2.7.11.23 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671421&form=6&db=m HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852730&form=6&db=m CTIP2 is a negative regulator of P-TEFb. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30230450&form=6&db=m [P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets]. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766667&form=6&db=m Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. therapeutic application,unassigned 4,0 2.7.11.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19024322&form=6&db=m [Effects of hnRNP B1 on DNA-PK activity, cell cycle and apoptosis in human lung adenocarcinoma cell line A549] diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19923078&form=6&db=m [Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radiosensitivity] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.7.11.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24675500&form=6&db=m Mechanisms underlying regulation of cell cycle and apoptosis by hnRNP B1 in human lung adenocarcinoma A549 cells. ongoing research,unassigned 4,0 2.7.11.23 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31068966&form=6&db=m P-TEFb Regulates Transcriptional Activation in Non-coding RNA Genes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.7.11.23 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25092825&form=6&db=m Molecular markers of carcinogenesis for risk stratification of individuals with colorectal polyps: a case-control study. causal interaction,diagnostic usage,unassigned 2,4,0 2.7.11.23 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321613&form=6&db=m Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. therapeutic application,unassigned 2,0 2.7.11.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23566654&form=6&db=m DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease. diagnostic usage,unassigned 2,0 2.7.11.23 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27376156&form=6&db=m DNA-PK Deficiency in Alzheimer's Disease. causal interaction,unassigned 4,0 2.7.11.23 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964778&form=6&db=m An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation. ongoing research,unassigned 3,0 2.7.11.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25441643&form=6&db=m DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25692509&form=6&db=m Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30233855&form=6&db=m Oxidative damage and DNA damage in lungs of an ovalbumin-induced asthmatic murine model. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952587&form=6&db=m IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10341340&form=6&db=m [Cell cycle regulation after exposure to ionizing radiation] causal interaction,unassigned 3,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446957&form=6&db=m Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473346&form=6&db=m Replication protein A (RPA): the eukaryotic SSB. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731442&form=6&db=m Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12228248&form=6&db=m Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. unassigned - 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12234250&form=6&db=m Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16293233&form=6&db=m Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510557&form=6&db=m Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells. unassigned - 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16945145&form=6&db=m Tying the loose ends together in DNA double strand break repair with 53BP1. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17371003&form=6&db=m Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. therapeutic application,unassigned 4,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20888899&form=6&db=m Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK. causal interaction,unassigned 1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245310&form=6&db=m Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705319&form=6&db=m Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase. causal interaction,unassigned 1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370278&form=6&db=m Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23462183&form=6&db=m Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit. unassigned - 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24220101&form=6&db=m DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003641&form=6&db=m Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25530717&form=6&db=m Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family. causal interaction,unassigned 1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32517381&form=6&db=m Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons. causal interaction,unassigned 2,0 2.7.11.23 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738447&form=6&db=m The promise of DNA damage response inhibitors for the treatment of glioblastoma. causal interaction,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8657148&form=6&db=m Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8808686&form=6&db=m The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8988043&form=6&db=m DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9000041&form=6&db=m Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9200331&form=6&db=m Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288850&form=6&db=m Molecular aspects of cellular responses to radiotherapy. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9375373&form=6&db=m DNA-dependent protein kinase. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9583675&form=6&db=m Functional role for the c-Abl tyrosine kinase in meiosis I. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766667&form=6&db=m Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. therapeutic application,unassigned 4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806612&form=6&db=m Monitoring and signaling of radiation-induced damage in mammalian cells. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815794&form=6&db=m Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10064605&form=6&db=m Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10717533&form=6&db=m Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10805749&form=6&db=m The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11080496&form=6&db=m Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11279124&form=6&db=m Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. therapeutic application,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507241&form=6&db=m Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731442&form=6&db=m Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751435&form=6&db=m Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065055&form=6&db=m Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12228248&form=6&db=m Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12234250&form=6&db=m Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660252&form=6&db=m Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12919958&form=6&db=m ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13678345&form=6&db=m DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway. ongoing research,unassigned 4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14617796&form=6&db=m Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity. therapeutic application,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14872059&form=6&db=m Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14966265&form=6&db=m ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164794&form=6&db=m Role of DNA-dependent protein kinase in the process of radiation-induced aberration formation. ongoing research,unassigned 4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574327&form=6&db=m A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661267&form=6&db=m DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867362&form=6&db=m Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15941674&form=6&db=m DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014356&form=6&db=m PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199871&form=6&db=m Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16221682&form=6&db=m mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394637&form=6&db=m p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure. causal interaction,unassigned 3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483312&form=6&db=m Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. ongoing research,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16523492&form=6&db=m Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. causal interaction,unassigned 3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16651405&form=6&db=m DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex. causal interaction,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909103&form=6&db=m ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17320201&form=6&db=m Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts. causal interaction,unassigned 4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17371003&form=6&db=m Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. therapeutic application,unassigned 4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875720&form=6&db=m Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17997386&form=6&db=m Targeting phosphoinositide 3-kinase: moving towards therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18066095&form=6&db=m Targeted cancer therapies based on the inhibition of DNA strand break repair. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172300&form=6&db=m DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202016&form=6&db=m Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18644470&form=6&db=m DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18796370&form=6&db=m Role of CHK2 in cancer development. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18845680&form=6&db=m Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19057578&form=6&db=m DNA-PK suppresses a p53-independent apoptotic response to DNA damage. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336520&form=6&db=m Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation. ongoing research,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19435836&form=6&db=m Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19580482&form=6&db=m Dose response of gamma rays and iron nuclei for induction of chromosomal aberrations in normal and repair-deficient cell lines. ongoing research,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19793861&form=6&db=m The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406630&form=6&db=m Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20588260&form=6&db=m Therapeutic effect of sodium iodide symporter gene therapy combined with external beam radiotherapy and targeted drugs that inhibit DNA repair. therapeutic application,unassigned 3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660628&form=6&db=m DNA damage signaling in response to double-strand breaks during mitosis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814172&form=6&db=m Involvement of DNA-PK and ATM in radiation- and heat-induced DNA damage recognition and apoptotic cell death. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21270755&form=6&db=m DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487018&form=6&db=m The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21546556&form=6&db=m DNA-dependent protein kinase and Ataxia Telangiectasia Mutated (ATM) promote cell survival in response to NK314, a topoisomerase II? inhibitor. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21742970&form=6&db=m Repair of Chromosomal RAG-Mediated DNA Breaks by Mutant RAG Proteins Lacking Phosphatidylinositol 3-Like Kinase Consensus Phosphorylation Sites. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21824916&form=6&db=m Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22173400&form=6&db=m Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4(+) T cells. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22366497&form=6&db=m Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22451927&form=6&db=m Role of the translationally controlled tumor protein in DNA damage sensing and repair. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627294&form=6&db=m Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling. therapeutic application,unassigned 3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22797063&form=6&db=m DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22977523&form=6&db=m Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23382544&form=6&db=m The Ataxia Telangiectasia mutated kinase controls Ig? allelic exclusion by inhibiting secondary V?-to-J? rearrangements. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620287&form=6&db=m Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24218548&form=6&db=m Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24662822&form=6&db=m DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25002126&form=6&db=m Elevated DNA damage response in pancreatic cancer. ongoing research,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25010594&form=6&db=m Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017126&form=6&db=m Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483091&form=6&db=m Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25585815&form=6&db=m The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25947085&form=6&db=m The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26338538&form=6&db=m The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498210&form=6&db=m Chemical inhibition of DNA repair kinases as a promising tool in oncology. therapeutic application,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26586426&form=6&db=m Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26595742&form=6&db=m The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26631035&form=6&db=m Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma. therapeutic application,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26674120&form=6&db=m ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26779995&form=6&db=m A flow cytometry assay that measures cellular sensitivity to DNA-damaging agents, customized for clinical routine laboratories. diagnostic usage,unassigned 3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26843428&form=6&db=m The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26848527&form=6&db=m DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27100743&form=6&db=m A critical role for topoisomerase IIb and DNA double strand breaks in transcription. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27733551&form=6&db=m Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27829214&form=6&db=m PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654064&form=6&db=m Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28746371&form=6&db=m Ionizing radiation response of primary normal human lens epithelial cells. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28851987&form=6&db=m P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28952912&form=6&db=m Measurement of DNA-Dependent Protein Kinase Phosphorylation Using Flow Cytometry Provides a Reliable Estimate of DNA Repair Capacity. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29126306&form=6&db=m The Future of Radiobiology. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30836860&form=6&db=m PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30850485&form=6&db=m Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30964658&form=6&db=m Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. causal interaction,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31428617&form=6&db=m Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism. causal interaction,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31841199&form=6&db=m PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32001024&form=6&db=m Transcriptional Regulation at DSBs: Mechanisms and Consequences. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32517381&form=6&db=m Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons. causal interaction,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32601814&form=6&db=m Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32883016&form=6&db=m Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. therapeutic application,unassigned 1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33158243&form=6&db=m Improving Radiation Response in Glioblastoma Using ECO/siRNA Nanoparticles Targeting DNA Damage Repair. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738447&form=6&db=m The promise of DNA damage response inhibitors for the treatment of glioblastoma. causal interaction,unassigned 2,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33860085&form=6&db=m It takes three to the DNA damage response tango. unassigned - 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33901880&form=6&db=m Far-infrared irradiation inhibits breast cancer cell proliferation independently of DNA damage through increased nuclear Ca2+/calmodulin binding modulated-activation of checkpoint kinase 2. causal interaction,unassigned 4,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34400266&form=6&db=m Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.23 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34428039&form=6&db=m BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies. therapeutic application,unassigned 2,0 2.7.11.23 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27574181&form=6&db=m Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation. therapeutic application,unassigned 1,0 2.7.11.23 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273464&form=6&db=m DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity. causal interaction,unassigned 4,0 2.7.11.23 Blast Crisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493325&form=6&db=m [Gene of DNA-dependent protein kinase catalylic subunit in chronic myeloid leukemia] diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.23 Bone Marrow Failure Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29459202&form=6&db=m Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400681&form=6&db=m Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences. ongoing research,unassigned 4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10813395&form=6&db=m Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction. causal interaction,unassigned 1,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196174&form=6&db=m Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388662&form=6&db=m A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000400&form=6&db=m The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. causal interaction,diagnostic usage,unassigned 3,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16293233&form=6&db=m Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505093&form=6&db=m Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16959964&form=6&db=m The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation. causal interaction,unassigned 4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17593081&form=6&db=m The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase. diagnostic usage,unassigned 4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786349&form=6&db=m Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982634&form=6&db=m Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20111054&form=6&db=m Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193758&form=6&db=m DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20219974&form=6&db=m Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22815474&form=6&db=m Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24292814&form=6&db=m DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25053741&form=6&db=m LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. therapeutic application,unassigned 1,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25801233&form=6&db=m Changes in the response of MCF-7 cells to ionizing radiation after the combination of ATM and DNA-PK inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26848527&form=6&db=m DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression. causal interaction,unassigned 1,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27507046&form=6&db=m RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034453&form=6&db=m DNA damage repair in breast cancer and its therapeutic implications. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28471392&form=6&db=m Taking a Bad Turn: Compromised DNA Damage Response in Leukemia. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31983282&form=6&db=m DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32520633&form=6&db=m HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32628111&form=6&db=m PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33074046&form=6&db=m Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in ?/? ratio. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.7.11.23 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33385162&form=6&db=m Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.23 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8086496&form=6&db=m Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9398855&form=6&db=m Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. unassigned - 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9990036&form=6&db=m Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121239&form=6&db=m Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. causal interaction,unassigned 4,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532879&form=6&db=m High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731412&form=6&db=m Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis. ongoing research,unassigned 2,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15551138&form=6&db=m Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964549&form=6&db=m Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786356&form=6&db=m The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18249148&form=6&db=m A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. causal interaction,unassigned 4,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731906&form=6&db=m [The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.] causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22488152&form=6&db=m LARP7 is a potential tumor suppressor gene in gastric cancer. causal interaction,unassigned 3,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26107252&form=6&db=m Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. therapeutic application,unassigned 1,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29616226&form=6&db=m XPD-The Lynchpin of NER: Molecule, Gene, Polymorphisms, and Role in Colorectal Carcinogenesis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31037337&form=6&db=m Multiple roles of CTDK-I throughout the cell. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.23 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32543350&form=6&db=m Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10211098&form=6&db=m DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104569&form=6&db=m Expression of Ku70 correlates with survival in carcinoma of the cervix. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133044&form=6&db=m Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation. ongoing research,unassigned 4,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304695&form=6&db=m Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. ongoing research,unassigned 4,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11383649&form=6&db=m Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12658736&form=6&db=m Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13678345&form=6&db=m DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway. ongoing research,unassigned 4,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14556663&form=6&db=m Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15551138&form=6&db=m Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16138421&form=6&db=m The effect of wortmannin on radiation-induced chromosome aberration formation in the radioresistant tumor cell line WiDr. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16827151&form=6&db=m Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavity. ongoing research,unassigned 3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18386192&form=6&db=m Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672258&form=6&db=m Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24187467&form=6&db=m Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25735090&form=6&db=m [Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma]. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27643582&form=6&db=m Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28331416&form=6&db=m DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490091&form=6&db=m Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828418&form=6&db=m Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.23 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33074046&form=6&db=m Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in ?/? ratio. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.7.11.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021771&form=6&db=m DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27160694&form=6&db=m NU7441 Enhances the Radiosensitivity of Liver Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31194786&form=6&db=m Targeting DNA-dependent protein kinase sensitizes hepatocellular carcinoma cells to proton beam irradiation through apoptosis induction. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33020270&form=6&db=m Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors. therapeutic application,unassigned 4,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350043&form=6&db=m DNA-dependent protein kinase is inhibited by trifluoperazine. ongoing research,unassigned 2,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12438258&form=6&db=m Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines. ongoing research,unassigned 4,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21306678&form=6&db=m [The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575478&form=6&db=m [Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer]. unassigned - 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24411611&form=6&db=m Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells. ongoing research,unassigned 3,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26553138&form=6&db=m Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28331416&form=6&db=m DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29287602&form=6&db=m Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation. therapeutic application,unassigned 4,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34462666&form=6&db=m Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.23 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9989526&form=6&db=m DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12658736&form=6&db=m Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490091&form=6&db=m Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828418&form=6&db=m Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.23 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33133138&form=6&db=m Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. therapeutic application,unassigned 4,0 2.7.11.23 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15551138&form=6&db=m Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695656&form=6&db=m Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627702&form=6&db=m Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. causal interaction,unassigned 1,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14749500&form=6&db=m Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9. causal interaction,unassigned 1,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16959964&form=6&db=m The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation. causal interaction,unassigned 4,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17169370&form=6&db=m Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459355&form=6&db=m Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy. causal interaction,unassigned 3,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671421&form=6&db=m HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18655042&form=6&db=m RNA-driven cyclin-dependent kinase regulation: when CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18662700&form=6&db=m The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19246988&form=6&db=m 7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor. unassigned - 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443839&form=6&db=m Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1. ongoing research,unassigned 2,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22377309&form=6&db=m [Misregulation of P-TEFb activity: pathological consequences]. causal interaction,unassigned 2,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23252711&form=6&db=m Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852730&form=6&db=m CTIP2 is a negative regulator of P-TEFb. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075058&form=6&db=m P-TEFb as A Promising Therapeutic Target. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7664335&form=6&db=m The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980491&form=6&db=m Transcription by RNA polymerase II: a process linked to DNA repair. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8652557&form=6&db=m Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8855246&form=6&db=m Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9118947&form=6&db=m Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. causal interaction,unassigned 4,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9173976&form=6&db=m The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9774388&form=6&db=m RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62. diagnostic usage,therapeutic application,unassigned 1,2,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10660593&form=6&db=m TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair. causal interaction,unassigned 2,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10786832&form=6&db=m Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome. therapeutic application,unassigned 2,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872452&form=6&db=m Transcription elongation and human disease. ongoing research,unassigned 2,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221129&form=6&db=m DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509240&form=6&db=m Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115885&form=6&db=m Analysis of U1 small nuclear RNA interaction with cyclin H. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246722&form=6&db=m Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16329169&form=6&db=m Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome. therapeutic application,unassigned 2,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466625&form=6&db=m XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18510924&form=6&db=m XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429618&form=6&db=m Transcription factor IIH - the protein complex with multiple functions. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965540&form=6&db=m TFIIH is an elongation factor of RNA polymerase I. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22187342&form=6&db=m Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). unassigned - 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24781187&form=6&db=m Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth. unassigned - 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016283&form=6&db=m TTDA: Big impact of a small protein. causal interaction,unassigned 2,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25058334&form=6&db=m UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells. unassigned - 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25620205&form=6&db=m TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription. unassigned - 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26245904&form=6&db=m Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation. unassigned - 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27805905&form=6&db=m Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation. causal interaction,unassigned 2,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28902838&form=6&db=m The cryo-electron microscopy structure of human transcription factor IIH. causal interaction,unassigned 3,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798933&form=6&db=m TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair. unassigned - 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30894545&form=6&db=m Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31110295&form=6&db=m Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. therapeutic application,unassigned 1,0 2.7.11.23 Cockayne Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31963603&form=6&db=m Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases. causal interaction,unassigned 3,0 2.7.11.23 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628243&form=6&db=m Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. unassigned - 2.7.11.23 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27690730&form=6&db=m Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254745&form=6&db=m Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18386192&form=6&db=m Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27524110&form=6&db=m The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. therapeutic application,unassigned 1,0 2.7.11.23 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075058&form=6&db=m P-TEFb as A Promising Therapeutic Target. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.23 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31183407&form=6&db=m Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. ongoing research,unassigned 1,0 2.7.11.23 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20618343&form=6&db=m Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8). therapeutic application,unassigned 4,0 2.7.11.23 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22999307&form=6&db=m Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.23 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28467930&form=6&db=m DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.23 DNA Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098118&form=6&db=m A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus. causal interaction,unassigned 1,0 2.7.11.23 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29144413&form=6&db=m Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle. causal interaction,unassigned 1,0 2.7.11.23 Equine Infectious Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964778&form=6&db=m An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation. ongoing research,unassigned 3,0 2.7.11.23 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741736&form=6&db=m DNA-dependent protein kinase activity correlates with Ku70 expression and radiation sensitivity in esophageal cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.23 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865228&form=6&db=m Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.7.11.23 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370278&form=6&db=m Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest. therapeutic application,unassigned 1,0 2.7.11.23 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26603260&form=6&db=m Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. ongoing research,unassigned 3,0 2.7.11.23 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12210059&form=6&db=m Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.7.11.23 Frontotemporal Lobar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34130995&form=6&db=m DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. unassigned - 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7613092&form=6&db=m TFIIH: a link between transcription, DNA repair and cell cycle regulation. unassigned - 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10023043&form=6&db=m Genomic organization and promoter characterization of two human UHS keratin genes. causal interaction,unassigned 1,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11955452&form=6&db=m XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha. unassigned - 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15354295&form=6&db=m RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila. causal interaction,unassigned 3,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15988019&form=6&db=m Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations. therapeutic application,unassigned 1,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952069&form=6&db=m Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934020&form=6&db=m Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients. causal interaction,unassigned 2,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20016270&form=6&db=m The long unwinding road: XPB and XPD helicases in damaged DNA opening. therapeutic application,unassigned 1,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429618&form=6&db=m Transcription factor IIH - the protein complex with multiple functions. therapeutic application,unassigned 1,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26996949&form=6&db=m GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy. causal interaction,unassigned 2,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28902838&form=6&db=m The cryo-electron microscopy structure of human transcription factor IIH. causal interaction,unassigned 3,0 2.7.11.23 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33860085&form=6&db=m It takes three to the DNA damage response tango. unassigned - 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10327072&form=6&db=m The ATM protein is required for sustained activation of NF-kappaB following DNA damage. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629611&form=6&db=m Complementation of the radiosensitive M059J cell line. unassigned - 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304695&form=6&db=m Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. ongoing research,unassigned 4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065055&form=6&db=m Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12556332&form=6&db=m Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J. ongoing research,unassigned 4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15493013&form=6&db=m Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15711934&form=6&db=m Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16434448&form=6&db=m The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor. ongoing research,unassigned 4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108124&form=6&db=m Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638872&form=6&db=m Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19144640&form=6&db=m DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif. ongoing research,unassigned 3,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19198648&form=6&db=m Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. ongoing research,unassigned 2,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19933707&form=6&db=m DNA-dependent protein kinase (DNA-PK)-deficient human glioblastoma cells are preferentially sensitized by Zebularine. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193758&form=6&db=m DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20380575&form=6&db=m Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20711232&form=6&db=m Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775006&form=6&db=m Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22298787&form=6&db=m SAPSR1 is a bidentate anchor for targeting protein phosphatase-6 to DNA-PK. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22542809&form=6&db=m Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22770110&form=6&db=m Novel survivin inhibitor YM155 elicits cytotoxicity in glioblastoma cell lines with normal or deficiency DNA-dependent protein kinase activity. ongoing research,unassigned 2,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23722536&form=6&db=m Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24186206&form=6&db=m IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25441643&form=6&db=m DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25823028&form=6&db=m CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-?B pathway in multidrug-resistant glioblastoma cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27593924&form=6&db=m CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-?B pathway in multidrug-resistant glioblastoma cells in vitro. ongoing research,unassigned 2,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29549168&form=6&db=m The DNA-PK inhibitor VX-984 enhances the radiosensitivity of glioblastoma cells grown in vitro and as orthotopic xenografts. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31522595&form=6&db=m The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. ongoing research,unassigned 3,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31583565&form=6&db=m Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32038792&form=6&db=m Activation Mechanism of Protein Kinase B by DNA-dependent Protein Kinase Involved in the DNA Repair System. causal interaction,unassigned 1,0 2.7.11.23 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34193614&form=6&db=m Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585574&form=6&db=m Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7855602&form=6&db=m Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. unassigned - 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670824&form=6&db=m DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. ongoing research,unassigned 3,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9052673&form=6&db=m Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity. ongoing research,unassigned 4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9705502&form=6&db=m DNA-PK is essential only for coding joint formation in V(D)J recombination. ongoing research,unassigned 3,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9716137&form=6&db=m DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. ongoing research,unassigned 4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9837719&form=6&db=m Ku70/Ku80 protein complex inhibits the binding of nucleotide excision repair proteins on linear DNA in vitro. ongoing research,unassigned 2,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022818&form=6&db=m Differential stability of the DNA-activated protein kinase catalytic subunit mRNA in human glioma cells. ongoing research,unassigned 4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10647823&form=6&db=m Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells. ongoing research,unassigned 2,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728683&form=6&db=m DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. ongoing research,unassigned 3,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11096417&form=6&db=m cDNA expression array analysis of DNA repair genes in human glioma cells that lack or express DNA-PK. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12691524&form=6&db=m Differential gene expression in human glioma cells: correlation with presence or absence of DNA-dependent protein kinase. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555344&form=6&db=m Low and high LET radiation-induced apoptosis in M059J and M059K cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899829&form=6&db=m Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044996&form=6&db=m [Correlation of DNA-PK activity with anti-cancer drug-sensitivity in human gliomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17596214&form=6&db=m Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. therapeutic application,unassigned 1,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18415044&form=6&db=m Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430698&form=6&db=m The role of autophagy in sensitizing malignant glioma cells to radiation therapy. causal interaction,unassigned 4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20380575&form=6&db=m Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21998290&form=6&db=m Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells. ongoing research,unassigned 2,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22073281&form=6&db=m Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29415883&form=6&db=m Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31583565&form=6&db=m Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.23 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34193614&form=6&db=m Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.23 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571209&form=6&db=m The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.23 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26603260&form=6&db=m Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. ongoing research,unassigned 3,0 2.7.11.23 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33133138&form=6&db=m Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. therapeutic application,unassigned 4,0 2.7.11.23 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8855220&form=6&db=m Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. unassigned - 2.7.11.23 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9488473&form=6&db=m Hepatitis B virus pX targets TFIIB in transcription coactivation. therapeutic application,unassigned 1,0 2.7.11.23 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278765&form=6&db=m Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue. ongoing research,unassigned 2,0 2.7.11.23 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14680837&form=6&db=m Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts. unassigned - 2.7.11.23 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21375739&form=6&db=m Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH. unassigned - 2.7.11.23 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19467273&form=6&db=m Hepatitis C virus-core protein facilitates the degradation of Ku70 and reduces DNA-PK activity in hepatocytes. unassigned - 2.7.11.