3.1.11.3 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31422589&form=6&db=m [Clinical application of TCGA molecular classification in endometrial endometrioid carcinoma]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.11.3 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26423071&form=6&db=m Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384. unassigned - 3.1.11.3 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23447401&form=6&db=m Germline and somatic polymerase ? and ? mutations define a new class of hypermutated colorectal and endometrial cancers. causal interaction,unassigned 3,0 3.1.11.3 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24583393&form=6&db=m Replicative DNA polymerase mutations in cancer. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.11.3 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24788313&form=6&db=m A mutation in POLE predisposing to a multi-tumour phenotype. causal interaction,unassigned 4,0 3.1.11.3 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25370038&form=6&db=m Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. diagnostic usage,unassigned 1,0 3.1.11.3 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251183&form=6&db=m POLE mutations in families predisposed to cutaneous melanoma. causal interaction,unassigned 3,0 3.1.11.3 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30827058&form=6&db=m Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps. diagnostic usage,unassigned 1,0 3.1.11.3 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32792570&form=6&db=m Role of POLE and POLD1 in familial cancer. causal interaction,unassigned 2,0 3.1.11.3 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30422000&form=6&db=m TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis. ongoing research,unassigned 3,0 3.1.11.3 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1224809&form=6&db=m Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.1.11.3 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1224809&form=6&db=m Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.1.11.3 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20496420&form=6&db=m Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.1.11.3 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6320855&form=6&db=m The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured mammalian cells. unassigned - 3.1.11.3 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24552169&form=6&db=m IL-24 Gene Polymorphisms Are Associated with Cardiometabolic Parameters and Cardiovascular Risk Factors But Not with Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease Mexican Study. causal interaction,ongoing research,unassigned 2,1,0 3.1.11.3 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045533&form=6&db=m Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. causal interaction,unassigned 3,0 3.1.11.3 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22071149&form=6&db=m Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. causal interaction,unassigned 4,0 3.1.11.3 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25848017&form=6&db=m Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. unassigned - 3.1.11.3 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28334850&form=6&db=m Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion. causal interaction,unassigned 1,0 3.1.11.3 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955997&form=6&db=m An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis. causal interaction,unassigned 2,0 3.1.11.3 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33868310&form=6&db=m TREX1 as a Novel Immunotherapeutic Target. causal interaction,unassigned 3,0 3.1.11.3 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33892200&form=6&db=m Systemic lupus erythematosus overlapping dermatomyositis owing to a heterozygous TREX1 Asp130Asn missense mutation. causal interaction,therapeutic application,unassigned 2,1,0 3.1.11.3 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32548621&form=6&db=m The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan. unassigned - 3.1.11.3 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209495&form=6&db=m Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity. causal interaction,ongoing research,unassigned 1,4,0 3.1.11.3 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21567745&form=6&db=m Problem-solving test: Real-time polymerase chain reaction. unassigned - 3.1.11.3 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21602889&form=6&db=m The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites. diagnostic usage,unassigned 1,0 3.1.11.3 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22617257&form=6&db=m An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification. therapeutic application,unassigned 1,0 3.1.11.3 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18312465&form=6&db=m Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.11.3 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29604063&form=6&db=m Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response. causal interaction,unassigned 3,0 3.1.11.3 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31331910&form=6&db=m DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing. causal interaction,unassigned 1,0 3.1.11.3 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31616062&form=6&db=m Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis. ongoing research,unassigned 3,0 3.1.11.3 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513814&form=6&db=m Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells. therapeutic application,unassigned 1,0 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19223232&form=6&db=m Quantitative multiplex PCR assay for the detection of the seven clinically most relevant high-risk HPV types. diagnostic usage,unassigned 3,0 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23447401&form=6&db=m Germline and somatic polymerase ? and ? mutations define a new class of hypermutated colorectal and endometrial cancers. causal interaction,unassigned 3,0 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24583393&form=6&db=m Replicative DNA polymerase mutations in cancer. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975040&form=6&db=m Mixed and Ambiguous Endometrial Carcinomas: A Heterogenous Group of Tumors With Different Clinicopathologic and Molecular Genetic Features. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27491810&form=6&db=m Molecular genetic heterogeneity in undifferentiated endometrial carcinomas. diagnostic usage,unassigned 3,0 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498284&form=6&db=m Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28863077&form=6&db=m Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins. causal interaction,unassigned 1,0 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29246451&form=6&db=m Molecular insights into the classification of high-grade endometrial carcinoma. unassigned - 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30827058&form=6&db=m Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps. diagnostic usage,unassigned 1,0 3.1.11.3 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31829441&form=6&db=m p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies. unassigned - 3.1.11.3 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15715&form=6&db=m The subcellular distribution of poly-A-degrading activity in mouse kidney. unassigned - 3.1.11.3 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844595&form=6&db=m POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 3.1.11.3 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25394778&form=6&db=m Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.1.11.3 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26166557&form=6&db=m Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.11.3 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29246451&form=6&db=m Molecular insights into the classification of high-grade endometrial carcinoma. unassigned - 3.1.11.3 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33870849&form=6&db=m Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases. ongoing research,unassigned 2,0 3.1.11.3 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28711739&form=6&db=m Homozygous c.359del variant in MGME1 is associated with early onset cerebellar ataxia. therapeutic application,unassigned 1,0 3.1.11.3 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22138376&form=6&db=m Repair of persistent strand breaks in the mitochondrial genome. causal interaction,unassigned 3,0 3.1.11.3 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482632&form=6&db=m Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD. diagnostic usage,unassigned 3,0 3.1.11.3 