3.1.1.106 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422431&form=6&db=m MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.1.106 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880585&form=6&db=m MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.1.106 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30619475&form=6&db=m Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.1.106 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921812&form=6&db=m Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.1.106 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32151005&form=6&db=m The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0 3.1.1.106 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257385&form=6&db=m MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.1.1.106 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034629&form=6&db=m MACROD2 expression predicts response to 5-FU-based chemotherapy in stage III colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 3.1.1.106 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880585&form=6&db=m MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.1.106 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237848&form=6&db=m MACROD2 deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.1.106 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921812&form=6&db=m Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.1.106 Congenital, Hereditary, and Neonatal Diseases and Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30619475&form=6&db=m Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.1.106 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975270&form=6&db=m Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.1.1.106 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27304844&form=6&db=m Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy. causal interaction,unassigned 4,0 3.1.1.106 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30343302&form=6&db=m High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women. diagnostic usage,unassigned 3,0 3.1.1.106 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30619475&form=6&db=m Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.1.106 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31055587&form=6&db=m Intragenic Deletion in MACROD2: A Family with Complex Phenotypes Including Microcephaly, Intellectual Disability, Polydactyly, Renal and Pancreatic Malformations. diagnostic usage,unassigned 3,0 3.1.1.106 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31055587&form=6&db=m Intragenic Deletion in MACROD2: A Family with Complex Phenotypes Including Microcephaly, Intellectual Disability, Polydactyly, Renal and Pancreatic Malformations. diagnostic usage,unassigned 3,0 3.1.1.106 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422431&form=6&db=m MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.1.106 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257385&form=6&db=m MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23805207&form=6&db=m Two Distinct Categories of Focal Deletions in Cancer Genomes. ongoing research,therapeutic application,unassigned 2,1,0 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422431&form=6&db=m MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29410655&form=6&db=m MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria. causal interaction,unassigned 3,0 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29880585&form=6&db=m MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30076143&form=6&db=m MACROD2, an Original Cause of CIN? causal interaction,unassigned 4,0 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30619475&form=6&db=m Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921812&form=6&db=m Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32151005&form=6&db=m The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0 3.1.1.106 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257385&form=6&db=m MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.1.1.106 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32427867&form=6&db=m Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome. causal interaction,unassigned 4,0 3.1.1.106 o-acetyl-adp-ribose deacetylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257385&form=6&db=m MACROD2 deficiency promotes hepatocellular carcinoma growth and metastasis by activating GSK-3?/?-catenin signaling. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.1.1.106 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30619475&form=6&db=m Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.1.106 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33624934&form=6&db=m Association of MACROD2 gene variants with obesity and physical activity in a Korean population. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.1.1.106 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33191407&form=6&db=m Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site. ongoing research,therapeutic application,unassigned 2,1,0 3.1.1.106 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30343302&form=6&db=m High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women. diagnostic usage,unassigned 3,0 3.1.1.106 Polydactyly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31055587&form=6&db=m Intragenic Deletion in MACROD2: A Family with Complex Phenotypes Including Microcephaly, Intellectual Disability, Polydactyly, Renal and Pancreatic Malformations. diagnostic usage,unassigned 3,0 3.1.1.106 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26189108&form=6&db=m Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients. causal interaction,unassigned 1,0 3.1.1.106 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33954334&form=6&db=m PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance. therapeutic application,unassigned 1,0 3.1.1.106 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33191407&form=6&db=m Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site. ongoing research,therapeutic application,unassigned 2,1,0