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592583&form=6&db=m The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7935417&form=6&db=m Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8892865&form=6&db=m Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9847370&form=6&db=m Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.23 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029222&form=6&db=m Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb. ongoing research,unassigned 3,0 2.7.11.23 Herpesviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144993&form=6&db=m Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10661406&form=6&db=m Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16959964&form=6&db=m The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation. causal interaction,unassigned 4,0 2.7.11.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17576689&form=6&db=m Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR. ongoing research,unassigned 4,0 2.7.11.23 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239456&form=6&db=m The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9032269&form=6&db=m Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle. unassigned - 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214634&form=6&db=m KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10660692&form=6&db=m [DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation] causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10945500&form=6&db=m Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11805111&form=6&db=m Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. causal interaction,unassigned 1,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12015322&form=6&db=m Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin. causal interaction,unassigned 1,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592499&form=6&db=m The life and death of DNA-PK. therapeutic application,unassigned 1,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304914&form=6&db=m Transcription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824372&form=6&db=m P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31374204&form=6&db=m Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. causal interaction,unassigned 1,0 2.7.11.23 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23300697&form=6&db=m Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice. therapeutic application,unassigned 1,0 2.7.11.23 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10644710&form=6&db=m Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.23 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115885&form=6&db=m Analysis of U1 small nuclear RNA interaction with cyclin H. therapeutic application,unassigned 1,0 2.7.11.23 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167068&form=6&db=m Suppression of UV-induced apoptosis by the human DNA repair protein XPG. causal interaction,unassigned 2,0 2.7.11.23 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19114557&form=6&db=m An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. unassigned - 2.7.11.23 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19681155&form=6&db=m New clinico-genetic classification of trichothiodystrophy. causal interaction,unassigned 3,0 2.7.11.23 Ichthyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24134817&form=6&db=m Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms. therapeutic application,unassigned 2,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8892865&form=6&db=m Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9847370&form=6&db=m Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10377393&form=6&db=m Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872452&form=6&db=m Transcription elongation and human disease. ongoing research,unassigned 2,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238839&form=6&db=m Computational analysis of retrovirus-induced scid cell death. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14980221&form=6&db=m TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163725&form=6&db=m Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20551309&form=6&db=m P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes. therapeutic application,unassigned 2,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20618343&form=6&db=m Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8). therapeutic application,unassigned 4,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21167544&form=6&db=m XPB mediated retroviral cDNA degradation coincides with entry to the nucleus. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21453127&form=6&db=m Activation of P-TEFb (CycT1/CDK9) at sites of dual HIV/TB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime. therapeutic application,unassigned 1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22999307&form=6&db=m Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23739328&form=6&db=m HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24701579&form=6&db=m Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity. causal interaction,unassigned 1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26157124&form=6&db=m Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities. unassigned - 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27982097&form=6&db=m Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30337542&form=6&db=m DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30428360&form=6&db=m DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529192&form=6&db=m Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842317&form=6&db=m Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32430362&form=6&db=m Different views of the dynamic landscape covered by the 5'-hairpin of the 7SK small nuclear RNA. causal interaction,unassigned 4,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32796076&form=6&db=m Baculovirus Transduction in Mammalian Cells Is Affected by the Production of Type I and III Interferons, Which Is Mediated Mainly by the cGAS-STING Pathway. unassigned - 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32824372&form=6&db=m Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144993&form=6&db=m Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.23 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31034753&form=6&db=m Evidence for a novel mechanism of influenza A virus host adaptation modulated by PB2-627. unassigned - 2.7.11.23 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28515340&form=6&db=m Turning back the clock. causal interaction,unassigned 1,0 2.7.11.23 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28931940&form=6&db=m BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene. unassigned - 2.7.11.23 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22718820&form=6&db=m Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF-?B Activation. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872452&form=6&db=m Transcription elongation and human disease. ongoing research,unassigned 2,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11086175&form=6&db=m Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin. ongoing research,unassigned 3,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010369&form=6&db=m A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15978944&form=6&db=m Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441731&form=6&db=m Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058849&form=6&db=m A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188661&form=6&db=m Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors. causal interaction,unassigned 1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20305087&form=6&db=m A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471949&form=6&db=m HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. therapeutic application,unassigned 1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21460034&form=6&db=m The super elongation complex (SEC) and MLL in development and disease. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21873227&form=6&db=m Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. therapeutic application,unassigned 1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21896721&form=6&db=m Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. therapeutic application,unassigned 1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22040967&form=6&db=m [Expression of DNA-dependent protein kinase catalylic subunit in adult acute leukemia and its significance]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22195968&form=6&db=m The little elongation complex regulates small nuclear RNA transcription. therapeutic application,unassigned 1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22366497&form=6&db=m Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127601&form=6&db=m ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair. therapeutic application,unassigned 1,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31253180&form=6&db=m Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.23 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108527&form=6&db=m DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.23 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393878&form=6&db=m Regulation of DNA-dependent protein kinase activity in leukemic cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.23 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581813&form=6&db=m Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9746757&form=6&db=m DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 2.7.11.23 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559621&form=6&db=m DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.7.11.23 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21270755&form=6&db=m DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.23 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493325&form=6&db=m [Gene of DNA-dependent protein kinase catalylic subunit in chronic myeloid leukemia] diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.23 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34372855&form=6&db=m Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.7.11.23 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058849&form=6&db=m A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872452&form=6&db=m Transcription elongation and human disease. ongoing research,unassigned 2,0 2.7.11.23 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32117773&form=6&db=m DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245486&form=6&db=m NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.23 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26338538&form=6&db=m The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26595742&form=6&db=m The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31838185&form=6&db=m The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by ?H2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells. ongoing research,unassigned 2,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11323390&form=6&db=m Reduced DNA-dependent protein kinase activity is associated with lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350043&form=6&db=m DNA-dependent protein kinase is inhibited by trifluoperazine. ongoing research,unassigned 2,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12438258&form=6&db=m Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines. ongoing research,unassigned 4,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21306678&form=6&db=m [The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575478&form=6&db=m [Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer]. unassigned - 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24411611&form=6&db=m Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells. ongoing research,unassigned 3,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26553138&form=6&db=m Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26762068&form=6&db=m [Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice]. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29287602&form=6&db=m Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation. therapeutic application,unassigned 4,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32477940&form=6&db=m M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414509&form=6&db=m Targeting DNA-PK overcomes acquired resistance to third-generation EGFR-TKI osimertinib in non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34462666&form=6&db=m Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.23 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7759997&form=6&db=m Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. causal interaction,unassigned 3,0 2.7.11.23 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786349&form=6&db=m Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 2.7.11.23 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23011604&form=6&db=m Protein predictive signatures for lymph node metastasis of gastric cancer. diagnostic usage,unassigned 3,0 2.7.11.23 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29080451&form=6&db=m Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. causal interaction,unassigned 1,0 2.7.11.23 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.7.11.23 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279407&form=6&db=m Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.23 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11222085&form=6&db=m Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.23 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279407&form=6&db=m Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.23 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.7.11.23 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15215044&form=6&db=m Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19149561&form=6&db=m Topological polar surface area: a useful descriptor in 2D-QSAR. therapeutic application,unassigned 3,0 2.7.11.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15273254&form=6&db=m Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27524110&form=6&db=m The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. therapeutic application,unassigned 1,0 2.7.11.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28775208&form=6&db=m A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies. therapeutic application,unassigned 3,0 2.7.11.23 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31480356&form=6&db=m Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.7.11.23 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17630775&form=6&db=m Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828418&form=6&db=m Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.23 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15215044&form=6&db=m Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28938651&form=6&db=m Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma. ongoing research,unassigned 2,0 2.7.11.23 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258103&form=6&db=m Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma. ongoing research,unassigned 2,0 2.7.11.23 Muscular Atrophy, Spinal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10673506&form=6&db=m Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. ongoing research,unassigned 2,0 2.7.11.23 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32286286&form=6&db=m Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity. therapeutic application,unassigned 3,0 2.7.11.23 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16029807&form=6&db=m Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,3 2.7.11.23 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17700973&form=6&db=m DNA-dependent protein kinase activity and radiosensitivity of nasopharyngeal carcinoma cell lines CNE1/CNE2. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29357787&form=6&db=m Knockdown of Annexin A1 Enhances Radioresistance and Inhibits Apoptosis in Nasopharyngeal Carcinoma. causal interaction,unassigned 3,0 2.7.11.23 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786349&form=6&db=m Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22807979&form=6&db=m Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23011604&form=6&db=m Protein predictive signatures for lymph node metastasis of gastric cancer. diagnostic usage,unassigned 3,0 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23765726&form=6&db=m The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25053741&form=6&db=m LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. therapeutic application,unassigned 1,0 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31395353&form=6&db=m DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828418&form=6&db=m Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.23 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32610116&form=6&db=m DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1406679&form=6&db=m Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899239&form=6&db=m Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247067&form=6&db=m Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. ongoing research,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585574&form=6&db=m Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7882984&form=6&db=m The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8291090&form=6&db=m DNA damage and the DNA-activated protein kinase. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8687116&form=6&db=m Xeroderma pigmentosum and molecular cloning of DNA repair genes. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9268364&form=6&db=m SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9375373&form=6&db=m DNA-dependent protein kinase. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581813&form=6&db=m Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685611&form=6&db=m Increased expression of DNA-dependent protein kinase confers resistance to adriamycin. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766667&form=6&db=m Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. therapeutic application,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806612&form=6&db=m Monitoring and signaling of radiation-induced damage in mammalian cells. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815794&form=6&db=m Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10072165&form=6&db=m The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10214916&form=6&db=m Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10330147&form=6&db=m Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription. therapeutic application,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10341340&form=6&db=m [Cell cycle regulation after exposure to ionizing radiation] causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10467415&form=6&db=m Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556596&form=6&db=m Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571209&form=6&db=m The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10629611&form=6&db=m Complementation of the radiosensitive M059J cell line. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10660692&form=6&db=m [DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation] causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872452&form=6&db=m Transcription elongation and human disease. ongoing research,unassigned 2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10945500&form=6&db=m Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11096417&form=6&db=m cDNA expression array analysis of DNA repair genes in human glioma cells that lack or express DNA-PK. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104569&form=6&db=m Expression of Ku70 correlates with survival in carcinoma of the cervix. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11239393&form=6&db=m Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11383649&form=6&db=m Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418067&form=6&db=m Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J. ongoing research,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11431468&form=6&db=m Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11642303&form=6&db=m Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704662&form=6&db=m Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex. therapeutic application,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867233&form=6&db=m DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168870&form=6&db=m DNA-dependent protein kinase in leukaemia cells and correlation with drug sensitivity. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12210059&form=6&db=m Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359753&form=6&db=m Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388662&form=6&db=m A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12438258&form=6&db=m Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines. ongoing research,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12528889&form=6&db=m The role of nitric oxide in cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626129&form=6&db=m Biologic characterization of a secondary glioblastoma with extracranial progression and systemic metastasis. causal interaction,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12658736&form=6&db=m Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12691524&form=6&db=m Differential gene expression in human glioma cells: correlation with presence or absence of DNA-dependent protein kinase. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713733&form=6&db=m Differential DNA binding of Ku antigen determines its involvement in DNA replication. ongoing research,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713809&form=6&db=m Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926987&form=6&db=m Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555350&form=6&db=m Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14556663&form=6&db=m Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14599773&form=6&db=m Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14661061&form=6&db=m SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707266&form=6&db=m DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751090&form=6&db=m Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069205&form=6&db=m Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15184871&form=6&db=m Reduced DNA-dependent protein kinase activity in two cell lines derived from adult cancer patients with late radionecrosis. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15215044&form=6&db=m Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15221960&form=6&db=m Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor. diagnostic usage,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254745&form=6&db=m Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272235&form=6&db=m Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15273254&form=6&db=m Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15286704&form=6&db=m Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15493013&form=6&db=m Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15533760&form=6&db=m Molecular mechanisms of platinum resistance: still searching for the Achilles' heel. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15658870&form=6&db=m Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15678607&form=6&db=m Rare diseases provide rare insights into DNA repair pathways, TFIIH, aging and cancer center. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958537&form=6&db=m DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964549&form=6&db=m Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000400&form=6&db=m The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. causal interaction,diagnostic usage,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505093&form=6&db=m Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16563661&form=6&db=m The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy. therapeutic application,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16648558&form=6&db=m Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707462&form=6&db=m Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785234&form=6&db=m Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death. therapeutic application,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865228&form=6&db=m Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17203223&form=6&db=m cDNA analysis of gene expression associated with DNA-dependent protein kinase activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441731&form=6&db=m Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671421&form=6&db=m HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17724473&form=6&db=m P-TEFb inhibitors interfere with activation of p53 by DNA-damaging agents. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786349&form=6&db=m Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786356&form=6&db=m The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982634&form=6&db=m Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18026900&form=6&db=m Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity. ongoing research,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18249148&form=6&db=m A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. causal interaction,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18415044&form=6&db=m Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508926&form=6&db=m DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin. therapeutic application,unassigned 2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632984&form=6&db=m Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772145&form=6&db=m Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18785202&form=6&db=m 15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19114557&form=6&db=m An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19149561&form=6&db=m Topological polar surface area: a useful descriptor in 2D-QSAR. therapeutic application,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19305131&form=6&db=m Camptothecin releases P-TEFb from the inactive 7SK snRNP complex. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372586&form=6&db=m DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430698&form=6&db=m The role of autophagy in sensitizing malignant glioma cells to radiation therapy. causal interaction,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19579069&form=6&db=m Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672258&form=6&db=m Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19735256&form=6&db=m Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells. diagnostic usage,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794960&form=6&db=m A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808869&form=6&db=m Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19846528&form=6&db=m Abrogation of the Brd4-P-TEFb Positive Transcription Complex by the Papillomavirus E2 protein Contributes to the Viral Oncogene Repression. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20111054&form=6&db=m Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193758&form=6&db=m DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20380575&form=6&db=m Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20703082&form=6&db=m P-TEFb joins the family of cdks in oncology, promotes cell growth of cancer cells. ongoing research,unassigned 2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731906&form=6&db=m [The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.] causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20807885&form=6&db=m Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21079150&form=6&db=m Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360054&form=6&db=m New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC). unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385925&form=6&db=m Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target? causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21389092&form=6&db=m Deletion of the Proline-Rich Region of the Murine Metastasis Susceptibility Gene Brd4 Promotes Epithelial-to-Mesenchymal Transition- and Stem Cell-Like Conversion. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552262&form=6&db=m A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. therapeutic application,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21559021&form=6&db=m The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21630086&form=6&db=m Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21679440&form=6&db=m Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705845&form=6&db=m Gene Expression Associated with DNA-Dependent Protein Kinase Activity under Normoxia, Hypoxia, and Reoxygenation. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775006&form=6&db=m Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22009179&form=6&db=m Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22014955&form=6&db=m Radiosensitizing effects of ectopic miR-101 on non-small-cell lung cancer cells depend on the endogenous miR-101 level. ongoing research,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22131882&form=6&db=m DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22366497&form=6&db=m Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22377309&form=6&db=m [Misregulation of P-TEFb activity: pathological consequences]. causal interaction,unassigned 2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22576130&form=6&db=m Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22732390&form=6&db=m Simple synthesis of carbon-11-labeled chromen-4-one derivatives as new potential PET agents for imaging of DNA-dependent protein kinase (DNA-PK) in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22807979&form=6&db=m Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923485&form=6&db=m Threonine 2609 phosphorylation of the DNA-dependent Protein Kinase is a critical prerequisite for epidermal growth factor receptor mediated radiation resistance. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23107892&form=6&db=m Targeting DNA repair mechanisms in cancer. therapeutic application,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23227178&form=6&db=m Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23252711&form=6&db=m Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23362996&form=6&db=m DNA-dependent protein kinase and its inhibition in support of radiotherapy. therapeutic application,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23420345&form=6&db=m The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23505488&form=6&db=m Inactivation of DNA-Dependent Protein Kinase Promotes Heat-Induced Apoptosis Independently of Heat-Shock Protein Induction in Human Cancer Cell Lines. ongoing research,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536185&form=6&db=m Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23549790&form=6&db=m The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. ongoing research,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852730&form=6&db=m CTIP2 is a negative regulator of P-TEFb. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23989136&form=6&db=m Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24057508&form=6&db=m Chemo-sensitisation of HeLa cells to Etoposide by a Benzoxazine in the absence of DNA-PK inhibition. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24485452&form=6&db=m DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24508195&form=6&db=m A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum. ongoing research,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24576043&form=6&db=m The basal transcription machinery as a target for cancer therapy. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24586935&form=6&db=m Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24592384&form=6&db=m Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24627282&form=6&db=m Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24785829&form=6&db=m Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS. ongoing research,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24804542&form=6&db=m TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24953561&form=6&db=m Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25010594&form=6&db=m Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25138084&form=6&db=m The development of ataxia telangiectasia mutated kinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25168287&form=6&db=m Beyond DNA repair: DNA-PK function in cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25307307&form=6&db=m Developments of DNA-dependent Protein Kinase Inhibitors as Anticancer Agents. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25307308&form=6&db=m The development of ataxia telangiectasia mutated kinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25431422&form=6&db=m A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. therapeutic application,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25492483&form=6&db=m 7SK small nuclear RNA inhibits cancer cell proliferation through apoptosis induction. ongoing research,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25503124&form=6&db=m Inhibition of P-TEFb by DRB suppresses SIRT1/CK2? pathway and enhances radiosensitivity of human cancer cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25931285&form=6&db=m DNA damage in cancer therapeutics: a boon or a curse? causal interaction,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004008&form=6&db=m Targeting of the EGFR/?1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26074141&form=6&db=m Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083714&form=6&db=m Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26087309&form=6&db=m Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26171280&form=6&db=m AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26438155&form=6&db=m Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts. therapeutic application,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26603260&form=6&db=m Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. ongoing research,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26745862&form=6&db=m The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26762068&form=6&db=m [Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice]. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27135971&form=6&db=m Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair. causal interaction,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27187356&form=6&db=m Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27196891&form=6&db=m Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from (177)Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts. therapeutic application,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27341700&form=6&db=m Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27566146&form=6&db=m SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27572101&form=6&db=m Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27752877&form=6&db=m 7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27776457&form=6&db=m Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27887917&form=6&db=m MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994662&form=6&db=m TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28186989&form=6&db=m Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28399576&form=6&db=m Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423228&form=6&db=m Targeting DNA-Dependent Protein Kinase for Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28686579&form=6&db=m Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28775208&form=6&db=m A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies. therapeutic application,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28792271&form=6&db=m Is TFIIH the new Achilles heel of cancer cells? unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28820390&form=6&db=m Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28902838&form=6&db=m The cryo-electron microscopy structure of human transcription factor IIH. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088817&form=6&db=m CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113422&form=6&db=m Novel DNA targeted therapies for head and neck cancers: clinical potential and biomarkers. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150048&form=6&db=m DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29287602&form=6&db=m Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation. therapeutic application,unassigned 4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29371919&form=6&db=m Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29415883&form=6&db=m Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30057890&form=6&db=m Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30068551&form=6&db=m Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30230450&form=6&db=m [P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets]. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30337542&form=6&db=m DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30476230&form=6&db=m Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529192&form=6&db=m Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30603685&form=6&db=m Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy. therapeutic application,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798933&form=6&db=m TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30819820&form=6&db=m CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30842317&form=6&db=m Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30850485&form=6&db=m Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30857266&form=6&db=m Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair. therapeutic application,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30926564&form=6&db=m Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31266833&form=6&db=m Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31287365&form=6&db=m DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31380275&form=6&db=m DNA-PK as an Emerging Therapeutic Target in Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31395353&form=6&db=m DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516394&form=6&db=m Cell-type specific concentration regulation of the basal transcription factor TFIIH in XPBy/y mice model. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31522595&form=6&db=m The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. ongoing research,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31551253&form=6&db=m Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828418&form=6&db=m Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31853198&form=6&db=m First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31963603&form=6&db=m Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32075058&form=6&db=m P-TEFb as A Promising Therapeutic Target. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32133046&form=6&db=m DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172133&form=6&db=m Targeting DNA-PK in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32220971&form=6&db=m Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435614&form=6&db=m MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2T146 Phosphorylation. causal interaction,unassigned 3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32543350&form=6&db=m Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32610116&form=6&db=m DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32628111&form=6&db=m PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32690037&form=6&db=m CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38?/MYC/PD-L1 signaling in non-small cell lung cancer. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32839491&form=6&db=m A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours. causal interaction,unassigned 2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33007515&form=6&db=m Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33230210&form=6&db=m A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347360&form=6&db=m Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010-present). causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34011558&form=6&db=m Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108527&form=6&db=m DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144487&form=6&db=m Three targets in one complex: A molecular perspective of TFIIH in cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34193614&form=6&db=m Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34204447&form=6&db=m Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34212002&form=6&db=m Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases. ongoing research,unassigned 1,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249431&form=6&db=m NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation. unassigned - 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34372855&form=6&db=m Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.7.11.23 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34462666&form=6&db=m Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.23 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245929&form=6&db=m Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9183650&form=6&db=m Apoptotic human SH-SY5Y neuroblastoma cells have regularly spaced single strand DNA breaks and increased DNA-dependent protein kinase activity. ongoing research,unassigned 2,0 2.7.11.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10037464&form=6&db=m Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19142223&form=6&db=m Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner. ongoing research,unassigned 2,0 2.7.11.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26716839&form=6&db=m DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.7.11.23 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Neuroectodermal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12403924&form=6&db=m Upregulation of Ku expression in human neuroectodermal tumor cells after retroviral DNA integration. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.23 Neurofibromatoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30931649&form=6&db=m Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress. ongoing research,unassigned 3,0 2.7.11.23 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30931649&form=6&db=m Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress. ongoing research,unassigned 3,0 2.7.11.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33710283&form=6&db=m AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. unassigned - 2.7.11.23 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34212002&form=6&db=m Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases. ongoing research,unassigned 1,0 2.7.11.23 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150142&form=6&db=m Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition. diagnostic usage,unassigned 1,0 2.7.11.23 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952069&form=6&db=m Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17981541&form=6&db=m Role of IFI16 in DNA damage and checkpoint. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 non-specific serine/threonine protein kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489998&form=6&db=m SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28467930&form=6&db=m DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.23 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29077158&form=6&db=m Effects of caloric restriction on peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in obese rats. therapeutic application,unassigned 2,0 2.7.11.23 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26108997&form=6&db=m Targeting DNA-PKcs increased anticancer drug sensitivity by suppressing DNA damage repair in osteosarcoma cell line MG63. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.7.11.23 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28300555&form=6&db=m Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.23 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29203385&form=6&db=m The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12481432&form=6&db=m Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204287&form=6&db=m Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,3 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22131882&form=6&db=m DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22313686&form=6&db=m Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097887&form=6&db=m A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27655643&form=6&db=m Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27935869&form=6&db=m The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer. ongoing research,unassigned 1,0 2.7.11.23 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31827119&form=6&db=m Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.23 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25002126&form=6&db=m Elevated DNA damage response in pancreatic cancer. ongoing research,unassigned 1,0 2.7.11.23 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27621574&form=6&db=m Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.23 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28153717&form=6&db=m Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis. ongoing research,unassigned 3,0 2.7.11.23 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18637184&form=6&db=m Implications of tyrosine phosphoproteomics in cervical carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2 2.7.11.23 Parathyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17227113&form=6&db=m Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.23 Photophobia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509240&form=6&db=m Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31183407&form=6&db=m Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. ongoing research,unassigned 1,0 2.7.11.23 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31183407&form=6&db=m Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. ongoing research,unassigned 1,0 2.7.11.23 Polycythemia Vera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19004005&form=6&db=m Imbalance of DNA-dependent protein kinase subunits in polycythemia vera peripheral blood stem cells. ongoing research,unassigned 1,0 2.7.11.23 