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32079623&form=6&db=m Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21157497&form=6&db=m Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23528559&form=6&db=m DNA polymerase {epsilon} and ? exonuclease domain mutations in endometrial cancer. causal interaction,unassigned 3,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24509466&form=6&db=m Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition. causal interaction,unassigned 2,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24788313&form=6&db=m A mutation in POLE predisposing to a multi-tumour phenotype. causal interaction,unassigned 4,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124163&form=6&db=m Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment. unassigned - 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25370038&form=6&db=m Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. diagnostic usage,unassigned 1,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26133394&form=6&db=m POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance. causal interaction,unassigned 3,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251183&form=6&db=m POLE mutations in families predisposed to cutaneous melanoma. causal interaction,unassigned 3,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423643&form=6&db=m POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer. diagnostic usage,unassigned 3,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28531315&form=6&db=m The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes. unassigned - 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29072370&form=6&db=m POLE somatic mutations in advanced colorectal cancer. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29120461&form=6&db=m Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1. diagnostic usage,unassigned 1,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31053176&form=6&db=m DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31857678&form=6&db=m High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32012149&form=6&db=m Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer. ongoing research,therapeutic application,unassigned 1,1,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32424176&form=6&db=m Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction. ongoing research,unassigned 2,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32548621&form=6&db=m The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan. unassigned - 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32567205&form=6&db=m POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East. unassigned - 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32792570&form=6&db=m Role of POLE and POLD1 in familial cancer. causal interaction,unassigned 2,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859741&form=6&db=m Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33764464&form=6&db=m Mutagenic mechanisms of cancer-associated DNA polymerase ? alleles. unassigned - 3.1.11.3 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34148618&form=6&db=m Unraveling the genomic landscape of colorectal cancer through mutational signatures. therapeutic application,unassigned 1,0 3.1.11.3 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32205482&form=6&db=m Endometrial Carcinomas with a "Serous" Component in Young Women Are Enriched for DNA Mismatch Repair Deficiency, Lynch Syndrome, and POLE Exonuclease Domain Mutations. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.11.3 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15128052&form=6&db=m Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. diagnostic usage,unassigned 3,0 3.1.11.3 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33024223&form=6&db=m Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir. therapeutic application,unassigned 2,0 3.1.11.3 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34312622&form=6&db=m Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 3.1.11.3 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34354677&form=6&db=m Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening. causal interaction,therapeutic application,unassigned 3,4,0 3.1.11.3 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750734&form=6&db=m Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis. causal interaction,unassigned 3,0 3.1.11.3 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944473&form=6&db=m POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features. causal interaction,unassigned 1,0 3.1.11.3 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11377710&form=6&db=m Development of a fluorogenic RT-PCR system for quantitative identification of dengue virus serotypes 1-4 using conserved and serotype-specific 3' noncoding sequences. diagnostic usage,unassigned 1,0 3.1.11.3 Diffuse Cerebral Sclerosis of Schilder http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22125488&form=6&db=m Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study. unassigned - 3.1.11.3 Disorders of Sex Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24854532&form=6&db=m Clinical applicability of rapid detection of SRY and DYS14 genes in patients with disorders of sex development using an indigenously developed 5' exonuclease based assay. diagnostic usage,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2996753&form=6&db=m Flow cytometric DNA and 5'-nucleotide phosphodiesterase in endometrium. causal interaction,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23528559&form=6&db=m DNA polymerase {epsilon} and ? exonuclease domain mutations in endometrial cancer. causal interaction,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770608&form=6&db=m An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. causal interaction,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24509466&form=6&db=m Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition. causal interaction,unassigned 2,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844595&form=6&db=m POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24861832&form=6&db=m DNA polymerase ? and its roles in genome stability. causal interaction,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25224212&form=6&db=m Polymerase ? (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing. diagnostic usage,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25394778&form=6&db=m Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25878334&form=6&db=m POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer. causal interaction,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763250&form=6&db=m Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26937754&form=6&db=m Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27491810&form=6&db=m Molecular genetic heterogeneity in undifferentiated endometrial carcinomas. diagnostic usage,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28079598&form=6&db=m Interobserver Agreement in Endometrial Carcinoma Histotype Diagnosis Varies Depending on The Cancer Genome Atlas (TCGA)-based Molecular Subgroup. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498284&form=6&db=m Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28776572&form=6&db=m Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28795426&form=6&db=m Blinded histopathological characterisation of POLE exonuclease domain-mutant endometrial cancers: sheep in wolf's clothing. unassigned - 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31335355&form=6&db=m p53, Mismatch Repair Protein, and POLE Abnormalities in Ovarian Clear Cell Carcinoma: An Outcome-based Clinicopathologic Analysis. diagnostic usage,unassigned 1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31757464&form=6&db=m Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31829442&form=6&db=m Interpretation of somatic POLE mutations in endometrial carcinoma. causal interaction,ongoing research,unassigned 3,3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31864301&form=6&db=m POLE mutations improve the prognosis of endometrial cancer via regulating cellular metabolism through AMF/AMFR signal transduction. causal interaction,therapeutic application,unassigned 4,4,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31980219&form=6&db=m Analysis of 108 patients with endometrial carcinoma using the PROMISE classification and additional genetic analyses for MMR-D. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32080141&form=6&db=m Clinicopathological characteristics and prognostic value of POLE mutations in endometrial cancer: A systematic review and meta-analysis. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32205482&form=6&db=m Endometrial Carcinomas with a "Serous" Component in Young Women Are Enriched for DNA Mismatch Repair Deficiency, Lynch Syndrome, and POLE Exonuclease Domain Mutations. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32384322&form=6&db=m Molecular Heterogeneity of Endometrioid Ovarian Carcinoma: An Analysis of 166 Cases Using the Endometrial Cancer Subrogate Molecular Classification. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32548621&form=6&db=m The first case report of polymerase proofreading-associated polyposis in POLD1 variant, c.1433G>A p.S478N, in Japan. unassigned - 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801757&form=6&db=m POLE Mutation Characteristics in a Chinese Cohort with Endometrial Carcinoma. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33001133&form=6&db=m First description of ultramutated endometrial cancer caused by germline loss-of-function and somatic exonuclease domain mutations in POLE gene. unassigned - 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33189427&form=6&db=m Molecular characterization in the prediction of disease extent in endometrial carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589443&form=6&db=m p53abn Endometrial Cancer: understanding the most aggressive endometrial cancers in the era of molecular classification. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806979&form=6&db=m The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions. diagnostic usage,unassigned 3,0 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34272092&form=6&db=m PD-L1 expression in tumor cells is associated with a favorable prognosis in patients with high-risk endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.1.11.3 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34493823&form=6&db=m Analysis of the immune checkpoint V-domain Ig-containing suppressor of T-cell activation (VISTA) in endometrial cancer. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7498761&form=6&db=m DNA structures generated during recombination initiated by mismatch repair of UV-irradiated nonreplicating phage DNA in Escherichia coli: requirements for helicase, exonucleases, and RecF and RecBCD functions. ongoing research,unassigned 2,0 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7680757&form=6&db=m The effect of the 3'-->5' exonuclease of T7 DNA polymerase on frameshifts and deletions. unassigned - 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657948&form=6&db=m Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10049912&form=6&db=m Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coli. causal interaction,therapeutic application,unassigned 1,2,0 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18406216&form=6&db=m TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders. unassigned - 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420083&form=6&db=m A Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, And Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1. unassigned - 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459099&form=6&db=m Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli. causal interaction,unassigned 4,0 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32756902&form=6&db=m Mismatch repair and DNA polymerase ? proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ? variant. ongoing research,unassigned 2,0 3.1.11.3 exodeoxyribonuclease (lambda-induced) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33135056&form=6&db=m Construction of a highly error-prone DNA polymerase for developing organelle mutation systems. unassigned - 3.1.11.3 exodeoxyribonuclease vii deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=368015&form=6&db=m Pyrimidine dimer excision in Escherichia coli strains deficient in exonucleases V and VII and in the 5' leads to 3' exonuclease of DNA polymerase I. unassigned - 3.1.11.3 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320300&form=6&db=m G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex. therapeutic application,unassigned 1,0 3.1.11.3 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26980189&form=6&db=m Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction. causal interaction,unassigned 3,0 3.1.11.3 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9707590&form=6&db=m The role of SOS and flap processing in microsatellite instability in Escherichia coli. unassigned - 3.1.11.3 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16263719&form=6&db=m Functional human mitochondrial DNA polymerase gamma forms a heterotrimer. causal interaction,therapeutic application,unassigned 4,3,0 3.1.11.3 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18406216&form=6&db=m TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders. unassigned - 3.1.11.3 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23578789&form=6&db=m Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.1.11.3 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34313201&form=6&db=m No association of microRNA-146a rs2910164 polymorphism and risk of primary gout development in Chinese Han populations: a case-control study. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.11.3 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29963243&form=6&db=m Interferon-stimulated gene 20 kDa protein serum levels and clinical outcome of hepatitis B virus-related liver diseases. therapeutic application,unassigned 1,0 3.1.11.3 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23794439&form=6&db=m Differential expression of ISG20 in chronic hepatitis B patients and relation to interferon-alpha therapy response. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 3.1.11.3 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232183&form=6&db=m T5 exonuclease hydrolysis of Hepatitis B Virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR. therapeutic application,unassigned 2,0 3.1.11.3 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32059034&form=6&db=m Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts. therapeutic application,unassigned 3,0 3.1.11.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23248316&form=6&db=m Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication. unassigned - 3.1.11.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23663760&form=6&db=m [Antiviral activities of ISG20 against hepatitis C virus]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 3.1.11.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24782267&form=6&db=m Interferon stimulated exonuclease gene 20?kDa links psychiatric events to distinct hepatitis C virus responses in human immunodeficiency virus positive patients. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.11.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25662750&form=6&db=m miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation. unassigned - 3.1.11.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30038017&form=6&db=m RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus. unassigned - 3.1.11.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31891998&form=6&db=m A highly sensitive and selective fluorescence biosensor for hepatitis C virus DNA detection based on ?-FeOOH and exonuclease III-assisted signal amplification. diagnostic usage,unassigned 3,0 3.1.11.3 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34312622&form=6&db=m Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 3.1.11.3 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23663760&form=6&db=m [Antiviral activities of ISG20 against hepatitis C virus]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=176427&form=6&db=m Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=223846&form=6&db=m Properties of herpes simplex virus DNA polymerase and characterization of its associated exonuclease activity. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=226938&form=6&db=m Electron microscopic mapping of proteins bound to herpes simplex virus DNA. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314195&form=6&db=m Improved band shift assay for the simultaneous analysis of protein-DNA interactions and enzymatic functions of DNA polymerases. diagnostic usage,unassigned 3,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005609&form=6&db=m Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3010237&form=6&db=m DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes. ongoing research,unassigned 3,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018551&form=6&db=m Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation. ongoing research,therapeutic application,unassigned 1,2,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3020158&form=6&db=m Intranuclear localization of herpes simplex virus immediate-early and delayed-early proteins: evidence that ICP 4 is associated with progeny virus DNA. therapeutic application,unassigned 1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031067&form=6&db=m Processive replication of single-stranded DNA templates by the herpes simplex virus-induced DNA polymerase. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6092371&form=6&db=m Novel interaction of aphidicolin with herpes simplex virus DNA polymerase and polymerase-associated exonuclease. therapeutic application,unassigned 2,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6167579&form=6&db=m Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation. ongoing research,unassigned 2,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6287023&form=6&db=m mRNA- and DNA-directed synthesis of herpes simplex virus-coded exonuclease in Xenopus laevis oocytes. ongoing research,unassigned 1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6313961&form=6&db=m High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6328043&form=6&db=m Physical mapping of the herpes simplex virus type 2 nuc- lesion affecting alkaline exonuclease activity by using herpes simplex virus type 1 deletion clones. ongoing research,therapeutic application,unassigned 3,1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6330522&form=6&db=m Structural and functional properties of DNA polymerase delta from rabbit bone marrow. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627727&form=6&db=m Purification and characterization of herpes simplex virus type 1 alkaline exonuclease expressed in Escherichia coli. ongoing research,therapeutic application,unassigned 4,1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8910584&form=6&db=m Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9311864&form=6&db=m Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9527934&form=6&db=m Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364279&form=6&db=m Effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus DNA polymerase on the fidelity of DNA replication in vivo. ongoing research,unassigned 2,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11290737&form=6&db=m The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions. diagnostic usage,unassigned 1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992012&form=6&db=m Mutation spectra of herpes simplex virus type 1 thymidine kinase mutants. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584319&form=6&db=m Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941927&form=6&db=m 3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15135733&form=6&db=m On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420083&form=6&db=m A Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, And Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20943970&form=6&db=m Physical Interaction between the Herpes Simplex Virus Type 1 Exonuclease, UL12, and the DNA double strand break sensing MRN complex. ongoing research,unassigned 1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335305&form=6&db=m Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence. causal interaction,unassigned 1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25517265&form=6&db=m Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26836009&form=6&db=m Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28956767&form=6&db=m The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30696089&form=6&db=m The Role of Marek's Disease Virus UL12 and UL29 in DNA Recombination and the Virus Lifecycle. unassigned - 3.1.11.3 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100840075&form=6&db=m High-Resolution Characterization of Herpes Simplex Virus Type 1 Transcripts Encoding Alkaline Exonuclease and a 50,000-Dalton Protein Tentatively Identified as a Capsid Protein. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805844&form=6&db=m Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.11.3 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6311255&form=6&db=m Structure of chromatin at deoxyribonucleic acid replication forks: nuclease hypersensitivity results from both prenucleosomal deoxyribonucleic acid and an immature chromatin structure. diagnostic usage,unassigned 3,0 3.1.11.3 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509295&form=6&db=m Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. unassigned - 3.1.11.3 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085492&form=6&db=m Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. unassigned - 3.1.11.3 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18923075&form=6&db=m DNA helicases Sgs1 and BLM promote DNA double-strand break resection. unassigned - 3.1.11.3 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25108836&form=6&db=m Functional variants of human APE1 rescue the DNA repair defects of the yeast AP endonuclease/3'-diesterase-deficient strain. causal interaction,unassigned 3,0 3.1.11.3 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805844&form=6&db=m Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170664&form=6&db=m Role of gene 6 exonuclease in the replication and packaging of bacteriophage T7 DNA. causal interaction,unassigned 1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3020158&form=6&db=m Intranuclear localization of herpes simplex virus immediate-early and delayed-early proteins: evidence that ICP 4 is associated with progeny virus DNA. therapeutic application,unassigned 1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4886307&form=6&db=m Separation and characterization of deoxyribonucleases of Escherichia coli B. II. Further purification and properties of an exonuclease induced by infection with bacteriophage T2. ongoing research,therapeutic application,unassigned 1,2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4945393&form=6&db=m [Study of the lambda-exonuclease activity of Escherichia coli during induction of the vegetative phage and infection with temperate phage lambda] ongoing research,therapeutic application,unassigned 3,1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6226560&form=6&db=m Expression of the phage lambda recombination genes exo and bet under lacPO control on a multi-copy plasmid. unassigned - 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6271263&form=6&db=m [Biosynthesis of early enzymes induced by bacteriophage T4] unassigned - 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6375120&form=6&db=m Formation of phage T1 concatemers by the RecE recombination pathway of Escherichia coli. ongoing research,unassigned 2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090176&form=6&db=m Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,2 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16562064&form=6&db=m Repression of lambda-Associated Enzyme Synthesis After lambda(vir) Superinfection of Lysogenic Hosts. causal interaction,therapeutic application,unassigned 1,2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19266025&form=6&db=m The SET complex acts as a barrier to autointegration of HIV-1. therapeutic application,unassigned 2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19700564&form=6&db=m Extracellular DNA is required for root tip resistance to fungal infection. causal interaction,therapeutic application,unassigned 2,1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262835&form=6&db=m Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. causal interaction,unassigned 1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022268&form=6&db=m A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression. unassigned - 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22696660&form=6&db=m The "Bridge" in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection. causal interaction,ongoing research,unassigned 1,1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22763968&form=6&db=m Comparison of the sensitivity and specificity of real-time PCR and in situ hybridization in HPV16 and 18 detection in archival cervical cancer specimens. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24673931&form=6&db=m Identification of in vivo regulators of the Vibrio cholerae?xds gene using a high-throughput genetic selection. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24744377&form=6&db=m The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production. unassigned - 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25070851&form=6&db=m The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502648&form=6&db=m Silencing the shutoff protein of Epstein-Barr virus in productively infected B cells points to (innate) targets for immune evasion. causal interaction,unassigned 2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25646359&form=6&db=m SAMHD1's protein expression profile in humans. ongoing research,unassigned 1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26676792&form=6&db=m Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27934765&form=6&db=m Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30352932&form=6&db=m HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection. therapeutic application,unassigned 2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30728255&form=6&db=m The DNase Activity of KSHV SOX Protein Serves an Important Role in Viral Genome Processing During Lytic Replication. causal interaction,therapeutic application,unassigned 4,2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32977742&form=6&db=m Comparative transcriptomic analysis of Rickettsia conorii during in vitro infection of human and tick host cells. