum ACE2 levels in patients with connective tissue diseases. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18753062&form=6&db=m [Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.17.23 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29897923&form=6&db=m Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18753062&form=6&db=m [Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.17.23 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142614&form=6&db=m The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16772384&form=6&db=m Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108019&form=6&db=m Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974127&form=6&db=m Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection. ongoing research,unassigned 4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19297479&form=6&db=m Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24027332&form=6&db=m Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Mediated by the Transmembrane Serine Protease TMPRSS2. ongoing research,unassigned 1,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27733646&form=6&db=m Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28778717&form=6&db=m TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30626688&form=6&db=m TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32167153&form=6&db=m Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? therapeutic application,unassigned 3,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584199&form=6&db=m Human and novel coronavirus infections in children: a review. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32713161&form=6&db=m The potential effects of DPP-4 inhibitors on cardiovascular system in COVID-19 patients. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714386&form=6&db=m COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges. ongoing research,unassigned 1,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982622&form=6&db=m Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33101175&form=6&db=m SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33130103&form=6&db=m The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33153403&form=6&db=m Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection? causal interaction,unassigned 1,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33175635&form=6&db=m Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33185582&form=6&db=m COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy? ongoing research,therapeutic application,unassigned 1,2,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278516&form=6&db=m ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,3 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330620&form=6&db=m Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33351362&form=6&db=m [Androgens and Antiandrogens influence on COVID-19 disease in men]. causal interaction,unassigned 3,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33638807&form=6&db=m MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19. unassigned - 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33719829&form=6&db=m COVID-19 and human reproduction: A pandemic that packs a serious punch. unassigned - 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33802310&form=6&db=m Immunogenetic Predictors of Severe COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811309&form=6&db=m Myasthenia gravis at the crossroad of COVID-19: focus on immunological and respiratory interplay. unassigned - 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34118974&form=6&db=m Severe COVID-19 in Alzheimer's disease: APOE4's fault again? causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136758&form=6&db=m Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34416436&form=6&db=m A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17. unassigned - 3.4.17.23 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34511698&form=6&db=m Binding of SARS-COV-2 (COVID-19) and SARS-COV to human ACE2: Identifying binding sites and consequences on ACE2 stiffness. therapeutic application,unassigned 1,0 3.4.17.23 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334052&form=6&db=m Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418728&form=6&db=m Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32578794&form=6&db=m Sars-CoV-2: A clinical update - II. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.17.23 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33221318&form=6&db=m An overview of viruses discovered over the last decades and drug development for the current pandemic. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32129518&form=6&db=m Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32132184&form=6&db=m Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32141569&form=6&db=m COVID-19 (Novel Coronavirus 2019) - recent trends. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32165541&form=6&db=m Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32167747&form=6&db=m Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32187421&form=6&db=m COVID-19: social distancing, ACE 2 receptors, protease inhibitors and beyond? causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32200663&form=6&db=m COVID-19 and Cardiovascular Disease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32221983&form=6&db=m Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32228252&form=6&db=m COVID-19, ACE2, and the cardiovascular consequences. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32232976&form=6&db=m CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19). therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32250244&form=6&db=m Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269089&form=6&db=m ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. diagnostic usage,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276929&form=6&db=m TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283499&form=6&db=m Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32285293&form=6&db=m Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV. therapeutic application,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32299779&form=6&db=m What Is the Role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 Infection in Hypertensive Patients With Diabetes? causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32299780&form=6&db=m Angiotensin-Converting Enzyme 2 as the Molecular Bridge Between Epidemiologic and Clinical Features of COVID-19. diagnostic usage,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32301766&form=6&db=m Cardiovascular Pharmacology in the Time of COVID-19: A Focus on Angiotensin-Converting Enzyme 2. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32304146&form=6&db=m Response to recent commentaries regarding the involvement of angiotensin-converting enzyme 2 (ACE2) and renin-angiotensin system blockers in SARS-CoV-2 infections. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32305506&form=6&db=m Renin-angiotensin system at the heart of COVID-19 pandemic. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32329408&form=6&db=m Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32333199&form=6&db=m Coronavirus in Hematologic Malignancies: Targeting Molecules Beyond the Angiotensin-Converting Enzyme 2 (ACE2) Wall in COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32334052&form=6&db=m Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32335209&form=6&db=m Correspondence: Angiotensin-converting enzyme 2 coated nanoparticles containing respiratory masks, chewing gums and nasal filters may be used for protection against COVID-19 infection. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32339344&form=6&db=m Vascular skin symptoms in COVID-19: a french observational study. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32339776&form=6&db=m Covid-19, TMPRSS2, and whether android regulation affects pandemic virus gender incidence and age distribution of disease. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32340044&form=6&db=m The ACE-2 in COVID-19: Foe or Friend? causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32345362&form=6&db=m Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348692&form=6&db=m COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32350104&form=6&db=m COVID-19 and nicotine as a mediator of ACE-2. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32351121&form=6&db=m Evidence for Use or Disuse of Renin-Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32356628&form=6&db=m Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32358609&form=6&db=m The COVID-19 outbreak and the angiotensin-converting enzyme 2: too little or too much? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32362217&form=6&db=m In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria. therapeutic application,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32366279&form=6&db=m Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32369402&form=6&db=m Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2). ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32369872&form=6&db=m At the heart of COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32376099&form=6&db=m Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380453&form=6&db=m What dentists need to know about COVID-19. therapeutic application,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382146&form=6&db=m Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32387456&form=6&db=m Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388547&form=6&db=m Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32389117&form=6&db=m A Viewpoint on Angiotensin-Converting Enzyme 2, Anti-Hypertensives and Coronavirus Disease 2019 (COVID-19). ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393136&form=6&db=m Coronavirus Disease 2019 and the Cerebrovascular-Cardiovascular Systems: What Do We Know So Far? causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32396773&form=6&db=m Truncated human angiotensin converting enzyme 2; a potential inhibitor of SARS-CoV-2 spike glycoprotein and potent COVID-19 therapeutic agent. ongoing research,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32397951&form=6&db=m The expression level of angiotensin-converting enzyme 2 determines the severity of COVID-19: lung and heart tissue as targets. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32398625&form=6&db=m Coincidence of COVID-19 Infection and Smell-Taste Perception Disorders. therapeutic application,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32404436&form=6&db=m TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32405437&form=6&db=m Management recommendations for patients with chronic kidney disease during the novel coronavirus disease 2019 (COVID-19) epidemic. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410141&form=6&db=m Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32415494&form=6&db=m COVID-19 pandemic and therapy with ibuprofen or renin-angiotensin system blockers: no need for interruptions or changes in ongoing chronic treatments. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418199&form=6&db=m Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418532&form=6&db=m Counter-regulatory 'Renin-Angiotensin' System-based Candidate Drugs to Treat COVID-19 Diseases in SARS-CoV-2-infected patients. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418728&form=6&db=m Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422146&form=6&db=m Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422280&form=6&db=m Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32423095&form=6&db=m The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428113&form=6&db=m Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE). unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428864&form=6&db=m Angiotensin converting enzyme-2 as therapeutic target in COVID-19. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32430431&form=6&db=m Smoking, ACE-2 and COVID-19: ongoing controversies. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32430651&form=6&db=m The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32432519&form=6&db=m Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)? ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437018&form=6&db=m TMPRSS2: Potential Biomarker for COVID-19 Outcomes. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437244&form=6&db=m Let's talk about sex in the context of COVID-19. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32438331&form=6&db=m Diabetes and metabolic syndrome as risk factors for COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32438383&form=6&db=m Inhaled modified angiotensin converting enzyme 2 (ACE2) as a decoy to mitigate SARS-CoV-2 infection. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442082&form=6&db=m Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32447630&form=6&db=m COVID-19 and the nervous system. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32449034&form=6&db=m Preventing transmission among operating room staff during COVID-19 pandemic: the role of the Aerosol Box and other personal protective equipment. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450087&form=6&db=m ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma-implications for COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450334&form=6&db=m The interplay of hypertension, ACE-2 and SARS-CoV-2: Emerging data as the "Ariadne's thread" for the "labyrinth" of COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32451913&form=6&db=m Obesity and COVID-19: ACE 2, the Missing Tile. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459372&form=6&db=m COVID-19 and renin-angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) - Is there any scientific evidence for controversy? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32469255&form=6&db=m SARS-CoV-2 perturbs the renin-angiotensin system and energy metabolism. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32470547&form=6&db=m Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost. ongoing research,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482249&form=6&db=m No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32491073&form=6&db=m The Effect of Coronavirus Disease 2019 on Cardiovascular Diseases. therapeutic application,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497637&form=6&db=m Analysis of Gastrointestinal and Hepatic Manifestations of SARS-CoV-2 Infection in 892 Patients in Queens, NY. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32498696&form=6&db=m COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32501810&form=6&db=m ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32503821&form=6&db=m SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human Chromosome 1. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32503822&form=6&db=m Human Gene Sequences in SARS-CoV-2 and Other Viruses. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32507883&form=6&db=m Covid-19: the renin-angiotensin system imbalance hypothesis. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508311&form=6&db=m COVID-19 and androgen-targeted therapy for prostate cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32510598&form=6&db=m Single-cell RNA analysis on ACE2 expression provides insights into SARS-CoV-2 potential entry into the bloodstream and heart injury. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32511360&form=6&db=m Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32511393&form=6&db=m ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32511460&form=6&db=m Single-cell Transcriptome Analysis Indicates New Potential Regulation Mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32511660&form=6&db=m Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32512290&form=6&db=m Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513532&form=6&db=m Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32525548&form=6&db=m Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32525600&form=6&db=m Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32526206&form=6&db=m SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32532804&form=6&db=m COVID-19 and relative angiotensin-converting enzyme 2 deficiency: role in disease severity and therapeutic response. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32534021&form=6&db=m The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32537478&form=6&db=m Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540737&form=6&db=m Use of pioglitazone in people with type 2 diabetes mellitus with coronavirus disease 2019 (COVID-19): Boon or bane? causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32544566&form=6&db=m ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32544884&form=6&db=m De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32549125&form=6&db=m Do sex-specific immunobiological factors and differences in angiotensin converting enzyme 2 (ACE2) expression explain increased severity and mortality of COVID-19 in males? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550040&form=6&db=m Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550243&form=6&db=m Prediction of repurposed drugs for treating lung injury in COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550259&form=6&db=m Coronavirus disease 2019 and cardiovascular system: A narrative review. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32558877&form=6&db=m Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32564908&form=6&db=m COVID-19 - Does This Disease Kill Due to Imbalance of the Renin Angiotensin System (RAS) Caused by Genetic and Gender Differences in the Response to Viral ACE 2 Attack? causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32566425&form=6&db=m Novel COVID-19: A Comprehensive Review of Transmission, Manifestation, and Pathogenesis. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32569293&form=6&db=m Biological sex impacts COVID-19 outcomes. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32572552&form=6&db=m [What is the importance of the conjunctiva as a potential transmission pathway for SARS-CoV-2 infections?] causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32574196&form=6&db=m ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32574273&form=6&db=m Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection? therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32574336&form=6&db=m The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577635&form=6&db=m Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577652&form=6&db=m SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32578011&form=6&db=m Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing's syndrome. diagnostic usage,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32582302&form=6&db=m Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584199&form=6&db=m Human and novel coronavirus infections in children: a review. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584474&form=6&db=m A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32586214&form=6&db=m The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32587974&form=6&db=m Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32588565&form=6&db=m Updates of Cardiovascular Manifestations in COVID-19: Korean Experience to Broaden Worldwide Perspectives. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32589459&form=6&db=m Ocular Surface Expression of SARS-CoV-2 Receptors. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32591346&form=6&db=m Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32593740&form=6&db=m Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32594472&form=6&db=m [Hypertension, RAAS blockade and risk in COVID-19 patients]. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32595762&form=6&db=m Involvement of digestive system in COVID-19: manifestations, pathology, management and challenges. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32596694&form=6&db=m An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32597377&form=6&db=m The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,3 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32598305&form=6&db=m Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)? causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32600476&form=6&db=m An Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes? causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32601125&form=6&db=m Potential role of endothelial cell surface ectopic redox complexes in COVID-19 disease pathogenesis. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32617987&form=6&db=m Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive review. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32620366&form=6&db=m COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32622449&form=6&db=m Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632717&form=6&db=m In Silico Screening of Potential Chinese Herbal Medicine Against COVID-19 by Targeting SARS-CoV-2 3CLpro and Angiotensin Converting Enzyme II Using Molecular Docking. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633594&form=6&db=m Could Anti-Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID-19 Infection? Data From Centers of Southern Italy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636018&form=6&db=m Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32637965&form=6&db=m Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32638018&form=6&db=m Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32639866&form=6&db=m Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655724&form=6&db=m Coronavirus Disease 2019: A Gastroenterologist's Perspective in May 2020. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32656452&form=6&db=m Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin-Converting Enzyme 2 Receptor. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32658591&form=6&db=m The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32660650&form=6&db=m Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32661206&form=6&db=m Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32664879&form=6&db=m New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,3 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32665234&form=6&db=m Drug treatments affecting ACE2 in COVID-19 infection: a systematic review protocol. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32669955&form=6&db=m A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32673509&form=6&db=m Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32673940&form=6&db=m EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675206&form=6&db=m Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675312&form=6&db=m ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676577&form=6&db=m A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676597&form=6&db=m Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis. ongoing research,therapeutic application,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676603&form=6&db=m Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676883&form=6&db=m COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32681935&form=6&db=m SARS-CoV-2 and the cardiovascular system. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685191&form=6&db=m The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685221&form=6&db=m Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32691334&form=6&db=m COVID-19 and Hartnup disease: an affair of intestinal amino acid malabsorption. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32691890&form=6&db=m ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32698190&form=6&db=m Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32699850&form=6&db=m Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703421&form=6&db=m Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32709978&form=6&db=m Crosstalk between COVID-19 and prostate cancer. causal interaction,ongoing research,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32710575&form=6&db=m Angiotensin converting enzyme 2 at the interface between renin-angiotensin system inhibition and coronavirus disease 2019. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32712124&form=6&db=m Delineating clinical characteristics and comorbidities among 206 COVID-19 deceased patients in India: Emerging significance of renin angiotensin system derangement. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714688&form=6&db=m Gastrointestinal Manifestations in COVID-19 Infection and Its Practical Applications. causal interaction,ongoing research,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32721181&form=6&db=m Immunometabolic Status of COVID-19 Cancer Patients. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32721806&form=6&db=m Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS). causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723427&form=6&db=m Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726325&form=6&db=m Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32729633&form=6&db=m COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32734518&form=6&db=m Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32736027&form=6&db=m Femoral Arterial Thrombosis in a Young Adult after Nonsevere COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32738184&form=6&db=m Tumor markers as an entry for SARS-CoV-2 infection? diagnostic usage,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32741259&form=6&db=m Identification of potential anti-TMPRSS2 natural products through homology modelling, virtual screening and molecular dynamics simulation studies. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32741970&form=6&db=m SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742838&form=6&db=m COVID-19 in Smokeless Tobacco Habitués: Increased Susceptibility and Transmission. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32743577&form=6&db=m Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32743793&form=6&db=m COVID-19 and diabetes mellitus: how one pandemic worsens the other. diagnostic usage,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32748331&form=6&db=m Physiological Relevance of Angiotensin Converting Enzyme 2 As a Metabolic Linker and Therapeutic Implication of Mesenchymal Stem Cells in COVID-19 and Hypertension. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32748812&form=6&db=m Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32750108&form=6&db=m Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755395&form=6&db=m MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32757420&form=6&db=m Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758625&form=6&db=m Role of comorbidities like diabetes on severe acute respiratory syndrome coronavirus-2: A review. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32764454&form=6&db=m SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32764907&form=6&db=m COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765938&form=6&db=m Potential Using of Fat-derived Stromal Cells in the Treatment of Active Disease, and also, in Both Pre- and Post-Periods in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32768223&form=6&db=m Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32778033&form=6&db=m Angiotensin-converting Enzyme 2 roles in the Pathogenesis of COVID-19. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32785086&form=6&db=m Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32791137&form=6&db=m ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32791255&form=6&db=m SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32791552&form=6&db=m [COVID-19 and the impact of cardiovascular comorbidities]. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793908&form=6&db=m Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793911&form=6&db=m Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32795093&form=6&db=m Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk. diagnostic usage,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32799423&form=6&db=m Effect of Common Medications on the Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32808850&form=6&db=m The Virological, Immunological, and Imaging Approaches for COVID-19 Diagnosis and Research. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32818905&form=6&db=m ACE2, Metformin, and COVID-19. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821885&form=6&db=m Potential Role of Peptide-Based Antiviral Therapy Against SARS-CoV-2 Infection. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32822426&form=6&db=m COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825469&form=6&db=m Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32831324&form=6&db=m Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32834893&form=6&db=m Does hereditary angioedema make COVID-19 worse? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835083&form=6&db=m Predicted therapeutic targets for COVID-19 disease by inhibiting SARS-CoV-2 and its related receptors. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32837754&form=6&db=m SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal-Fetal Interface. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32838195&form=6&db=m Protective Effects of CVD and DM Medications in SARS-CoV-2 Infection. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32839786&form=6&db=m SARS-CoV-2 Antibody Responses Correlate with Resolution of RNAemia But Are Short-Lived in Patients with Mild Illness. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32841215&form=6&db=m Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32843719&form=6&db=m A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844337&form=6&db=m Angiotensin-converting enzyme 2: a double-edged sword in COVID-19 patients with an increased risk of heart failure. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844538&form=6&db=m Alpha-1-antitrypsin: A possible host protective factor against Covid-19. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848446&form=6&db=m Coronavirus Disease 2019 (COVID-19) in Children: Prevalence, Diagnosis, Clinical Symptoms, and Treatment. diagnostic usage,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850607&form=6&db=m Racial and Gender-Based Differences in COVID-19. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850978&form=6&db=m Combination Therapy Using Inhalable GapmeR and Recombinant ACE2 for COVID-19. ongoing research,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32851855&form=6&db=m The interaction of SARS-CoV-2 and other coronavirus with Angiotensin Converting Enzyme 2 (ACE2) as their main receptor: therapeutic implications. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32861070&form=6&db=m ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32861340&form=6&db=m Targeting TMPRSS2 in SARS-CoV-2 Infection. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32862058&form=6&db=m Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863157&form=6&db=m Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32864545&form=6&db=m The Resilient Child: Sex-Steroid Hormones and COVID-19 Incidence in Pediatric Patients. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32864572&form=6&db=m Treatment Options Available for COVID-19 and an Analysis on Possible Role of Combination of rhACE2, Angiotensin (1-7) and Angiotensin (1-9) as Effective Therapeutic Measure. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32867305&form=6&db=m COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32871306&form=6&db=m COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge? ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32874745&form=6&db=m Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32876011&form=6&db=m Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32879112&form=6&db=m Potential pathogenesis of severe acute respiratory syndrome coronavirus 2. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32880786&form=6&db=m Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32883368&form=6&db=m A protein interaction map identifies existing drugs targeting SARS-CoV-2. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32887634&form=6&db=m SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32888876&form=6&db=m Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32891636&form=6&db=m MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32892197&form=6&db=m Expert Opinions on the Current Therapeutic Management of Inflammatory Bowel Disease during the COVID-19 Pandemic: Japan IBD COVID-19 Taskforce, Intractable Diseases, the Health and Labor Sciences Research. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903321&form=6&db=m Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32905897&form=6&db=m Understanding COVID-19: A hypothesis regarding digit ratio (2D:4D), ACE I/D polymorphism, oxygen metabolism and national case fatality rates. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908071&form=6&db=m Association of ACE2 receptor and ACEIs/ARBs with disease severity in COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909007&form=6&db=m Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32910704&form=6&db=m New normal: two aspects of adipose tissue in COVID-19-treat and threat? causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32913009&form=6&db=m Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32914945&form=6&db=m Angiotensin Converting Enzyme-2 (ACE2) receptors, asthma and severe COVID-19 infection risk. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917504&form=6&db=m Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917573&form=6&db=m Sex-mediated effects of ACE2 and TMPRSS2 on the incidence and severity of COVID-19; The need for genetic implementation. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32920066&form=6&db=m Angiotensin-converting enzyme 2, sex differences, and COVID-19: The missing link. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32921739&form=6&db=m Oncolytic effect of SARS-CoV2 in a patient with NK lymphoma. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32926920&form=6&db=m New insights on possible vaccine development against SARS-CoV-2. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32934806&form=6&db=m Prediction of repurposed drugs for treating lung injury in COVID-19. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32935109&form=6&db=m Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936429&form=6&db=m Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936693&form=6&db=m Men and COVID-19: A Pathophysiologic Review. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32940922&form=6&db=m Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats: implications on COVID 19 infections. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942748&form=6&db=m SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System? causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32945216&form=6&db=m Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers and Outcomes in patients with COVID-19: A Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953947&form=6&db=m SARS-CoV-2 infection: physiological and environmental gift factors at high altitude. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32956843&form=6&db=m Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32960480&form=6&db=m Ethnic differences in alpha-1 antitrypsin deficiency allele frequencies may partially explain national differences in COVID-19 fatality rates. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967703&form=6&db=m TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968798&form=6&db=m Unveiling COVID-19-associated organ-specific cell types and cell-specific pathway cascade. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973879&form=6&db=m Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32977355&form=6&db=m Androgen Receptor Genetic Variant Predicts COVID-19 Disease Severity: A Prospective Longitudinal Study of Hospitalized COVID-19 Male Patients. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32979436&form=6&db=m The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982622&form=6&db=m Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32984892&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987060&form=6&db=m Mechanisms and treatments of myocardial injury in patients with corona virus disease 2019. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32988772&form=6&db=m Antibodies at work in the time of severe acute respiratory syndrome coronavirus 2. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991251&form=6&db=m The COVID-19 Pandemic: A Global Health Crisis. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991819&form=6&db=m Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32992681&form=6&db=m Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico Analysis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32994673&form=6&db=m CoViD-19 Susceptibility. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995771&form=6&db=m Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995775&form=6&db=m Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein's Receptor Binding Domain and Recombinant Human ACE2. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995808&form=6&db=m DNA Methylation Architecture of the ACE2 gene in Nasal Cells. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32998451&form=6&db=m Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving? causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33004323&form=6&db=m COVID-19 and the kidney. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33005531&form=6&db=m The Role of Sex in the Risk of Mortality From COVID-19 Amongst Adult Patients: A Systematic Review. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006953&form=6&db=m Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015550&form=6&db=m SARS-CoV-2, an Underestimated Pathogen of the Nervous System. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015748&form=6&db=m What GI Physicians Need to Know During COVID-19 Pandemic. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33024750&form=6&db=m Gastrointestinal insights during the COVID-19 epidemic. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33024851&form=6&db=m Expression profiles of the SARS-CoV-2 host invasion genes in nasopharyngeal and oropharyngeal swabs of COVID-19 patients. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33029419&form=6&db=m Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)? causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33029570&form=6&db=m Molecular docking between human TMPRSS2 and SARS-CoV-2 spike protein: conformation and intermolecular interactions. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33032170&form=6&db=m SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33033170&form=6&db=m The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33034620&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With Coronavirus Disease 2019. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33036546&form=6&db=m Role of angiotensin-converting enzyme 2 and pericytes in cardiac complications of COVID-19 infection. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33039120&form=6&db=m [Association of hypertension and antihypertensive agents and the severity of COVID-19 pneumonia. A monocentric French prospective study]. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33042994&form=6&db=m Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043967&form=6&db=m Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33045350&form=6&db=m Azithromycin and ambroxol as potential pharmacotherapy for SARS-CoV-2. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33045777&form=6&db=m Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33046696&form=6&db=m Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049061&form=6&db=m Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049279&form=6&db=m Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049583&form=6&db=m GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050860&form=6&db=m COVID-19 and Renal Diseases: An Update. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33051304&form=6&db=m Similarities in Risk for COVID-19 and Cancer Disparities. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052333&form=6&db=m SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052346&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052350&form=6&db=m Regulation of the ACE2 locus in human airways cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057007&form=6&db=m ACE2 mouse models: a toolbox for cardiovascular and pulmonary research. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059040&form=6&db=m Benign Evolution of SARS-Cov2 Infections in Children With Inflammatory Bowel Disease: Results From Two International Databases. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059811&form=6&db=m [Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062952&form=6&db=m An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063674&form=6&db=m Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33064147&form=6&db=m Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065163&form=6&db=m Metabolic impact of weight loss induced reduction of adipose ACE-2 - Potential implication in COVID-19 infections? causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065278&form=6&db=m Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women? causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065601&form=6&db=m Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33066495&form=6&db=m Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19? causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33072093&form=6&db=m Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33072222&form=6&db=m Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33073694&form=6&db=m Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33077916&form=6&db=m Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33078369&form=6&db=m Neurobiochemical Cross-talk Between COVID-19 and Alzheimer's Disease. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33078484&form=6&db=m Atrial fibrillation in COVID-19: A review of possible mechanisms. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080435&form=6&db=m The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33081670&form=6&db=m Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33083800&form=6&db=m Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33083805&form=6&db=m Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33083808&form=6&db=m IgM autoantibodies recognizing ACE2 are associated with severe COVID-19. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33085491&form=6&db=m Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33086029&form=6&db=m Renin-angiotensin system at the interface of COVID-19 infection. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33086161&form=6&db=m The potential use of ABO blood group system for risk stratification of COVID-19. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33086866&form=6&db=m ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Serine Protease 2) Expression and Localization of SARS-CoV-2 Infection in the Human Heart. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33089707&form=6&db=m Potential neurological manifestations of COVID-19: a narrative review. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33101356&form=6&db=m Infectivity and Progression of COVID-19 Based on Selected Host Candidate Gene Variants. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33108836&form=6&db=m Coronavirus Disease 2019 Transmission: Blood Viremia and Aerosol Generation from Spinal Surgery. Is There an Increased Risk to the Surgical Team? causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33108902&form=6&db=m ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33111873&form=6&db=m COVID-19, Renin-Angiotensin System, Angiotensin-Converting Enzyme 2, and Nicotine: What is the Interrelation? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112187&form=6&db=m Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112891&form=6&db=m Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117379&form=6&db=m ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117437&form=6&db=m Testosterone in COVID-19 - Foe, Friend or Fatal Victim? causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33124044&form=6&db=m Are Migraine Patients at Increased Risk for Symptomatic Coronavirus Disease 2019 Due to Shared Comorbidities? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33124193&form=6&db=m Transcriptomic analysis reveals novel mechanisms of SARS-CoV-2 infection in human lung cells. