3.1.1.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204926&form=6&db=m Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. causal interaction,therapeutic application,unassigned 4,4,0 3.1.1.23 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25912803&form=6&db=m The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats. causal interaction,therapeutic application,unassigned 4,4,0 3.1.1.23 acylglycerol lipase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26075589&form=6&db=m Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic ?-opioid receptor sensitivity. causal interaction,ongoing research,unassigned 3,1,0 3.1.1.23 acylglycerol lipase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26584135&form=6&db=m Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.1.1.23 acylglycerol lipase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28380440&form=6&db=m Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.1.1.23 acylglycerol lipase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265576&form=6&db=m Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice. causal interaction,ongoing research,unassigned 2,2,0 3.1.1.23 acylglycerol lipase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527428&form=6&db=m Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.1.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348400&form=6&db=m Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.1.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363004&form=6&db=m Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.1.23 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23873026&form=6&db=m Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression. ongoing research,therapeutic application,unassigned 1,1,0 3.1.1.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459826&form=6&db=m Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. causal interaction,unassigned 1,0 3.1.1.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23122958&form=6&db=m Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0 3.1.1.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28733897&form=6&db=m Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors. ongoing research,therapeutic application,unassigned 2,1,0 3.1.1.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32483456&form=6&db=m Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,3,0 3.1.1.23 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31937359&form=6&db=m Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis. ongoing research,therapeutic application,unassigned 1,1,0 3.1.1.23 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26791214&form=6&db=m Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats. causal interaction,therapeutic application,unassigned 1,2,0 3.1.1.23 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34042520&form=6&db=m Monoacylglycerol Lipase Inhibition Using JZL184 Attenuates Paw Inflammation and Functional Deficits in a Mouse Model of Inflammatory Arthritis. causal interaction,therapeutic application,unassigned 2,1,0 3.1.1.23 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30609444&form=6&db=m Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner. causal interaction,unassigned 4,0 3.1.1.23 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22821058&form=6&db=m Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats. causal interaction,ongoing research,unassigned 2,1,0 3.1.1.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685433&form=6&db=m Identification of genes with altered expression in medullary breast cancer vs. ductal breast cancer and normal breast epithelia. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.1.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29906613&form=6&db=m Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-?B) signaling in cancer cells. causal interaction,ongoing research,unassigned 3,1,0 3.1.1.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31467232&form=6&db=m Comparative Proteome Analysis of Breast Cancer Tissues Highlights the Importance of Glycerol-3-phosphate Dehydrogenase 1 and Monoacylglycerol Lipase in Breast Cancer Metabolism. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.1.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20085702&form=6&db=m Chewing the fat on tumor cell metabolism. therapeutic application,unassigned 1,0 3.1.1.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357249&form=6&db=m Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer. causal interaction,ongoing research,unassigned 3,3,0 3.1.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27767105&form=6&db=m Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 3.1.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884159&form=6&db=m Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-?B-mediated epithelial-mesenchymal transition. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034939&form=6&db=m KLF4 suppresses the migration of hepatocellular carcinoma by transcriptionally upregulating monoglyceride lipase. causal interaction,therapeutic application,unassigned 1,1,0 3.1.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734989&form=6&db=m [Monoacylglycerol lipase high expression as an independent indicator of survival for patients with hepatocellular carcinoma]. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33768340&form=6&db=m Circulating prostaglandin E2: a novel potential prognostic biomarker in patients with hepatocellular carcinoma. diagnostic usage,therapeutic application,unassigned 4,1,0 3.1.1.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.1.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527428&form=6&db=m Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.1.23 Cerebral Cortical Thinning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31695165&form=6&db=m Brain structural changes in cannabis dependence: association with MAGL. unassigned - 3.1.1.23 Cholangitis, Sclerosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505038&form=6&db=m Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis. causal interaction,ongoing research,unassigned 2,1,0 3.1.1.23 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21551239&form=6&db=m Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. therapeutic application,unassigned 1,0 3.1.1.23 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25912803&form=6&db=m The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats. causal interaction,therapeutic application,unassigned 4,4,0 3.1.1.23 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28079617&form=6&db=m Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review. causal interaction,therapeutic application,unassigned 4,1,0 3.1.1.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23873026&form=6&db=m Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression. ongoing research,therapeutic application,unassigned 1,1,0 3.1.1.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968710&form=6&db=m Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543155&form=6&db=m Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349814&form=6&db=m Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26847687&form=6&db=m Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 3.1.1.