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33080971&form=6&db=m Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. unassigned - 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33603016&form=6&db=m The PHP domain of PolX from Staphylococcus aureus aids high fidelity DNA synthesis through the removal of misincorporated deoxyribo-, ribo- and oxidized nucleotides. therapeutic application,unassigned 2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33870849&form=6&db=m Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases. ongoing research,unassigned 2,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34105995&form=6&db=m Human Three Prime Repair Exonuclease 1 Promotes HIV-1 Integration by Preferentially Degrading Unprocessed Viral DNA. causal interaction,unassigned 4,0 3.1.11.3 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34284057&form=6&db=m Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors. ongoing research,unassigned 1,0 3.1.11.3 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31450475&form=6&db=m Ultrasensitive SERS determination of avian influenza A H7N9 virus via exonuclease III-assisted cycling amplification. unassigned - 3.1.11.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30253126&form=6&db=m Fluorometric detection of influenza viral RNA using graphene oxide. causal interaction,unassigned 1,0 3.1.11.3 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32960265&form=6&db=m Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription. causal interaction,therapeutic application,unassigned 1,1,0 3.1.11.3 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31053176&form=6&db=m DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Lassa Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27529560&form=6&db=m Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES). therapeutic application,unassigned 1,0 3.1.11.3 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833512&form=6&db=m A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.11.3 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527892&form=6&db=m p53-associated 3'-->5' exonuclease activity in nuclear and cytoplasmic compartments of cells. causal interaction,unassigned 1,0 3.1.11.3 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521941&form=6&db=m Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.11.3 Leukoencephalopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805844&form=6&db=m Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.11.3 Lipodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750734&form=6&db=m Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis. causal interaction,unassigned 3,0 3.1.11.3 Liver Neoplasms, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6253467&form=6&db=m Interaction of mammalian deoxyribonuclease V, a double strand 3' to 5' and 5' to 3' exonuclease, with deoxyribonucleic acid polymerase-beta from the Novikoff hepatoma. ongoing research,unassigned 1,0 3.1.11.3 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17660818&form=6&db=m Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. unassigned - 3.1.11.3 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25261479&form=6&db=m Intrinsic self-DNA triggers inflammatory disease dependent on STING. causal interaction,therapeutic application,unassigned 3,2,0 3.1.11.3 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29781188&form=6&db=m Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice. causal interaction,unassigned 4,0 3.1.11.3 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955997&form=6&db=m An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis. causal interaction,unassigned 2,0 3.1.11.3 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31326279&form=6&db=m TREX1 variants in Sjogren's syndrome related lymphomagenesis. unassigned - 3.1.11.3 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10982859&form=6&db=m SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories. unassigned - 3.1.11.3 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9665466&form=6&db=m Novel 5' exonuclease-based real-time PCR assay for the detection of t(14;18)(q32;q21) in patients with follicular lymphoma. diagnostic usage,unassigned 3,0 3.1.11.3 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19382019&form=6&db=m Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes. unassigned - 3.1.11.3 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12937979&form=6&db=m Increased sensitivity of B-cell clonality analysis in formalin-fixed and paraffin-embedded B-cell lymphoma samples using an enzyme blend with both 5'-->3' DNA polymerase and 3'-->5' exonuclease activity. causal interaction,unassigned 1,0 3.1.11.3 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32711538&form=6&db=m Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 3.1.11.3 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23578789&form=6&db=m Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.1.11.3 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251183&form=6&db=m POLE mutations in families predisposed to cutaneous melanoma. causal interaction,unassigned 3,0 3.1.11.3 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34519260&form=6&db=m Carboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma. therapeutic application,unassigned 1,0 3.1.11.3 Meningococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12409421&form=6&db=m 5' exonuclease assay for detection of serogroup Y Neisseria meningitidis. diagnostic usage,unassigned 1,0 3.1.11.3 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32782682&form=6&db=m ISG20 is overexpressed in clinically relevant radioresistant oral cancer cells. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.11.3 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30724665&form=6&db=m Exonuclease domain mutants of yeast DIS3 display genome instability. causal interaction,unassigned 1,0 3.1.11.3 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21497709&form=6&db=m Extracellular DNA: the tip of root defenses? causal interaction,unassigned 3,0 3.1.11.3 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100051114&form=6&db=m Extracellular DNA: The tip of root defenses causal interaction,unassigned 3,0 3.1.11.3 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22785600&form=6&db=m The Matrix Metalloproteinase 2-1575 gene Polymorphism is Associated with the Risk of Developing Myocardial Infarction in Mexican Patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.11.3 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254239&form=6&db=m Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. ongoing research,therapeutic application,unassigned 1,1,0 3.1.11.3 Myotonic Dystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16978612&form=6&db=m Fen1 does not control somatic hypermutability of the (CTG)(n).(CAG)(n) repeat in a knock-in mouse model for DM1. ongoing research,unassigned 3,0 3.1.11.3 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209495&form=6&db=m Metastasis suppressor function of NM23-H1 requires its 3';-5' exonuclease activity. causal interaction,ongoing research,unassigned 1,4,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15715&form=6&db=m The subcellular distribution of poly-A-degrading activity in mouse kidney. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026639&form=6&db=m Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6078099&form=6&db=m Hydrolysis of deoxyribo-oligonucleotides bearing 3'-monoesterified phosphate by mouse mammary tumor exonuclease. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8758918&form=6&db=m Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9218592&form=6&db=m Normal junctional diversification of immune receptors in p53-deficient mice. causal interaction,therapeutic application,unassigned 1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9468331&form=6&db=m Exonuclease enhances hybridization efficiency: improved direct cycle sequencing and point mutation detection. diagnostic usage,therapeutic application,unassigned 4,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10414414&form=6&db=m Additional value of K-ras point mutations in bronchial wash fluids for diagnosis of peripheral lung tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11427532&form=6&db=m p53 Modulates the exonuclease activity of Werner syndrome protein. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11454523&form=6&db=m Quantification of human cells in NOD/SCID mice by duplex real-time polymerase-chain reaction. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11753641&form=6&db=m p53 enhances the fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase. causal interaction,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429860&form=6&db=m High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527892&form=6&db=m p53-associated 3'-->5' exonuclease activity in nuclear and cytoplasmic compartments of cells. causal interaction,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12806015&form=6&db=m The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15286711&form=6&db=m P53 in cytoplasm may enhance the accuracy of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015833&form=6&db=m A role for WRN in telomere-based DNA damage responses. ongoing research,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18312465&form=6&db=m Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287302&form=6&db=m Excision of nucleoside analogs in mitochondria by p53 protein. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19347053&form=6&db=m Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. diagnostic usage,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519945&form=6&db=m p53 in cytoplasm exerts 3'-->5' exonuclease activity with dsRNA. diagnostic usage,therapeutic application,unassigned 1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21383776&form=6&db=m Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23555580&form=6&db=m Multiple hits for the association of uterine fibroids on human chromosome 1q43. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23578789&form=6&db=m Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24048476&form=6&db=m Genomic organization of human transcription initiation complexes. ongoing research,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24525744&form=6&db=m A Common Cancer-Associated DNA Polymerase {varepsilon} Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading. causal interaction,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24861832&form=6&db=m DNA polymerase ? and its roles in genome stability. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25228659&form=6&db=m Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25394778&form=6&db=m Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25414327&form=6&db=m Significant contribution of the 3'?5' exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ?. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648449&form=6&db=m Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26763250&form=6&db=m Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27108253&form=6&db=m Fluorescence detection of telomerase activity in cancer cell extracts based on autonomous exonuclease III-assisted isothermal cycling signal amplification. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27421752&form=6&db=m Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment. diagnostic usage,therapeutic application,unassigned 1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27486176&form=6&db=m Regression of chemotherapy-resistant Polymerase epsilon (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27491810&form=6&db=m Molecular genetic heterogeneity in undifferentiated endometrial carcinomas. diagnostic usage,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27689337&form=6&db=m p53 in the mitochondria, as a trans-acting protein, provides error-correction activities during the incorporation of non-canonical dUTP into DNA. diagnostic usage,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28061006&form=6&db=m Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28081035&form=6&db=m Removal of ribonucleotides by p53 protein incorporated during DNA synthesis by HIV-1 reverse transcriptase. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28368425&form=6&db=m Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase ? mutation in human cells. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28465371&form=6&db=m DNA Polymerase ? Deficiency Leading to an Ultramutator Phenotype: A Novel Clinically Relevant Entity. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498284&form=6&db=m Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28598415&form=6&db=m DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28687338&form=6&db=m Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28776572&form=6&db=m Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28805995&form=6&db=m Germline PMS2 and somatic POLEexo mutations cause hypermutability of the leading DNA strand in Biallelic Mismatch Repair Deficiency syndrome brain tumors. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28846956&form=6&db=m Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine. diagnostic usage,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28863077&form=6&db=m Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins. causal interaction,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28932642&form=6&db=m TREX1 dictates the immune fate of irradiated cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28945609&form=6&db=m Does a p53 "Wild-type" Immunophenotype Exclude a Diagnosis of Endometrial Serous Carcinoma? unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29133142&form=6&db=m Dedifferentiated endometrial carcinomas with neuroendocrine features: a clinicopathologic, immunohistochemical, and molecular genetic study. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29320758&form=6&db=m Polymerase epsilon mutations and concomitant ?2-microglobulin mutations in cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352080&form=6&db=m Functional Analysis of Cancer-Associated DNA Polymerase ? Variants in ongoing research,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29396409&form=6&db=m Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29470985&form=6&db=m Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29500597&form=6&db=m Fidelity of DNA replication-a matter of proofreading. causal interaction,unassigned 4,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29604063&form=6&db=m Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29893116&form=6&db=m DNA-Conjugated Amphiphilic Aggregation-Induced Emission Probe for Cancer Tissue Imaging and Prognosis Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29954251&form=6&db=m Functional role of circular RNAs in cancer development and progression. diagnostic usage,therapeutic application,unassigned 4,4,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670691&form=6&db=m A recurrent cancer-associated substitution in DNA polymerase ? produces a hyperactive enzyme. unassigned - 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30713788&form=6&db=m ISG20 promotes local tumor immunity and contributes to poor survival in human glioma. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30776091&form=6&db=m A proposal for updating the staging of endometrial cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30908539&form=6&db=m The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30917185&form=6&db=m Phenotype of POLE-mutated endometrial cancer. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30971823&form=6&db=m WRN helicase is a synthetic lethal target in microsatellite unstable cancers. causal interaction,therapeutic application,unassigned 3,3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31053176&form=6&db=m DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31240875&form=6&db=m Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31567131&form=6&db=m Classification of Endometrial Carcinoma: New Perspectives Beyond Morphology. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,3 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31750734&form=6&db=m Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis. causal interaction,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828326&form=6&db=m APE1 senses DNA single-strand breaks for repair and signaling. ongoing research,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31829442&form=6&db=m Interpretation of somatic POLE mutations in endometrial carcinoma. causal interaction,ongoing research,unassigned 3,3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31829447&form=6&db=m Clinicopathological and molecular characterisation of 'multiple-classifier' endometrial carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31857678&form=6&db=m High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944473&form=6&db=m POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features. causal interaction,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32012149&form=6&db=m Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer. ongoing research,therapeutic application,unassigned 1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32079623&form=6&db=m Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32352724&form=6&db=m Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497495&form=6&db=m POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513814&form=6&db=m Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32749941&form=6&db=m Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32756902&form=6&db=m Mismatch repair and DNA polymerase ? proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ? variant. ongoing research,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758138&form=6&db=m Germline RAD54L with somatic POLE defect implicated in Hypermutation phenotype: case report. causal interaction,ongoing research,unassigned 3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32782682&form=6&db=m ISG20 is overexpressed in clinically relevant radioresistant oral cancer cells. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32792570&form=6&db=m Role of POLE and POLD1 in familial cancer. causal interaction,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32838755&form=6&db=m Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859741&form=6&db=m Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32938641&form=6&db=m Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade. ongoing research,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33085544&form=6&db=m Analysis of CNOT Family Gene Expression, Clinicopathological Features, and Prognosis Value in Hepatocellular Carcinoma. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33398111&form=6&db=m Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles. therapeutic application,unassigned 1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33449452&form=6&db=m Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer. diagnostic usage,unassigned 3,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33589443&form=6&db=m p53abn Endometrial Cancer: understanding the most aggressive endometrial cancers in the era of molecular classification. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33650643&form=6&db=m Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review). causal interaction,therapeutic application,unassigned 2,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33896836&form=6&db=m High expression of ISG20 predicts a poor prognosis in acute myeloid leukemia. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33975701&form=6&db=m An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115671&form=6&db=m Corded and Hyalinized and Spindled Endometrioid Endometrial Carcinoma: A Clinicopathologic and Molecular Analysis of 9 Tumors Based on the TCGA Classifier. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34206702&form=6&db=m Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Molecularly Classified Endometrial Carcinoma. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34228493&form=6&db=m FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair. causal interaction,unassigned 2,0 3.1.11.3 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34529911&form=6&db=m Pre-treatment risk assessment of women with endometrial cancer: differences in outcomes of molecular and clinical classifications in the Slovenian patient cohort. diagnostic usage,unassigned 1,0 3.1.11.3 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980716&form=6&db=m Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.11.3 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21700224&form=6&db=m Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. therapeutic application,unassigned 1,0 3.1.11.3 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23022480&form=6&db=m Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA. unassigned - 3.1.11.3 Ophthalmoplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16263719&form=6&db=m Functional human mitochondrial DNA polymerase gamma forms a heterotrimer. causal interaction,therapeutic application,unassigned 4,3,0 3.1.11.3 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575643&form=6&db=m Removal of anti-human immunodeficiency virus 2',3'-dideoxynucleoside monophosphates from DNA by a novel human cytosolic 3'-->5' exonuclease. ongoing research,unassigned 3,0 3.1.11.3 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127259&form=6&db=m Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. causal interaction,unassigned 1,0 3.1.11.3 Progeria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29572490&form=6&db=m Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria. causal interaction,ongoing research,unassigned 2,1,0 3.1.11.3 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12054518&form=6&db=m Pseudorabies virus DNA-binding protein stimulates the exonuclease activity and regulates the processivity of pseudorabies virus DNase. ongoing research,therapeutic application,unassigned 2,2,0 3.1.11.3 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19469905&form=6&db=m Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.3 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27365293&form=6&db=m The Exonuclease Trex2 Shapes Psoriatic Phenotype. ongoing research,therapeutic application,unassigned 3,1,0 3.1.11.3 Retinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16457815&form=6&db=m The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage. unassigned - 3.1.11.3 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1713861&form=6&db=m DNA damage by peplomycin and its repair in an in vitro system. unassigned - 3.1.11.3 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2372879&form=6&db=m Repair of X-ray-induced single-strand breaks by a cell-free system. ongoing research,unassigned 4,0 3.1.11.3 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461264&form=6&db=m An exonuclease possibly involved in the initiation of repair of bleomycin-damaged DNA in mouse ascites sarcoma cells. unassigned - 3.1.11.3 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19824023&form=6&db=m Werner syndrome gene variants in human sarcomas. ongoing research,unassigned 4,0 3.1.11.3 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33173991&form=6&db=m Using mRNA deep sequencing to analyze differentially expressed genes during Panax notoginseng saponin treatment of ischemic stroke. unassigned - 3.1.11.3 Sarcoma 180 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8485154&form=6&db=m A 5' exoribonuclease from cytoplasmic extracts of mouse sarcoma 180 ascites cells. ongoing research,unassigned 4,0 3.1.11.3 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4324864&form=6&db=m DNA ligase and exonuclease activities in virions of rous sarcoma virus. unassigned - 3.1.11.3 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2456463&form=6&db=m Schistosoma mansoni: localisation of antigenic regions on the 31 kilodalton diagnostic protein. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.11.3 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25197083&form=6&db=m One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. therapeutic application,unassigned 1,0 3.1.11.3 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27365293&form=6&db=m The Exonuclease Trex2 Shapes Psoriatic Phenotype. ongoing research,therapeutic application,unassigned 3,1,0 3.1.11.3 Spinocerebellar Degenerations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28711739&form=6&db=m Homozygous c.359del variant in MGME1 is associated with early onset cerebellar ataxia. therapeutic application,unassigned 1,0 3.1.11.3 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26720919&form=6&db=m Two-stage cyclic enzymatic amplification method for ultrasensitive electrochemical assay of microRNA-21 in the blood serum of gastric cancer patients. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.11.3 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805844&form=6&db=m Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.11.3 Superinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16562064&form=6&db=m Repression of lambda-Associated Enzyme Synthesis After lambda(vir) Superinfection of Lysogenic Hosts. causal interaction,therapeutic application,unassigned 1,2,0 3.1.11.3 Takayasu Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31816847&form=6&db=m Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.11.3 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2642505&form=6&db=m Studies of c-myb gene regulation in MRL-lpr/lpr mice. Identification of a 5' c-myb nuclear protein binding site and high levels of binding factors in nuclear extracts of lpr/lpr lymph node cells. unassigned - 3.1.11.3 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499016&form=6&db=m Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. unassigned - 3.1.11.3 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822057&form=6&db=m The ?2 clamp in the Mycobacterium tuberculosis DNA polymerase III ??2? replicase promotes polymerization and reduces exonuclease activity. ongoing research,unassigned 1,0 3.1.11.3 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641156&form=6&db=m Mechanistic insights into the enzymatic activity and inhibition of the replicative polymerase exonuclease domain from Mycobacterium tuberculosis. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.11.3 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31112916&form=6&db=m The construction of Mycobacterium tuberculosis 16S rDNA MSPQC sensor based on Exonuclease III-assisted cyclic signal amplification. unassigned - 3.1.11.3 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32232338&form=6&db=m M. tuberculosis class II apurinic/ apyrimidinic-endonuclease/3'-5' exonuclease (XthA) engages with NAD+-dependent DNA ligase A (LigA) to counter futile cleavage and ligation cycles in base excision repair. therapeutic application,unassigned 1,0 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=134999&form=6&db=m Action of ATP-dependent DNase from Hemophilus influenzae on cross-linked DNA molecules. unassigned - 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5015715&form=6&db=m Virus-associated nucleases: evidence for endonuclease and exonuclease activity in rabbitpox and vaccinia viruses. unassigned - 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6283106&form=6&db=m Shope fibroma virus. II. Role of the virion-associated nucleases. unassigned - 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16048917&form=6&db=m Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982794&form=6&db=m Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype. ongoing research,unassigned 4,0 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17158165&form=6&db=m Duplex strand joining reactions catalyzed by vaccinia virus DNA polymerase. ongoing research,unassigned 3,0 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056278&form=6&db=m Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand. causal interaction,therapeutic application,unassigned 2,4,0 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22688759&form=6&db=m In-fusion® cloning with vaccinia virus DNA polymerase. therapeutic application,unassigned 1,0 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766294&form=6&db=m Cellular 5'-3' mRNA Exonuclease Xrn1 Controls Double-Stranded RNA Accumulation and Anti-Viral Responses. therapeutic application,unassigned 1,0 3.1.11.3 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33586708&form=6&db=m Analysis of SEC-SAXS data via EFA deconvolution and Scatter. ongoing research,unassigned 2,0 3.1.11.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3021980&form=6&db=m A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo. ongoing research,unassigned 2,0 3.1.11.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22937163&form=6&db=m Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease. unassigned - 3.1.11.3 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30903969&form=6&db=m Early transcriptome profile of goat peripheral blood mononuclear cells (PBMCs) infected with peste des petits ruminant's vaccine virus (Sungri/96) revealed induction of antiviral response in an interferon independent manner. causal interaction,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852073&form=6&db=m Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852074&form=6&db=m Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10325426&form=6&db=m Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10880505&form=6&db=m Functional interaction between Ku and the werner syndrome protein in DNA end processing. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10954593&form=6&db=m Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316787&form=6&db=m Loss of Werner syndrome protein function promotes aberrant mitotic recombination. therapeutic application,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11427532&form=6&db=m p53 Modulates the exonuclease activity of Werner syndrome protein. therapeutic application,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477099&form=6&db=m Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11572872&form=6&db=m Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11717307&form=6&db=m DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA. causal interaction,unassigned 3,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12177300&form=6&db=m Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202749&form=6&db=m Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12427008&form=6&db=m The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro. causal interaction,unassigned 3,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12633936&form=6&db=m Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887585&form=6&db=m A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12937173&form=6&db=m Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein. ongoing research,therapeutic application,unassigned 3,1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712220&form=6&db=m TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA. therapeutic application,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084309&form=6&db=m The Werner syndrome protein has separable recombination and survival functions. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15187093&form=6&db=m Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15200954&form=6&db=m The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. causal interaction,unassigned 3,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15292449&form=6&db=m Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15336909&form=6&db=m The Werner syndrome protein at the crossroads of DNA repair and apoptosis. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15995249&form=6&db=m Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16141234&form=6&db=m Accumulation of Werner protein at DNA double-strand breaks in human cells. causal interaction,unassigned 3,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16503984&form=6&db=m Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains. therapeutic application,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622405&form=6&db=m WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015833&form=6&db=m A role for WRN in telomere-based DNA damage responses. ongoing research,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224176&form=6&db=m WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17717003&form=6&db=m Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity. causal interaction,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17943237&form=6&db=m Genetic instability syndromes with progeroid features. causal interaction,unassigned 3,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056975&form=6&db=m Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18596042&form=6&db=m The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19283071&form=6&db=m The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19824023&form=6&db=m Werner syndrome gene variants in human sarcomas. ongoing research,unassigned 4,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20157518&form=6&db=m Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. therapeutic application,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20516064&form=6&db=m Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20732421&form=6&db=m Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and Ataxia. therapeutic application,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763283&form=6&db=m DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127259&form=6&db=m Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. causal interaction,unassigned 1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22351772&form=6&db=m The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase ? causal interaction,unassigned 4,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23276657&form=6&db=m Disease-causing missense mutations in human DNA helicase disorders. causal interaction,therapeutic application,unassigned 3,1,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26347143&form=6&db=m Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review. unassigned - 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29494634&form=6&db=m Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein. causal interaction,unassigned 3,0 3.1.11.3 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30400178&form=6&db=m Werner Syndrome Protein and DNA Replication. causal interaction,unassigned 2,0 3.1.11.3 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23594738&form=6&db=m A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. unassigned - 3.1.11.3 Zika Virus Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405956&form=6&db=m Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection. ongoing research,unassigned 2,0