2.8.2.29 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12036446&form=6&db=m Down-regulation of Gal 3-O-sulfotransferase-2 (Gal3ST-2) expression in human colonic non-mucinous adenocarcinoma. causal interaction,ongoing research,unassigned 3,2,0 2.8.2.29 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31407253&form=6&db=m CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients. diagnostic usage,ongoing research,unassigned 4,3,0 2.8.2.29 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25842390&form=6&db=m HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.8.2.29 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527896&form=6&db=m Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.8.2.29 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19153192&form=6&db=m Analysis of DNA Methylation of Multiple Genes in Microdissected Cells From Formalin-fixed and Paraffin-embedded Tissues. diagnostic usage,ongoing research,unassigned 3,2,0 2.8.2.29 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24752740&form=6&db=m HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.8.2.29 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28618938&form=6&db=m Laboratory validation of formal concept analysis of the methylation status of microarray-detected genes in primary breast cancer. diagnostic usage,unassigned 4,0 2.8.2.29 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30360368&form=6&db=m The Pro-Tumoral Activity of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) in Breast Cancer MDA-MB-231 Cells Is Dependent on the Expression of Neuropilin-1. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.8.2.29 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33102470&form=6&db=m The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.8.2.29 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33417295&form=6&db=m Prognostic significance of hedgehog signaling network-related gene expression in breast cancer patients. causal interaction,diagnostic usage,unassigned 3,4,0 2.8.2.29 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265783&form=6&db=m Epigenetic inactivation of heparan sulfate (glucosamine) 3-o-sulfotransferase 2 in lung cancer and its role in tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.8.2.29 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24664101&form=6&db=m Correction: epigenetic inactivation of heparan sulfate (glucosamine) 3-o-sulfotransferase 2 in lung cancer and its role in tumorigenesis. causal interaction,therapeutic application,unassigned 1,1,0 2.8.2.29 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30221668&form=6&db=m Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.8.2.29 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19153192&form=6&db=m Analysis of DNA Methylation of Multiple Genes in Microdissected Cells From Formalin-fixed and Paraffin-embedded Tissues. diagnostic usage,ongoing research,unassigned 3,2,0 2.8.2.29 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265783&form=6&db=m Epigenetic inactivation of heparan sulfate (glucosamine) 3-o-sulfotransferase 2 in lung cancer and its role in tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.8.2.29 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19812376&form=6&db=m Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.8.2.29 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21750708&form=6&db=m Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors. diagnostic usage,unassigned 1,0 2.8.2.29 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34234457&form=6&db=m HS3ST2 and Its Related Molecules as Potential Biomarkers for Predicting Lymph Node Metastasis in Patients with Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.8.2.29 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31903950&form=6&db=m Possible role of hsa-miR-194-5p, via regulation of HS3ST2, in the pathogenesis of atopic dermatitis in children. ongoing research,unassigned 1,0 2.8.2.29 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30221668&form=6&db=m Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.8.2.29 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30221668&form=6&db=m Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.8.2.29 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22116385&form=6&db=m A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of D-glucosaminyl 3-O-sulfotransferase-3a. causal interaction,therapeutic application,unassigned 1,1,0 2.8.2.29 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16336986&form=6&db=m A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread. causal interaction,therapeutic application,unassigned 4,1,0 2.8.2.29 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25198553&form=6&db=m Methylation in the promoters of HS3ST2 and CCNA1 genes is associated with cervical cancer in Uygur women in Xinjiang. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 2.8.2.29 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265783&form=6&db=m Epigenetic inactivation of heparan sulfate (glucosamine) 3-o-sulfotransferase 2 in lung cancer and its role in tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.8.2.29 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24664101&form=6&db=m Correction: epigenetic inactivation of heparan sulfate (glucosamine) 3-o-sulfotransferase 2 in lung cancer and its role in tumorigenesis. causal interaction,therapeutic application,unassigned 1,1,0 2.8.2.29 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34234457&form=6&db=m HS3ST2 and Its Related Molecules as Potential Biomarkers for Predicting Lymph Node Metastasis in Patients with Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.8.2.29 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21750708&form=6&db=m Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors. diagnostic usage,unassigned 1,0 2.8.2.29 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34234457&form=6&db=m HS3ST2 and Its Related Molecules as Potential Biomarkers for Predicting Lymph Node Metastasis in Patients with Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527896&form=6&db=m Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644104&form=6&db=m Application of a methylation gene panel by quantitative PCR for lung cancers. causal interaction,diagnostic usage,unassigned 3,4,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17894941&form=6&db=m Evaluation of candidate methylation markers to detect cervical neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19750229&form=6&db=m A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms. diagnostic usage,unassigned 1,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20098741&form=6&db=m Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. diagnostic usage,unassigned 3,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21750708&form=6&db=m Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors. diagnostic usage,unassigned 1,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22532293&form=6&db=m Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients. diagnostic usage,ongoing research,unassigned 4,3,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25703026&form=6&db=m The role of miR-100-mediated Notch pathway in apoptosis of gastric tumor cells. causal interaction,unassigned 3,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29547633&form=6&db=m The heparan sulfate 3-O-sulfotransferases (HS3ST) 2, 3B and 4 enhance proliferation and survival in breast cancer MDA-MB-231 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29732534&form=6&db=m Epigenetic loss of heparan sulfate 3-O-sulfation sensitizes ovarian carcinoma to oncogenic signals and predicts prognosis. diagnostic usage,therapeutic application,unassigned 1,4,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30221668&form=6&db=m Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31249810&form=6&db=m The Emerging Roles of Heparan Sulfate 3-O-Sulfotransferases in Cancer. causal interaction,therapeutic application,unassigned 1,1,0 2.8.2.29 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33173602&form=6&db=m GLAD-PCR Assay of R(5mC)GY Sites in the Regulatory Region of Tumor-Suppressor Genes Associated with Gastric Cancer. causal interaction,unassigned 2,0 2.8.2.29 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29732534&form=6&db=m Epigenetic loss of heparan sulfate 3-O-sulfation sensitizes ovarian carcinoma to oncogenic signals and predicts prognosis. diagnostic usage,therapeutic application,unassigned 1,4,0 2.8.2.29 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527896&form=6&db=m Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.8.2.29 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26769141&form=6&db=m High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.8.2.29 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31407253&form=6&db=m CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients. diagnostic usage,ongoing research,unassigned 4,3,0 2.8.2.29 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33173602&form=6&db=m GLAD-PCR Assay of R(5mC)GY Sites in the Regulatory Region of Tumor-Suppressor Genes Associated with Gastric Cancer. causal interaction,unassigned 2,0 2.8.2.29 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25842390&form=6&db=m HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.8.2.29 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27586786&form=6&db=m Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 2.8.2.29 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17894941&form=6&db=m Evaluation of candidate methylation markers to detect cervical neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.8.2.29 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25198553&form=6&db=m Methylation in the promoters of HS3ST2 and CCNA1 genes is associated with cervical cancer in Uygur women in Xinjiang. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0