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33125431&form=6&db=m Kidney ACE2 expression: Implications for chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33129880&form=6&db=m Is highly expressed ACE 2 in pregnant women "a curse" in times of COVID-19 pandemic? causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33130103&form=6&db=m The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33130280&form=6&db=m Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33134395&form=6&db=m Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33141332&form=6&db=m What is the significance of the conjunctiva as a potential transmission route for SARS-CoV-2 infections? causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142828&form=6&db=m Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142989&form=6&db=m Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33143053&form=6&db=m miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33145103&form=6&db=m Renin-Angiotensin System Inhibitors in COVID-19: Current Concepts. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33145296&form=6&db=m Analysis of 2019-nCoV receptor ACE2 expression in different tissues and its significance study. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33146121&form=6&db=m Case Report: Ischemic Colitis in Severe COVID-19 Pneumonia: An Unforeseen Gastrointestinal Complication. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33148439&form=6&db=m Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33151050&form=6&db=m Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152165&form=6&db=m Effects of SARS-CoV-2 infection on male sex-related hormones in recovering patients. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152201&form=6&db=m Effects of the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) on the nervous system. What can we expect from SARS -CoV-2? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33153403&form=6&db=m Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection? causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33154233&form=6&db=m Paediatric COVID-19 and the GUT. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33156843&form=6&db=m A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159236&form=6&db=m Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33164230&form=6&db=m Insights into disparities observed with COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33166657&form=6&db=m Clinically Suspected Myocarditis in the Course of Severe Acute Respiratory Syndrome Novel Coronavirus-2 Infection: Fact or Fiction? causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33168188&form=6&db=m Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33174576&form=6&db=m Context contribution to the intermolecular recognition of human ACE2-derived peptides by SARS-CoV-2 spike protein: implications for improving the peptide affinity but not altering the peptide specificity by optimizing indirect readout. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33175635&form=6&db=m Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176395&form=6&db=m Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33177276&form=6&db=m Aspiration of periodontopathic bacteria due to poor oral hygiene potentially contributes to the aggravation of COVID-19. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33177594&form=6&db=m SARS-CoV-2 receptor is co-expressed with elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33177848&form=6&db=m Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178033&form=6&db=m Physical Exercise and the Renin Angiotensin System: Prospects in the COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178900&form=6&db=m SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33181158&form=6&db=m From angiotensin-converting enzyme 2 disruption to thromboinflammatory microvascular disease: A paradigm drawn from COVID-19. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33183974&form=6&db=m COVID-19 susceptibility in pregnancy: Immune/inflammatory considerations, the role of placental ACE-2 and research considerations. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33185828&form=6&db=m Potential approaches to combat COVID-19: a mini-review. ongoing research,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33187703&form=6&db=m Associations between mortality from COVID-19 in two Italian regions and outdoor air pollution as assessed through tropospheric nitrogen dioxide. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33188579&form=6&db=m Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33191600&form=6&db=m Renin-angiotensin system inhibition and risk of infection and mortality in COVID-19: a systematic review and meta-analysis. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33192492&form=6&db=m COVID-19-Related Intracerebral Hemorrhage. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193689&form=6&db=m TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195331&form=6&db=m The Pursuit of COVID-19 Biomarkers: Putting the Spotlight on ACE2 and TMPRSS2 Regulatory Sequences. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195477&form=6&db=m Small Resistance Artery Disease and ACE2 in Hypertension: A New Paradigm in the Context of COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197204&form=6&db=m COVID-19-Associated Nonocclusive Fibrin Microthrombi in the Heart. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197881&form=6&db=m Role of angiotensin-converting enzyme 2 in neurodegenerative diseases during the COVID-19 pandemic. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33200131&form=6&db=m Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33200417&form=6&db=m The other side of COVID-19 pandemic: Effects on male fertility. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33202598&form=6&db=m The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33204291&form=6&db=m Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33205496&form=6&db=m Pharmacogenomics of genetic polymorphism within the genes responsible for SARS-CoV-2 susceptibility and the drug-metabolising genes used in treatment. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33206176&form=6&db=m Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33207244&form=6&db=m Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33210357&form=6&db=m ACE inhibitors, angiotensin receptor blockers and endothelial injury in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33216184&form=6&db=m Risk for COVID-19 infection in patients with tobacco smoke-associated cancers of the upper and lower airway. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33218024&form=6&db=m Target-Centered Drug Repurposing Predictions of Human Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine Subtype 2 (TMPRSS2) Interacting Approved Drugs for Coronavirus Disease 2019 (COVID-19) Treatment through a Drug-Target Interaction Deep Learning Model. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33228447&form=6&db=m Coronavirus Disease 2019-Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231569&form=6&db=m Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33231620&form=6&db=m ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19. causal interaction,therapeutic application,unassigned 2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33232769&form=6&db=m SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33233425&form=6&db=m ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33234760&form=6&db=m An unusual presentation of COVID-19: Acute pancreatitis. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33235538&form=6&db=m Plasma-activated water: An alternative disinfectant for S protein inactivation to prevent SARS-CoV-2 infection. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33236375&form=6&db=m Review of COVID-19 and male genital tract. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33237815&form=6&db=m Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33242628&form=6&db=m COVID-19 Susceptibility in Bronchial Asthma. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33242791&form=6&db=m A safety consideration of mesenchymal stem cell therapy on COVID-19. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33243086&form=6&db=m Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33243116&form=6&db=m Can Host Cell Proteins Like ACE2, ADAM17, TMPRSS2, Androgen Receptor be the Efficient Targets in SARS-CoV-2 Infection? causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33244168&form=6&db=m HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33244369&form=6&db=m The role of angiotensin-converting enzyme 2 (ACE2) receptor in the intestine in COVID-19: more research needed. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245471&form=6&db=m Expression and co-expression analyses of TMPRSS2, a key element in COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245731&form=6&db=m MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33253796&form=6&db=m The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254494&form=6&db=m Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254514&form=6&db=m Nasal lavage containing Angiotensin-Converting Enzyme-2 agonist can prevent and reduce viral load in COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254543&form=6&db=m Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254575&form=6&db=m Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33256833&form=6&db=m Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33257679&form=6&db=m Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33262177&form=6&db=m Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33263566&form=6&db=m Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33265982&form=6&db=m Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33268588&form=6&db=m Research progress in nervous system damage caused by SARS-CoV-2. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33269350&form=6&db=m Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275517&form=6&db=m Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275999&form=6&db=m A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278516&form=6&db=m ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,3 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281941&form=6&db=m The gut microbiome: an under-recognised contributor to the COVID-19 pandemic? causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33283602&form=6&db=m Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33284859&form=6&db=m SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33290397&form=6&db=m Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33290972&form=6&db=m In silico screening of potential anti-COVID-19 bioactive natural constituents from food sources by molecular docking. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33291720&form=6&db=m The Benefits of Vitamin D Supplementation for Athletes: Better Performance and Reduced Risk of COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33296096&form=6&db=m Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33296619&form=6&db=m Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300001&form=6&db=m SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300137&form=6&db=m Immunohistochemical expression of angiotensin-converting enzyme 2 in minor salivary glands during SARS-CoV-2 infection. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33303654&form=6&db=m A data-driven approach to identify risk profiles and protective drugs in COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304243&form=6&db=m Neuropathobiology of COVID-19: The Role for Glia. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304309&form=6&db=m Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33305790&form=6&db=m ACE2, a multifunctional protein - from cardiovascular regulation to COVID-19. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308506&form=6&db=m Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309398&form=6&db=m SARS-CoV-2: what it is, how it acts, and how it manifests in imaging studies. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310740&form=6&db=m Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker-Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310780&form=6&db=m Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310900&form=6&db=m Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33312199&form=6&db=m Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33318519&form=6&db=m Gene expression network analysis provides potential targets against SARS-CoV-2. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33318880&form=6&db=m Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33322198&form=6&db=m Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33323800&form=6&db=m Gene Expression of Angiotensin-Converting Enzyme 2 Receptor in Skin and the Implications for COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33328008&form=6&db=m [A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019]. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33329052&form=6&db=m Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330857&form=6&db=m Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330868&form=6&db=m Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33334050&form=6&db=m SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33336781&form=6&db=m Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33341894&form=6&db=m Potential benefits of dietary seaweeds as protection against COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33342421&form=6&db=m Possible therapeutic interventions in COVID-19 induced ARDS by cotinine as an ACE-2 promoter and AT-1R blocker. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33344513&form=6&db=m Pandemic Perspective: Commonalities Between COVID-19 and Cardio-Oncology. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33344912&form=6&db=m Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347477&form=6&db=m Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358501&form=6&db=m Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33359190&form=6&db=m Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33368788&form=6&db=m Classical and alternative receptors for SARS-CoV-2 therapeutic strategy. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33375616&form=6&db=m Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33380340&form=6&db=m ACE2: the molecular doorway to SARS-CoV-2. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33380345&form=6&db=m Cognitive impact of COVID-19: looking beyond the short term. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33380375&form=6&db=m Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19? causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381708&form=6&db=m Another perspective for COVID-19 pandemic: Angiotensin-converting enzyme 2 and ethnicity. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33382930&form=6&db=m Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33386398&form=6&db=m SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33389262&form=6&db=m COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33390724&form=6&db=m Pain as clinical manifestations of COVID-19 infection and its management in the pandemic era: a literature review. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33390952&form=6&db=m Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33390974&form=6&db=m Hydroxychloroquine as a Chemoprophylactic Agent for COVID-19: A Clinico-Pharmacological Review. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33391794&form=6&db=m ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33398633&form=6&db=m Identification of novel inhibitors of angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19). causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33399851&form=6&db=m Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33401657&form=6&db=m The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33405098&form=6&db=m Is COVID-19 Gender-sensitive? causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414908&form=6&db=m Dealing with lung cancer in the COVID-19 scenario (A review). causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33418950&form=6&db=m Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33419885&form=6&db=m Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421977&form=6&db=m Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33422990&form=6&db=m SARS-CoV-2 leads to a small vessel endotheliitis in the heart. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33423311&form=6&db=m Human SARS CoV-2 spike protein mutations. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33425294&form=6&db=m Computational Biology Analysis of COVID-19 Receptor-Binding Domains: A Target Site for Indocyanine Green Through Antimicrobial Photodynamic Therapy. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33426604&form=6&db=m ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33426683&form=6&db=m Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33434105&form=6&db=m SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33435547&form=6&db=m The Effects of COVID-19 on Placenta and Pregnancy: What Do We Know So Far? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33435929&form=6&db=m Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33436481&form=6&db=m Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33437137&form=6&db=m Combination and tricombination therapy to destabilize the structural integrity of COVID-19 by some bioactive compounds with antiviral drugs: insights from molecular docking study. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441348&form=6&db=m Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33442688&form=6&db=m Fibrinolysis influences SARS-CoV-2 infection in ciliated cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33447763&form=6&db=m Cardiovascular medications and regulation of COVID-19 receptors expression. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450625&form=6&db=m Host genomics of COVID-19: Evidence point towards Alpha 1 antitrypsin deficiency as a putative risk factor for higher mortality rate. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33459225&form=6&db=m Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33462543&form=6&db=m Role of indoor aerosols for COVID-19 viral transmission: a review. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33462706&form=6&db=m Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33463909&form=6&db=m 17?-estradiol reduces SARS-CoV-2 infection in vitro. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33465165&form=6&db=m Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33468620&form=6&db=m Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469197&form=6&db=m Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469527&form=6&db=m Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469581&form=6&db=m Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469649&form=6&db=m Exploring G protein-coupled receptors and yeast surface display strategies for viral detection in baker's yeast: SARS-CoV-2 as a case study. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33471720&form=6&db=m Considerations for Gut Microbiota and Probiotics in Patients with Diabetes Amidst the Covid-19 Pandemic: A Narrative Review. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33472206&form=6&db=m Ocular pathology and occasionally detectable intraocular SARS-CoV-2 RNA in five fatal COVID-19 cases. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33472675&form=6&db=m Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33475077&form=6&db=m COVID-19, Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Inhibition: Implications for Practice. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479506&form=6&db=m High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484868&form=6&db=m Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485182&form=6&db=m The effects of novel coronavirus (SARS-CoV-2) infection on cardiovascular diseases and cardiopulmonary injuries. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486116&form=6&db=m Drugs acting on the renin-angiotensin system and SARS-CoV-2. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33488517&form=6&db=m The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489355&form=6&db=m Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33499680&form=6&db=m Obesity considerations during the COVID-19 outbreak. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33500718&form=6&db=m Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33502950&form=6&db=m Soluble ACE2 as a potential therapy for COVID-19. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33505639&form=6&db=m Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33512650&form=6&db=m Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519145&form=6&db=m Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519467&form=6&db=m 3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519802&form=6&db=m Does Angiotensin II Peak in Response to SARS-CoV-2? ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33520014&form=6&db=m Two pronged approach for prevention and therapy of COVID-19 (Sars-CoV-2) by a multi-targeted herbal drug, a component of ayurvedic decoction. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33521687&form=6&db=m Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33521783&form=6&db=m Stroke in patients infected by the novel coronavirus and its causal mechanisms: A narrative review. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33522308&form=6&db=m Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524563&form=6&db=m Inhibitory efficiency of potential drugs against SARS-CoV-2 by blocking human angiotensin converting enzyme-2: Virtual screening and molecular dynamics study. ongoing research,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525252&form=6&db=m The role of angiotensin-converting enzyme 2 in COVID-19 induced lung injury. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33527003&form=6&db=m Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2). causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531686&form=6&db=m More light on cancer and COVID-19 reciprocal interaction. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33532767&form=6&db=m Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535011&form=6&db=m Delayed onset of fatal encephalitis in a COVID-19 positive patient. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33536425&form=6&db=m A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2. ongoing research,therapeutic application,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33536584&form=6&db=m Estrogen receptors are linked to angiotensin-converting enzyme 2 (ACE2), ADAM metallopeptidase domain 17 (ADAM-17), and transmembrane protease serine 2 (TMPRSS2) expression in the human atrium: insights into COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537555&form=6&db=m Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33539819&form=6&db=m SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33541739&form=6&db=m Differential Expression of Rab5 and Rab7 Small GTPase Proteins in Placental Tissues From Pregnancies Affected by Maternal Coronavirus Disease 2019. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542974&form=6&db=m Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33550782&form=6&db=m CNS implications of COVID-19: a comprehensive review. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33553222&form=6&db=m Vigilance on New-Onset Atherosclerosis Following SARS-CoV-2 Infection. diagnostic usage,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33557330&form=6&db=m SARS-CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33558541&form=6&db=m Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33563197&form=6&db=m The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33564039&form=6&db=m Histone deacetylase inhibitors suppress ACE2 and ABO simultaneously, suggesting a preventive potential against COVID-19. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33564221&form=6&db=m Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33566370&form=6&db=m A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33567524&form=6&db=m Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33573324&form=6&db=m Research Progress on the Cardiac Injury from ACE2 Targeting in SARS-CoV-2 Infection. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577324&form=6&db=m Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33581688&form=6&db=m Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19). causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33582450&form=6&db=m Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33584115&form=6&db=m Multiple relationships between aerosol and COVID-19: A framework for global studies. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33585826&form=6&db=m Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes. diagnostic usage,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33591607&form=6&db=m Implications of SARS-CoV-2 infection for neurogastroenterology. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33593260&form=6&db=m Cross talk between COVID-19 and breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33600934&form=6&db=m Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33607284&form=6&db=m Variants in ACE2; potential influences on virus infection and COVID-19 severity. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33608407&form=6&db=m SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609069&form=6&db=m Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609783&form=6&db=m Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611766&form=6&db=m Roux-en-Y Gastric Bypass Downregulates Angiotensin-Converting Enzyme 2 (ACE2) Gene Expression in Subcutaneous White Adipose Tissue: A Putative Protective Mechanism Against Severe COVID-19. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33612970&form=6&db=m Development of a SARS-CoV-2-derived receptor-binding domain-based ACE2 biosensor. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614688&form=6&db=m Decreased Mortality Rate Among COVID-19 Patients Prescribed Statins: Data From Electronic Health Records in the US. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614744&form=6&db=m Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617712&form=6&db=m Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619962&form=6&db=m Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV-2 Spike Proteins by ACE2-Designed Peptides. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33623738&form=6&db=m Renin-Angiotensin System Implications to COVID-19 Comorbidities. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33624300&form=6&db=m Akt-independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS-CoV2 infection. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33624358&form=6&db=m Suggestions on cleavage embryo and blastocyst vitrification/transfer based on expression profile of ACE2 and TMPRSS2 in current COVID-19 pandemic. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33624859&form=6&db=m Production of high-quality SARS-CoV-2 antigens: Impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33629341&form=6&db=m Differential expression and immune correlation analysis of COVID-19 receptor ACE2 and TMPRSS2 genes in all normal and tumor tissues. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33631122&form=6&db=m Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33632095&form=6&db=m Elucidating the drug repurposing spectra of COVID-19 with its analogues SARS and MERS. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33635001&form=6&db=m Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein. therapeutic application,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33637588&form=6&db=m Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33638460&form=6&db=m Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33639976&form=6&db=m Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649313&form=6&db=m TMPRSS2 activity may mediate sex differences in COVID-19 severity. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33654293&form=6&db=m Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33655087&form=6&db=m Mutations and polymorphisms in genes involved in the infections by covid 19: a review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33656713&form=6&db=m Relationship Between COVID-19 and Angiotensin-Converting Enzyme 2: A Scoping Review. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33657424&form=6&db=m Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33658420&form=6&db=m THE PECULIARITY OF COVID- 19 GENOME AND THE CORONAVIRUS RNA TRANSLATION PROCESS AS APOTENTIAL TARGET FOR ETIOTROPIC MEDICATIONSWITH ADENINE AND OTHER NUCLEOTIDE ANALOGUES (REVIEW). unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660945&form=6&db=m Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33662873&form=6&db=m The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664552&form=6&db=m Role of endothelial cell receptors in the context of SARS-CoV-2 infection (COVID-19). causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33666783&form=6&db=m Environmental Determinants of Coronavirus Disease 2019 (COVID-19). unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33668523&form=6&db=m Bioactive Alkaloids from Genus Aspergillus: Mechanistic Interpretation of Their Antimicrobial and Potential SARS-CoV-2 Inhibitory Activity Using Molecular Modelling. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33669132&form=6&db=m In Silico, In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell Fusion. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33676899&form=6&db=m Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. therapeutic application,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33677852&form=6&db=m Is multisystem inflammatory syndrome related with coronavirus disease 2019, Kawasaki disease, and angiotensin-converting enzyme 2 in children? causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33678444&form=6&db=m Pneumatosis Intestinalis Due to COVID-19 Infection in Kidney Transplant Recipient: A Case Report. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681723&form=6&db=m Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684975&form=6&db=m A Comprehensive Review of COVID-19 Associated Neurological Manifestations. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33688456&form=6&db=m Mapping COVID-19 with nuclear imaging: from infection to functional sequelae. diagnostic usage,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33692973&form=6&db=m SARS-CoV-2 and the Gastrointestinal Tract in Children. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33694125&form=6&db=m Colonic Epithelial Angiotensin-Converting Enzyme 2 (ACE2) Expression in Blacks and Whites: Potential Implications for Pathogenesis Covid-19 Racial Disparities. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33704002&form=6&db=m Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706683&form=6&db=m Potential inhibitors of angiotensin converting enzyme 2 receptor of COVID-19 by Corchorus olitorius Linn using docking, molecular dynamics, conceptual DFT investigation and pharmacophore mapping. ongoing research,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706759&form=6&db=m Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33707363&form=6&db=m Contributions of human ACE2 and TMPRSS2 in determining host-pathogen interaction of COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708781&form=6&db=m Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33713620&form=6&db=m Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33714595&form=6&db=m Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33718452&form=6&db=m Single-Cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33719829&form=6&db=m COVID-19 and human reproduction: A pandemic that packs a serious punch. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33723519&form=6&db=m Potency of Mesenchymal Stem Cell and Its Secretome in Treating COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33725828&form=6&db=m Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727353&form=6&db=m Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33728277&form=6&db=m Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33731252&form=6&db=m Physiological implications of COVID-19 in reproduction: angiotensin-converting enzyme 2 a key player. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732005&form=6&db=m Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732459&form=6&db=m Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732571&form=6&db=m Delayed hemodialysis in COVID-19: Case series with literature review. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33737851&form=6&db=m Smoking Enigma in Coronavirus Disease 2019: A Tug of War between Predisposition and Possible Way Out. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738043&form=6&db=m Angiotensin-converting enzyme 2 connects COVID-19 with cancer and cancer immunotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738305&form=6&db=m Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738989&form=6&db=m Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33741941&form=6&db=m Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33747178&form=6&db=m Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33748697&form=6&db=m Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33752217&form=6&db=m Variants in ACE2 and TMPRSS2 Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank Subjects. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754609&form=6&db=m Effects of COVID-19 on male sex function and its potential sexual transmission. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33758885&form=6&db=m Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2). causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777663&form=6&db=m Survived COVID-19 patient presented with death on arrival: A case report. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33782449&form=6&db=m DNA methylation architecture of the ACE2 gene in nasal cells of children. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33784482&form=6&db=m A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786727&form=6&db=m Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors. therapeutic application,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33789993&form=6&db=m The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33796097&form=6&db=m Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33802310&form=6&db=m Immunogenetic Predictors of Severe COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33804075&form=6&db=m Renal Manifestations of Covid-19: Physiology and Pathophysiology. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33809851&form=6&db=m The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811212&form=6&db=m Genetic variability in COVID-19-related genes in the Brazilian population. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33815295&form=6&db=m The Efficacy and Potential Mechanisms of Metformin in the Treatment of COVID-19 in the Diabetics: A Systematic Review. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33816521&form=6&db=m Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33819740&form=6&db=m The contrasting role of nasopharyngeal angiotensin converting enzyme 2 (ACE2) transcription in SARS-CoV-2 infection: A cross-sectional study of people tested for COVID-19 in British Columbia, Canada. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33824130&form=6&db=m Novel Coronavirus-2019 (2019-nCoV): Perspectives of emergence, prophylaxis and predicted treatment approaches. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33824725&form=6&db=m Genetic variability in COVID-19-related genes in the Brazilian population. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33828231&form=6&db=m From bedside to bench: regulation of host factors in SARS-CoV-2 infection. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33831468&form=6&db=m In silico analysis of the potential mechanism of a preventive Chinese medicine formula on coronavirus disease 2019. diagnostic usage,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833750&form=6&db=m COVID-19-A Theory of Autoimmunity Against ACE-2 Explained. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33835386&form=6&db=m Scientific Hypothesis for Treatment of COVID-19's Lung Lesions by Adjusting ACE/ACE2 Imbalance. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840836&form=6&db=m The identification of novel inhibitors of human angiotensin-converting enzyme 2 and main protease of Sars-Cov-2: A combination of in silico methods for treatment of COVID-19. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33844653&form=6&db=m Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33847382&form=6&db=m Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33848207&form=6&db=m Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33850112&form=6&db=m Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33850482&form=6&db=m Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa. ongoing research,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851521&form=6&db=m Short-term effects of COVID-19 on semen parameters: A multicenter study of 69 cases. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33853637&form=6&db=m Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33855640&form=6&db=m Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesis. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33868239&form=6&db=m Genetics Insight for COVID-19 Susceptibility and Severity: A Review. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33872774&form=6&db=m Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33875979&form=6&db=m Classical and Counter-Regulatory Renin-Angiotensin System: Potential Key Roles in COVID-19 Pathophysiology. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33886504&form=6&db=m Does taking an angiotensin inhibitor increase the risk for COVID-19? - a systematic review and meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893249&form=6&db=m Angiotensin-converting Enzyme 2 Specific Cell Subset Identification in Oral Tissues: A Need of the Hour in COVID-19 Research. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893649&form=6&db=m Tackling Covid-19 using disordered-to-order transition of residues in the spike protein upon angiotensin-converting enzyme 2 binding. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33894177&form=6&db=m Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33897423&form=6&db=m 1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33897916&form=6&db=m Making a complex dental care tailored to the person: population health in focus of predictive, preventive and personalised (3P) medical approach. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33901540&form=6&db=m Will a little change do you good? A putative role of polymorphisms in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33903855&form=6&db=m Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33908317&form=6&db=m Letter to the Editor: COVID-19 utilization of ACE-2 receptor to enter the host cell. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33909265&form=6&db=m Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33912588&form=6&db=m The Deadly Duo of COVID-19 and Cancer! causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33912790&form=6&db=m Isolation of a human monoclonal antibody specific for the receptor binding domain of SARS-CoV-2 using a competitive phage biopanning strategy. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33914873&form=6&db=m Animal Models of COVID-19 II. Comparative Immunology. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33915773&form=6&db=m BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19. ongoing research,therapeutic application,unassigned 2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33920724&form=6&db=m Current Status of Putative Animal Sources of SARS-CoV-2 Infection in Humans: Wildlife, Domestic Animals and Pets. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33920790&form=6&db=m Cardiovascular Outcomes in the Acute Phase of COVID-19. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921689&form=6&db=m Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33922918&form=6&db=m SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33926110&form=6&db=m Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33926967&form=6&db=m Sex differences in the induction of angiotensin converting enzyme 2 (ACE-2) in mouse lungs after e-cigarette vapor exposure and its relevance to COVID-19. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33927933&form=6&db=m COVID-19 Vaccine and Hyperosmolar Hyperglycemic State. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33934196&form=6&db=m Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935396&form=6&db=m Acute Kidney Injury in COVID-19: a Brief Review. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935803&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus 2 and Male Reproduction: Relationship, Explanations, and Clinical Remedies. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33939057&form=6&db=m COVID-19 and the pituitary. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33941272&form=6&db=m COVID-19 and Alzheimer's disease: how one crisis worsens the other. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33946649&form=6&db=m ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33951227&form=6&db=m The role and significance of angiotensin-converting enzyme 2 peptides in the treatment of coronavirus disease 2019. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33957057&form=6&db=m The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33958627&form=6&db=m Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33958841&form=6&db=m Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33959029&form=6&db=m The Role of Renin-Angiotensin-Aldosterone System in the Heart and Lung: Focus on COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33962399&form=6&db=m Low plasma angiotensin-converting enzyme 2 level in diabetics increases the risk of severe COVID-19 infection. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33962629&form=6&db=m Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33963054&form=6&db=m ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33964216&form=6&db=m ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33965375&form=6&db=m The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33967772&form=6&db=m SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33968142&form=6&db=m Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33975613&form=6&db=m COVID-19 and periodontitis: reflecting on a possible association. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33978563&form=6&db=m From cellular function to global impact: the vascular perspective on COVID-19. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33979162&form=6&db=m Critical Interactions Between the SARS-CoV-2 Spike Glycoprotein and the Human ACE2 Receptor. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33982445&form=6&db=m A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19. ongoing research,therapeutic application,unassigned 2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33982646&form=6&db=m Problems associated with antiviral drugs and vaccines development for COVID-19: approach to intervention using expression vectors via GPI anchor. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984310&form=6&db=m Computational optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984877&form=6&db=m Role of ACE2 polymorphism in COVID-19: impact of age. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33987176&form=6&db=m The Mechanisms and Animal Models of SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33992187&form=6&db=m Post-COVID 19 neurological syndrome: Implications for sequelae's treatment. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995847&form=6&db=m Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33998180&form=6&db=m Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33998404&form=6&db=m [Cardiac Involvement in COVID-19]. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34000358&form=6&db=m Abnormal apelin-ACE2 and SGLT2 signaling contribute to adverse cardiorenal injury in patients with COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34001248&form=6&db=m Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34004207&form=6&db=m Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34009036&form=6&db=m A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34009691&form=6&db=m Genome-wide screening of SARS-CoV-2 infection-related genes based on the blood leukocytes sequencing data set of patients with COVID-19. diagnostic usage,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34010445&form=6&db=m Endocrine and metabolic aspects of COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34012391&form=6&db=m Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34015585&form=6&db=m COVID-19 and metabolic comorbidities: An update on emerging evidences for optimal therapies. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34016010&form=6&db=m Quantitative assessment of retinal changes in COVID-19 patients. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34016183&form=6&db=m Genetic susceptibility of COVID-19: a systematic review of current evidence. diagnostic usage,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34016740&form=6&db=m Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34022205&form=6&db=m Endothelial cell dysfunction, coagulation, and angiogenesis in coronavirus disease 2019 (COVID-19). diagnostic usage,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34023987&form=6&db=m Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34029937&form=6&db=m Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031621&form=6&db=m Molecular basis of the new COVID-19 target neuropilin-1 in complex with SARS-CoV-2 S1 C-end rule peptide and small-molecule antagonists. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34032435&form=6&db=m Lipid Nanoparticle RBD-hFc mRNA Vaccine Protects hACE2 Transgenic Mice against a Lethal SARS-CoV-2 Infection. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34038630&form=6&db=m The COVID-19 pandemic, heart and cardiovascular diseases: What we have learned. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34045511&form=6&db=m Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34047305&form=6&db=m Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34047940&form=6&db=m COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential development. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34048906&form=6&db=m Do inflammaging and coagul-aging play a role as conditions contributing to the co-occurrence of the severe hyper-inflammatory state and deadly coagulopathy during COVID-19 in older people? causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34054974&form=6&db=m A Correlation among the COVID-19 Spread, Particulate Matters, and Angiotensin-Converting Enzyme 2: A Review. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34060982&form=6&db=m H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34063247&form=6&db=m Scutellaria barbata D. Don Inhibits the Main Proteases (Mpro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34064066&form=6&db=m Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34066226&form=6&db=m Pathophysiological Association of Endothelial Dysfunction with Fatal Outcome in COVID-19. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34068221&form=6&db=m Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis. causal interaction,ongoing research,unassigned 2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073591&form=6&db=m Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34075330&form=6&db=m A variant in TMPRSS2 is associated with decreased disease severity in COVID-19. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34079039&form=6&db=m JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34079691&form=6&db=m Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34083848&form=6&db=m A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19-Recovered Patients as a Probable Therapy for COVID-19. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089595&form=6&db=m Do Anti-androgens Have Potential as Therapeutics for COVID-19? causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094635&form=6&db=m Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell Level. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094637&form=6&db=m Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal Cells. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094930&form=6&db=m High Expression of ACE2 and TMPRSS2 at the Resection Margin Makes Lung Cancer Survivors Susceptible to SARS-CoV-2 With Unfavorable Prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34100014&form=6&db=m Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102600&form=6&db=m A tale of two diseases: Sarcoidosis, COVID-19 and new therapeutic options with dual RAS inhibition and tetanus-diphtheria vaccine. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102962&form=6&db=m The roles of vitamin D in increasing the body's immunity and reducing injuries due to viral infections: With an emphasis on its possible role in SARS-CoV-2 (COVID-19). causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34109284&form=6&db=m Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34113632&form=6&db=m Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34116393&form=6&db=m Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2). causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34118289&form=6&db=m Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34118974&form=6&db=m Severe COVID-19 in Alzheimer's disease: APOE4's fault again? causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34122126&form=6&db=m Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34123321&form=6&db=m Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies. diagnostic usage,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34124612&form=6&db=m A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34130536&form=6&db=m Acute Pancreatitis in a Patient With COVID-19 After the Resolution of Respiratory Symptoms. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131396&form=6&db=m Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131661&form=6&db=m A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136074&form=6&db=m Different kinds of stem cells in the development of SARS-CoV-2 treatments. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136537&form=6&db=m Association of ACEi/ARB Use and Clinical Outcomes of COVID-19 Patients With Hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136758&form=6&db=m Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34137173&form=6&db=m Single-cell RNA sequencing identify SDCBP in ACE2-positive bronchial epithelial cells negatively correlates with COVID-19 severity. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34138483&form=6&db=m Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34141737&form=6&db=m COVID-19 and the digestive system: A comprehensive review. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34146659&form=6&db=m TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34150335&form=6&db=m Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151392&form=6&db=m The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34155611&form=6&db=m Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34159616&form=6&db=m TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34160253&form=6&db=m Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34166652&form=6&db=m TRP channels in COVID-19 disease: Potential targets for prevention and treatment. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168096&form=6&db=m In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168732&form=6&db=m New perspectives on angiotensin-converting enzyme 2 and its related diseases. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34172713&form=6&db=m In silico screening of Allium cepa phytochemicals for their binding abilities to SARS and SARS-CoV-2 3C-like protease and COVID-19 human receptor ACE-2. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34172790&form=6&db=m Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34176080&form=6&db=m Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177593&form=6&db=m A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178377&form=6&db=m The COVID-19 Menace. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179075&form=6&db=m Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179347&form=6&db=m Discovery of Small Anti-ACE2 Peptides to Inhibit SARS-CoV-2 Infectivity. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34180562&form=6&db=m miRNAs; a novel strategy for the treatment of COVID-19. ongoing research,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34189359&form=6&db=m Severe Epistaxis after Tissue Plasminogen Activator administration for Acute Ischemic Stroke in SARS-COV-2 Infection. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195465&form=6&db=m Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195965&form=6&db=m Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201415&form=6&db=m Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34205044&form=6&db=m Type-2 Diabetes as a Risk Factor for Severe COVID-19 Infection. diagnostic usage,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34209110&form=6&db=m Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-Containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34211811&form=6&db=m COVID-19 With an Initial Presentation of Intraperitoneal Hemorrhage Secondary to Spontaneous Splenic Rupture. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34213568&form=6&db=m Development of IgG, IgM, and IgA autoantibodies against angiotensin converting enzyme 2 in patients with COVID-19. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214467&form=6&db=m Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34217121&form=6&db=m Evaluation of vertical transmission of SARS-CoV-2 in utero: Nine pregnant women and their newborns. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34217771&form=6&db=m Is diabetes mellitus a wrongdoer to COVID-19 severity? causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34224085&form=6&db=m Modulation of ACE-2 mRNA by inflammatory cytokines in human thyroid cells: a pilot study. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34227468&form=6&db=m Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34228902&form=6&db=m Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34229582&form=6&db=m The molecular dynamics of possible inhibitors for SARS-CoV-2. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230933&form=6&db=m Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232425&form=6&db=m COVID-19 and male reproductive system: pathogenic features and possible mechanisms. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34233672&form=6&db=m Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34241583&form=6&db=m Erratum: Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34248940&form=6&db=m Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249149&form=6&db=m Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecular mimicry phenomena? Two not mutually exclusive hypotheses. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249938&form=6&db=m The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer's Disease Pathology. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34251655&form=6&db=m COVID-19: Zinc and Angiotensin-Converting Enzyme 2 (ACE2) Deficiencies as Determinants of Risk and Severity of Disease: A Narrative Review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34252054&form=6&db=m HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34255304&form=6&db=m SARS-CoV-2 Infection and Racial Disparities in Children: Protective Mechanisms and Severe Complications Related to MIS-C. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34256245&form=6&db=m Highly expressed ACE-2 receptors during pregnancy: A protective factor for SARS-COV-2 infection? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257394&form=6&db=m Placental response to maternal SARS-CoV-2 infection. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257580&form=6&db=m Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258966&form=6&db=m Effects of Smoking on ACE2 Expression Pattern: Risk and Severity of SARS-CoV-2 Infection. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34274504&form=6&db=m Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34282416&form=6&db=m Xeno-nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34284028&form=6&db=m Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34288726&form=6&db=m Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays. ongoing research,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34293134&form=6&db=m Is SARS-CoV-2 infection a risk factor for early pregnancy loss? ACE2 and TMPRSS2 co-expression and persistent replicative infection in primitive trophoblast. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34293137&form=6&db=m Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex? diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34297554&form=6&db=m Structural Decoding of a Small Molecular Inhibitor on the Binding of SARS-CoV-2 to the ACE 2 Receptor. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34299289&form=6&db=m Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34304724&form=6&db=m A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305429&form=6&db=m Relevance Between COVID-19 and Host Genetics of Immune Response. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305888&form=6&db=m Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307408&form=6&db=m Retinal Microcirculation as a Correlate of a Systemic Capillary Impairment After Severe Acute Respiratory Syndrome Coronavirus 2 Infection. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34311326&form=6&db=m SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34321401&form=6&db=m The role of hypertension on the severity of COVID-19: a review. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34324823&form=6&db=m Optimizing testing regimes for the detection of COVID-19 in children and older adults. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34327666&form=6&db=m Is there a common pathophysiological mechanism between COVID-19 and depression? unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34328182&form=6&db=m Roles of steroid receptors in the lung and COVID-19. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34330889&form=6&db=m Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34336361&form=6&db=m A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34336866&form=6&db=m Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34340553&form=6&db=m The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341784&form=6&db=m Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34352169&form=6&db=m Health concerns regarding the effect of the COVID-19 pandemic on male fertility. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34353251&form=6&db=m The Promising Enzymes for Inhibitors Development against COVID-19. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34354803&form=6&db=m Acute mesenteric ischemia and small bowel imaging findings in COVID-19: A comprehensive review of the literature. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34358119&form=6&db=m Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34358993&form=6&db=m Identifying compounds that prevent the binding of the SARS-CoV-2 S-protein to ACE2. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360751&form=6&db=m Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360866&form=6&db=m Acute Kidney Injury in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34362133&form=6&db=m SARS-CoV-2 and Acute Cerebrovascular Events: An Overview. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34366621&form=6&db=m Gastrointestinal and hepatic diseases during the COVID-19 pandemic: Manifestations, mechanism and management. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34369278&form=6&db=m Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissues. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34371831&form=6&db=m Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats-Possible Implications for COVID-19. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34375388&form=6&db=m Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34375467&form=6&db=m Molecular dynamics analysis of a flexible loop at the binding interface of the SARS-CoV-2 spike protein receptor-binding domain. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34378968&form=6&db=m TMPRSS2 and RNA-Dependent RNA Polymerase Are Effective Targets of Therapeutic Intervention for Treatment of COVID-19 Caused by SARS-CoV-2 Variants (B.1.1.7 and B.1.351). therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34379705&form=6&db=m Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395033&form=6&db=m Coronavirus Disease 2019 Infection among Children: Pathogenesis, Treatment, and Outcome. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34398427&form=6&db=m Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403732&form=6&db=m Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34404266&form=6&db=m The Influence of Coronavirus Disease-2019 (COVID-19) On Parkinson's Disease: An Updated Systematic Review. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34404832&form=6&db=m Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406858&form=6&db=m Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407940&form=6&db=m Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34410424&form=6&db=m Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34410599&form=6&db=m PM2.5, NO2, wildfires, and other environmental exposures are linked to higher Covid 19 incidence, severity, and death rates. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34412632&form=6&db=m Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells. diagnostic usage,ongoing research,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413267&form=6&db=m The potential role of abnormal angiotensin-converting enzyme 2 expression correlated with immune infiltration after SARS-CoV-2 infection in the prognosis of breast cancer. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413390&form=6&db=m Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413500&form=6&db=m A glycan gate controls opening of the SARS-CoV-2 spike protein. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34416267&form=6&db=m Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells. diagnostic usage,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34421587&form=6&db=m The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34424815&form=6&db=m In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets Mpro and TMPRSS2. therapeutic application,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429799&form=6&db=m Ogilvie Syndrome and COVID-19 Infection. causal interaction,unassigned 1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433867&form=6&db=m Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34438017&form=6&db=m A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34440554&form=6&db=m Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34442205&form=6&db=m Oral Mucosa Could Be an Infectious Target of SARS-CoV-2. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34442770&form=6&db=m The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34444960&form=6&db=m Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445310&form=6&db=m Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445669&form=6&db=m "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34447512&form=6&db=m Renin Angiotensin Converting Enzyme 2 and COVID-19: Prevention and Treatment. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34449302&form=6&db=m Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19 Related ARDS. ongoing research,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34458283&form=6&db=m Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471088&form=6&db=m Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34474076&form=6&db=m Angiotensin-converting enzyme 2 decreased expression during kidney inflammatory diseases: implications to predisposing to COVID-19 kidney complications. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34474710&form=6&db=m Effect of COVID-19 on hereditary angioedema activity and quality of life. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34477955&form=6&db=m Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34479494&form=6&db=m The correlation between serum selenium, zinc, and COVID-19 severity: an observational study. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34480250&form=6&db=m Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. causal interaction,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483461&form=6&db=m Computational insights into binding mechanism of drugs as potential inhibitors against SARS-CoV-2 targets. therapeutic application,unassigned 4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483599&form=6&db=m Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34484179&form=6&db=m Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34490178&form=6&db=m Questionnaire Survey on the Current Situation and Experience in Prevention and Control Measures at Urology Clinics During the COVID-19 Epidemic in China. unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34494876&form=6&db=m Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34495697&form=6&db=m A bifluorescent-based assay for the identification of neutralizing antibodies against SARS-CoV-2 variants of concern in vitro and in vivo. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497535&form=6&db=m Angiotensin-Converting Enzyme 2 in the Pathogenesis of Renal Abnormalities Observed in COVID-19 Patients. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497683&form=6&db=m The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors. causal interaction,unassigned 3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34502086&form=6&db=m Enzyme Therapy: Current Challenges and Future Perspectives. ongoing research,therapeutic application,unassigned 1,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34503323&form=6&db=m Asthma and COVID-19 pandemic: focused on the eosinophil count and ACE2 expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34504360&form=6&db=m Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review. ongoing research,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34513868&form=6&db=m Pathophysiology of COVID-19: Everywhere You Look You Will See ACE2! unassigned - 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514079&form=6&db=m Identification of novel transmembrane Protease Serine Type 2 drug candidates for COVID-19 using computational studies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514615&form=6&db=m Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517212&form=6&db=m Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34541448&form=6&db=m Experimental Technologies in the Diagnosis and Treatment of COVID-19 in Patients with Comorbidities. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34543404&form=6&db=m Impact of COVID-19 on the Endocrine System - a mini-review. causal interaction,unassigned 2,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34543844&form=6&db=m Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.17.23 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34545062&form=6&db=m Human genetic basis of coronavirus disease 2019. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676577&form=6&db=m A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19. causal interaction,unassigned 2,0 3.4.17.23 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33075345&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling. unassigned - 3.4.17.23 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33156843&form=6&db=m A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. causal interaction,unassigned 2,0 3.4.17.23 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32578011&form=6&db=m Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing's syndrome. diagnostic usage,unassigned 3,0 3.4.17.23 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33401565&form=6&db=m SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.17.23 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19367833&form=6&db=m Functional characterisation of a cyst nematode acetylcholinesterase gene using Caenorhabditis elegans as a heterologous system. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19640464&form=6&db=m Functional characterisation of a cyst nematode acetylcholinesterase gene using Caenorhabditis elegans as a heterologous system. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33262177&form=6&db=m Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.17.23 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17918732&form=6&db=m An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. unassigned - 3.4.17.23 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34118974&form=6&db=m Severe COVID-19 in Alzheimer's disease: APOE4's fault again? causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33550782&form=6&db=m CNS implications of COVID-19: a comprehensive review. causal interaction,unassigned 4,0 3.4.17.23 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230886&form=6&db=m De Novo Movement Disorders and COVID-19: Exploring the Interface. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254575&form=6&db=m Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17487824&form=6&db=m Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18753062&form=6&db=m [Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142614&form=6&db=m The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992604&form=6&db=m The influence of angiotensin converting enzyme-2 gene polymorphisms: what does it predict in patients with diabetes mellitus and coronary heart disease? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31149080&form=6&db=m RELATIONSHIP OF OXIDATIVE STRESS TO URINARY ANGIOTENSIN CONVERTING ENZYME 2 IN TYPE 2 DIABETES MELLITUS PATIENTS. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31987854&form=6&db=m Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice. causal interaction,ongoing research,unassigned 3,3,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089050&form=6&db=m Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes? causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32291526&form=6&db=m Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348692&form=6&db=m COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32724306&form=6&db=m Heightened ACE Activity and Unfavorable Consequences in COVID-19 Diabetic Subjects. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080435&form=6&db=m The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33134395&form=6&db=m Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region. causal interaction,unassigned 4,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33796097&form=6&db=m Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.17.23 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34068221&form=6&db=m Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis. causal interaction,ongoing research,unassigned 2,2,0 3.4.17.23 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232095&form=6&db=m Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-?1-induced kidney injury in a mouse model of diabetes. ongoing research,unassigned 4,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15078862&form=6&db=m Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination? ongoing research,unassigned 4,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18753062&form=6&db=m [Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142614&form=6&db=m The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27312782&form=6&db=m Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28093645&form=6&db=m Erratum to: Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31149080&form=6&db=m RELATIONSHIP OF OXIDATIVE STRESS TO URINARY ANGIOTENSIN CONVERTING ENZYME 2 IN TYPE 2 DIABETES MELLITUS PATIENTS. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31987854&form=6&db=m Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice. causal interaction,ongoing research,unassigned 3,3,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089050&form=6&db=m Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes? causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33134395&form=6&db=m Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region. causal interaction,unassigned 4,0 3.4.17.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34068221&form=6&db=m Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis. causal interaction,ongoing research,unassigned 2,2,0 3.4.17.23 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24389129&form=6&db=m Angiotensin 1-7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Diabetic Ketoacidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34065123&form=6&db=m Type 1 Diabetes Mellitus in the SARS-CoV-2 Pandemic: Oxidative Stress as a Major Pathophysiological Mechanism Linked to Adverse Clinical Outcomes. causal interaction,unassigned 2,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12623933&form=6&db=m Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. ongoing research,unassigned 3,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408475&form=6&db=m New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18454253&form=6&db=m Advances in the renin-angiotensin-aldosterone system: relevance to diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20844835&form=6&db=m Angiotensin-Converting Enzyme 2 Overexpression Remarkably Ameliorated Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition. therapeutic application,unassigned 2,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22113528&form=6&db=m Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22475818&form=6&db=m Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice. ongoing research,unassigned 3,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893398&form=6&db=m Assessment of diabetic nephropathy in the akita mouse. causal interaction,unassigned 3,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24297485&form=6&db=m Olmesartan Blocks Advanced Glycation End Products-induced VCAM-1 Gene Expression in Mesangial Cells by Restoring Angiotensin-converting Enzyme 2 Level. therapeutic application,unassigned 4,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24553436&form=6&db=m Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation and lipotoxicity. unassigned - 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25287898&form=6&db=m Urinary angiotensin-converting enzyme 2 increases in diabetic nephropathy by angiotensin II type 1 receptor blocker olmesartan. therapeutic application,unassigned 1,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25791940&form=6&db=m Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815490&form=6&db=m [Association between angiotensin-converting enzyme 2 gene polymorphisms and childhood primary nephrotic syndrome]. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27379538&form=6&db=m Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27927599&form=6&db=m Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy. therapeutic application,unassigned 2,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28501298&form=6&db=m ACE2 as therapy for glomerular disease: the devil is in the detail. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591810&form=6&db=m A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32109518&form=6&db=m Mesenchymal stem cells modified with angiotensin-converting enzyme 2 are superior for amelioration of glomerular fibrosis in diabetic nephropathy. therapeutic application,unassigned 1,0 3.4.17.23 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917504&form=6&db=m Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.17.23 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29761600&form=6&db=m Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction. unassigned - 3.4.17.23 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9325052&form=6&db=m Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. unassigned - 3.4.17.23 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32987060&form=6&db=m Mechanisms and treatments of myocardial injury in patients with corona virus disease 2019. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Dysgeusia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32888876&form=6&db=m Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? causal interaction,unassigned 4,0 3.4.17.23 Dysgeusia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34420001&form=6&db=m The Impact of COVID-19 in Gastroenterology and Hepatology. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Dyspnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30028971&form=6&db=m Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.17.23 Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20933203&form=6&db=m Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). causal interaction,unassigned 4,0 3.4.17.23 Embolic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34111949&form=6&db=m Angiotensin-Converting Enzyme 2 Activity Is Associated With Embolic Stroke of Undetermined Source. unassigned - 3.4.17.23 Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33499680&form=6&db=m Obesity considerations during the COVID-19 outbreak. causal interaction,unassigned 4,0 3.4.17.23 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230886&form=6&db=m De Novo Movement Disorders and COVID-19: Exploring the Interface. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19059488&form=6&db=m Resolving genetic diversity in Australasian Culex mosquitoes: incongruence between the mitochondrial cytochrome c oxidase I and nuclear acetylcholine esterase 2. unassigned - 3.4.17.23 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584199&form=6&db=m Human and novel coronavirus infections in children: a review. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468052&form=6&db=m Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Enterocolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33436481&form=6&db=m Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Eosinophilic Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33394891&form=6&db=m Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders. ongoing research,unassigned 4,0 3.4.17.23 Epistaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34189359&form=6&db=m Severe Epistaxis after Tissue Plasminogen Activator administration for Acute Ischemic Stroke in SARS-COV-2 Infection. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15233982&form=6&db=m No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16866021&form=6&db=m Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17024138&form=6&db=m Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese. causal interaction,unassigned 3,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20117991&form=6&db=m [Relationship of angiotensin-converting enzyme 2 gene polymorphism with the prognosis of hypertensive stroke patients] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813695&form=6&db=m [Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke.] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20933203&form=6&db=m Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). causal interaction,unassigned 4,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22297693&form=6&db=m ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22988445&form=6&db=m Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects. causal interaction,unassigned 4,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24112034&form=6&db=m Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha, India. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25237167&form=6&db=m The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28895159&form=6&db=m Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites. causal interaction,unassigned 4,0 3.4.17.23 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30335025&form=6&db=m Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: A case-control study. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Exocrine Pancreatic Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33401565&form=6&db=m SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.17.23 Eye Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085038&form=6&db=m EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases. causal interaction,unassigned 3,0 3.4.17.23 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24114819&form=6&db=m Pioglitazone upregulates hepatic angiotensin converting enzyme 2 expression in rats with steatohepatitis. ongoing research,unassigned 1,0 3.4.17.23 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25887687&form=6&db=m Impact of hepatic immunoreactivity of angiotensin-converting enzyme 2 on liver fibrosis due to non-alcoholic steatohepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21968754&form=6&db=m Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. unassigned - 3.4.17.23 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28842425&form=6&db=m Photoacoustic imaging for in vivo quantification of placental oxygenation in mice. unassigned - 3.4.17.23 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663464&form=6&db=m Loss of angiotensin-converting enzyme 2 promotes growth of gallbladder cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 3.4.17.23 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33394891&form=6&db=m Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders. ongoing research,unassigned 4,0 3.4.17.23 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33707526&form=6&db=m Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.17.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33051304&form=6&db=m Similarities in Risk for COVID-19 and Cancer Disparities. causal interaction,unassigned 4,0 3.4.17.23 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23702784&form=6&db=m Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2. ongoing research,unassigned 4,0 3.4.17.23 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26204514&form=6&db=m Ocular Inserts for Sustained Release of the Angiotensin-Converting Enzyme 2 Activator, Diminazene Aceturate, to Treat Glaucoma in Rats. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32756783&form=6&db=m Aqueous humor renin, angiotensin I, and angiotensin II activity in primary open-angle glaucoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.17.23 Glomerulonephritis, IGA http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24158104&form=6&db=m Glomerular angiotensin-converting enzyme 2 in pediatric IgA nephropathy. therapeutic application,unassigned 3,0 3.4.17.23 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19333547&form=6&db=m Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23671869&form=6&db=m Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967703&form=6&db=m TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.17.23 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542974&form=6&db=m Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Heart Defects, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548773&form=6&db=m The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Heart Defects, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33280062&form=6&db=m Determinants of soluble angiotensin-converting enzyme 2 concentrations in adult patients with complex congenital heart disease. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.4.17.23 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31254308&form=6&db=m Plasma and tissue angiotensin-converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32739642&form=6&db=m Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment. therapeutic application,unassigned 1,0 3.4.17.23 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32789839&form=6&db=m Cardiovascular disease during the COVID-19 pandemic: Think ahead, protect hearts, reduce mortality. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33135833&form=6&db=m Effect of angiotensin receptor blockers and angiotensin-converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in cats with heart disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.17.23 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421274&form=6&db=m Circulating cardiovascular microRNAs in critically ill COVID-19 patients. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33426593&form=6&db=m Challenge of post-COVID era: management of cardiovascular complications in asymptomatic carriers of SARS-CoV-2. causal interaction,unassigned 4,0 3.4.17.23 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177593&form=6&db=m A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency. causal interaction,unassigned 3,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16179584&form=6&db=m Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients. unassigned - 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16261211&form=6&db=m [Cloning of ACE-2 gene encoding the functional receptor for the SARS coronavirus and its expression in eukaryotic cells] diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718423&form=6&db=m Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19700132&form=6&db=m Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20060185&form=6&db=m Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure. causal interaction,therapeutic application,unassigned 2,2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21611889&form=6&db=m Recombinant human Angiotensin-converting enzyme 2 as a new Renin-Angiotensin system peptidase for heart failure therapy. ongoing research,therapeutic application,unassigned 3,4,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21963832&form=6&db=m Angiotensin-converting enzyme 2 overexpression improves central nitric oxide-mediated sympathetic outflow in chronic heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025374&form=6&db=m Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure. causal interaction,unassigned 2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22381157&form=6&db=m N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery. diagnostic usage,unassigned 2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151079&form=6&db=m Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems. therapeutic application,unassigned 2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23176220&form=6&db=m Angiotensin (1-7) and other angiotensin peptide. causal interaction,ongoing research,unassigned 2,3,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24054336&form=6&db=m Increasing serum soluble Angiotensin-converting enzyme 2 activity after intensive medical therapy is associated with better prognosis in acute decompensated heart failure. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24161906&form=6&db=m Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway. causal interaction,unassigned 2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24293035&form=6&db=m Angiotensin-converting enzyme 2 as a therapeutic target for heart failure. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24691269&form=6&db=m New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure. unassigned - 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25164432&form=6&db=m Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via G?q-mediated mechanism. causal interaction,unassigned 3,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25217176&form=6&db=m Cardiac and renal distribution of ACE and ACE-2 in rats with heart failure. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25869724&form=6&db=m Balance between angiotensin converting enzyme and angiotensin converting enzyme 2 in patients with chronic heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412778&form=6&db=m Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27421979&form=6&db=m Serum angiotensin-converting enzyme 2 concentration and angiotensin-(1-7) concentration in patients with acute heart failure patients requiring emergency hospitalization. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29100503&form=6&db=m Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29490639&form=6&db=m Commenting on "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues. ongoing research,unassigned 2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29733687&form=6&db=m Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study. diagnostic usage,unassigned 3,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30124209&form=6&db=m [Role of ACE2-Ang (1-7)-Mas receptor axis in heart failure with preserved ejection fraction with hypertension]. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31323221&form=6&db=m Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32362932&form=6&db=m Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure. therapeutic application,unassigned 2,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388547&form=6&db=m Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388565&form=6&db=m Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32458985&form=6&db=m The serum angiotensin-converting enzyme 2 and angiotensin-(1-7) concentrations after optimal therapy for acute decompensated heart failure with reduced ejection fraction. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32616194&form=6&db=m Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844337&form=6&db=m Angiotensin-converting enzyme 2: a double-edged sword in COVID-19 patients with an increased risk of heart failure. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953401&form=6&db=m The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245872&form=6&db=m High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study. diagnostic usage,unassigned 1,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33539861&form=6&db=m Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660945&form=6&db=m Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.17.23 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33986851&form=6&db=m Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of ACE2 and MCP-1 polymorphisms with echocardiography parameters: A comparative study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Heart Failure, Systolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19700132&form=6&db=m Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.17.23 Heart Failure, Systolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31323221&form=6&db=m Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Hemangioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33861415&form=6&db=m ?-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.17.23 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32333199&form=6&db=m Coronavirus in Hematologic Malignancies: Targeting Molecules Beyond the Angiotensin-Converting Enzyme 2 (ACE2) Wall in COVID-19. unassigned - 3.4.17.23 Hematuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080435&form=6&db=m The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Hemorrhagic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32527987&form=6&db=m Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Hemorrhagic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33192492&form=6&db=m COVID-19-Related Intracerebral Hemorrhage. causal interaction,unassigned 4,0 3.4.17.23 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33153403&form=6&db=m Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection? causal interaction,unassigned 1,0 3.4.17.23 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34455696&form=6&db=m A decoy strategy to activate the immune system. unassigned - 3.4.17.23 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553448&form=6&db=m The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25203900&form=6&db=m Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.17.23 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33790352&form=6&db=m Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by Grazoprevir. therapeutic application,unassigned 4,0 3.4.17.23 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33488517&form=6&db=m The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34252054&form=6&db=m HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 Hyperaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33657582&form=6&db=m Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25734995&form=6&db=m TMPRSS2, a novel membrane-anchored mediator in cancer pain. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3 3.4.17.23 Hyperandrogenism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33351362&form=6&db=m [Androgens and Antiandrogens influence on COVID-19 disease in men]. causal interaction,unassigned 3,0 3.4.17.23 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32570882&form=6&db=m Cholesterol in Relation to COVID-19: Should We Care about It? causal interaction,unassigned 4,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15078862&form=6&db=m Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination? ongoing research,unassigned 4,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26421871&form=6&db=m Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina. causal interaction,unassigned 2,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32613777&form=6&db=m Coronavirus Disease 2019 and Diabetes: The Epidemic and the Korean Diabetes Association Perspective. therapeutic application,unassigned 2,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32671936&form=6&db=m Factors leading to high morbidity and mortality of COVID-19 in patients with type 2 diabetes. causal interaction,unassigned 4,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33312199&form=6&db=m Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways. causal interaction,unassigned 4,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33395782&form=6&db=m New onset diabetes, type 1 diabetes and COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34124187&form=6&db=m COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33242628&form=6&db=m COVID-19 Susceptibility in Bronchial Asthma. causal interaction,unassigned 4,0 3.4.17.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33598195&form=6&db=m Alternative antibiotic feed additives alleviate pneumonia with inhibiting ACE-2 expression in the respiratory system of piglets. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075344&form=6&db=m Angiotensin-converting enzyme 2 is an essential regulator of heart function. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15233982&form=6&db=m No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15640278&form=6&db=m Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203874&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. ongoing research,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16459167&form=6&db=m Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952638&form=6&db=m Nicotine modulates the Renin-Angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of wistar kyoto and spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18022600&form=6&db=m Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese. therapeutic application,unassigned 1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18296494&form=6&db=m Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17beta-oestradiol regulation of renal pathology in renal wrap hypertension in rats. ongoing research,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367030&form=6&db=m Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408475&form=6&db=m New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18419956&form=6&db=m [An experimental study of expression of angiotension converting enzyme 2 in myocardium and effect of telmisartan treatment in pressure-overloaded rats] ongoing research,therapeutic application,unassigned 4,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18809792&form=6&db=m Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function. ongoing research,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926157&form=6&db=m Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047579&form=6&db=m Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. ongoing research,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19065898&form=6&db=m [Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats] ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19593210&form=6&db=m Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19923158&form=6&db=m Angiotensin-converting enzyme 2: a new target for neurogenic hypertension. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19926873&form=6&db=m Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19948988&form=6&db=m Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. ongoing research,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21881224&form=6&db=m Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 are involved in sinoaortic denervation-induced cardiovascular hypertrophy in rats. unassigned - 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460555&form=6&db=m Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613639&form=6&db=m Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22777933&form=6&db=m Murine Recombinant Angiotensin-Converting Enzyme 2: Effect on Angiotensin II-Dependent Hypertension and Distinctive Angiotensin-Converting Enzyme 2 Inhibitor Characteristics on Rodent and Human Angiotensin-Converting Enzyme 2. ongoing research,therapeutic application,unassigned 4,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23095677&form=6&db=m Propofol increases angiotensin-converting enzyme 2 expression in human pulmonary artery endothelial cells. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151079&form=6&db=m Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems. therapeutic application,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548773&form=6&db=m The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23652350&form=6&db=m ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24014829&form=6&db=m Brain ACE2 Shedding Contributes to the Development of Neurogenic Hypertension. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24048198&form=6&db=m Loss of Collectrin, an ACE2 Homologue, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction. unassigned - 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24048199&form=6&db=m Collectrin, an X-Linked, ACE2 Homologue Causes Hypertension in a Rat Strain through Gene-Gene and Gene-Environment Interactions: Relevance to Human Hypertension. unassigned - 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24342297&form=6&db=m Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24510672&form=6&db=m ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24691269&form=6&db=m New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure. unassigned - 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24838502&form=6&db=m Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats. causal interaction,unassigned 3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25405471&form=6&db=m Chronic sleep restriction during pregnancy--repercussion on cardiovascular and renal functioning of male offspring. causal interaction,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25489058&form=6&db=m Brain-targeted Angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25495544&form=6&db=m Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25519733&form=6&db=m Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815490&form=6&db=m [Association between angiotensin-converting enzyme 2 gene polymorphisms and childhood primary nephrotic syndrome]. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25971747&form=6&db=m Antenatal maternal low protein diet: ACE-2 in the mouse lung and sexually dimorphic programming of hypertension. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26078188&form=6&db=m Administration of 17?-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism. causal interaction,unassigned 3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27219044&form=6&db=m Multiple faces of fibroblast growth factor-23. causal interaction,unassigned 1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423630&form=6&db=m Insufficient hypothalamic angiotensin-converting enzyme 2 is associated with hypertension in SHR rats. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28500596&form=6&db=m Measuring Blood Pressure Using a Noninvasive Tail Cuff Method in Mice. unassigned - 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28512108&form=6&db=m Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29146157&form=6&db=m Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29706566&form=6&db=m FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29903860&form=6&db=m A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30124209&form=6&db=m [Role of ACE2-Ang (1-7)-Mas receptor axis in heart failure with preserved ejection fraction with hypertension]. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30318562&form=6&db=m Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats. causal interaction,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30806090&form=6&db=m Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30956259&form=6&db=m Effect of Prolonged Infusion of Alamandine on Cardiovascular Parameters and Cardiac ACE2 Expression in a Rat Model of Renovascular Hypertension. ongoing research,unassigned 4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32214680&form=6&db=m Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function. causal interaction,unassigned 1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32214681&form=6&db=m Angiotensin Converting Enzyme-2 (ACE2) and its Possible Roles in Hypertension, Diabetes and Cardiac Function. causal interaction,unassigned 1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32241831&form=6&db=m Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32291526&form=6&db=m Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450334&form=6&db=m The interplay of hypertension, ACE-2 and SARS-CoV-2: Emerging data as the "Ariadne's thread" for the "labyrinth" of COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32721806&form=6&db=m Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS). causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32748331&form=6&db=m Physiological Relevance of Angiotensin Converting Enzyme 2 As a Metabolic Linker and Therapeutic Implication of Mesenchymal Stem Cells in COVID-19 and Hypertension. therapeutic application,unassigned 1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755395&form=6&db=m MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835160&form=6&db=m The interaction between the endocannabinoid system and the renin angiotensin system and its potential implication for COVID-19 infection. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953401&form=6&db=m The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33206176&form=6&db=m Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254553&form=6&db=m A role of glycation and methylation for SARS-CoV-2 infection in diabetes? causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308506&form=6&db=m Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33329052&form=6&db=m Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33447763&form=6&db=m Cardiovascular medications and regulation of COVID-19 receptors expression. causal interaction,unassigned 3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469197&form=6&db=m Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33513487&form=6&db=m Prediction of death status on the course of treatment in SARS-COV-2 patients with deep learning and machine learning methods. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33539861&form=6&db=m Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33563197&form=6&db=m The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33750913&form=6&db=m Overexpression of angiotensin-converting enzyme 2 by renin-angiotensin system inhibitors. Truth or myth? A systematic review of animal studies. therapeutic application,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806709&form=6&db=m Clinical Management of Hypertension, Inflammation and Thrombosis in Hospitalized COVID-19 Patients: Impact on Survival and Concerns. therapeutic application,unassigned 4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33998404&form=6&db=m [Cardiac Involvement in COVID-19]. causal interaction,unassigned 4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073591&form=6&db=m Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177593&form=6&db=m A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency. causal interaction,unassigned 3,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34183961&form=6&db=m In Silico Comparison of Separate or Combinatorial Effects of Potential Inhibitors of the SARS-CoV-2 Binding Site of ACE2. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34321401&form=6&db=m The role of hypertension on the severity of COVID-19: a review. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34349662&form=6&db=m Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat. ongoing research,unassigned 2,0 3.4.17.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34504610&form=6&db=m Angiotensin-converting enzyme 2 alleviates pulmonary artery hypertension through inhibition of focal adhesion kinase expression. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30934723&form=6&db=m Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19246717&form=6&db=m Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19564552&form=6&db=m Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851091&form=6&db=m Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370913&form=6&db=m Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23504361&form=6&db=m Angiotensin-converting enzyme 2 activation for treatment of pulmonary hypertension. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548773&form=6&db=m The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225206&form=6&db=m Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30628484&form=6&db=m MiRNA let-7b promotes the development of hypoxic pulmonary hypertension by targeting ACE2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681251&form=6&db=m Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30950337&form=6&db=m Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.4.17.23 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26715125&form=6&db=m Cardiac ACE2/angiotensin 1-7/Mas receptor axis is activated in thyroid hormone-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16283142&form=6&db=m Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men Results of the MONICA Augsburg echocardiographic substudy. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18208662&form=6&db=m Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy. causal interaction,unassigned 3,0 3.4.17.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18560893&form=6&db=m Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy. causal interaction,unassigned 3,0 3.4.17.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926157&form=6&db=m Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24342297&form=6&db=m Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27219044&form=6&db=m Multiple faces of fibroblast growth factor-23. causal interaction,unassigned 1,0 3.4.17.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30917908&form=6&db=m Hypertension and hypertensive left ventricular hypertrophy are associated with ACE2 genetic polymorphism. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Hypoalbuminemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142989&form=6&db=m Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 Hypoalbuminemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33680692&form=6&db=m Clinical features resembling subcutaneous insulin resistance observed in a patient with type 2 diabetes and severe COVID-19-associated pneumonia: a case report. unassigned - 3.4.17.23 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471195&form=6&db=m A virus-free cellular model recapitulates several features of severe COVID-19. ongoing research,unassigned 3,0 3.4.17.23 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32525548&form=6&db=m Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.17.23 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142989&form=6&db=m Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31424249&form=6&db=m Intradialytic hypotension: beyond hemodynamics. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.17.23 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23100504&form=6&db=m Cell cycle-dependence of ACE-2 explains downregulation in Idiopathic pulmonary fibrosis. unassigned - 3.4.17.23 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973879&form=6&db=m Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.17.23 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112187&form=6&db=m Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706759&form=6&db=m Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194496&form=6&db=m Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15258961&form=6&db=m Persistent infection of SARS coronavirus in colonic cells in vitro. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15356152&form=6&db=m Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645376&form=6&db=m Susceptibility of different eukaryotic cell lines to SARS-coronavirus. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16306622&form=6&db=m Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. therapeutic application,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337697&form=6&db=m Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16690935&form=6&db=m Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079315&form=6&db=m Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392154&form=6&db=m Pathology and pathogenesis of severe acute respiratory syndrome. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974127&form=6&db=m Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448527&form=6&db=m Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587105&form=6&db=m Pathology of experimental SARS coronavirus infection in cats and ferrets. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18931070&form=6&db=m Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19158246&form=6&db=m Proteolytic activation of the 1918 influenza virus hemagglutinin. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19297479&form=6&db=m Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110095&form=6&db=m Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20926566&form=6&db=m Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21994442&form=6&db=m Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22222211&form=6&db=m Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22496216&form=6&db=m Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22787216&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22865222&form=6&db=m Characterisation of animal angiotensin-converting enzyme 2 receptors and use of pseudotyped virus to correlate receptor binding with susceptibility of SARS-CoV infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23468491&form=6&db=m The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536651&form=6&db=m TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23572553&form=6&db=m The emergence of human coronavirus EMC: how scared should we be? unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24023659&form=6&db=m Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24027332&form=6&db=m Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Mediated by the Transmembrane Serine Protease TMPRSS2. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24348248&form=6&db=m Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24600012&form=6&db=m The host protease TMPRSS2 plays a major role for in vivo replication of emerging H7N9 and seasonal influenza viruses. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24800825&form=6&db=m Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25187545&form=6&db=m Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25203900&form=6&db=m Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26487711&form=6&db=m Reconstitution of the receptor-binding motif of the SARS coronavirus. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26889029&form=6&db=m The proteolytic activation of A (H3N2) Influenza virus hemagglutinin is facilitated by different type II transmembrane serine proteases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277342&form=6&db=m In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28148786&form=6&db=m Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759649&form=6&db=m The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30626688&form=6&db=m TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32200663&form=6&db=m COVID-19 and Cardiovascular Disease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215613&form=6&db=m Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267499&form=6&db=m The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276929&form=6&db=m TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32290680&form=6&db=m Severe acute respiratory syndrome coronavirus 2 infection, angiotensin-converting enzyme 2 and treatment with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32298273&form=6&db=m The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32299779&form=6&db=m What Is the Role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 Infection in Hypertensive Patients With Diabetes? causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32305401&form=6&db=m Clinical Implications of SARS-CoV-2 Interaction With Renin Angiotensin System: JACC Review Topic of the Week. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32316719&form=6&db=m [A special on epidemic prevention and control: analysis on expression of 2019-nCoV related ACE2 and TMPRSS2 in eye tissues]. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,1 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321537&form=6&db=m H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32333836&form=6&db=m Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32335209&form=6&db=m Correspondence: Angiotensin-converting enzyme 2 coated nanoparticles containing respiratory masks, chewing gums and nasal filters may be used for protection against COVID-19 infection. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364011&form=6&db=m FDA-approved thiol-reacting drugs that potentially bind into the SARS-CoV-2 main protease, essential for viral replication. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32406140&form=6&db=m The ocular surface, coronaviruses and COVID-19. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32423095&form=6&db=m The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32446267&form=6&db=m What solid organ transplant healthcare providers should know about renin-angiotensin-aldosterone system inhibitors and COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32448098&form=6&db=m Structural and simulation analysis of hotspot residues interactions of SARS-CoV 2 with human ACE2 receptor. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32452644&form=6&db=m Caution in the management of SARS-CoV-2 infection in males. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32453494&form=6&db=m SARS-CoV-2 presence in seminal fluid: Myth or reality. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32464637&form=6&db=m The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin-angiotensin system. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32479133&form=6&db=m TMPRSS2 and ACE2 Coexpression in SARS-CoV-2 Salivary Glands Infection. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485164&form=6&db=m A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32488318&form=6&db=m Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32501427&form=6&db=m Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32502616&form=6&db=m Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32516571&form=6&db=m Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32527987&form=6&db=m Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32529643&form=6&db=m Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540737&form=6&db=m Use of pioglitazone in people with type 2 diabetes mellitus with coronavirus disease 2019 (COVID-19): Boon or bane? causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32545271&form=6&db=m Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32572552&form=6&db=m [What is the importance of the conjunctiva as a potential transmission pathway for SARS-CoV-2 infections?] causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577647&form=6&db=m Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32578011&form=6&db=m Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing's syndrome. diagnostic usage,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32578794&form=6&db=m Sars-CoV-2: A clinical update - II. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32582302&form=6&db=m Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32583042&form=6&db=m [Can SARS-CoV-2 infect the eye?-An overview of the receptor status in ocular tissue]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32583639&form=6&db=m [RISK ASSESSMENT FOR AEROSOL INFECTION BY THE NEW CORONA VIRUS AND PROTECTION BY RESPIRATORS]. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32593613&form=6&db=m Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32596694&form=6&db=m An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32597377&form=6&db=m The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,3 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32602627&form=6&db=m Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32622449&form=6&db=m Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32624690&form=6&db=m Cardiovascular disease management during the coronavirus disease 2019 pandemic. diagnostic usage,therapeutic application,unassigned 2,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32635289&form=6&db=m ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32637954&form=6&db=m Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32639866&form=6&db=m Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652140&form=6&db=m Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32657473&form=6&db=m TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32660065&form=6&db=m COVID-19, Renin-Angiotensin System and Endothelial Dysfunction. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32661206&form=6&db=m Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32665962&form=6&db=m The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32670592&form=6&db=m Mild SARS-CoV-2 infections in children might be based on evolutionary biology and linked with host reactive oxidative stress and antioxidant capabilities. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675206&form=6&db=m Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675312&form=6&db=m ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676592&form=6&db=m Which animals are at risk? Predicting species susceptibility to Covid-19. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679185&form=6&db=m Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32683039&form=6&db=m ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685221&form=6&db=m Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32693711&form=6&db=m Coronavirus Disease 2019: Coronaviruses and Kidney Injury. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705281&form=6&db=m Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714125&form=6&db=m Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32719799&form=6&db=m Current Findings Regarding Natural Components With Potential Anti-2019-nCoV Activity. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726325&form=6&db=m Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726802&form=6&db=m A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32733785&form=6&db=m Characterization of changes in global gene expression in the hearts and kidneys of transgenic mice overexpressing human angiotensin-converting enzyme 2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32743574&form=6&db=m Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32750108&form=6&db=m Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32750141&form=6&db=m Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32750256&form=6&db=m Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32753553&form=6&db=m Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32788194&form=6&db=m Optimized pseudotyping conditions for the SARS COV-2 Spike glycoprotein. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793909&form=6&db=m mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802318&form=6&db=m Potential chimeric peptides to block the SARS-CoV-2 spike receptor-binding domain. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32803197&form=6&db=m Opposing activities of IFITM proteins in SARS-CoV-2 infection. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32810867&form=6&db=m The Cellular basis of the loss of smell in 2019-nCoV-infected individuals. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32829257&form=6&db=m Viral, host and environmental factors that favor anthropozoonotic spillover of coronaviruses: An opinionated review, focusing on SARS-CoV, MERS-CoV and SARS-CoV-2. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32831326&form=6&db=m The big challenge of SARS-CoV-2 latency: testes as reservoir. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32839779&form=6&db=m Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity. therapeutic application,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850973&form=6&db=m A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment. therapeutic application,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32851697&form=6&db=m Single-cell RNA expression profiling of ACE2 and TMPRSS2 in the human trophectoderm and placenta. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32853537&form=6&db=m Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32857620&form=6&db=m Azithromycin Downregulates Gene Expression of IL-1? and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32861856&form=6&db=m Age-Related Differences in Immunological Responses to SARS-CoV-2. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863157&form=6&db=m Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32864982&form=6&db=m Interaction Between Coronavirus S-Protein and Human ACE2: Hints for Exploring Efficient Therapeutic Targets to Treat COVID-19. causal interaction,ongoing research,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32886791&form=6&db=m Site-specific characterisation of SARS-CoV-2 spike glycoprotein receptor binding domain. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32891636&form=6&db=m MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32897764&form=6&db=m Androgen Deprivation Therapy in Men With Prostate Cancer Does Not Affect Risk of Infection With SARS-CoV-2. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32900008&form=6&db=m COVID-19 and Kidney Injury. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32902940&form=6&db=m Severe acute respiratory syndrome coronavirus-2 and the deduction effect of angiotensin-converting enzyme 2 in pregnancy. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32905655&form=6&db=m Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32914945&form=6&db=m Angiotensin Converting Enzyme-2 (ACE2) receptors, asthma and severe COVID-19 infection risk. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917504&form=6&db=m Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936429&form=6&db=m Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32940201&form=6&db=m Extrapulmonary Clinical Manifestations in COVID-19 Patients. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32940922&form=6&db=m Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats: implications on COVID 19 infections. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953947&form=6&db=m SARS-CoV-2 infection: physiological and environmental gift factors at high altitude. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32966582&form=6&db=m SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968798&form=6&db=m Unveiling COVID-19-associated organ-specific cell types and cell-specific pathway cascade. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32972339&form=6&db=m Targeting host cell proteases to prevent SARS-CoV-2 invasion. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973879&form=6&db=m Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32974373&form=6&db=m Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32975865&form=6&db=m Expression of ACE2 in airways: implication for COVID-19 risk and disease management in patients with chronic inflammatory respiratory diseases. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982622&form=6&db=m Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32984892&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991251&form=6&db=m The COVID-19 Pandemic: A Global Health Crisis. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995789&form=6&db=m Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015868&form=6&db=m Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33036546&form=6&db=m Role of angiotensin-converting enzyme 2 and pericytes in cardiac complications of COVID-19 infection. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33039120&form=6&db=m [Association of hypertension and antihypertensive agents and the severity of COVID-19 pneumonia. A monocentric French prospective study]. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33042151&form=6&db=m Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043050&form=6&db=m Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059811&form=6&db=m [Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065601&form=6&db=m Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33073064&form=6&db=m Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33084449&form=6&db=m Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33090532&form=6&db=m Susceptibility of livestock and companion animals to COVID-19. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33097184&form=6&db=m Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33104520&form=6&db=m Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33106802&form=6&db=m Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33109794&form=6&db=m Covid 19 and its cardiovascular effects. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112126&form=6&db=m Targeting Crucial Host Factors of SARS-CoV-2. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33125431&form=6&db=m Kidney ACE2 expression: Implications for chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33130103&form=6&db=m The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33137894&form=6&db=m Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33138699&form=6&db=m Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection: in silico approaches. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33141332&form=6&db=m What is the significance of the conjunctiva as a potential transmission route for SARS-CoV-2 infections? causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142828&form=6&db=m Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33148439&form=6&db=m Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159417&form=6&db=m Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33164230&form=6&db=m Insights into disparities observed with COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33172369&form=6&db=m In-silico analysis of angiotensin converting enzyme 2 (ACE2) of livestock, pet and poultry animals to determine its susceptibility to SARS-CoV- 2 infection. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33173878&form=6&db=m SARS-CoV-2 Innate Effector Associations and Viral Load in Early Nasopharyngeal Infection. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176395&form=6&db=m Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33177848&form=6&db=m Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178900&form=6&db=m SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33184236&form=6&db=m SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. causal interaction,ongoing research,unassigned 2,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186231&form=6&db=m Structural basis of severe acute respiratory syndrome coronavirus 2 infection. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193639&form=6&db=m Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193689&form=6&db=m TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195397&form=6&db=m Drug Weaponry to Fight Against SARS-CoV-2. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197204&form=6&db=m COVID-19-Associated Nonocclusive Fibrin Microthrombi in the Heart. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33199671&form=6&db=m Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33206164&form=6&db=m ACE-2 Downregulation and Incidence of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Infection. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33208074&form=6&db=m Inhibition of S-protein RBD and hACE2 Interaction for Control of SARSCoV- 2 Infection (COVID-19). therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33232663&form=6&db=m Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239166&form=6&db=m Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33244671&form=6&db=m A Case-Control Study of the 2019 Influenza Vaccine and Incidence of COVID-19 Among Healthcare Workers. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245471&form=6&db=m Expression and co-expression analyses of TMPRSS2, a key element in COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33249290&form=6&db=m A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33250972&form=6&db=m SARS-CoV2 infectivity is potentially modulated by host redox status. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254494&form=6&db=m Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254543&form=6&db=m Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33263566&form=6&db=m Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33269352&form=6&db=m A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33270927&form=6&db=m Opposing activities of IFITM proteins in SARS-CoV-2 infection. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278516&form=6&db=m ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,3 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281941&form=6&db=m The gut microbiome: an under-recognised contributor to the COVID-19 pandemic? causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289868&form=6&db=m Can SARS-CoV-2 infect the eye? An overview of the receptor status in ocular tissue. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33291720&form=6&db=m The Benefits of Vitamin D Supplementation for Athletes: Better Performance and Reduced Risk of COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33296619&form=6&db=m Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33301988&form=6&db=m Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310780&form=6&db=m Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33315853&form=6&db=m Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33326500&form=6&db=m mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33326798&form=6&db=m An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2. therapeutic application,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33328008&form=6&db=m [A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019]. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33344912&form=6&db=m Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33345626&form=6&db=m The cardiovascular aspect of COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33359190&form=6&db=m Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363207&form=6&db=m Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33380375&form=6&db=m Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19? causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33398271&form=6&db=m Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33405941&form=6&db=m Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33407110&form=6&db=m Rapid single cell evaluation of human disease and disorder targets using REVEAL: SingleCell™. causal interaction,ongoing research,unassigned 2,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33412255&form=6&db=m Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417604&form=6&db=m Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2). causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33423311&form=6&db=m Human SARS CoV-2 spike protein mutations. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33435547&form=6&db=m The Effects of COVID-19 on Placenta and Pregnancy: What Do We Know So Far? unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33435929&form=6&db=m Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33436481&form=6&db=m Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33437137&form=6&db=m Combination and tricombination therapy to destabilize the structural integrity of COVID-19 by some bioactive compounds with antiviral drugs: insights from molecular docking study. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441348&form=6&db=m Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33442693&form=6&db=m MVA Vector Vaccines Inhibit SARS CoV-2 Replication in Upper and Lower Respiratory Tracts of Transgenic Mice and Prevent Lethal Disease. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33462543&form=6&db=m Role of indoor aerosols for COVID-19 viral transmission: a review. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469197&form=6&db=m Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469570&form=6&db=m Small Molecules to Destabilize the ACE2-RBD Complex: A Molecular Dynamics Study for Potential COVID-19 Therapeutics. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469649&form=6&db=m Exploring G protein-coupled receptors and yeast surface display strategies for viral detection in baker's yeast: SARS-CoV-2 as a case study. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470888&form=6&db=m Distribution of the ACE1 D Allele in the Bosnian-Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33472206&form=6&db=m Ocular pathology and occasionally detectable intraocular SARS-CoV-2 RNA in five fatal COVID-19 cases. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484868&form=6&db=m Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33502950&form=6&db=m Soluble ACE2 as a potential therapy for COVID-19. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33507952&form=6&db=m Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33521016&form=6&db=m Susceptibility Factors of Stomach for SARS-CoV-2 and Treatment Implication of Mucosal Protective Agent in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33521783&form=6&db=m Stroke in patients infected by the novel coronavirus and its causal mechanisms: A narrative review. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525682&form=6&db=m Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33526471&form=6&db=m A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537060&form=6&db=m The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33547593&form=6&db=m Murine-?-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33558851&form=6&db=m SUMO pathway, blood coagulation and oxidative stress in SARS-CoV-2 infection. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33563197&form=6&db=m The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33571742&form=6&db=m COVID-19 and developmental origins of health and disease. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33585826&form=6&db=m Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes. diagnostic usage,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33595856&form=6&db=m Genetic variation analyses indicate conserved SARS-CoV-2-host interaction and varied genetic adaptation in immune response factors in modern human evolution. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611416&form=6&db=m Severe acute respiratory syndrome coronavirus 2 infection, angiotensin-converting enzyme 2 and treatment with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33613576&form=6&db=m An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19? unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614688&form=6&db=m Decreased Mortality Rate Among COVID-19 Patients Prescribed Statins: Data From Electronic Health Records in the US. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619331&form=6&db=m Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619488&form=6&db=m Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619758&form=6&db=m Tetracycline as an inhibitor to the SARS-CoV-2. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33621484&form=6&db=m Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33625796&form=6&db=m SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33651072&form=6&db=m Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33655239&form=6&db=m Expression of SARS-CoV-2-related Receptors in Cells of the Neurovascular Unit: Implications for HIV-1 Infection. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660398&form=6&db=m Dual role for angiotensin-converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33662873&form=6&db=m The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33666220&form=6&db=m Type-2 diabetes, a co-morbidity in Covid-19: does insulin signaling matter? ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33667455&form=6&db=m Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33668523&form=6&db=m Bioactive Alkaloids from Genus Aspergillus: Mechanistic Interpretation of Their Antimicrobial and Potential SARS-CoV-2 Inhibitory Activity Using Molecular Modelling. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33683787&form=6&db=m A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism*. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684975&form=6&db=m A Comprehensive Review of COVID-19 Associated Neurological Manifestations. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33688035&form=6&db=m One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection. ongoing research,therapeutic application,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33692203&form=6&db=m Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706683&form=6&db=m Potential inhibitors of angiotensin converting enzyme 2 receptor of COVID-19 by Corchorus olitorius Linn using docking, molecular dynamics, conceptual DFT investigation and pharmacophore mapping. ongoing research,therapeutic application,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33714595&form=6&db=m Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33718434&form=6&db=m Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection. therapeutic application,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33737961&form=6&db=m The Renin-Angiotensin-Aldosterone System and Coronavirus Disease 2019. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33752217&form=6&db=m Variants in ACE2 and TMPRSS2 Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank Subjects. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762412&form=6&db=m Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762895&form=6&db=m Revealing the mechanism of SARS-CoV-2 spike protein binding with ACE2. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33763052&form=6&db=m Epidemiological Study of Betacoronaviruses in Captive Malayan Pangolins. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33785634&form=6&db=m Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33792473&form=6&db=m Perspective: the nose and the stomach play a critical role in the NZACE2-P?tari* (modified ACE2) drug treatment project of SARS-CoV-2 infection. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794092&form=6&db=m Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33796097&form=6&db=m Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33809851&form=6&db=m The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33811970&form=6&db=m Effect of ramipril on kidney, lung and heart ACE2 in a diabetic mice model. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33820827&form=6&db=m Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821207&form=6&db=m Renal Injury by SARS-CoV-2 Infection: A Systematic Review. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821288&form=6&db=m Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33824288&form=6&db=m Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33835386&form=6&db=m Scientific Hypothesis for Treatment of COVID-19's Lung Lesions by Adjusting ACE/ACE2 Imbalance. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33836016&form=6&db=m Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33838638&form=6&db=m Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33844653&form=6&db=m Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851150&form=6&db=m Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33853637&form=6&db=m Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33865974&form=6&db=m Oral antiseptics against coronavirus: in-vitro and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33880537&form=6&db=m ACE2, TMPRSS2 and L-SIGN expression in placentae from HIV-positive pregnancies exposed to antiretroviral therapy-implications for SARS-CoV-2 placental infection. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33885726&form=6&db=m Comparative phylogenetic analysis of SARS-CoV-2 spike protein-possibility effect on virus spillover. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893649&form=6&db=m Tackling Covid-19 using disordered-to-order transition of residues in the spike protein upon angiotensin-converting enzyme 2 binding. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33900165&form=6&db=m Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other Viruses. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33911464&form=6&db=m COVID-19 and the gastrointestinal tract: Source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection? causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33914873&form=6&db=m Animal Models of COVID-19 II. Comparative Immunology. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917481&form=6&db=m Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33926459&form=6&db=m A novel pseudovirus-based mouse model of SARS-CoV-2 infection to test COVID-19 interventions. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33927728&form=6&db=m Interplay of Opposing Effects of the WNT/?-Catenin Pathway and PPAR? and Implications for SARS-CoV2 Treatment. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33936927&form=6&db=m Mutational heterogeneity in spike glycoproteins of severe acute respiratory syndrome coronavirus 2. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937568&form=6&db=m COVID-19 and bronchial asthma: current perspectives. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33962399&form=6&db=m Low plasma angiotensin-converting enzyme 2 level in diabetics increases the risk of severe COVID-19 infection. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969320&form=6&db=m Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33974296&form=6&db=m Comparative analyses of ACE2 and TMPRSS2 gene: Implications for the risk to which vertebrate animals are susceptible to SARS-CoV-2. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33974566&form=6&db=m Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33974910&form=6&db=m Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33978304&form=6&db=m Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33980675&form=6&db=m A Cytopathic Effect-Based Tissue Culture Method for HCoV-OC43 Titration Using TMPRSS2-Expressing VeroE6 Cells. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984877&form=6&db=m Role of ACE2 polymorphism in COVID-19: impact of age. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33992054&form=6&db=m Structural Basis for the Understanding of Entry Inhibitors Against SARS Viruses. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33993052&form=6&db=m Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33994655&form=6&db=m An insight into the inhibitory mechanism of phytochemicals and FDA-approved drugs on the ACE2-Spike complex of SARS-CoV-2 using computational methods. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34002118&form=6&db=m Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34010445&form=6&db=m Endocrine and metabolic aspects of COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34012108&form=6&db=m A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34033751&form=6&db=m COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury. diagnostic usage,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34048906&form=6&db=m Do inflammaging and coagul-aging play a role as conditions contributing to the co-occurrence of the severe hyper-inflammatory state and deadly coagulopathy during COVID-19 in older people? causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34060982&form=6&db=m H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34064066&form=6&db=m Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073591&form=6&db=m Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085038&form=6&db=m EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34086837&form=6&db=m Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094635&form=6&db=m Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell Level. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34097570&form=6&db=m A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34100014&form=6&db=m Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102962&form=6&db=m The roles of vitamin D in increasing the body's immunity and reducing injuries due to viral infections: With an emphasis on its possible role in SARS-CoV-2 (COVID-19). causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34123321&form=6&db=m Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34133899&form=6&db=m Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34140558&form=6&db=m An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants. therapeutic application,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151392&form=6&db=m The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34156227&form=6&db=m Anchor-Locker Binding Mechanism of the Coronavirus Spike Protein to Human ACE2: Insights from Computational Analysis. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34159616&form=6&db=m TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163106&form=6&db=m COVID-19-associated diarrhea. diagnostic usage,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34171382&form=6&db=m Zinc supplementation augments the suppressive effects of repurposed NF-?B inhibitors on ACE2 expression in human lung cell lines. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34174177&form=6&db=m Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34180984&form=6&db=m Computational design of ultrashort peptide inhibitors of the receptor-binding domain of the SARS-CoV-2 S protein. therapeutic application,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34184164&form=6&db=m COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34188786&form=6&db=m Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34190246&form=6&db=m Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34191346&form=6&db=m Plasma ACE2 species are differentially altered in COVID-19 patients. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201505&form=6&db=m The Fight against COVID-19 on the Multi-Protease Front and Surroundings: Could an Early Therapeutic Approach with Repositioning Drugs Prevent the Disease Severity? causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214539&form=6&db=m Small molecule therapeutics to destabilize the ACE2-RBD complex: A molecular dynamics study. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230708&form=6&db=m A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism. ongoing research,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230799&form=6&db=m Angiotensin-converting enzyme 2 gene expression in human male urological tissues: implications for pathogenesis and virus transmission pathways. ongoing research,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34246735&form=6&db=m A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34248311&form=6&db=m Genetic Control of Human Infection with SARS-CoV-2. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34251748&form=6&db=m A computational study of the interface interaction between SARS-CoV-2 RBD and ACE2 from human, cat, dog, and ferret. causal interaction,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34259961&form=6&db=m Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19 - a Primer for Clinicians. causal interaction,unassigned 3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34293134&form=6&db=m Is SARS-CoV-2 infection a risk factor for early pregnancy loss? ACE2 and TMPRSS2 co-expression and persistent replicative infection in primitive trophoblast. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34294757&form=6&db=m High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34299289&form=6&db=m Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305426&form=6&db=m RAAS, ACE2 and COVID-19; a mechanistic review. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34319155&form=6&db=m Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34321523&form=6&db=m A surrogate virus neutralization test to quantify antibody-mediated inhibition of SARS-CoV-2 in finger stick dried blood spot samples. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34325716&form=6&db=m Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34328182&form=6&db=m Roles of steroid receptors in the lung and COVID-19. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34329437&form=6&db=m Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34336361&form=6&db=m A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34340553&form=6&db=m The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34354803&form=6&db=m Acute mesenteric ischemia and small bowel imaging findings in COVID-19: A comprehensive review of the literature. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34365591&form=6&db=m Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34381960&form=6&db=m The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34386518&form=6&db=m Non-RBM Mutations Impaired SARS-CoV-2 Spike Protein Regulated to the ACE2 Receptor Based on Molecular Dynamic Simulation. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34390895&form=6&db=m The use of negative oxygen ion clusters [O2-(H2O)n] and bicarbonate ions [HCO3-] as the supportive treatment of COVID-19 infections: A possibility. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395033&form=6&db=m Coronavirus Disease 2019 Infection among Children: Pathogenesis, Treatment, and Outcome. causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406858&form=6&db=m Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406864&form=6&db=m TMPRSS2 activates hemagglutinin-esterase glycoprotein of influenza C virus. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34410424&form=6&db=m Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34410599&form=6&db=m PM2.5, NO2, wildfires, and other environmental exposures are linked to higher Covid 19 incidence, severity, and death rates. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413390&form=6&db=m Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34420993&form=6&db=m The expression of hACE2 receptor protein and its involvement in SARS-CoV-2 entry, pathogenesis, and its application as potential therapeutic target. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34420994&form=6&db=m The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34428473&form=6&db=m The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccines. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429799&form=6&db=m Ogilvie Syndrome and COVID-19 Infection. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433426&form=6&db=m Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433867&form=6&db=m Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34435559&form=6&db=m The roles of nausea and vomiting in COVID-19: did we miss something? causal interaction,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34444960&form=6&db=m Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34451902&form=6&db=m Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34452517&form=6&db=m The Microvillar and Solitary Chemosensory Cells as the Novel Targets of Infection of SARS-CoV-2 in Syrian Golden Hamsters. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34452531&form=6&db=m Peptide Platform as a Powerful Tool in the Fight against COVID-19. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34458381&form=6&db=m Interaction of SARS-CoV-2 spike protein with angiotensin converting enzyme inhibitors and selected compounds from the chemical entities of biological interest. therapeutic application,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34461258&form=6&db=m SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34461999&form=6&db=m Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34463644&form=6&db=m Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2 transgenic mice. ongoing research,unassigned 4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34474709&form=6&db=m Sustained decrease in pediatric asthma emergency visits during the first year of the COVID-19 pandemic. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483599&form=6&db=m Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34485782&form=6&db=m Structural Behavior of Monomer of SARS-CoV-2 Spike Protein during Initial Stage of Adsorption on Graphene. ongoing research,unassigned 2,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497376&form=6&db=m Neutralizing antibodies for the prevention and treatment of COVID-19. unassigned - 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34499924&form=6&db=m Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif. causal interaction,unassigned 1,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514615&form=6&db=m Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531369&form=6&db=m S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. ongoing research,unassigned 2,0 3.4.17.23 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33151050&form=6&db=m Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.4.17.23 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34547545&form=6&db=m Understanding the cross-talk between mediators of infertility and COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006953&form=6&db=m Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility. causal interaction,unassigned 1,0 3.4.17.23 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34204705&form=6&db=m In Silico Identification of miRNA-lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 Infection. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.4.17.23 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26963721&form=6&db=m Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. causal interaction,unassigned 3,0 3.4.17.23 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32413354&form=6&db=m Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32553760&form=6&db=m TNF?-antagonist use and mucosal inflammation are associated with increased intestinal expression of SARS-CoV-2 host protease TMPRSS2 in patients with inflammatory bowel disease. causal interaction,unassigned 4,0 3.4.17.23 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676577&form=6&db=m A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19. causal interaction,unassigned 2,0 3.4.17.23 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059040&form=6&db=m Benign Evolution of SARS-Cov2 Infections in Children With Inflammatory Bowel Disease: Results From Two International Databases. causal interaction,unassigned 4,0 3.4.17.23 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33156843&form=6&db=m A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. causal interaction,unassigned 2,0 3.4.17.23 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24800825&form=6&db=m Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33820827&form=6&db=m Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza. causal interaction,unassigned 1,0 3.4.17.23 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34319155&form=6&db=m Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16973594&form=6&db=m Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19158246&form=6&db=m Proteolytic activation of the 1918 influenza virus hemagglutinin. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19840668&form=6&db=m MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237084&form=6&db=m Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20629046&form=6&db=m Novel insights into proteolytic cleavage of influenza virus hemagglutinin. unassigned - 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631123&form=6&db=m TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20926566&form=6&db=m Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21123387&form=6&db=m Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2. ongoing research,therapeutic application,unassigned 4,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325420&form=6&db=m Evidence that TMPRSS2 activates the SARS-coronavirus spike-protein for membrane fusion and reduces viral control by the humoral immune response. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22558251&form=6&db=m Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23072892&form=6&db=m Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23192872&form=6&db=m Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses. unassigned - 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23365447&form=6&db=m Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23527573&form=6&db=m Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23577043&form=6&db=m The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23821437&form=6&db=m Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155384&form=6&db=m Activation of influenza A viruses by host proteases from swine airway epithelium. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24348248&form=6&db=m Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24522916&form=6&db=m TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24600012&form=6&db=m The host protease TMPRSS2 plays a major role for in vivo replication of emerging H7N9 and seasonal influenza viruses. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24662240&form=6&db=m Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus. causal interaction,unassigned 2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122802&form=6&db=m DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25391767&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25673722&form=6&db=m A Mutant H3N2 Influenza Virus Uses an Alternative Activation Mechanism in TMPRSS2 Knockout Mice by Loss of an Oligosaccharide in the Hemagglutinin Stalk Region. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904605&form=6&db=m Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25918647&form=6&db=m Establishment of MDCK Stable Cell Lines Expressing TMPRSS2 and MSPL and Their Applications in Propagating Influenza Vaccine Viruses in Absence of Exogenous Trypsin. ongoing research,unassigned 3,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379044&form=6&db=m TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells. causal interaction,unassigned 4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26889029&form=6&db=m The proteolytic activation of A (H3N2) Influenza virus hemagglutinin is facilitated by different type II transmembrane serine proteases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27028521&form=6&db=m The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells. unassigned - 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277342&form=6&db=m In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27389476&form=6&db=m TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus. ongoing research,therapeutic application,unassigned 1,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28493964&form=6&db=m Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28778717&form=6&db=m TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30084768&form=6&db=m Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice. ongoing research,therapeutic application,unassigned 1,2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31099738&form=6&db=m Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis. ongoing research,unassigned 2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31391268&form=6&db=m TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32056846&form=6&db=m SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses. ongoing research,therapeutic application,unassigned 2,3,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32267499&form=6&db=m The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease. causal interaction,unassigned 1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321537&form=6&db=m H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32376987&form=6&db=m Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32574272&form=6&db=m Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets? therapeutic application,unassigned 1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32695180&form=6&db=m Coupled CRC 2D and ALI 3D Cultures Express Receptors of Emerging Viruses and Are More Suitable for the Study of Viral Infections Compared to Conventional Cell Lines. therapeutic application,unassigned 1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32938895&form=6&db=m [Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2]. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33017910&form=6&db=m Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease. ongoing research,unassigned 3,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33176395&form=6&db=m Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33244671&form=6&db=m A Case-Control Study of the 2019 Influenza Vaccine and Incidence of COVID-19 Among Healthcare Workers. therapeutic application,unassigned 1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33333995&form=6&db=m Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives. therapeutic application,unassigned 1,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417604&form=6&db=m Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2). causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609069&form=6&db=m Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33968142&form=6&db=m Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34198852&form=6&db=m Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity. causal interaction,unassigned 2,0 3.4.17.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34406864&form=6&db=m TMPRSS2 activates hemagglutinin-esterase glycoprotein of influenza C virus. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22933108&form=6&db=m Loss of ACE 2 Exaggerates High-Calorie Diet-Induced Insulin Resistance by Reduction of GLUT4 in Mice. ongoing research,unassigned 1,0 3.4.17.23 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25666042&form=6&db=m Angiotensin Converting Enzyme 2 Activator DIZE Modulates Metabolic Profile in Mice Decreasing Lipogenesis. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065163&form=6&db=m Metabolic impact of weight loss induced reduction of adipose ACE-2 - Potential implication in COVID-19 infections? causal interaction,unassigned 3,0 3.4.17.23 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708129&form=6&db=m Ginsenoside Rc Ameliorates Endothelial Insulin Resistance via Upregulation of Angiotensin-Converting Enzyme 2. unassigned - 3.4.17.23 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33815295&form=6&db=m The Efficacy and Potential Mechanisms of Metformin in the Treatment of COVID-19 in the Diabetics: A Systematic Review. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813695&form=6&db=m [Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke.] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142453&form=6&db=m Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25941346&form=6&db=m Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.4.17.23 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27488276&form=6&db=m Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.17.23 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34124808&form=6&db=m Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34085038&form=6&db=m EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases. causal interaction,unassigned 3,0 3.4.17.23 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24203630&form=6&db=m ACE and ACE2 expression in normal and malignant skin lesions. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367030&form=6&db=m Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408475&form=6&db=m New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19077694&form=6&db=m Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease. ongoing research,therapeutic application,unassigned 2,2,0 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28501298&form=6&db=m ACE2 as therapy for glomerular disease: the devil is in the detail. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32691044&form=6&db=m Circulating plasma angiotensin-converting enzyme 2 concentration is elevated in patients with kidney disease and diabetes. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32691065&form=6&db=m Circulating plasma angiotensin-converting enzyme 2 concentrations in patients with kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617712&form=6&db=m Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019. therapeutic application,unassigned 1,0 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34097714&form=6&db=m Sex and kidney ACE2 expression in primary focal segmental glomerulosclerosis: A NEPTUNE study. causal interaction,unassigned 2,0 3.4.17.23 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177593&form=6&db=m A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency. causal interaction,unassigned 3,0 3.4.17.23 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151079&form=6&db=m Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems. therapeutic application,unassigned 2,0 3.4.17.23 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131396&form=6&db=m Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.4.17.23 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307238&form=6&db=m Angiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyoma. causal interaction,unassigned 4,0 3.4.17.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486379&form=6&db=m A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection? diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424597&form=6&db=m Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23663763&form=6&db=m [Expression and correlation of angiotensin-converting enzyme 2 in CCl4-induced rat liver fibrosis]. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.17.23 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25887687&form=6&db=m Impact of hepatic immunoreactivity of angiotensin-converting enzyme 2 on liver fibrosis due to non-alcoholic steatohepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25997428&form=6&db=m ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice. therapeutic application,unassigned 3,0 3.4.17.23 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29977014&form=6&db=m The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice. ongoing research,therapeutic application,unassigned 4,3,0 3.4.17.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17532087&form=6&db=m Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.17.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20535005&form=6&db=m Hepatic Fibrosis and the Renin-Angiotensin System. unassigned - 3.4.17.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30604460&form=6&db=m Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease. unassigned - 3.4.17.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437004&form=6&db=m Hepatic complications of COVID-19 and its treatment. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33968947&form=6&db=m Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction. ongoing research,unassigned 2,0 3.4.17.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34079691&form=6&db=m Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16315782&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16581295&form=6&db=m Angiotensin-converting enzyme 2 in lung diseases. therapeutic application,unassigned 3,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19246717&form=6&db=m Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370913&form=6&db=m Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665060&form=6&db=m Hyperoxia Downregulates Angiotensin Converting Enzyme-2 (ACE-2) in Human Fetal Lung Fibroblasts. causal interaction,unassigned 4,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27019629&form=6&db=m Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27082314&form=6&db=m Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935640&form=6&db=m Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29806050&form=6&db=m Roles of the Angiotensin System in Neonatal Lung Injury and Disease. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33184236&form=6&db=m SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. causal interaction,ongoing research,unassigned 2,2,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33419885&form=6&db=m Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356070&form=6&db=m Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34375388&form=6&db=m Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.17.23 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34410424&form=6&db=m Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Lung Diseases, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485164&form=6&db=m A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16007097&form=6&db=m A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. causal interaction,unassigned 2,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691016&form=6&db=m Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers. ongoing research,therapeutic application,unassigned 2,3,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851091&form=6&db=m Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22205632&form=6&db=m LPS-Stimulated Cytokine Production in Type I Cells is Modulated by the Renin-Angiotensin System. causal interaction,unassigned 3,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22246130&form=6&db=m Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25291359&form=6&db=m Mesenchymal Stem Cells Overexpressing Angiotensin-Converting Enzyme 2 Rescue Lipopolysaccharide-Induced Lung Injury. causal interaction,ongoing research,unassigned 2,2,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25768373&form=6&db=m Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25998889&form=6&db=m Angiotensin-Converting Enzyme 2 Attenuates Bleomycin-Induced Lung Fibrosis in Mice. causal interaction,unassigned 4,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26813885&form=6&db=m Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27062780&form=6&db=m [Protective Effect of Angiotensin Converting Enzyme 2 (ACE2) Against Chronic Intermittent Hypoxia-induced Pulmonary Oxidative Stress Injury in Rats]. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29806050&form=6&db=m Roles of the Angiotensin System in Neonatal Lung Injury and Disease. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31393582&form=6&db=m Angiotensin-converting enzyme 2 attenuates inflammatory response and oxidative stress in hyperoxic lung injury by regulating NF-?B and Nrf2 pathways. causal interaction,unassigned 3,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32404898&form=6&db=m Diabetes and COVID-19: evidence, current status and unanswered research questions. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428864&form=6&db=m Angiotensin converting enzyme-2 as therapeutic target in COVID-19. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550243&form=6&db=m Prediction of repurposed drugs for treating lung injury in COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584474&form=6&db=m A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32613681&form=6&db=m Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32735889&form=6&db=m Angiotensin-Converting Enzyme Gene Polymorphism and Severe Lung Injury in Patients with Coronavirus Disease 2019. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32934806&form=6&db=m Prediction of repurposed drugs for treating lung injury in COVID-19. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050860&form=6&db=m COVID-19 and Renal Diseases: An Update. causal interaction,unassigned 1,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080435&form=6&db=m The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525252&form=6&db=m The role of angiotensin-converting enzyme 2 in COVID-19 induced lung injury. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195577&form=6&db=m A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19. ongoing research,unassigned 2,0 3.4.17.23 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34358119&form=6&db=m Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204277&form=6&db=m The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23545945&form=6&db=m Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition. causal interaction,unassigned 3,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636159&form=6&db=m Association between Serum Angiotensin-converting Enzyme 2 Level with Postoperative Morbidity and Mortality after Major Pulmonary Resection in Non-small Cell Lung Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023337&form=6&db=m ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32764454&form=6&db=m SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32916258&form=6&db=m Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967703&form=6&db=m TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973879&form=6&db=m Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33425965&form=6&db=m Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells. causal interaction,unassigned 1,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484868&form=6&db=m Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486379&form=6&db=m A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection? diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33585826&form=6&db=m Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes. diagnostic usage,unassigned 3,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33723522&form=6&db=m ACE2: At the crossroad of COVID-19 and lung cancer. causal interaction,diagnostic usage,unassigned 2,2,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094684&form=6&db=m Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail. causal interaction,unassigned 3,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094930&form=6&db=m High Expression of ACE2 and TMPRSS2 at the Resection Margin Makes Lung Cancer Survivors Susceptible to SARS-CoV-2 With Unfavorable Prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151202&form=6&db=m Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis. ongoing research,unassigned 1,0 3.4.17.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168096&form=6&db=m In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.17.23 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951139&form=6&db=m TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33973418&form=6&db=m Protective effect of recombinant Lactobacillus plantarum against H2O2-induced oxidative stress in HUVEC cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33134395&form=6&db=m Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region. causal interaction,unassigned 4,0 3.4.17.23 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28637803&form=6&db=m Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Meconium Aspiration Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30759273&form=6&db=m Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome. causal interaction,ongoing research,unassigned 2,2,0 3.4.17.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30792990&form=6&db=m Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32374427&form=6&db=m Expression of the COVID-19 receptor ACE2 in the human conjunctiva. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528526&form=6&db=m Expression of innate immune response genes in upper airway samples of SARS-CoV-2 infected patients: A preliminary study. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.17.23 Meningomyelocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32648420&form=6&db=m Study of serum and urinary markers of the renin-angiotensin-aldosterone system in myelomeningocele patients with renal injury detected by DMSA. diagnostic usage,unassigned 2,0 3.4.17.23 Mesenteric Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34354803&form=6&db=m Acute mesenteric ischemia and small bowel imaging findings in COVID-19: A comprehensive review of the literature. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017239&form=6&db=m Angiotensin 1-7: A peptide for preventing and treating metabolic syndrome. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16459167&form=6&db=m Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071265&form=6&db=m [Effect of Astragali Radix in improving early renal damage in metabolic syndrome rats through ACE2/Mas pathway]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33124044&form=6&db=m Are Migraine Patients at Increased Risk for Symptomatic Coronavirus Disease 2019 Due to Shared Comorbidities? unassigned - 3.4.17.23 Movement Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230886&form=6&db=m De Novo Movement Disorders and COVID-19: Exploring the Interface. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584199&form=6&db=m Human and novel coronavirus infections in children: a review. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33677852&form=6&db=m Is multisystem inflammatory syndrome related with coronavirus disease 2019, Kawasaki disease, and angiotensin-converting enzyme 2 in children? causal interaction,unassigned 4,0 3.4.17.23 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32691890&form=6&db=m ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.17.23 Muscle Weakness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30207087&form=6&db=m Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Muscle Weakness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31853045&form=6&db=m Different effects of the deletion of angiotensin converting enzyme 2 and chronic activation of the renin-angiotensin system on muscle weakness in middle-aged mice. ongoing research,therapeutic application,unassigned 4,2,0 3.4.17.23 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32578794&form=6&db=m Sars-CoV-2: A clinical update - II. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15007027&form=6&db=m Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. causal interaction,therapeutic application,unassigned 2,3,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808375&form=6&db=m Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20507236&form=6&db=m ACE2 Overexpression Improves Left Ventricular Remodeling and Function in Rats with Myocardial Infarction. therapeutic application,unassigned 4,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22381157&form=6&db=m N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery. diagnostic usage,unassigned 2,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22715807&form=6&db=m Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23630610&form=6&db=m Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: a prospective controlled study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23959549&form=6&db=m Diminazene aceturate enhances Angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24134599&form=6&db=m Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24926374&form=6&db=m Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28501115&form=6&db=m Postconditioning attenuates coronary perivascular and interstitial fibrosis through modulating angiotensin II receptors and angiotensin-converting enzyme 2 after myocardial infarction. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30092400&form=6&db=m The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32458737&form=6&db=m Differences in the expression of the renin angiotensin system and the kallikrein-kinin system during the course of myocardial infarction in male and female Wistar rats. ongoing research,unassigned 4,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32947927&form=6&db=m Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies. causal interaction,unassigned 4,0 3.4.17.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33166657&form=6&db=m Clinically Suspected Myocarditis in the Course of Severe Acute Respiratory Syndrome Novel Coronavirus-2 Infection: Fact or Fiction? causal interaction,unassigned 4,0 3.4.17.23 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32467423&form=6&db=m Potential mechanisms of cardiac injury and common pathways of inflammation in patients with COVID-19. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32874745&form=6&db=m Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0 3.4.17.23 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33981235&form=6&db=m Phytochemicals as Potential Therapeutics for SARS-CoV-2-Induced Cardiovascular Complications: Thrombosis and Platelet Perspective. unassigned - 3.4.17.23 Myositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652140&form=6&db=m Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245484&form=6&db=m Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15537383&form=6&db=m The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951139&form=6&db=m TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338334&form=6&db=m The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23545945&form=6&db=m Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition. causal interaction,unassigned 3,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122198&form=6&db=m The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25179500&form=6&db=m Prostate cancer: TMPRSS2 promotes metastasis through proteolysis. causal interaction,unassigned 2,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25367948&form=6&db=m Insights into the mechanism of organ-specific cancer metastasis. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26018085&form=6&db=m Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935606&form=6&db=m Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin?induced cell death. causal interaction,unassigned 1,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277342&form=6&db=m In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32778768&form=6&db=m Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292131&form=6&db=m Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.4.17.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34150618&form=6&db=m Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245484&form=6&db=m Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11414763&form=6&db=m Mutation analyses of 268 candidate genes in human tumor cell lines. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745466&form=6&db=m The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15537383&form=6&db=m The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079440&form=6&db=m TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17334351&form=6&db=m A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17458530&form=6&db=m [TMPRSS2-ETS gene fusion in prostate cancer] unassigned - 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17804708&form=6&db=m Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18240415&form=6&db=m Words of wisdom. Re: duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338334&form=6&db=m The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19212105&form=6&db=m Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression. causal interaction,unassigned 4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19242826&form=6&db=m Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19597533&form=6&db=m Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759332&form=6&db=m Selective and Specific Regulation of Ectodomain Shedding of Angiotensin-converting Enzyme 2 by Tumor Necrosis Factor {alpha}-converting Enzyme. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851091&form=6&db=m Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118910&form=6&db=m Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204277&form=6&db=m The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382709&form=6&db=m TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells. causal interaction,ongoing research,unassigned 3,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20473283&form=6&db=m ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20493449&form=6&db=m [What's new in 2009 in prostate cancer: highlights from ASTRO, EAU, ASCO and AUA meetings] diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601956&form=6&db=m Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736744&form=6&db=m Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20947519&form=6&db=m Androgen-induced TMPRSS2:ERG fusion in non-malignant prostate epithelial cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20957673&form=6&db=m A multiplex model of combining gene-based, protein-based, and metabolite-based with positive and negative markers in urine for the early diagnosis of prostate cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21994901&form=6&db=m Chromosome rearrangement associated inactivation of tumour suppressor genes in prostate cancer. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22430804&form=6&db=m Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma. ongoing research,unassigned 2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151079&form=6&db=m Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems. therapeutic application,unassigned 2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23244085&form=6&db=m Fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers from northern China. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23512661&form=6&db=m ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. causal interaction,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23527573&form=6&db=m Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23535644&form=6&db=m Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24445296&form=6&db=m Commentary on "ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients." Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z, Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, USA.: Genes Dev 2013;27(6):683-98. causal interaction,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25088707&form=6&db=m Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth. unassigned - 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122198&form=6&db=m The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25367948&form=6&db=m Insights into the mechanism of organ-specific cancer metastasis. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25563374&form=6&db=m Prognostic and predictive molecular biological markers in prostate cancer - significance of expression of genes PCA3 and TMPRSS2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701390&form=6&db=m The association of renin-angiotensin system genes with the progression of hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25734995&form=6&db=m TMPRSS2, a novel membrane-anchored mediator in cancer pain. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25977336&form=6&db=m NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26018085&form=6&db=m Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556707&form=6&db=m Angiotensin-(1-7) Attenuates Kidney Injury Due to Obstructive Nephropathy in Rats. ongoing research,unassigned 2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26665675&form=6&db=m [Relationship between TMPRSS2: ERG and the pathological grade of prostate cancer]. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26837907&form=6&db=m Molecular Pathology of the Genitourinary Tract: Prostate and Bladder. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935606&form=6&db=m Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin?induced cell death. causal interaction,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27626314&form=6&db=m The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer. causal interaction,unassigned 3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27753122&form=6&db=m Calcium Channel Blocker Use and Risk of Prostate Cancer by TMPRSS2:ERG Gene Fusion Status. therapeutic application,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27956412&form=6&db=m Expression of renin-angiotensin system (RAS) components in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28324007&form=6&db=m Aberrant TGF-? Signaling Drives Castration-Resistant Prostate Cancer in a Male Mouse Model of Prostate Tumorigenesis. causal interaction,unassigned 2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28403781&form=6&db=m Design, synthesis and biological evaluation of novel 1, 3-thiazolidine-2, 4-diones as anti-prostate cancer agents. unassigned - 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849022&form=6&db=m Significance of the TMPRSS2:ERG gene fusion in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28900498&form=6&db=m Correlation between ERG Fusion Protein and Androgen Receptor Expression by Immunohistochemistry in Prostate, Possible Role in Diagnosis and Therapy. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29218249&form=6&db=m Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases. causal interaction,unassigned 2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29670000&form=6&db=m Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity. diagnostic usage,unassigned 4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786791&form=6&db=m Protocols for Studies on TMPRSS2/ERG in Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367117&form=6&db=m Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer. unassigned - 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30792990&form=6&db=m Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30892142&form=6&db=m The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31303963&form=6&db=m Comparative RNA-seq analysis reveals dys-regulation of major canonical pathways in ERG-inducible LNCaP cell progression model of prostate cancer. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31308362&form=6&db=m Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms. causal interaction,unassigned 4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31494171&form=6&db=m Underlying mechanisms behind the protective effect of angiotensin (1-7) in experimental rat model of ovarian ischemia reperfusion injury. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32366279&form=6&db=m Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis. causal interaction,unassigned 4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32387456&form=6&db=m Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32412310&form=6&db=m The management of patients with metastatic prostate cancer during the COVID-19 pandemic. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32432519&form=6&db=m Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)? ongoing research,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468052&form=6&db=m Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584199&form=6&db=m Human and novel coronavirus infections in children: a review. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32664879&form=6&db=m New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,3 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675312&form=6&db=m ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32705281&form=6&db=m Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726325&form=6&db=m Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32731090&form=6&db=m SARS-CoV-2 and cancer: Are they really partners in crime? causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32738184&form=6&db=m Tumor markers as an entry for SARS-CoV-2 infection? diagnostic usage,therapeutic application,unassigned 1,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742475&form=6&db=m Expression of the SAR2-Cov-2 receptor ACE2 reveals the susceptibility of COVID-19 in non-small cell lung cancer. causal interaction,unassigned 3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32778768&form=6&db=m Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32822911&form=6&db=m A combinational approach to restore cytokine balance and to inhibit virus growth may promote patient recovery in severe COVID-19 cases. causal interaction,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967703&form=6&db=m TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32970391&form=6&db=m An investigation into the molecular basis of cancer comorbidities in coronavirus infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33051304&form=6&db=m Similarities in Risk for COVID-19 and Cancer Disparities. causal interaction,unassigned 4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061814&form=6&db=m Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080435&form=6&db=m The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33082849&form=6&db=m Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transition. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33108902&form=6&db=m ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33153403&form=6&db=m Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection? causal interaction,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178900&form=6&db=m SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193689&form=6&db=m TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33195212&form=6&db=m The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma Patients. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33238655&form=6&db=m Sirt1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes. diagnostic usage,therapeutic application,unassigned 4,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254543&form=6&db=m Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292131&form=6&db=m Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33328008&form=6&db=m [A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019]. unassigned - 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33340650&form=6&db=m Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases. unassigned - 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33415017&form=6&db=m Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421977&form=6&db=m Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479506&form=6&db=m High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33484868&form=6&db=m Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33522308&form=6&db=m Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33531686&form=6&db=m More light on cancer and COVID-19 reciprocal interaction. unassigned - 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609069&form=6&db=m Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614513&form=6&db=m Landscape Profiling Analysis of DPP4 in Malignancies: Therapeutic Implication for Tumor Patients With Coronavirus Disease 2019. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33629341&form=6&db=m Differential expression and immune correlation analysis of COVID-19 receptor ACE2 and TMPRSS2 genes in all normal and tumor tissues. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33707526&form=6&db=m Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732005&form=6&db=m Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers. ongoing research,unassigned 3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738043&form=6&db=m Angiotensin-converting enzyme 2 connects COVID-19 with cancer and cancer immunotherapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754609&form=6&db=m Effects of COVID-19 on male sex function and its potential sexual transmission. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33796097&form=6&db=m Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33797339&form=6&db=m COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33912588&form=6&db=m The Deadly Duo of COVID-19 and Cancer! causal interaction,unassigned 4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935396&form=6&db=m Acute Kidney Injury in COVID-19: a Brief Review. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34048828&form=6&db=m Novel Case of Isolated Peritoneal Carcinomatosis from Metastatic Prostate Cancer Carrying a Pathogenic BRCA Mutation Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. causal interaction,unassigned 2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131396&form=6&db=m Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34138483&form=6&db=m Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168096&form=6&db=m In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34171559&form=6&db=m COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenario. therapeutic application,unassigned 1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34203261&form=6&db=m Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral Particles. ongoing research,therapeutic application,unassigned 1,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249149&form=6&db=m Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecular mimicry phenomena? Two not mutually exclusive hypotheses. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257580&form=6&db=m Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34339474&form=6&db=m Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies. diagnostic usage,ongoing research,unassigned 2,4,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34399734&form=6&db=m Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34420994&form=6&db=m The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34458283&form=6&db=m Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528526&form=6&db=m Expression of innate immune response genes in upper airway samples of SARS-CoV-2 infected patients: A preliminary study. diagnostic usage,ongoing research,unassigned 4,2,0 3.4.17.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34541033&form=6&db=m Loss of CDCP1 triggers FAK activation in detached prostate cancer cells. unassigned - 3.4.17.23 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34541033&form=6&db=m Loss of CDCP1 triggers FAK activation in detached prostate cancer cells. unassigned - 3.4.17.23 Nephritis, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28501298&form=6&db=m ACE2 as therapy for glomerular disease: the devil is in the detail. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514826&form=6&db=m Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome. therapeutic application,unassigned 3,0 3.4.17.23 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25680080&form=6&db=m The Implications of Angiotensin-Converting Enzymes and Their Modulators in Neurodegenerative Disorders: Current and Future Perspectives. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31987854&form=6&db=m Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice. causal interaction,ongoing research,unassigned 3,3,0 3.4.17.23 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197881&form=6&db=m Role of angiotensin-converting enzyme 2 in neurodegenerative diseases during the COVID-19 pandemic. unassigned - 3.4.17.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33550782&form=6&db=m CNS implications of COVID-19: a comprehensive review. causal interaction,unassigned 4,0 3.4.17.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708124&form=6&db=m Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic Approach. therapeutic application,unassigned 1,0 3.4.17.23 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33060875&form=6&db=m Coronavirus Disease 2019: Latest Data on Neuroinvasive Potential. causal interaction,unassigned 4,0 3.4.17.23 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33175635&form=6&db=m Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34289037&form=6&db=m Emerging neurotropic features of SARS-CoV-2. unassigned - 3.4.17.23 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24558317&form=6&db=m Pioglitazone upregulates angiotensin converting enzyme 2 expression in insulin-sensitive tissues in rats with high-fat diet-induced nonalcoholic steatohepatitis. unassigned - 3.4.17.23 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30604460&form=6&db=m Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease. unassigned - 3.4.17.23 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486379&form=6&db=m A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection? diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15078862&form=6&db=m Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination? ongoing research,unassigned 4,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460555&form=6&db=m Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32339391&form=6&db=m The Role of Adipocytes and Adipocyte-Like Cells in the Severity of COVID-19 Infections. causal interaction,unassigned 4,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32451913&form=6&db=m Obesity and COVID-19: ACE 2, the Missing Tile. unassigned - 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32593740&form=6&db=m Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture. causal interaction,unassigned 4,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32721806&form=6&db=m Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS). causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32843118&form=6&db=m Nutritional status, diet and viral respiratory infections: perspectives for SARS-CoV-2. causal interaction,unassigned 4,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953947&form=6&db=m SARS-CoV-2 infection: physiological and environmental gift factors at high altitude. unassigned - 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33071815&form=6&db=m Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19. unassigned - 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33083805&form=6&db=m Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33168188&form=6&db=m Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19. causal interaction,therapeutic application,unassigned 1,2,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33909265&form=6&db=m Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives. causal interaction,unassigned 4,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34067683&form=6&db=m Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients. causal interaction,unassigned 4,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177593&form=6&db=m A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency. causal interaction,unassigned 3,0 3.4.17.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34484128&form=6&db=m COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury. causal interaction,unassigned 4,0 3.4.17.23 Oral Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33021087&form=6&db=m How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease. causal interaction,unassigned 4,0 3.4.17.23 Orchitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232425&form=6&db=m COVID-19 and male reproductive system: pathogenic features and possible mechanisms. therapeutic application,unassigned 1,0 3.4.17.23 Orthomyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24348248&form=6&db=m Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22076164&form=6&db=m The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.17.23 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481527&form=6&db=m Angiotensin-converting enzyme 2 acts as a potential molecular target for pancreatic cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.17.23 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34160253&form=6&db=m Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat. therapeutic application,unassigned 4,0 3.4.17.23 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32374427&form=6&db=m Expression of the COVID-19 receptor ACE2 in the human conjunctiva. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23966399&form=6&db=m TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses. causal interaction,ongoing research,unassigned 3,2,0 3.4.17.23 peptidyl-dipeptidase a deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519526&form=6&db=m Serum Renin Levels Increase With Age in Boys Resulting in Higher Renin Levels in Young Men Compared to Young Women, and Soluble Angiotensin-Converting Enzyme 2 Correlates With Renin and Body Mass Index. causal interaction,unassigned 4,0 3.4.17.23 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33897916&form=6&db=m Making a complex dental care tailored to the person: population health in focus of predictive, preventive and personalised (3P) medical approach. causal interaction,unassigned 3,0 3.4.17.23 Periodontal Pocket http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33848919&form=6&db=m Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin. causal interaction,unassigned 2,0 3.4.17.23 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33975613&form=6&db=m COVID-19 and periodontitis: reflecting on a possible association. causal interaction,unassigned 1,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29506841&form=6&db=m Impact of angiotensin-converting enzyme 2 levels on postoperative pneumonia after esophagectomy. therapeutic application,unassigned 2,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32285293&form=6&db=m Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV. therapeutic application,unassigned 3,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584474&form=6&db=m A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32907637&form=6&db=m COVID-19: an update and cardiac involvement. causal interaction,unassigned 4,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049279&form=6&db=m Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33146121&form=6&db=m Case Report: Ischemic Colitis in Severe COVID-19 Pneumonia: An Unforeseen Gastrointestinal Complication. causal interaction,unassigned 2,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159236&form=6&db=m Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347477&form=6&db=m Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33598195&form=6&db=m Alternative antibiotic feed additives alleviate pneumonia with inhibiting ACE-2 expression in the respiratory system of piglets. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681293&form=6&db=m Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted. ongoing research,unassigned 3,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073591&form=6&db=m Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34156696&form=6&db=m Analysis of the involvement of the thyroid gland using computed tomography in patients with suspected SARS-CoV-2 infection: a retrospective study. unassigned - 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34171587&form=6&db=m SARS-CoV-2 and helminth co-infections, and environmental pollution exposure: An epidemiological and immunological perspective. causal interaction,unassigned 4,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258966&form=6&db=m Effects of Smoking on ACE2 Expression Pattern: Risk and Severity of SARS-CoV-2 Infection. causal interaction,unassigned 4,0 3.4.17.23 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341671&form=6&db=m COVID-19 post-mortem findings: how the departed can teach us. unassigned - 3.4.17.23 Pneumonia, Viral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33468263&form=6&db=m Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2. causal interaction,unassigned 4,0 3.4.17.23 Pneumonia, Viral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33639976&form=6&db=m Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Post-Exercise Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27925380&form=6&db=m Angiotensin converting enzyme 2 polymorphisms and postexercise hypotension in hypertensive medicated individuals. causal interaction,unassigned 2,0 3.4.17.23 Postural Orthostatic Tachycardia Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289653&form=6&db=m Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome. unassigned - 3.4.17.23 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32853537&form=6&db=m Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33101066&form=6&db=m Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age. diagnostic usage,unassigned 2,0 3.4.17.23 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33129880&form=6&db=m Is highly expressed ACE 2 in pregnant women "a curse" in times of COVID-19 pandemic? causal interaction,unassigned 3,0 3.4.17.23 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34093245&form=6&db=m Corrigendum: Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age. diagnostic usage,unassigned 2,0 3.4.17.23 Prehypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089050&form=6&db=m Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes? causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3 3.4.17.23 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32853537&form=6&db=m Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Primary Dysautonomias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33705614&form=6&db=m Characterization of cardiac autonomic function in COVID-19 using heart rate variability: a hospital based preliminary observational study. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19597533&form=6&db=m Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745466&form=6&db=m The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.17.23 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338334&form=6&db=m The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24512523&form=6&db=m Diagnostic and prognostic scoring system for prostate cancer using urine and plasma biomarkers. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.17.23 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736744&form=6&db=m Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485450&form=6&db=m Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245484&form=6&db=m Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745466&form=6&db=m The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15537383&form=6&db=m The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16254181&form=6&db=m Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16575200&form=6&db=m ETS-TMPRSS2 Fusion Gene Products in Prostate Cancer. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585160&form=6&db=m TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. ongoing research,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951139&form=6&db=m TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951141&form=6&db=m Expression of Variant TMPRSS2/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17021644&form=6&db=m Prevention, complementary therapies, and new scientific developments in the field of prostate cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17059688&form=6&db=m Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer. ongoing research,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079440&form=6&db=m TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108102&form=6&db=m TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17172822&form=6&db=m Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17334343&form=6&db=m Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17334351&form=6&db=m A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17390040&form=6&db=m Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17401460&form=6&db=m Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17414513&form=6&db=m Prostate cancer prevention. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488563&form=6&db=m Morphological features of TMPRSS2: ERG fusion prostate cancer. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17494120&form=6&db=m Re: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505060&form=6&db=m ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17632455&form=6&db=m Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17637754&form=6&db=m Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17654723&form=6&db=m Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671502&form=6&db=m Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. ongoing research,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17679089&form=6&db=m A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17826677&form=6&db=m TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE, Cao X, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI. ongoing research,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971772&form=6&db=m Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18165275&form=6&db=m Detection of TMPRSS2-ERG translocations in human prostate cancer by expression profiling using GeneChip Human Exon 1.0 ST arrays. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18240415&form=6&db=m Words of wisdom. Re: duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338334&form=6&db=m The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408932&form=6&db=m What is the molecular pathology of low-risk prostate cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18451133&form=6&db=m Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18483239&form=6&db=m Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18642766&form=6&db=m [Frequency and transcript variant analysis of gene fusions between TMPRSS2 and ETS transcription factor genes in prostate cancer] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18654591&form=6&db=m A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18781147&form=6&db=m Fusion in the ETS gene family and prostate cancer. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18798265&form=6&db=m Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066166&form=6&db=m Hormone-sensitive prostate cancer: a case of ETS gene fusion heterogeneity. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147579&form=6&db=m Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19176386&form=6&db=m Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. therapeutic application,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19190343&form=6&db=m TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19205910&form=6&db=m Genetic variation in the upstream region of ERG and prostate cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19212347&form=6&db=m ETS rearrangements and prostate cancer initiation. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19242826&form=6&db=m Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19297326&form=6&db=m Inhibition of tumor cell motility by the interferon-inducible GTPase MxA. causal interaction,unassigned 4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19339269&form=6&db=m Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19399032&form=6&db=m TMPRSS2-ERG and PTEN loss in prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409690&form=6&db=m ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical Practice. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19520778&form=6&db=m Epigenetic alterations in human prostate cancers. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584163&form=6&db=m Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States. causal interaction,unassigned 4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19647299&form=6&db=m Detection of TMPRSS2-ERG Fusion Gene Expression in Prostate Cancer Specimens by a Novel Assay Using Branched DNA. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19649210&form=6&db=m N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664128&form=6&db=m TMPRSS2:ERG fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosis. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19716227&form=6&db=m Expression of the Androgen-Regulated Fusion Gene TMPRSS2-ERG Does Not Predict Response to Endocrine Treatment in Hormone-Naïve, Node-Positive Prostate Cancer. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825963&form=6&db=m Overexpression of Prostate-Specific TMPRSS2(exon 0)-ERG Fusion Transcripts Corresponds with Favorable Prognosis of Prostate Cancer. diagnostic usage,unassigned 4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861517&form=6&db=m Predisposition for TMPRSS2-ERG Fusion in Prostate Cancer by Variants in DNA Repair Genes. causal interaction,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19933109&form=6&db=m Induced chromosomal proximity and gene fusions in prostate cancer. ongoing research,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956446&form=6&db=m ETS gene fusions and prostate cancer. ongoing research,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20014889&form=6&db=m Emerging biological observations in prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118910&form=6&db=m Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20147525&form=6&db=m 1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20303538&form=6&db=m Clinical implications of TMPRSS2-ERG gene fusion expression in patients with prostate cancer treated with radical prostatectomy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382709&form=6&db=m TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells. causal interaction,ongoing research,unassigned 3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20473283&form=6&db=m ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20478527&form=6&db=m An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20534728&form=6&db=m 3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20563261&form=6&db=m Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20735386&form=6&db=m Racial differences in prediction of time to prostate cancer diagnosis in a prospective screening cohort of high-risk men: effect of TMPRSS2 Met160Val. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736744&form=6&db=m Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20947519&form=6&db=m Androgen-induced TMPRSS2:ERG fusion in non-malignant prostate epithelial cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21036922&form=6&db=m Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing. ongoing research,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21169414&form=6&db=m Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21519790&form=6&db=m Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575391&form=6&db=m [Detection and significance of fusion gene between TMPRSS2 and ETS transcription factor genes in fresh prostatic cancer tissues in Chinese patients]. ongoing research,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21747944&form=6&db=m TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21796535&form=6&db=m Androgen Regulation of ETS Gene Fusion Transcripts in Prostate Cancer. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946329&form=6&db=m A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21969603&form=6&db=m Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells. ongoing research,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22415461&form=6&db=m Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22452941&form=6&db=m Correlation of ERG expression and DNA methylation biomarkers with adverse clinicopathologic features of prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22767266&form=6&db=m ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer. causal interaction,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22821757&form=6&db=m Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22860005&form=6&db=m TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation. ongoing research,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22899295&form=6&db=m Marked heterogeneity of ERG expression in large primary prostate cancers. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23052253&form=6&db=m Highly specific targeting of the TMPRSS2/ERG fusion gene using liposomal nanovectors. therapeutic application,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23192983&form=6&db=m Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. diagnostic usage,therapeutic application,unassigned 3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23244085&form=6&db=m Fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers from northern China. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23264855&form=6&db=m TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer Progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23272087&form=6&db=m Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23352841&form=6&db=m A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357671&form=6&db=m Truncated ERG proteins affect the aggressiveness of prostate cancer. causal interaction,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384557&form=6&db=m The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426182&form=6&db=m ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23447416&form=6&db=m Base pair resolution analysis of TMPRSS2-ERG rearrangements in prostate cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23459095&form=6&db=m A high-density tissue microarray from patients with clinically localized prostate cancer reveals ERG and TATI exclusivity in tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23472063&form=6&db=m 5' UTR Control of Native ERG and of Tmprss2:ERG Variants Activity in Prostate Cancer. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23535644&form=6&db=m Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23661613&form=6&db=m Immunohistochemical expression of ERG in the molecular epidemiology of fatal prostate cancer study. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23728339&form=6&db=m miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT. diagnostic usage,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23913826&form=6&db=m ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23974730&form=6&db=m The end of the road for prostate specific antigen testing? causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24109594&form=6&db=m Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24115221&form=6&db=m Evaluation of ERG responsive proteome in prostate cancer. causal interaction,unassigned 4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142545&form=6&db=m Evaluation of the TMPRSS2:ERG fusion for the detection of prostate cancer: a systematic review and meta-analysis. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24149465&form=6&db=m Development of a peptide-based vaccine targeting TMPRSS2:ERG fusion-positive prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24418414&form=6&db=m Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24488012&form=6&db=m Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659477&form=6&db=m ETS fusion genes in prostate cancer. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24764242&form=6&db=m Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25007891&form=6&db=m The role of TMPRSS2:ERG in molecular stratification of PCa and its association with tumor aggressiveness: a study in Brazilian patients. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25040002&form=6&db=m TMPRSS2 Met160Val polymorphism: Significant association with sporadic prostate cancer, but not with latent prostate cancer in Japanese men. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25079439&form=6&db=m Comparative evaluation of urinary PCA3 and TMPRSS2: ERG scores and serum PHI in predicting prostate cancer aggressiveness. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122198&form=6&db=m The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25170998&form=6&db=m ERG monoclonal antibody in the diagnosis and biological stratification of prostate cancer: delineation of minimal epitope, critical residues for binding, and molecular basis of specificity. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25179500&form=6&db=m Prostate cancer: TMPRSS2 promotes metastasis through proteolysis. causal interaction,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25221645&form=6&db=m Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520876&form=6&db=m Involvement of different mechanisms for the association of CAG repeat length polymorphism in androgen receptor gene with prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25563374&form=6&db=m Prognostic and predictive molecular biological markers in prostate cancer - significance of expression of genes PCA3 and TMPRSS2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25679011&form=6&db=m Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in Ets Related Gene-Positive Prostate Cancers. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25745638&form=6&db=m Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25780911&form=6&db=m Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25899828&form=6&db=m Weaker ERG expression in patients with ERG-positive prostate cancer is associated with advanced disease and weaker androgen receptor expression: An Indian outlook. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25969144&form=6&db=m miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25977336&form=6&db=m NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26018085&form=6&db=m Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26344095&form=6&db=m SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26665675&form=6&db=m [Relationship between TMPRSS2: ERG and the pathological grade of prostate cancer]. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774207&form=6&db=m Urine TMPRSS2: ERG Fusion Transcript as a Biomarker for Prostate Cancer: Literature Review. diagnostic usage,therapeutic application,unassigned 4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26837907&form=6&db=m Molecular Pathology of the Genitourinary Tract: Prostate and Bladder. causal interaction,diagnostic usage,unassigned 2,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26880803&form=6&db=m Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26935606&form=6&db=m Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin?induced cell death. causal interaction,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27144529&form=6&db=m Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27375789&form=6&db=m Colorimetric TMPRSS2-ERG Gene Fusion Detection in Prostate Cancer Urinary Samples via Recombinase Polymerase Amplification. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27536883&form=6&db=m A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27926866&form=6&db=m Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28382513&form=6&db=m RNA splicing and splicing regulator changes in prostate cancer pathology. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849022&form=6&db=m Significance of the TMPRSS2:ERG gene fusion in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786791&form=6&db=m Protocols for Studies on TMPRSS2/ERG in Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30076933&form=6&db=m MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells. diagnostic usage,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30078722&form=6&db=m Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367117&form=6&db=m Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer. unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30505817&form=6&db=m Status of TMPRSS2-ERG fusion in prostate cancer patients from India: correlation with clinico-pathological details and TMPRSS2 Met160Val polymorphism. ongoing research,unassigned 1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656528&form=6&db=m Prostatic adenocarcinoma CNS parenchymal and dural metastases: alterations in ERG, CHD1 and MAP3K7 expression. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30680235&form=6&db=m Association between TMPRSS2:ERG fusion gene and the prostate cancer: systematic review and meta-analysis. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30892142&form=6&db=m The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31097763&form=6&db=m Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366128&form=6&db=m Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31405024&form=6&db=m Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer. causal interaction,unassigned 2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276929&form=6&db=m TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32387456&form=6&db=m Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32412310&form=6&db=m The management of patients with metastatic prostate cancer during the COVID-19 pandemic. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508311&form=6&db=m COVID-19 and androgen-targeted therapy for prostate cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32658591&form=6&db=m The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32677026&form=6&db=m Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32778768&form=6&db=m Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32873700&form=6&db=m Gene of the month: TMPRSS2 (transmembrane serine protease 2). unassigned - 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32897764&form=6&db=m Androgen Deprivation Therapy in Men With Prostate Cancer Does Not Affect Risk of Infection With SARS-CoV-2. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32978525&form=6&db=m KLK3 and TMPRSS2 for molecular lymph-node staging in prostate cancer patients undergoing radical prostatectomy. diagnostic usage,therapeutic application,unassigned 3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33278516&form=6&db=m ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,3 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33301988&form=6&db=m Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33303959&form=6&db=m Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease. diagnostic usage,unassigned 3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33415017&form=6&db=m Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609069&form=6&db=m Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33627383&form=6&db=m Association of pre-diagnostic blood metabolomics with prostate cancer defined by ERG or PTEN molecular subtypes. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754609&form=6&db=m Effects of COVID-19 on male sex function and its potential sexual transmission. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791156&form=6&db=m Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089595&form=6&db=m Do Anti-androgens Have Potential as Therapeutics for COVID-19? causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34225789&form=6&db=m Hormonal intervention for the treatment of veterans with COVID-19 requiring hospitalization (HITCH): a multicenter, phase 2 randomized controlled trial of best supportive care vs best supportive care plus degarelix: study protocol for a randomized controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.17.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34420994&form=6&db=m The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28501298&form=6&db=m ACE2 as therapy for glomerular disease: the devil is in the detail. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30514826&form=6&db=m Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome. therapeutic application,unassigned 3,0 3.4.17.23 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080435&form=6&db=m The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486379&form=6&db=m A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection? diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.17.23 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382146&form=6&db=m Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613639&form=6&db=m Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23095677&form=6&db=m Propofol increases angiotensin-converting enzyme 2 expression in human pulmonary artery endothelial cells. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548773&form=6&db=m The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23652350&form=6&db=m ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29146157&form=6&db=m Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29903860&form=6&db=m A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30806090&form=6&db=m Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32241831&form=6&db=m Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755395&form=6&db=m MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24417403&form=6&db=m Angiotensin-converting enzyme-2 overexpression attenuates inflammation in rat model of chronic obstructive pulmonary disease. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29100503&form=6&db=m Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29490639&form=6&db=m Commenting on "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues. ongoing research,unassigned 2,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29733687&form=6&db=m Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study. diagnostic usage,unassigned 3,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269089&form=6&db=m ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. diagnostic usage,unassigned 2,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32537478&form=6&db=m Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32587985&form=6&db=m Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis. causal interaction,unassigned 2,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32702724&form=6&db=m Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis. causal interaction,unassigned 2,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33013423&form=6&db=m Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. causal interaction,unassigned 3,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112187&form=6&db=m Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19. ongoing research,therapeutic application,unassigned 3,3,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330864&form=6&db=m Paradoxical effects of cigarette smoke and COPD on SARS-CoV2 infection and disease. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33425965&form=6&db=m Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells. causal interaction,unassigned 1,0 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33978304&form=6&db=m Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.17.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305888&form=6&db=m Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178794&form=6&db=m The Reasons for Higher Mortality Rate in Opium Addicted Patients with COVID-19: A Narrative Review. causal interaction,unassigned 3,0 3.4.17.23 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784777&form=6&db=m RhoA-Rho associated kinase signaling leads to renin-angiotensin system imbalance and angiotensin converting enzyme 2 has a protective role in acute pulmonary embolism. causal interaction,unassigned 3,0 3.4.17.23 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19246717&form=6&db=m Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25089563&form=6&db=m The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822530&form=6&db=m Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats. causal interaction,unassigned 4,0 3.4.17.23 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30175235&form=6&db=m The renin angiotensin system in liver and lung: impact and therapeutic potential in organ fibrosis. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706759&form=6&db=m Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34047940&form=6&db=m COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential development. ongoing research,unassigned 3,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23535224&form=6&db=m Angiotensin-converting enzyme 2 activity in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23951161&form=6&db=m Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury. ongoing research,therapeutic application,unassigned 3,2,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24004970&form=6&db=m Intrarenal Distributions and Changes of Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 in Feline and Canine Chronic Kidney Disease. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25813276&form=6&db=m Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27220756&form=6&db=m Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27615597&form=6&db=m Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28186543&form=6&db=m Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30326474&form=6&db=m Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089050&form=6&db=m Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes? causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080435&form=6&db=m The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33125431&form=6&db=m Kidney ACE2 expression: Implications for chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413390&form=6&db=m Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24331807&form=6&db=m [Angiotensin-converting enzyme 2 gene transfer attenuates neointimal formation after carotid artery ischemia-reperfusion injury in rats]. ongoing research,unassigned 4,0 3.4.17.23 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25230251&form=6&db=m The functional study of human umbilical cord mesenchymal stem cells harbouring angiotensin-converting enzyme 2 in rat acute lung ischemia-reperfusion injury model. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25756848&form=6&db=m Combination therapy with human umbilical cord mesenchymal stem cells and angiotensin-converting enzyme 2 is superior for the treatment of acute lung ischemia-reperfusion injury in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.4.17.23 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437004&form=6&db=m Hepatic complications of COVID-19 and its treatment. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17558469&form=6&db=m Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. causal interaction,unassigned 2,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18340998&form=6&db=m [Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)] causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851091&form=6&db=m Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24226567&form=6&db=m Imbalance between pulmonary angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in acute respiratory distress syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28877748&form=6&db=m A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32250244&form=6&db=m Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32561317&form=6&db=m Pharmacovigilance in patients with diabetes: A data-driven analysis identifying specific RAS antagonists with adverse pulmonary safety profiles that have implications for COVID-19 morbidity and mortality. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584199&form=6&db=m Human and novel coronavirus infections in children: a review. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32597377&form=6&db=m The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,3 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32926920&form=6&db=m New insights on possible vaccine development against SARS-CoV-2. ongoing research,unassigned 1,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973534&form=6&db=m Research Progress of Genetic Structure, Pathogenic Mechanism, Clinical Characteristics, and Potential Treatments of Coronavirus Disease 2019. diagnostic usage,unassigned 3,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049279&form=6&db=m Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417604&form=6&db=m Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2). causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33958841&form=6&db=m Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34189703&form=6&db=m Effects of Recombinant Human Angiotensin-Converting Enzyme 2 on Response to Acute Hypoxia and Exercise: A Randomised, Placebo-Controlled Study. causal interaction,unassigned 3,0 3.4.17.23 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34358119&form=6&db=m Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 3.4.17.23 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18490652&form=6&db=m Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry. causal interaction,unassigned 3,0 3.4.17.23 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32250244&form=6&db=m Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33302976&form=6&db=m Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33563197&form=6&db=m The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33935396&form=6&db=m Acute Kidney Injury in COVID-19: a Brief Review. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142828&form=6&db=m Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33688035&form=6&db=m One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection. ongoing research,therapeutic application,unassigned 3,2,0 3.4.17.23 Rheumatic Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422146&form=6&db=m Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.17.23 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16315782&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20473283&form=6&db=m ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.17.23 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32629817&form=6&db=m Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194496&form=6&db=m Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15221932&form=6&db=m Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15241071&form=6&db=m Severe acute respiratory syndrome: an update. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15367630&form=6&db=m Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15452268&form=6&db=m Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492138&form=6&db=m Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15496474&form=6&db=m CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16033974&form=6&db=m Vesicular stomatitis virus pseudotyped with severe acute respiratory syndrome coronavirus spike protein. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16261211&form=6&db=m [Cloning of ACE-2 gene encoding the functional receptor for the SARS coronavirus and its expression in eukaryotic cells] diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597622&form=6&db=m Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16772384&form=6&db=m Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912312&form=6&db=m Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108019&form=6&db=m Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. causal interaction,ongoing research,unassigned 1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553448&form=6&db=m The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565868&form=6&db=m [Expression of severe acute respiratory syndrome coronavirus receptors, ACE2 and CD209L in different organ derived microvascular endothelial cells] diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652383&form=6&db=m Amino acid substitutions in the s2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17673668&form=6&db=m Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974127&form=6&db=m Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18077725&form=6&db=m Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199653&form=6&db=m Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18310257&form=6&db=m Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18343844&form=6&db=m Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18801550&form=6&db=m Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19297479&form=6&db=m Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19453650&form=6&db=m SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625462&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20926566&form=6&db=m Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21068237&form=6&db=m A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21563828&form=6&db=m Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22496216&form=6&db=m Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22718567&form=6&db=m Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23572553&form=6&db=m The emergence of human coronavirus EMC: how scared should we be? unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24227843&form=6&db=m TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25187545&form=6&db=m Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379044&form=6&db=m TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27733646&form=6&db=m Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572566&form=6&db=m SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus). ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075877&form=6&db=m Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32200663&form=6&db=m COVID-19 and Cardiovascular Disease. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32215613&form=6&db=m Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32273490&form=6&db=m Coronavirus Disease 2019 (COVID-19) in Children - What We Know So Far and What We Do Not. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32283711&form=6&db=m scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. diagnostic usage,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32290680&form=6&db=m Severe acute respiratory syndrome coronavirus 2 infection, angiotensin-converting enzyme 2 and treatment with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32301766&form=6&db=m Cardiovascular Pharmacology in the Time of COVID-19: A Focus on Angiotensin-Converting Enzyme 2. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32306452&form=6&db=m Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: A double-edged sword? causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32310688&form=6&db=m Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32323565&form=6&db=m Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19? causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32333222&form=6&db=m The genetic sequence, origin, and diagnosis of SARS-CoV-2. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32333836&form=6&db=m Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32335367&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32351121&form=6&db=m Evidence for Use or Disuse of Renin-Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32361098&form=6&db=m Does infection of 2019 novel coronavirus cause acute and/or chronic sialadenitis? causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32387456&form=6&db=m Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32391742&form=6&db=m Abdominal Imaging Findings in COVID-19: Preliminary Observations. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393136&form=6&db=m Coronavirus Disease 2019 and the Cerebrovascular-Cardiovascular Systems: What Do We Know So Far? causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32404898&form=6&db=m Diabetes and COVID-19: evidence, current status and unanswered research questions. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32407491&form=6&db=m iBioProVis: interactive visualization and analysis of compound bioactivity space. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32409434&form=6&db=m Renin-angiotensin system inhibitors in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32412156&form=6&db=m COVID-19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease. ongoing research,therapeutic application,unassigned 4,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418199&form=6&db=m Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422280&form=6&db=m Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422996&form=6&db=m Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428380&form=6&db=m Increased ACE2 Expression in Bronchial Epithelium of COPD Patients who are Overweight. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32432918&form=6&db=m Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437004&form=6&db=m Hepatic complications of COVID-19 and its treatment. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32437244&form=6&db=m Let's talk about sex in the context of COVID-19. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32439197&form=6&db=m COVID-19 and Multiorgan Response. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32444876&form=6&db=m Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32446267&form=6&db=m What solid organ transplant healthcare providers should know about renin-angiotensin-aldosterone system inhibitors and COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450906&form=6&db=m Impact of sex and gender on COVID-19 outcomes in Europe. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482249&form=6&db=m No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497637&form=6&db=m Analysis of Gastrointestinal and Hepatic Manifestations of SARS-CoV-2 Infection in 892 Patients in Queens, NY. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32498696&form=6&db=m COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32503918&form=6&db=m Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions. diagnostic usage,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32510598&form=6&db=m Single-cell RNA analysis on ACE2 expression provides insights into SARS-CoV-2 potential entry into the bloodstream and heart injury. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32525548&form=6&db=m Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32527987&form=6&db=m Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32532094&form=6&db=m The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32537478&form=6&db=m Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550040&form=6&db=m Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32558150&form=6&db=m Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32562137&form=6&db=m Air contamination with SARS-CoV-2 in the operating room. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32574271&form=6&db=m The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32584199&form=6&db=m Human and novel coronavirus infections in children: a review. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32595762&form=6&db=m Involvement of digestive system in COVID-19: manifestations, pathology, management and challenges. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32598305&form=6&db=m Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)? causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32602627&form=6&db=m Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32622449&form=6&db=m Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32623546&form=6&db=m Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32629204&form=6&db=m A hypothesis on the role of the human immune system in covid-19. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633594&form=6&db=m Could Anti-Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID-19 Infection? Data From Centers of Southern Italy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32635188&form=6&db=m Analysis of ACE2 Genetic Variability among Populations Highlights a Possible Link with COVID-19-Related Neurological Complications. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32635289&form=6&db=m ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32636754&form=6&db=m A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32637954&form=6&db=m Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32639848&form=6&db=m The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32639866&form=6&db=m Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652001&form=6&db=m Endocrine Significance of SARS-CoV-2's Reliance on ACE2. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655724&form=6&db=m Coronavirus Disease 2019: A Gastroenterologist's Perspective in May 2020. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32665962&form=6&db=m The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32670680&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Induced Cardiovascular Syndrome: Etiology, Outcomes, and Management. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32673940&form=6&db=m EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675312&form=6&db=m ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32690544&form=6&db=m Genetic variations in the human severe acute respiratory syndrome coronavirus receptor ACE2 and serine protease TMPRSS2. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32690910&form=6&db=m COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32695320&form=6&db=m A brand-new cardiorenal syndrome in the COVID-19  setting. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32695327&form=6&db=m Coronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injury. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32697597&form=6&db=m Is there an association between the level of ambient air pollution and COVID-19? causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32700671&form=6&db=m Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32710575&form=6&db=m Angiotensin converting enzyme 2 at the interface between renin-angiotensin system inhibition and coronavirus disease 2019. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32735992&form=6&db=m Design of an engineered ACE2 as a novel therapeutics against COVID-19. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32736307&form=6&db=m The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19). ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32743577&form=6&db=m Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32745604&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32753553&form=6&db=m Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32768580&form=6&db=m Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32778631&form=6&db=m The Role of Chest Radiograph, Procalcitonin and Moxifloxacin in Diagnosis and Management of Breast Cancer Patients with COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32783758&form=6&db=m ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32785086&form=6&db=m Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32785121&form=6&db=m Key Aspects in Nutritional Management of COVID-19 Patients. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793909&form=6&db=m mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32824674&form=6&db=m Sex Hormones and Hormone Therapy during COVID-19 Pandemic: Implications for Patients with Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32824830&form=6&db=m ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825469&form=6&db=m Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32826753&form=6&db=m Clinical significance of angiotensin-converting enzyme 2 receptors for severe acute respiratory syndrome coronavirus 2 (COVID-19) on peripheral small-fiber sensory neurons is unknown today. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32831104&form=6&db=m Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2). causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32834893&form=6&db=m Does hereditary angioedema make COVID-19 worse? unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835160&form=6&db=m The interaction between the endocannabinoid system and the renin angiotensin system and its potential implication for COVID-19 infection. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32837754&form=6&db=m SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal-Fetal Interface. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32839779&form=6&db=m Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity. therapeutic application,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32840758&form=6&db=m SARS-CoV-2 Infectivity and Neurological Targets in the Brain. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32853537&form=6&db=m Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia. causal interaction,ongoing research,unassigned 4,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863157&form=6&db=m Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32879112&form=6&db=m Potential pathogenesis of severe acute respiratory syndrome coronavirus 2. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32888876&form=6&db=m Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32902940&form=6&db=m Severe acute respiratory syndrome coronavirus-2 and the deduction effect of angiotensin-converting enzyme 2 in pregnancy. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32907637&form=6&db=m COVID-19: an update and cardiac involvement. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908985&form=6&db=m Angiotensin converting enzyme 2 is a novel target of the ?-secretase complex. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909725&form=6&db=m Hypernatremia-A Manifestation of COVID-19: A Case Series. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32912711&form=6&db=m COVID-19 and diabetes; Possible role of polymorphism and rise of telemedicine. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917504&form=6&db=m Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32931734&form=6&db=m A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32935109&form=6&db=m Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32935928&form=6&db=m Crosstalk between coronavirus disease 2019 and cardiovascular disease and its treatment. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32937949&form=6&db=m Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942748&form=6&db=m SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System? causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32950735&form=6&db=m Linking ACE2 and angiotensin II to pulmonary immunovascular dysregulation in SARS-CoV-2 infection. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32963099&form=6&db=m In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32964684&form=6&db=m The overlooked chamber in coronavirus disease 2019. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968645&form=6&db=m Pulmonary vascular endothelial injury and acute pulmonary hypertension caused by COVID-19: the fundamental cause of refractory hypoxemia? causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32981023&form=6&db=m A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982622&form=6&db=m Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32990980&form=6&db=m The Possible Double-Edged Sword Effects of Vitamin D on COVID-19: A Hypothesis. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991738&form=6&db=m Overexpression of the SARS-CoV-2 receptor ACE2 is induced by cigarette smoke in bronchial and alveolar epithelia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995775&form=6&db=m Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein's Receptor Binding Domain and Recombinant Human ACE2. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32996784&form=6&db=m Sex steroids skew ACE2 expression in human airway: A contributing factor to sex differences in COVID-19? diagnostic usage,ongoing research,unassigned 1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33013423&form=6&db=m Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014653&form=6&db=m Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33025652&form=6&db=m Using genetics to understand the role of antihypertensive drugs modulating angiotensin-converting enzyme in immune function and inflammation. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33029419&form=6&db=m Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)? causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33032170&form=6&db=m SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33034780&form=6&db=m Drug screening and development from the affinity of S protein of new coronavirus with ACE2. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043048&form=6&db=m Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043050&form=6&db=m Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043967&form=6&db=m Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33045350&form=6&db=m Azithromycin and ambroxol as potential pharmacotherapy for SARS-CoV-2. causal interaction,therapeutic application,unassigned 2,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052333&form=6&db=m SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052346&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057007&form=6&db=m ACE2 mouse models: a toolbox for cardiovascular and pulmonary research. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059040&form=6&db=m Benign Evolution of SARS-Cov2 Infections in Children With Inflammatory Bowel Disease: Results From Two International Databases. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059811&form=6&db=m [Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33067518&form=6&db=m Quantifying the adhesive strength between the SARS-CoV-2 S-proteins and human receptor and its effect in therapeutics. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33073064&form=6&db=m Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33075345&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33077915&form=6&db=m Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33077916&form=6&db=m Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor. causal interaction,ongoing research,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33085491&form=6&db=m Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33091758&form=6&db=m The role of androgens in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33101175&form=6&db=m SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33123616&form=6&db=m The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33125431&form=6&db=m Kidney ACE2 expression: Implications for chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33128130&form=6&db=m Central Nervous System Manifestations Associated with COVID-19. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33130103&form=6&db=m The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33139905&form=6&db=m Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33143053&form=6&db=m miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33148439&form=6&db=m Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152165&form=6&db=m Effects of SARS-CoV-2 infection on male sex-related hormones in recovering patients. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33153216&form=6&db=m Novel Evidence of Acute Kidney Injury in COVID-19. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33153403&form=6&db=m Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection? causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33154106&form=6&db=m An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33154107&form=6&db=m De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33154233&form=6&db=m Paediatric COVID-19 and the GUT. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159417&form=6&db=m Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33160965&form=6&db=m Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33173592&form=6&db=m A Hydrophobic-Interaction-Based Mechanism Triggers Docking between the SARS-CoV-2 Spike and Angiotensin-Converting Enzyme 2. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33178033&form=6&db=m Physical Exercise and the Renin Angiotensin System: Prospects in the COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33179911&form=6&db=m Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186231&form=6&db=m Structural basis of severe acute respiratory syndrome coronavirus 2 infection. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33189680&form=6&db=m The flexibility of ACE2 in the context of SARS-CoV-2 infection. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33191600&form=6&db=m Renin-angiotensin system inhibition and risk of infection and mortality in COVID-19: a systematic review and meta-analysis. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193639&form=6&db=m Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33202598&form=6&db=m The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33202948&form=6&db=m Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33203141&form=6&db=m The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19. ongoing research,therapeutic application,unassigned 2,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33206176&form=6&db=m Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33209137&form=6&db=m Update on COVID-19: A teleconference with the Paediatric Virology Study Group (Review). causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33210623&form=6&db=m COVID-19: Current Understanding of Pathophysiology. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33210729&form=6&db=m Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33220921&form=6&db=m Functional importance of the D614G mutation in the SARS-CoV-2 spike protein. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33225308&form=6&db=m Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation. therapeutic application,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33228447&form=6&db=m Coronavirus Disease 2019-Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33232769&form=6&db=m SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33244168&form=6&db=m HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33249290&form=6&db=m A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33253796&form=6&db=m The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33269932&form=6&db=m Molecular Dynamics Reveals Complex Compensatory Effects of Ionic Strength on the Severe Acute Respiratory Syndrome Coronavirus 2 Spike/Human Angiotensin-Converting Enzyme 2 Interaction. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33274196&form=6&db=m Prognostic Significance of COVID-19 Receptor ACE2 and Recommendation for Antihypertensive Drug in Renal Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275999&form=6&db=m A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33290972&form=6&db=m In silico screening of potential anti-COVID-19 bioactive natural constituents from food sources by molecular docking. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292872&form=6&db=m The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33296096&form=6&db=m Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33303654&form=6&db=m A data-driven approach to identify risk profiles and protective drugs in COVID-19. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33307964&form=6&db=m Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers Use and COVID-19 Infection Among 824 650 Patients With Hypertension From a US Integrated Healthcare System. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310740&form=6&db=m Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker-Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310900&form=6&db=m Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33322198&form=6&db=m Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33323800&form=6&db=m Gene Expression of Angiotensin-Converting Enzyme 2 Receptor in Skin and the Implications for COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33326500&form=6&db=m mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33326798&form=6&db=m An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2. therapeutic application,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33330868&form=6&db=m Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33341894&form=6&db=m Potential benefits of dietary seaweeds as protection against COVID-19. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347477&form=6&db=m Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347649&form=6&db=m Usage of peptidases by SARS-CoV-2 and several human coronaviruses as receptors: A mysterious story. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358501&form=6&db=m Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33361716&form=6&db=m ACE2 role in SARS-CoV-2 infectivity and Covid-19 severity. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33374387&form=6&db=m Blocking Effect of Demethylzeylasteral on the Interaction between Human ACE2 Protein and SARS-CoV-2 RBD Protein Discovered Using SPR Technology. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33375616&form=6&db=m Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33386398&form=6&db=m SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33388749&form=6&db=m Distinct disease severity between children and older adults with COVID-19: Impacts of ACE2 expression, distribution, and lung progenitor cells. causal interaction,ongoing research,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33391794&form=6&db=m ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33395782&form=6&db=m New onset diabetes, type 1 diabetes and COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33399851&form=6&db=m Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33408744&form=6&db=m Hypertension and Electrolyte Disorders in Patients with COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33418950&form=6&db=m Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33421274&form=6&db=m Circulating cardiovascular microRNAs in critically ill COVID-19 patients. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33422505&form=6&db=m Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33426683&form=6&db=m Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33432247&form=6&db=m A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33434105&form=6&db=m SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450678&form=6&db=m Micronutrients and bioactive substances: Their potential roles in combating COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33462852&form=6&db=m ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469835&form=6&db=m Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470888&form=6&db=m Distribution of the ACE1 D Allele in the Bosnian-Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33471718&form=6&db=m Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33473054&form=6&db=m Thyroid complications of SARS and coronavirus disease 2019 (COVID-19). causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481336&form=6&db=m Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33492298&form=6&db=m COVID-19 and the Kidneys, Implications and Outcomes. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33495713&form=6&db=m The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33520309&form=6&db=m Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525682&form=6&db=m Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33532767&form=6&db=m Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33533060&form=6&db=m Isoelectric point determination by imaged CIEF of commercially available SARS-CoV-2 proteins and the hACE2 receptor. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542974&form=6&db=m Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33551947&form=6&db=m The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33554218&form=6&db=m Neuropathology of COVID-19 (neuro-COVID): clinicopathological update. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33566370&form=6&db=m A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33567524&form=6&db=m Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33585201&form=6&db=m Case Report: B Lymphocyte Disorders Under COVID-19 Inflammatory Pressure. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33591607&form=6&db=m Implications of SARS-CoV-2 infection for neurogastroenterology. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33607086&form=6&db=m Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33610551&form=6&db=m Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species. therapeutic application,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611416&form=6&db=m Severe acute respiratory syndrome coronavirus 2 infection, angiotensin-converting enzyme 2 and treatment with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611766&form=6&db=m Roux-en-Y Gastric Bypass Downregulates Angiotensin-Converting Enzyme 2 (ACE2) Gene Expression in Subcutaneous White Adipose Tissue: A Putative Protective Mechanism Against Severe COVID-19. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611884&form=6&db=m Use of Renin-Angiotensin-Aldosterone System Inhibitors and Severe COVID-19 Outcomes in Patients with Hypertension: A Nationwide Cohort Study. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33624300&form=6&db=m Akt-independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS-CoV2 infection. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33626084&form=6&db=m Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33638807&form=6&db=m MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33653891&form=6&db=m Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33654293&form=6&db=m Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33658066&form=6&db=m The important herbal pair for the treatment of COVID-19 and its possible mechanisms. therapeutic application,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660398&form=6&db=m Dual role for angiotensin-converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33681293&form=6&db=m Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684258&form=6&db=m Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684975&form=6&db=m A Comprehensive Review of COVID-19 Associated Neurological Manifestations. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33689337&form=6&db=m Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane. causal interaction,therapeutic application,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33692701&form=6&db=m Controversial Roles of the Renin Angiotensin System and Its Modulators During the COVID-19 Pandemic. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706067&form=6&db=m Why blood group A individuals are at risk whereas blood group O individuals are protected from SARS-CoV-2 (COVID-19) infection: A hypothesis regarding how the virus invades the human body via ABO(H) blood group-determining carbohydrates. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33712270&form=6&db=m Inpatient Omission of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Is Associated With Morbidity and Mortality in Coronavirus Disease 2019. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33714595&form=6&db=m Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33719829&form=6&db=m COVID-19 and human reproduction: A pandemic that packs a serious punch. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727353&form=6&db=m Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33731252&form=6&db=m Physiological implications of COVID-19 in reproduction: angiotensin-converting enzyme 2 a key player. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33737994&form=6&db=m What Do Influenza and COVID-19 Represent for Patients With Inflammatory Bowel Disease? causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33747178&form=6&db=m Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754082&form=6&db=m The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33755203&form=6&db=m ACE2 models of frequently contacted animals provide clues of their SARS-CoV-2 S protein affinity and viral susceptibility. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33758841&form=6&db=m A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33781826&form=6&db=m Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786714&form=6&db=m A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33796285&form=6&db=m Renin-angiotensin system blockade in the COVID-19 pandemic. causal interaction,ongoing research,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33801080&form=6&db=m Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806780&form=6&db=m Inappropriate Heart Rate Response to Hypotension in Critically Ill COVID-19-Associated Acute Kidney Injury. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33836016&form=6&db=m Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840836&form=6&db=m The identification of novel inhibitors of human angiotensin-converting enzyme 2 and main protease of Sars-Cov-2: A combination of in silico methods for treatment of COVID-19. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851521&form=6&db=m Short-term effects of COVID-19 on semen parameters: A multicenter study of 69 cases. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33852652&form=6&db=m Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19: A Review. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33853972&form=6&db=m Potential effects of COVID-19 on reproductive systems and fertility; assisted reproductive technology guidelines and considerations: a review. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33857754&form=6&db=m Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33865979&form=6&db=m The fight against COVID-19: Striking a balance in the renin-angiotensin system. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33869283&form=6&db=m A Multifunctional Peptide From Bacillus Fermented Soybean for Effective Inhibition of SARS-CoV-2 S1 Receptor Binding Domain and Modulation of Toll Like Receptor 4: A Molecular Docking Study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33870109&form=6&db=m Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33875979&form=6&db=m Classical and Counter-Regulatory Renin-Angiotensin System: Potential Key Roles in COVID-19 Pathophysiology. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33881142&form=6&db=m Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat? causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33885726&form=6&db=m Comparative phylogenetic analysis of SARS-CoV-2 spike protein-possibility effect on virus spillover. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893249&form=6&db=m Angiotensin-converting Enzyme 2 Specific Cell Subset Identification in Oral Tissues: A Need of the Hour in COVID-19 Research. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33911464&form=6&db=m COVID-19 and the gastrointestinal tract: Source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection? causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33918599&form=6&db=m The Spike Glycoprotein of SARS-CoV-2 Binds to ?1 Integrins Expressed on the Surface of Lung Epithelial Cells. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33926110&form=6&db=m Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33937568&form=6&db=m COVID-19 and bronchial asthma: current perspectives. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33949277&form=6&db=m Molecular docking of compounds from Clinacanthus nutans extract detected by GC-MS analysis with the SARS-CoV-2 main protease and ACE2 protein. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33957057&form=6&db=m The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33963249&form=6&db=m Angiotensin converting enzyme 2 is a novel target of the ?-secretase complex. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33965375&form=6&db=m The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33965680&form=6&db=m Intestinal expression of ACE2 in mice with high-fat diet-induced obesity and neonates exposed to maternal high-fat diet. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33968947&form=6&db=m Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33974910&form=6&db=m Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33975938&form=6&db=m An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33977847&form=6&db=m Computational and experimental insights on the interaction of artemisinin, dihydroartemisinin and chloroquine with SARS-CoV-2 spike protein receptor-binding domain (RBD). unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33979162&form=6&db=m Critical Interactions Between the SARS-CoV-2 Spike Glycoprotein and the Human ACE2 Receptor. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33980808&form=6&db=m The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33984310&form=6&db=m Computational optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995847&form=6&db=m Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33996911&form=6&db=m Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34000358&form=6&db=m Abnormal apelin-ACE2 and SGLT2 signaling contribute to adverse cardiorenal injury in patients with COVID-19. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34008647&form=6&db=m Antiviral drug design based on the opening mechanism of spike glycoprotein in SARS-CoV-2. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34015585&form=6&db=m COVID-19 and metabolic comorbidities: An update on emerging evidences for optimal therapies. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34018723&form=6&db=m NMR Based SARS-CoV-2 Antibody Screening. ongoing research,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34023987&form=6&db=m Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025115&form=6&db=m A review on SARS-CoV-2 and stroke pathogenesis and outcome. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34038630&form=6&db=m The COVID-19 pandemic, heart and cardiovascular diseases: What we have learned. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34048708&form=6&db=m SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34051791&form=6&db=m Dysregulation of COVID-19 related gene expression in the COPD lung. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34067683&form=6&db=m Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34079691&form=6&db=m Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients. causal interaction,ongoing research,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34083848&form=6&db=m A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19-Recovered Patients as a Probable Therapy for COVID-19. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34086837&form=6&db=m Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089595&form=6&db=m Do Anti-androgens Have Potential as Therapeutics for COVID-19? causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34097570&form=6&db=m A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34099979&form=6&db=m SARS-CoV-2 Viral Persistence Based on Cycle Threshold Value and Liver Injury in Patients With COVID-19. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102107&form=6&db=m Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131396&form=6&db=m Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34134991&form=6&db=m Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. ongoing research,therapeutic application,unassigned 2,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34137203&form=6&db=m Pulmonary ACE2 expression in neonatal and adult rats. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34138483&form=6&db=m Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34141782&form=6&db=m COVID-19 in gastroenterology and hepatology: Lessons learned and questions to be answered. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34146659&form=6&db=m TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34160836&form=6&db=m Male pituitary-gonadal axis dysfunction in post-acute COVID-19 syndrome-Prevalence and associated factors: A Mediterranean case series. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34166652&form=6&db=m TRP channels in COVID-19 disease: Potential targets for prevention and treatment. causal interaction,therapeutic application,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168732&form=6&db=m New perspectives on angiotensin-converting enzyme 2 and its related diseases. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34171382&form=6&db=m Zinc supplementation augments the suppressive effects of repurposed NF-?B inhibitors on ACE2 expression in human lung cell lines. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34174177&form=6&db=m Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177896&form=6&db=m Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178377&form=6&db=m The COVID-19 Menace. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178985&form=6&db=m SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal Tract. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179146&form=6&db=m SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179347&form=6&db=m Discovery of Small Anti-ACE2 Peptides to Inhibit SARS-CoV-2 Infectivity. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34185681&form=6&db=m AI-based spectroscopic monitoring of real-time interactions between SARS-CoV-2 and human ACE2. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34188005&form=6&db=m The interaction of the severe acute respiratory syndrome coronavirus 2 spike protein with drug-inhibited angiotensin converting enzyme 2 studied by molecular dynamics simulation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34196258&form=6&db=m Ibuprofen and COVID-19 disease: separating the myths from facts. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201505&form=6&db=m The Fight against COVID-19 on the Multi-Protease Front and Surroundings: Could an Early Therapeutic Approach with Repositioning Drugs Prevent the Disease Severity? causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214538&form=6&db=m Biophysical properties of the isolated spike protein binding helix of human ACE2. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34227468&form=6&db=m Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34227783&form=6&db=m Hypokalaemic Paralysis Associated with COVID-19 Infection. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230707&form=6&db=m Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection. ongoing research,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230799&form=6&db=m Angiotensin-converting enzyme 2 gene expression in human male urological tissues: implications for pathogenesis and virus transmission pathways. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249938&form=6&db=m The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer's Disease Pathology. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258316&form=6&db=m Prior Statin Use and Risk of Mortality and Severe Disease From Coronavirus Disease 2019: A Systematic Review and Meta-analysis. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34267664&form=6&db=m The Role of Pulmonary Surfactants in the Treatment of Acute Respiratory Distress Syndrome in COVID-19. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34274504&form=6&db=m Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34278995&form=6&db=m Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: A Forward-Looking Perspective. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34282405&form=6&db=m Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34282808&form=6&db=m Viral stimulation modulates endotype-related ACE2 expression in eosinophilic chronic rhinosinusitis. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34295715&form=6&db=m Coronavirus disease and the cardiovascular system: a narrative review of the mechanisms of injury and management implications. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34299289&form=6&db=m Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34300555&form=6&db=m Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated Biosensors. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305888&form=6&db=m Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307267&form=6&db=m Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical Review. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307596&form=6&db=m Role of gastrointestinal system on transmission and pathogenesis of SARS-CoV-2. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34308375&form=6&db=m ACE2 chromogenic immunostaining protocol optimized for formalin-fixed paraffin-embedded human tissue sections. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34340553&form=6&db=m The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34357998&form=6&db=m Cytokine-Induced Modulation of SARS-CoV2 Receptor Expression in Primary Human Nasal Epithelial Cells. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34359983&form=6&db=m SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain Signaling. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360989&form=6&db=m The Effects of A?1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367382&form=6&db=m IMAGING FINDINGS IN A CASE OF MYO-PERICARDITIS ASSOCIATED WITH SARS CoV-2 DISEASE. therapeutic application,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34371831&form=6&db=m Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats-Possible Implications for COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395561&form=6&db=m Case Report: An Unusual Case of Biventricular Thrombosis in a COVID-19 Patient With Ischemic Dilated Cardiomyopathy: Assessment of Mass Mobility and Embolic Risk by Tissue Doppler Imaging. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403732&form=6&db=m Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry. ongoing research,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407940&form=6&db=m Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413390&form=6&db=m Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34414260&form=6&db=m Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429799&form=6&db=m Ogilvie Syndrome and COVID-19 Infection. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433173&form=6&db=m Do SARS-CoV-2 Infection (COVID-19) and the Medications Administered for Its Treatment Impair Testicular Functions? causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433426&form=6&db=m Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System. causal interaction,unassigned 1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34442770&form=6&db=m The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review. causal interaction,therapeutic application,unassigned 3,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34444960&form=6&db=m Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445669&form=6&db=m "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry. ongoing research,unassigned 3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34451902&form=6&db=m Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34474710&form=6&db=m Effect of COVID-19 on hereditary angioedema activity and quality of life. causal interaction,unassigned 4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34490283&form=6&db=m Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497376&form=6&db=m Neutralizing antibodies for the prevention and treatment of COVID-19. unassigned - 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517429&form=6&db=m Influence of androgen deprivation therapy on the severity of COVID-19 in prostate cancer patients. causal interaction,unassigned 2,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520633&form=6&db=m Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID-19 Infections in Brazil. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34525378&form=6&db=m Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells. causal interaction,therapeutic application,unassigned 3,4,0 3.4.17.23 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34530046&form=6&db=m Comparison of SARS-CoV-2 variant lethality in human angiotensin-converting enzyme 2 transgenic mice. ongoing research,therapeutic application,unassigned 4,1,0 3.4.17.23 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616026&form=6&db=m Update on SARS-CoV-2 infection in children. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 3.4.17.23 Silicosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32368013&form=6&db=m ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica. causal interaction,unassigned 4,0 3.4.17.23 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32970391&form=6&db=m An investigation into the molecular basis of cancer comorbidities in coronavirus infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.17.23 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32432519&form=6&db=m Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)? ongoing research,unassigned 1,0 3.4.17.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32967703&form=6&db=m TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.17.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34160253&form=6&db=m Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat. therapeutic application,unassigned 4,0 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20117991&form=6&db=m [Relationship of angiotensin-converting enzyme 2 gene polymorphism with the prognosis of hypertensive stroke patients] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25941344&form=6&db=m Stages in Discovery: Angiotensin-Converting Enzyme Type 2 and Stroke. causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25941346&form=6&db=m Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27488276&form=6&db=m Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816157&form=6&db=m Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion. ongoing research,therapeutic application,unassigned 1,4,0 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513532&form=6&db=m Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke. causal interaction,therapeutic application,unassigned 4,3,0 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33521783&form=6&db=m Stroke in patients infected by the novel coronavirus and its causal mechanisms: A narrative review. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025115&form=6&db=m A review on SARS-CoV-2 and stroke pathogenesis and outcome. causal interaction,unassigned 3,0 3.4.17.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429796&form=6&db=m Large Vessel Stroke Following Multiple Other Strokes and Cardiomyopathy in a Forty-Nine-Year-Old COVID-19 Patient. causal interaction,unassigned 1,0 3.4.17.23 Superinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117175&form=6&db=m Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness? causal interaction,therapeutic application,unassigned 2,1,0 3.4.17.23 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289653&form=6&db=m Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome. unassigned - 3.4.17.23 Tachypnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32578794&form=6&db=m Sars-CoV-2: A clinical update - II. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.17.23 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844987&form=6&db=m Hemostatic abnormalities in COVID-19: A guided review. diagnostic usage,unassigned 2,0 3.4.17.23 Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34248940&form=6&db=m Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism. therapeutic application,unassigned 1,0 3.4.17.23 Thromboinflammation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844987&form=6&db=m Hemostatic abnormalities in COVID-19: A guided review. diagnostic usage,unassigned 2,0 3.4.17.23 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32874745&form=6&db=m Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0 3.4.17.23 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33334457&form=6&db=m Acute Kidney Injury in COVID-19: The Chinese Experience. causal interaction,unassigned 2,0 3.4.17.23 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33499680&form=6&db=m Obesity considerations during the COVID-19 outbreak. causal interaction,unassigned 4,0 3.4.17.23 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33909265&form=6&db=m Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives. causal interaction,unassigned 4,0 3.4.17.23 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34362133&form=6&db=m SARS-CoV-2 and Acute Cerebrovascular Events: An Overview. causal interaction,unassigned 4,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23093373&form=6&db=m The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases. therapeutic application,unassigned 2,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676883&form=6&db=m COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32887634&form=6&db=m SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32947927&form=6&db=m Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies. causal interaction,unassigned 4,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33118741&form=6&db=m COVID-19 - Endothelial Axis and Coronary Artery Bypass Graft Patency: a Target for Therapeutic Intervention? causal interaction,unassigned 4,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534131&form=6&db=m Potential mechanisms of cerebrovascular diseases in COVID-19 patients. causal interaction,unassigned 4,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33643747&form=6&db=m COVID-19 Encephalopathy in Adults. causal interaction,unassigned 3,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33725828&form=6&db=m Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports. therapeutic application,unassigned 1,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33802310&form=6&db=m Immunogenetic Predictors of Severe COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144749&form=6&db=m A review of acute limb ischemia in COVID-positive patients. causal interaction,unassigned 4,0 3.4.17.23 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258904&form=6&db=m Cardiac manifestations of COVID-19. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.17.23 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32970391&form=6&db=m An investigation into the molecular basis of cancer comorbidities in coronavirus infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.17.23 Thyroiditis, Subacute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33025553&form=6&db=m Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.17.23 Trypanosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26470648&form=6&db=m Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17851289&form=6&db=m Altered regulation of renin-angiotensin, endothelin and natriuretic peptide systems in rat kidney with chronic unilateral ureteral obstruction. diagnostic usage,unassigned 3,0 3.4.17.23 Urinary Bladder, Neurogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32648420&form=6&db=m Study of serum and urinary markers of the renin-angiotensin-aldosterone system in myelomeningocele patients with renal injury detected by DMSA. diagnostic usage,unassigned 2,0 3.4.17.23 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24854854&form=6&db=m Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25883526&form=6&db=m Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis. therapeutic application,unassigned 2,0 3.4.17.23 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27558087&form=6&db=m AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-?B and STAT3 Pathways. causal interaction,therapeutic application,unassigned 3,2,0 3.4.17.23 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29731719&form=6&db=m rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 3.4.17.23 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073591&form=6&db=m Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.17.23 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34375388&form=6&db=m Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.17.23 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33422990&form=6&db=m SARS-CoV-2 leads to a small vessel endotheliitis in the heart. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.17.23 Ventricular Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16908757&form=6&db=m Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,1 3.4.17.23 Ventricular Dysfunction, Left http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33029102&form=6&db=m The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.17.23 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821288&form=6&db=m Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants. diagnostic usage,unassigned 1,0 3.4.17.23 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851150&form=6&db=m Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants. diagnostic usage,unassigned 1,0 3.4.17.23 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34288726&form=6&db=m Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays. ongoing research,unassigned 4,0 3.4.17.23 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33108836&form=6&db=m Coronavirus Disease 2019 Transmission: Blood Viremia and Aerosol Generation from Spinal Surgery. Is There an Increased Risk to the Surgical Team? causal interaction,unassigned 3,0 3.4.17.23 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33351086&form=6&db=m Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. causal interaction,unassigned 2,0 3.4.17.23 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34248940&form=6&db=m Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism. therapeutic application,unassigned 1,0 3.4.17.23 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34534497&form=6&db=m An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy. causal interaction,unassigned 1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16306622&form=6&db=m Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. therapeutic application,unassigned 2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20926566&form=6&db=m Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21123387&form=6&db=m Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2. ongoing research,therapeutic application,unassigned 4,2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25203900&form=6&db=m Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26095298&form=6&db=m Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics. ongoing research,unassigned 2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276929&form=6&db=m TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348692&form=6&db=m COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32376987&form=6&db=m Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32423095&form=6&db=m The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32558946&form=6&db=m Distinct infection process of SARS-CoV-2 in human bronchial epithelial cells line. ongoing research,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32593740&form=6&db=m Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture. causal interaction,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32637965&form=6&db=m Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells. causal interaction,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32675206&form=6&db=m Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679589&form=6&db=m Supplementation with vitamin D in the COVID-19 pandemic? unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32740495&form=6&db=m Focus on clinical practice: angiotensin-converting enzyme 2 and corona virus disease 2019: pathophysiology and clinical implications. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32741970&form=6&db=m SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32743574&form=6&db=m Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2. ongoing research,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32839764&form=6&db=m Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2. causal interaction,ongoing research,unassigned 2,3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32844538&form=6&db=m Alpha-1-antitrypsin: A possible host protective factor against Covid-19. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32861070&form=6&db=m ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32924827&form=6&db=m Potential protease inhibitors and their combinations to block SARS-CoV-2. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32936429&form=6&db=m Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33002032&form=6&db=m In-silico design of a potential inhibitor of SARS-CoV-2 S protein. ongoing research,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33034780&form=6&db=m Drug screening and development from the affinity of S protein of new coronavirus with ACE2. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33052350&form=6&db=m Regulation of the ACE2 locus in human airways cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33123616&form=6&db=m The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33173871&form=6&db=m Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients. causal interaction,ongoing research,unassigned 4,3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33190109&form=6&db=m Cerebral Venous Sinus Thrombosis in COVID-19 Infection: A Case Series and Review of The Literature. causal interaction,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239605&form=6&db=m Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33256833&form=6&db=m Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells. causal interaction,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277466&form=6&db=m CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292872&form=6&db=m The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia. causal interaction,ongoing research,unassigned 4,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33301988&form=6&db=m Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33335073&form=6&db=m Cross-species recognition of SARS-CoV-2 to bat ACE2. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33368089&form=6&db=m Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33401657&form=6&db=m The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417604&form=6&db=m Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2). causal interaction,therapeutic application,unassigned 1,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33426683&form=6&db=m Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33446655&form=6&db=m SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice. diagnostic usage,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33463909&form=6&db=m 17?-estradiol reduces SARS-CoV-2 infection in vitro. causal interaction,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489841&form=6&db=m Endocrine Involvement in COVID-19: Mechanisms, Clinical Features, and Implications for Care. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33493919&form=6&db=m Identification of potential SARS-CoV-2 entry inhibitors by targeting the interface region between the spike RBD and human ACE2. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33512650&form=6&db=m Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33521067&form=6&db=m Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33532776&form=6&db=m Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33532801&form=6&db=m Immune response to SARS-CoV-2 in the nasal mucosa in children and adults. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33629859&form=6&db=m Aptamer Conjugated Gold Nanostar-Based Distance-Dependent Nanoparticle Surface Energy Transfer Spectroscopy for Ultrasensitive Detection and Inactivation of Corona Virus. ongoing research,therapeutic application,unassigned 1,2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33645443&form=6&db=m A potential peptide inhibitor of SARS-CoV-2?S and human ACE2 complex. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649798&form=6&db=m COVID?19 and SARS?CoV?2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease. causal interaction,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33684258&form=6&db=m Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection. ongoing research,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791232&form=6&db=m Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33819740&form=6&db=m The contrasting role of nasopharyngeal angiotensin converting enzyme 2 (ACE2) transcription in SARS-CoV-2 infection: A cross-sectional study of people tested for COVID-19 in British Columbia, Canada. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33835386&form=6&db=m Scientific Hypothesis for Treatment of COVID-19's Lung Lesions by Adjusting ACE/ACE2 Imbalance. causal interaction,therapeutic application,unassigned 4,2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33847382&form=6&db=m Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro. causal interaction,therapeutic application,unassigned 4,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33850607&form=6&db=m Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33853637&form=6&db=m Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells. causal interaction,ongoing research,unassigned 2,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33897423&form=6&db=m 1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33921689&form=6&db=m Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33953295&form=6&db=m Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model. ongoing research,therapeutic application,unassigned 1,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33968142&form=6&db=m Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995847&form=6&db=m Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33996911&form=6&db=m Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2. causal interaction,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34066226&form=6&db=m Pathophysiological Association of Endothelial Dysfunction with Fatal Outcome in COVID-19. causal interaction,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34072087&form=6&db=m Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries. ongoing research,unassigned 2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102269&form=6&db=m Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agents. ongoing research,therapeutic application,unassigned 3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34109284&form=6&db=m Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics. ongoing research,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34151392&form=6&db=m The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34160563&form=6&db=m ACE2 Expression Is Upregulated in Inflammatory Corneal Epithelial Cells and Attenuated by Resveratrol. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34224022&form=6&db=m Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants. causal interaction,unassigned 2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34230707&form=6&db=m Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection. ongoing research,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34268510&form=6&db=m Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions. causal interaction,unassigned 1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34297311&form=6&db=m TNF-? Blockers Showed Prophylactic Effects in Preventing COVID-19 in Patients with Rheumatoid Arthritis and Seronegative Spondyloarthropathies: A Case-Control Study. causal interaction,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34316436&form=6&db=m TNF-? Blockers Showed Prophylactic Effects in Preventing COVID-19 in Patients with Rheumatoid Arthritis and Seronegative Spondyloarthropathies: A Case-Control Study. causal interaction,unassigned 3,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34345117&form=6&db=m Korean traditional foods as antiviral and respiratory disease prevention and treatments: A detailed review. causal interaction,therapeutic application,unassigned 3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34348076&form=6&db=m Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34359983&form=6&db=m SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain Signaling. causal interaction,ongoing research,unassigned 1,2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34360866&form=6&db=m Acute Kidney Injury in COVID-19. causal interaction,unassigned 4,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34425415&form=6&db=m Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection. causal interaction,ongoing research,unassigned 1,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34431266&form=6&db=m Effect of Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on COVID-19 outcome: A Record Based Observational Study in West Bengal. ongoing research,therapeutic application,unassigned 2,1,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445373&form=6&db=m SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection. unassigned - 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34521239&form=6&db=m Histopathological features of SARS-CoV-2 infection and relationships with organoid technology. causal interaction,unassigned 2,0 3.4.17.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34542979&form=6&db=m Chest CT Features from 58 Patients with COVID-19 Pneumonia from the Perspective of ACE2. causal interaction,unassigned 3,0 3.4.17.23 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33909265&form=6&db=m Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives. causal interaction,unassigned 4,0