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34431463&form=6&db=m Targeting triglyceride metabolism for colorectal cancer prevention and therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 3.1.1.23 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23953192&form=6&db=m Anticholinesterase insecticide action at the murine male reproductive system. causal interaction,therapeutic application,unassigned 2,2,0 3.1.1.23 Cystitis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31443753&form=6&db=m Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis. causal interaction,therapeutic application,unassigned 4,4,0 3.1.1.23 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25130621&form=6&db=m Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo. therapeutic application,unassigned 1,0 3.1.1.23 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25474204&form=6&db=m Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. ongoing research,therapeutic application,unassigned 3,2,0 3.1.1.23 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751457&form=6&db=m 2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination. ongoing research,therapeutic application,unassigned 1,4,0 3.1.1.23 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133454&form=6&db=m The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. unassigned - 3.1.1.23 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357249&form=6&db=m Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer. causal interaction,ongoing research,unassigned 3,3,0 3.1.1.23 Enteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=635796&form=6&db=m [Monoglyceride lipase insufficiency of the small intestine in chronic enteritis] diagnostic usage,ongoing research,unassigned 2,2,0 3.1.1.23 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25796567&form=6&db=m Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice. ongoing research,unassigned 4,0 3.1.1.23 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25796567&form=6&db=m Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice. ongoing research,unassigned 4,0 3.1.1.23 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26491015&form=6&db=m ?/? Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate. causal interaction,unassigned 4,0 3.1.1.23 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33672787&form=6&db=m Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice. ongoing research,unassigned 2,0 3.1.1.23 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.1.23 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30446439&form=6&db=m Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17143303&form=6&db=m Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. unassigned - 3.1.1.23 Head Injuries, Closed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25492114&form=6&db=m Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. causal interaction,therapeutic application,unassigned 2,1,0 3.1.1.23 Head Injuries, Closed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25826320&form=6&db=m Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. causal interaction,therapeutic application,unassigned 2,1,0 3.1.1.23 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30431495&form=6&db=m Monoacylglycerol Lipase Inactivation by Using URB602 Mitigates Myocardial Damage in a Rat Model of Cardiac Arrest. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.1.1.23 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31095034&form=6&db=m Monoacylglycerol Lipase Inactivation by Using URB602 Mitigates Myocardial Damage in a Rat Model of Cardiac Arrest: Erratum. causal interaction,ongoing research,unassigned 1,2,0 3.1.1.23 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1142711&form=6&db=m Endogenous and postheparin monoglyceride hydrolase in plasma of patients with acute virus hepatitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.1.1.23 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450181&form=6&db=m Profiling of MicroRNA Targets Using Activity-Based Protein Profiling: Linking Enzyme Activity to MicroRNA-185 Function. causal interaction,unassigned 2,0 3.1.1.23 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20554481&form=6&db=m Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice Through Distinct Cannabinoid Receptor Mechanisms. therapeutic application,unassigned 4,0 3.1.1.23 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22749865&form=6&db=m The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 3.1.1.23 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25100669&form=6&db=m Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. unassigned - 3.1.1.23 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29540562&form=6&db=m Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy. ongoing research,therapeutic application,unassigned 2,3,0 3.1.1.23 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33826922&form=6&db=m Endogenous opioid and cannabinoid systems modulate the muscle pain: A pharmacological study into the peripheral site. causal interaction,therapeutic application,unassigned 2,4,0 3.1.1.23 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4475759&form=6&db=m [Post-heparin lipolytic activity. (III). Lipoprotein lipase and monoglyceride hydrolase activities on hyperlipemia and the organs responsible for their biosynthesis] ongoing research,unassigned 1,0 3.1.1.23 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6616028&form=6&db=m Post-heparin plasma hepatic triglyceride lipase and monoglyceride hydrolase activities in hyperlipemia induced by a sucrose rich diet. unassigned - 3.1.1.23 Hyperlipoproteinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1029300&form=6&db=m [Activity of endogenous monoglyceride hydrolase in healthy subjects and patients with type IV Fredricksoln's hyperlipoproteinemia] diagnostic usage,ongoing research,unassigned 3,2,0 3.1.1.23 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27086176&form=6&db=m Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. unassigned - 3.1.1.23 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4007766&form=6&db=m Effects of tiadenol and clofibrate on plasma post heparin lipolytic hepatic, extrahepatic and monoglyceride hydrolase activities in rats with hypertriglyceridemia induced by a sucrose rich diet. ongoing research,unassigned 3,0 3.1.1.23 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29496497&form=6&db=m Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke. ongoing research,therapeutic application,unassigned 2,1,0 3.1.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21076482&form=6&db=m Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.1.1.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801453&form=6&db=m Effects of the monoacylglycerol lipase inhibitor JZL184 on chickens infected with avian pathogenic Escherichia coli O78: A preliminary pharmacokinetic and infection study. ongoing research,therapeutic application,unassigned 3,1,0 3.1.1.23 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31249581&form=6&db=m Tapetal Expression of BnaC.MAGL8.a Causes Male Sterility in Arabidopsis. causal interaction,unassigned 1,0 3.1.1.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1256330&form=6&db=m [Clinical experience with a new method for the determination of monoglyceride lipase (author's transl)] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.1.1.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30442681&form=6&db=m Inhibition of monoacylglycerol lipase for the treatment of liver disease: tempting but still playing with fire. therapeutic application,unassigned 4,0 3.1.1.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742127&form=6&db=m Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease. ongoing research,unassigned 2,0 3.1.1.23 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.1.23 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076001&form=6&db=m Aberrant lipid metabolism as a therapeutic target in liver cancer. unassigned - 3.1.1.23 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357777&form=6&db=m [Effect of monoacylglycerol lipase with proliferation of MHCC97H human liver cancer cells in vivo]. ongoing research,unassigned 4,0 3.1.1.