2.7.11.16 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30984536&form=6&db=m Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBP?, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.16 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955119&form=6&db=m Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice. causal interaction,unassigned 4,0 2.7.11.16 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19478075&form=6&db=m GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.16 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21041302&form=6&db=m GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity. unassigned - 2.7.11.16 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24598771&form=6&db=m GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity. causal interaction,unassigned 4,0 2.7.11.16 Aortic Coarctation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28106155&form=6&db=m Secreted miR-27a Induced by Cyclic Stretch Modulates the Proliferation of Endothelial Cells in Hypertension via GRK6. causal interaction,unassigned 2,0 2.7.11.16 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34006987&form=6&db=m G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis. unassigned - 2.7.11.16 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25049040&form=6&db=m G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving ?-blockers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.7.11.16 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18767025&form=6&db=m Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.16 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18767025&form=6&db=m Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.16 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23375037&form=6&db=m GRK6 expression in patients with hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.16 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28819396&form=6&db=m Expression and Significances of G-Protein-Coupled Receptor Kinase 3 in Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 2.7.11.16 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22859683&form=6&db=m Determining the Absolute Requirement of G Protein-Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy. unassigned - 2.7.11.16 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23023506&form=6&db=m G protein-coupled receptor kinase 5: exploring its hype in cardiac hypertrophy. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.16 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26515328&form=6&db=m Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. causal interaction,unassigned 3,0 2.7.11.16 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29628444&form=6&db=m PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.16 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32856617&form=6&db=m KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.16 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33560342&form=6&db=m GRK5 contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure. ongoing research,unassigned 1,0 2.7.11.16 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21036254&form=6&db=m Characterization of G protein-coupled receptor kinase 4 and measuring its constitutive activity in vivo. causal interaction,unassigned 4,0 2.7.11.16 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24210504&form=6&db=m Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.16 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17229795&form=6&db=m G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.16 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575264&form=6&db=m G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells. ongoing research,unassigned 4,0 2.7.11.16 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22126303&form=6&db=m Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth. ongoing research,unassigned 4,0 2.7.11.16 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552218&form=6&db=m Overexpression of GRK6 associates with the progression and prognosis of colorectal carcinoma. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.16 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26614013&form=6&db=m Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.16 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24594703&form=6&db=m GRK5 Intronic (CA)n Polymorphisms Associated with Type 2 Diabetes in Chinese Hainan Island. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.16 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663513&form=6&db=m A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.16 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24594703&form=6&db=m GRK5 Intronic (CA)n Polymorphisms Associated with Type 2 Diabetes in Chinese Hainan Island. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.16 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663513&form=6&db=m A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.16 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22979934&form=6&db=m [Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease]. ongoing research,unassigned 2,0 2.7.11.16 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24376341&form=6&db=m Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and ?-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson's disease. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.16 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11904438&form=6&db=m G protein-coupled receptor kinase 4 gene variants in human essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.16 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15097232&form=6&db=m Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0 2.7.11.16 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16776954&form=6&db=m [G protein kinase 4gammaA142V overexpression induced hypertension by downregulating D1 receptors in transgenic mice] ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.16 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044852&form=6&db=m Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese. ongoing research,unassigned 2,0 2.7.11.16 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19520868&form=6&db=m G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. causal interaction,unassigned 3,0 2.7.11.16 g-protein-coupled receptor kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23589623&form=6&db=m G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.16 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28903336&form=6&db=m G protein-coupled receptor kinase 6 is overexpressed in glioma and promotes glioma cell proliferation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.16 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11027943&form=6&db=m beta-adrenergic mechanisms in cardiac diseases: a perspective. unassigned - 2.7.11.16 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15914116&form=6&db=m G-protein-coupled receptor kinase activity in human heart failure: effects of beta-adrenoceptor blockade. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.16 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20443857&form=6&db=m Pharmacogenomics of beta-Adrenergic Receptors and Their Accessory Signaling Proteins in Heart Failure. causal interaction,unassigned 3,0 2.7.11.16 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106943&form=6&db=m The inotropic peptide ?ARKct improves ?AR responsiveness in normal and failing cardiomyocytes through G(??)-mediated L-type calcium current disinhibition. therapeutic application,unassigned 1,0 2.7.11.16 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24174526&form=6&db=m Regulation of nuclear factor ?B (NF-?B) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5). causal interaction,unassigned 4,0 2.7.11.16 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27618959&form=6&db=m The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.16 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32856617&form=6&db=m KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.16 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33785612&form=6&db=m A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. therapeutic application,unassigned 1,0 2.7.11.16 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18687398&form=6&db=m G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia. unassigned - 2.7.11.16 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22331028&form=6&db=m GRK6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting PI3kinase- and inhibiting p38-signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151780&form=6&db=m G-protein-coupled receptor kinase activity is increased in hypertension. causal interaction,unassigned 4,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9405459&form=6&db=m G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340920&form=6&db=m G-protein-coupled receptor kinase expression in hypertension. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10642272&form=6&db=m G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. unassigned - 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809362&form=6&db=m Autosomal genome scan for loci linked to blood pressure levels and trends since childhood: the Bogalusa Heart Study. therapeutic application,unassigned 1,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190783&form=6&db=m G protein-coupled receptor kinase 4gamma interacts with inactive Galpha(s) and Galpha13. causal interaction,unassigned 4,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957817&form=6&db=m Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060223&form=6&db=m The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension. unassigned - 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20153824&form=6&db=m Dopamine and G protein-coupled receptor kinase 4 in the kidney: Role in blood pressure regulation. ongoing research,unassigned 3,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20448640&form=6&db=m G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese. causal interaction,unassigned 3,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544086&form=6&db=m G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22518293&form=6&db=m Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24942010&form=6&db=m Changes in Adrenoceptors and G-Protein-Coupled Receptor Kinase 2 in L-NAME-Induced Hypertension Compared to Spontaneous Hypertension in Rats. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25775155&form=6&db=m The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25870190&form=6&db=m G protein-coupled receptor kinase 4: role in hypertension. unassigned - 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26134571&form=6&db=m Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4. unassigned - 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32349533&form=6&db=m Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension. causal interaction,unassigned 1,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33280021&form=6&db=m The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.16 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33899625&form=6&db=m Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients. causal interaction,unassigned 4,0 2.7.11.16 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136390&form=6&db=m GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.16 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28024497&form=6&db=m [Effect of G Protein-coupled Receptor Kinase 6 on Proliferation and Apoptosis of Multiple Myeloma Cells and Its Mechanisms]. unassigned - 2.7.11.16 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402162&form=6&db=m Down-regulated G protein-coupled receptor kinase 6 leads to apoptosis in multiple myeloma MM1R cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.16 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33971243&form=6&db=m Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.16 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34291633&form=6&db=m Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma. therapeutic application,unassigned 4,0 2.7.11.16 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33280021&form=6&db=m The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.16 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23589623&form=6&db=m G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.16 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24434559&form=6&db=m GRK3 is essential for metastatic cells and promotes prostate tumor progression. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.16 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24755472&form=6&db=m G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22099983&form=6&db=m G-protein coupled receptor kinase 5 regulates prostate tumor growth. ongoing research,unassigned 2,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23589623&form=6&db=m G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24434559&form=6&db=m GRK3 is essential for metastatic cells and promotes prostate tumor progression. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26462147&form=6&db=m GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis. causal interaction,unassigned 3,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232975&form=6&db=m c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254792&form=6&db=m High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma. causal interaction,unassigned 4,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29463786&form=6&db=m GRK5 functions as an oncogenic factor in non-small-cell lung cancer. therapeutic application,unassigned 1,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31363957&form=6&db=m G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel. therapeutic application,unassigned 2,0 2.7.11.16 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31832002&form=6&db=m MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.16 Nephrosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19119263&form=6&db=m G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.16 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11856737&form=6&db=m Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.16 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29773828&form=6&db=m Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans. therapeutic application,unassigned 3,0 2.7.11.16 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31696655&form=6&db=m GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-?B Signaling. causal interaction,unassigned 3,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16957079&form=6&db=m The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. causal interaction,unassigned 4,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19852948&form=6&db=m G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression. causal interaction,unassigned 3,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21046632&form=6&db=m Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease. causal interaction,unassigned 2,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21184589&form=6&db=m Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease. causal interaction,unassigned 2,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22979934&form=6&db=m [Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease]. ongoing research,unassigned 2,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24376341&form=6&db=m Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and ?-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson's disease. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26614013&form=6&db=m Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32343709&form=6&db=m S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.16 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32555609&form=6&db=m Correction: S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.16 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20448640&form=6&db=m G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese. causal interaction,unassigned 3,0 2.7.11.16 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24755472&form=6&db=m G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.16 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22410551&form=6&db=m Beta-adrenoreceptor (?-AR) agonism influences retinal responses to hypoxia in a mouse model of retinopathy of prematurity. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.16 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11166332&form=6&db=m G-protein-coupled receptor kinase 3- and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells. ongoing research,unassigned 3,0 2.7.11.16 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359120&form=6&db=m Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat. causal interaction,unassigned 2,0 2.7.11.16 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29080472&form=6&db=m The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.16 Stillbirth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26886170&form=6&db=m Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization. ongoing research,unassigned 3,0 2.7.11.16 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31832002&form=6&db=m MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.16 Takotsubo Cardiomyopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23794609&form=6&db=m No association of G-protein-coupled receptor kinase 5 or ?-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. causal interaction,unassigned 2,0 2.7.11.16 Takotsubo Cardiomyopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25010510&form=6&db=m G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy. causal interaction,unassigned 3,0 2.7.11.16 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805156&form=6&db=m Overexpression of G Protein-Coupled Receptor Kinase 6 (GRK6) Is Associated with Progression and Poor Prognosis of Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.16 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14523027&form=6&db=m Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. unassigned -