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33981307&form=6&db=m Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.7.11.23 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23989136&form=6&db=m Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.23 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24885447&form=6&db=m Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia. causal interaction,unassigned 1,0 2.7.11.23 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28821159&form=6&db=m Inhibition of DNA-PK enhances chemosensitivity of B-cell precursor acute lymphoblastic leukemia cells to doxorubicin. causal interaction,unassigned 4,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10734072&form=6&db=m From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266437&form=6&db=m Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571633&form=6&db=m Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12593864&form=6&db=m The second largest subunit of RNA polymerase II interacts with and enhances transactivation of androgen receptor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273218&form=6&db=m Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108124&form=6&db=m Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19556345&form=6&db=m Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation. causal interaction,unassigned 1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385925&form=6&db=m Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target? causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26438155&form=6&db=m Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts. therapeutic application,unassigned 3,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27068475&form=6&db=m Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer. causal interaction,unassigned 2,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27187356&form=6&db=m Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28062857&form=6&db=m Positive feedback loop mediated by protein phosphatase 1? mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer. diagnostic usage,unassigned 1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28399576&form=6&db=m Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28754673&form=6&db=m Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer Irradiation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31266829&form=6&db=m DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31266833&form=6&db=m Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32209447&form=6&db=m DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.23 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32610116&form=6&db=m DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21460372&form=6&db=m Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9204767&form=6&db=m Death substrates come alive. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.23 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15078984&form=6&db=m Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.23 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25852083&form=6&db=m DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. diagnostic usage,unassigned 1,0 2.7.11.23 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.7.11.23 Rhabdomyosarcoma, Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12218164&form=6&db=m Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region. unassigned - 2.7.11.23 Rift Valley Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14992716&form=6&db=m Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Rift Valley Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543505&form=6&db=m NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62. unassigned - 2.7.11.23 Rift Valley Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24403578&form=6&db=m Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. causal interaction,unassigned 1,0 2.7.11.23 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12210059&form=6&db=m Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.7.11.23 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29371919&form=6&db=m Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7479885&form=6&db=m Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. therapeutic application,unassigned 2,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8524788&form=6&db=m Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity. therapeutic application,unassigned 1,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647176&form=6&db=m Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts. unassigned - 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9632806&form=6&db=m DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9768755&form=6&db=m Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051409&form=6&db=m Elongated telomeres in scid mice. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10214916&form=6&db=m Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409328&form=6&db=m The neoplastic transformation of SCID cells by radiation. causal interaction,unassigned 2,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10570295&form=6&db=m Irradiation-induced rescue of thymocyte differentiation and V(D)J recombination in mice lacking the catalytic subunit of DNA-dependent protein kinase. unassigned - 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11003390&form=6&db=m Identification of four highly conserved regions in DNA-PKcs. unassigned - 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532879&form=6&db=m High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12565705&form=6&db=m Involvement of DNA-dependent protein kinase in down-regulation of cell cycle progression. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12971412&form=6&db=m Radiation-induced apoptosis in scid mice spleen after low dose irradiation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010310&form=6&db=m Dysfunctional mammalian telomeres join with DNA double-strand breaks. causal interaction,unassigned 1,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16874298&form=6&db=m DNA-PK autophosphorylation facilitates Artemis endonuclease activity. unassigned - 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21979916&form=6&db=m Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. ongoing research,unassigned 1,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251783&form=6&db=m DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. ongoing research,unassigned 2,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25441643&form=6&db=m DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.23 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26000857&form=6&db=m Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model. ongoing research,unassigned 4,0 2.7.11.23 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671271&form=6&db=m Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein. causal interaction,unassigned 3,0 2.7.11.23 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115885&form=6&db=m Analysis of U1 small nuclear RNA interaction with cyclin H. therapeutic application,unassigned 1,0 2.7.11.23 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18470933&form=6&db=m Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 (XPD) mutations: cancer-prone xeroderma pigmentosum vs. non-cancer-prone trichothiodystrophy. unassigned - 2.7.11.23 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817897&form=6&db=m Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients. unassigned - 2.7.11.23 Spinal Muscular Atrophies of Childhood http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8981949&form=6&db=m The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease. unassigned - 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14556663&form=6&db=m Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25735090&form=6&db=m [Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma]. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30057890&form=6&db=m Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490091&form=6&db=m Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828418&form=6&db=m Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32517381&form=6&db=m Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons. causal interaction,unassigned 2,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32611474&form=6&db=m The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33133138&form=6&db=m Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. therapeutic application,unassigned 4,0 2.7.11.23 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34204447&form=6&db=m Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.23 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861906&form=6&db=m A transcriptional autoregulatory loop for KIN28-CCL1 and SRB10-SRB11, each encoding RNA polymerase II CTD kinase-cyclin pair, stimulates the meiotic development of S. cerevisiae. unassigned - 2.7.11.23 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18662700&form=6&db=m The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.23 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31679687&form=6&db=m DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.11.23 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24764698&form=6&db=m Effects of dna-dependent protein kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric cancer cell line N87. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9115420&form=6&db=m Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family. therapeutic application,unassigned 1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10361259&form=6&db=m Molecular mechanisms of ionizing radiation-induced apoptosis. unassigned - 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556596&form=6&db=m Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571274&form=6&db=m ATM phosphorylates histone H2AX in response to DNA double-strand breaks. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660252&form=6&db=m Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15389585&form=6&db=m Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. unassigned - 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840517&form=6&db=m Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines. unassigned - 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17371003&form=6&db=m Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. therapeutic application,unassigned 4,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18162465&form=6&db=m ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. therapeutic application,unassigned 1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304914&form=6&db=m Transcription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22972376&form=6&db=m AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. therapeutic application,unassigned 1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23085754&form=6&db=m ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression. unassigned - 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23107892&form=6&db=m Targeting DNA repair mechanisms in cancer. therapeutic application,unassigned 3,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25138084&form=6&db=m The development of ataxia telangiectasia mutated kinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25307308&form=6&db=m The development of ataxia telangiectasia mutated kinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27572101&form=6&db=m Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells. unassigned - 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29144413&form=6&db=m Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle. causal interaction,unassigned 1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29162700&form=6&db=m Double-strand DNA breaks are mainly repaired by the homologous recombination pathway in early developing swine embryos. causal interaction,unassigned 1,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31838185&form=6&db=m The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by ?H2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells. ongoing research,unassigned 2,0 2.7.11.23 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34298632&form=6&db=m Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer? therapeutic application,unassigned 2,0 2.7.11.23 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30476230&form=6&db=m Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.7.11.23 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370278&form=6&db=m Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest. therapeutic application,unassigned 1,0 2.7.11.23 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20393018&form=6&db=m Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7613092&form=6&db=m TFIIH: a link between transcription, DNA repair and cell cycle regulation. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980491&form=6&db=m Transcription by RNA polymerase II: a process linked to DNA repair. therapeutic application,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9118947&form=6&db=m Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. causal interaction,unassigned 4,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9173976&form=6&db=m The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor. therapeutic application,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9631660&form=6&db=m Dual functions of DNA repair genes: molecular, cellular, and clinical implications. causal interaction,unassigned 3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9651581&form=6&db=m A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. causal interaction,unassigned 3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9771713&form=6&db=m Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH. diagnostic usage,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9885814&form=6&db=m Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10660593&form=6&db=m TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair. causal interaction,unassigned 2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062469&form=6&db=m Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11734544&form=6&db=m Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy. causal interaction,unassigned 4,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221129&form=6&db=m DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393803&form=6&db=m Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509240&form=6&db=m Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15220921&form=6&db=m A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A. causal interaction,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15590337&form=6&db=m Splitting hairs--discovery of a new DNA repair and transcription factor for the human disease trichothiodystrophy. causal interaction,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115885&form=6&db=m Analysis of U1 small nuclear RNA interaction with cyclin H. therapeutic application,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350038&form=6&db=m Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy. therapeutic application,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644494&form=6&db=m Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952069&form=6&db=m Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261133&form=6&db=m A new function of TFIIH explains the neurological symptoms in trichothiodystrophy. therapeutic application,unassigned 3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18510924&form=6&db=m XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. therapeutic application,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18579452&form=6&db=m Transcriptional changes in trichothiodystrophy cells. causal interaction,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18714286&form=6&db=m Structural basis for group A trichothiodystrophy. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19008953&form=6&db=m p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19172752&form=6&db=m Structural basis for group A trichothiodystrophy. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808800&form=6&db=m Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19897425&form=6&db=m Interacting partners of the Tfb2 subunit from yeast TFIIH. causal interaction,unassigned 3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429618&form=6&db=m Transcription factor IIH - the protein complex with multiple functions. therapeutic application,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21814739&form=6&db=m Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice. causal interaction,unassigned 3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22187342&form=6&db=m Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23221806&form=6&db=m XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression. causal interaction,unassigned 2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562818&form=6&db=m Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013903&form=6&db=m The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016283&form=6&db=m TTDA: Big impact of a small protein. causal interaction,unassigned 2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25154395&form=6&db=m Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin. causal interaction,unassigned 2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25340339&form=6&db=m Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25605938&form=6&db=m TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25620205&form=6&db=m TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26996949&form=6&db=m GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy. causal interaction,unassigned 2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27805905&form=6&db=m Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation. causal interaction,unassigned 2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28902838&form=6&db=m The cryo-electron microscopy structure of human transcription factor IIH. causal interaction,unassigned 3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30068551&form=6&db=m Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798933&form=6&db=m TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair. unassigned - 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31064989&form=6&db=m TFIIE orchestrates the recruitment of the TFIIH kinase module at promoter before release during transcription. causal interaction,unassigned 3,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31110295&form=6&db=m Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. therapeutic application,unassigned 1,0 2.7.11.23 Trichothiodystrophy Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31963603&form=6&db=m Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases. causal interaction,unassigned 3,0 2.7.11.23 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32520633&form=6&db=m HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.23 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745306&form=6&db=m Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma. therapeutic application,unassigned 2,0 2.7.11.23 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15551138&form=6&db=m Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.23 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000400&form=6&db=m The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. causal interaction,diagnostic usage,unassigned 3,4,0 2.7.11.23 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292648&form=6&db=m T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex. therapeutic application,unassigned 2,0 2.7.11.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21829721&form=6&db=m Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2. unassigned - 2.7.11.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098118&form=6&db=m A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus. causal interaction,unassigned 1,0 2.7.11.23 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30428360&form=6&db=m DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888655&form=6&db=m The matrix protein of vesicular stomatitis virus inhibits host-directed transcription of target genes via interaction with the TFIIH subunit p8. therapeutic application,unassigned 1,0 2.7.11.23 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33349862&form=6&db=m A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315). diagnostic usage,unassigned 3,0 2.7.11.23 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34398236&form=6&db=m A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy. diagnostic usage,unassigned 1,0 2.7.11.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960356&form=6&db=m The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867762&form=6&db=m Interferon regulatory factor-3 is an in vivo target of DNA-PK. therapeutic application,unassigned 1,0 2.7.11.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15279776&form=6&db=m Role of DNA-PK in the cellular response to DNA double-strand breaks. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22377309&form=6&db=m [Misregulation of P-TEFb activity: pathological consequences]. causal interaction,unassigned 2,0 2.7.11.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22999307&form=6&db=m Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25416801&form=6&db=m HIV-1 transcription is regulated by splicing factor SRSF1. causal interaction,unassigned 1,0 2.7.11.23 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144993&form=6&db=m Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.23 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10989122&form=6&db=m Repair of telomeric DNA prior to replicative senescence. unassigned - 2.7.11.23 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477099&form=6&db=m Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. unassigned - 2.7.11.23 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372586&form=6&db=m DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.23 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24429382&form=6&db=m Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks. causal interaction,unassigned 3,0 2.7.11.23 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20097157&form=6&db=m IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7613092&form=6&db=m TFIIH: a link between transcription, DNA repair and cell cycle regulation. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980491&form=6&db=m Transcription by RNA polymerase II: a process linked to DNA repair. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8652557&form=6&db=m Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663148&form=6&db=m A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8687116&form=6&db=m Xeroderma pigmentosum and molecular cloning of DNA repair genes. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8811174&form=6&db=m DNA excision repair. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9118947&form=6&db=m Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. causal interaction,unassigned 4,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9173976&form=6&db=m The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9422774&form=6&db=m Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein. ongoing research,unassigned 2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9557707&form=6&db=m Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9631660&form=6&db=m Dual functions of DNA repair genes: molecular, cellular, and clinical implications. causal interaction,unassigned 3,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9771713&form=6&db=m Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH. diagnostic usage,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9774388&form=6&db=m RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62. diagnostic usage,therapeutic application,unassigned 1,2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9885814&form=6&db=m Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10064601&form=6&db=m Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH. causal interaction,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10467415&form=6&db=m Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556596&form=6&db=m Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10644710&form=6&db=m Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10660593&form=6&db=m TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair. causal interaction,unassigned 2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11027286&form=6&db=m Mechanism of promoter melting by the xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11239393&form=6&db=m Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. causal interaction,unassigned 3,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11242112&form=6&db=m A temperature-sensitive disorder in basal transcription and DNA repair in humans. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292853&form=6&db=m Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331764&form=6&db=m TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11709541&form=6&db=m Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11734544&form=6&db=m Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy. causal interaction,unassigned 4,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11955452&form=6&db=m XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221129&form=6&db=m DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393803&form=6&db=m Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509240&form=6&db=m Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358100&form=6&db=m Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494306&form=6&db=m Selective regulation of vitamin D receptor-responsive genes by TFIIH. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15549133&form=6&db=m Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15982307&form=6&db=m Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features. causal interaction,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16600867&form=6&db=m Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16947863&form=6&db=m Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403617&form=6&db=m Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466626&form=6&db=m Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18177054&form=6&db=m The carboxy-terminal domain of xeroderma pigmentosum complementation group C protein, involved in TFIIH and centrin binding, is highly disordered. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18510924&form=6&db=m XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19008953&form=6&db=m p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934020&form=6&db=m Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients. causal interaction,unassigned 2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429618&form=6&db=m Transcription factor IIH - the protein complex with multiple functions. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20482310&form=6&db=m The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20797633&form=6&db=m MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876134&form=6&db=m Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22187342&form=6&db=m Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23083890&form=6&db=m Lack of CAK complex accumulation at DNA damage sites in XP-B and XP-B/CS fibroblasts reveals differential regulation of CAK anchoring to core TFIIH by XPB and XPD helicases during nucleotide excision repair. causal interaction,unassigned 3,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23352696&form=6&db=m DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013903&form=6&db=m The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016283&form=6&db=m TTDA: Big impact of a small protein. causal interaction,unassigned 2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25605938&form=6&db=m TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25620205&form=6&db=m TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26996949&form=6&db=m GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy. causal interaction,unassigned 2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27805905&form=6&db=m Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation. causal interaction,unassigned 2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28902838&form=6&db=m The cryo-electron microscopy structure of human transcription factor IIH. causal interaction,unassigned 3,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29036418&form=6&db=m Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-?B and AP-1 signalling. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29959982&form=6&db=m Analysis of the conserved NER helicases (XPB and XPD) and UV-induced DNA damage in Hydra. causal interaction,unassigned 2,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798933&form=6&db=m TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair. unassigned - 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30894545&form=6&db=m Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31110295&form=6&db=m Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. therapeutic application,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31963603&form=6&db=m Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases. causal interaction,unassigned 3,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32434920&form=6&db=m Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters. ongoing research,unassigned 1,0 2.7.11.23 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381997&form=6&db=m Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8650264&form=6&db=m DNA-dependent protein kinase defects are linked to deficiencies in DNA repair and V(D)J recombination. unassigned - 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9375373&form=6&db=m DNA-dependent protein kinase. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728683&form=6&db=m DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. ongoing research,unassigned 3,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11432981&form=6&db=m Role of DNA-dependent protein kinase in neuronal survival. causal interaction,unassigned 4,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12218126&form=6&db=m Variable diversity joining recombination: nonhairpin coding ends in thymocytes of SCID and wild-type mice. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14612396&form=6&db=m Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells. causal interaction,unassigned 2,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010310&form=6&db=m Dysfunctional mammalian telomeres join with DNA double-strand breaks. causal interaction,unassigned 1,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193758&form=6&db=m DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27376156&form=6&db=m DNA-PK Deficiency in Alzheimer's Disease. causal interaction,unassigned 4,0 2.7.11.23 [rna-polymerase]-subunit kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273464&form=6&db=m DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity. causal interaction,unassigned 4,0