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33632876&form=6&db=m The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB1 Cannabinoid Receptor. unassigned - 3.1.1.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527428&form=6&db=m Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.1.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28681540&form=6&db=m Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.1.23 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25910421&form=6&db=m Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. ongoing research,unassigned 3,0 3.1.1.23 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28132223&form=6&db=m P007. Inhibition of monoacylglycerol lipase activity modulates the activation of brain structures relevant for migraine pathogenesis. therapeutic application,unassigned 1,0 3.1.1.23 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28816506&form=6&db=m Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine? ongoing research,therapeutic application,unassigned 4,1,0 3.1.1.23 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29740328&form=6&db=m Emerging Role of (Endo)Cannabinoids in Migraine. ongoing research,unassigned 1,0 3.1.1.23 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33530477&form=6&db=m Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.1.23 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32285169&form=6&db=m JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.1.1.23 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25298214&form=6&db=m A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis. therapeutic application,unassigned 4,0 3.1.1.23 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30295758&form=6&db=m 2-arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction. causal interaction,unassigned 1,0 3.1.1.23 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120746&form=6&db=m Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.1.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120746&form=6&db=m Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.1.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28681540&form=6&db=m Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.1.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363004&form=6&db=m Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.1.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33632876&form=6&db=m The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB1 Cannabinoid Receptor. unassigned - 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685433&form=6&db=m Identification of genes with altered expression in medullary breast cancer vs. ductal breast cancer and normal breast epithelia. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20079333&form=6&db=m Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. causal interaction,ongoing research,unassigned 2,3,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543155&form=6&db=m Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349814&form=6&db=m Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24633487&form=6&db=m The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress. ongoing research,unassigned 2,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24676249&form=6&db=m Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. causal interaction,therapeutic application,unassigned 3,3,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26216043&form=6&db=m Monoglyceride lipase: Structure and inhibitors. therapeutic application,unassigned 1,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27767105&form=6&db=m Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27809504&form=6&db=m Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884159&form=6&db=m Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-?B-mediated epithelial-mesenchymal transition. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193521&form=6&db=m Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28681540&form=6&db=m Expression of monoacylglycerol lipase as a marker of tumour invasion and progression in malignant melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29542183&form=6&db=m Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29962341&form=6&db=m Development of thiazole-5-carboxylate derivatives as selective inhibition of monoacylglycerol lipase as a target in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968710&form=6&db=m Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30696302&form=6&db=m Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30914306&form=6&db=m Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons. ongoing research,therapeutic application,unassigned 2,2,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31143113&form=6&db=m Modulation of the Endocannabinoid System as a Potential Anticancer Strategy. diagnostic usage,unassigned 1,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31357249&form=6&db=m Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer. causal interaction,ongoing research,unassigned 3,3,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31668797&form=6&db=m ?-Quinazolinonylalkyl aryl ureas as reversible inhibitors of monoacylglycerol lipase. therapeutic application,unassigned 2,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32054717&form=6&db=m The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain. ongoing research,therapeutic application,unassigned 4,4,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32285169&form=6&db=m JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322464&form=6&db=m Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders. causal interaction,unassigned 3,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32376875&form=6&db=m Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363004&form=6&db=m Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.1.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34527428&form=6&db=m Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.1.23 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30067909&form=6&db=m Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354159&form=6&db=m Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders. causal interaction,therapeutic application,unassigned 3,1,0 3.1.1.23 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25393148&form=6&db=m Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 3.1.1.23 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26791602&form=6&db=m The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. ongoing research,therapeutic application,unassigned 3,2,0 3.1.1.23 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28857069&form=6&db=m The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. therapeutic application,unassigned 3,0 3.1.1.23 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29503395&form=6&db=m Inhibition of 2-arachydonoylgycerol degradation attenuates orofacial neuropathic pain in trigeminal nerve-injured mice. ongoing research,therapeutic application,unassigned 3,1,0 3.1.1.23 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33729209&form=6&db=m Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain. therapeutic application,unassigned 4,0 3.1.1.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30978461&form=6&db=m Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.1.23 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354159&form=6&db=m Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders. causal interaction,therapeutic application,unassigned 3,1,0 3.1.1.23 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30696302&form=6&db=m Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31518130&form=6&db=m Design, Synthesis and Evaluation of 18F-labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. causal interaction,therapeutic application,unassigned 3,2,0 3.1.1.23 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32483456&form=6&db=m Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,3,0 3.1.1.23 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32824740&form=6&db=m CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. causal interaction,therapeutic application,unassigned 4,3,0 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26166819&form=6&db=m Monoacylglycerol lipase promotes Fc? receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines. unassigned - 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26565024&form=6&db=m Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26694017&form=6&db=m A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. unassigned - 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28261100&form=6&db=m Endocannabinoids: A Promising Impact for Traumatic Brain Injury. therapeutic application,unassigned 1,0 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751457&form=6&db=m 2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination. ongoing research,therapeutic application,unassigned 1,4,0 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29171003&form=6&db=m Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29498843&form=6&db=m Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. causal interaction,therapeutic application,unassigned 3,4,0 3.1.1.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31251974&form=6&db=m Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. causal interaction,unassigned 1,0 3.1.1.23 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.1.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543155&form=6&db=m Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.1.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22937137&form=6&db=m Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity. unassigned - 3.1.1.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26491015&form=6&db=m ?/? Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate. causal interaction,unassigned 4,0 3.1.1.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265576&form=6&db=m Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice. causal interaction,ongoing research,unassigned 2,2,0 3.1.1.23 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27501482&form=6&db=m Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain. ongoing research,unassigned 3,0 3.1.1.23 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31937359&form=6&db=m Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis. ongoing research,therapeutic application,unassigned 1,1,0 3.1.1.23 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32285169&form=6&db=m JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.1.1.23 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32285169&form=6&db=m JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.1.1.23 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27318096&form=6&db=m Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. causal interaction,therapeutic application,unassigned 3,3,0 3.1.1.23 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352424&form=6&db=m Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson's Disease. unassigned - 3.1.1.23 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23127915&form=6&db=m Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. ongoing research,therapeutic application,unassigned 2,4,0 3.1.1.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21802006&form=6&db=m Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.1.1.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25012825&form=6&db=m The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. causal interaction,ongoing research,unassigned 4,4,0 3.1.1.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31831821&form=6&db=m FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. unassigned - 3.1.1.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32285169&form=6&db=m JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.1.1.23 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30366666&form=6&db=m Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.1.1.23 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22270809&form=6&db=m Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase - Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology. therapeutic application,unassigned 2,0 3.1.1.23 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25796567&form=6&db=m Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice. ongoing research,unassigned 4,0 3.1.1.23 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29171003&form=6&db=m Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.1.1.23 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30317131&form=6&db=m Endocannabinoid-mediated modulation of Gq protein-coupled receptor mediates vascular hyporeactivity to nor-adrenaline during polymicrobial sepsis. ongoing research,unassigned 2,0 3.1.1.23 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29171003&form=6&db=m Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.1.1.23 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31171434&form=6&db=m Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy. therapeutic application,unassigned 3,0 3.1.1.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29496497&form=6&db=m Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke. ongoing research,therapeutic application,unassigned 2,1,0 3.1.1.23 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30047001&form=6&db=m Monoacylglycerol Lipase Inhibitor is Safe when Combined with Delayed r-tPA Administration in Treatment of Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.1.1.23 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34117788&form=6&db=m Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study. ongoing research,unassigned 1,0 3.1.1.23 Tourette Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34117788&form=6&db=m Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study. ongoing research,unassigned 1,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17784850&form=6&db=m Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20601476&form=6&db=m A monoacylglycerol lipase from Mycobacterium smegmatis Involved in bacterial cell interaction. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21076482&form=6&db=m Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21966416&form=6&db=m Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22405030&form=6&db=m Potential Selective Inhibitors against Rv0183 of Mycobacterium tuberculosis Targeting Host Lipid Metabolism. causal interaction,therapeutic application,unassigned 2,4,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23651298&form=6&db=m Enantioselective inhibition of microbial lipolytic enzymes by nonracemic monocyclic enolphosphonate analogues of cyclophostin. ongoing research,unassigned 3,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29174965&form=6&db=m IL-6 release of Rv0183 antigen-stimulated whole blood is a potential biomarker for active tuberculosis patients. therapeutic application,unassigned 4,0 3.1.1.23 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29895832&form=6&db=m The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 3.1.1.23 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14660630&form=6&db=m Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. unassigned -