2.7.11.13 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7861936&form=6&db=m Effect of dietary fat on colonic protein kinase C and induction of aberrant crypt foci. ongoing research,unassigned 2,0 2.7.11.13 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9394711&form=6&db=m Fatty acids and colon cancer in experimental models. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10330400&form=6&db=m Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245437&form=6&db=m Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.7.11.13 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322124&form=6&db=m Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Abnormalities, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635246&form=6&db=m Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype. causal interaction,unassigned 3,0 2.7.11.13 Acantholysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377341&form=6&db=m In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Acantholysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18073210&form=6&db=m Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7736502&form=6&db=m Modulation of sodium-hydrogen exchange activity in cardiac myocytes during acidosis and realkalinisation: effects on calcium, pHi, and cell shortening. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8661219&form=6&db=m Alpha-adrenergic preservation of myocardial pH during ischemia is PKC isoform dependent. causal interaction,unassigned 4,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9191501&form=6&db=m The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications. causal interaction,unassigned 3,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202667&form=6&db=m Protein kinase C isoform diversity in preconditioning. therapeutic application,unassigned 1,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9416329&form=6&db=m Role of protein kinase C in acidosis induced glial swelling--current understanding. causal interaction,unassigned 2,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9747432&form=6&db=m The cardiac adrenergic system in ischaemia: differential role of acidosis and energy depletion. causal interaction,unassigned 4,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10329217&form=6&db=m Repetitive acidosis protects the ischemic heart: implications for mechanisms in preconditioned hearts. causal interaction,unassigned 4,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10592293&form=6&db=m Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10679491&form=6&db=m Possible mechanism(s) of arachidonic acid-induced intracellular acidosis in rat cardiac myocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11463575&form=6&db=m Regulation of apoA1 gene expression with acidosis: requirement for a transcriptional repressor. therapeutic application,unassigned 1,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11700015&form=6&db=m Acidosis inhibits gallbladder contraction mediated by protein kinase C activation. therapeutic application,unassigned 1,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11743883&form=6&db=m Advantages of pyruvate over lactate in peritoneal dialysis solutions. causal interaction,unassigned 4,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12508083&form=6&db=m Deficient brain RNA polymerase and altered nucleolar structure persists until day 8 after perinatal asphyxia of the rat. causal interaction,unassigned 3,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14606521&form=6&db=m Regulatory mechanisms and physiological relevance of a voltage-gated H+ channel in murine osteoclasts: phorbol myristate acetate induces cell acidosis and the channel activation. therapeutic application,unassigned 1,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14672811&form=6&db=m Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15973767&form=6&db=m Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140162&form=6&db=m An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16582576&form=6&db=m Mice Lacking Protein Kinase C Beta Present Modest Increases in Systolic Blood Pressure and NH(4)Cl-Induced Metabolic Acidosis. ongoing research,unassigned 3,0 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389262&form=6&db=m The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis. unassigned - 2.7.11.13 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27022190&form=6&db=m Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. unassigned - 2.7.11.13 Acidosis, Respiratory http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8286716&form=6&db=m Role of protein kinase C in the adaptive increase in Na-H antiporter in respiratory acidosis. causal interaction,unassigned 3,0 2.7.11.13 Acidosis, Respiratory http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9543492&form=6&db=m Regulation of renal Na-HCO3 cotransporter: VIII. Mechanism Of stimulatory effect of respiratory acidosis. ongoing research,unassigned 3,0 2.7.11.13 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8204465&form=6&db=m Anti-inflammatory actions of benzoyl peroxide: effects on the generation of reactive oxygen species by leucocytes and the activity of protein kinase C and calmodulin. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2493338&form=6&db=m Stimulation of AIDS lymphocytes with calcium ionophore (A23187) and phorbol ester (PMA): studies of cytoplasmic free Ca, IL-2 receptor expression, IL-2 production, and proliferation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353882&form=6&db=m Effect of human immunodeficiency virus type 1 on intracellular activation and superoxide production by neutrophils. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.7.11.13 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449873&form=6&db=m A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21064191&form=6&db=m Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C? causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22539107&form=6&db=m Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C?. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677503&form=6&db=m Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin. unassigned - 2.7.11.13 Acromegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2060147&form=6&db=m Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture. causal interaction,unassigned 3,0 2.7.11.13 Acromegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8596491&form=6&db=m Growth hormone secretion in human acromegalic pituitary adenomas: cyclic adenosine monophosphate and protein kinase C responses. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Acromegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10507079&form=6&db=m Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.7.11.13 ACTH-Secreting Pituitary Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522132&form=6&db=m Protein Kinase C Delta restrains growth in ACTH-secreting pituitary adenoma cells. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Acute Generalized Exanthematous Pustulosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928424&form=6&db=m Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways. therapeutic application,unassigned 2,0 2.7.11.13 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33378064&form=6&db=m Expression of syndecan-1, PKC and VEGF in rats with acute kidney injury and correlation between syndecan-1 and renal function. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307672&form=6&db=m PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury. causal interaction,unassigned 4,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8026208&form=6&db=m The protein kinase C inhibitor, H-7, induces acute lung injury in guinea pigs. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573983&form=6&db=m Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16214426&form=6&db=m Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204411&form=6&db=m Protein kinase C inhibition attenuates hypochlorite-induced acute lung injury. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27486964&form=6&db=m Protein Kinase C Zeta Inhibitor Promotes Resolution of Bleomycin-induced Acute Lung Injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29471107&form=6&db=m PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT. causal interaction,unassigned 4,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402043&form=6&db=m PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31297750&form=6&db=m Protein Kinase C Theta Inhibition Attenuates Lipopolysaccharide-Induced Acute Lung Injury through Notch Signaling Pathway via Suppressing Th17 Cell Response in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949727&form=6&db=m Transient cerebral ischemia/reperfusion-induced acute lung injury in rats associated with protein kinase C alpha expression. unassigned - 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1371717&form=6&db=m Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1421693&form=6&db=m [Regulation by protein kinase C of TGF-beta 1 expression in cultured cells of breast adenocarcinoma] causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1467312&form=6&db=m Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559225&form=6&db=m Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696850&form=6&db=m Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2009306&form=6&db=m Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2018349&form=6&db=m Effects of dietary fish oil and corn oil on protein kinase C distribution in the rat colon with and without 1,2 dimethylhydrazine treatment and in rat colonic adenocarcinoma. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161375&form=6&db=m Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496916&form=6&db=m Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells. ongoing research,unassigned 1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2708332&form=6&db=m Regulation of Na+/K+/Cl- cotransport and [3H]bumetanide binding site density by phorbol esters in HT29 cells. ongoing research,unassigned 4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999261&form=6&db=m Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8131683&form=6&db=m Loss of protein kinase C delta isozyme immunoreactivity in human adenocarcinomas. ongoing research,unassigned 3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8325890&form=6&db=m The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein. ongoing research,unassigned 2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408180&form=6&db=m Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809413&form=6&db=m Localization of protein kinase C alpha isoform expression in the human gastrointestinal tract. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8878412&form=6&db=m Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression. ongoing research,unassigned 3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150275&form=6&db=m Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D- and protein kinase C-dependent pathways in murine mammary adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9180160&form=6&db=m A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and beta1-integrin point contact distribution. diagnostic usage,therapeutic application,unassigned 3,2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9294011&form=6&db=m Transcriptional regulation of surfactant proteins SP-A and SP-B by phorbol ester. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9345355&form=6&db=m Epidermal growth factor activates protein kinase C in the human endometrial cancer cell line HEC-1-A. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9396040&form=6&db=m Tamoxifen alters the localization of F-actin and alpha 5/beta 1-integrin fibronectin receptors in human endometrial stromal cells and carcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9442087&form=6&db=m Photoinduced inactivation of protein kinase C by dequalinium identifies the RACK-1-binding domain as a recognition site. unassigned - 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9500474&form=6&db=m Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9649461&form=6&db=m Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9769475&form=6&db=m Cytoskeletal reorganization induced by retinoic acid treatment of human endometrial adenocarcinoma (RL95-2) cells is correlated with alterations in protein kinase C-alpha. unassigned - 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9916928&form=6&db=m Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10094832&form=6&db=m Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545022&form=6&db=m TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment. therapeutic application,unassigned 3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11464292&form=6&db=m CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11709203&form=6&db=m Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616719&form=6&db=m Manipulating expression of endogenous oncogenic proteins using an antisense oligonucleotide approach in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920244&form=6&db=m Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500753&form=6&db=m Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654790&form=6&db=m PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161701&form=6&db=m Pak-1 expression increases with progression of colorectal carcinomas to metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555220&form=6&db=m Expression levels of protein kinase C-alpha in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15647851&form=6&db=m Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15744586&form=6&db=m Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15837731&form=6&db=m Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003101&form=6&db=m Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608772&form=6&db=m Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia. ongoing research,unassigned 1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875724&form=6&db=m Protein Kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19523467&form=6&db=m PKCeta confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672862&form=6&db=m Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21406403&form=6&db=m Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544325&form=6&db=m Dexniguldipine hydrochloride inhibits growth of human pancreatic adenocarcinoma cells and expression of protein kinase C isoforms alpha and zeta. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28085924&form=6&db=m Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29158810&form=6&db=m Phosphorylated Protein Kinase C (Zeta/Lambda) Expression in Colorectal Adenocarcinoma and Its Correlation with Clinicopathologic Characteristics and Prognosis. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708689&form=6&db=m Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32762399&form=6&db=m A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. causal interaction,unassigned 1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33146712&form=6&db=m Transcription factor Sp1 is upregulated by PKC? to drive the expression of YAP1 during pancreatic carcinogenesis. causal interaction,unassigned 1,0 2.7.11.13 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34375670&form=6&db=m PKC? regulates the expression of PDL1 through multiple pathways to modulate immune suppression of pancreatic cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329908&form=6&db=m Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1569201&form=6&db=m Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II). therapeutic application,unassigned 2,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8939353&form=6&db=m P2u purinoceptor modulation of intracellular Ca2+ in a human lung adenocarcinoma cell line: down-regulation of Ca2+ influx by protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525155&form=6&db=m Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. ongoing research,unassigned 2,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055435&form=6&db=m Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204062&form=6&db=m Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19223491&form=6&db=m Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19459855&form=6&db=m Protein kinase Calpha-responsive polymeric carrier: its application for gene delivery into human cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19500428&form=6&db=m Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24318287&form=6&db=m Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression. causal interaction,unassigned 3,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28983601&form=6&db=m PKC?, MMP?2 and MMP?9 expression in lung adenocarcinoma and association with a metastatic phenotype. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31412817&form=6&db=m Clinical significance of atypical protein kinase C (PKC? and PKC?) and its relationship with yes-associated protein in lung adenocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32945503&form=6&db=m Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF??. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32994205&form=6&db=m PKC epsilon is required for KRAS-driven lung tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.7.11.13 Adenocarcinoma, Follicular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12951842&form=6&db=m Standard and molecular cytogenetics of endocrine tumors. causal interaction,unassigned 1,0 2.7.11.13 Adenocarcinoma, Follicular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18480379&form=6&db=m Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1347514&form=6&db=m Protein kinase C activity and expression in normal and adenomatous human pituitaries. ongoing research,unassigned 2,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1451074&form=6&db=m Protein kinase C activity in human thyroid carcinoma and adenoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1586595&form=6&db=m Correlation between protein kinase C activity and histopathological criteria in human colorectal adenoma. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1727670&form=6&db=m Protein kinase C activity in human colonic adenoma and colorectal carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1807790&form=6&db=m Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1988085&form=6&db=m Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569396&form=6&db=m Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3342264&form=6&db=m Modulation of the Ca2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651730&form=6&db=m The natural protein kinase C alpha mutant is present in human thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7951545&form=6&db=m ACTH and phorbol ester stimulated redistribution of protein kinase C in human cortisol-producing adrenal adenoma. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999261&form=6&db=m Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8434650&form=6&db=m Protein kinase C (PKC) activity and PKC messenger RNAs in human pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698190&form=6&db=m Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,1 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769390&form=6&db=m Nonfunctioning adenomas of the pituitary. causal interaction,unassigned 4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964400&form=6&db=m Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167945&form=6&db=m Protein kinase C alpha and tumorigenesis of the endocrine gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9466321&form=6&db=m ACTH-induced cortisol secretion is mediated by cAMP and PKC in various adrenocortical adenomas. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9487993&form=6&db=m Adrenomedullin gene expression and its different regulation in human adrenocortical and medullary tumors. therapeutic application,unassigned 1,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9935229&form=6&db=m Anti-proliferative activity of protein kinase C in apical compartments of human colonic crypts: evidence for a less activated protein kinase C in small adenomas. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10507079&form=6&db=m Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728913&form=6&db=m Molecular basis of pituitary oncogenesis. causal interaction,unassigned 2,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11713587&form=6&db=m Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994357&form=6&db=m Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173071&form=6&db=m Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161701&form=6&db=m Pak-1 expression increases with progression of colorectal carcinomas to metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16197574&form=6&db=m Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940160&form=6&db=m Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317448&form=6&db=m Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19434801&form=6&db=m Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31708689&form=6&db=m Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32357622&form=6&db=m Hybridization studies of cultured human pituitary prl and gh producing adenoma cells: Effects of thyrotropin-releasing hormone, somatostatin, and phorbol ester. diagnostic usage,unassigned 3,0 2.7.11.13 Adenoma, Liver Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376789&form=6&db=m Alteration of protein kinase C isoform-specific expression during rat hepatocarcinogenesis after exposure to the peroxisome proliferator WY-14,643. diagnostic usage,unassigned 3,0 2.7.11.13 Adenoma, Oxyphilic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116406&form=6&db=m MicroRNAs as Urinary Biomarker for Oncocytoma. causal interaction,unassigned 1,0 2.7.11.13 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10330400&form=6&db=m Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27792527&form=6&db=m Induction of the SHARP-2 mRNA level by insulin is mediated by multiple signaling pathways. unassigned - 2.7.11.13 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2892695&form=6&db=m Negative regulation of atrial natriuretic factor receptor coupled membrane guanylate cyclase by phorbol ester. Potential protein kinase C regulation of cyclic GMP signal in isolated adrenocortical carcinoma cells of rat. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663337&form=6&db=m Expression and regulation of the lipoprotein lipase gene in human adrenal cortex. causal interaction,unassigned 1,0 2.7.11.13 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943800&form=6&db=m Regulation of 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964847&form=6&db=m Differential control of 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells. ongoing research,unassigned 4,0 2.7.11.13 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12943994&form=6&db=m AngII induces transient phospholipase D activity in the H295R glomerulosa cell model. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Adrenocortical Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23900415&form=6&db=m Protein kinase C-induced activin A switches adrenocortical steroidogenesis to aldosterone by suppressing CYP17A1 expression. therapeutic application,unassigned 2,0 2.7.11.13 Adrenoleukodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639664&form=6&db=m Phospholipase D activity is altered in X-linked adrenoleukodystrophy heterozygous carriers, but not in hemizygous patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Adrenoleukodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10896308&form=6&db=m Perturbation of protein kinase C subtype activation in X-ALD fibroblasts: possible involvement of protein kinase C in the pathogenesis of adrenoleukodystrophy. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Aggressive Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316876&form=6&db=m Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Aggressive Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8158498&form=6&db=m Chemoluminescence generation and MTT dye reduction by polymorphonuclear leukocytes from periodontal disease patients. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Aggressive Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872962&form=6&db=m Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis. causal interaction,unassigned 1,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653156&form=6&db=m Effect of protein kinase C modulators on the leucocyte Na+/H+ antiport in type 1 (insulin-dependent) diabetic subjects with albuminuria. unassigned - 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165458&form=6&db=m Effect of protein kinase C modulators on the leucocyte Na+/H+ antiport in type 1 (insulin-dependent) diabetic subjects with albuminuria. causal interaction,unassigned 3,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9071711&form=6&db=m Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. therapeutic application,unassigned 1,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10615954&form=6&db=m Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654761&form=6&db=m Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2. ongoing research,unassigned 3,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277392&form=6&db=m Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16955103&form=6&db=m Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699475&form=6&db=m Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566543&form=6&db=m Bioactive peptides control receptor for advanced glycated end product-induced elevation of kidney insulin receptor substrate 2 and reduce albuminuria in diabetic mice. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20395372&form=6&db=m PKC-{delta} Promotes Renal Tubular Cell Apoptosis Associated with Proteinuria. causal interaction,unassigned 4,0 2.7.11.13 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521876&form=6&db=m Renoprotective effect of a novel selective PPAR? modulator K-877 in db/db mice: A role of diacylglycerol-protein kinase C-NAD(P)H oxidase pathway. unassigned - 2.7.11.13 Alcoholic Neuropathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069970&form=6&db=m Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.7.11.13 Alkalosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7835278&form=6&db=m Impaired protein kinase C activation is associated with decreased hepatic alpha 1-adrenoreceptor responsiveness in adrenalectomized rats. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Alkalosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9612280&form=6&db=m PKC activation is required by EGF-stimulated Na(+)-H+ exchanger in human pleural mesothelial cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810623&form=6&db=m Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1792001&form=6&db=m Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1880547&form=6&db=m Protein kinase C alteration is an early biochemical marker in Alzheimer's disease. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1990207&form=6&db=m Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains. ongoing research,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2002333&form=6&db=m Autoradiographic imaging of [3H]phorbol 12,13-dibutyrate binding to protein kinase C in Alzheimer's disease. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2198779&form=6&db=m Aberrant protein kinase C cascades in Alzheimer's disease. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2376771&form=6&db=m Differential involvement of protein kinase C isozymes in Alzheimer's disease. causal interaction,unassigned 2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2391515&form=6&db=m Changes in signal transduction in Alzheimer's disease. ongoing research,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2684108&form=6&db=m Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137567&form=6&db=m Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7750571&form=6&db=m Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7891820&form=6&db=m Platelet protein kinase C levels in Alzheimer's disease. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7936052&form=6&db=m Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. diagnostic usage,ongoing research,unassigned 4,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100450&form=6&db=m Activation of protein kinase C increases the extracellular release of the transmembrane amyloid protein precursor of Alzheimer's disease. causal interaction,unassigned 1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8121626&form=6&db=m Effects of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8255461&form=6&db=m Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8327146&form=6&db=m Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8407946&form=6&db=m Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8469382&form=6&db=m Reduced membrane-associated protein kinase C(beta) immunoreactivity in the hippocampus of reserpinized rat brain. causal interaction,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569742&form=6&db=m Disturbances in signal transduction mechanisms in Alzheimer's disease. causal interaction,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8624109&form=6&db=m Defective protein kinase C alpha leads to impaired secretion of soluble beta-amyloid precursor protein from Alzheimer's disease fibroblasts. ongoing research,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8637611&form=6&db=m Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease. ongoing research,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8667008&form=6&db=m Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8746795&form=6&db=m Age does not alter Protein kinase C isozymes mRNA expression in rat brain. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8835644&form=6&db=m Assessment of protein kinase C mRNA levels in Alzheimer's disease brains. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109507&form=6&db=m Metabotropic glutamate receptors increase amyloid precursor protein processing in astrocytes: inhibition by cyclic AMP. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295195&form=6&db=m Protein kinase C activity and protein levels in Alzheimer's disease. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486481&form=6&db=m Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9661993&form=6&db=m Increased natural killer cell cytotoxicity in Alzheimer's disease may involve protein kinase C dysregulation. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9736660&form=6&db=m A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein. ongoing research,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9780084&form=6&db=m Protein kinase C-zeta activity but not level is decreased in Alzheimer's disease microvessels. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9848089&form=6&db=m Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10101252&form=6&db=m Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10321481&form=6&db=m Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells. causal interaction,unassigned 1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506528&form=6&db=m Protein kinase C anchoring deficit in postmortem brains of Alzheimer's disease patients. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10757536&form=6&db=m Phosphorylation of MARCKS in Alzheimer disease brains. causal interaction,unassigned 2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10789135&form=6&db=m [Reduced neuronal nitric oxide synthetase and c-protein kinase levels in Alzheimer's disease] causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11042363&form=6&db=m Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide. causal interaction,unassigned 1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158247&form=6&db=m Biphasic modulation of protein kinase C and enhanced cell toxicity by amyloid beta peptide and anoxia in neuronal cultures. causal interaction,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162589&form=6&db=m Blockade of PKC epsilon activation attenuates phorbol ester-induced increase of alpha-secretase-derived secreted form of amyloid precursor protein. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11856312&form=6&db=m NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473185&form=6&db=m Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14992812&form=6&db=m Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15893856&form=6&db=m Alteration of protein kinase C conformation in red blood cells: a potential marker for Alzheimer's disease but not for Parkinson's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691113&form=6&db=m Atypical protein kinase C in neurodegenerative disease I: PKMzeta aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer disease. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16828202&form=6&db=m Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892365&form=6&db=m Synthesis and Pharmacological Evaluation of 8- and 9-Substituted Benzolactam-V8 Derivatives as Potent Ligands for Protein Kinase C, a Therapeutic Target for Alzheimer's Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449873&form=6&db=m A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19850930&form=6&db=m Reduction of beta-amyloid levels by novel PKCepsilon activators. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895879&form=6&db=m Protein kinase C as a peripheral biomarker for Alzheimer's disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582866&form=6&db=m Drug Development for Neurodegenerative Diseases--Second Annual marcus evans Conference. Advances in drug development for NDD and expediting discovery through novel compounds and sound clinical trials. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21064191&form=6&db=m Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C? causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21679734&form=6&db=m Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21820649&form=6&db=m Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ?-mediated metalloproteinase 2 and 9 levels in ?-amyloid infused Alzheimer's disease rat model. ongoing research,unassigned 1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22539107&form=6&db=m Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C?. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22840750&form=6&db=m Activation of protein kinase C isozymes for the treatment of dementias. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949092&form=6&db=m Genistein Inhibits A?(25-35) -Induced Neurotoxicity in PC12 Cells via PKC Signaling Pathway. causal interaction,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23404502&form=6&db=m Sodium Phenylbutyrate Enhances Astrocytic Neurotrophin Synthesis via Protein Kinase C (PKC)-mediated Activation of cAMP-response Element-binding Protein (CREB): IMPLICATIONS FOR ALZHEIMER DISEASE THERAPY. therapeutic application,unassigned 2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23897302&form=6&db=m Peptide-based ligand screening and functional analysis of protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24172582&form=6&db=m Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24637095&form=6&db=m PKC activators enhance GABAergic neurotransmission and paired-pulse facilitation in hippocampal CA1 pyramidal neurons. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677503&form=6&db=m Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25114088&form=6&db=m Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25125477&form=6&db=m PKC? deficits in Alzheimer's disease brains and skin fibroblasts. causal interaction,unassigned 2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25710634&form=6&db=m Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogues for Analysis with Rotational Echo Double Resonance NMR Spectroscopy. causal interaction,unassigned 1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26197808&form=6&db=m Bioinformatics methods in drug repurposing for Alzheimer's disease. causal interaction,unassigned 2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26292580&form=6&db=m Structural insights into the interactions of phorbol ester and bryostatin complexed with protein kinase C: a comparative molecular dynamics simulation study. causal interaction,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590822&form=6&db=m Lack of overt genome reduction in the bryostatin-producing bryozoan symbiont, "Candidatus Endobugula sertula". causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28232750&form=6&db=m Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes. therapeutic application,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28482641&form=6&db=m Bryostatin Effects on Cognitive Function and PKC? in Alzheimer's Disease Phase IIa and Expanded Access Trials. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28671468&form=6&db=m Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29239334&form=6&db=m Calycosin improves cognitive function in a transgenic mouse model of Alzheimer's disease by activating the protein kinase C pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29710707&form=6&db=m Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus. causal interaction,unassigned 4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29920240&form=6&db=m Scallop-derived plasmalogens attenuate the activation of PKC? associated with the brain inflammation. causal interaction,unassigned 3,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30138694&form=6&db=m Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations. therapeutic application,unassigned 1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338269&form=6&db=m Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30687223&form=6&db=m Genetic Analysis of PICK1 Gene in Alzheimer's Disease: A Study for Finding a New Gene Target. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133106&form=6&db=m [Resveratrol upregulates the gene and protein expressions of N-methyl-D-aspartate receptor 1 and protein kinase C in the hippocampus in Alzheimer's disease rats]. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31304903&form=6&db=m Emodin attenuates Alzheimer's disease by activating the protein kinase C signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32512031&form=6&db=m Protein kinases A and C regulate amyloid-? degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33068318&form=6&db=m Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes. unassigned - 2.7.11.13 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33186918&form=6&db=m Molecular identification of protein kinase C beta in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.7.11.13 Amebiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2897334&form=6&db=m Phorbol esters specifically enhance the cytolytic activity of Entamoeba histolytica. unassigned - 2.7.11.13 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8204076&form=6&db=m Post-training intrahippocampal infusion of protein kinase C inhibitors causes amnesia in rats. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10677591&form=6&db=m Involvement of hippocampal PKCbetaI isoform in the early phase of memory formation of an inhibitory avoidance learning. therapeutic application,unassigned 2,0 2.7.11.13 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19757037&form=6&db=m Scopolamine Induced Amnesia is Reversed by Bacopa monniera Through Participation of Kinase-CREB Pathway. causal interaction,unassigned 2,0 2.7.11.13 Amyloidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7970175&form=6&db=m Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7488729&form=6&db=m [3H]phorbol 12,13-dibutyrate/PKC binding in thoracic spinal cord: no change in amyotrophic lateral sclerosis. unassigned - 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7616256&form=6&db=m A role for amplified protein kinase C activity in the pathogenesis of amyotrophic lateral sclerosis. unassigned - 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8936348&form=6&db=m Amyotrophic lateral sclerosis: the involvement of intracellular Ca2+ and protein kinase C. unassigned - 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9678513&form=6&db=m Decrease of protein kinase C in the spinal motor neurons of amyotrophic lateral sclerosis. ongoing research,unassigned 2,0 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649703&form=6&db=m Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease. ongoing research,unassigned 1,0 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15994023&form=6&db=m Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23436724&form=6&db=m Protein interacting with C kinase and neurological disorders. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904794&form=6&db=m Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970394&form=6&db=m Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14612194&form=6&db=m Identification of a binding site for the anti-inflammatory tripeptide feG. causal interaction,unassigned 1,0 2.7.11.13 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9357764&form=6&db=m Effects of PKC alpha activation on Ca2+ pump and K(Ca) channel in deoxygenated sickle cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10412047&form=6&db=m In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells. ongoing research,unassigned 4,0 2.7.11.13 Anemia, Iron-Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10412047&form=6&db=m In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells. ongoing research,unassigned 4,0 2.7.11.13 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8783639&form=6&db=m Sickle red blood cells stimulate endothelial cell production of eicosanoids and diacylglycerol. causal interaction,unassigned 2,0 2.7.11.13 Aniridia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8925665&form=6&db=m Comparison of protein kinase C subtype expression between normal and aniridic human ocular surfaces: implications for limbal stem cell dysfunction in aniridia. ongoing research,unassigned 3,0 2.7.11.13 Anorectal Malformations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32244197&form=6&db=m Upregulation of miR-92a-2-5p potentially contribute to anorectal malformations by inhibiting proliferation and enhancing apoptosis via PRKCA/?-catenin. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10048788&form=6&db=m Activation of phospholipase C and protein kinase C is required for expression of anthrax lethal toxin cytotoxicity in J774A.1 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,4,0 2.7.11.13 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17846295&form=6&db=m Differential protein kinase C isoform abundance in ascending aortic aneurysms from patients with bicuspid versus tricuspid aortic valves. ongoing research,unassigned 1,0 2.7.11.13 Aortic Coarctation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8206572&form=6&db=m Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594058&form=6&db=m Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Apnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175614&form=6&db=m Adenosine A3 receptors potentiate hippocampal calcium current by a PKA-dependent/PKC-independent pathway. therapeutic application,unassigned 1,0 2.7.11.13 Apnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12160963&form=6&db=m Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. unassigned - 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555083&form=6&db=m Angiotensin II modulates cardiac Na+ channels in neonatal rat. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11195788&form=6&db=m Protein kinase C is involved in cardioprotective effects of ischemic preconditioning on infarct size and ventricular arrhythmia in rats in vivo. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15611364&form=6&db=m Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide. therapeutic application,unassigned 1,0 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16945341&form=6&db=m Protective role of protein kinase C epsilon activation in ischemia-reperfusion arrhythmia. causal interaction,unassigned 2,0 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23141093&form=6&db=m [Activating protein kinase C enhances ventricular action potential duration restitution and increase arrhythmia susceptibility in Langendorff-perfused rabbit hearts]. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26981310&form=6&db=m Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27600718&form=6&db=m Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake. therapeutic application,unassigned 1,0 2.7.11.13 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785237&form=6&db=m PKC?II specifically regulates KCNQ1/KCNE1 channel membrane localization. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970286&form=6&db=m Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain. unassigned - 2.7.11.13 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1327876&form=6&db=m Regulation of 1 alpha, 25-dihydroxyvitamin D3 synthesis in macrophages from arthritic joints by phorbol ester, dibutyryl-cAMP and calcium ionophore (A23187). unassigned - 2.7.11.13 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8548359&form=6&db=m Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats. ongoing research,unassigned 2,0 2.7.11.13 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11345690&form=6&db=m In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719189&form=6&db=m Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.7.11.13 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19689371&form=6&db=m Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22842731&form=6&db=m The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22842731&form=6&db=m The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9562601&form=6&db=m Antiproliferative naphthopyrans: biological activity, mechanistic studies and therapeutic potential. therapeutic application,unassigned 3,0 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052323&form=6&db=m Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation. ongoing research,unassigned 2,0 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17957454&form=6&db=m Association and expression study of PRKCH gene in a French Caucasian population with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632643&form=6&db=m Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20646344&form=6&db=m Divergent effects of infliximab and anakinra therapies on macrophage phenotype from patients with refractory rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25982074&form=6&db=m Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27003097&form=6&db=m An Update on Calcineurin Inhibitor-Free Regimens: The Need Persists, but the Landscape has Changed. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30704835&form=6&db=m Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1920116&form=6&db=m Inhibition of airway smooth muscle tone by a phorbol ester in the guinea pig trachea: role of epithelium and receptor reserve of the contractile agent. causal interaction,unassigned 4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2485202&form=6&db=m The effect of smooth muscle relaxants working through different transduction mechanisms on the phorbol dibutyrate-induced contraction of the guinea-pig lung parenchymal strip: possible relevance for asthma. causal interaction,unassigned 3,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3040837&form=6&db=m Regulation of the beta-receptor-adenylate cyclase system in lymphocytes of allergic patients with asthma: possible role for protein kinase C in allergen-induced nonspecific refractoriness of adenylate cyclase. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7654381&form=6&db=m Expression of multiple isoenzymes of protein kinase C in airway smooth muscle. causal interaction,unassigned 4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8520736&form=6&db=m Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. ongoing research,unassigned 2,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9042625&form=6&db=m Increased levels of protein kinase C in lymphocytes in asthma: possible mechanism of regulation. causal interaction,unassigned 3,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9105056&form=6&db=m Cellular protein kinase C activity in asthma. causal interaction,unassigned 4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11802989&form=6&db=m [An experimental study on the regulation of the expression of Th2 cytokines by nuclear factor-kappaB and protein kinase C in asthma] ongoing research,unassigned 2,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12539551&form=6&db=m An experimental study on the regulation of expression of Th2 cytokines from T lymphocytes by protein kinase C in asthma. ongoing research,unassigned 2,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15634547&form=6&db=m [The effect of inhaled glucocorticosteroid on protein kinase Calpha expression and interleukin-5 production in induced sputum inflammatory cells of asthma patients] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987782&form=6&db=m Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16378110&form=6&db=m [Cross-talk between calcineurin and protein kinases in airway remodeling in asthma] causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956269&form=6&db=m Structure-based optimization of PKCtheta inhibitors. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783200&form=6&db=m Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors. diagnostic usage,therapeutic application,unassigned 3,4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19080278&form=6&db=m Role of protein kinase C alpha and cyclin D1 in the proliferation of airway smooth muscle in asthmatic rats. causal interaction,unassigned 4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19288034&form=6&db=m Therapeutic target validation of protein kinase C(PKC)-zeta for asthma using a mouse model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19689371&form=6&db=m Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20426528&form=6&db=m Up-regulation of cyclin D1 expression in asthma serum-sensitized human airway smooth muscle promotes proliferation via protein kinase C alpha. ongoing research,unassigned 1,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20816195&form=6&db=m Analyses of shared genetic factors between asthma and obesity in children. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21854185&form=6&db=m rhPLD2 suppresses chronic inflammation reactions in a guinea pig asthma model * diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22324796&form=6&db=m Bronchial inflammation induced PKC(?) over-expression: involvement in mechanical properties of airway smooth muscle. causal interaction,unassigned 4,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886957&form=6&db=m Effects of mitochondrial ATP-sensitive K(+) channel on protein kinase C pathway and airway smooth muscle cell proliferation in asthma. ongoing research,unassigned 1,0 2.7.11.13 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370642&form=6&db=m Comprehensive Account on the Synthesis of (-)-Balanol and its Analogues. causal interaction,unassigned 3,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316231&form=6&db=m Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656312&form=6&db=m Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662341&form=6&db=m cAMP-dependent down-regulation of endothelin-1 receptors on rat astrocytoma C6 cells. ongoing research,unassigned 1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1689454&form=6&db=m Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells. ongoing research,unassigned 2,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1720762&form=6&db=m Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2329505&form=6&db=m Activation of protein kinase C inhibits internalization and downregulation of muscarinic receptors in 1321N1 human astrocytoma cells. ongoing research,unassigned 4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2465997&form=6&db=m Astrocytes regulate GFAP mRNA levels by cyclic AMP and protein kinase C-dependent mechanisms. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2783692&form=6&db=m Increases in intracellular Ca2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells. ongoing research,unassigned 4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2892124&form=6&db=m Agonists and phorbol esters desensitize beta-adrenergic receptors by different mechanisms. ongoing research,unassigned 2,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521512&form=6&db=m Protein kinase C mediates delayed inhibitory feedback regulation of human neurokinin type 1 receptor activation of phospholipase C in UC11 astrocytoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7595543&form=6&db=m Tyrosine kinase activity is essential for interleukin-1 beta--stimulated production of interleukin-6 in U373 human astrocytoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8674728&form=6&db=m Protein kinase C modulation of phosphoinositidase C in 1321N1 human astrocytoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9504396&form=6&db=m Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9523575&form=6&db=m Substance P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6. ongoing research,unassigned 2,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9735396&form=6&db=m A novel approach for examining the anti-proliferative effect of protein kinase C inhibitors against human astrocytoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832394&form=6&db=m The role of protein kinase C alpha and epsilon isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line. causal interaction,unassigned 3,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9917510&form=6&db=m A high throughput system for the evaluation of protein kinase C inhibitors based on Elk1 transcriptional activation in human astrocytoma cells. unassigned - 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402232&form=6&db=m Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417813&form=6&db=m HIV-1 Nef alters the expression of betaII and epsilon isoforms of protein kinase C and the activation of the long terminal repeat promoter in human astrocytoma cells. ongoing research,unassigned 2,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10800962&form=6&db=m Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11020447&form=6&db=m Possible role of protein kinase C zeta in muscarinic receptor-induced proliferation of astrocytoma cells. ongoing research,unassigned 3,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254876&form=6&db=m Regulated expression of a dominant negative protein kinase C epsilon mutant inhibits the proliferation of U-373MG human astrocytoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324578&form=6&db=m [The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325] ongoing research,unassigned 4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389098&form=6&db=m Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483662&form=6&db=m Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861786&form=6&db=m Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020677&form=6&db=m Lithium chloride at a therapeutic concentration reduces Ca2+ response in protein kinase C down-regulated human astrocytoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12191496&form=6&db=m PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12520758&form=6&db=m Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome. causal interaction,unassigned 1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15093250&form=6&db=m Signal transduction mechanisms involved in the antiproliferative effects of ethanol in glial cells. causal interaction,unassigned 3,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15255942&form=6&db=m Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15317582&form=6&db=m Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475174&form=6&db=m Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells. ongoing research,unassigned 2,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701280&form=6&db=m Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15836614&form=6&db=m Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. ongoing research,unassigned 2,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16405508&form=6&db=m Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. ongoing research,unassigned 1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16527811&form=6&db=m Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16569497&form=6&db=m Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258372&form=6&db=m Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21787730&form=6&db=m Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25514083&form=6&db=m PKC? and PKC? Activation Regulates Transcriptional Activity and Degradation of Progesterone Receptor in Human Astrocytoma Cells. unassigned - 2.7.11.13 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168461&form=6&db=m Progesterone Receptor Together with PKC? Expression as Prognostic Factors for Astrocytomas Malignancy. therapeutic application,unassigned 1,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655168&form=6&db=m Inositol 1,4,5-trisphosphate receptors and protein kinase C in olivopontocerebellar atrophy. unassigned - 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12859346&form=6&db=m Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice. ongoing research,unassigned 4,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044634&form=6&db=m Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16189624&form=6&db=m A novel H101Q mutation causes PKCgamma loss in spinocerebellar ataxia type 14. causal interaction,unassigned 3,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17932622&form=6&db=m Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. unassigned - 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19561170&form=6&db=m Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin. therapeutic application,unassigned 1,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23026060&form=6&db=m Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24030789&form=6&db=m Clinical and Neurophysiological Profile of Four German Families with Spinocerebellar Ataxia Type 14. causal interaction,unassigned 3,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26041613&form=6&db=m Cerebellar neurochemical alterations in spinocerebellar ataxia type 14 appear to include glutathione deficiency. causal interaction,unassigned 3,0 2.7.11.13 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32976891&form=6&db=m Pharmacological and phosphoproteomic approaches to roles of protein kinase C in kappa opioid receptor-mediated effects in mice. therapeutic application,unassigned 1,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7478584&form=6&db=m Characterization of the signal transduction pathway mediating gamma ray-induced inhibition of DNA synthesis in human cells: indirect evidence for involvement of calmodulin but not protein kinase C nor p53. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7644499&form=6&db=m The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. therapeutic application,unassigned 1,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11298136&form=6&db=m Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia. causal interaction,unassigned 3,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014356&form=6&db=m PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. therapeutic application,unassigned 1,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16221682&form=6&db=m mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. causal interaction,unassigned 1,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20871480&form=6&db=m Human SMG-1 is Involved in Gemcitabine-Induced Primary microRNA-155/BIC Up-Regulation in Human Pancreatic Cancer PANC-1 Cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21930714&form=6&db=m Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31841199&form=6&db=m PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2346673&form=6&db=m Effect of trifluoperazine on DNA and LDL-receptor synthesis in smooth muscle cells exposed to hypercholesterolemic medium in vitro. unassigned - 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058653&form=6&db=m [Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8946264&form=6&db=m Basic research in antioxidant inhibition of steps in atherogenesis. therapeutic application,unassigned 2,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872935&form=6&db=m Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336880&form=6&db=m Vitamin E and vascular homeostasis: implications for atherosclerosis. causal interaction,unassigned 2,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10429471&form=6&db=m [Pathophysiology of vascular complications in diabetes] causal interaction,unassigned 4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12000746&form=6&db=m Activation of protein kinase Czeta is essential for cytokine-induced metalloproteinase-1, -3, and -9 secretion from rabbit smooth muscle cells and inhibits proliferation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646175&form=6&db=m Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells. ongoing research,unassigned 3,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14757978&form=6&db=m Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis: Role of vitamin E. therapeutic application,unassigned 1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15061918&form=6&db=m [Effects of dry red wine on experimental atherosclerosis in rabbits] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15286460&form=6&db=m Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial. unassigned - 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681696&form=6&db=m Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-kappaB signaling pathways. causal interaction,unassigned 4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113073&form=6&db=m ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy. causal interaction,unassigned 4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16640963&form=6&db=m Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16822947&form=6&db=m Nucleoside reverse transcriptase inhibitors prevent HIV protease inhibitor-induced atherosclerosis by ubiquitination and degradation of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084284&form=6&db=m Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis. therapeutic application,unassigned 1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17306850&form=6&db=m Activation of protein kinase C and disruption of endothelial monolayer integrity by sodium arsenite--Potential mechanism in the development of atherosclerosis. unassigned - 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19036858&form=6&db=m Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19327373&form=6&db=m Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19969380&form=6&db=m Protein kinase Calpha: disease regulator and therapeutic target. unassigned - 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192567&form=6&db=m Curcumin: from food spice to cancer prevention. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20932850&form=6&db=m 7-Ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21190563&form=6&db=m Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein G?11. causal interaction,unassigned 1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21624955&form=6&db=m PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. unassigned - 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287176&form=6&db=m Carotid atherosclerotic plaques: proteomics study after a low-abundance protein enrichment step. unassigned - 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23438954&form=6&db=m Fluid-Phase Pinocytosis of LDL by Macrophages: A Novel Target to Reduce Macrophage Cholesterol Accumulation in Atherosclerotic Lesions. unassigned - 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23766264&form=6&db=m PKC? promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice. causal interaction,unassigned 4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24440741&form=6&db=m Protein kinase C isoforms in atherosclerosis: pro- or anti-inflammatory? causal interaction,unassigned 4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30409037&form=6&db=m Type-2 diabetes mellitus and cardiovascular disease. causal interaction,unassigned 4,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31521120&form=6&db=m Molecular mechanisms of hydrogen sulfide against uremic accelerated atherosclerosis through cPKC?II/Akt signal pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32851658&form=6&db=m Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant-based bioactive compounds. therapeutic application,unassigned 1,0 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33822184&form=6&db=m Essential role of protein kinase C ?I in icariin-mediated protection against atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.7.11.13 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276388&form=6&db=m Potential Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14619582&form=6&db=m [Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation] diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909852&form=6&db=m Protein kinase C activation inhibits alpha1D L-type Ca channel: a single-channel analysis. causal interaction,unassigned 3,0 2.7.11.13 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33028764&form=6&db=m Binge Alcohol Exposure Triggers Atrial Fibrillation Through T-Type Ca2+ Channel Upregulation via Protein Kinase C (PKC) / Glycogen Synthesis Kinase 3? (GSK3?) / Nuclear Factor of Activated T-Cells (NFAT) Signaling?- An Experimental Account of Holiday Heart Syndrome. therapeutic application,unassigned 1,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1388634&form=6&db=m Avian scleroderma: evidence for qualitative and quantitative T cell defects. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861617&form=6&db=m Protein kinase C(theta) in T cell activation. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16493044&form=6&db=m Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase C{theta}-Deficient Mice. ongoing research,unassigned 4,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17544292&form=6&db=m Protein kinase C theta (PKCtheta): a key player in T cell life and death. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956269&form=6&db=m Structure-based optimization of PKCtheta inhibitors. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815612&form=6&db=m Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23398373&form=6&db=m Design and Optimization of Selective Protein Kinase C ? (PKC?) Inhibitors for the Treatment of Autoimmune Diseases. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27541826&form=6&db=m Protein Kinase C ?: a Gatekeeper of Immune Homeostasis. causal interaction,unassigned 1,0 2.7.11.13 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30274941&form=6&db=m A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 2.7.11.13 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11696589&form=6&db=m Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17346313&form=6&db=m Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465248&form=6&db=m Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121879&form=6&db=m Acid- and bile-induced PGE(2) release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent. unassigned - 2.7.11.13 Barth Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341795&form=6&db=m Reduced protein kinase C delta association with a higher molecular weight complex in mitochondria of Barth Syndrome lymphoblasts. diagnostic usage,unassigned 3,0 2.7.11.13 Blast Crisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14599545&form=6&db=m Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase-a potential reason for resistance to Glivec in chronic myelogenous leukaemia. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3138226&form=6&db=m Rapid screening method for inhibitors of protein kinase C. diagnostic usage,therapeutic application,unassigned 3,4,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7925852&form=6&db=m Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. ongoing research,unassigned 4,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8824829&form=6&db=m Structure-activity relationship within a series of degradation products of tautomycin. therapeutic application,unassigned 1,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9077478&form=6&db=m Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes. ongoing research,unassigned 4,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9772494&form=6&db=m [The effect of endothelin and protein kinase C on the vasoactive mechanisms of beta A(4)25-35 at skin microvasculature] ongoing research,unassigned 4,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16716901&form=6&db=m Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA. causal interaction,unassigned 1,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20486122&form=6&db=m Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21864491&form=6&db=m The Extent of Desmoglein 3 Depletion in Pemphigus Vulgaris Is Dependent on Ca(2+)-Induced Differentiation A Role in Suprabasal Epidermal Skin Splitting? causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11288038&form=6&db=m Effects of dietary restriction on appendicular bone in the SENCAR mouse. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20362561&form=6&db=m Involvement of the spinal NMDA receptor/PKCgamma signaling pathway in the development of bone cancer pain. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31567367&form=6&db=m Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144916&form=6&db=m [Bone-edge electroacupuncture relieves pain by regulating expression of GRK5, ?-arrestin 2 and PKC? proteins in locus coeruleus in bone cancer pain rats with morphine tolerance]. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320001&form=6&db=m Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone. ongoing research,unassigned 4,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1590794&form=6&db=m Role of protein kinase C (PKC) in bone resorption: effect of the specific PKC inhibitor 1-alkyl-2-methylglycerol. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1636672&form=6&db=m Protein kinase C affects microfilaments, bone resorption, and [Ca2+]o sensing in cultured osteoclasts. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1858848&form=6&db=m Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity. unassigned - 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2220263&form=6&db=m Calcitonin causes a sustained inhibition of protein kinase c-stimulated bone resorption in contrast to the transient inhibition of parathyroid hormone-induced bone resorption. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2356754&form=6&db=m 12-O-tetradecanoylphorbol-13-acetate, a phorbol ester stimulating protein kinase C, inhibits bone resorption in vitro induced by parathyroid hormone and parathyroid hormone-related peptide of malignancy. therapeutic application,unassigned 1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539969&form=6&db=m Effects of pertussis toxin on resorption of 19-day-old fetal rat long bones. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8030434&form=6&db=m Phorbol myristate acetate stimulates osteoclast formation in 1 alpha,25-dihydroxyvitamin D3-primed mouse embryonic calvarial cells by a prostaglandin-dependent mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569546&form=6&db=m Anabolic effects of insulin on bone suggest a role for chromium picolinate in preservation of bone density. therapeutic application,unassigned 1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8687978&form=6&db=m Effect of diacylglycerols on osteoclastic bone resorption. unassigned - 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8997387&form=6&db=m Parathyroid hormone-induced calcium efflux from cultured bone is mediated by protein kinase C translocation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9112415&form=6&db=m Ca2+ or phorbol ester but not inflammatory stimuli elevate inducible nitric oxide synthase messenger ribonucleic acid and nitric oxide (NO) release in avian osteoclasts: autocrine NO mediates Ca2+-inhibited bone resorption. therapeutic application,unassigned 1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592034&form=6&db=m Bone resorption induced by A23187 is abolished by indomethacin: implications for second messenger utilised by parathyroid hormone. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10974200&form=6&db=m Divergent effects of protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I (GF109203X) on bone resorption. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11206583&form=6&db=m Tamoxifen inhibits phorbol ester stimulated osteoclastic bone resorption: an effect mediated by calmodulin. causal interaction,unassigned 1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667143&form=6&db=m Differential effects of calmodulin and protein kinase C antagonists on bone resorption and acid transport activity. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14672351&form=6&db=m 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation. therapeutic application,unassigned 3,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476589&form=6&db=m Rho and Rho kinase are involved in parathyroid hormone-stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014375&form=6&db=m A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. ongoing research,unassigned 2,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25363829&form=6&db=m Protein Kinase C Inhibitor, GF109203X Attenuates Osteoclastogenesis, Bone Resorption and RANKL-Induced NF-?B and NFAT Activity. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28621479&form=6&db=m 12-O-tetradecanoylphorbol-13-acetate (TPA) Inhibits Osteoclastogenesis by Suppressing RANKL-Induced NF-?B Activation. therapeutic application,unassigned 2,0 2.7.11.13 Borna Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552443&form=6&db=m Borna Disease Virus Blocks Potentiation of Presynaptic Activity through Inhibition of Protein Kinase C Signaling. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Borna Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424436&form=6&db=m Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Borna Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29378968&form=6&db=m Hippocampal expression of a virus-derived protein impairs memory in mice. unassigned - 2.7.11.13 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158048&form=6&db=m The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.7.11.13 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996892&form=6&db=m Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway. causal interaction,unassigned 1,0 2.7.11.13 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172449&form=6&db=m The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability. therapeutic application,unassigned 2,0 2.7.11.13 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097471&form=6&db=m Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27647375&form=6&db=m Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29744369&form=6&db=m Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice. causal interaction,unassigned 2,0 2.7.11.13 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34500285&form=6&db=m The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2758320&form=6&db=m Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley CFY rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863219&form=6&db=m [Effects of inhibitor of protein kinase C on brain edema formation evoked by experimental cerebral ischemia in gerbils and rats] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16671466&form=6&db=m Effect of dimethyl sulfoxide on blood-brain barrier integrity following middle cerebral artery occlusion in the rat. diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16671492&form=6&db=m Modulation of AQP4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema. ongoing research,unassigned 2,0 2.7.11.13 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21038114&form=6&db=m The effects of protein kinase C activator phorbol dibutyrate on traumatic brain edema and aquaporin-4 expression. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19198108&form=6&db=m [Molecular epidemiology of cerebrovascular diseases; the Hisayama study and the Fukuoka Stroke Registry (FSR)] therapeutic application,unassigned 1,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7583321&form=6&db=m Relationship between opioids and activation of phospholipase C and protein kinase C in brain injury induced pial artery vasoconstriction. causal interaction,unassigned 2,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861605&form=6&db=m Alterations in brain protein kinase C after experimental brain injury. diagnostic usage,therapeutic application,unassigned 4,1,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9565969&form=6&db=m Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways. causal interaction,unassigned 2,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9880404&form=6&db=m Superoxide generation links protein kinase C activation to impaired ATP-sensitive K+ channel function after brain injury. causal interaction,unassigned 2,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12123546&form=6&db=m Roles of protein kinase C and inositol(1,4,5)-trisphosphate in the pathogenesis of hypoxic- ischemic brain injury in neonatal rats. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12652005&form=6&db=m Perspectives on reperfusion-induced damage in rodent models of experimental focal ischemia and role of gamma-protein kinase C. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706231&form=6&db=m Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21172324&form=6&db=m The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKC?/PKC? signaling. ongoing research,unassigned 2,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26617735&form=6&db=m Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385957&form=6&db=m The role of protein kinase C in ischemic tolerance induced by hyperoxia in rats with stroke. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29623912&form=6&db=m Cerebral ischemia and neuroregeneration. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30542270&form=6&db=m Protein Kinase C Inhibition Mediates Neuroblast Enrichment in Mechanical Brain Injuries. unassigned - 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7861445&form=6&db=m Endogenous phosphorylation of a 61,000 dalton hippocampal protein increases following traumatic brain injury. causal interaction,unassigned 4,0 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8258841&form=6&db=m Alterations of protein kinase C in rat hippocampus following traumatic brain injury. ongoing research,unassigned 1,0 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782666&form=6&db=m NOC/oFQ activates PKC and generates superoxide to impair hypotensive cerebrovasodilation after hypoxia/ischemia. ongoing research,unassigned 1,0 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17105827&form=6&db=m peroxisome proliferator-activated receptor alpha activation-mediated regulation of endothelin-1 production via nitric oxide and protein kinase C signaling pathways in piglet cerebral microvascular endothelial cell culture. causal interaction,unassigned 2,0 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19233655&form=6&db=m Neuroprotective versus tumorigenic protein kinase C activators. therapeutic application,unassigned 1,0 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19644508&form=6&db=m PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma. ongoing research,unassigned 2,0 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22275068&form=6&db=m The binding affinities of proteins interacting with the PDZ domain of PICK1. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24172582&form=6&db=m Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1356340&form=6&db=m Postreceptor modulation of cAMP accumulation in rat brain particulate fraction after ischemia--involvement of protein kinase C. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1520407&form=6&db=m Protein kinase C activity in permanent focal cerebral ischemia. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1528172&form=6&db=m Expression of protein kinase C in postischemic brain: an in situ hybridization study. causal interaction,unassigned 4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1548477&form=6&db=m Effect of brain ischemia on protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1804660&form=6&db=m Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1919586&form=6&db=m Hypothermia prevents the ischemia-induced translocation and inhibition of protein kinase C in the rat striatum. ongoing research,unassigned 4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1997499&form=6&db=m Autoradiographic analysis on second-messenger systems and local cerebral blood flow in ischemic gerbil brain. diagnostic usage,unassigned 2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2002338&form=6&db=m Changes in the activity of protein kinase C and the differential subcellular redistribution of its isozymes in the rat striatum during and following transient forebrain ischemia. ongoing research,unassigned 2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2230806&form=6&db=m Decreased protein kinase C activity during cerebral ischemia and after reperfusion in the adult rat. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2280899&form=6&db=m Protein kinase C is translocated to cell membranes during cerebral ischemia. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2370943&form=6&db=m Altered protein kinase C activity in different subfields of hippocampus following cerebral ischemia. therapeutic application,unassigned 1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3198627&form=6&db=m Protein kinase C alterations in the fetal rat brain after global ischemia. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7745616&form=6&db=m Modulation of ischemic signal by antagonists of N-methyl-D-aspartate, nitric oxide synthase, and platelet-activating factor in gerbil hippocampus. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8090367&form=6&db=m Enhanced maximal binding capacity (Bmax) of second messenger ligand in the acute phase of cerebral ischemia--direct visualization by digital image analysis. causal interaction,unassigned 3,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8376989&form=6&db=m Time course of the translocation and inhibition of protein kinase C during complete cerebral ischemia in the rat. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769854&form=6&db=m An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8815904&form=6&db=m Specific induction of protein kinase C delta subspecies after transient middle cerebral artery occlusion in the rat brain: inhibition by MK-801. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9084410&form=6&db=m Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons. causal interaction,unassigned 1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9452194&form=6&db=m Alteration of protein kinase C activity after transient focal cerebral ischemia in mice using in vitro [3H]phorbol-12,13-dibutyrate binding autoradiography. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9660402&form=6&db=m Protein kinase C expression and activity after global incomplete cerebral ischemia in dogs. therapeutic application,unassigned 1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863219&form=6&db=m [Effects of inhibitor of protein kinase C on brain edema formation evoked by experimental cerebral ischemia in gerbils and rats] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886060&form=6&db=m Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9931492&form=6&db=m Isoform-specific translocation of protein kinase C following glutamate administration in primary hippocampal neurons. ongoing research,unassigned 4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10592293&form=6&db=m Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10616797&form=6&db=m Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11166693&form=6&db=m Isoforms of protein kinase C in postsynaptic densities after cerebral ischemia. therapeutic application,unassigned 2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11700956&form=6&db=m Isoform-specific membrane translocation of protein kinase C after ischemic preconditioning. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871585&form=6&db=m Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266902&form=6&db=m Vasopressin mediates neuroprotection in mice by stimulation of V1 vasopressin receptors: influence of PI-3 kinase and gap junction inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15295022&form=6&db=m Protein kinase C delta mediates cerebral reperfusion injury in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716854&form=6&db=m Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857391&form=6&db=m Involvement of gamma protein kinase C in estrogen-induced neuroprotection against focal brain ischemia through G protein-coupled estrogen receptor. therapeutic application,unassigned 3,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115018&form=6&db=m Role of reactive oxygen species and protein kinase C in ischemic tolerance in the brain. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16406313&form=6&db=m Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204679&form=6&db=m Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17212812&form=6&db=m Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293847&form=6&db=m Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17988655&form=6&db=m epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032736&form=6&db=m Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473171&form=6&db=m Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428821&form=6&db=m Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21183751&form=6&db=m Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1. ongoing research,unassigned 4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21318404&form=6&db=m Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood-Brain Barrier in a Focal Cerebral Ischemic Insult. therapeutic application,unassigned 1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21710361&form=6&db=m Recombinant Human Angiopoietin-1 Ameliorates the Expressions of ZO-1, Occludin, VE-cadherin, and PKC? Signaling after Focal Cerebral Ischemia/Reperfusion in Rats. ongoing research,unassigned 4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21789211&form=6&db=m Activation of Protein Kinase C Delta following Cerebral Ischemia Leads to Release of Cytochrome C from the Mitochondria via Bad Pathway. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865497&form=6&db=m Limb Remote Postconditioning Alleviates Cerebral Reperfusion Injury Through Reactive Oxygen Species-Mediated Inhibition of Delta Protein Kinase C in Rats. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22840750&form=6&db=m Activation of protein kinase C isozymes for the treatment of dementias. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23140054&form=6&db=m [Effect of electroacupuncture on cerebral PKC isozyme expression levels in cerebral ischemia-reperfusion rats]. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23870286&form=6&db=m Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling. therapeutic application,unassigned 2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24530291&form=6&db=m Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. therapeutic application,unassigned 2,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26617735&form=6&db=m Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26644690&form=6&db=m Protection mechanism of early hyperbaric oxygen therapy in rats with permanent cerebral ischemia. causal interaction,unassigned 1,0 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27435822&form=6&db=m Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5. unassigned - 2.7.11.13 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29623912&form=6&db=m Cerebral ischemia and neuroregeneration. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656312&form=6&db=m Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2750486&form=6&db=m Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7838340&form=6&db=m Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858877&form=6&db=m Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. causal interaction,unassigned 3,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927633&form=6&db=m Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402232&form=6&db=m Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254876&form=6&db=m Regulated expression of a dominant negative protein kinase C epsilon mutant inhibits the proliferation of U-373MG human astrocytoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389098&form=6&db=m Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15072444&form=6&db=m Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15934917&form=6&db=m PKCeta as a therapeutic target in glioblastoma multiforme. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19421003&form=6&db=m Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila. therapeutic application,unassigned 1,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19761816&form=6&db=m Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25514083&form=6&db=m PKC? and PKC? Activation Regulates Transcriptional Activity and Degradation of Progesterone Receptor in Human Astrocytoma Cells. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1321770&form=6&db=m Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1356626&form=6&db=m Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1360235&form=6&db=m Involvement of protein kinase C in the growth regulation of human breast cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1362242&form=6&db=m Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1617646&form=6&db=m Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1737390&form=6&db=m Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1738150&form=6&db=m Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2222428&form=6&db=m Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2317779&form=6&db=m Changes in diacylglycerol and membrane associated protein kinase C activity reflect the growth status of xenografted human mammary carcinoma treated with 8-Cl-cAMP. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2474538&form=6&db=m Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2535880&form=6&db=m Prognostic significance of mRNA-encoding estrogen receptor and epithelial growth factor receptor in breast carcinoma progression into lymph nodes: 1. Estrogen receptor encoding mRNA. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2720675&form=6&db=m Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3008998&form=6&db=m Epidermal growth factor binding and protein kinase C activities in human breast cancer cell lines: possible quantitative relationship. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3022916&form=6&db=m Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3353368&form=6&db=m Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3358773&form=6&db=m The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3386247&form=6&db=m Enhanced phosphorylation of progesterone receptor by protein kinase C in human breast cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422442&form=6&db=m Phorbol esters induce multidrug resistance in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3513765&form=6&db=m Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3709798&form=6&db=m Activation by phorbol esters of protein kinase C in MCF-7 human breast cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491298&form=6&db=m Unsaturated fatty acid effects on human breast cancer cell adhesion. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7536688&form=6&db=m Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7560079&form=6&db=m Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death. ongoing research,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7669076&form=6&db=m Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706498&form=6&db=m MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7819137&form=6&db=m Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981456&form=6&db=m Alternative mechanisms of action of anti-oestrogens. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7986752&form=6&db=m Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100351&form=6&db=m Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8112895&form=6&db=m The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8313530&form=6&db=m No tumor-specific expression levels of protein kinase C isoenzymes and of c-fos in human breast cancer cell cultures. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8339066&form=6&db=m The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8461257&form=6&db=m Relative involvement of protein kinase C and of the estrogen receptor in the cytotoxic action of a population of triphenylethylenes on MCF7 cells as revealed by correspondence factorial (CF) analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8496705&form=6&db=m Tricolorin A, major phytogrowth inhibitor from Ipomoea tricolor. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8567666&form=6&db=m Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8616873&form=6&db=m Regulation of the adhesion of a human breast carcinoma cell line to type IV collagen and vitronectin: roles for lipoxygenase and protein kinase C. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8645607&form=6&db=m Dual regulation of the epidermal growth factor family of growth factors in breast cancer by sex steroids and protein kinase C. causal interaction,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662863&form=6&db=m Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8687492&form=6&db=m Selective inhibition of the effects of phorbol ester on doxorubicin resistance and P-glycoprotein by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) in multidrug-resistant MCF-7/Dox human breast carcinoma cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8782659&form=6&db=m Regulation of arachidonic acid metabolism, aromatase activity and growth in human breast cancer cells by interleukin-1beta and phorbol ester: dissociation of a mediatory role for prostaglandin E2 in the autocrine control of cell function. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8824346&form=6&db=m Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)- hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8826643&form=6&db=m Protein kinase C and breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8877100&form=6&db=m Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9135029&form=6&db=m Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9146728&form=6&db=m Elevated levels of ERK2 in human breast carcinoma MCF-7 cells transfected with protein kinase C alpha. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9155054&form=6&db=m Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9201251&form=6&db=m Increased phospholipase D activity in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9246607&form=6&db=m Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272125&form=6&db=m An N-myristoylated protein kinase C-alpha pseudosubstrate peptide that functions as a multidrug resistance reversal agent in human breast cancer cells is not a P-glycoprotein substrate. therapeutic application,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9284950&form=6&db=m Retinoic acid induced growth arrest of human breast carcinoma cells requires protein kinase C alpha expression and activity. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344462&form=6&db=m Expression of protein kinase C-beta promotes the stimulatory effect of phorbol ester on phosphatidylethanolamine synthesis. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9348112&form=6&db=m Selective modulation of protein kinase A and protein kinase C activities in epidermal growth factor (EGF)-stimulated MCF-7 breast cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443937&form=6&db=m The involvement of novel protein kinase C isozymes in influencing sensitivity of breast cancer MCF-7 cells to tumor necrosis factor-alpha. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9495244&form=6&db=m Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9582012&form=6&db=m Association of PKC delta and active Src in PMA-treated MCF-7 human breast cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592198&form=6&db=m Protein kinase C and its isoforms in human breast cancer cells: relationship to the invasive phenotype. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593849&form=6&db=m Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9596483&form=6&db=m Differential effects of protein kinase C agonists on prostaglandin production and growth in human breast cancer cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9714066&form=6&db=m Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF-7 human breast cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815959&form=6&db=m Bryostatin 1 affects P-glycoprotein phosphorylation but not function in multidrug-resistant human breast cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9837921&form=6&db=m Telomerase is controlled by protein kinase Calpha in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9879662&form=6&db=m Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10047452&form=6&db=m Regulation of motility and protease expression in PKC-mediated induction of MCF-7 breast cancer cell invasiveness. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10094832&form=6&db=m Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10200347&form=6&db=m Isolation of protein kinase C-alpha-regulated cDNAs associated with breast tumor aggressiveness by differential mRNA display. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10221776&form=6&db=m Regulation of protein kinase C delta by estrogen in the MCF-7 human breast cancer cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10355743&form=6&db=m Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375605&form=6&db=m Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10399957&form=6&db=m Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449615&form=6&db=m A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC-betaII. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10544966&form=6&db=m Biochemical requirements for the expression of heat shock protein 72 kda in human breast cancer MCF-7 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567214&form=6&db=m Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and phosphatidylinositol 3-kinase. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10663644&form=6&db=m Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10811993&form=6&db=m Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10830573&form=6&db=m Biological mechanisms in breast cancer invasiveness: relevance to preventive interventions. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952784&form=6&db=m Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078811&form=6&db=m Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11085941&form=6&db=m Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11112424&form=6&db=m Overexpression of protein kinase C-eta attenuates caspase activation and tumor necrosis factor-alpha-induced cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115559&form=6&db=m Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162606&form=6&db=m Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11326671&form=6&db=m Ex vivo assays to evaluate the role of protein kinase C in tumor cells of patients with breast cancer. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11371124&form=6&db=m Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11467396&form=6&db=m Heterogeneity of proteinkinase C activity and PKC-zeta expression in clinical breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11488907&form=6&db=m Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11501838&form=6&db=m Cyclooxygenase-2, P-glycoprotein-170 and drug resistance; is chemoprevention against multidrug resistance possible? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11525643&form=6&db=m Protein kinase Calpha expression confers retinoic acid sensitivity on MDA-MB-231 human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11561774&form=6&db=m Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595128&form=6&db=m A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595710&form=6&db=m Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11713593&form=6&db=m Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11727958&form=6&db=m Altered expression and localization of PKC eta in human breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11767000&form=6&db=m Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11960991&form=6&db=m Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12056641&form=6&db=m Protein kinase C involvement in proliferation and survival of breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068001&form=6&db=m Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12138200&form=6&db=m Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12163680&form=6&db=m Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269833&form=6&db=m Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12379472&form=6&db=m Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12490289&form=6&db=m Alterations in skeletal protein, distribution of PKCalpha, and level of phospholipids in erythrocyte membranes of women with primary breast cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12548864&form=6&db=m [Effects of inhibition of PKC alpha on breast cancer cell phenotype and expressions of cyclin E and CDK2] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628005&form=6&db=m Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12632071&form=6&db=m Protein kinase Calpha regulates Ets1 transcriptional activity in invasive breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657722&form=6&db=m Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12697687&form=6&db=m Estrogen-dependent rapid activation of protein kinase C in estrogen receptor-positive MCF-7 breast cancer cells and estrogen receptor-negative HCC38 cells is membrane-mediated and inhibited by tamoxifen. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12722024&form=6&db=m Antisense therapy directed to protein kinase C-alpha (Affinitak, LY900003/ISIS 3521): potential role in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778068&form=6&db=m Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805378&form=6&db=m Activation of protein kinase C delta by all-trans-retinoic acid. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811511&form=6&db=m Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811831&form=6&db=m Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12878187&form=6&db=m Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14517342&form=6&db=m Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587095&form=6&db=m Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607845&form=6&db=m Requirement of protein kinase C micro activation and calpain-mediated proteolysis for arachidonic acid-stimulated adhesion of MDA-MB-435 human mammary carcinoma cells to collagen type IV. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14641818&form=6&db=m Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14966210&form=6&db=m Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014360&form=6&db=m Dysregulation of protein kinase C activity in chemoresistant metastatic breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240094&form=6&db=m Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289868&form=6&db=m Deregulation of PKB influences antiapoptotic signaling by PKC in breast cancer cells. therapeutic application,unassigned 2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375488&form=6&db=m Gene regulation by phorbol 12-myristate 13-acetate in MCF-7 and MDA-MB-231, two breast cancer cell lines exhibiting highly different phenotypes. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15389378&form=6&db=m Importance of ets1 proto-oncogene for breast cancer progression. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459489&form=6&db=m Protein kinase C alpha expression in breast and ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531915&form=6&db=m Ets1 is an effector of protein kinase Calpha in cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625563&form=6&db=m Contribution of protein kinase A and protein kinase C signalling pathways to the regulation of HSD11B2 expression and proliferation of MCF-7 cells. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649406&form=6&db=m PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15735031&form=6&db=m Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15735693&form=6&db=m Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15887250&form=6&db=m Atypical PKC-zeta and PKC-iota mediate opposing effects on MCF-7 Na+/K+ATPase activity. ongoing research,unassigned 2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16012735&form=6&db=m Antineoplaston induces G(1) arrest by PKCalpha and MAPK pathway in SKBR-3 breast cancer cells. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166314&form=6&db=m Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230781&form=6&db=m Potentiation of genomic actions of estrogen by membrane actions in mcf-7 cells and the involvement of protein kinase C activation. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407820&form=6&db=m Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513679&form=6&db=m Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16580129&form=6&db=m Hormonal regulation of PKC: estrogen up-regulates PKCeta expression in estrogen-responsive breast cancer cells. therapeutic application,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16617167&form=6&db=m Protein kinase C delta mediates platelet-induced breast cancer cell invasion. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797377&form=6&db=m Protein kinase C-beta as a therapeutic target in breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030510&form=6&db=m Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. ongoing research,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17061041&form=6&db=m Protein Kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145886&form=6&db=m Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17171646&form=6&db=m Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17186022&form=6&db=m Downregulation of Bid is associated with PKCepsilon-mediated TRAIL resistance. therapeutic application,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17219421&form=6&db=m Protein kinase C delta enhances proliferation and survival of murine mammary cells. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17240347&form=6&db=m Development of a microscopy-based assay for protein kinase Czeta activation in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545611&form=6&db=m Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17666590&form=6&db=m Direct Binding and Activation of Protein Kinase C Isoforms by Aldosterone and 17{beta}-Estradiol. therapeutic application,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17965220&form=6&db=m Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18037997&form=6&db=m PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18184652&form=6&db=m Protein Kinase C{epsilon} Mediates Polymeric Fibronectin Assembly on the Surface of Blood-borne Rat Breast Cancer Cells to Promote Pulmonary Metastasis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18224398&form=6&db=m Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317451&form=6&db=m Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336267&form=6&db=m Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18425734&form=6&db=m A short peptide is a protein kinase C (PKC) alpha-specific substrate. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448327&form=6&db=m Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C. therapeutic application,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18538170&form=6&db=m The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. causal interaction,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132529&form=6&db=m Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201988&form=6&db=m Pivotal Advance: PKC{zeta} is required for migration of macrophages. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19214387&form=6&db=m A phase II study of oral enzastaurin in patients with metastatic breast cancer previously treated with an anthracycline and a taxane containing regimen. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19324060&form=6&db=m Protein kinases C isozymes are differentially expressed in human breast carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19406749&form=6&db=m Phosphorylation of alpha 6-tubulin by protein kinase Calpha activates motility of human breast cells. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19531564&form=6&db=m Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633292&form=6&db=m Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microrna-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. diagnostic usage,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19838949&form=6&db=m Stearate preferentially induces apoptosis in human breast cancer cells. therapeutic application,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903772&form=6&db=m p34SEI-1 inhibits doxorubicin-induced senescence through a pathway mediated by protein kinase C-delta and c-Jun-NH2-kinase 1 activation in human breast cancer MCF7 cells. ongoing research,unassigned 2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996302&form=6&db=m Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20099025&form=6&db=m Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145126&form=6&db=m Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20198332&form=6&db=m PKCepsilon induces Bcl-2 by activating CREB. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20384629&form=6&db=m Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398285&form=6&db=m PKCalpha expression is a marker for breast cancer aggressiveness. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20407013&form=6&db=m Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20665667&form=6&db=m Protein kinase C? and caspase-3 modulate TRAIL-induced apoptosis in breast tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20856202&form=6&db=m Sustained inhibition of PKC? reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533346&form=6&db=m Expression of the invasive phenotype by MCF-7 human breast cancer cells transfected to overexpress protein kinase C-alpha or the erbB2 proto-oncogene. ongoing research,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21630460&form=6&db=m Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21712053&form=6&db=m Protein kinase C ? regulates nuclear pri-microRNA 15a release as part of endothelin signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21720730&form=6&db=m Protein kinase C? suppresses the expression of STC1 in MDA-MB-231 breast cancer cells. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21860415&form=6&db=m Macrophage-elicited loss of estrogen receptor-? in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus. causal interaction,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22213077&form=6&db=m Type V collagen and protein kinase C ? down-regulation in 8701-BC breast cancer cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22247547&form=6&db=m Membrane Estrogen Signaling Enhances Tumorigenesis and Metastatic Potential of Breast Cancer Cells via Estrogen Receptor-?36 (ER?36). unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427054&form=6&db=m Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464443&form=6&db=m ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22710801&form=6&db=m PICK1 promotes caveolin-dependent degradation of TGF-? type I receptor. causal interaction,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22911661&form=6&db=m Preferential star strand biogenesis of pre-miR-24-2 targets PKC-alpha and suppresses cell survival in MCF-7 breast cancer cells. ongoing research,unassigned 2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23091071&form=6&db=m Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23262036&form=6&db=m Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23474764&form=6&db=m Protein kinase C? is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23634843&form=6&db=m Extranuclear ER? is associated with regression of T47D PKC?-overexpressing, tamoxifen-resistant breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23783392&form=6&db=m Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24029232&form=6&db=m Protein Kinase C ? Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753582&form=6&db=m Control of MT1-MMP transport by atypical PKC during breast-cancer progression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24786829&form=6&db=m PKC?/? signaling promotes triple-negative breast cancer growth and metastasis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24795864&form=6&db=m Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis. causal interaction,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24838400&form=6&db=m Involvement of protein kinase C ? and ? activities on the induction of the retinoic acid system in mammary cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26044736&form=6&db=m Aurora kinases are essential for PKC-induced invasion and matrix metalloproteinase-9 expression in MCF-7 breast cancer cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26063340&form=6&db=m P2Y2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells. causal interaction,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083392&form=6&db=m Down Regulation of CLDND1 Induces Apoptosis in Breast Cancer Cells. causal interaction,unassigned 2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970394&form=6&db=m Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27127545&form=6&db=m Cross Talk Mechanism among EMT, ROS, and Histone Acetylation in Phorbol Ester-Treated Human Breast Cancer MCF-7 Cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27551497&form=6&db=m PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27633567&form=6&db=m Correction: Novel Antitumor Effect of Estradiol in Athymic Mice Injected with a T47D Breast Cancer Cell Line Overexpressing Protein Kinase C Alpha. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27657337&form=6&db=m Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053624&form=6&db=m Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis. causal interaction,unassigned 1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29036789&form=6&db=m Protein kinase C ?-dependent regulation of Ubiquitin-proteasome system function in breast cancer. ongoing research,unassigned 2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29216867&form=6&db=m Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29219195&form=6&db=m Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29658601&form=6&db=m Silencing of casein kinase 2 inhibits PKC?induced cell invasion by targeting MMP?9 in MCF?7 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,2 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30062522&form=6&db=m Classical Protein Kinase C: a novel kinase target in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30562553&form=6&db=m Differential effects of protein kinase C-eta on apoptosis versus senescence. causal interaction,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516713&form=6&db=m Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31543517&form=6&db=m Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC. diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31699818&form=6&db=m aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32128390&form=6&db=m Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. unassigned - 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194726&form=6&db=m MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32336285&form=6&db=m miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32456148&form=6&db=m Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865619&form=6&db=m Protein Kinase C Alpha (PKC?) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RAR?) activation in mammary cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438870&form=6&db=m Switch to Hypomania After Discontinuation of Tamoxifen: A Case Report. therapeutic application,unassigned 4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33490232&form=6&db=m Unravelling Structure, Localization, and Genetic Crosstalk of KLF3 in Human Breast Cancer. ongoing research,unassigned 3,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524008&form=6&db=m Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576006&form=6&db=m Crosstalk between miR-203 and PKC? regulates breast cancer stem cell markers. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33723318&form=6&db=m All-trans retinoic acid and protein kinase C ?/?1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34408972&form=6&db=m Inhibition of PKC/MEK pathway suppresses ?1-integrin and mitigates breast cancer cells proliferation. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Bronchiolitis Obliterans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16974846&form=6&db=m Anti-airway epithelial cell antibody binding results in protein kinase C activation and fibrotic growth factor production contributing to pathogenesis of bronchiolitis obliterans. causal interaction,unassigned 1,0 2.7.11.13 Burkholderia Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28638804&form=6&db=m PKC-?-MARCKS Signaling Promotes Intracellular Survival of Unopsonized Burkholderia thailandensis. causal interaction,unassigned 4,0 2.7.11.13 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8299681&form=6&db=m The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15028022&form=6&db=m Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1437643&form=6&db=m Effects of a long-chain fatty amine on mammary carcinogenesis induced in female Sprague-Dawley rats by DMBA. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1516053&form=6&db=m Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559225&form=6&db=m Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1618921&form=6&db=m Effects of acute vs. chronic phorbol ester exposure on transepithelial permeability and epithelial morphology. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1727670&form=6&db=m Protein kinase C activity in human colonic adenoma and colorectal carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1773790&form=6&db=m Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control. ongoing research,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908847&form=6&db=m Changes in carboxylesterase isoenzymes of rat liver microsomes during hepatocarcinogenesis. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1986745&form=6&db=m Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C. therapeutic application,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119643&form=6&db=m The role of protein kinase C in growth control and the concept of carcinogenesis as a progressive disorder in signal transduction. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2186310&form=6&db=m The influence of dietary fat on carcinogenesis: lessons from experimental models. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2256926&form=6&db=m Purification and identification of creatine phosphokinase B as a substrate of protein kinase C in mouse skin in vivo. ongoing research,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2315961&form=6&db=m Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546729&form=6&db=m [The role of protein kinase C in tumor growth] causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827905&form=6&db=m Effect of diterpene esters on actin cytoskeleton of SV40-transformed keratinocytes is not reproduced by diacylglycerols. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2857174&form=6&db=m Protein kinase C catalyzes phosphorylation of guanylate cyclase in vitro. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2870684&form=6&db=m [The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion] diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2917651&form=6&db=m 1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity? unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2955833&form=6&db=m Phorbol esters as signal transducers and tumor promoters. causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000588&form=6&db=m Stimulation of cell proliferation and inhibition of differentiation expression by tumor-promoting phorbol esters in dog thyroid cells in primary culture. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3079908&form=6&db=m Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3689124&form=6&db=m Studies on protein kinase C and colon carcinogenesis. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4053047&form=6&db=m Decrease in the protein kinase C-catalyzed phosphorylation of an endogenous lung protein (Mr 36,000) following treatment of mice with the tumor-modulatory agent butylated hydroxytoluene. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7512536&form=6&db=m Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: effects of fatty acids and cyclooxygenase inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585521&form=6&db=m Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585585&form=6&db=m Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7586172&form=6&db=m Gender-specific and developmental differences in protein kinase C isozyme expression in rat liver. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7658500&form=6&db=m Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7672695&form=6&db=m Suppression of calphobindin I (CPB I) production in carcinoma of uterine cervix and endometrium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7673165&form=6&db=m Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. ongoing research,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7767990&form=6&db=m Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7782924&form=6&db=m Dietary modulation of epidermal protein kinase C: mediation by diacylglycerol. therapeutic application,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7817999&form=6&db=m Analyses of protein kinase C isoform expression in a colorectal cancer liver metastasis model. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931620&form=6&db=m The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7972255&form=6&db=m Protein kinase C in signal transduction and carcinogenesis. ongoing research,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7990661&form=6&db=m In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999261&form=6&db=m Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8180424&form=6&db=m Altered membrane lipid composition in a human meningosarcoma. causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8270608&form=6&db=m Stimulation of prostaglandin E2 production and induction of specific protein synthesis in rat peritoneal macrophages by a tumor promoter staurosporine. therapeutic application,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8304947&form=6&db=m Sphingolipids inhibit multistage carcinogenesis and protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8547831&form=6&db=m Noninvasive detection of putative biomarkers for colon cancer using fecal messenger RNA. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8625306&form=6&db=m Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8645426&form=6&db=m High-fat diet blocks the inhibition of skin carcinogenesis and reductions in protein kinase C by moderate energy restriction. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8646790&form=6&db=m Signal transduction mechanism in response to aflatoxin B1 exposure: protein kinase C activity. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698190&form=6&db=m Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8782428&form=6&db=m Promoting phorbol ester-TPA enhances migration of C3H 10T1/2 cells. The role of protein kinase C and its relation to carcinogenesis. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8917690&form=6&db=m Fumonisin B1 induces protein kinase C translocation via direct interaction with diacylglycerol binding site. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964400&form=6&db=m Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038375&form=6&db=m Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111205&form=6&db=m Changes in protein kinase C alpha, delta and in nuclear beta isoform expression in tumour and lung metastatic nodules induced by diethylnitrosamine in the rat. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167945&form=6&db=m Protein kinase C alpha and tumorigenesis of the endocrine gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187136&form=6&db=m Reexpression of the major protein kinase C substrate, SSeCKS, suppresses v-src-induced morphological transformation and tumorigenesis. therapeutic application,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9260587&form=6&db=m Regulation of p53 by protein kinase C during multi-stage carcinogenesis. causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9383464&form=6&db=m Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459180&form=6&db=m Modulation of aflatoxin B1 activated protein kinase C by phenolic compounds. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486854&form=6&db=m Transformation-sensitive changes in expression, localization, and phosphorylation of adducins in renal proximal tubule epithelial cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9495244&form=6&db=m Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498273&form=6&db=m Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9563643&form=6&db=m Differential expression of protein kinase C isoforms in diethylnitrosamine-initiated rat liver. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589428&form=6&db=m Dietary lipid varying in corn and coconut oil influences protein kinase C in phorbol ester-treated mouse skin. ongoing research,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9644192&form=6&db=m The cytochromes P450 and mechanisms of chemical carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9676858&form=6&db=m Disparity in expression of protein kinase C alpha in human glioma versus glioma-derived primary cell lines: therapeutic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9683604&form=6&db=m From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9757124&form=6&db=m Crystallographic characterization of Pap1-DNA complex. therapeutic application,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823005&form=6&db=m Timing of dietary fat exposure and mammary tumorigenesis: role of estrogen receptor and protein kinase C activity. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022132&form=6&db=m PKCdelta acts as a growth and tumor suppressor in rat colonic epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10320749&form=6&db=m Influence of ionizing radiation on induction of apoptotic cell death and cellular redistribution of protein kinase C isozymes in mouse epidermal cells differing in carcinogenesis stages. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10330400&form=6&db=m Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523713&form=6&db=m The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review). causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10529197&form=6&db=m Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597283&form=6&db=m Increased protein kinase C delta in mammary tumor cells: relationship to transformtion and metastatic progression. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10675484&form=6&db=m Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748087&form=6&db=m Direct interaction of all-trans-retinoic acid with protein kinase C (PKC). Implications for PKC signaling and cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10757128&form=6&db=m A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10786662&form=6&db=m Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice. causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854546&form=6&db=m Protein kinase C activity in human gastric carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854687&form=6&db=m Modification of tight junction function by protein kinase C isoforms. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10887491&form=6&db=m Protein kinase C isozymes and substrates in mammary carcinogenesis. causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10926556&form=6&db=m Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-alpha content. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245437&form=6&db=m Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11288038&form=6&db=m Effects of dietary restriction on appendicular bone in the SENCAR mouse. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375968&form=6&db=m Protein kinase C isozymes in colon carcinogenesis: guilt by omission. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384739&form=6&db=m Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis. ongoing research,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477572&form=6&db=m Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11894137&form=6&db=m Lack of protein kinase C (PKC)-beta and low PKC-alpha, -delta, -epsilon, and -zeta isozyme levels in proliferating human melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994357&form=6&db=m Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12058013&form=6&db=m Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068001&form=6&db=m Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12095674&form=6&db=m Genomic organization and chromosomal localization of the mouse protein kinase C alpha gene. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203364&form=6&db=m Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473186&form=6&db=m Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12480928&form=6&db=m Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507930&form=6&db=m Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12600262&form=6&db=m Molecular mechanisms of the cross-impact of pathological processes in combined diabetes and cancer. Research and clinical aspects. causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809676&form=6&db=m Genomic structure and promoter analysis of PKC-delta. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12840533&form=6&db=m Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models. ongoing research,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12917818&form=6&db=m Antisense strategies targeting protein kinase C: preclinical and clinical development. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939403&form=6&db=m Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14641818&form=6&db=m Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729403&form=6&db=m Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15024028&form=6&db=m Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15037605&form=6&db=m Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057036&form=6&db=m The role of protein kinase C-alpha (PKC-alpha) in melanoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15098066&form=6&db=m Protein kinase D and keratinocyte proliferation. causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15112056&form=6&db=m Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes. ongoing research,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159408&form=6&db=m Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15216909&form=6&db=m Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313921&form=6&db=m Antisense targeting protein kinase C alpha and beta1 inhibits gastric carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322124&form=6&db=m Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15335814&form=6&db=m Characterization of PKC2, a gene encoding a second protein kinase C isotype of Saccharomyces cerevisiae. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363561&form=6&db=m Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458367&form=6&db=m Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103087&form=6&db=m Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16106402&form=6&db=m Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-kappaB and AP-1 in human colon cancer cells. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16122920&form=6&db=m Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16197574&form=6&db=m Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204062&form=6&db=m Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424642&form=6&db=m The role of protein kinase C-alpha in hematologic malignancies. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16434969&form=6&db=m Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16628396&form=6&db=m A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16683077&form=6&db=m A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16683253&form=6&db=m Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. therapeutic application,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797377&form=6&db=m Protein kinase C-beta as a therapeutic target in breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849539&form=6&db=m Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940160&form=6&db=m Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145886&form=6&db=m Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17158769&form=6&db=m Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459358&form=6&db=m Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483345&form=6&db=m p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17542601&form=6&db=m Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616661&form=6&db=m Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17636410&form=6&db=m The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17922632&form=6&db=m The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942077&form=6&db=m Isoform-specific translocation of PKC isoforms in NIH3T3 cells by TPA. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17943721&form=6&db=m HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18037997&form=6&db=m PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339873&form=6&db=m Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18650932&form=6&db=m Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18706831&form=6&db=m Signalling adaptors used by Toll-like receptors: an update. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18755647&form=6&db=m [Protein kinases C: a new cytoplasmic target] causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794128&form=6&db=m Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955501&form=6&db=m Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147581&form=6&db=m Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19175182&form=6&db=m Immunochemical localization of protein kinase Calpha in the biopsies of human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208825&form=6&db=m Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). ongoing research,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221092&form=6&db=m Protein kinase Cbeta is an effective target for chemoprevention of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19228372&form=6&db=m Protein kinase C epsilon: an oncogene and emerging tumor biomarker. causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232344&form=6&db=m PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19290490&form=6&db=m Expression of P-aPKC-iota, E-cadherin, and beta-catenin related to invasion and metastasis in hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509063&form=6&db=m A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628766&form=6&db=m NF-kappaB regulates androgen receptor expression and prostate cancer growth. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672862&form=6&db=m Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19749780&form=6&db=m Protein kinase Calpha puts the hand cuffs on epidermal keratinocyte proliferation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19778415&form=6&db=m scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910471&form=6&db=m c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20010864&form=6&db=m Sun-sensitizing effects of PKCepsilon shine on multiple mouse strains. ongoing research,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20336469&form=6&db=m PKC inhibition increases gap junction intercellular communication and cell adhesion in human neuroblastoma. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21266973&form=6&db=m Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268127&form=6&db=m Upregulation of the EP1 receptor for prostaglandin E(2) promotes skin tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21335545&form=6&db=m Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544325&form=6&db=m Dexniguldipine hydrochloride inhibits growth of human pancreatic adenocarcinoma cells and expression of protein kinase C isoforms alpha and zeta. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552934&form=6&db=m Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556896&form=6&db=m Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895402&form=6&db=m Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905203&form=6&db=m Protein kinase C in Wnt signaling: Implications in cancer initiation and progression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22242955&form=6&db=m "Expression of protein kinase C isoforms in cancerous breast tissue and adjacent normal breast tissue". causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349825&form=6&db=m Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22359542&form=6&db=m Protein Kinase C Iota Regulates Pancreatic Acinar-to-Ductal Metaplasia. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22799301&form=6&db=m Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349696&form=6&db=m Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C. causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542175&form=6&db=m p120 catenin is a key effector of a Ras-PKC? oncogenic signaling axis. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23835532&form=6&db=m Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23962904&form=6&db=m Phase I dose escalation study of the PKC? inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24037523&form=6&db=m Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24254684&form=6&db=m Actions of a tumor-promoting phorbol ester in a cloned rat pituitary cell : Potential involvement of changes in Ca(2+) metabolism. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24511045&form=6&db=m The role of activation-induced cytidine deaminase expression in gastric adenocarcinoma. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24795864&form=6&db=m Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis. causal interaction,unassigned 3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25075050&form=6&db=m Expression of Stathmin1 in gastric adenocarcinoma. causal interaction,unassigned 2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25660024&form=6&db=m Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of ?-Catenin and Yap by PKC? unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26279297&form=6&db=m PKCiota promotes ovarian tumor progression through deregulation of cyclin E. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26466675&form=6&db=m Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26590425&form=6&db=m K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26792725&form=6&db=m PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling. causal interaction,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884861&form=6&db=m Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27424921&form=6&db=m Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481515&form=6&db=m PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28402859&form=6&db=m Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28571764&form=6&db=m Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048616&form=6&db=m The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29524560&form=6&db=m RAS-mediated oncogenic signaling pathways in human malignancies. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29588366&form=6&db=m The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29927112&form=6&db=m Generating Conformation-Specific Polyclonal and Monoclonal Anti-Protein Kinase C Antibodies and Anti-Active State Specific PKC Antibodies. causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29927433&form=6&db=m [The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors]. unassigned - 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31474570&form=6&db=m The Dual Roles of the Atypical Protein Kinase Cs in Cancer. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545907&form=6&db=m Extracellular pyruvate kinase M2 facilitates cell migration by upregulating claudin-1 expression in colon cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32994205&form=6&db=m PKC epsilon is required for KRAS-driven lung tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33146712&form=6&db=m Transcription factor Sp1 is upregulated by PKC? to drive the expression of YAP1 during pancreatic carcinogenesis. causal interaction,unassigned 1,0 2.7.11.13 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195807&form=6&db=m Prostasin regulates PD-L1 expression in human lung cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18719002&form=6&db=m Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309437&form=6&db=m Growth inhibition of transforming growth factor beta on human gastric carcinoma cells: receptor and postreceptor signaling. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309802&form=6&db=m Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma cell line. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329908&form=6&db=m Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1363517&form=6&db=m Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379589&form=6&db=m Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380512&form=6&db=m Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1637359&form=6&db=m Dual role for protein kinase C alpha as a regulator of ion secretion in the HT29cl.19A human colonic cell line. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1701695&form=6&db=m Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707036&form=6&db=m The effect of fetal calf serum on growth arrest caused by activators of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1727670&form=6&db=m Protein kinase C activity in human colonic adenoma and colorectal carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1807790&form=6&db=m Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1930266&form=6&db=m The role of protein kinase C and the phosphatidylinositol cycle in multidrug resistance in human ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1969850&form=6&db=m Phorbol esters enhance the cyclic GMP response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa). ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1970571&form=6&db=m Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1972016&form=6&db=m Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells. therapeutic application,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1988085&form=6&db=m Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2000029&form=6&db=m Protein phosphorylation substrates in normal and neoplastic squamous epithelia of the human upper aero-digestive tract. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161375&form=6&db=m Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163883&form=6&db=m Regulation of phosphoinositide hydrolysis induced by histamine and guanine nucleotides in human HeLa carcinoma cells. Calcium and pH dependence and inhibitory role of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165399&form=6&db=m Agonist-induced desensitization of cholinergically stimulated phosphoinositide breakdown is independent of endogenously activated protein kinase C in HT-29 human colon carcinoma cells. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2224065&form=6&db=m Protein kinase C and casein kinase II activities in two human colon carcinoma cell lines, HT-29 and CaCo-2: possible correlation with differentiation. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2231770&form=6&db=m Inhibition of invasion of invasive human bladder carcinoma cells by protein kinase C inhibitor staurosporine. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2317779&form=6&db=m Changes in diacylglycerol and membrane associated protein kinase C activity reflect the growth status of xenografted human mammary carcinoma treated with 8-Cl-cAMP. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2407226&form=6&db=m Induction of the expression of differentiation-related antigens on human colon carcinoma cells by stimulating protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2448028&form=6&db=m Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2465349&form=6&db=m Correlation between cell-cell contact formation and activation of protein kinase C in a human squamous cell carcinoma cell line. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2500127&form=6&db=m Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509226&form=6&db=m Involvement of protein kinase C in translocation of desmoplakins from cytosol to plasma membrane during desmosome formation in human squamous cell carcinoma cells grown in low to normal calcium concentration. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543674&form=6&db=m Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide. causal interaction,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2720677&form=6&db=m Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2793184&form=6&db=m Isolation of cDNAs encoding a substrate for protein kinase C: nucleotide sequence and chromosomal mapping of the gene for a human 80K protein. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2892695&form=6&db=m Negative regulation of atrial natriuretic factor receptor coupled membrane guanylate cyclase by phorbol ester. Potential protein kinase C regulation of cyclic GMP signal in isolated adrenocortical carcinoma cells of rat. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2910827&form=6&db=m Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3355171&form=6&db=m Involvement of protein kinase C in the transcriptional regulation of ornithine decarboxylase gene expression by 12-O-tetradecanoylphorbol-13-acetate in T24 human bladder carcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3358773&form=6&db=m The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3499860&form=6&db=m Phorbol ester and epidermal growth factor receptors in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3828992&form=6&db=m Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3937830&form=6&db=m Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7478922&form=6&db=m Chloride secretion induced by phorbol dibutyrate and forskolin in the human colonic carcinoma cell line HT-29Cl.19A is regulated by different mechanisms. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7518003&form=6&db=m 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7576113&form=6&db=m Identification of protein kinase C zeta isozyme in hamster pancreas and pancreatic carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7579698&form=6&db=m Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7635571&form=6&db=m Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7635577&form=6&db=m Pro-transforming growth factor-alpha processing in human colon carcinoma cells: role of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7640049&form=6&db=m Temozolomide reduces the metastatic potential of Lewis lung carcinoma (3LL) in mice: role of alpha-6 integrin phosphorylation. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651730&form=6&db=m The natural protein kinase C alpha mutant is present in human thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7703529&form=6&db=m Changes in protein kinase C subspecies protein expression and activity in a series of multidrug-resistant human KB carcinoma cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7756686&form=6&db=m Effects of protein kinase C inhibitor, staurosporine derivative CGP 41 251, on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines. diagnostic usage,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7763022&form=6&db=m Associated expression of protein kinase C with resistance to doxorubicin in human lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7790386&form=6&db=m Role of protein kinase C alpha in the induction of carcinoembryonic antigen by transforming growth factor beta 1. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7802695&form=6&db=m Effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on HSP70 and HSP28 gene expression and thermotolerance development in human colon carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7819134&form=6&db=m The enterocyte-like differentiation of the Caco-2 tumor cell line strongly correlates with responsiveness to cAMP and activation of kinase A pathway. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7911467&form=6&db=m Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7960600&form=6&db=m Different biological effects of the two protein kinase C activators bryostatin-1 and TPA on human carcinoma cell lines. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989129&form=6&db=m The protein kinase C inhibitor, CGP 41 251, reverses decreased daunomycin uptake in a human drug-resistant ovarian carcinoma cell line. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7991611&form=6&db=m Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999261&form=6&db=m Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8014008&form=6&db=m Involvement of protein kinase C and an elastase-like enzyme in the processing of transforming growth factor-alpha in human colon carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8018413&form=6&db=m H7, an inhibitor of protein kinase C, inhibits tumour cell division in mice bearing ascitic Ehrlich's carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8039135&form=6&db=m Gene therapy through signal transduction pathways and angiogenic growth factors as therapeutic targets in breast cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8062222&form=6&db=m Expression of protein kinase C isoforms in skin papilloma and carcinoma of mice. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8098660&form=6&db=m Involvement of protein kinase C in the regulation of glycolipid sulfotransferase activity levels in renal cell carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117276&form=6&db=m Potentiation of glucocorticoid-mediated induction of the mouse mammary tumor virus promoter in mammary carcinoma cells by activation of protein kinase C. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8130082&form=6&db=m Epidermal growth factor increases 32P incorporation into phosphatidylcholine and protein kinase C activity in colon carcinoma cell line (HT29). causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8162345&form=6&db=m Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188761&form=6&db=m Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245514&form=6&db=m Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8249174&form=6&db=m Genetic events responsible for colorectal tumorigenesis: achievements and challenges. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8272389&form=6&db=m Activation of ion transport by combined effects of ionomycin, forskolin and phorbol ester on cultured HT-29cl.19A human colonocytes. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8297717&form=6&db=m Enhancement of sensitivity to platinum(II)-containing drugs by 12-O-tetradecanoyl-phorbol-13-acetate in a human ovarian carcinoma cell line. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388319&form=6&db=m Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8498520&form=6&db=m Regulation of taurine transport in human colon carcinoma cell lines (HT-29 and Caco-2) by protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566337&form=6&db=m A role for protein kinase C in the multidrug resistance phenotype of human carcinoma KB cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8593248&form=6&db=m Phosphatidylcholine could be the source of 1,2-DAG which activates protein kinase C in EGF-stimulated colon carcinoma cells (HT29). ongoing research,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612685&form=6&db=m Downregulation of protein kinase C suppresses induction of apoptosis in human prostatic carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630022&form=6&db=m Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643303&form=6&db=m Epidermal growth factor regulates topoisomerase II activity and drug sensitivity in human KB cells. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698190&form=6&db=m Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8732668&form=6&db=m Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8754760&form=6&db=m Differential growth regulation by all-trans retinoic acid is determined by protein kinase C alpha in human pancreatic carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8758918&form=6&db=m Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8758935&form=6&db=m Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8764886&form=6&db=m Phenylamino-pyrimidine (PAP) derivatives: a new class of potent and selective inhibitors of protein kinase C (PKC). ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8822090&form=6&db=m Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847210&form=6&db=m Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8895200&form=6&db=m Reduced daunomycin accumulation in drug-sensitive and multidrug-resistant human carcinoma KB cells following phorbol ester treatment: a potential role for protein kinase C in reducing drug influx. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8915489&form=6&db=m Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930400&form=6&db=m Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8939883&form=6&db=m Novel form of p21(WAF1/CIP1/SDI1) protein in phorbol ester-induced G2/M arrest. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8977340&form=6&db=m Antiproliferative effects of interferon alpha on human pancreatic carcinoma cell lines are associated with differential regulation of protein kinase C isoenzymes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9019168&form=6&db=m Properties of classic protein kinase C in human small cell lung carcinoma NCI-H345 cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9125850&form=6&db=m [Growth suppression of squamous cell carcinoma cell lines by PKCs--possible application to gene therapy] ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167945&form=6&db=m Protein kinase C alpha and tumorigenesis of the endocrine gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9186373&form=6&db=m Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9203625&form=6&db=m Antisense oligonucleotides targeting human protein kinase C-alpha inhibit phorbol ester-induced reduction of bradykinin-evoked calcium mobilization in A549 cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9205496&form=6&db=m Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346879&form=6&db=m The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. diagnostic usage,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9414406&form=6&db=m Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9448746&form=6&db=m Activation of glomerular mesangial cells by hepatocyte growth factor through tyrosine kinase and protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9564886&form=6&db=m Protein kinase Calpha controls the adhesion but not the antiproliferative response of human colon carcinoma cells to transforming growth factor beta1: identification of two distinct branches of post-protein kinase Calpha adhesion signal pathway. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9604994&form=6&db=m The effect of protein kinase C inhibitors on invasion of human ovary cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9743176&form=6&db=m Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756852&form=6&db=m Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765311&form=6&db=m Protein kinase C-dependent in vivo phosphorylation of prourokinase leads to the formation of a receptor competitive antagonist. causal interaction,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9826753&form=6&db=m Cationic porphyrins: novel delivery vehicles for antisense oligodeoxynucleotides. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9844914&form=6&db=m The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9935190&form=6&db=m Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphology. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9935234&form=6&db=m Increased transforming growth factor-alpha levels in human colon carcinoma cell lines over-expressing protein kinase C. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051751&form=6&db=m The protein kinase C (PKC) substrate GAP-43 is already expressed in neural precursor cells, colocalizes with PKCeta and binds calmodulin. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10368655&form=6&db=m Local inflammation may influence oral tumor cell differentiation. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10388539&form=6&db=m Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10625392&form=6&db=m Intracellular mRNA cleavage induced through activation of RNase P by nuclease-resistant external guide sequences. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10638334&form=6&db=m Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10638963&form=6&db=m Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657658&form=6&db=m Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676642&form=6&db=m Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737390&form=6&db=m Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10792956&form=6&db=m Phorbol esters rapidly attenuate glutamine uptake and growth in human colon carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10850628&form=6&db=m Differentially expressed mRNAs in androgen-independent but not androgen-dependent Shionogi carcinoma. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854546&form=6&db=m Protein kinase C activity in human gastric carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078419&form=6&db=m Endothelin receptor blockade potentiates FasL-induced apoptosis in colon carcinoma cells via the protein kinase C-pathway. therapeutic application,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221859&form=6&db=m Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11410863&form=6&db=m Expression of protein kinase C beta1 confers resistance to TNFalpha- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11451996&form=6&db=m High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483411&form=6&db=m Protein kinase C signalling pathway is involved in the regulation of vascular endothelial growth factor expression in human bladder transitional carcinoma cells. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11554166&form=6&db=m Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11600145&form=6&db=m Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11641060&form=6&db=m Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11682458&form=6&db=m Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723237&form=6&db=m Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11747987&form=6&db=m Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11831973&form=6&db=m [The effect of protein kinase C on the invasive behavior of human salivary adenoid cystic carcinoma in vitro] ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11877440&form=6&db=m Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11914646&form=6&db=m Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994357&form=6&db=m Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203369&form=6&db=m Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12402307&form=6&db=m Toward a more complete recognition of immunoreactive antigens in squamous cell lung carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12415618&form=6&db=m Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotides. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,3 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12538458&form=6&db=m Weekly bryostatin-1 in metastatic renal cell carcinoma: a phase II study. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12539531&form=6&db=m [Expressions of five protein kinase C isoforms in salivary adenoid cystic carcinoma] causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12635142&form=6&db=m Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645342&form=6&db=m Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12652652&form=6&db=m Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12652654&form=6&db=m Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657722&form=6&db=m Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789153&form=6&db=m Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810623&form=6&db=m Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888898&form=6&db=m Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907651&form=6&db=m Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12908597&form=6&db=m Protein kinase C and cAMP mediated regulation of taurine transport in human colon carcinoma cell lines (HT-29 & Caco-2). ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941843&form=6&db=m Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14559850&form=6&db=m Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14570379&form=6&db=m Distinct effects of protein kinase C on the barrier function at different developmental stages. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604996&form=6&db=m Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607845&form=6&db=m Requirement of protein kinase C micro activation and calpain-mediated proteolysis for arachidonic acid-stimulated adhesion of MDA-MB-435 human mammary carcinoma cells to collagen type IV. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14666709&form=6&db=m Protein kinase C eta is associated with progression of renal cell carcinoma (RCC). causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716767&form=6&db=m A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719062&form=6&db=m Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009987&form=6&db=m [Cell membrane phospholipid variation and protein kinase C expression effects on hepatic metastasis of large intestinal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025956&form=6&db=m [Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159020&form=6&db=m Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161701&form=6&db=m Pak-1 expression increases with progression of colorectal carcinomas to metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15221993&form=6&db=m Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313909&form=6&db=m Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363561&form=6&db=m Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15382037&form=6&db=m Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling. causal interaction,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458367&form=6&db=m Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520180&form=6&db=m Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531633&form=6&db=m Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555220&form=6&db=m Expression levels of protein kinase C-alpha in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15559761&form=6&db=m PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632005&form=6&db=m Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15641106&form=6&db=m Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15922420&form=6&db=m Role of protein kinase C-alpha in superficial bladder carcinoma recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963340&form=6&db=m Involvement of protein kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16008942&form=6&db=m [The role of protein kinase C alpha in recurrence of superficial bladder carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158048&form=6&db=m The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16225760&form=6&db=m Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243773&form=6&db=m Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16332726&form=6&db=m Stimulation of CEACAM1 expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium ionophore A23187 in endometrial carcinoma cells. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374540&form=6&db=m Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424000&form=6&db=m Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16441551&form=6&db=m Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517978&form=6&db=m Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16598791&form=6&db=m Integrin signaling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16651413&form=6&db=m Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16683253&form=6&db=m Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. therapeutic application,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778206&form=6&db=m Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17018591&form=6&db=m Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283176&form=6&db=m Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17303575&form=6&db=m Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. therapeutic application,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369850&form=6&db=m aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17393422&form=6&db=m Interaction of MUC1 with beta-catenin modulates the Wnt target gene cyclinD1 in H. pylori-induced gastric cancer. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17535728&form=6&db=m Membrane transporters and signal transduction. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17535735&form=6&db=m Identification of protein kinase C as an intermediate in Na,K-ATPase Beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17542601&form=6&db=m Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545611&form=6&db=m Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583567&form=6&db=m Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17957529&form=6&db=m Impaired Gap Junction Formation and Intercellular Calcium Signaling in Urinary Bladder Cancer Cells can be Improved by Gö6976. causal interaction,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314869&form=6&db=m Overexpression of protein kinase Calpha mRNA may be an independent prognostic marker for gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317448&form=6&db=m Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19117988&form=6&db=m A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19171421&form=6&db=m Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19194472&form=6&db=m Protein Kinase Cvarepsilon Inhibits UVR-Induced Expression of FADD, an Adaptor Protein, Linked to both Fas- and TNFR1-Mediated Apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19199036&form=6&db=m Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19223491&form=6&db=m Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232344&form=6&db=m PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19360323&form=6&db=m Butyrate-induced alterations of phosphoinositide metabolism, protein kinase C activity and reduced CD44 variant expression in HT-29 colon cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19714296&form=6&db=m Gemcitabine plus enzastaurin or single-agent gemcitabine in locally advanced or metastatic pancreatic cancer: Results of a Phase II, randomized, noncomparative study. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19738452&form=6&db=m Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19924022&form=6&db=m PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025870&form=6&db=m Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093383&form=6&db=m Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093486&form=6&db=m Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20169155&form=6&db=m Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338221&form=6&db=m Reorganization of cytoskeletal proteins by Escherichia coli heat-stable enterotoxin (STa)-mediated signaling cascade. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20407013&form=6&db=m Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20494415&form=6&db=m Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501645&form=6&db=m Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731935&form=6&db=m [The variation of intracellular distribution and translocation of the protein kinase C alpha among human lung cancer cell line with different metastasis potential.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876745&form=6&db=m Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20967867&form=6&db=m Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21179694&form=6&db=m [Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells]. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340822&form=6&db=m Compartmentalized protein kinase C activation in ovarian carcinoma cells. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21400668&form=6&db=m DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21414654&form=6&db=m A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480396&form=6&db=m Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C ? with Stat3 involve integration with Erk1/2. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552934&form=6&db=m Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705328&form=6&db=m Dual Function of Protein Kinase C (PKC) in 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced Manganese Superoxide Dismutase (MnSOD) Expression: ACTIVATION OF CREB AND FOXO3a BY PKC-{alpha} PHOSPHORYLATION AND BY PKC-MEDIATED INACTIVATION OF Akt, RESPECTIVELY. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21712053&form=6&db=m Protein kinase C ? regulates nuclear pri-microRNA 15a release as part of endothelin signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955404&form=6&db=m The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21961726&form=6&db=m Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22384062&form=6&db=m Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22969158&form=6&db=m Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKC? Invasive Signaling Axis. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376641&form=6&db=m Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23446420&form=6&db=m GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23464396&form=6&db=m Resveratrol affects protein kinase C activity and promotes apoptosis in human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520519&form=6&db=m Protein kinase C delta negatively modulates canonical wnt pathway and cell proliferation in colon tumor cell lines. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23695799&form=6&db=m Modulation of Pancreatic Tumor Potential by Overexpression of Protein Kinase C ?1. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23738074&form=6&db=m Protein Kinase C ? , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750277&form=6&db=m Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26586792&form=6&db=m Genetic deletion of TNF? inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKC? transgenic mice via inhibition of cell survival signals. causal interaction,unassigned 2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27037060&form=6&db=m PKC? inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27351203&form=6&db=m miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway. unassigned - 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481515&form=6&db=m PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554045&form=6&db=m PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28564697&form=6&db=m Activation of Protein Kinase C ? in Merkel Cell Polyomavirus-Induced Merkel Cell Carcinoma. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396949&form=6&db=m Atypical Protein Kinase C ?/? Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11831973&form=6&db=m [The effect of protein kinase C on the invasive behavior of human salivary adenoid cystic carcinoma in vitro] ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12539531&form=6&db=m [Expressions of five protein kinase C isoforms in salivary adenoid cystic carcinoma] causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21400668&form=6&db=m DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.11.13 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27351203&form=6&db=m miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway. unassigned - 2.7.11.13 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245514&form=6&db=m Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9205496&form=6&db=m Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907651&form=6&db=m Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23446420&form=6&db=m GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. unassigned - 2.7.11.13 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645342&form=6&db=m Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15454252&form=6&db=m Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19924022&form=6&db=m PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 2.7.11.13 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24786829&form=6&db=m PKC?/? signaling promotes triple-negative breast cancer growth and metastasis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311643&form=6&db=m Enhancement of spermidine/spermine N1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1402129&form=6&db=m Effect of hyperthermia and protein kinase C inhibitors on DNA synthesis and cell proliferation on Ehrlich ascites tumour cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1959608&form=6&db=m Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8038218&form=6&db=m Activation of protein kinase C during cell volume regulation in Ehrlich mouse ascites tumor cells. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8492304&form=6&db=m Na+, K+, Cl- cotransport and its regulation in Ehrlich ascites tumor cells. Ca2+/calmodulin and protein kinase C dependent pathways. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8699481&form=6&db=m Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells. unassigned - 2.7.11.13 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2556264&form=6&db=m The SV40 TC-II(kappa B) and the related H-2Kb enhansons exhibit different cell type specific and inducible proto-enhancer activities, but the SV40 core sequence and the AP-2 binding site have no enhanson properties. therapeutic application,unassigned 2,0 2.7.11.13 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3458626&form=6&db=m Protein kinase C and phorbol ester receptor expression related to growth and differentiation of nullipotent and pluripotent embryonal carcinoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7513693&form=6&db=m A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9486851&form=6&db=m Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17959229&form=6&db=m Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.13 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672862&form=6&db=m Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317101&form=6&db=m Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2). ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1350054&form=6&db=m Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370614&form=6&db=m Divergent effects of phorbol esters and insulin on insulin-like growth factor binding protein-1 (IGFBP-1) production and mRNA in rat H4IIE hepatoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1577756&form=6&db=m Role of protein kinase C in insulin's regulation of c-fos transcription. therapeutic application,unassigned 1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1591275&form=6&db=m Glucocorticoid regulation of phospholipid turnover and protein kinase C activity in mouse hepatoma 22 cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1605850&form=6&db=m Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1637923&form=6&db=m [Regulation of the phospholipid turnover rate and protein kinase C activity as a necessary stage in the realization of the growth-inhibiting effect of dexamethasone on hepatoma 22 cells] ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655729&form=6&db=m Different induction of two plasminogen activator inhibitor 1 mRNA species by phorbol ester in human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656952&form=6&db=m Inhibition of erythropoietin production by phorbol ester is associated with down-regulation of protein kinase C-alpha isoenzyme in hepatoma cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1708698&form=6&db=m Vacuole formation and cytokeratin rearrangement of hepatoma cells induced by teleocidin are not associated with down-regulation of protein kinase C. unassigned - 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2015852&form=6&db=m Involvement of protein kinase C in the regulation of ornithine decarboxylase mRNA by phorbol esters in rat hepatoma cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174364&form=6&db=m Regulation of Ki-ras expression in Reuber H35 cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2197271&form=6&db=m Insulin activates the Raf-1 protein kinase. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3059980&form=6&db=m [Regulation of glucose metabolism by insulin: dual role of protein kinase C] ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3158389&form=6&db=m The influence of extracellular calcium on the distribution of protein kinase C in non-neoplastic and neoplastic rat liver cells. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3245094&form=6&db=m [Comparative study of protein kinase C in the normal rat liver and in Zajdela's hepatoma. I. Electrophoretic analysis] diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3280335&form=6&db=m Effect of protein kinase C activation and depletion on insulin stimulation of glycogen synthesis in cultured hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3289895&form=6&db=m Transcriptional regulation of a rat hepatoma gene by insulin and protein kinase-C. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3331712&form=6&db=m The inhibition of phosphoenolpyruvate carboxykinase (guanosine triphosphate) gene expression by insulin is not mediated by protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7475949&form=6&db=m Tyrosine kinase inhibitors potentiate the induction of low density lipoprotein receptor gene expression by hepatocyte growth factor. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7503734&form=6&db=m Differential expression of five protein kinase C isoenzymes in FAO and HepG2 hepatoma cell lines compared with normal rat hepatocytes. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7528138&form=6&db=m Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681664&form=6&db=m Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7789317&form=6&db=m Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells. unassigned - 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7811240&form=6&db=m Involvement of the alpha isoenzyme of protein kinase C in the growth inhibition induced by phorbol esters in MH1C1 hepatoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7827802&form=6&db=m Inhibitory effect of hepatocyte growth factor against FaO hepatocellular carcinoma cells may be associated with changes of intracellular signalling pathways mediated by protein kinase C. causal interaction,unassigned 1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7835279&form=6&db=m Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7988415&form=6&db=m Evidence for diverse roles of protein kinase-C in the inhibition of gene expression by insulin: the tyrosine aminotransferase, albumin, and phosphoenolpyruvate carboxykinase genes. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8052143&form=6&db=m Evidence for a role of protein kinase C in the activation of the pyruvate dehydrogenase complex by insulin in Zajdela hepatoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276122&form=6&db=m Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2. Role of protein kinase C. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395971&form=6&db=m Involvement of down-regulation-resistant protein kinase C in teleocidin inhibition of cell proliferation and calcium mobilization induced by epidermal growth factor and vasopressin in human hepatoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8402589&form=6&db=m Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8557761&form=6&db=m Interaction of insulin, glucocorticoids, and protein kinase C in the regulation of insulin-like growth factor-binding protein-1 production by H4IIE rat hepatoma cells. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615646&form=6&db=m Assessment of the metastatic ability of rat hepatoma cells in chick embryos by the polymerase-chain reaction. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630022&form=6&db=m Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663472&form=6&db=m Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. causal interaction,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8831721&form=6&db=m Identification of a protein kinase C (PKC) activator, daphnoretin, that suppresses hepatitis B virus gene expression in human hepatoma cells. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8917435&form=6&db=m Role of c-Jun and proximal phorbol 12-myristate-13-acetate-(PMA)-responsive elements in the regulation of basal and PMA-stimulated plasminogen-activator inhibitor-1 gene expression in HepG2. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973580&form=6&db=m Protein kinase C bound to the Golgi apparatus supports the formation of constitutive transport vesicles. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9128187&form=6&db=m Lead may affect glucocorticoid signal transduction in cultured hepatoma cells through inhibition of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9140111&form=6&db=m Inhibition by protein kinase C inhibitor of expression of leukocyte function-associated antigen-1 molecules in rat hepatoma AH66F cells. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214694&form=6&db=m Leukocyte function-associated antigen 1-dependent adhesion of rat hepatoma AH66F cells and inhibition by protein kinase C inhibitors. unassigned - 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514088&form=6&db=m Inhibition of the membrane translocation and activation of protein kinase C, and potentiation of doxorubicin-induced apoptosis of hepatocellular carcinoma cells by tamoxifen. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639562&form=6&db=m Differential effects of phorbol ester on growth and protein kinase C isoenzyme regulation in human hepatoma Hep3B cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9704573&form=6&db=m Translocation of PKC delta by insulin in a rat hepatoma cell line. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9706147&form=6&db=m Protein kinase C regulates nutrient uptake and growth in hepatoma cells. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9718078&form=6&db=m Activation of protein kinase C in human hepatocellular carcinoma (HEP3B) cells increases erythropoietin production. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755245&form=6&db=m Activation of protein kinase Calpha couples cell volume to membrane Cl- permeability in HTC hepatoma and Mz-ChA-1 cholangiocarcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10354503&form=6&db=m Protein kinase C alpha protein expression is necessary for sustained erythropoietin production in human hepatocellular carcinoma (Hep3B) cells exposed to hypoxia. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10497883&form=6&db=m Expression of calcium-binding protein regucalcin mRNA in the cloned rat hepatoma cells (H4-II-E) is stimulated through Ca2+ signaling factors: involvement of protein kinase C. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090966&form=6&db=m Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11101004&form=6&db=m The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11149024&form=6&db=m Protein kinase C inhibitor, H-7 suppresses the growth activity of hepatoma-derived growth factor. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170310&form=6&db=m Down-regulation of particulate protein kinase Cepsilon and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287749&form=6&db=m Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11329613&form=6&db=m An insight into the mechanism of cytotoxicity of ricin to hepatoma cell: roles of Bcl-2 family proteins, caspases, Ca(2+)-dependent proteases and protein kinase C. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11424083&form=6&db=m beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells. therapeutic application,unassigned 1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880239&form=6&db=m Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11997513&form=6&db=m Critical role of diacylglycerol- and phospholipid-regulated protein kinase C epsilon in induction of low-density lipoprotein receptor transcription in response to depletion of cholesterol. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12059989&form=6&db=m Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388769&form=6&db=m Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532446&form=6&db=m Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12639703&form=6&db=m Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740906&form=6&db=m Involvement of PKC betaII in anti-proliferating action of a new antitumor compound gnidimacrin. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298768&form=6&db=m Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15730925&form=6&db=m Effects of antisense oligonucleotides of PKC-alpha on proliferation and apoptosis of HepG2 in vitro. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15917995&form=6&db=m Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15980869&form=6&db=m The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16169661&form=6&db=m Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16304840&form=6&db=m Expression of protein kinase C alpha in biopsies and surgical specimens of human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16545776&form=6&db=m PKCtheta is a key player in the development of insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16601764&form=6&db=m Changes in mRNA levels of intracellular fatty acid metabolism regulators in human hepatoma HepG2 cells following their treatment with non-esterified fatty acids and dehydroepiandrosterone. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050668&form=6&db=m Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459358&form=6&db=m Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483345&form=6&db=m p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17486587&form=6&db=m Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17593797&form=6&db=m Suppression of tumorigenicity of human hepatocellular carcinoma cells by antisense oligonucleotide MZF-1. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17673262&form=6&db=m Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950002&form=6&db=m Antisense oligonucleotide Elk-1 suppresses the tumorigenicity of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167130&form=6&db=m Involvement of protein kinase C beta-extracellular signal-regulating kinase 1/2/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281497&form=6&db=m FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19112601&form=6&db=m Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19175182&form=6&db=m Immunochemical localization of protein kinase Calpha in the biopsies of human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19949911&form=6&db=m Expression of Protein Kinase C Family in Human Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20001341&form=6&db=m Analysing the expression of protein kinase C eta in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032465&form=6&db=m Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition. therapeutic application,unassigned 1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20138242&form=6&db=m Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20444294&form=6&db=m PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556896&form=6&db=m Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21562647&form=6&db=m Anti-invasive activity of ?-tocopherol against hepatoma cells in culture via protein kinase C inhibition. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566973&form=6&db=m Doxorubicin enhances transient expression of p-glycoprotein and modulates activity and isoform expression of protein-kinase-C in ah66 rat hepatoma-cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21607402&form=6&db=m Characteristic changes in protein-kinase-C activity and isoforms in ah66 cells during the acquisition of multidrug-resistant phenotype. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21607476&form=6&db=m Differential phorbol ester growth modulation and protein-kinase-C isoenzyme expression in rat hepatoma-cells vs non neoplastic rat hepatocytes. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21793318&form=6&db=m Protein kinase C alpha location and the expression of phospho-MEK and MDR1 in hepatitis virus-related hepatocellular carcinoma biopsies. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21842414&form=6&db=m Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21935400&form=6&db=m Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma. diagnostic usage,unassigned 3,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22242952&form=6&db=m "Expression of Protein Kinase C?and the MZF-1 and Elk-1 Transcription Factors in Human Breast Cancer Cells". unassigned - 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22559731&form=6&db=m Expression of protein kinase C? and the MZF-1 and elk-1 transcription factors in human bladder transitional cell carcinoma cells. unassigned - 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23107691&form=6&db=m (-)-Epigallocatechin-3-gallate stimulates both AMP-activated protein kinase and nuclear factor-kappa B signaling pathways. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26010542&form=6&db=m MZF-1/Elk-1 Complex Binds to Protein Kinase C? Promoter and Is Involved in Hepatocellular Carcinoma. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26245668&form=6&db=m Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26311153&form=6&db=m Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30906629&form=6&db=m E2F1 transactivates IQGAP3 and promotes proliferation of hepatocellular carcinoma cells through IQGAP3-mediated PKC-alpha activation. unassigned - 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30907226&form=6&db=m Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. unassigned - 2.7.11.13 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33307168&form=6&db=m PKC? mediates mitochondrial ROS generation and oxidation of HSP60 to relieve RKIP inhibition on MAPK pathway for HCC progression. causal interaction,unassigned 1,0 2.7.11.13 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15454252&form=6&db=m Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinoma, Islet Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161375&form=6&db=m Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2500127&form=6&db=m Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543674&form=6&db=m Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide. causal interaction,unassigned 3,0 2.7.11.13 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7640049&form=6&db=m Temozolomide reduces the metastatic potential of Lewis lung carcinoma (3LL) in mice: role of alpha-6 integrin phosphorylation. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388319&form=6&db=m Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6. unassigned - 2.7.11.13 Carcinoma, Merkel Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28564697&form=6&db=m Activation of Protein Kinase C ? in Merkel Cell Polyomavirus-Induced Merkel Cell Carcinoma. ongoing research,unassigned 1,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8822090&form=6&db=m Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121973&form=6&db=m Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591726&form=6&db=m Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025956&form=6&db=m [Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15447994&form=6&db=m A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15696546&form=6&db=m Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705582&form=6&db=m Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. causal interaction,unassigned 1,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15994303&form=6&db=m Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204062&form=6&db=m Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507327&form=6&db=m Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16861740&form=6&db=m Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525161&form=6&db=m Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation. causal interaction,unassigned 3,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616661&form=6&db=m Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18158564&form=6&db=m Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18162471&form=6&db=m S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. unassigned - 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19333010&form=6&db=m Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20436341&form=6&db=m Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20646461&form=6&db=m [Effects of a protein kinase C inhibitor combined with cisplatin on non-small cell lung cancer] diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673527&form=6&db=m [The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712961&form=6&db=m [Protein kinase C inhibitor and treatment of non-small cell lung cancer.] therapeutic application,unassigned 4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21211186&form=6&db=m [A study on the relationship between the expression of protein kinase C ?II and apoptosis in patients with non-small cell lung cancer.] diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219643&form=6&db=m Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22384062&form=6&db=m Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24461294&form=6&db=m Inhibition of protein kinase C ?/?II and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636699&form=6&db=m The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25351171&form=6&db=m The protein kinase C (PKC) inhibitors combined with chemotherapy in the treatment of advanced non-small cell lung cancer: meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26918447&form=6&db=m PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648127&form=6&db=m Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer. therapeutic application,unassigned 3,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648598&form=6&db=m PKC? regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells. unassigned - 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32015677&form=6&db=m Ophiopogon Saponin C1 Inhibits Lung Tumors by Stabilizing Endothelium Permeability via Inhibition of PKC?. causal interaction,unassigned 1,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324562&form=6&db=m Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients. causal interaction,diagnostic usage,unassigned 2,2,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073823&form=6&db=m Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34472101&form=6&db=m l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. unassigned - 2.7.11.13 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311494&form=6&db=m Follicle-stimulating hormone promotes the growth of human epithelial ovarian cancer cells through the protein kinase C-mediated system. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16116079&form=6&db=m Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Carcinoma, Pancreatic Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161375&form=6&db=m Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma, Pancreatic Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8915489&form=6&db=m Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1807790&form=6&db=m Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651730&form=6&db=m The natural protein kinase C alpha mutant is present in human thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.11.13 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994357&form=6&db=m Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1363517&form=6&db=m Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3678377&form=6&db=m Inhibitory effects of tetradecanoylphorbol acetate and diacylglycerol on erythropoietin production in human renal carcinoma cell cultures. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8098660&form=6&db=m Involvement of protein kinase C in the regulation of glycolipid sulfotransferase activity levels in renal cell carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8103344&form=6&db=m Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627883&form=6&db=m Tumor necrosis factor mediates apoptosis via Ca++/Mg++ dependent endonuclease with protein kinase C as a possible mechanism for cytokine resistance in human renal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346879&form=6&db=m The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. diagnostic usage,unassigned 3,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756852&form=6&db=m Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737390&form=6&db=m Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175550&form=6&db=m The serine proteinase thrombin promotes migration of human renal carcinoma cells by a PKA-dependent mechanism. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12538458&form=6&db=m Weekly bryostatin-1 in metastatic renal cell carcinoma: a phase II study. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14666709&form=6&db=m Protein kinase C eta is associated with progression of renal cell carcinoma (RCC). causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15221993&form=6&db=m Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16750009&form=6&db=m [Mechanism of reversal of multidrug resistance in human renal carcinoma cells by protein kinase C inhibitor] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19171421&form=6&db=m Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20494415&form=6&db=m Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955404&form=6&db=m The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27037060&form=6&db=m PKC? inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1545811&form=6&db=m The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1607773&form=6&db=m [The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)] ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1701695&form=6&db=m Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1880999&form=6&db=m Inhibitory regulation of serum factor(s)-caused ornithine decarboxylase induction by the protein kinase C system in A431 human epidermoid carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1986216&form=6&db=m Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2000029&form=6&db=m Protein phosphorylation substrates in normal and neoplastic squamous epithelia of the human upper aero-digestive tract. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2318819&form=6&db=m A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2443372&form=6&db=m Phorbol ester binding and protein kinase C activity in normal and transformed human keratinocytes. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2448028&form=6&db=m Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2465349&form=6&db=m Correlation between cell-cell contact formation and activation of protein kinase C in a human squamous cell carcinoma cell line. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509226&form=6&db=m Involvement of protein kinase C in translocation of desmoplakins from cytosol to plasma membrane during desmosome formation in human squamous cell carcinoma cells grown in low to normal calcium concentration. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3595874&form=6&db=m Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7506638&form=6&db=m Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8162345&form=6&db=m Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245514&form=6&db=m Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8546671&form=6&db=m Dual bradykinin B2 receptor signalling in A431 human epidermoid carcinoma cells: activation of protein kinase C is counteracted by a GS-mediated stimulation of the cyclic AMP pathway. unassigned - 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643303&form=6&db=m Epidermal growth factor regulates topoisomerase II activity and drug sensitivity in human KB cells. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8665482&form=6&db=m Interphase and M-phase oral KB carcinoma cells are targetted in staurosporine-induced apoptosis. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702931&form=6&db=m Protein kinase C deficiency blocks recovery from agonist-induced desensitization. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8822090&form=6&db=m Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847210&form=6&db=m Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9205496&form=6&db=m Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10638334&form=6&db=m Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221859&form=6&db=m Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. ongoing research,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11641060&form=6&db=m Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line. ongoing research,unassigned 2,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11914646&form=6&db=m Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12652652&form=6&db=m Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810623&form=6&db=m Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14559850&form=6&db=m Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458367&form=6&db=m Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520180&form=6&db=m Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. causal interaction,unassigned 4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555220&form=6&db=m Expression levels of protein kinase C-alpha in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632005&form=6&db=m Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15641106&form=6&db=m Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158048&form=6&db=m The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16225760&form=6&db=m Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243773&form=6&db=m Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424000&form=6&db=m Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16683253&form=6&db=m Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. therapeutic application,unassigned 1,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778206&form=6&db=m Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17018591&form=6&db=m Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283176&form=6&db=m Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583567&form=6&db=m Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer. unassigned - 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19117988&form=6&db=m A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19194472&form=6&db=m Protein Kinase Cvarepsilon Inhibits UVR-Induced Expression of FADD, an Adaptor Protein, Linked to both Fas- and TNFR1-Mediated Apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093486&form=6&db=m Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876745&form=6&db=m Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20967867&form=6&db=m Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21179694&form=6&db=m [Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells]. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480396&form=6&db=m Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C ? with Stat3 involve integration with Erk1/2. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23738074&form=6&db=m Protein Kinase C ? , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750277&form=6&db=m Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26586792&form=6&db=m Genetic deletion of TNF? inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKC? transgenic mice via inhibition of cell survival signals. causal interaction,unassigned 2,0 2.7.11.13 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11554166&form=6&db=m Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517978&form=6&db=m Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.7.11.13 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379995&form=6&db=m Protein-kinase-C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization. ongoing research,unassigned 2,0 2.7.11.13 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390801&form=6&db=m Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621230&form=6&db=m Inhibition of protein kinase C-dependent protein phosphorylation correlates with increased polarity and locomotion in Walker 256 carcinosarcoma cells. ongoing research,unassigned 4,0 2.7.11.13 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188728&form=6&db=m Role of protein kinase C isoforms in locomotion of Walker 256 carcinosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.13 Cardiac Output, Low http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336262&form=6&db=m Rationale, design and baseline characteristics of the PRO-TECT II study: PROpofol CardioproTECTion for Type II diabetics A randomized, controlled trial of high-dose propofol versus isoflurane preconditioning in patients undergoing on-pump coronary artery bypass graft surgery. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280532&form=6&db=m Changes in ventricular 1,2-diacylglycerol content in rats following monocrotaline treatment. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1702436&form=6&db=m Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1721095&form=6&db=m Mechanisms of cardiac hypertrophy and injury--possible role of protein kinase C activation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1835575&form=6&db=m Increased 19 kDa protein phosphorylation and protein kinase C activity in pressure-overload cardiac hypertrophy. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2146417&form=6&db=m Molecular mechanism of cardiac hypertrophy. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2177334&form=6&db=m Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7544686&form=6&db=m Triiodothyronine decreases the accumulation of 1,2-diacylglycerol in rat hearts. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7769485&form=6&db=m Involvement of the renin-angiotensin system in the development of left ventricular hypertrophy and dysfunction. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7884580&form=6&db=m Involvement of the renin-angiotensin system in the development of left ventricular hypertrophy and dysfunction. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7923639&form=6&db=m Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978332&form=6&db=m Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9405162&form=6&db=m Phosphatidic acid: a potential signal transducer for cardiac hypertrophy. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9705309&form=6&db=m The Raf-MEK-ERK cascade represents a common pathway for alteration of intracellular calcium by Ras and protein kinase C in cardiac myocytes. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9713323&form=6&db=m Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: effects of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat). causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600849&form=6&db=m PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864911&form=6&db=m Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016940&form=6&db=m Calcineurin blockade prevents cardiac mitogen-activated protein kinase activation and hypertrophy in renovascular hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11043608&form=6&db=m Decreased protein kinase C-epsilon expression in hypertrophied cardiac ventricles induced by triiodothyronine treatment in the rat. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11136699&form=6&db=m A Ca(2+)-dependent transgenic model of cardiac hypertrophy: A role for protein kinase Calpha. ongoing research,unassigned 2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179034&form=6&db=m PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression. causal interaction,unassigned 1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324523&form=6&db=m [The role of G protein, protein kinase C and Na(+)-H+ exchanger in endothelin-1-induced cardiomyocyte hypertrophic responses] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11330879&form=6&db=m Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553773&form=6&db=m Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11709417&form=6&db=m Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12392998&form=6&db=m Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504823&form=6&db=m Protein kinase C betaII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566467&form=6&db=m Increased translocation of cardiac protein kinase C beta2 accompanies mild cardiac hypertrophy in rats fed saturated fat. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12775975&form=6&db=m Regulation of protein kinase C isozyme and calcineurin expression in isoproterenol induced cardiac hypertrophy. causal interaction,unassigned 1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12808488&form=6&db=m Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. therapeutic application,unassigned 1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887134&form=6&db=m Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575310&form=6&db=m Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605019&form=6&db=m Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760444&form=6&db=m Potential role of lysophosphatidic acid in hypertension and atherosclerosis. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14764070&form=6&db=m Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15030426&form=6&db=m Activation of the Ca(2+)-activated nonselective cation channel by diacylglycerol analogues in rat cardiomyocytes. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167265&form=6&db=m Re: Regulation of protein kinase C isozyme and calcineurin expression in isoproterenol-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316932&form=6&db=m PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes. causal interaction,unassigned 2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15532718&form=6&db=m Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15557343&form=6&db=m Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15652511&form=6&db=m PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15761199&form=6&db=m Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15792354&form=6&db=m Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838320&form=6&db=m Activation of Peroxisome Proliferator-activated Receptor-alpha Decreases Endothelin-1-induced p38 Mitogen-activated Protein Kinase Activation in Cardiomyocytes. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899894&form=6&db=m Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930726&form=6&db=m Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963478&form=6&db=m Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency. causal interaction,unassigned 1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15988127&form=6&db=m Upregulation of phospholipase d expression and activation in ventricular pressure-overload hypertrophy. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16155104&form=6&db=m Nuclear localization of protein kinase C-alpha induces thyroid hormone receptor-alpha1 expression in the cardiomyocyte. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16530186&form=6&db=m Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16680066&form=6&db=m Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809552&form=6&db=m PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900949&form=6&db=m Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload. ongoing research,unassigned 1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949602&form=6&db=m Into the heart: The emerging role of the ubiquitin-proteasome system. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039281&form=6&db=m Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17251681&form=6&db=m Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261657&form=6&db=m Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. therapeutic application,unassigned 1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18219172&form=6&db=m Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18283710&form=6&db=m Multiple signaling pathways coordinately mediate reactive oxygen species dependent cardiomyocyte hypertrophy. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18425306&form=6&db=m [Protein kinase C regulates unloading contraction of cardiomyocytes in hypertrophic heart of spontaneously hypertensive rat.] causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18487437&form=6&db=m Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18656339&form=6&db=m Alcohol-free red wine inhibits isoproterenol-induced cardiac remodeling in rats by the regulation of Akt1 and protein kinase C alpha/beta II. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18662671&form=6&db=m ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19122165&form=6&db=m Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. causal interaction,unassigned 3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19395857&form=6&db=m Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. causal interaction,diagnostic usage,unassigned 1,2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19565009&form=6&db=m Docosahexaenoic acid inhibits protein kinase C translocation/activation and cardiac hypertrophy in rat cardiomyocytes. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19884565&form=6&db=m Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19995357&form=6&db=m Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131481&form=6&db=m Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes. causal interaction,unassigned 2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21726532&form=6&db=m A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23105625&form=6&db=m Prevention of isoproterenol-induced cardiac hypertrophy by eugenol, an antioxidant. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23795914&form=6&db=m Protein kinase C inhibitors: a patent review (2008 - 2009). causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24911080&form=6&db=m Beneficial role of tamoxifen in experimentally induced cardiac hypertrophy. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25116170&form=6&db=m Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. ongoing research,unassigned 2,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25489662&form=6&db=m Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26170457&form=6&db=m Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase C? in Cardiomyocytes. unassigned - 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713345&form=6&db=m Protein Kinases as Drug Development Targets for Heart Disease Therapy. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383124&form=6&db=m Genetic association between 1425G/A SNP in PRKCH and hypertrophic cardiomyopathy in a Chinese population. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651825&form=6&db=m Carvedilol alleviates diabetic cardiomyopathy in diabetic rats. causal interaction,unassigned 4,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30739223&form=6&db=m Phospho-substrate profiling of Epac-dependent protein kinase C activity. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33584253&form=6&db=m Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. causal interaction,unassigned 4,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3044883&form=6&db=m Alteration of 1,2-diacylglycerol content in myocardium from diabetic rats. causal interaction,unassigned 4,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9045700&form=6&db=m Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. I. Regulation of prodynorphin gene expression by nuclear protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256480&form=6&db=m Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458880&form=6&db=m Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. causal interaction,unassigned 3,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375719&form=6&db=m Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy. causal interaction,unassigned 3,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12193103&form=6&db=m Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy. ongoing research,unassigned 4,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196463&form=6&db=m Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12386152&form=6&db=m Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12441406&form=6&db=m Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16880328&form=6&db=m Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17250813&form=6&db=m N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. unassigned - 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19261738&form=6&db=m Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy. causal interaction,unassigned 2,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709863&form=6&db=m Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G{alpha}q protein-induced cardiomyopathy. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21303826&form=6&db=m Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. unassigned - 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22829732&form=6&db=m Designing of Protein Kinase C ?-II Inhibitors against Diabetic complications: Structure Based Drug Design, Induced Fit docking and analysis of active site conformational changes. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24050690&form=6&db=m Scaffold Hopping for Identification of Novel PKC?II Inhibitors Based on Ligand and Structural Approaches, Virtual Screening and Molecular Dynamics Study. unassigned - 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27989687&form=6&db=m Role of protein kinase C in metabolic regulation of the cardiac Na ongoing research,unassigned 1,0 2.7.11.13 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31315456&form=6&db=m Disruption of Ca2+i Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice. unassigned - 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899155&form=6&db=m Epsilon protein kinase C in pathological myocardial hypertrophy. Analysis by combined transgenic expression of translocation modifiers and Galphaq. causal interaction,unassigned 2,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14660611&form=6&db=m A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951344&form=6&db=m Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17503784&form=6&db=m PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594058&form=6&db=m Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921332&form=6&db=m Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17965277&form=6&db=m Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24670355&form=6&db=m Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins. ongoing research,unassigned 3,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27001966&form=6&db=m Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by ?- and ?-Myosin Heavy Chain Isoforms. ongoing research,unassigned 2,0 2.7.11.13 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27411801&form=6&db=m Interplay between the effects of a Protein Kinase C phosphomimic (T204E) and a dilated cardiomyopathy mutation (K211? or R206W) in rat cardiac troponin T blunts the magnitude of muscle length-mediated crossbridge recruitment against the ?-myosin heavy chain background. unassigned - 2.7.11.13 Cardiomyopathy, Hypertrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794893&form=6&db=m Cyclic AMP-dependent phosphodiesterase isozyme-specific potentiation by protein kinase C in hypertrophic cardiomyopathic hamster hearts. unassigned - 2.7.11.13 Cardiomyopathy, Hypertrophic, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14661957&form=6&db=m Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C. unassigned - 2.7.11.13 Cardiomyopathy, Restrictive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605019&form=6&db=m Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. causal interaction,unassigned 3,0 2.7.11.13 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16529545&form=6&db=m Cardiotoxicity of 5-Fluorouracil. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17519115&form=6&db=m Anionic currents in hypoxia-mediated cardiac toxicity: a computer study. unassigned - 2.7.11.13 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17535753&form=6&db=m Role of free radicals and antioxidants in health and disease. unassigned - 2.7.11.13 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28811127&form=6&db=m Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173149&form=6&db=m The central role of protein kinase C epsilon in cyanide cardiotoxicity and its treatment. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Cardiovascular Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19587355&form=6&db=m Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336880&form=6&db=m Vitamin E and vascular homeostasis: implications for atherosclerosis. causal interaction,unassigned 2,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882599&form=6&db=m Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. causal interaction,unassigned 3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12623995&form=6&db=m Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha. causal interaction,unassigned 4,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12699348&form=6&db=m Inwardly rectifying potassium channels in the regulation of vascular tone. causal interaction,unassigned 3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576967&form=6&db=m [Effects of calcium channel blockers in atherosclerosis and cardiovascular event and oxidative vascular damage] causal interaction,unassigned 4,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15811423&form=6&db=m Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardium. ongoing research,unassigned 2,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963387&form=6&db=m Alcohol and the cardiovascular system research challenges and opportunities. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16469861&form=6&db=m Physiological role of ROCKs in the cardiovascular system. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16781385&form=6&db=m Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956264&form=6&db=m Isoform-specific functions of protein kinase C: the platelet paradigm. unassigned - 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18180404&form=6&db=m Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II. causal interaction,unassigned 3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977358&form=6&db=m Protein kinase C mediated inhibition of endothelial L-arginine transport is mediated by MARCKS protein. ongoing research,unassigned 3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20678065&form=6&db=m Protein Kinase C - Possible Therapeutic Target to Treat Cardiovascular Diseases. therapeutic application,unassigned 4,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21232259&form=6&db=m Diversity of the protein kinase C gene family Implications for cardiovascular disease. causal interaction,unassigned 3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21497405&form=6&db=m Role of rho kinase in the functional and dysfunctional tonic smooth muscles. ongoing research,unassigned 2,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21876792&form=6&db=m Protein kinase C and toll-like receptor signaling. causal interaction,unassigned 3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22020176&form=6&db=m Ritonavir stimulates foam cell formation by activating PKC. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23606925&form=6&db=m Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24286628&form=6&db=m Detrimental effects of acute hyperglycaemia on the rat heart. unassigned - 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24861944&form=6&db=m Mitochondrial APE1/Ref-1 suppressed protein kinase C-induced mitochondrial dysfunction in mouse endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27916650&form=6&db=m Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 2.7.11.13 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25966946&form=6&db=m CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8319496&form=6&db=m Protein kinase C in galactosemic and tolrestat-treated lens epithelial cells. ongoing research,unassigned 3,0 2.7.11.13 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14562163&form=6&db=m Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16254550&form=6&db=m Expression of superoxide dismutase in whole lens prevents cataract formation. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050852&form=6&db=m PKCgamma knockout mouse lenses are more susceptible to oxidative stress damage. unassigned - 2.7.11.13 Cell Transformation, Neoplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1638537&form=6&db=m Expression of platelet-derived growth factor-independent phenotypes in BALB/c 3T3 cell variant with high susceptibility to chemically or physically induced neoplastic cell transformation: dissociation from activation of protein kinase C. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20014494&form=6&db=m [PICK1 is associated with central nervous system diseases] causal interaction,unassigned 4,0 2.7.11.13 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370642&form=6&db=m Comprehensive Account on the Synthesis of (-)-Balanol and its Analogues. causal interaction,unassigned 3,0 2.7.11.13 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313841&form=6&db=m Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15642736&form=6&db=m Oxidative activation of protein kinase Cgamma through the C1 domain. Effects on gap junctions. unassigned - 2.7.11.13 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16189624&form=6&db=m A novel H101Q mutation causes PKCgamma loss in spinocerebellar ataxia type 14. causal interaction,unassigned 3,0 2.7.11.13 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16547918&form=6&db=m Novel PRKCG/SCA14 mutation in a Dutch spinocerebellar ataxia family: expanding the phenotype. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29432535&form=6&db=m Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia. causal interaction,unassigned 2,0 2.7.11.13 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21172324&form=6&db=m The action of thrombin in intracerebral hemorrhage induced brain damage is mediated via PKC?/PKC? signaling. ongoing research,unassigned 2,0 2.7.11.13 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22808203&form=6&db=m The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16406313&form=6&db=m Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164711&form=6&db=m Association between PRKCH gene polymorphisms and subcortical silent brain infarction. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21756056&form=6&db=m Contribution of 1425G/A Polymorphism in Protein Kinase C-Eta (PRKCH) Gene and Brain White Matter Lesions to the Risk of Sudden Sensorineural Hearing Loss in a Japanese Nested Case-Control Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.7.11.13 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23793170&form=6&db=m Functional recovery and alterations in the expression and localization of protein kinase C following voluntary exercise in rat with cerebral infarction. ongoing research,unassigned 2,0 2.7.11.13 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25299527&form=6&db=m Protein kinase C activator, bryostatin-1, promotes exercise-dependent functional recovery in rats with cerebral infarction. unassigned - 2.7.11.13 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237974&form=6&db=m [Effect of Electroacupuncture at "Shuigou" (GV 26) on Immunoactivity and Content of Protein Kinase C in the Middle Cerebral Artery in Acute Cerebral Infarction Rats]. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26644690&form=6&db=m Protection mechanism of early hyperbaric oxygen therapy in rats with permanent cerebral ischemia. causal interaction,unassigned 1,0 2.7.11.13 Cerebral Small Vessel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28822176&form=6&db=m [Cerebral microangiopathy of diabetes]. causal interaction,unassigned 4,0 2.7.11.13 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895402&form=6&db=m Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Chediak-Higashi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2230592&form=6&db=m Thiol proteinase inhibitors reverse the increased protein kinase C down-regulation and concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mouse. causal interaction,unassigned 2,0 2.7.11.13 Chediak-Higashi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8929738&form=6&db=m Chediak-Higashi syndrome natural killer cells: a protein kinase C defective activation/regulation defect? unassigned - 2.7.11.13 Chediak-Higashi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10811017&form=6&db=m Abnormal down-regulation of PKC is responsible for giant granule formation in fibroblasts from CHS (beige) mice--a thiol proteinase inhibitor, E-64-d, prevents giant granule formation in beige fibroblasts. causal interaction,unassigned 3,0 2.7.11.13 Chediak-Higashi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11529921&form=6&db=m A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak-Higashi syndrome by reversing the down-regulated protein kinase C activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.11.13 Chediak-Higashi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17499200&form=6&db=m Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.7.11.13 Chediak-Higashi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19185618&form=6&db=m Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Chediak-Higashi Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830864&form=6&db=m Enhanced diacylglycerol production by phospholipase D activation is responsible for abnormal increase in concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mice. causal interaction,unassigned 4,0 2.7.11.13 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755245&form=6&db=m Activation of protein kinase Calpha couples cell volume to membrane Cl- permeability in HTC hepatoma and Mz-ChA-1 cholangiocarcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11281558&form=6&db=m Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha. therapeutic application,unassigned 1,0 2.7.11.13 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14701718&form=6&db=m Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. unassigned - 2.7.11.13 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825989&form=6&db=m H3 Histamine Receptor-Mediated Activation of Protein Kinase C{alpha} Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 2.7.11.13 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20938215&form=6&db=m Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through HO-1 blockage in cholangiocarcinoma cells. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280118&form=6&db=m Calcitonin gene-related peptide stimulates intracellular cAMP via a protein kinase C-controlled mechanism in human ocular ciliary epithelial cells. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309352&form=6&db=m Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316854&form=6&db=m Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1591273&form=6&db=m Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1607773&form=6&db=m [The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)] ongoing research,unassigned 4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1710480&form=6&db=m Simultaneous expression and regulation of G-CSF and IL-6 mRNA in adherent human monocytes and fibroblasts. ongoing research,unassigned 2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1824537&form=6&db=m Signal transduction pathway in gastric mucous cells. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1826686&form=6&db=m Early activation events render T cells susceptible to HIV-1-induced syncytia formation. Role of protein kinase C. therapeutic application,unassigned 2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1889509&form=6&db=m [The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)] ongoing research,unassigned 4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161881&form=6&db=m Expression of c-fos proto-oncogene in tumor-associated macrophages. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163626&form=6&db=m Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2178218&form=6&db=m Regulation of mRNA expression of 3 beta-hydroxy-5-ene steroid dehydrogenase in porcine granulosa cells in culture: a role for the protein kinase-C pathway. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552724&form=6&db=m Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555384&form=6&db=m Regulation of insulin-like growth factor-binding protein-1 production in human granulosa-luteal cells. ongoing research,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2561306&form=6&db=m Activation of protein kinase C via the T-cell receptor complex potentiates cyclic AMP responses in T-cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2777796&form=6&db=m Rat granulosa cell apolipoprotein E secretion. Regulation by cell cholesterol. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836242&form=6&db=m Differential regulation of hCG and progesterone secretion by cholera toxin and phorbol ester in human cytotrophoblasts. ongoing research,unassigned 3,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838273&form=6&db=m Variations in guanine-binding proteins (Gs, Gi) in cultured bovine adrenal cells. Consequences on the effects of phorbol ester and angiotensin II on adrenocorticotropin-induced and cholera-toxin-induced cAMP production. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846382&form=6&db=m Interactions of protein kinase C with receptor- and non-receptor-mediated cyclic AMP generation in swine granulosa cells. ongoing research,unassigned 2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846687&form=6&db=m Cholera toxin discriminates between murine T lymphocyte proliferation stimulated by activators of protein kinase C and proliferation stimulated by IL-2. Possible role for intracellular cAMP. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030703&form=6&db=m 12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031676&form=6&db=m Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin. therapeutic application,unassigned 4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120816&form=6&db=m Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126065&form=6&db=m Synergistic stimulation of S-adenosylmethionine decarboxylase activity by Ca2+ ionophore A23187, cholera toxin and 1-oleoyl-2-acetylglycerol. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3264254&form=6&db=m Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3522622&form=6&db=m Activation of protein kinase-C stimulates human granulosa-luteal cell prostacyclin production. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6320921&form=6&db=m Transmembrane signalling systems. ongoing research,unassigned 3,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523153&form=6&db=m Contribution of known mitogenic signaling pathways to induction of DNA synthesis in quiescent Chinese hamster fibroblasts. diagnostic usage,ongoing research,unassigned 2,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7534989&form=6&db=m Phosphatase inhibitors potentiate adrenergic-stimulated cAMP and cGMP production in rat pinealocytes. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615808&form=6&db=m Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7688126&form=6&db=m Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7854206&form=6&db=m Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907091&form=6&db=m Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7962103&form=6&db=m Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch. therapeutic application,unassigned 4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965816&form=6&db=m L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982455&form=6&db=m Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088367&form=6&db=m Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8192649&form=6&db=m Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C. causal interaction,unassigned 3,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8200555&form=6&db=m Relation between chloride secretion and intracellular cyclic adenosine monophosphate in a cloned human intestinal cell line HT-29 cl 19A. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8227196&form=6&db=m Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors. ongoing research,unassigned 3,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243300&form=6&db=m Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC. therapeutic application,unassigned 4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8463833&form=6&db=m Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8546817&form=6&db=m Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells. therapeutic application,unassigned 2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8561778&form=6&db=m Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP. therapeutic application,unassigned 4,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8667016&form=6&db=m Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861180&form=6&db=m Evaluation of cyclic AMP accumulation in EBV-transformed human B-lymphocytes: effects of dopamine agonists, isoproterenol, prostaglandin E1, cholera toxin, forskolin, and phorbol 12-myristate-13 acetate. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964084&form=6&db=m Evidence for protein kinase C pathway in the response of human peripheral blood mononuclear cells to cholera toxin. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9028864&form=6&db=m Signaling pathway triggered by a short immunomodulating peptide on human monocytes. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150281&form=6&db=m T cell antigen receptor dependent signalling in human lymphocytes: cholera toxin inhibits interleukin-2 receptor expression but not interleukin-2 synthesis by preventing activation of a protein kinase C isotype, PKC-alpha. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151357&form=6&db=m Increased cyclic AMP response to forskolin in Epstein-Barr virus-transformed human B-lymphocytes derived from schizophrenics. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167937&form=6&db=m Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196391&form=6&db=m Regulation of melanogenesis by human uveal melanocytes in vitro. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9670847&form=6&db=m Similar involvement of VIP receptor type I and type II in lymphocyte chemotaxis. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765365&form=6&db=m Depletion of protein kinase C-alpha by antisense oligonucleotides alters beta-adrenergic function and reverses the phorbol ester-induced reduction of isoproterenol-induced adenosine 3'-5'-cyclic monophosphate accumulation in murine Swiss 3T3 fibroblasts. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10231369&form=6&db=m Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10542136&form=6&db=m Cholera toxin induces tumor necrosis factor alpha production in human monocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604938&form=6&db=m Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10997924&form=6&db=m Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11007893&form=6&db=m Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11409691&form=6&db=m Transforming growth factor beta may act as an autocrine-survival-promoting factor for transformed trophoblasts. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566939&form=6&db=m Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12028130&form=6&db=m Regulation of apical transporter of L-DOPA in human intestinal Caco-2 cells. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15304551&form=6&db=m Kinin B1 receptors stimulate nitric oxide production in endothelial cells: signaling pathways activated by angiotensin I-converting enzyme inhibitors and peptide ligands. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15703462&form=6&db=m Differential effects of transforming growth factor-beta on the synthesis of connective tissue growth factor and vascular endothelial growth factor by peritoneal mesothelial cell. ongoing research,unassigned 2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18211822&form=6&db=m Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation. therapeutic application,unassigned 1,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18292205&form=6&db=m Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels. unassigned - 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18685019&form=6&db=m Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887106&form=6&db=m Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP. therapeutic application,unassigned 1,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8175138&form=6&db=m Inhibition of procoagulant activity of human monocytes by chenodeoxycholic acid: involvement of protein kinase C. causal interaction,unassigned 4,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10782902&form=6&db=m Role of glutathione and oxidative stress in phalloidin-induced cholestasis. ongoing research,unassigned 4,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12077103&form=6&db=m Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. unassigned - 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14679204&form=6&db=m Ca2+-dependent protein kinase C isoforms induce cholestasis in rat liver. unassigned - 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18972403&form=6&db=m Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat. ongoing research,unassigned 1,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20815017&form=6&db=m Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17?-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23209816&form=6&db=m Sequential activation of classic PKC and estrogen receptor ? is involved in estradiol 17ß-D-glucuronide-induced cholestasis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24115158&form=6&db=m G-protein-coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis. therapeutic application,unassigned 1,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24700589&form=6&db=m Role of protein kinase C isoforms in bile formation and cholestasis. causal interaction,unassigned 1,0 2.7.11.13 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25813982&form=6&db=m EGFR participates downstream of ER? in estradiol-17?-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets. therapeutic application,unassigned 1,0 2.7.11.13 Cholestasis, Intrahepatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809379&form=6&db=m ATPase Class I Type 8B Member 1 and Protein Kinase C-zeta Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes. ongoing research,unassigned 2,0 2.7.11.13 Cholesteatoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10569408&form=6&db=m Terminal differentiation of epithelial cells in middle ear cholesteatoma: investigation of patterns of expression of protein kinase C-delta and protein kinase C-eta. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Cholesteatoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513304&form=6&db=m Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.7.11.13 Cholesteatoma, Middle Ear http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10569408&form=6&db=m Terminal differentiation of epithelial cells in middle ear cholesteatoma: investigation of patterns of expression of protein kinase C-delta and protein kinase C-eta. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Choline Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1452945&form=6&db=m Choline: an important nutrient in brain development, liver function and carcinogenesis. unassigned - 2.7.11.13 Choline Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7645429&form=6&db=m Choline and hepatocarcinogenesis in the rat. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Choline Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7859365&form=6&db=m Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ongoing research,unassigned 1,0 2.7.11.13 Choline Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8420980&form=6&db=m Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Choline Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539234&form=6&db=m Choline deficiency activates phospholipases A2 and C in rat liver without affecting the activity of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18827568&form=6&db=m Targeting the mammalian target of rapamycin in myxoid chondrosarcoma. therapeutic application,unassigned 1,0 2.7.11.13 Chondrosarcoma, Mesenchymal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12817616&form=6&db=m Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. therapeutic application,unassigned 1,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309352&form=6&db=m Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316854&form=6&db=m Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1854347&form=6&db=m Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line. ongoing research,unassigned 3,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1889509&form=6&db=m [The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)] ongoing research,unassigned 4,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840269&form=6&db=m Epidermal growth factor but not insulin-like growth factor-I potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844818&form=6&db=m Cyclic AMP and phorbol esters interact synergistically to regulate expression of the chorionic gonadotropin genes. therapeutic application,unassigned 3,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030703&form=6&db=m 12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3264254&form=6&db=m Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8782085&form=6&db=m Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9166760&form=6&db=m Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine/threonine phosphatases. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9778120&form=6&db=m Downregulation of protein kinase C by phorbol ester increases expression of epidermal growth factor receptors in transformed trophoblasts and amplifies human chorionic gonadotropin production. ongoing research,unassigned 3,0 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313339&form=6&db=m DNA binding of TEA/ATTS domain factors is regulated by protein kinase C phosphorylation in human choriocarcinoma cells. unassigned - 2.7.11.13 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11742812&form=6&db=m Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. ongoing research,unassigned 3,0 2.7.11.13 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8158498&form=6&db=m Chemoluminescence generation and MTT dye reduction by polymorphonuclear leukocytes from periodontal disease patients. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Cleft Palate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10662608&form=6&db=m Novel mechanism of protein kinase C inhibition involving the pseudosubstrate region by secalonic acid D in vitro. ongoing research,unassigned 3,0 2.7.11.13 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070033&form=6&db=m Protein kinase C mediates experimental colitis in the rat. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778918&form=6&db=m Alterations in protein kinase C isoforms in experimentally-induced colitis in the rat. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17060026&form=6&db=m Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18155708&form=6&db=m Protein kinase C theta plays a fundamental role in different types of chronic colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21080461&form=6&db=m Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21744423&form=6&db=m Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis. therapeutic application,unassigned 2,0 2.7.11.13 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22093175&form=6&db=m The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1589704&form=6&db=m Protein kinase C activity of colonic mucosa in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1294268&form=6&db=m Induction of ornithine decarboxylase in normal and protein kinase C--depleted human colon carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693276&form=6&db=m Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1755860&form=6&db=m The modulation of growth by HMBA in PKC overproducing HT29 colon cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1844247&form=6&db=m The roles of specific isoforms of protein kinase C in growth control and human colon cancer. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1997199&form=6&db=m Decreased levels of 1,2-sn-diacylglycerol in human colon tumors. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2017156&form=6&db=m In vitro model for intrinsic drug resistance: effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2222808&form=6&db=m Differing roles of protein kinase C on the antiproliferative effects of tumor necrosis factor alpha and beta on LoVo cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2241943&form=6&db=m Protein kinase C activation selectively increases mRNA levels for one of the regulatory subunits (RI alpha) of cAMP-dependent protein kinases in HT-29 cells. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2278882&form=6&db=m Phorbol esters activate proteoglycan metabolism in human colon cancer cells en route to terminal differentiation. causal interaction,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2388620&form=6&db=m Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3048655&form=6&db=m Modulation of HT-29 human colonic cancer cell differentiation with calmidazolium and 12-O-tetradecanoylphorbol-13-acetate. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7767974&form=6&db=m Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7815176&form=6&db=m Dietary fat and fiber alter rat colonic protein kinase C isozyme expression. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8053934&form=6&db=m Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8394671&form=6&db=m Analysis of calcium-dependent protein kinase-C isoenzymes in intrinsically resistant cloned lines of LoVo cells: reversal of resistance by kinase inhibitor 1-(5-isoquinolinylsulfonyl) 2-methylpiperazine. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8532710&form=6&db=m The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626698&form=6&db=m Increased expression of protein kinase C beta activates ERK3. unassigned - 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8825530&form=6&db=m Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+: a protein kinase C effect. ongoing research,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8913270&form=6&db=m Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells. ongoing research,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9054628&form=6&db=m Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes. therapeutic application,unassigned 2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9166410&form=6&db=m Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes. ongoing research,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9311948&form=6&db=m Dietary fat and fiber modulate the effect of carcinogen on colonic protein kinase C lambda expression in rats. ongoing research,unassigned 2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498273&form=6&db=m Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9500474&form=6&db=m Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547673&form=6&db=m Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9649461&form=6&db=m Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9820166&form=6&db=m Tissue factor activity of SW-480 human colon adenocarcinoma cells is modulated by thrombin and protein kinase C activation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823967&form=6&db=m Inhibition of protein kinase C-alpha isoform enhances the P-glycoprotein expression and the survival of LoVo human colon adenocarcinoma cells to doxorubicin exposure. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10357776&form=6&db=m Activation of protein kinase C augments butyrate-induced differentiation and turnover in human colonic epithelial cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485493&form=6&db=m CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10500067&form=6&db=m Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545022&form=6&db=m TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment. therapeutic application,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10585423&form=6&db=m 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10623886&form=6&db=m Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10673914&form=6&db=m Phospholipid fatty acid composition and protein kinase C activity in the large intestine of rats fed on butter and coconut-oil diets. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10675484&form=6&db=m Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10789557&form=6&db=m Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10938388&form=6&db=m Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11190577&form=6&db=m Modulation of protein kinase C in antitumor treatment. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245437&form=6&db=m Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375951&form=6&db=m PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673641&form=6&db=m Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats. unassigned - 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819585&form=6&db=m Effect of gastrin on protein kinase C and its subtype in human colon cancer cell line SW480. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836445&form=6&db=m Detection of genes expressed in primary colon cancers by in situ hybridisation: overexpression of RACK 1. unassigned - 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12058013&form=6&db=m Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203364&form=6&db=m Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15037605&form=6&db=m Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172114&form=6&db=m Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322124&form=6&db=m Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386430&form=6&db=m p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494216&form=6&db=m Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15571286&form=6&db=m Combinations of 5-fluorouracil with UCN-01 or staurosporine. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15601585&form=6&db=m PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16122920&form=6&db=m Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16434969&form=6&db=m Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16523009&form=6&db=m Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16631161&form=6&db=m Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells. causal interaction,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940160&form=6&db=m Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17236547&form=6&db=m [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17406816&form=6&db=m Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18694510&form=6&db=m Role of Caveolin 1, E-Cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147581&form=6&db=m Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19187120&form=6&db=m Stimulation of protein kinase Calpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221092&form=6&db=m Protein kinase Cbeta is an effective target for chemoprevention of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232344&form=6&db=m PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19360323&form=6&db=m Butyrate-induced alterations of phosphoinositide metabolism, protein kinase C activity and reduced CD44 variant expression in HT-29 colon cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19417139&form=6&db=m Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19833168&form=6&db=m Rottlerin induces Heme Oxygenase-1(HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885570&form=6&db=m The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093383&form=6&db=m Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20141613&form=6&db=m Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188713&form=6&db=m Protein kinase Cgamma in colon cancer cells: expression, Thr514 phosphorylation and sensitivity to butyrate-mediated upregulation as related to the degree of differentiation. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20632438&form=6&db=m Effect of soy saponin on the growth of human colon cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552934&form=6&db=m Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22750245&form=6&db=m High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24920238&form=6&db=m Protein kinase C ? regulates survivin expression and inhibits apoptosis in colon cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28561935&form=6&db=m Clinicopathological characteristics of KIT and protein kinase C-? expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour. causal interaction,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29069771&form=6&db=m Expression of protein kinase C gamma promotes cell migration in colon cancer. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289336&form=6&db=m Protein Kinase C Inhibitors Selectively Modulate Dynamics of Cell Adhesion Molecules and Cell Death in Human Colon Cancer Cells. ongoing research,unassigned 3,0 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30841571&form=6&db=m The Role of M3 Muscarinic Receptor Ligand-Induced Kinase Signaling in Colon Cancer Progression. unassigned - 2.7.11.13 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31545907&form=6&db=m Extracellular pyruvate kinase M2 facilitates cell migration by upregulating claudin-1 expression in colon cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1586595&form=6&db=m Correlation between protein kinase C activity and histopathological criteria in human colorectal adenoma. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1727670&form=6&db=m Protein kinase C activity in human colonic adenoma and colorectal carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1860726&form=6&db=m Protein kinase C activity as marker for colorectal cancer. diagnostic usage,therapeutic application,unassigned 4,1,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7705931&form=6&db=m Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7817999&form=6&db=m Analyses of protein kinase C isoform expression in a colorectal cancer liver metastasis model. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7861778&form=6&db=m Differential expression of protein kinase C isoforms in human colorectal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8404381&form=6&db=m Decreased levels of protein kinase C enzyme activity and protein kinase C mRNA in primary colon tumors. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556213&form=6&db=m Down-regulation of protein kinase C-alpha detected in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9935190&form=6&db=m Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphology. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12114419&form=6&db=m Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376294&form=6&db=m Effect of protein kinase C on multidrug resistance of multidrug-resistant colorectal cancer LoVo/Adr cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161701&form=6&db=m Pak-1 expression increases with progression of colorectal carcinomas to metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313680&form=6&db=m Effects of cell membrane phospholipid level and protein kinase C isoenzyme expression on hepatic metastasis of colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15647851&form=6&db=m Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15975962&form=6&db=m Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16523009&form=6&db=m Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849539&form=6&db=m Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16886117&form=6&db=m [Target lethal effect of recombinant soluble Fas coupled with protein kinase C inhibitor on colorectal carcinoma cells] ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17965192&form=6&db=m Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19277684&form=6&db=m Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509063&form=6&db=m A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19901015&form=6&db=m A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer. causal interaction,unassigned 1,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25486357&form=6&db=m Protein kinase C ? inhibition by enzastaurin leads to mitotic missegregation and preferential cytotoxicity toward colorectal cancer cells with chromosomal instability (CIN). causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884861&form=6&db=m Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26989024&form=6&db=m Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29029434&form=6&db=m Silencing protein kinase C ? by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation. unassigned - 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29520890&form=6&db=m Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30417717&form=6&db=m The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells. unassigned - 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30675313&form=6&db=m Nonylphenol promotes the proliferation of colorectal cancer COLO205 cells by upregulating the expression of protein kinase C ?. ongoing research,unassigned 1,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775562&form=6&db=m Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway. therapeutic application,unassigned 1,0 2.7.11.13 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31810137&form=6&db=m Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Coma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8490715&form=6&db=m Brain protein kinase C assay using MARCKS substrate reveals no translocation due to profound insulin-induced hypoglycemia. ongoing research,unassigned 3,0 2.7.11.13 Common Variable Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1863999&form=6&db=m Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Common Variable Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2019009&form=6&db=m Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency. diagnostic usage,unassigned 3,0 2.7.11.13 Common Variable Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8854087&form=6&db=m Abnormal B cell response of protein kinase C in some common variable immunodeficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.7.11.13 Common Variable Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9200189&form=6&db=m Common variable immunodeficiency associated with myelocathexis and altered membrane sodium-proton antiport. causal interaction,unassigned 2,0 2.7.11.13 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9176320&form=6&db=m Do adult rat ventricular myocytes express protein kinase C-alpha? causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212452&form=6&db=m [Advances in the studies of teratospermia-related genes]. therapeutic application,unassigned 2,0 2.7.11.13 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7509260&form=6&db=m Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521261&form=6&db=m Sensitivity to protein kinase C inhibitors of nicardipine-insensitive component of high K+ contracture in rat and guinea-pig aorta. causal interaction,unassigned 1,0 2.7.11.13 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8162962&form=6&db=m Schistosoma mansoni: myogenic characteristics of phorbol ester-induced muscle contraction. therapeutic application,unassigned 2,0 2.7.11.13 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9743412&form=6&db=m Mechanisms of isoflurane-increased submaximum Ca2+-activated force in rabbit skinned femoral arterial strips. causal interaction,unassigned 1,0 2.7.11.13 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424103&form=6&db=m The neuropeptide proctolin potentiates contractions and reduces cGMP concentration via a PKC-dependent pathway. therapeutic application,unassigned 1,0 2.7.11.13 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18597842&form=6&db=m Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms. therapeutic application,unassigned 1,0 2.7.11.13 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28479286&form=6&db=m Phorbol 12,13-dibutyrate-induced protein kinase C activation triggers sustained contracture in human myometrium in vitro. therapeutic application,unassigned 1,0 2.7.11.13 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14600145&form=6&db=m Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15364862&form=6&db=m Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts. therapeutic application,unassigned 4,0 2.7.11.13 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867794&form=6&db=m Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.7.11.13 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9345290&form=6&db=m Role of protein kinase C-alpha in activation of ecto-5'-nucleotidase in the preconditioned canine myocardium. unassigned - 2.7.11.13 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234167&form=6&db=m Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18061124&form=6&db=m Ischemic preconditioning modulates mitochondrial respiration, irrespective of the employed signal transduction pathway. unassigned - 2.7.11.13 Coronary Vasospasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9227542&form=6&db=m Ca2+ release mechanism of primate drug-induced coronary vasospasm. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Coronary Vasospasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710137&form=6&db=m Preconditioning of coronary artery against vasoconstriction by endothelin-1 and prostaglandin F2alpha during repeated downregulation of epsilon-protein kinase C. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Coronary Vasospasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11230325&form=6&db=m Endothelin-1 enhances eicosanoids-induced coronary smooth muscle contraction by activating specific protein kinase C isoforms. unassigned - 2.7.11.13 Coronary Vasospasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11230335&form=6&db=m Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon. causal interaction,unassigned 4,0 2.7.11.13 Coronary Vasospasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882605&form=6&db=m Endothelin-1--induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways. causal interaction,unassigned 3,0 2.7.11.13 Coronary Vasospasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14592852&form=6&db=m Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm. ongoing research,unassigned 1,0 2.7.11.13 Corticobasal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Cowpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8999887&form=6&db=m Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. unassigned - 2.7.11.13 Craniosynostoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10329600&form=6&db=m Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Craniosynostoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11337381&form=6&db=m Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1. unassigned - 2.7.11.13 Craniosynostoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11341328&form=6&db=m Role of N-cadherin and protein kinase C in osteoblast gene activation induced by the S252W fibroblast growth factor receptor 2 mutation in Apert craniosynostosis. unassigned - 2.7.11.13 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824513&form=6&db=m Granulocyte-macrophage colony-stimulating factor and interleukin-3 potentiate interferon-gamma-mediated endothelin production by human monocytes: role of protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24244878&form=6&db=m Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin? causal interaction,unassigned 3,0 2.7.11.13 Cryptococcosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18489726&form=6&db=m Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation. unassigned - 2.7.11.13 Cryptosporidiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32019797&form=6&db=m Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA. causal interaction,unassigned 3,0 2.7.11.13 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7951545&form=6&db=m ACTH and phorbol ester stimulated redistribution of protein kinase C in human cortisol-producing adrenal adenoma. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18030748&form=6&db=m [Effect of adrenocorticotropic hormone on the caspase-3 level and DNA fragmentation in hyperplasia tissue of human adrenals] ongoing research,unassigned 2,0 2.7.11.13 Cystadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888898&form=6&db=m Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1377674&form=6&db=m Phosphorylation of the cystic fibrosis transmembrane conductance regulator. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379589&form=6&db=m Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1383033&form=6&db=m Effect of modulation of protein kinase C on the cAMP-dependent chloride conductance in T84 cells. ongoing research,unassigned 1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659349&form=6&db=m Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698296&form=6&db=m Fatty acids inhibit apical membrane chloride channels in airway epithelia. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1964813&form=6&db=m Further evidence for abnormal protein kinase C regulation of macromolecule secretion in fibroblasts from cystic fibrosis patients. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2472006&form=6&db=m Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3345834&form=6&db=m Phorbol ester-induced protein kinase C translocation and lysosomal enzyme release in normal and cystic fibrosis fibroblasts. ongoing research,unassigned 2,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7513122&form=6&db=m Phosphorylation of vimentin is an intermediate step in protein kinase C-mediated glycoconjugate secretion. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7684379&form=6&db=m Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene. therapeutic application,unassigned 1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7686146&form=6&db=m Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9030559&form=6&db=m Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514538&form=6&db=m Role for PKC alpha and PKC epsilon in down-regulation of CFTR mRNA in a human epithelial liver cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9594016&form=6&db=m Regulation of CFTR by protein phosphatase 2B and protein kinase C. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9688861&form=6&db=m PKC regulation of cardiac CFTR Cl- channel function in guinea pig ventricular myocytes. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9730948&form=6&db=m Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation. therapeutic application,unassigned 1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9814985&form=6&db=m Antisense oligonucleotide to PKC-epsilon alters cAMP-dependent stimulation of CFTR in Calu-3 cells. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10096895&form=6&db=m Regulation of recombinant cardiac cystic fibrosis transmembrane conductance regulator chloride channels by protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10209208&form=6&db=m Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells. ongoing research,unassigned 2,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10634929&form=6&db=m PKC signaling in CF/T43 cell line: regulation of NKCC1 by PKC-delta isotype. causal interaction,unassigned 2,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238015&form=6&db=m Differential regulation of Cl- transport proteins by PKC in Calu-3 cells. ongoing research,unassigned 1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342000&form=6&db=m The phorbol ester PMA and cyclic AMP activate different Cl(-) and HCO3(-) fluxes in C127 cells expressing CFTR. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956211&form=6&db=m Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12588899&form=6&db=m Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14695900&form=6&db=m Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289377&form=6&db=m Targeted inactivation of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409124&form=6&db=m Role of the scaffold protein RACK1 in apical expression of CFTR. ongoing research,unassigned 2,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17613530&form=6&db=m Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly. ongoing research,unassigned 3,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17692578&form=6&db=m Liquid movement across the surface epithelium of large airways. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20185575&form=6&db=m After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes. unassigned - 2.7.11.13 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29257318&form=6&db=m Identification of key pathways and genes in Barrett's esophagus using integrated bioinformatics methods. unassigned - 2.7.11.13 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28882559&form=6&db=m Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis. therapeutic application,unassigned 1,0 2.7.11.13 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786956&form=6&db=m Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Cystitis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882787&form=6&db=m Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis. unassigned - 2.7.11.13 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057895&form=6&db=m Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease. causal interaction,unassigned 4,0 2.7.11.13 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17314404&form=6&db=m Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture. diagnostic usage,unassigned 1,0 2.7.11.13 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18280471&form=6&db=m Acanthamoeba castellanii: Gene profile of encystation by ESTs analysis and KOG assignment. therapeutic application,unassigned 1,0 2.7.11.13 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21276446&form=6&db=m Expression levels of encystation mediating factors in fresh strain of Acanthamoeba castellanii cyst ESTs. unassigned - 2.7.11.13 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830287&form=6&db=m Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2. therapeutic application,unassigned 1,0 2.7.11.13 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30652979&form=6&db=m Genetics of polycystic liver diseases. causal interaction,unassigned 1,0 2.7.11.13 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980013&form=6&db=m Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7548120&form=6&db=m Infrared spectroscopic study of the interaction of diacylglycerol with phosphatidylserine in the presence of calcium. therapeutic application,unassigned 2,0 2.7.11.13 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9203370&form=6&db=m Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9357764&form=6&db=m Effects of PKC alpha activation on Ca2+ pump and K(Ca) channel in deoxygenated sickle cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23541371&form=6&db=m Endothelin-3 Expression in the Subfornical Organ Enhances the Sensitivity of Nax, the Brain Sodium-Level Sensor, to Suppress Salt Intake. unassigned - 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18313045&form=6&db=m Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats. causal interaction,unassigned 3,0 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21175182&form=6&db=m Fluorescent-responsive synthetic C1b domains of protein kinase C? as reporters of specific high-affinity ligand binding. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22840750&form=6&db=m Activation of protein kinase C isozymes for the treatment of dementias. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22936322&form=6&db=m Effect of Huannao Yicong Prescription () extract on ?-Amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse. ongoing research,unassigned 2,0 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109829&form=6&db=m Screening for protein kinase C ligands using fluorescence resonance energy transfer. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29517836&form=6&db=m Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34338277&form=6&db=m Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9878848&form=6&db=m Responses to cyclic AMP is impaired in the twitcher Schwann cells in vitro. therapeutic application,unassigned 1,0 2.7.11.13 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11519722&form=6&db=m Remyelination in vitro following protein kinase C activator-induced demyelination. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15195086&form=6&db=m Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. causal interaction,unassigned 2,0 2.7.11.13 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854053&form=6&db=m Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury. unassigned - 2.7.11.13 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338269&form=6&db=m Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931565&form=6&db=m Inhibition of protein kinase C promotes dengue virus replication. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,2,0 2.7.11.13 Dermatitis, Allergic Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547380&form=6&db=m Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Dermatitis, Allergic Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12823308&form=6&db=m Overexpression of skin protein kinase C-alpha in anagen hair follicles during induced growth of mouse hair. unassigned - 2.7.11.13 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547380&form=6&db=m Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7679016&form=6&db=m Influence of protein kinase C activation on basophils from patients with atopic dermatitis in comparison with nonatopic controls. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27304220&form=6&db=m TSLP regulates eosinophil migration via phosphorylation of L-plastin in atopic dermatitis. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27776525&form=6&db=m Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848737&form=6&db=m Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review. therapeutic application,unassigned 1,0 2.7.11.13 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2600272&form=6&db=m Flow cytometric analysis of protein kinase C in lymph node cells during the induction phase of contact hypersensitivity reaction. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547380&form=6&db=m Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9687030&form=6&db=m Down-regulation of protein kinase C isoforms in irritant contact dermatitis. therapeutic application,unassigned 1,0 2.7.11.13 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10091479&form=6&db=m The potential role of skin protein kinase C isoforms alpha and delta in mouse hair growth induced by diphencyprone-allergic contact dermatitis. unassigned - 2.7.11.13 Dermatitis, Exfoliative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547380&form=6&db=m Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Dermatitis, Phototoxic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9630009&form=6&db=m Involvement of reactive oxygen species, protein kinase C, and tyrosine kinase in prostaglandin E2 production in Balb/c 3T3 mouse fibroblast cells by quinolone phototoxicity. therapeutic application,unassigned 1,0 2.7.11.13 Dermatofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406344&form=6&db=m Mitogenic activity of dermatofibrosarcoma protuberans is mediated via an extracellular signal related kinase dependent pathway. therapeutic application,unassigned 2,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3002888&form=6&db=m Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve. Implications for (Na,K)-ATPase regulation and diabetic complications. unassigned - 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8609230&form=6&db=m Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8614835&form=6&db=m Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621017&form=6&db=m LY290181, an inhibitor of diabetes-induced vascular dysfunction, blocks protein kinase C-stimulated transcriptional activation through inhibition of transcription factor binding to a phorbol response element. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8654704&form=6&db=m Diabetic complications and the mechanism of the hyperglycaemia-induced damage to the mt DNA of cultured vascular endothelial cells: (II) The involvement of protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9021343&form=6&db=m Activation of human platelet protein kinase C-beta 2 in vivo in response to acute hyperglycemia. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9562601&form=6&db=m Antiproliferative naphthopyrans: biological activity, mechanistic studies and therapeutic potential. therapeutic application,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9604860&form=6&db=m Protein kinase C activation and the development of diabetic complications. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9818205&form=6&db=m Protein kinases C: potential targets for intervention in diabetic nephropathy. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9864462&form=6&db=m Molecular mechanisms of diabetic complications. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9867062&form=6&db=m Pathophysiology of diabetic nephropathy. causal interaction,unassigned 1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10232703&form=6&db=m Effects of the diacylglycerol complexing agent, cremophor, on nerve-conduction velocity and perfusion in diabetic rats. unassigned - 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10342822&form=6&db=m Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499500&form=6&db=m Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10751230&form=6&db=m AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11037624&form=6&db=m The role of protein kinase C in the development of the complications of diabetes. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576522&form=6&db=m Effect of the postprandial state on nontraditional risk factors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11672473&form=6&db=m Increased platelet aggregation in diabetic patients with microangiopathy despite good glycemic control. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795119&form=6&db=m [Tissular toxicity of glucose and therapeutic perspectives] causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12441406&form=6&db=m Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12494366&form=6&db=m [The role of protein kinase C in the pathophysiology of diabetic retinopathy] causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954365&form=6&db=m Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14737743&form=6&db=m The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15496608&form=6&db=m Altered protein kinase C activation associated with rat embryonic dysmorphogenesis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15532720&form=6&db=m Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: role of glucose-induced PKC activity. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589066&form=6&db=m Future therapy of diabetes mellitus. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592846&form=6&db=m [Pharmacological treatment of diabetic retinopathy] causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15734861&form=6&db=m Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15999687&form=6&db=m [Protein kinase C activation and diabetic complications] causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026323&form=6&db=m Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140162&form=6&db=m An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17115692&form=6&db=m Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485142&form=6&db=m Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18488224&form=6&db=m NOX enzymes and diabetic complications. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800628&form=6&db=m [Investigation of a novel mechanism of diabetic complications: impacts of mitochondrial reactive oxygen species] causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18852331&form=6&db=m Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19275668&form=6&db=m Aminoacid support in the prevention of diabetes and diabetic complications. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449764&form=6&db=m [Potential new antidiabetics for the next decade] causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19614949&form=6&db=m Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885168&form=6&db=m The beta-specific protein kinase C inhibitor ruboxistaurin (LY333531) suppresses glucose-induced adhesion of human monocytes to endothelial cells in vitro. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19929710&form=6&db=m Ruboxistaurin: PKC-beta inhibition for complications of diabetes. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179320&form=6&db=m Protein kinase Cbeta mediates hepatic induction of sterol regulatory element-binding protein-1c by insulin. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20431074&form=6&db=m Activation of protein kinase C isoforms and its impact on diabetic complications. causal interaction,unassigned 1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21805047&form=6&db=m Proteomic analysis identifies nuclear protein effectors in PKC-delta signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21838680&form=6&db=m The Role of Oxidative Stress in the Pathogenesis of Type 2 Diabetes Mellitus Micro- and Macrovascular Complications:Avenues for a Mechanistic-Based Therapeutic Approach. ongoing research,unassigned 1,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22404224&form=6&db=m Protein kinase C ?II in diabetic complications: survey of structural, biological and computational studies. unassigned - 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22727642&form=6&db=m Identification of specific features of inhibition of PKC?II and its potential lead by shape-based virtual screening and molecular docking studies. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22829732&form=6&db=m Designing of Protein Kinase C ?-II Inhibitors against Diabetic complications: Structure Based Drug Design, Induced Fit docking and analysis of active site conformational changes. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770211&form=6&db=m Inhibition of protein kinase C ?II isoform rescues glucose toxicity-induced cardiomyocyte contractile dysfunction: role of mitochondria. unassigned - 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24269213&form=6&db=m Inhibition of protein kinase C ?II isoform ameliorates methylglyoxal advanced glycation endproduct-induced cardiomyocyte contractile dysfunction. causal interaction,unassigned 2,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631337&form=6&db=m Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C ? in a mouse model of diabetic retinopathy. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25859860&form=6&db=m Role of complement and complement regulatory proteins in the complications of diabetes. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648059&form=6&db=m Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27467877&form=6&db=m Targeting PKC-? II by Peptides and Peptidomimetics Derived from RACK 1: An In Silico Approach. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28966330&form=6&db=m High Glucose Stimulates Mineralocorticoid Receptor Transcriptional Activity Through the Protein Kinase C ? Signaling. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29744369&form=6&db=m Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice. causal interaction,unassigned 2,0 2.7.11.13 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30934385&form=6&db=m Role of protein kinase C in diabetic complications. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25006961&form=6&db=m Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus. therapeutic application,unassigned 1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1725424&form=6&db=m Down-regulation of endothelin-1 receptors by protein kinase C in streptozotocin diabetic rats. causal interaction,unassigned 1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2022734&form=6&db=m Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7924872&form=6&db=m Vascular permeability in diabetics and implications for therapy. unassigned - 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058653&form=6&db=m [Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8614835&form=6&db=m Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9225570&form=6&db=m [Red cell Na+/H+ exchange and role of protein kinase C in its stimulation in diabetes mellitus, essential hypertension and nephropathy] causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256480&form=6&db=m Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9258280&form=6&db=m Increased intracellular calcium and altered phorbol dibutyrate binding to intact platelets in young subjects with insulin-dependent and non-insulin-dependent diabetes mellitus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9324113&form=6&db=m Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle? causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9462865&form=6&db=m Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9818205&form=6&db=m Protein kinases C: potential targets for intervention in diabetic nephropathy. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10361857&form=6&db=m Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10588367&form=6&db=m Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10615429&form=6&db=m Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10751221&form=6&db=m Renal angiotensin II receptors and protein kinase C in diabetic rats: effects of insulin and ACE inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104300&form=6&db=m Protein kinase C activation and its pharmacological inhibition in vascular disease. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270675&form=6&db=m Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro. unassigned - 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788369&form=6&db=m Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11940543&form=6&db=m Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12435880&form=6&db=m Protein kinase C beta isoenzymes in diabetic kidneys and their relation to nephroprotective actions of the ACE inhibitor lisinopril. unassigned - 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954365&form=6&db=m Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491081&form=6&db=m [Renal disease in diabetics. Immunological bases of tubule-interstitial fibrosis and glomeruloesclerosis. Current therapeutic approach] causal interaction,unassigned 3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576967&form=6&db=m [Effects of calcium channel blockers in atherosclerosis and cardiovascular event and oxidative vascular damage] causal interaction,unassigned 4,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15894568&form=6&db=m PKC-{varepsilon}-dependent survival signals in diabetic hearts. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837815&form=6&db=m Effects of Blocking the Renin-Angiotensin System on Expression and Translocation of Protein Kinase C Isoforms in the Kidney of Diabetic Rats. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693752&form=6&db=m Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18615853&form=6&db=m Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885168&form=6&db=m The beta-specific protein kinase C inhibitor ruboxistaurin (LY333531) suppresses glucose-induced adhesion of human monocytes to endothelial cells in vitro. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20053941&form=6&db=m Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23671888&form=6&db=m Hypermethylation of the PRKCZ Gene in Type 2 Diabetes Mellitus. ongoing research,unassigned 3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23766264&form=6&db=m PKC? promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24794552&form=6&db=m Protein kinase C in enhanced vascular tone in diabetes mellitus. causal interaction,diagnostic usage,unassigned 2,3,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24954177&form=6&db=m Diabetic hearts have lower basal urocortin levels that fail to increase after cardioplegic arrest: Association with increased apoptosis and postsurgical cardiac dysfunction. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237474&form=6&db=m Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28359367&form=6&db=m Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide. causal interaction,unassigned 1,0 2.7.11.13 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9714084&form=6&db=m Protein kinase C isozymes in skeletal muscles during the early stage of genetic and streptozocin diabetes. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1668730&form=6&db=m Stimulation of the human leucocyte Na+/H+ antiport by D-glucose is mediated by protein kinase C. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458880&form=6&db=m Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12919931&form=6&db=m Alterations in rat coronary vasoreactivity and vascular protein kinase C isoforms in Type 1 diabetes. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16330008&form=6&db=m Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18937679&form=6&db=m No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C>T and c.-546C>G with diabetic nephropathy in Type 1 diabetes. unassigned - 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038746&form=6&db=m Protein kinase C-dependent NAD(P)H oxidase activation induced by type 1 diabetes in renal medullary thick ascending limb. ongoing research,unassigned 1,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22117100&form=6&db=m Effect of captopril and the bradykinin-PKC pathway on ROS production in type 1 diabetic rats. ongoing research,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203737&form=6&db=m NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes. therapeutic application,unassigned 1,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26802537&form=6&db=m Viral vector mediated continuous expression of interleukin-10 in DRG alleviates pain in type 1 diabetic animals. ongoing research,unassigned 2,0 2.7.11.13 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32326759&form=6&db=m Feature article: Inhibition of protein kinase C beta phosphorylation activates nuclear factor-kappa B and improves postischemic recovery in type 1 diabetes. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336404&form=6&db=m The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1861631&form=6&db=m Impaired translocation of protein kinase C activity in human non-insulin-dependent diabetes mellitus. ongoing research,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7769136&form=6&db=m Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9021343&form=6&db=m Activation of human platelet protein kinase C-beta 2 in vivo in response to acute hyperglycemia. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304414&form=6&db=m Platelet protein kinase C isoform content in type 2 diabetes complicated with retinopathy and nephropathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788369&form=6&db=m Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12372842&form=6&db=m Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882907&form=6&db=m Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise. unassigned - 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882908&form=6&db=m Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14636302&form=6&db=m Increased skeletal muscle expression of PKC-theta but not PKC-alpha mRNA in type 2 diabetes: inverse relationship with in-vivo insulin sensitivity. unassigned - 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15384959&form=6&db=m Polymorphisms in the 5'-upstream region of the PKCbeta gene in Japanese patients with Type 2 diabetes. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649404&form=6&db=m PKCepsilon induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15891936&form=6&db=m Molecular targeting of pancreatic disorders. therapeutic application,unassigned 1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16330008&form=6&db=m Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16504599&form=6&db=m Diabetes: assessing the pipeline. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17028667&form=6&db=m Ruboxistaurin. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17028898&form=6&db=m Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans. unassigned - 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130651&form=6&db=m Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17318260&form=6&db=m Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17904375&form=6&db=m Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908560&form=6&db=m Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18535477&form=6&db=m Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18586909&form=6&db=m Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18613220&form=6&db=m Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18615853&form=6&db=m Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758661&form=6&db=m Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18793161&form=6&db=m The diverse roles of protein kinase C in pancreatic beta-cell function. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18972094&form=6&db=m Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19401415&form=6&db=m Deletion of PKC{varepsilon} selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse {beta}-cells. causal interaction,unassigned 2,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20013954&form=6&db=m Role of PKCzeta translocation in the development of type 2 diabetes in rats following continuous glucose infusion. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20444914&form=6&db=m Inhibition of Protein Kinase C{beta} Does Not Improve Endothelial Function in Type 2 Diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,2 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20714510&form=6&db=m Residues 762-801 of PLD1 mediate the interaction with PED/PEA15. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862498&form=6&db=m Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23630454&form=6&db=m PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23671888&form=6&db=m Hypermethylation of the PRKCZ Gene in Type 2 Diabetes Mellitus. ongoing research,unassigned 3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23933835&form=6&db=m Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression. causal interaction,unassigned 3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24705256&form=6&db=m Aortic superoxide production at the early hyperglycemic stage in a rat type 2 diabetes model and the effects of pravastatin. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25387400&form=6&db=m Retraction Note: abstracts of the 47th Annual Meeting of the EASD, Lisbon 2011. 'Reduced syntaxin-5 in skeletal muscle of patients with type 2 diabetes is linked to increased diacylglycerol, activation of PKCtheta and impaired insulin signalling'. causal interaction,unassigned 1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237474&form=6&db=m Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26398746&form=6&db=m Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes. ongoing research,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485395&form=6&db=m Correction: Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes. ongoing research,unassigned 3,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648059&form=6&db=m Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28359367&form=6&db=m Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide. causal interaction,unassigned 1,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31147882&form=6&db=m Pericytes in Type 2 Diabetes. causal interaction,unassigned 4,0 2.7.11.13 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31387939&form=6&db=m The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling. unassigned - 2.7.11.13 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272035&form=6&db=m Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. ongoing research,unassigned 1,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1713580&form=6&db=m Expression of genes related to the extracellular matrix in human endothelial cells. Differential modulation by elevated glucose concentrations, phorbol esters, and cAMP. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2740348&form=6&db=m Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058653&form=6&db=m [Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9018373&form=6&db=m Production of type IV collagen and 72-kDa gelatinase by human endothelial cells cultured in high glucose. Effects of a protein kinase C inhibitor, GF 109203X. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9462865&form=6&db=m Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10406523&form=6&db=m The role of protein kinase C activation in the pathogenesis of diabetic vascular complications. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10447525&form=6&db=m Protein kinase C effects on nerve function, perfusion, Na(+), K(+)-ATPase activity and glutathione content in diabetic rats. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304414&form=6&db=m Platelet protein kinase C isoform content in type 2 diabetes complicated with retinopathy and nephropathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11440358&form=6&db=m Diabetic vascular disease and the rising star of protein kinase C. unassigned - 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11903393&form=6&db=m Protein kinase C and the development of diabetic vascular complications. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939231&form=6&db=m Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-alpha. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14757134&form=6&db=m Protein kinase C-beta inhibition and diabetic microangiopathy: effects on endothelial permeability responses in vitro. unassigned - 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15384959&form=6&db=m Polymorphisms in the 5'-upstream region of the PKCbeta gene in Japanese patients with Type 2 diabetes. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15999697&form=6&db=m [Progress on the drug therapy for diabetic microangiopathies: PKCbeta inhibitor] causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16022668&form=6&db=m Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026268&form=6&db=m NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16222610&form=6&db=m Pathophysiological role of Amadori-glycated proteins in diabetic microangiopathy. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16578848&form=6&db=m Activation of protein kinase C by elevation of glucose concentration: Proposal for a mechanism in the development of diabetic vascular complications. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160912&form=6&db=m Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17472415&form=6&db=m Ruboxistaurin: LY 333531. therapeutic application,unassigned 4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210748&form=6&db=m Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22313801&form=6&db=m Inhibition of Protein Kinase C ? Ameliorates Impaired Angiogenesis in Type I Diabetic Mice Complicating Myocardial Infarction. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29297254&form=6&db=m Amelioration of diabetic nephropathy by oral administration of d-?-tocopherol and its mechanisms. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1530628&form=6&db=m Protein kinase C activity is altered in diabetic rat hearts. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458880&form=6&db=m Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630371&form=6&db=m Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930726&form=6&db=m Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343639&form=6&db=m Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19153662&form=6&db=m Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19882101&form=6&db=m Breviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca(2+)-cycling proteins in streptozotocin-induced diabetic rats. therapeutic application,unassigned 1,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21179305&form=6&db=m Coronary microvascular dysfunction in diabetes mellitus: A review. unassigned - 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22564708&form=6&db=m Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: Possible involvement of PKC-MAPK signaling pathway. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22727642&form=6&db=m Identification of specific features of inhibition of PKC?II and its potential lead by shape-based virtual screening and molecular docking studies. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23456446&form=6&db=m Role of microangiopathy in diabetic cardiomyopathy. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23474486&form=6&db=m Hyperglycemia-induced PKC?2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713345&form=6&db=m Protein Kinases as Drug Development Targets for Heart Disease Therapy. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8573737&form=6&db=m Protein kinase C in diabetic nephropathy. therapeutic application,unassigned 2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9133554&form=6&db=m Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9568702&form=6&db=m Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572571&form=6&db=m A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9609459&form=6&db=m A high glucose concentration stimulates the expression of monocyte chemotactic peptide 1 in human mesangial cells. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10588367&form=6&db=m Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10789192&form=6&db=m [The role of cellular glucose transporters in pathogenesis of diabetic nephropathy] causal interaction,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11168949&form=6&db=m Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576956&form=6&db=m Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714094&form=6&db=m Novel approaches to the treatment of progressive renal disease. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11784718&form=6&db=m High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11997313&form=6&db=m Mesangial cell protein kinase C isozyme activation in the diabetic milieu. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12540629&form=6&db=m Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12612945&form=6&db=m Progression of diabetic nephropathy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660493&form=6&db=m High glucose induces type 1 hexokinase gene expression in isolated glomeruli of diabetic rats and in mesangial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12739026&form=6&db=m In situ protein Kinase C activity is increased in cultured fibroblasts from Type 1 diabetic patients with nephropathy. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12955673&form=6&db=m A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14514644&form=6&db=m Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277392&form=6&db=m Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15318096&form=6&db=m ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327405&form=6&db=m High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15500138&form=6&db=m [Nephrotic syndrome due to metabolic disease--special reference to diabetic nephropathy] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15504973&form=6&db=m Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15787672&form=6&db=m Increased renal glucose metabolism in Type 1 diabetes mellitus. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16955103&form=6&db=m Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17259378&form=6&db=m Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17327498&form=6&db=m Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose. causal interaction,unassigned 2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17357479&form=6&db=m Different expressions of protein kinase C-alpha, betaI and betaII in glomeruli of diabetic nephropathy patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17506942&form=6&db=m Effect of telmisartan on expression of protein kinase C-alpha in kidneys of diabetic mice. ongoing research,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584148&form=6&db=m Novel therapeutic targets for diabetic nephropathy. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653211&form=6&db=m The role of protein kinase C activation in diabetic nephropathy. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691932&form=6&db=m Molecular mechanisms of diabetic nephropathy and its therapeutic intervention. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693752&form=6&db=m Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17694297&form=6&db=m GLUT2 protein at the rat proximal tubule brush border membrane correlates with protein kinase C (PKC)-betal and plasma glucose concentration. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699475&form=6&db=m Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17923043&form=6&db=m [Protein kinase C-betaI, betaII in mouse diabetic nephropathy kidney and its relation to nephroprotective actions of the angiotensin receptor blocker telmistartan] diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17959934&form=6&db=m Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18278479&form=6&db=m Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485142&form=6&db=m Protein kinase C beta inhibitors: a new therapeutic target for diabetic nephropathy and vascular complications. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18937679&form=6&db=m No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C>T and c.-546C>G with diabetic nephropathy in Type 1 diabetes. unassigned - 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19155535&form=6&db=m Protein kinase C-{beta} inhibition attenuates the progression of nephropathy in non-diabetic kidney disease. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19275608&form=6&db=m Therapeutic strategies in the treatment of diabetic nephropathy - a translational medicine approach. unassigned - 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20141354&form=6&db=m Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20419132&form=6&db=m Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20665664&form=6&db=m Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21321125&form=6&db=m PKC{alpha} Mediates {beta}-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575103&form=6&db=m Protein kinase C ß inhibition ameliorates experimental mesangial proliferative glomerulonephritis. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22010346&form=6&db=m [Effect of tangshen formula on phospholipids metabolism in diabetic nephropathy patients]. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23434935&form=6&db=m Dual Inhibition of Classical Protein Kinase C-? and Protein Kinase C-? Isoforms Protects Against Experimental Murine Diabetic Nephropathy. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25414693&form=6&db=m Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701431&form=6&db=m NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early-stage diabetic kidney. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26823823&form=6&db=m Influence of protein kinase C (PKC) on the prognosis of diabetic nephropathy patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28572624&form=6&db=m Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28785561&form=6&db=m Sodium-Glucose Cotransporter 2 Inhibitors with Renoprotective Effects. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29297254&form=6&db=m Amelioration of diabetic nephropathy by oral administration of d-?-tocopherol and its mechanisms. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31919106&form=6&db=m Whole-Genome Sequencing of Finnish Type 1 Diabetic Siblings Discordant for Kidney Disease Reveals DNA Variants associated with Diabetic Nephropathy. therapeutic application,unassigned 1,0 2.7.11.13 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32678222&form=6&db=m The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase ?. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659349&form=6&db=m Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes. unassigned - 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034118&form=6&db=m Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and (Na,K)-ATPase regulation in diabetic neuropathy. unassigned - 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9134970&form=6&db=m Protein kinase C isozyme expression in sciatic nerves and spinal cords of experimentally diabetic rats. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10447525&form=6&db=m Protein kinase C effects on nerve function, perfusion, Na(+), K(+)-ATPase activity and glutathione content in diabetic rats. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12193157&form=6&db=m Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12673781&form=6&db=m Polyol pathway and protein kinase C activity of rat Schwannoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887697&form=6&db=m Diabetic neuropathy: inhibitory G protein dysfunction involves PKC-dependent phosphorylation of Goalpha. therapeutic application,unassigned 1,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954365&form=6&db=m Protein kinase C beta inhibition and aorta and corpus cavernosum function in streptozotocin-diabetic mice. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14750401&form=6&db=m Diabetic neuropathy: an intensive review. causal interaction,unassigned 1,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220622&form=6&db=m Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential component. unassigned - 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18579738&form=6&db=m Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20425233&form=6&db=m Therapeutic strategies for diabetic neuropathy. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20795891&form=6&db=m Emerging drugs for diabetic neuropathy. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21128935&form=6&db=m Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats. ongoing research,unassigned 4,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22846968&form=6&db=m Role of Oxidative Stress and Ca(2+) Signaling on Molecular Pathways of Neuropathic Pain in Diabetes: Focus on TRP Channels. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24373831&form=6&db=m Diabetic peripheral neuropathy: current perspective and future directions. causal interaction,unassigned 1,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502583&form=6&db=m A Comprehensive Review of Erectile Dysfunction in Men with Diabetes. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27341846&form=6&db=m Diabetic Neuropathy: Update on Pathophysiological Mechanism and the Possible Involvement of Glutamate Pathways. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27721335&form=6&db=m Real-Time Translocation and Function of PKC?II Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor. causal interaction,unassigned 2,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021390&form=6&db=m Erythropoietin: A potential drug in the management of diabetic neuropathy. causal interaction,unassigned 1,0 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31760655&form=6&db=m Schwann Cells as Crucial Players in Diabetic Neuropathy. unassigned - 2.7.11.13 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292149&form=6&db=m Deciphering the Neuroprotective Role of Glucagon-like Peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10512378&form=6&db=m A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11672473&form=6&db=m Increased platelet aggregation in diabetic patients with microangiopathy despite good glycemic control. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11903393&form=6&db=m Protein kinase C and the development of diabetic vascular complications. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992868&form=6&db=m Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126787&form=6&db=m Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12494366&form=6&db=m [The role of protein kinase C in the pathophysiology of diabetic retinopathy] causal interaction,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507629&form=6&db=m Mechanisms for monitoring changes in retinal status following therapeutic intervention in diabetic retinopathy. therapeutic application,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12765965&form=6&db=m Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy. causal interaction,unassigned 1,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789620&form=6&db=m Ruboxistaurin (Eli Lilly). causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693793&form=6&db=m Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research. therapeutic application,unassigned 1,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14737743&form=6&db=m The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14762400&form=6&db=m Growth factors and protein kinase C inhibitors as novel therapies for the medical management diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15193366&form=6&db=m Inhibition of protein kinase C might be harmful to diabetic retinopathy. therapeutic application,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778843&form=6&db=m Protein kinase C expression in the rabbit retina after laser photocoagulation. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15934878&form=6&db=m Current and future pharmacological intervention for diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15983221&form=6&db=m The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080914&form=6&db=m Role of protein kinase C on the alteration of retinal endothelin-1 in streptozotocin-induced diabetic rats. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16200860&form=6&db=m [The changes of histology and biochemical parameters in retina of the patient with diabetic retinopathy] diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16504599&form=6&db=m Diabetes: assessing the pipeline. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17028667&form=6&db=m Ruboxistaurin. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17245085&form=6&db=m Treatment of diabetic retinopathy with protein kinase C subtype Beta inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17277392&form=6&db=m Update on the treatment of diabetic retinopathy. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380065&form=6&db=m Pharmacological treatment of diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17472415&form=6&db=m Ruboxistaurin: LY 333531. therapeutic application,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17522264&form=6&db=m Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17628122&form=6&db=m Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema. therapeutic application,unassigned 1,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720893&form=6&db=m Screening for and managing diabetic retinopathy: current approaches. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17967707&form=6&db=m Endothelin-1 and protein kinase C co-expression in the pathogenesis of diabetic retinopathy. unassigned - 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18028012&form=6&db=m Targeting the retinal microcirculation to treat diabetic sight problems. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408491&form=6&db=m Update on treatments for diabetic macular edema. therapeutic application,unassigned 1,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508951&form=6&db=m Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19380207&form=6&db=m Specific medical intervention for diabetic retinopathy. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19817721&form=6&db=m Diabetic macular oedema and visual loss: relationship to location, severity and duration. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19881493&form=6&db=m Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. unassigned - 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110406&form=6&db=m Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20141354&form=6&db=m Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939796&form=6&db=m Protein Kinase C Inhibitors in the Treatment of Diabetic Retinopathy. Review. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939801&form=6&db=m Aldose Reductase / Polyol Inhibitors For Diabetic Retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21386766&form=6&db=m EFFECT OF RUBOXISTAURIN (RBX) ON VISUAL ACUITY DECLINE OVER A 6-YEAR PERIOD WITH CESSATION AND REINSTITUTION OF THERAPY: Results of an Open-Label Extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2). ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21416789&form=6&db=m Diabetic retinopathy: current developments in pathogenesis and management. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862954&form=6&db=m ORAL PROTEIN KINASE C ? INHIBITION USING RUBOXISTAURIN: Efficacy, Safety, and Causes of Vision Loss Among 813 Patients (1,392 Eyes) with Diabetic Retinopathy in the Protein Kinase C ? Inhibitor-Diabetic Retinopathy Study and the Protein kinase C ? Inhibitor-Diabetic Retinopathy Study 2. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24434146&form=6&db=m Suppression of protein kinase C-? attenuates vascular leakage via prevention of tight junction protein decrease in diabetic retinopathy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24497733&form=6&db=m Computational investigation of pkc? inhibitors for the treatment of diabetic retinopathy. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631337&form=6&db=m Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C ? in a mouse model of diabetic retinopathy. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26015772&form=6&db=m IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27939241&form=6&db=m The anti-ALS drug riluzole attenuates pericyte loss in the diabetic retinopathy of streptozotocin-treated mice. causal interaction,unassigned 4,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30254714&form=6&db=m The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy. therapeutic application,unassigned 1,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30551523&form=6&db=m A non-invasive, multi-target approach to treat diabetic retinopathy. causal interaction,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31743046&form=6&db=m Relationship between aldose reductase enzyme and the signaling pathway of protein kinase C in the in vitro diabetic retinopathy model. ongoing research,unassigned 3,0 2.7.11.13 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32065092&form=6&db=m Potential Biomarkers in Diabetic Retinopathy. therapeutic application,unassigned 1,0 2.7.11.13 Diphtheria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17915215&form=6&db=m Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I. therapeutic application,unassigned 2,0 2.7.11.13 Distemper http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9185603&form=6&db=m Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Donohue Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2808704&form=6&db=m Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8857747&form=6&db=m Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14563691&form=6&db=m Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating tau protein Ser phosphorylation. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502583&form=6&db=m A Comprehensive Review of Erectile Dysfunction in Men with Diabetes. causal interaction,unassigned 4,0 2.7.11.13 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505044&form=6&db=m Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. unassigned - 2.7.11.13 Duodenal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12220644&form=6&db=m Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Dysarthria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17149711&form=6&db=m Spinocerebellar ataxia 14: novel mutation in exon 2 of PRKCG in a German family. causal interaction,unassigned 3,0 2.7.11.13 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16894036&form=6&db=m Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. causal interaction,unassigned 4,0 2.7.11.13 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502583&form=6&db=m A Comprehensive Review of Erectile Dysfunction in Men with Diabetes. causal interaction,unassigned 4,0 2.7.11.13 Echovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23824807&form=6&db=m Cell susceptibility to baculovirus transduction and echovirus infection is modified by protein kinase C phosphorylation and vimentin organization. ongoing research,unassigned 1,0 2.7.11.13 Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9597760&form=6&db=m Platelets from eclampsia patients have reduced membrane microviscosity and lower activities of the signalling enzymes. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16493044&form=6&db=m Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase C{theta}-Deficient Mice. ongoing research,unassigned 4,0 2.7.11.13 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16729719&form=6&db=m PKCtheta: A potential therapeutic target for T-cell-mediated diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23385082&form=6&db=m Protein kinase C gamma (PKC?) as a novel marker to assess the functional status of the corticospinal tract in experimental autoimmune encephalomyelitis (EAE). diagnostic usage,ongoing research,unassigned 2,1,0 2.7.11.13 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16493044&form=6&db=m Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase C{theta}-Deficient Mice. ongoing research,unassigned 4,0 2.7.11.13 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16729719&form=6&db=m PKCtheta: A potential therapeutic target for T-cell-mediated diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23385082&form=6&db=m Protein kinase C gamma (PKC?) as a novel marker to assess the functional status of the corticospinal tract in experimental autoimmune encephalomyelitis (EAE). diagnostic usage,ongoing research,unassigned 2,1,0 2.7.11.13 Encephalomyelitis, Venezuelan Equine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32150585&form=6&db=m Protein Kinase C subtype ? interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280205&form=6&db=m Phorbol esters differentially regulate the expression of insulin-like growth factor-binding proteins in endometrial carcinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7641741&form=6&db=m Clinical implication of fos and jun expressions and protein kinase activity in endometrial cancers. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7734622&form=6&db=m cAMP and PMA enhance the effects of IGF-I in the proliferation of endometrial adenocarcinoma cell line HEC-1-A by acting at the G1 phase of the cell cycle. ongoing research,unassigned 4,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8126384&form=6&db=m [Effect of phorbol ester on tissue-type plasminogen activator (t-PA) secretion in endometrial carcinoma cell line in vitro] causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8701784&form=6&db=m Estrogen induces expression of c-fos and c-jun via activation of protein kinase C in an endometrial cancer cell line and fibroblasts derived from human uterine endometrium. ongoing research,unassigned 3,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9345355&form=6&db=m Epidermal growth factor activates protein kinase C in the human endometrial cancer cell line HEC-1-A. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11371124&form=6&db=m Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11720885&form=6&db=m Protein kinase C-independent stimulation of activator protein-1 and c-Jun N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17158769&form=6&db=m Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17959229&form=6&db=m Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467439&form=6&db=m X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor alpha-induced apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18534651&form=6&db=m Membrane ERalpha-dependent activation of PKCalpha in endometrial cancer cells by estradiol. therapeutic application,unassigned 1,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235902&form=6&db=m Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424800&form=6&db=m c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672862&form=6&db=m Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21541621&form=6&db=m Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines. causal interaction,unassigned 1,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21618512&form=6&db=m Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. unassigned - 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23843797&form=6&db=m Protein Kinase C ? Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells. causal interaction,unassigned 4,0 2.7.11.13 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.7.11.13 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299092&form=6&db=m DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16815388&form=6&db=m Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17481625&form=6&db=m Effects of a protein kinase C inhibitor on the initial development of ectopic implants in a syngeneic mouse model of endometriosis. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118114&form=6&db=m Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.11.13 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2780715&form=6&db=m Modification of protein kinase C (PKC) activity and diacylglycerol (DAG) accumulation in hepatocytes in continuous endotoxemia. unassigned - 2.7.11.13 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2928368&form=6&db=m Alterations in splenic and hepatic protein kinase C in sepsis and chronic endotoxemia. unassigned - 2.7.11.13 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8222001&form=6&db=m [Alterations of protein kinase C activity in rat myocardium and aorta smooth muscle during endotoxemia] ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22393041&form=6&db=m Protein kinase C delta (PKC?)-extracellular-signal regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. therapeutic application,unassigned 4,0 2.7.11.13 Enzootic Bovine Leukosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318412&form=6&db=m Inhibition of protein kinase C results in decreased expression of bovine leukemia virus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Epilepsies, Partial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1884207&form=6&db=m Protein kinase C activity and intracellular distribution in surgically excised human epileptic neocortex. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10526339&form=6&db=m Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306123&form=6&db=m Differential expression of atypical PKCs in the adult mouse brain. unassigned - 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16533575&form=6&db=m Role of protein kinase C in modulation of excitability of CA1 pyramidal neurons in the rat. ongoing research,unassigned 2,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17182870&form=6&db=m Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. causal interaction,unassigned 2,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22275068&form=6&db=m The binding affinities of proteins interacting with the PDZ domain of PICK1. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23436724&form=6&db=m Protein interacting with C kinase and neurological disorders. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970394&form=6&db=m Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888867&form=6&db=m PICK1facilitates lasting reduction in GluA2 concentration In the hippocampus during chronic epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31572289&form=6&db=m FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats. unassigned - 2.7.11.13 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617826&form=6&db=m A hydrogen sulfide donor suppresses pentylenetetrazol-induced seizures in rats via PKC signaling. causal interaction,unassigned 2,0 2.7.11.13 Epilepsy, Absence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18641645&form=6&db=m PICK1 uncoupling from mGluR7a causes absence-like seizures. ongoing research,unassigned 1,0 2.7.11.13 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383238&form=6&db=m Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. unassigned - 2.7.11.13 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27063964&form=6&db=m Cordycepin enhances Epstein-Barr virus lytic infection and Epstein-Barr virus-positive tumor treatment efficacy by doxorubicin. therapeutic application,unassigned 1,0 2.7.11.13 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33047643&form=6&db=m Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: First Case from the National Iranian Registry and Review of the Literature. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16888082&form=6&db=m Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17367430&form=6&db=m Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat. ongoing research,unassigned 1,0 2.7.11.13 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7727278&form=6&db=m Attenuation of ultraviolet radiation-induced edema and erythema with topical calmodulin and protein kinase C inhibitors. therapeutic application,unassigned 3,0 2.7.11.13 Escherichia coli Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15578063&form=6&db=m Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632825&form=6&db=m Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18270704&form=6&db=m Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21595773&form=6&db=m Phorbol 12,13 dibutyrate behaves in a tumor-inhibitory manner in esophageal adenocarcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481515&form=6&db=m PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9227490&form=6&db=m Experimental esophagitis affects intracellular calcium stores in the cat lower esophageal sphincter. ongoing research,unassigned 1,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336404&form=6&db=m The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165267&form=6&db=m Protein kinase C activity in erythrocytes in primary hypertension: regulation of cell shape and cation transport. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3169942&form=6&db=m Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3235834&form=6&db=m Activity of protein kinase C in erythrocytes in primary hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3411869&form=6&db=m [Protein kinase A and C activity of erythrocytes in patients with essential hypertension] causal interaction,unassigned 4,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179856&form=6&db=m Cytosolic Ca2+, Na+/H+ antiport, protein kinase C trio in essential hypertension. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9225570&form=6&db=m [Red cell Na+/H+ exchange and role of protein kinase C in its stimulation in diabetes mellitus, essential hypertension and nephropathy] causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23753411&form=6&db=m Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32327351&form=6&db=m Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema. therapeutic application,unassigned 4,0 2.7.11.13 Fasciculation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589384&form=6&db=m Defasciculation of neurites is mediated by tenascin-R and its neuronal receptor F3/11. therapeutic application,unassigned 1,0 2.7.11.13 Fasciculation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9971736&form=6&db=m Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. ongoing research,unassigned 2,0 2.7.11.13 Fasciculation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11856312&form=6&db=m NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Fasciculation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14697253&form=6&db=m Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. unassigned - 2.7.11.13 Fasciculation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19437419&form=6&db=m Ectopic growth of hippocampal mossy fibers in a mutated GAP-43 transgenic mouse with impaired spatial memory retention. ongoing research,unassigned 2,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2802319&form=6&db=m Decreased protein kinase C activity in fatty liver from cattle. ongoing research,unassigned 3,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7645429&form=6&db=m Choline and hepatocarcinogenesis in the rat. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7701779&form=6&db=m Reduced protein kinase C activity and endogenous protein phosphorylation in ethionine-induced fatty liver in cows. therapeutic application,unassigned 1,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8420980&form=6&db=m Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15166226&form=6&db=m Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. therapeutic application,unassigned 2,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963478&form=6&db=m Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency. causal interaction,unassigned 1,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022218&form=6&db=m PKCepsilon plays a causal role in acute ethanol-induced steatosis. therapeutic application,unassigned 1,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19413892&form=6&db=m Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain. therapeutic application,unassigned 1,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20569275&form=6&db=m Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20971848&form=6&db=m Protein kinase C (PKC) delta is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death. unassigned - 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464441&form=6&db=m Ablation of PI3K p110-{alpha} Prevents High-Fat Diet-Induced Liver Steatosis. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24454937&form=6&db=m Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis. ongoing research,unassigned 2,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26192243&form=6&db=m [Mechanism of expression of the Src family kinases (Fgr, Hck, Lyn) and SSeCKS in non-alcoholic steatohepatitis]. ongoing research,unassigned 2,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150932&form=6&db=m High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4? and leads to hepatic steatosis in mice. causal interaction,unassigned 1,0 2.7.11.13 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30049588&form=6&db=m The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome. causal interaction,unassigned 1,0 2.7.11.13 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057900&form=6&db=m Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196474&form=6&db=m Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. unassigned - 2.7.11.13 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210758&form=6&db=m N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. causal interaction,unassigned 3,0 2.7.11.13 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18497343&form=6&db=m Demonstration of the essential role of protein kinase C isoforms in hyperglycemia-induced embryonic malformations. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21376163&form=6&db=m Protein kinase C?2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway. unassigned - 2.7.11.13 Fetal Hypoxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20538683&form=6&db=m Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts. causal interaction,unassigned 4,0 2.7.11.13 Fetal Nutrition Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34486775&form=6&db=m Fetal malnutrition is associated with impairment of endogenous melatonin synthesis in pineal via hypermethylation of promoters of protein kinase C alpha and cAMP response element-binding. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974259&form=6&db=m Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Fibromyalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1676263&form=6&db=m Altered interleukin-2 secretion in patients with primary fibromyalgia syndrome. causal interaction,unassigned 4,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1855195&form=6&db=m Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1874600&form=6&db=m A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1881450&form=6&db=m Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts. ongoing research,unassigned 4,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2061000&form=6&db=m Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2253220&form=6&db=m Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin. unassigned - 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2601739&form=6&db=m A mutant protein kinase C that can transform fibroblasts. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2707442&form=6&db=m Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621660&form=6&db=m The eta isoform of protein kinase C mediates transcriptional activation of the human transglutaminase 1 gene. causal interaction,unassigned 1,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9392558&form=6&db=m The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756852&form=6&db=m Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873009&form=6&db=m Phospholipase D mediates matrix metalloproteinase-9 secretion in phorbol ester-stimulated human fibrosarcoma cells. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11004668&form=6&db=m Protein kinase C isoforms involved in regulation of cell shape and locomotion of human fibrosarcoma HT1080 cells. ongoing research,unassigned 3,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245008&form=6&db=m [An experimental study on the capability of laminin receptor antibody and protein kinase C inhibitor to inhibit tumor metastasis in vivo] causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566819&form=6&db=m Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446057&form=6&db=m Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25601862&form=6&db=m Systems Biology Strategy Reveals PKC? is Key for Sensitizing TRAIL-Resistant Human Fibrosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28529490&form=6&db=m Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes. unassigned - 2.7.11.13 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31768670&form=6&db=m Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease. therapeutic application,unassigned 1,0 2.7.11.13 Frontotemporal Lobar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20886841&form=6&db=m Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration. therapeutic application,unassigned 1,0 2.7.11.13 Frontotemporal Lobar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30999060&form=6&db=m The olfactory bulb proteotype differs across frontotemporal dementia spectrum. causal interaction,unassigned 1,0 2.7.11.13 Gait Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17149711&form=6&db=m Spinocerebellar ataxia 14: novel mutation in exon 2 of PRKCG in a German family. causal interaction,unassigned 3,0 2.7.11.13 Galactosemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9519755&form=6&db=m Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16194684&form=6&db=m Protein kinase C-alpha regulation of gallbladder Na+ transport becomes progressively more dysfunctional during gallstone formation. unassigned - 2.7.11.13 Ganglioglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18819986&form=6&db=m Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. diagnostic usage,unassigned 2,0 2.7.11.13 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8197871&form=6&db=m Protein kinase C activation in Aplysia neurons by phorbol diacetate: comparison of effects following extracellular or intracellular application. ongoing research,unassigned 3,0 2.7.11.13 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30360692&form=6&db=m Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31705725&form=6&db=m Activation of the RAS/B-RAF-MEK-ERK pathway in satellite glial cells contributes to substance p-mediated orofacial pain. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Gangliosidoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904996&form=6&db=m Phorbol ester receptors in cerebral cortex of cats with GM1 gangliosidosis. unassigned - 2.7.11.13 Gardner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974259&form=6&db=m Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2775273&form=6&db=m Levels of protein kinase C activity in human gastrointestinal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9442092&form=6&db=m Dihydroxy bile acids activate the transcription of cyclooxygenase-2. ongoing research,unassigned 4,0 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217944&form=6&db=m Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289315&form=6&db=m Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs). causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743318&form=6&db=m PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892012&form=6&db=m PKCtheta expression in gastrointestinal stromal tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381383&form=6&db=m Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716167&form=6&db=m Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20948918&form=6&db=m Clinicopathological and immunohistochemical features of gastointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21685034&form=6&db=m Gastrointestinal stromal tumor markers in cutaneous melanomas: relationship to prognostic factors and outcome. diagnostic usage,unassigned 3,0 2.7.11.13 Gaucher Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3101176&form=6&db=m Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19365031&form=6&db=m Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Gestational Trophoblastic Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24051221&form=6&db=m p-21-Activated kinase-1, -4 and -6 and estrogen receptor expression pattern in normal placenta and gestational trophoblastic diseases. causal interaction,unassigned 2,0 2.7.11.13 Giant Cell Tumor of Bone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8554927&form=6&db=m Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone. ongoing research,unassigned 4,0 2.7.11.13 Giant Cell Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8554927&form=6&db=m Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone. ongoing research,unassigned 4,0 2.7.11.13 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16547586&form=6&db=m The role of PKCzeta in NMDA-induced retinal ganglion cell death: prevention by aspirin. causal interaction,unassigned 4,0 2.7.11.13 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390643&form=6&db=m Alpha-tocopherol: looking beyond an antioxidant. unassigned - 2.7.11.13 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33375386&form=6&db=m Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316231&form=6&db=m Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335968&form=6&db=m Protein kinase C isoforms in human glioblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2655888&form=6&db=m Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor beta 1. unassigned - 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6297726&form=6&db=m Multiple forms of protein kinase from normal human brain and glioblastoma. ongoing research,unassigned 3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7832755&form=6&db=m Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes. ongoing research,unassigned 4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7838340&form=6&db=m Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931620&form=6&db=m The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700129&form=6&db=m Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9473348&form=6&db=m Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9634008&form=6&db=m Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816263&form=6&db=m Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter. therapeutic application,unassigned 1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927633&form=6&db=m Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10068276&form=6&db=m Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336429&form=6&db=m Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402232&form=6&db=m Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10505046&form=6&db=m Tamoxifen inhibits particulate-associated protein kinase C activity, and sensitises cultured human glioblastoma cells not to etoposide but to gamma-radiation and BCNU. ongoing research,unassigned 4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10628339&form=6&db=m The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10963898&form=6&db=m Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979985&form=6&db=m Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells ongoing research,unassigned 4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10982151&form=6&db=m Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11092528&form=6&db=m The endothelin system in human glioblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772428&form=6&db=m Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014630&form=6&db=m Induction of apoptosis in glioblastoma cells by an atypical protein kinase C pseudosubstrate peptide. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269829&form=6&db=m Modulation of the human protein kinase C alpha gene promoter by activator protein-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657722&form=6&db=m Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719093&form=6&db=m The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review). causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15153340&form=6&db=m CREB regulates AChE-R-induced proliferation of human glioblastoma cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15489897&form=6&db=m PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways. ongoing research,unassigned 3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604283&form=6&db=m The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15618223&form=6&db=m Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701280&form=6&db=m Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15780200&form=6&db=m Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15934917&form=6&db=m PKCeta as a therapeutic target in glioblastoma multiforme. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331246&form=6&db=m Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Ciota-mediated attenuation of p38 MAP kinase signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16600621&form=6&db=m Rehmannia glutinosa induces glial cell line-derived neurotrophic factor gene expression in astroglial cells via cPKC and ERK1/2 pathways independently. ongoing research,unassigned 1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16763818&form=6&db=m Influence of Pi3-K and PKC activity on 99mTc-(V)-DMSA uptake: correlation with tumour aggressiveness in an in vitro malignant glioblastoma cell line model. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146445&form=6&db=m The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway. ongoing research,unassigned 3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640620&form=6&db=m Phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells is mediated via p38MAPK/Hsp27 pathway. ongoing research,unassigned 4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786281&form=6&db=m Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17827463&form=6&db=m Chemoradiotherapy in malignant glioma: standard of care and future directions. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18212741&form=6&db=m Regulation of glioblastoma cell invasion by PKC iota and RhoB. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508315&form=6&db=m PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18813807&form=6&db=m Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastoma cells via paxillin. unassigned - 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18947333&form=6&db=m Galectin-1 Is Implicated in the Protein Kinase C epsilon/Vimentin-Controlled Trafficking of Integrin-beta1 in Glioblastoma Cells. unassigned - 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19187446&form=6&db=m Reduction of protein kinase C zeta inhibits migration and invasion of human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19223491&form=6&db=m Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19357285&form=6&db=m ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration. ongoing research,unassigned 1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20167819&form=6&db=m Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20669099&form=6&db=m PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21727210&form=6&db=m Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation. causal interaction,unassigned 3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22021906&form=6&db=m Regulation of Cdk7 activity through a phosphatidylinositol (3)-kinase/PKC-?-mediated signaling cascade in glioblastoma. ongoing research,unassigned 3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22215664&form=6&db=m Acridine Yellow G Blocks Glioblastoma Growth via Dual Inhibition of Epidermal Growth Factor Receptor and Protein Kinase C Kinases. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23907540&form=6&db=m PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118327&form=6&db=m Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF? in glioblastoma. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26208522&form=6&db=m PKC? depletion initiates mitotic slippage-induced senescence in glioblastoma. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26490262&form=6&db=m Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression. ongoing research,unassigned 2,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26943907&form=6&db=m The Curcumin Analog C-150, Influencing NF-?B, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo. therapeutic application,unassigned 1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27299852&form=6&db=m Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29642372&form=6&db=m ?-3 and ?-6 Fatty Acids Modulate Conventional and Atypical Protein Kinase C Activities in a Brain Fatty Acid Binding Protein Dependent Manner in Glioblastoma Multiforme. causal interaction,unassigned 1,0 2.7.11.13 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33916593&form=6&db=m Targeting Protein Kinase C in Glioblastoma Treatment. therapeutic application,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324669&form=6&db=m Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331757&form=6&db=m Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332804&form=6&db=m Insulin-like growth factor I modulates voltage-dependent Ca2+ channels in neuronal cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1362254&form=6&db=m Activation of phospholipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: possible role in mitogenic signal transduction. ongoing research,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1407458&form=6&db=m Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1407459&form=6&db=m Enhancement of radiosensitivity by tamoxifen in C6 glioma cells. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1562992&form=6&db=m The role of protein kinase C in migration of rat glioma cells from spheroid cultures. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1758601&form=6&db=m Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2002388&form=6&db=m Glioma growth and the protein kinase-C system. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2023931&form=6&db=m Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157030&form=6&db=m Regulation of cAMP levels by protein kinase C in C6 rat glioma cells. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161913&form=6&db=m Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2224848&form=6&db=m Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2302562&form=6&db=m Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+. therapeutic application,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2398390&form=6&db=m Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505261&form=6&db=m Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2789336&form=6&db=m A major myristylated substrate of protein kinase C and protein kinase C itself are differentially regulated during murine B- and T-lymphocyte development and activation. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2912965&form=6&db=m Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034259&form=6&db=m Down-regulation of protein kinase C in rat glioma C6 cells: effects on the beta-adrenergic receptor-coupled adenylate cyclase. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034276&form=6&db=m Concanavalin A prevents phorbol-mediated redistribution of protein kinase C and beta-adrenergic receptors in rat glioma C6 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6244301&form=6&db=m Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7490614&form=6&db=m Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7492943&form=6&db=m Differential expression of protein kinase C isoforms in glial and neuronal cells. Translocation and down-regulation of PKC isoforms in C6 glioma and NG 108-15 hybrid cells: effects of extracellular Ca(2+)-depletion. ongoing research,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7538636&form=6&db=m Effects of protein kinase C modulators on multidrug resistance in human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7556638&form=6&db=m Protein expression of the alpha, gamma, delta and epsilon subspecies of protein kinase C changes as C6 glioma cells become contact inhibited and quiescent in the presence of serum. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7577661&form=6&db=m The efficacy of tamoxifen as an antiproliferative agent in vitro for benign and malignant pediatric glial tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7595754&form=6&db=m Protein kinase C isoform alpha overexpression in C6 glioma cells and its role in cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7614929&form=6&db=m High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7621533&form=6&db=m Changes in Ca2+ concentration in phorbol ester and thapsigargin treated glioma C6 cells. The role of protein kinase C in regulation of Ca2+ entry. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7758843&form=6&db=m Transcriptional regulation of the lactate dehydrogenase A subunit gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7830075&form=6&db=m Differential correlation between translocation and down-regulation of conventional and new protein kinase C isozymes in C6 glioma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7861225&form=6&db=m Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomas. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7885569&form=6&db=m Protein kinase C and growth regulation in malignant gliomas. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964753&form=6&db=m Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells. ongoing research,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999012&form=6&db=m Heterogeneity of protein kinase C activity in human U-373 and G-26 mice glioma cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020472&form=6&db=m Differential nuclear localization of protein kinase C isoforms in neuroblastoma x glioma hybrid cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8026577&form=6&db=m Effects of Ca2+ on the activation of conventional and new PKC isozymes and on TPA and endothelin-1 induced translocations of these isozymes in intact cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106570&form=6&db=m Transition metal chelator TPEN counteracts phorbol ester-induced actin cytoskeletal disruption in C6 rat glioma cells without inhibiting activation or translocation of protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8131935&form=6&db=m Protein kinase C activation of phospholipase D in C6 glioma cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8131958&form=6&db=m Staurosporine and its derivative RO31-8220, both inhibitors of protein kinase C, have different effects on C6 glioma cell morphology. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8194597&form=6&db=m Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8198596&form=6&db=m Opposite effects of the overexpression of protein kinase C gamma and delta on the growth properties of human glioma cell line U251 MG. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8239502&form=6&db=m Differential effects of 12-O-tetradecanoyl-13-phorbol acetate (TPA) on growth, migration and invasion of a human glioma cell line. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245986&form=6&db=m Inhibition of beta-amyloid production by activation of protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8264555&form=6&db=m P2U-purinergic receptors on C6-2B rat glioma cells: modulation of cytosolic Ca2+ and cAMP levels by protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8289091&form=6&db=m Staurosporine differentially inhibits glioma versus non-glioma cell lines. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8320719&form=6&db=m Whole-cell recording of neuroblastoma x glioma cells during downregulation of a major substrate, 80K/MARCKS, of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383803&form=6&db=m Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384328&form=6&db=m Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen. diagnostic usage,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396484&form=6&db=m Agonist-induced desensitization of ATP receptor-mediated phosphoinositide turnover in C6 glioma cells: comparison with the negative-feedback regulation by protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8405436&form=6&db=m Protein kinase C alpha, delta, epsilon and zeta in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta. diagnostic usage,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8413883&form=6&db=m Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8455032&form=6&db=m Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8455059&form=6&db=m Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8477817&form=6&db=m Endothelin receptors stimulate both phospholipase C and phospholipase D activities in different cell lines. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8562473&form=6&db=m In situ effects of interferon on human glioma protein kinase C-alpha and -beta ultrastructural localization. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8587660&form=6&db=m Cholecystokinin induced signaling in rat glioma C6 cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8599768&form=6&db=m Protein kinase C and growth regulation of malignant gliomas. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615806&form=6&db=m Phosphorylation of membrane proteins in erythrocytes treated with lead. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8684595&form=6&db=m Characterization of taurine transport in human glioma GL15 cell line: regulation by protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8837815&form=6&db=m Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847567&form=6&db=m Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8848016&form=6&db=m Protein kinase C isoform delta is involved in the stimulation of the Na(+)-H+ exchanger in C6 glioma cells. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861817&form=6&db=m Model experiments on squid axons and NG108-15 mouse neuroblastoma x rat glioma hybrid cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8871536&form=6&db=m Glioma invasion in vitro: regulation by matrix metalloprotease-2 and protein kinase C. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8906563&form=6&db=m Protein kinase C isoforms and growth, differentiation and phosphatidylcholine turnover in human neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8915374&form=6&db=m High-affinity taurine uptake and its regulation by protein kinase C in human glioma cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8963653&form=6&db=m Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978498&form=6&db=m Signaling effects of alpha-thrombin and SFLLRN in rat glioma C6 cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9009219&form=6&db=m Protein expression of the epsilon subspecies of protein kinase C ceases as Swiss 3T6 fibroblasts increase in cell density even though message for the protein is still present. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9034963&form=6&db=m Phospholipase D hydrolysis of plasmalogen and diacyl ethanolamine phosphoglycerides by protein kinase C dependent and independent mechanisms. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9043741&form=6&db=m Mechanisms of glioma invasion: role of matrix-metalloproteinases. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049854&form=6&db=m The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9064647&form=6&db=m Activity of protein kinase C is necessary for sustained thrombin-induced [Ca2+]i oscillations in rat glioma cells. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113087&form=6&db=m Regulation of the functional activity of the human dopamine transporter by protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9232628&form=6&db=m Effects of interferon and PKC modulators on human glioma protein kinase C, cell proliferation, and cell cycle. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9245701&form=6&db=m Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9354938&form=6&db=m Effects of an inhibitor of protein kinases on the response to heat treatment in cultured mammalian cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395070&form=6&db=m Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9405236&form=6&db=m Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9442212&form=6&db=m The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9487144&form=6&db=m Involvement of phospholipase D and protein kinase C in phorbol ester and fatty acid stimulated turnover of phosphatidylcholine and phosphatidylethanolamine in neural cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9499434&form=6&db=m Differential role for protein kinase C-mediated signaling in the proliferation of medulloblastoma cell lines. causal interaction,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9506361&form=6&db=m Differential induction of cell death in human glioma cell lines by sodium nitroprusside. causal interaction,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9536517&form=6&db=m Effects of insulin on protein phosphorylation and protein kinase C activity in human malignant gliomas. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9570383&form=6&db=m Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9624687&form=6&db=m A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639259&form=6&db=m Protein kinase C is involved in cholecystokinin octapeptide-induced proliferative action in rat glioma C6 cells. ongoing research,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9658185&form=6&db=m Protein kinase C-mediated down-regulation of beta1-adrenergic receptor gene expression in rat C6 glioma cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9665591&form=6&db=m Apoptosis is induced in glioma cells by antisense oligonucleotides to protein kinase C alpha and is enhanced by cycloheximide. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9676858&form=6&db=m Disparity in expression of protein kinase C alpha in human glioma versus glioma-derived primary cell lines: therapeutic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9746294&form=6&db=m Tamoxifen modulation of carboplatin cytotoxicity in a human U-138 glioma cell line. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815790&form=6&db=m A phase I study of high-dose tamoxifen for the treatment of refractory malignant gliomas of childhood. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9990296&form=6&db=m Myristoylated alanine-rich C-kinase substrate is phosphorylated and translocated by a phorbol ester-insensitive and calcium-independent protein kinase C isoform in C6 glioma cell membranes. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10026138&form=6&db=m Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10049497&form=6&db=m Glutathione depletion induces giant DNA and high-molecular-weight DNA fragmentation associated with apoptosis through lipid peroxidation and protein kinase C activation in C6 glioma cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10222418&form=6&db=m Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391150&form=6&db=m Picroliv -- a natural product protects cells and regulates the gene expression during hypoxia/reoxygenation. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403815&form=6&db=m Sphingosine and phorbol ester modulate protein kinase C activity and modify ATP-evoked calcium mobilization in glioma C6 cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408397&form=6&db=m Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10453985&form=6&db=m Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10555965&form=6&db=m Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571407&form=6&db=m The role of protein kinase Calpha in U-87 glioma invasion. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10646507&form=6&db=m Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10761027&form=6&db=m Antisense Oligodeoxynucleotide Technology: Potential Use for the Treatment of Malignant Brain Tumors. therapeutic application,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10777597&form=6&db=m Structural determinants for post-transcriptional stabilization of lactate dehydrogenase A mRNA by the protein kinase C signal pathway. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10848585&form=6&db=m Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression. causal interaction,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059834&form=6&db=m Differential expression of protein kinase C subtypes during ginsenoside Rh2-lnduced apoptosis in SK-N-BE(2) and C6Bu-1 cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062054&form=6&db=m Changes in protein kinase C epsilon phosphorylation status and intracellular localization as 3T3 and 3T6 fibroblasts grow to confluency and quiescence: a role for phosphorylation at ser-729? unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170840&form=6&db=m Protein kinase Calpha isoform regulates the activation of the MAP kinase ERK1/2 in human glioma cells: involvement in cell survival and gene expression. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11174068&form=6&db=m Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11190577&form=6&db=m Modulation of protein kinase C in antitumor treatment. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221960&form=6&db=m Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates. causal interaction,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11284917&form=6&db=m Sensitivity of human glioma U-373MG cells to radiation and the protein kinase C inhibitor, calphostin C. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292171&form=6&db=m Ultrastructural study of protein kinase C-betaII localization during the cell cycle of human glioma cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11299321&form=6&db=m The role of protein kinase C in the regulation of serotonin-2A receptor expression. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331411&form=6&db=m Protein kinase C-mediated down-regulation of beta(2)-adrenergic receptor and gene expression in rat C6 glioma cells. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389098&form=6&db=m Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11414705&form=6&db=m A protective role of PKCepsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483662&form=6&db=m Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11525238&form=6&db=m Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704869&form=6&db=m Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11856176&form=6&db=m Human glioma PKC-iota and PKC-betaII phosphorylate cyclin-dependent kinase activating kinase during the cell cycle. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11927579&form=6&db=m Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. causal interaction,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934885&form=6&db=m The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11949827&form=6&db=m Tamoxifen increases photodynamic therapeutic response of U87 and U25ln human glioma cells. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130632&form=6&db=m Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237337&form=6&db=m Regulation of the neuronal glutamate transporter excitatory amino acid carrier-1 (EAAC1) by different protein kinase C subtypes. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12324450&form=6&db=m Protein kinase C activation decreases cell surface expression of the GLT-1 subtype of glutamate transporter. Requirement of a carboxyl-terminal domain and partial dependence on serine 486. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12407440&form=6&db=m Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12712458&form=6&db=m Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679066&form=6&db=m Protein kinase C mediates induced secretion of vascular endothelial growth factor by human glioma cells. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15062566&form=6&db=m Selective activation of protein kinase C isoforms by angiotensin II in neuroblastoma X glioma cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15081395&form=6&db=m Expression and regulation of phospholipase D isoforms in sphingosine and phorbol ester-stimulated glioma C6 cells. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15135084&form=6&db=m Penta-acetyl geniposide-induced C6 glioma cell apoptosis was associated with the activation of protein kinase C-delta. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15449107&form=6&db=m Specific gene suppression using antisense strategy for growth suppression of glioma. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531293&form=6&db=m Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. ongoing research,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683746&form=6&db=m Chloroquine induces the expression of inducible nitric oxide synthase in C6 glioma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701280&form=6&db=m Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842253&form=6&db=m Effects of the PKC inhibitor PD 406976 on cell cycle progression, proliferation, PKC isozymes and apoptosis in glioma and SVG-transformed glial cells. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103081&form=6&db=m Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376586&form=6&db=m Induction of BAALC and down regulation of RAMP3 in astrocytes treated with differentiation inducers. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16396605&form=6&db=m Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424044&form=6&db=m Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin. causal interaction,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16623718&form=6&db=m Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899228&form=6&db=m Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16959960&form=6&db=m Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079735&form=6&db=m Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17592532&form=6&db=m Changes of Src-suppressed C kinase substrate expression in cytokine induced reactive C6 glioma cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17803520&form=6&db=m Involvement of protein kinase C in melatonin's oncostatic effect in C6 glioma cells. ongoing research,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855624&form=6&db=m EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18294404&form=6&db=m Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. causal interaction,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448327&form=6&db=m Enzastaurin renders MCF-7 breast cancer cells sensitive to radiation through reversal of radiation-induced activation of protein kinase C. therapeutic application,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462865&form=6&db=m The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508315&form=6&db=m PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18778746&form=6&db=m The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18973186&form=6&db=m Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression. ongoing research,unassigned 2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19126647&form=6&db=m Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19133225&form=6&db=m Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19169273&form=6&db=m Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19176518&form=6&db=m EGFR signals to mTOR through PKC and independently of Akt in glioma. causal interaction,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19761816&form=6&db=m Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19773446&form=6&db=m Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. causal interaction,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19965895&form=6&db=m Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20654386&form=6&db=m Protein kinase C inhibitors arrest the C6 glioma cell cycle at a mid-G1 phase restriction point: Implications for the antiproliferative action of valproate. therapeutic application,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20871643&form=6&db=m Activation of PKC-alpha is required for migration of C6 glioma cells. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20967886&form=6&db=m PKC-dependent inhibition of CA(2+)-dependent exocytosis from astrocytes. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21777672&form=6&db=m RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23149578&form=6&db=m Nicotine- and tar-free cigarette smoke extract induces cell injury via intracellular Ca2+-dependent subtype-specific protein kinase C activation. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23358475&form=6&db=m PKC signaling in glioblastoma. causal interaction,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24179523&form=6&db=m Inhibition of ?-opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways. unassigned - 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24463355&form=6&db=m Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26459812&form=6&db=m Current status and future directions of anti-angiogenic therapy for gliomas. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28237688&form=6&db=m The flashlights on a distinct role of protein kinase C ?: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells. ongoing research,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28459217&form=6&db=m Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29410069&form=6&db=m In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. causal interaction,unassigned 3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29476136&form=6&db=m A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29793862&form=6&db=m Protein kinase C-dependent cell damage by unsaturated carbonyl compounds in vascular cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29946338&form=6&db=m Measuring the lactate-to-creatine ratio via 1H NMR spectroscopy can be used to noninvasively evaluate apoptosis in glioma cells after X-ray irradiation. ongoing research,unassigned 4,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816530&form=6&db=m In silico analysis identified miRNA?based therapeutic agents against glioblastoma multiforme. therapeutic application,unassigned 1,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31771098&form=6&db=m Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-phase Arrest on Glioma Cell Lines. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.13 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442674&form=6&db=m Searching for combination therapy by clustering methods: Stimulation of PKC in Golgi apparatus combined with hypericin induced PDT. ongoing research,unassigned 1,0 2.7.11.13 Gliosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402232&form=6&db=m Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9208282&form=6&db=m Protein kinase C beta II isoform is up-regulated in human proliferative glomerulonephritis. unassigned - 2.7.11.13 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575103&form=6&db=m Protein kinase C ß inhibition ameliorates experimental mesangial proliferative glomerulonephritis. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24998921&form=6&db=m Expression of Ser729 phosphorylated PKCepsilon in experimental crescentic glomerulonephritis: an immunohistochemical study. ongoing research,unassigned 3,0 2.7.11.13 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33240910&form=6&db=m The Network of Inflammatory Mechanisms in Lupus Nephritis. causal interaction,unassigned 4,0 2.7.11.13 Glomerulonephritis, Membranoproliferative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758661&form=6&db=m Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16775601&form=6&db=m Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Glucagonoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7517367&form=6&db=m Expression, intracellular localization, and gene transcription regulation of the secretory protein 7B2 in endocrine pancreatic cell lines and human insulinomas. ongoing research,unassigned 1,0 2.7.11.13 Glucagonoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7894192&form=6&db=m An immunohistochemical study of glucagonoma conducted on the metastatic lymph nodes from a patient with recurrent metastatic glucagonoma: report of a case. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11916925&form=6&db=m Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882907&form=6&db=m Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise. unassigned - 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908560&form=6&db=m Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809797&form=6&db=m Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620996&form=6&db=m PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469261&form=6&db=m Protein kinase c? modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23630453&form=6&db=m PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23700535&form=6&db=m Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance. causal interaction,unassigned 4,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237474&form=6&db=m Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073831&form=6&db=m Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32305097&form=6&db=m Deconstructing the Role of PKC Epsilon in Glucose Homeostasis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Goiter http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1807790&form=6&db=m Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Gram-Negative Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18458086&form=6&db=m The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors. unassigned - 2.7.11.13 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8002645&form=6&db=m Inhibition of a model of in vitro granuloma formation by tetracyclines and ciprofloxacin. Involvement of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30504889&form=6&db=m An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas. unassigned - 2.7.11.13 Granulomatous Disease, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3339016&form=6&db=m Purified protein kinase C phosphorylates a 47-kDa protein in control neutrophil cytoplasts but not in neutrophil cytoplasts from patients with the autosomal form of chronic granulomatous disease. unassigned - 2.7.11.13 Granulomatous Disease, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144669&form=6&db=m Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester. unassigned - 2.7.11.13 Granulomatous Disease, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8338957&form=6&db=m Protein kinases potentially capable of catalyzing the phosphorylation of p47-phox in normal neutrophils and neutrophils of patients with chronic granulomatous disease. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Granulomatous Disease, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9864180&form=6&db=m Activation of the human immunodeficiency virus-1 long terminal repeat by respiratory burst oxidants of neutrophils. unassigned - 2.7.11.13 Growth Hormone-Secreting Pituitary Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2060147&form=6&db=m Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture. causal interaction,unassigned 3,0 2.7.11.13 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567682&form=6&db=m Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.7.11.13 Hearing Loss, Noise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12966801&form=6&db=m [Protective effect of indirect activator of calcium pump on noise-induced hearing loss] ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Hearing Loss, Sensorineural http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21756056&form=6&db=m Contribution of 1425G/A Polymorphism in Protein Kinase C-Eta (PRKCH) Gene and Brain White Matter Lesions to the Risk of Sudden Sensorineural Hearing Loss in a Japanese Nested Case-Control Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.7.11.13 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716854&form=6&db=m Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15927822&form=6&db=m Protein kinase C and synaptic dysfunction after cardiac arrest. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19493168&form=6&db=m Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel. unassigned - 2.7.11.13 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24447953&form=6&db=m Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29843155&form=6&db=m Hydrogen Sulfide Decreases Blood-Brain Barrier Damage via Regulating Protein Kinase C and Tight Junction After Cardiac Arrest in Rats. unassigned - 2.7.11.13 Heart Defects, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10638675&form=6&db=m Isoforms of troponin in normal and diseased myocardium. therapeutic application,unassigned 1,0 2.7.11.13 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553773&form=6&db=m Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. causal interaction,unassigned 3,0 2.7.11.13 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596021&form=6&db=m Protein kinase C in cardiac disease and as a potential therapeutic target. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919087&form=6&db=m PKC isozymes in chronic cardiac disease: possible therapeutic targets? causal interaction,unassigned 3,0 2.7.11.13 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19556521&form=6&db=m Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.7.11.13 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24510065&form=6&db=m Heart failure-specific changes in protein kinase signalling. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24585778&form=6&db=m LENGTH-DEPENDENT ACTIVATION IS MODULATED BY CARDIAC TROPONIN I BISPHOSPHORYLATION AT SER23 AND SER24 BUT NOT BY THR143 PHOSPHORYLATION. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25420887&form=6&db=m The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta. causal interaction,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585333&form=6&db=m Peripheral vascular smooth muscle responsiveness to tumour-promoting phorbol esters in pacing-induced heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8263960&form=6&db=m Regulation of the endothelin-1 transmembrane signaling pathway: the potential role of agonist-induced desensitization in the coronary artery of the rapid ventricular pacing-overdrive dog model of heart failure. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9649559&form=6&db=m In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9887017&form=6&db=m Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9918525&form=6&db=m Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. causal interaction,unassigned 3,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375719&form=6&db=m Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy. causal interaction,unassigned 3,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728414&form=6&db=m Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003851&form=6&db=m alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI. therapeutic application,unassigned 2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196463&form=6&db=m Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12392998&form=6&db=m Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12619877&form=6&db=m Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742831&form=6&db=m Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887134&form=6&db=m Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575310&form=6&db=m Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741699&form=6&db=m Beta- and alpha-adrenergic cross-signaling for L-type Ca current is impaired in transgenic mice with constitutive activation of epsilonPKC. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14966518&form=6&db=m PKC-alpha regulates cardiac contractility and propensity toward heart failure. therapeutic application,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15614336&form=6&db=m Searching for the missing link: a role for the actin capping protein in heart failure. therapeutic application,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840586&form=6&db=m Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951344&form=6&db=m Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376870&form=6&db=m Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium. unassigned - 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16445938&form=6&db=m Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. unassigned - 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16519895&form=6&db=m Protein kinase C, troponin I and heart failure: overexpressed, hyperphosphorylated and underappreciated? unassigned - 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16880328&form=6&db=m Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900949&form=6&db=m Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload. ongoing research,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16932076&form=6&db=m Effect of endothelins on the cardiovascular system. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039281&form=6&db=m Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17251681&form=6&db=m Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261657&form=6&db=m Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. therapeutic application,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17303699&form=6&db=m The thrill can kill: murder by methylation. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17556659&form=6&db=m Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594058&form=6&db=m Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17628588&form=6&db=m Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue. therapeutic application,unassigned 3,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17655859&form=6&db=m Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. causal interaction,unassigned 2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921332&form=6&db=m Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18219172&form=6&db=m Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413490&form=6&db=m Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure. therapeutic application,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18804478&form=6&db=m Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19122165&form=6&db=m Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. causal interaction,unassigned 3,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168855&form=6&db=m Protein kinase C in heart failure: a therapeutic target? causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19426736&form=6&db=m Differential Effects of Phosphorylation of Regions of Troponin I in Modifying Cooperative Activation of Cardiac Thin Filaments. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19556521&form=6&db=m Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709863&form=6&db=m Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G{alpha}q protein-induced cardiomyopathy. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20723002&form=6&db=m CPU228, a derivative of dofetilide, relieves cardiac dysfunction by normalizing FKBP12.6, NADPH oxidase and protein kinase C epsilon in the myocardium. causal interaction,unassigned 2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20874722&form=6&db=m PKC?II inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses: PKC?II in cardiac remodeling. unassigned - 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937286&form=6&db=m Protein kinase C? as a heart failure therapeutic target. causal interaction,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131481&form=6&db=m Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes. causal interaction,unassigned 2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21151743&form=6&db=m Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21548979&form=6&db=m Differential regulation of diacylglycerol kinase isoform in human failing hearts. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22158646&form=6&db=m PKC-ing is believing: targeting protein kinase C in heart failure. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23456446&form=6&db=m Role of microangiopathy in diabetic cardiomyopathy. causal interaction,unassigned 4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23756828&form=6&db=m Agonist activated PKC?II translocation and modulation of cardiac myocyte contractile function. causal interaction,unassigned 2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24510065&form=6&db=m Heart failure-specific changes in protein kinase signalling. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814372&form=6&db=m Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes. causal interaction,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24831479&form=6&db=m [Protein interacting with kinase C? mediates the down-regulation of myocardial norepinephrine transporter expression in mice with adriamycin-induced congestive heart failure]. therapeutic application,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25489662&form=6&db=m Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970394&form=6&db=m Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713345&form=6&db=m Protein Kinases as Drug Development Targets for Heart Disease Therapy. causal interaction,unassigned 4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28120175&form=6&db=m Regulatory Variants Modulate Protein Kinase C ? (PRKCA) Gene Expression in Human Heart. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587770&form=6&db=m Functional communication between PKC-targeted cardiac troponin I phosphorylation sites. therapeutic application,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29307535&form=6&db=m Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca ongoing research,unassigned 1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383124&form=6&db=m Genetic association between 1425G/A SNP in PRKCH and hypertrophic cardiomyopathy in a Chinese population. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366607&form=6&db=m Cardiac contractile dysfunction and protein kinase C-mediated myofilament phosphorylation in disease and aging. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32730770&form=6&db=m A review on Pimelea poisoning of livestock. unassigned - 2.7.11.13 Heart Septal Defects, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594058&form=6&db=m Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Hemangioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844823&form=6&db=m The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424642&form=6&db=m The role of protein kinase C-alpha in hematologic malignancies. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17922632&form=6&db=m The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28758099&form=6&db=m Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Hematoma, Subdural, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391584&form=6&db=m Early changes in second messenger but not receptor binding sites after acute subdural hematoma: an in vitro autoradiographic study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8709245&form=6&db=m Casein kinase II and protein kinase C modulate hepatitis delta virus RNA replication but not empty viral particle assembly. unassigned - 2.7.11.13 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9740772&form=6&db=m Assembly of hepatitis delta virus particles: package of multimeric hepatitis delta virus genomic RNA and role of phosphorylation. unassigned - 2.7.11.13 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526032&form=6&db=m Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. unassigned - 2.7.11.13 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21793318&form=6&db=m Protein kinase C alpha location and the expression of phospho-MEK and MDR1 in hepatitis virus-related hepatocellular carcinoma biopsies. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309924&form=6&db=m Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7966589&form=6&db=m Effect of core protein phosphorylation by protein kinase C on encapsidation of RNA within core particles of hepatitis B virus. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8116251&form=6&db=m Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathways. ongoing research,unassigned 2,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8210715&form=6&db=m The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C. causal interaction,unassigned 2,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8831721&form=6&db=m Identification of a protein kinase C (PKC) activator, daphnoretin, that suppresses hepatitis B virus gene expression in human hepatoma cells. ongoing research,unassigned 3,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11377708&form=6&db=m Phosphorylation of purified recombinant hepatitis B virus-X protein by mitogen-activated protein kinase and protein kinase C in vitro. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12804776&form=6&db=m PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20109160&form=6&db=m Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20127469&form=6&db=m Hepatitis B virus core interacts with the host cell nucleolar protein, nucleophosmin 1. causal interaction,diagnostic usage,unassigned 1,2,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21909416&form=6&db=m The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22832122&form=6&db=m Interferon-? suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10521461&form=6&db=m Protein kinase C recognizes the protein kinase A-binding motif of nonstructural protein 3 of hepatitis C virus. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722046&form=6&db=m A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC. unassigned - 2.7.11.13 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202202&form=6&db=m Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542633&form=6&db=m Conventional protein kinase C inhibition prevents alpha interferon-mediated hepatitis C virus replicon clearance by impairing STAT activation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16472601&form=6&db=m The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration. therapeutic application,unassigned 1,0 2.7.11.13 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18951948&form=6&db=m Regulation of the biochemical function of motif VI of HCV NTPase/helicase by the conserved Phe-loop. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23893289&form=6&db=m The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Hepatitis E http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28077314&form=6&db=m Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115615&form=6&db=m Hypoglycemia-induced VEGF expression is mediated by intracellular Ca2+ and protein kinase C signaling pathway in HepG2 human hepatoblastoma cells. ongoing research,unassigned 1,0 2.7.11.13 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11481619&form=6&db=m Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells. ongoing research,unassigned 4,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835720&form=6&db=m Phospholipid-sensitive, Ca2+-dependent protein kinase activity in rat embryo fibroblasts transformed by herpes simplex virus type 2. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7815513&form=6&db=m Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8742363&form=6&db=m Role of tyrosine kinases, protein kinase C, and protein kinase A in the regulation of interferon-alpha production induced by herpes simplex virus type 1. unassigned - 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8880383&form=6&db=m Growth inhibition of herpes simplex virus-type 1 in calphostin C-treated astrocytes. ongoing research,unassigned 4,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592092&form=6&db=m Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons. ongoing research,unassigned 3,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11589990&form=6&db=m Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons. ongoing research,unassigned 3,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12691833&form=6&db=m Gene transfer of constitutively active protein kinase C into striatal neurons accelerates onset of levodopa-induced motor response alterations in parkinsonian rats. ongoing research,unassigned 4,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352573&form=6&db=m Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18973552&form=6&db=m Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons. therapeutic application,unassigned 2,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280321&form=6&db=m Phosphorylation of atrial natriuretic factor R1 receptor by serine/threonine protein kinases: evidences for receptor regulation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657659&form=6&db=m The protein kinase C content is increased in the nuclear fraction of rat adrenal zona glomerulosa following long-term ACTH administration. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1954174&form=6&db=m The biosynthesis of aldosterone. unassigned - 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2397025&form=6&db=m Trypsin stimulation of aldosterone and 18-hydroxycorticosterone production by rat adrenal zona glomerulosa tissue is mediated by activation of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7632615&form=6&db=m A role for protein tyrosine kinase in the steroidogenic pathway of angiotensin II in bovine zona glomerulosa cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7632850&form=6&db=m Effect of protein kinase C stimulators on zona pellucida binding and the acrosome reaction of macaque sperm. ongoing research,unassigned 1,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980607&form=6&db=m Internalization of the type I angiotensin II receptor (AT1) is required for protein kinase C activation but not for inositol trisphosphate release in the angiotensin II stimulated rat adrenal zona glomerulosa cell. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8318579&form=6&db=m Regulation of the polyspermy block in the mouse egg: maturation-dependent differences in cortical granule exocytosis and zona pellucida modifications induced by inositol 1,4,5-trisphosphate and an activator of protein kinase C. unassigned - 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464848&form=6&db=m Protein kinase C plays an important role in the human zona pellucida-induced acrosome reaction. ongoing research,unassigned 1,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9571176&form=6&db=m Protein kinase C activation stimulates calcium transport in adrenal zona glomerulosa cells. unassigned - 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115506&form=6&db=m Control of CYP11B2 gene expression through differential regulation of its promoter by atypical and conventional protein kinase C isoforms. ongoing research,unassigned 2,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196412&form=6&db=m Regulation of CYP11B2 gene expression by protein kinase C. unassigned - 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065412&form=6&db=m PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. therapeutic application,unassigned 1,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20980388&form=6&db=m The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1. unassigned - 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24190885&form=6&db=m Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils. unassigned - 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24338688&form=6&db=m Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ?-mediated zona occludens-1 phosphorylation at threonine 770/772. causal interaction,unassigned 2,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26045255&form=6&db=m Effects of sevoflurane on tight junction protein expression and PKC-? translocation after pulmonary ischemia-reperfusion injury. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961393&form=6&db=m Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. unassigned - 2.7.11.13 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824571&form=6&db=m Correction: Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ?-mediated zona occludens-1 phosphorylation at threonine 770/772. unassigned - 2.7.11.13 Hirschsprung Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17728459&form=6&db=m Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity. causal interaction,unassigned 3,0 2.7.11.13 Histiocytoma, Benign Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24721208&form=6&db=m Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma. unassigned - 2.7.11.13 Histiocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12764746&form=6&db=m Interferon-alpha therapy, protein kinase C-alpha and Langerhans cell histiocytosis. therapeutic application,unassigned 4,0 2.7.11.13 Histiocytosis, Langerhans-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12764746&form=6&db=m Interferon-alpha therapy, protein kinase C-alpha and Langerhans cell histiocytosis. therapeutic application,unassigned 4,0 2.7.11.13 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2143169&form=6&db=m Human immunodeficiency virus infection of monocytes: relationship to Fc-gamma receptors and antibody-dependent viral enhancement. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8523529&form=6&db=m Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9477117&form=6&db=m Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816239&form=6&db=m Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574879&form=6&db=m Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25287643&form=6&db=m Targeting NF-?B signaling with protein kinase C agonists as an emerging strategy for combating HIV latency. ongoing research,unassigned 2,0 2.7.11.13 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12058280&form=6&db=m Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis. therapeutic application,unassigned 1,0 2.7.11.13 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786031&form=6&db=m PKCeta Expression Contributes to the Resistance of Hodgkin's Lymphoma Cell Lines to Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.7.11.13 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1387337&form=6&db=m The loss of beta II-protein kinase C in the striatum from patients with Huntington's disease. ongoing research,unassigned 2,0 2.7.11.13 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8093576&form=6&db=m Second messenger systems in brains of patients with Parkinson's or Huntington's disease. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11291528&form=6&db=m Protein kinase C beta II mRNA levels decrease in the striatum and cortex of transgenic Huntington's disease mice. ongoing research,unassigned 3,0 2.7.11.13 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960759&form=6&db=m Impaired degradation of PKCalpha by proteasome in a cellular model of Huntington's disease. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14511117&form=6&db=m Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease. ongoing research,unassigned 4,0 2.7.11.13 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32762399&form=6&db=m A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. causal interaction,unassigned 1,0 2.7.11.13 Hyperaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9040443&form=6&db=m Increased Na(+)-H+ exchange in red blood cells of patients with primary aldosteronism. ongoing research,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1722888&form=6&db=m Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7478678&form=6&db=m Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7526941&form=6&db=m Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model. causal interaction,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7751909&form=6&db=m Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908958&form=6&db=m Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7983528&form=6&db=m Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. causal interaction,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384119&form=6&db=m The effects of phorbol ester on slowly conducting afferents of the cat's knee joint. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592645&form=6&db=m Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy. causal interaction,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9053788&form=6&db=m Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-D-aspartate receptors and protein kinase C and production of nitric oxide. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211478&form=6&db=m The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin. therapeutic application,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9952097&form=6&db=m Spinal mechanisms of acute and persistent pain. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10081603&form=6&db=m Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10393881&form=6&db=m Supraspinal contributions to hyperalgesia. causal interaction,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10395015&form=6&db=m Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice. causal interaction,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10624801&form=6&db=m Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10677042&form=6&db=m A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. ongoing research,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708714&form=6&db=m Effect of diabetes on bradykinin-induced thermal hyperalgesia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10793237&form=6&db=m Involvement of spinal protein kinase C in induction and maintenance of both persistent spontaneous flinching reflex and contralateral heat hyperalgesia induced by subcutaneous bee venom in the conscious rat. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10889342&form=6&db=m Loose ligation of the rat sciatic nerve is accompanied by changes in the subcellular content of protein kinase C beta II and gamma in the spinal dorsal horn. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10969147&form=6&db=m Involvement of spinal protein kinase C in thermal hyperalgesia evoked by partial sciatic nerve ligation, but not by inflammation in the mouse. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10986346&form=6&db=m Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069970&form=6&db=m Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11438608&form=6&db=m PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11440817&form=6&db=m Hyperalgesia induced by peripheral inflammation is mediated by protein kinase C betaII isozyme in the rat spinal cord. ongoing research,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11454025&form=6&db=m Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11517280&form=6&db=m Nociceptor sensitization by extracellular signal-regulated kinases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11698038&form=6&db=m Reduced hyperalgesia induced by nerve injury, but not by inflammation in mice lacking protein kinase C gamma isoform. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704642&form=6&db=m Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11983324&form=6&db=m Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12091579&form=6&db=m Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560106&form=6&db=m D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12582831&form=6&db=m Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12694383&form=6&db=m State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752784&form=6&db=m Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809704&form=6&db=m Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12849754&form=6&db=m Transient attenuation of protein kinase Cepsilon can terminate a chronic hyperalgesic state in the rat. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882929&form=6&db=m Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925276&form=6&db=m Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12927197&form=6&db=m Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499430&form=6&db=m Hyperalgesic priming in the rat demonstrates marked sexual dimorphism. causal interaction,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14622740&form=6&db=m Sympathetic-independent bradykinin mechanical hyperalgesia induced by subdiaphragmatic vagotomy in the rat. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667440&form=6&db=m Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14768516&form=6&db=m Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179546&form=6&db=m Inhibition of the morphine-induced rewarding effect by direct activation of spinal protein kinase C in mice. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15195086&form=6&db=m Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. causal interaction,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15223308&form=6&db=m H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15223385&form=6&db=m Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15275778&form=6&db=m Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. ongoing research,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15836617&form=6&db=m Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in mice. therapeutic application,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15836982&form=6&db=m Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987941&form=6&db=m Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16026476&form=6&db=m Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16084468&form=6&db=m Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16271370&form=6&db=m Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin. therapeutic application,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564637&form=6&db=m Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16584564&form=6&db=m Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597741&form=6&db=m A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. causal interaction,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16687502&form=6&db=m Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16730785&form=6&db=m Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16741065&form=6&db=m Mechanical hyperalgesia induced by endothelin-1 in rats is mediated via phospholipase C, protein kinase C, and MAP kinases. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16793902&form=6&db=m Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16800864&form=6&db=m Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17157774&form=6&db=m TrkA and PKC-epsilon in thermal burn-induced mechanical hyperalgesia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204374&form=6&db=m Severity of alcohol-induced painful peripheral neuropathy in female rats: role of estrogen and protein kinase (A and Cepsilon). causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17343847&form=6&db=m Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350763&form=6&db=m PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17473449&form=6&db=m Contribution of Ca(2+) -dependent protein kinase C in the spinal cord to the development of mechanical allodynia in diabetic mice. therapeutic application,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707592&form=6&db=m Enhanced inflammatory hyperalgesia after recovery from burn injury. therapeutic application,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893922&form=6&db=m Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats. therapeutic application,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17917111&form=6&db=m Pain Facilitation and Activity-Dependent Plasticity in Pain Modulatory Circuitry: Role of BDNF-TrkB Signaling and NMDA Receptors. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17978048&form=6&db=m Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17987109&form=6&db=m Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996026&form=6&db=m Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18077689&form=6&db=m Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18242849&form=6&db=m Implication of spinal protein kinase Cgamma isoform in activation of the mouse brain by intrathecal injection of the protein kinase C activator phorbol 12,13-dibutyrate using functional magnetic resonance imaging analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262361&form=6&db=m Implication of endogenous beta-endorphin in the inhibition of the morphine-induced rewarding effect by the direct activation of spinal protein kinase C in mice. ongoing research,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18387748&form=6&db=m Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18495351&form=6&db=m Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia. therapeutic application,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18685019&form=6&db=m Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19059398&form=6&db=m L1 cell adhesion molecule is essential for the maintenance of hyperalgesia after spinal cord injury. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19231080&form=6&db=m Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19275929&form=6&db=m Activation of G(i) induces mechanical hyperalgesia poststress or inflammation. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19575452&form=6&db=m Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630736&form=6&db=m Ethanol withdrawal and hyperalgesia. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794317&form=6&db=m Superoxide signaling in pain is independent of nitric oxide signaling. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043876&form=6&db=m Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20357116&form=6&db=m Shared mechanisms for opioid tolerance and a transition to chronic pain. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20362561&form=6&db=m Involvement of the spinal NMDA receptor/PKCgamma signaling pathway in the development of bone cancer pain. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20456866&form=6&db=m Multiple PKCepsilon-dependent mechanisms mediating mechanical hyperalgesia. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20457222&form=6&db=m Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709454&form=6&db=m Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice. therapeutic application,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20800074&form=6&db=m Prokineticin 2 suppresses GABA-activated current in rat primary sensory neurons. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21162189&form=6&db=m [Protein kinase C agonist phorbol 12-Myrstate-Acetate induces nociception and enhances nitric oxide production in the spinal cord of rats]. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21714841&form=6&db=m Progesterone Prevents Nerve Injury-Induced Allodynia and Spinal NMDA Receptor Upregulation in Rats. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21804201&form=6&db=m Prostaglandin e(2) and pain-an update. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22050217&form=6&db=m Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats: protein kinase C pathway involved. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22220695&form=6&db=m Inflammatory muscle pain is dependent on the activation of kinin B(1) and B(2) receptors and intracellular kinase pathways. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796071&form=6&db=m Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23379641&form=6&db=m Role of a novel nociceptor autocrine mechanism in chronic pain. therapeutic application,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23565709&form=6&db=m A single-center, randomized, double-blind, active, and placebo-controlled study of KAI-1678, a novel PKC-epsilon inhibitor, in the treatment of acute postoperative orthopedic pain. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23818225&form=6&db=m Protein kinase C gamma interneurons in the rat medullary dorsal horn: Distribution and synaptic inputs of these neurons, and subcellular localization of the enzyme. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23837410&form=6&db=m PKCgamma receptor mediates visceral nociception and hyperalgesia following exposure to PTSD-like stress in the spinal cord of rats. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24406203&form=6&db=m Differential regulation of peripheral IL-1?-induced mechanical allodynia and thermal hyperalgesia in rats. therapeutic application,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24407022&form=6&db=m Second messengers mediating the expression of neuroplasticity in a model of chronic pain in the rat. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25451626&form=6&db=m Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat. ongoing research,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25635962&form=6&db=m PKC?-positive neurons gate light tactile inputs to pain pathway through pERK1/2 neuronal network in trigeminal neuropathic pain model. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25745356&form=6&db=m Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors. ongoing research,unassigned 4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26434709&form=6&db=m The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats. therapeutic application,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26745451&form=6&db=m Protein Kinase C ? Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26750151&form=6&db=m Activation of medullary dorsal horn ? isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26996509&form=6&db=m Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation. therapeutic application,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27296114&form=6&db=m Activation of ?1 adrenoceptors in ventrolateral orbital cortex attenuates allodynia induced by spared nerve injury in rats. therapeutic application,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27537764&form=6&db=m PICK1 Regulates the Expression and Trafficking of AMPA Receptors in Remifentanil-Induced Hyperalgesia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27721335&form=6&db=m Real-Time Translocation and Function of PKC?II Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor. causal interaction,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27744376&form=6&db=m AMPK activation by peri-sciatic nerve administration of ozone attenuates CCI-induced neuropathic pain in rats. ongoing research,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28988976&form=6&db=m Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats. ongoing research,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29288797&form=6&db=m Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor. causal interaction,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29672451&form=6&db=m Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30147356&form=6&db=m The increased release of amino acid neurotransmitters of the primary somatosensory cortical area in rats contributes to remifentanil-induced hyperalgesia and its inhibition by lidocaine. diagnostic usage,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30282403&form=6&db=m Contribution of Spinal PKC? Expression to Short- and Long-lasting Pain Behaviors in Formalin-induced Inflamed Mice. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355630&form=6&db=m 5-HT2A Receptor-Induced Morphological Reorganization of PKC?-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30360692&form=6&db=m Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30553789&form=6&db=m Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats. ongoing research,unassigned 1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30900515&form=6&db=m Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31209174&form=6&db=m Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32101975&form=6&db=m Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice. causal interaction,unassigned 2,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32108249&form=6&db=m PKC? interneurons, a gateway to pathological pain in the dorsal horn. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33181066&form=6&db=m Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury. unassigned - 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33673008&form=6&db=m Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling. causal interaction,unassigned 3,0 2.7.11.13 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34433770&form=6&db=m Postnatal development of inner lamina II interneurons of the rat medullary dorsal horn. unassigned - 2.7.11.13 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15741835&form=6&db=m Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expression. unassigned - 2.7.11.13 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178122&form=6&db=m Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19395857&form=6&db=m Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. causal interaction,diagnostic usage,unassigned 1,2,0 2.7.11.13 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hypereosinophilic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846782&form=6&db=m Regulation of Fc gamma receptor subtype expression on a human eosinophilic leukemia cell line EoL-3: participation of cAMP and protein kinase C in the effects of interferon-gamma and phorbol ester. ongoing research,unassigned 4,0 2.7.11.13 Hypereosinophilic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664934&form=6&db=m The roles of MCP-1 and protein kinase Cdelta activation in human eosinophilic leukemia EoL-1 cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2708528&form=6&db=m Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7485561&form=6&db=m Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C. causal interaction,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7508912&form=6&db=m Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7635966&form=6&db=m Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7698515&form=6&db=m Hyperglycemia-induced changes in Na+/myo-inositol transport, Na(+)-K(+)-ATPase, and protein kinase C activity in proximal tubule cells. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7769136&form=6&db=m Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926314&form=6&db=m Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8489251&form=6&db=m Chronic effects of glucose on insulin signaling in A-10 vascular smooth muscle cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8707376&form=6&db=m Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9000691&form=6&db=m Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202063&form=6&db=m Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9217882&form=6&db=m Mechanisms underlying depressed Na+/Ca2+ exchanger activity in the diabetic heart. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256480&form=6&db=m Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458880&form=6&db=m Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9604860&form=6&db=m Protein kinase C activation and the development of diabetic complications. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9642153&form=6&db=m Effect of eicosapentaenoic acid on glucose-induced diacylglycerol synthesis in cultured bovine aortic endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9780781&form=6&db=m [Heart pathology of extracardiac origin. XI. Cardiac repercussions of diabetes mellitus] causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9864462&form=6&db=m Molecular mechanisms of diabetic complications. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872935&form=6&db=m Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9916130&form=6&db=m Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022775&form=6&db=m Increased expression of liver PKC alpha in hypoinsulinemic diabetic rats: a post-translational effect. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10331492&form=6&db=m Hyperglycemia in vitro attenuates insulin-stimulated chemokinesis in normal human neutrophils. Role of protein kinase C activation. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10342822&form=6&db=m Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571782&form=6&db=m Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10588370&form=6&db=m Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? causal interaction,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10688411&form=6&db=m Diabetic nephropathy--what have we learned in the last three decades? causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10841915&form=6&db=m Molecular mechanism of diabetic nephropathy. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11037624&form=6&db=m The role of protein kinase C in the development of the complications of diabetes. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11114100&form=6&db=m Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158959&form=6&db=m Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced betaII PKC activation. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304414&form=6&db=m Platelet protein kinase C isoform content in type 2 diabetes complicated with retinopathy and nephropathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331935&form=6&db=m Effects of hyperglycemia and protein kinase C on connexin43 expression in cultured rat retinal pigment epithelial cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11460589&form=6&db=m Pathogenesis of diabetic nephropathy. causal interaction,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11473058&form=6&db=m Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576522&form=6&db=m Effect of the postprandial state on nontraditional risk factors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576956&form=6&db=m Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11785657&form=6&db=m Protein kinase C inhibits insulin-induced Akt activation in vascular smooth muscle cells. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786509&form=6&db=m Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959624&form=6&db=m Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11978656&form=6&db=m Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187484&form=6&db=m Retinal metabolic abnormalities in diabetic mouse: comparison with diabetic rat. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217849&form=6&db=m Diabetic kidney disease: impact of puberty. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12372842&form=6&db=m Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12612945&form=6&db=m Progression of diabetic nephropathy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12623164&form=6&db=m Pathophysiological mechanisms of diabetic angiopathy. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12799318&form=6&db=m N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. therapeutic application,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882930&form=6&db=m Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960081&form=6&db=m Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14672811&form=6&db=m Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14698497&form=6&db=m Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway. ongoing research,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14966364&form=6&db=m Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14972096&form=6&db=m Mechanisms for early microvascular injury in obesity and type II diabetes. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252773&form=6&db=m Role of nitric oxide in diabetic nephropathy. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15262829&form=6&db=m Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15486306&form=6&db=m Inhibitory effect of high concentration of glucose on relaxations to activation of ATP-sensitive K+ channels in human omental artery. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563981&form=6&db=m Can diabetic neuropathy be prevented? unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15567345&form=6&db=m Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723618&form=6&db=m Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15724450&form=6&db=m PKCepsilon inhibits the hyperglycemia-induced apoptosis signal in adult rat ventricular myocytes. therapeutic application,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15793252&form=6&db=m Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15894568&form=6&db=m PKC-{varepsilon}-dependent survival signals in diabetic hearts. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15956119&form=6&db=m Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140162&form=6&db=m An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343639&form=6&db=m Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456234&form=6&db=m G protein-linked cell signaling and cardiovascular functions in diabetes/hyperglycemia. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16530129&form=6&db=m Endothelial dysfunction in type 2 diabetes mellitus. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16689387&form=6&db=m [Molecular mechanism of diabetic nephropathy] causal interaction,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17365661&form=6&db=m Retinal blood flow in diabetes. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720889&form=6&db=m New pharmacologic approaches to treating diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720893&form=6&db=m Screening for and managing diabetic retinopathy: current approaches. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17911348&form=6&db=m Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220582&form=6&db=m Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220622&form=6&db=m Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential component. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230953&form=6&db=m Hyperglycemia and the pathobiology of diabetic complications. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346469&form=6&db=m Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18488224&form=6&db=m NOX enzymes and diabetic complications. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18497343&form=6&db=m Demonstration of the essential role of protein kinase C isoforms in hyperglycemia-induced embryonic malformations. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18711746&form=6&db=m Regulation of protein kinases and coregulatory interplay of S-100beta and serotonin transporter on serotonin levels in diabetic rat brain. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18974277&form=6&db=m Role of protein kinase C in the expression of endothelin converting enzyme-1. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19279131&form=6&db=m Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19881493&form=6&db=m Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20184965&form=6&db=m Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446578&form=6&db=m [Disorder of vascular smooth muscle cell and platelet function in diabetes] causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21071702&form=6&db=m Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21179305&form=6&db=m Coronary microvascular dysfunction in diabetes mellitus: A review. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21280541&form=6&db=m Review on pathophysiology and treatment of diabetic kidney disease. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21321125&form=6&db=m PKC{alpha} Mediates {beta}-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21453786&form=6&db=m Cellular and molecular mechanisms of vascular injury in diabetes - Part I: Pathways of vascular disease in diabetes. causal interaction,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480517&form=6&db=m Hepatic steatosis by dietary-conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C ? in mice. ongoing research,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22148072&form=6&db=m Hyperglycemia enhances IGF-I-stimulated Src activation via increasing Nox4-derived reactive oxygen species in a PKC?-dependent manner in vascular smooth muscle cells. ongoing research,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22216119&form=6&db=m Protein kinase C delta (PKC?) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. therapeutic application,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22268114&form=6&db=m Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BKCa and Kir channels. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22346117&form=6&db=m Role of inflammation in the pathogenesis of diabetic retinopathy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22520069&form=6&db=m Oral targeting of protein kinase C receptor: promising route for diabetic retinopathy? causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22650227&form=6&db=m Metabolic memory for vascular disease in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22719800&form=6&db=m The impact of thiamine treatment in the diabetes mellitus. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22763581&form=6&db=m Glyco-oxidation and cardiovascular complications in type 2 diabetes: a clinical update. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22879735&form=6&db=m Protein kinase C activation affects, via the mRNA-binding Hu-antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model. ongoing research,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23103504&form=6&db=m Complex modulation of the expression of PKC isoforms in the rat brain during chronic type 1 diabetes mellitus. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23105858&form=6&db=m Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23207896&form=6&db=m Polyneuropathy in Impaired Glucose Tolerance: Is Postprandial Hyperglycemia the Main Culprit? A Mini-Review. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23393675&form=6&db=m Nephropathy in diabetes. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23403705&form=6&db=m Effect of short-term hyperglycemia on protein kinase C alpha activation in human erythrocytes. ongoing research,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23448484&form=6&db=m Hyperglycemia-induced Oxidative stress and its Role in Diabetes Mellitus related Cardiovascular Diseases. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23557702&form=6&db=m PKC? impaired vessel formation and angiogenic factor expression in diabetic ischemic limbs. diagnostic usage,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23775122&form=6&db=m Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24373831&form=6&db=m Diabetic peripheral neuropathy: current perspective and future directions. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24843457&form=6&db=m Mechanism of diabetic neuropathy: Where are we now and where to go? unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24997452&form=6&db=m Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450812&form=6&db=m Type 2 diabetes mellitus: Role of melatonin and oxidative stress. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450817&form=6&db=m Diabetic retinopathy--biomolecules and multiple pathophysiology. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701431&form=6&db=m NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early-stage diabetic kidney. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25990316&form=6&db=m The vulnerable vessel. Vascular disease in diabetes mellitus. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26501476&form=6&db=m The Protein Kinase C Inhibitor: Ruboxistaurin. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648059&form=6&db=m Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26798569&form=6&db=m Drug Targets for Oxidative Podocyte Injury in Diabetic Nephropathy. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26897277&form=6&db=m The Effect of Short-Term Hyperglycemia on the Innate Immune System. therapeutic application,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27059477&form=6&db=m Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27133148&form=6&db=m Glucotoxic Mechanisms and Related Therapeutic Approaches. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28058263&form=6&db=m Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function. causal interaction,unassigned 2,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539797&form=6&db=m Clinical biomarkers and molecular basis for optimized treatment of diabetic retinopathy: current status and future prospects. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29297254&form=6&db=m Amelioration of diabetic nephropathy by oral administration of d-?-tocopherol and its mechanisms. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29988567&form=6&db=m Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30098549&form=6&db=m Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity. therapeutic application,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30219206&form=6&db=m [Is reduction of hyperglycemia associated with a cardiovascular benefit?] unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30254714&form=6&db=m The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy. therapeutic application,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30384259&form=6&db=m New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402502&form=6&db=m Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30409037&form=6&db=m Type-2 diabetes mellitus and cardiovascular disease. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30551523&form=6&db=m A non-invasive, multi-target approach to treat diabetic retinopathy. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30581303&form=6&db=m Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30813879&form=6&db=m Review of Diabetic Polyneuropathy: Pathogenesis, Diagnosis and Management According to the Consensus of Egyptian Experts. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930073&form=6&db=m Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30934385&form=6&db=m Role of protein kinase C in diabetic complications. causal interaction,unassigned 3,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32454710&form=6&db=m Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32505477&form=6&db=m Molecular complexities underlying the vascular complications of diabetes mellitus - A comprehensive review. causal interaction,unassigned 4,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33068369&form=6&db=m Immune response to fungi in diabetic patients with invasive fungal rhinosinusitis. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33123598&form=6&db=m Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications. unassigned - 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33248932&form=6&db=m Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications. causal interaction,unassigned 1,0 2.7.11.13 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34439482&form=6&db=m Oxidative Stress Biomarkers in the Relationship between Type 2 Diabetes and Air Pollution. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1423925&form=6&db=m Polymyxin-B suppresses endotoxin-induced insulin hypersecretion in pancreatic islets. therapeutic application,unassigned 3,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1858953&form=6&db=m Antagonism of endotoxic glucose dyshomeostasis by protein kinase C inhibitors. unassigned - 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8914428&form=6&db=m [Hypertension in the patients with impaired glucose tolerance] unassigned - 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523399&form=6&db=m Potential role of glycerol leading to rat fructose hypertension. therapeutic application,unassigned 1,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10842665&form=6&db=m Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models. causal interaction,unassigned 3,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882599&form=6&db=m Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. causal interaction,unassigned 3,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217885&form=6&db=m Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12623995&form=6&db=m Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha. causal interaction,unassigned 4,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069075&form=6&db=m Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. therapeutic application,unassigned 1,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16611834&form=6&db=m Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16781675&form=6&db=m Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882599&form=6&db=m Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. causal interaction,unassigned 3,0 2.7.11.13 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044008&form=6&db=m Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study. therapeutic application,unassigned 1,0 2.7.11.13 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15143153&form=6&db=m Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16718817&form=6&db=m Hyperlipidemia intensifies cerulein-induced acute pancreatitis associated with activation of protein kinase C in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.7.11.13 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237474&form=6&db=m Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hyperparathyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1642085&form=6&db=m Regulation of parathyroid hormone release in normal and pathological parathyroid cells exposed to modulators of protein kinase C. causal interaction,unassigned 4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3241220&form=6&db=m Impaired phospholipase C activity is involved in the hyperreactivity of platelets in primary hypertension. causal interaction,unassigned 2,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7539147&form=6&db=m Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. ongoing research,unassigned 2,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022617&form=6&db=m Phosphorylation-mediated control of chromatin organization and transcriptional activity of the tissue-specific osteocalcin gene. therapeutic application,unassigned 1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762308&form=6&db=m Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury. causal interaction,unassigned 4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10844037&form=6&db=m Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. causal interaction,unassigned 2,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667440&form=6&db=m Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715401&form=6&db=m Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739559&form=6&db=m Differential roles of spinal protein kinases C and a in development of primary heat and mechanical hypersensitivity induced by subcutaneous bee venom chemical injury in the rat. ongoing research,unassigned 4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16227394&form=6&db=m A role for PKCzeta in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin. ongoing research,unassigned 2,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17306466&form=6&db=m Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696523&form=6&db=m Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21291534&form=6&db=m Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635764&form=6&db=m Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats. ongoing research,unassigned 1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23004934&form=6&db=m Neonatal protein kinase C zeta expression determines the neonatal T-Cell cytokine phenotype and predicts the development and severity of infant allergic disease. causal interaction,unassigned 4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23470774&form=6&db=m Surgical incision induces phosphorylation of AMPA receptor GluR1 subunits at Serine-831 sites and GluR1 trafficking in spinal cord dorsal horn via a protein kinase C?-dependent mechanism. causal interaction,unassigned 3,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25292211&form=6&db=m The tao of IGF-1: insulin-like growth factor receptor activation increases pain by enhancing T-type calcium channel activity. causal interaction,unassigned 1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25547463&form=6&db=m Loss of ICA69 Potentiates Long-Lasting Hyperalgesia After Subcutaneous Formalin Injection into the Mouse Hindpaw. therapeutic application,unassigned 1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25635962&form=6&db=m PKC?-positive neurons gate light tactile inputs to pain pathway through pERK1/2 neuronal network in trigeminal neuropathic pain model. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27296621&form=6&db=m Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27304220&form=6&db=m TSLP regulates eosinophil migration via phosphorylation of L-plastin in atopic dermatitis. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27335876&form=6&db=m PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior. therapeutic application,unassigned 2,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27346325&form=6&db=m Lamina specific postnatal development of PKC? interneurons within the rat medullary dorsal horn. causal interaction,unassigned 2,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28343377&form=6&db=m Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach. causal interaction,unassigned 3,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28621704&form=6&db=m Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity. ongoing research,unassigned 2,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29980697&form=6&db=m Spinal PKC? inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons. unassigned - 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30639112&form=6&db=m Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31101759&form=6&db=m Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity. therapeutic application,unassigned 1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31385361&form=6&db=m Protein kinase C-? upregulates sodium channel Nav1.9 in nociceptive dorsal root ganglion neurons in an inflammatory arthritis pain model of rat. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31407399&form=6&db=m Regulation of the firing activity by PKA-PKC-Src family kinases in cultured neurons of hypothalamic arcuate nucleus. causal interaction,unassigned 4,0 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31567367&form=6&db=m Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31705725&form=6&db=m Activation of the RAS/B-RAF-MEK-ERK pathway in satellite glial cells contributes to substance p-mediated orofacial pain. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Hypersensitivity, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10755475&form=6&db=m On the activity of trifluoperazine and palmitoylcarnitine in mice: delayed hypersensitivity models. therapeutic application,unassigned 1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280321&form=6&db=m Phosphorylation of atrial natriuretic factor R1 receptor by serine/threonine protein kinases: evidences for receptor regulation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336404&form=6&db=m The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1381046&form=6&db=m Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension. causal interaction,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1699554&form=6&db=m Calcium and contractile responses to phorbol esters and the calcium channel agonist, Bay K 8644, in arteries from hypertensive rats. causal interaction,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165266&form=6&db=m Volume-dependent regulation of cation transport and polyphosphoinositide metabolism in human and rat erythrocytes: features revealed in primary hypertension. causal interaction,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165267&form=6&db=m Protein kinase C activity in erythrocytes in primary hypertension: regulation of cell shape and cation transport. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175627&form=6&db=m The role of protein kinase C and calcium in the regulation of norepinephrine release from the vascular adrenergic neurons in hypertension. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2177334&form=6&db=m Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2313587&form=6&db=m Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension. ongoing research,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2369799&form=6&db=m Effects of a protein kinase C inhibitor (H-7) on norepinephrine release from vascular adrenergic neurons in spontaneously hypertensive rats. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2758236&form=6&db=m The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2804296&form=6&db=m [Protein kinase C activity in the brain tissue of spontaneously hypertensive rats] causal interaction,unassigned 3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837604&form=6&db=m [Univalent cation transport in human and rat erythrocytes: its regulation by protein kinase activators and compression] causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3060355&form=6&db=m Effects of lead on vascular reactivity. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3169942&form=6&db=m Effect of protein kinase C activation on cytoskeleton and cation transport in human erythrocytes. Reproduction of some membrane abnormalities revealed in essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3235834&form=6&db=m Activity of protein kinase C in erythrocytes in primary hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3241191&form=6&db=m Possible involvement of protein kinase C in the maintenance of hypertension in spontaneously hypertensive rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3241220&form=6&db=m Impaired phospholipase C activity is involved in the hyperreactivity of platelets in primary hypertension. causal interaction,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3241255&form=6&db=m Protein kinase C-dependent and calmodulin-dependent regulation of neurotransmitter release and vascular responsiveness in spontaneously hypertensive rats. ongoing research,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3437672&form=6&db=m [Membrane defect in primary arterial hypertension: a reflection of dysfunction of cellular oncogenes?] diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3599644&form=6&db=m [Erythrocyte membrane phosphorylation in rats with spontaneous hypertension as affected by protein kinase C activator] unassigned - 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3682579&form=6&db=m [Changes in erythrocyte volume in relation to characteristics of protein phosphorylation of the membrane cytoskeleton in hypertension: role of protein kinase C] ongoing research,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7685444&form=6&db=m Angiotensin II responses after protein kinase C activation in vascular smooth muscle cells of spontaneously hypertensive rats. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8113968&form=6&db=m Characterization of the alpha-1 adrenoceptors in the mesenteric vasculature from deoxycorticosterone-salt hypertensive rats: studies on vasoconstriction, radioligand binding and postreceptor events. unassigned - 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8574657&form=6&db=m Activation of protein kinase C does not participate in disruption of the blood-brain barrier to albumin during acute hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635246&form=6&db=m Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype. causal interaction,unassigned 3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8952590&form=6&db=m Chelerythrine inhibits Na(+)-H+ exchange in platelets from spontaneously hypertensive rats. unassigned - 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9072315&form=6&db=m Correlation analysis of blood pressure and platelet aggregation/vascular reactivity in SHRSP, WKY, F1 and backcross generations. unassigned - 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9162439&form=6&db=m Posttranslational effects of protein kinase C and insulin on red cell membrane phosphorylation and cation heteroexchange in hypertension. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9324113&form=6&db=m Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle? causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9627144&form=6&db=m Erythrocytic protein kinase C activity in primary hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9713323&form=6&db=m Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: effects of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat). causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604485&form=6&db=m Nitric oxide in cyclosporine A-induced hypertension: role of protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10619588&form=6&db=m The effects of angiotensin II, endothelin-1, and protein kinase C inhibitor on DNA synthesis and intracellular calcium mobilization in vascular smooth muscle cells from young normotensive and spontaneously hypertensive rats. ongoing research,unassigned 3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10682462&form=6&db=m [Study on the activity of platelets protein kinase C in patients with pregnancy induced hypertension] diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995592&form=6&db=m Role of protein kinase C in electrical-stimulation-induced neuronal nitric oxide release in mesenteric arteries from hypertensive rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11317187&form=6&db=m Lipid second messenger regulation: the role of diacylglycerol kinases and their relevance to hypertension. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11325868&form=6&db=m Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956212&form=6&db=m Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family. ongoing research,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187767&form=6&db=m [Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology] causal interaction,unassigned 3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388232&form=6&db=m Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523677&form=6&db=m Impaired response to insulin associated with protein kinase C in chronic fructose-induced hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12540629&form=6&db=m Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12544443&form=6&db=m Contribution of endogenous endothelin in the enhanced coronary constriction in DOCA-salt hypertensive rats. therapeutic application,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12585150&form=6&db=m [Effect of Erigeron breviscapus injection on ventricular and vascular remodeling in spontaneous hypertension rats] ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12612945&form=6&db=m Progression of diabetic nephropathy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12688398&form=6&db=m Role of protein kinase C in the regulation of acetylcholine release in the central nervous system of spontaneously hypertensive rats. ongoing research,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654761&form=6&db=m Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2. ongoing research,unassigned 3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14698497&form=6&db=m Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway. ongoing research,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14965035&form=6&db=m [Effect of inhibiting protein kinase C on calcium sensitivity of contractile apparatus of vascular smooth muscle during vasospasms of different origins] ongoing research,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15212975&form=6&db=m Endothelial dysfunction in aortic rings and mesenteric beds isolated from deoxycorticosterone acetate hypertensive rats: possible involvement of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15509134&form=6&db=m In vitro and ex vivo antioxidant activities of labetalol on rabbit neutrophil respiratory burst. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15792354&form=6&db=m Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15804434&form=6&db=m Role of protein kinase C beta in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains. unassigned - 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15980039&form=6&db=m Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension. unassigned - 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16077260&form=6&db=m Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney. ongoing research,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139252&form=6&db=m Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409305&form=6&db=m Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17666910&form=6&db=m NADPH oxidase inhibitors: new antihypertensive agents? therapeutic application,unassigned 3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174462&form=6&db=m AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. therapeutic application,unassigned 1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18641275&form=6&db=m Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension. causal interaction,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18832165&form=6&db=m The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19001187&form=6&db=m Angiotensin II-dependent hypertension increases Na transport-related oxygen consumption by the thick ascending limb. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19687351&form=6&db=m Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21141522&form=6&db=m [The transcript expression of renal PKC-alpha gene in pregnancy induced hypertension rats]. ongoing research,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21153149&form=6&db=m Tissue-dependent activation of protein kinase C in fructose-induced insulin resistance. therapeutic application,unassigned 1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23303165&form=6&db=m Regulator of g-protein signaling 5 controls blood pressure homeostasis and vessel wall remodeling. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23719203&form=6&db=m Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973649&form=6&db=m Correction of vascular hypercontractility in spontaneously hypertensive rats using shRNAs-induced delta protein kinase C gene silencing. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25313067&form=6&db=m Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25489059&form=6&db=m Prenatal Testosterone Exposure Induces Hypertension in Adult Females via Androgen Receptor-Dependent Protein Kinase C?-Mediated Mechanism. ongoing research,unassigned 2,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502583&form=6&db=m A Comprehensive Review of Erectile Dysfunction in Men with Diabetes. causal interaction,unassigned 4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916268&form=6&db=m Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia. unassigned - 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25931148&form=6&db=m PKC-mediated cerebral vasoconstriction: Role of myosin light chain phosphorylation versus actin cytoskeleton reorganization. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484605&form=6&db=m - causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31241170&form=6&db=m Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Hypertension, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113073&form=6&db=m ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy. causal interaction,unassigned 4,0 2.7.11.13 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7699222&form=6&db=m Altered prostacyclin synthesis by aortae from hepatic portal vein-constricted rats: evidence for effects on protein kinase C and calcium. causal interaction,unassigned 1,0 2.7.11.13 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735627&form=6&db=m Role of protein kinase C in mesenteric pressor responses of rats with portal hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10682462&form=6&db=m [Study on the activity of platelets protein kinase C in patients with pregnancy induced hypertension] diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21141522&form=6&db=m [The transcript expression of renal PKC-alpha gene in pregnancy induced hypertension rats]. ongoing research,unassigned 2,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11372384&form=6&db=m [The effect of ginkgo biloba on hypoxic pulmonary hypertension and the role of protein kinase C] ongoing research,unassigned 3,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11820949&form=6&db=m [The increased reactivity of isolated pulmonary artery rings from rats with hypoxia-induced pulmonary hypertension to activator of protein kinase C] ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866979&form=6&db=m [Effects of hypoxia on the expression of protein kinase C mRNA in pulmonary artery smooth muscle and endothelial cell] causal interaction,unassigned 4,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14733767&form=6&db=m The effect of protein kinase C on voltage-gated potassium channel in pulmonary artery smooth muscle cells from rats exposed to chronic hypoxia. causal interaction,unassigned 4,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15924930&form=6&db=m Activation of PKCalpha and pulmonary vascular remodelling in broilers. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16641035&form=6&db=m Changes in pulmonary arteriole protein kinase calpha expression associated with supplemental L-arginine in broilers during cool temperature exposure. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17468135&form=6&db=m Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584659&form=6&db=m [Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension] causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699685&form=6&db=m Role of Protein Kinase C{zeta} and Its Adaptor Protein p62 in Voltage-Gated Potassium Channel Modulation in Pulmonary Arteries. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19995357&form=6&db=m Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22293869&form=6&db=m Determination of PKC isoform-specific protein expression in pulmonary arteries of rats with chronic hypoxia-induced pulmonary hypertension. causal interaction,unassigned 1,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22837726&form=6&db=m Polydatin Attenuates Hypoxic Pulmonary Hypertension and Reverses Remodeling through Protein Kinase C Mechanisms. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765942&form=6&db=m Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Hypertension, Renal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3235834&form=6&db=m Activity of protein kinase C in erythrocytes in primary hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.7.11.13 Hypertension, Renal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3411869&form=6&db=m [Protein kinase A and C activity of erythrocytes in patients with essential hypertension] causal interaction,unassigned 4,0 2.7.11.13 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9893134&form=6&db=m Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: evidence for an involvement of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Hypertensive Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097471&form=6&db=m Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Hypertensive Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097480&form=6&db=m Hypertensive encephalopathy and the blood-brain barrier: is deltaPKC a gatekeeper? causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9713323&form=6&db=m Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: effects of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat). causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11043608&form=6&db=m Decreased protein kinase C-epsilon expression in hypertrophied cardiac ventricles induced by triiodothyronine treatment in the rat. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27643942&form=6&db=m Cardiac connexin-43 and PKC signaling in rats with altered thyroid status without and with omega-3 fatty acids intake. unassigned - 2.7.11.13 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31281590&form=6&db=m Oxidative Stress Produced by Hyperthyroidism Status Induces the Antioxidant Enzyme Transcription through the Activation of the Nrf-2 Factor in Lymphoid Tissues of Balb/c Mice. causal interaction,unassigned 1,0 2.7.11.13 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523399&form=6&db=m Potential role of glycerol leading to rat fructose hypertension. therapeutic application,unassigned 1,0 2.7.11.13 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8264660&form=6&db=m Phorbol ester stimulates the synthesis and secretion of brain natriuretic peptide from neonatal rat ventricular cardiocytes: a comparison with the regulation of atrial natriuretic factor. unassigned - 2.7.11.13 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9220354&form=6&db=m Protein kinase C activity and expression in rabbit left ventricular hypertrophy. ongoing research,unassigned 4,0 2.7.11.13 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256480&form=6&db=m Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12619877&form=6&db=m Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15532718&form=6&db=m Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. causal interaction,unassigned 3,0 2.7.11.13 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594058&form=6&db=m Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18837353&form=6&db=m [Effect of tashinone on nitric oxide synthase in hypertrophic cadiocyte of rats suffered abdominal aorta constriction] ongoing research,unassigned 2,0 2.7.11.13 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237166&form=6&db=m Differential regulation of cardiac protein kinase C isozyme expression after aortic banding in rat. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15532718&form=6&db=m Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. causal interaction,unassigned 3,0 2.7.11.13 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19995357&form=6&db=m Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765942&form=6&db=m Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Hypocalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21135065&form=6&db=m A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia. causal interaction,unassigned 1,0 2.7.11.13 Hypocalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26160055&form=6&db=m Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A. causal interaction,unassigned 4,0 2.7.11.13 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8490715&form=6&db=m Brain protein kinase C assay using MARCKS substrate reveals no translocation due to profound insulin-induced hypoglycemia. ongoing research,unassigned 3,0 2.7.11.13 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8588822&form=6&db=m Phorbol ester alters the electrophysiological responses to hypoxia and ischemic-like conditions in the rat hippocampal slice. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721728&form=6&db=m Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line. unassigned - 2.7.11.13 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17341624&form=6&db=m c-Jun and JunB are essential for hypoglycemia-mediated VEGF induction. therapeutic application,unassigned 1,0 2.7.11.13 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32950484&form=6&db=m Hypoglycemia increases endothelial-dependent vasodilation through suppressing phosphorylation at Threonine 495/497 site of endothelial nitric oxide synthase. therapeutic application,unassigned 1,0 2.7.11.13 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502583&form=6&db=m A Comprehensive Review of Erectile Dysfunction in Men with Diabetes. causal interaction,unassigned 4,0 2.7.11.13 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16987344&form=6&db=m Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle. unassigned - 2.7.11.13 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644073&form=6&db=m Ca++ influx is essential for the hypotensive response to arginine vasopressin-induced neuron activation of the area postrema in the rat. causal interaction,unassigned 1,0 2.7.11.13 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2037057&form=6&db=m Effect of hypothyroidism and thyroid hormone replacement on the level of protein kinase C and protein kinase A in rat liver. ongoing research,unassigned 4,0 2.7.11.13 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3004918&form=6&db=m Regulation of thyroxine 5'-deiodinase by thyroid hormones and activators of protein kinase C in GH4C1 cells. therapeutic application,unassigned 1,0 2.7.11.13 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8344193&form=6&db=m Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase-C substrate. ongoing research,unassigned 2,0 2.7.11.13 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8726960&form=6&db=m Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats. ongoing research,unassigned 1,0 2.7.11.13 Hypoxia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16972836&form=6&db=m Severe withdrawal syndrome in three newborns subjected to continuous opioid infusion and seizure activity dependent on brain hypoxia - ischemia. A possible link. causal interaction,unassigned 4,0 2.7.11.13 Ichthyosis, Lamellar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547380&form=6&db=m Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11778502&form=6&db=m [Changes on the protein kinase C activity of alveolar macrophages in patients with idiopathic pulmonary fibrosis] causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11780323&form=6&db=m Increased activity of protein kinase C in alveolar macrophages in idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Ileitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17765238&form=6&db=m Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons. ongoing research,unassigned 4,0 2.7.11.13 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473184&form=6&db=m Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410238&form=6&db=m Protein kinase C isozymes as potential therapeutic targets in immune disorders. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22348094&form=6&db=m PKC Theta Ablation Improves Healing in a Mouse Model of Muscular Dystrophy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24892801&form=6&db=m Protein kinase C inhibitors for immune disorders. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8815904&form=6&db=m Specific induction of protein kinase C delta subspecies after transient middle cerebral artery occlusion in the rat brain: inhibition by MK-801. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723183&form=6&db=m Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats. ongoing research,unassigned 3,0 2.7.11.13 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350602&form=6&db=m DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. therapeutic application,unassigned 2,0 2.7.11.13 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21318404&form=6&db=m Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood-Brain Barrier in a Focal Cerebral Ischemic Insult. therapeutic application,unassigned 1,0 2.7.11.13 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24004847&form=6&db=m Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia. ongoing research,unassigned 4,0 2.7.11.13 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30872361&form=6&db=m Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=170098&form=6&db=m Protein kinase of bacteriophage T7. 1. Purification. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1101258&form=6&db=m In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1351090&form=6&db=m Reduced susceptibility to HIV-1 infection of ethyl-methanesulfonate-treated CEM subclones correlates with a blockade in their protein kinase C signaling pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910000&form=6&db=m Inhibition of Ehrlichia risticii infection in murine peritoneal macrophages by gamma interferon, a calcium ionophore, and concanavalin A. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2041083&form=6&db=m Characterization of Pichinde virus infection of cells of the monocytic lineage. causal interaction,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2059960&form=6&db=m Regulatory effects of persistent measles virus infection on tumorigenicity and protooncogene expression in neuroblastoma cells. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2591531&form=6&db=m Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2600088&form=6&db=m Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1). therapeutic application,unassigned 3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2666979&form=6&db=m The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis. causal interaction,unassigned 4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848895&form=6&db=m Activation and infection of B cells by Epstein-Barr virus. Role of calcium mobilization and of protein kinase C translocation. ongoing research,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7664753&form=6&db=m Leishmanial protein kinase C modulates host cell infection via secreted acid phosphatase. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980013&form=6&db=m Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8822807&form=6&db=m Leishmania donovani attachment stimulates PKC-mediated oxidative events in bone marrow-derived macrophages. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8880383&form=6&db=m Growth inhibition of herpes simplex virus-type 1 in calphostin C-treated astrocytes. ongoing research,unassigned 4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9057662&form=6&db=m Modulation of protein kinase C activity in Plasmodium falciparum-infected erythrocytes. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9143270&form=6&db=m Viral persistent infection affects both transcriptional and posttranscriptional regulation of neuron-specific molecule GAP43. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175259&form=6&db=m Activation of protein kinase C enhances the infection of endothelial cells by human cytomegalovirus. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9185603&form=6&db=m Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9394726&form=6&db=m Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9529117&form=6&db=m Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major. ongoing research,unassigned 3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9617893&form=6&db=m New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9788816&form=6&db=m Protein kinase C activation and vacuolation in HeLa cells invaded by Mycoplasma penetrans. ongoing research,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10553077&form=6&db=m Role of protein kinase C-alpha in the control of infection by intracellular pathogens in macrophages. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10731683&form=6&db=m Macrophage protein kinase C: its role in modulating membrane microviscosity and superoxide in leishmanial infection. ongoing research,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952587&form=6&db=m Sodium stibogluconate (Pentostam) potentiates oxidant production in murine visceral leishmaniasis and in human blood. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10992464&form=6&db=m Transforming growth factor beta1 ameliorates intestinal epithelial barrier disruption by Cryptosporidium parvum in vitro in the absence of mucosal T lymphocytes. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278339&form=6&db=m Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. ongoing research,unassigned 3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11290600&form=6&db=m Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus. therapeutic application,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375661&form=6&db=m Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376624&form=6&db=m Increased basal contractility of cardiomyocytes overexpressing protein kinase C epsilon and blunted positive inotropic response to endothelin-1. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11701615&form=6&db=m Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11927579&form=6&db=m Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. causal interaction,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12350143&form=6&db=m Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. ongoing research,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12477851&form=6&db=m Role of protein kinase C betaII in influenza virus entry via late endosomes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12502866&form=6&db=m Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594210&form=6&db=m Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12719581&form=6&db=m Role of the serine-threonine kinase PAK-1 in myxoma virus replication. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829844&form=6&db=m Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12878215&form=6&db=m Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12900386&form=6&db=m PKC zeta participates in activation of inflammatory response induced by enteropathogenic E. coli. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12952950&form=6&db=m Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500469&form=6&db=m Kinome analysis of host response to mycobacterial infection: a novel technique in proteomics. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14671092&form=6&db=m Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15016818&form=6&db=m Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. therapeutic application,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15184055&form=6&db=m Proteomic analysis reveals a role for protein kinase C-alpha in phagosome maturation. causal interaction,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210825&form=6&db=m Rac and protein kinase C-delta regulate ERKs and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in mast cells. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313379&form=6&db=m PKC-zeta is essential for endotoxin-induced macrophage activation. causal interaction,unassigned 3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322029&form=6&db=m Encapsulated Streptococcus suis inhibits activation of signaling pathways involved in phagocytosis. causal interaction,unassigned 4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362041&form=6&db=m Differing roles of protein kinase C-zeta in disruption of tight junction barrier by enteropathogenic and enterohemorrhagic Escherichia coli. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15536414&form=6&db=m Protein kinase Cdelta functions downstream of Ca2+ mobilization in FcepsilonRI signaling to degranulation in mast cells. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15564481&form=6&db=m Protein kinase C-alpha activity is required for respiratory syncytial virus fusion to human bronchial epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15578063&form=6&db=m Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182255&form=6&db=m Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299331&form=6&db=m Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352573&form=6&db=m Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474437&form=6&db=m Characterization of the antiviral effects of interferon-alpha against a SARS-like coronoavirus infection in vitro. ongoing research,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513304&form=6&db=m Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622018&form=6&db=m Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase. therapeutic application,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16782696&form=6&db=m Rapid activation of Na+/H+ exchange by EPEC is PKC mediated. causal interaction,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846783&form=6&db=m Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16925784&form=6&db=m Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16989610&form=6&db=m HIV Type 1 Inhibition by Protein Kinase C Modulatory Compounds. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210830&form=6&db=m Mechanism of endothelial nitric oxide synthase phosphorylation and activation by thrombin. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17227757&form=6&db=m Human biliverdin reductase, a previously unknown activator of protein kinase C betaII. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17235316&form=6&db=m EGF receptor activation decreases retroviral gene transfer through protein kinase C-delta. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17346313&form=6&db=m Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17507466&form=6&db=m Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but dispensable for binding and entry. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653813&form=6&db=m Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17964626&form=6&db=m Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042254&form=6&db=m Parvovirus interference with intracellular signalling: mechanism of PKCeta activation in MVM-infected A9 fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18184679&form=6&db=m Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18296444&form=6&db=m Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. therapeutic application,unassigned 4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18489726&form=6&db=m Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606523&form=6&db=m Outer membrane protein A expression in Enterobacter sakazakii is required to induce microtubule condensation in human brain microvascular endothelial cells for invasion. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19175182&form=6&db=m Immunochemical localization of protein kinase Calpha in the biopsies of human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19185618&form=6&db=m Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19286978&form=6&db=m Ubiquitination Participates in the Lysosomal Degradation of the Na,K-ATPase in Steady-State Conditions. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321616&form=6&db=m Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19437514&form=6&db=m Helicobacter pylori activates protein kinase C delta to control Raf in MAP kinase signalling: Role in AGS epithelial cell scattering and elongation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19854265&form=6&db=m Puerarin Attenuates High Glucose and Diabetes-induced Vascular Smooth Muscle Cell Proliferation Via Blocking PKC-beta2/Rac-1-Dependent Signaling. causal interaction,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19907075&form=6&db=m PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. therapeutic application,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19949911&form=6&db=m Expression of Protein Kinase C Family in Human Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20030858&form=6&db=m Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG. causal interaction,unassigned 3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237079&form=6&db=m Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398184&form=6&db=m Trichinella spiralis infection enhances protein kinase C phosphorylation in guinea pig alveolar macrophages. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633125&form=6&db=m Enhanced expression of glycine N-methyltransferase by adenovirus-mediated gene transfer in CNS culture is neuroprotective. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20640460&form=6&db=m A proteomic analysis of PKCepsilon targets in astrocytes: implications for astrogliosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21124804&form=6&db=m Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21331522&form=6&db=m Viral interference with neuronal integrity: what can we learn from the Borna disease virus? unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21486607&form=6&db=m Frontiers in immunosuppression. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21666058&form=6&db=m Protein kinase C and NF-?B-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22196854&form=6&db=m Emerging cellular targets for influenza antiviral agents. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442164&form=6&db=m Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993156&form=6&db=m Rift Valley fever virus strain MP-12 enters mammalian host cells via caveola-mediated endocytosis. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23612054&form=6&db=m MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23740983&form=6&db=m Echovirus 1 entry into polarized Caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100262&form=6&db=m Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24205826&form=6&db=m Identification of novel human kinases that suppress hepatitis C virus infection. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24491575&form=6&db=m Protein Kinase C Mediates Enterohemorrhagic Escherichia coli O157:H7-Induced Attaching and Effacing Lesions. ongoing research,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24957217&form=6&db=m Exogenous and endogenous hyaluronic acid reduces HIV infection of CD4(+) T cells. therapeutic application,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25544312&form=6&db=m Arabinosylated lipoarabinomannan (Ara-LAM) mediated intracellular mechanisms against tuberculosis infection: Involvement of protein kinase C (PKC) mediated signaling. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963564&form=6&db=m Prostratin: An Overview. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26043820&form=6&db=m Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26152710&form=6&db=m Role of protein kinase C in cytokine secretion by lung epithelial cells during infection with Paracoccidioides brasiliensis. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26664962&form=6&db=m A Role for the Non-Canonical Wnt-?-Catenin and TGF-? Signaling Pathways in the Induction of Tolerance during the Establishment of a Salmonella enterica Serovar Enteritidis Persistent Cecal Infection in Chickens. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26757826&form=6&db=m Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465248&form=6&db=m Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590028&form=6&db=m Spring viraemia of carp virus enters grass carp ovary cells via clathrin-mediated endocytosis and macropinocytosis. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27700064&form=6&db=m Protein kinase C Signaling in Adenoviral Infection. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28175946&form=6&db=m Integrin beta and receptor for activated protein kinase C are involved in the cell entry of Bombyx mori cypovirus. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539656&form=6&db=m PKC-? isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-?B and CXCL8 production. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30123426&form=6&db=m Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30612517&form=6&db=m Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. unassigned - 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30723184&form=6&db=m Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30917487&form=6&db=m The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation. causal interaction,unassigned 4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31049989&form=6&db=m Salmon cells SHK-1 internalize infectious pancreatic necrosis virus by macropinocytosis. therapeutic application,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31455656&form=6&db=m CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31647538&form=6&db=m Chlamydia trachomatis recruits protein kinase C during infection. ongoing research,unassigned 1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31740529&form=6&db=m The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes. causal interaction,unassigned 2,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31890865&form=6&db=m Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKC? Activation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570748&form=6&db=m Chitosan inhibits septin-mediated plant infection by the rice blast fungus Magnaporthe oryzae in a protein kinase C and Nox1 NADPH oxidase-dependent manner. therapeutic application,unassigned 1,0 2.7.11.13 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100262&form=6&db=m Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258705&form=6&db=m PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100262&form=6&db=m Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26306493&form=6&db=m ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. causal interaction,unassigned 3,0 2.7.11.13 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12235228&form=6&db=m Activation of delta-isoform of protein kinase C is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epithelia. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18155708&form=6&db=m Protein kinase C theta plays a fundamental role in different types of chronic colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19689371&form=6&db=m Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698925&form=6&db=m Inhibitory effect of protein kinase C inhibitor on the replication of influenza type A virus. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2778438&form=6&db=m Differential phosphorylation of the nucleoprotein of influenza A viruses. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713939&form=6&db=m Characterization of a protein kinase C-delta (PKC-delta) ATP binding mutant. An inactive enzyme that competitively inhibits wild type PKC-delta enzymatic activity. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9794800&form=6&db=m Reversible penetration of alpha-glutathione S-transferase into biological membranes revealed by photosensitized labelling in situ. therapeutic application,unassigned 1,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9856090&form=6&db=m Influenza virus hemagglutinin stimulates the protein kinase C activity of human polymorphonuclear leucocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799781&form=6&db=m The influenza A virus M1 protein interacts with the cellular receptor of activated C kinase (RACK) 1 and can be phosphorylated by protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10920189&form=6&db=m Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia. unassigned - 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11038382&form=6&db=m Entry of influenza viruses into cells is inhibited by a highly specific protein kinase C inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12466482&form=6&db=m Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells. therapeutic application,unassigned 2,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12477851&form=6&db=m Role of protein kinase C betaII in influenza virus entry via late endosomes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579900&form=6&db=m Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. unassigned - 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15959836&form=6&db=m Characterization of the host cell entry of filamentous influenza virus. unassigned - 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16624496&form=6&db=m A nutritional supplement formula for influenza A (H5N1) infection in humans. causal interaction,unassigned 4,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18585796&form=6&db=m Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity. unassigned - 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19264651&form=6&db=m The influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21253874&form=6&db=m Host cellular signaling induced by influenza virus. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28758638&form=6&db=m Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336404&form=6&db=m The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1756911&form=6&db=m Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance. ongoing research,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540178&form=6&db=m Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate breakdown in liver from humans with and without type II diabetes. causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2649084&form=6&db=m Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3282940&form=6&db=m Minimal effects of phorbol esters on glucose transport and insulin sensitivity of rat skeletal muscle. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3803738&form=6&db=m Identification of a major defect in insulin-resistant tissues of genetically obese (fa/fa) rats. Impaired protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7988419&form=6&db=m Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructose-induced insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088704&form=6&db=m Biochemical mechanisms of insulin resistance. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8320278&form=6&db=m Protein kinase C: mediator or inhibitor of insulin action? causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8454604&form=6&db=m Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670164&form=6&db=m Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8826977&form=6&db=m Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943287&form=6&db=m Transcriptional regulation of insulin receptor substrate 1 by protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9000691&form=6&db=m Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9039952&form=6&db=m Regulation of expression of the rodent cytosolic sulfotransferases. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9324113&form=6&db=m Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle? causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9335553&form=6&db=m Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9374677&form=6&db=m Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653. causal interaction,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493493&form=6&db=m Mechanisms of insulin resistance and new pharmacological approaches to metabolism and diabetic complications. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9617893&form=6&db=m New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9686926&form=6&db=m Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9781332&form=6&db=m Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. causal interaction,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9818205&form=6&db=m Protein kinases C: potential targets for intervention in diabetic nephropathy. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10052864&form=6&db=m Complementary measures for promoting insulin sensitivity in skeletal muscle. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10342815&form=6&db=m Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10429471&form=6&db=m [Pathophysiology of vascular complications in diabetes] causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499500&form=6&db=m Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600797&form=6&db=m Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710511&form=6&db=m Protein kinase C modulates insulin action in human skeletal muscle. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919262&form=6&db=m Protein kinase Ctheta expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Ctheta in insulin-stimulated glycogen synthase activity. causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10923637&form=6&db=m Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10938109&form=6&db=m Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells. ongoing research,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995595&form=6&db=m Effects of tumour necrosis factor-alpha and inhibition of protein kinase C on glucose uptake in L6 myoblasts. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032731&form=6&db=m The role of atypical and conventional PKC in dehydroepiandrosterone-induced glucose uptake and dexamethasone-induced insulin resistance. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11052977&form=6&db=m Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11246878&form=6&db=m Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11282455&form=6&db=m Glucocorticoid-induced insulin resistance associates with activation of protein kinase C isoforms. ongoing research,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375323&form=6&db=m Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11404218&form=6&db=m Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11440359&form=6&db=m Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795838&form=6&db=m Albert Renold memorial lecture: molecular background of nutritionally induced insulin resistance leading to type 2 diabetes--from animal models to humans. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11915930&form=6&db=m Mechanisms of muscle insulin resistance in obese individuals. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11916925&form=6&db=m Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12079834&form=6&db=m Hyperglycemia and insulin resistance: possible mechanisms. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12079844&form=6&db=m Protein kinase C and lipid-induced insulin resistance in skeletal muscle. therapeutic application,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086926&form=6&db=m Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. causal interaction,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217885&form=6&db=m Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12372842&form=6&db=m Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12409308&form=6&db=m Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524657&form=6&db=m Inhibitory effect of ceramide on insulin-induced protein kinase Czeta translocation in rat adipocytes. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12546685&form=6&db=m Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586357&form=6&db=m Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606527&form=6&db=m Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665248&form=6&db=m Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740011&form=6&db=m Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle. causal interaction,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12790799&form=6&db=m Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12864742&form=6&db=m The role of intramuscular lipid in insulin resistance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866995&form=6&db=m Free fatty acids, insulin resistance, and pregnancy. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12962693&form=6&db=m Nutritional effects of fat on carbohydrate metabolism. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14583092&form=6&db=m Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14636302&form=6&db=m Increased skeletal muscle expression of PKC-theta but not PKC-alpha mRNA in type 2 diabetes: inverse relationship with in-vivo insulin sensitivity. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15053989&form=6&db=m Phorbol esters affect skeletal muscle glucose transport in a fiber type-specific manner. therapeutic application,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15143153&form=6&db=m Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15166226&form=6&db=m Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. therapeutic application,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15168016&form=6&db=m Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta. causal interaction,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576967&form=6&db=m [Effects of calcium channel blockers in atherosclerosis and cardiovascular event and oxidative vascular damage] causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607575&form=6&db=m De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637306&form=6&db=m Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649404&form=6&db=m PKCepsilon induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15787604&form=6&db=m Atypical protein kinase C in insulin action and insulin resistance. therapeutic application,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823720&form=6&db=m AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome. causal interaction,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963387&form=6&db=m Alcohol and the cardiovascular system research challenges and opportunities. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16046301&form=6&db=m Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16117322&form=6&db=m Effects of tumor necrosis factor-alpha on insulin stimulated amino acid transport in cultured rat hepatocytes. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309849&form=6&db=m Induction of heat shock proteins may combat insulin resistance. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505232&form=6&db=m Activation of Vascular Protein Kinase C-{beta} Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16545776&form=6&db=m PKCtheta is a key player in the development of insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16896164&form=6&db=m Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16903823&form=6&db=m Protein kinase Czeta and glucose uptake. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062841&form=6&db=m CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130651&form=6&db=m Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17272392&form=6&db=m Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17318260&form=6&db=m Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332526&form=6&db=m Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369525&form=6&db=m Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17446166&form=6&db=m Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17491114&form=6&db=m Leptin, skeletal muscle lipids, and lipid-induced insulin resistance. diagnostic usage,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17526931&form=6&db=m Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17823764&form=6&db=m Effect of dehydroepiandrosterone on insulin sensitivity in Otsuka Long-Evans Tokushima-fatty rats. ongoing research,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906635&form=6&db=m Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17911348&form=6&db=m Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940018&form=6&db=m Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18086904&form=6&db=m Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18196982&form=6&db=m Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18207474&form=6&db=m Muscular diacylglycerol metabolism and insulin resistance. causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18285345&form=6&db=m Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. causal interaction,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18358236&form=6&db=m Links between enhanced fatty acid flux, protein kinase C and NFkappaB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance. ongoing research,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18370676&form=6&db=m Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18402935&form=6&db=m Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18500676&form=6&db=m A high-fructose diet impairs Akt and PKCzeta phosphorylation and GLUT4 translocation in rat skeletal muscle. causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18535477&form=6&db=m Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18543263&form=6&db=m Updating the effects of fatty acids on skeletal muscle. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955497&form=6&db=m In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022218&form=6&db=m PKCepsilon plays a causal role in acute ethanol-induced steatosis. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047061&form=6&db=m Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124171&form=6&db=m Classical PKC is not associated with defective insulin signaling in patients with impaired glucose tolerance. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19153269&form=6&db=m Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19259639&form=6&db=m Elovl6: a new player in fatty acid metabolism and insulin sensitivity. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19308256&form=6&db=m Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19357831&form=6&db=m Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19413892&form=6&db=m Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519579&form=6&db=m PKC delta and epsilon in drug targeting and therapeutics. therapeutic application,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809797&form=6&db=m Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19929130&form=6&db=m Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130736&form=6&db=m Renoprotective and blood pressure-lowering effect of dietary soy protein via protein kinase C betaII inhibition in a rat model of metabolic syndrome. ongoing research,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200319&form=6&db=m Glycerol-3-phosphate acyltransferase 1-deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20425233&form=6&db=m Therapeutic strategies for diabetic neuropathy. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20569275&form=6&db=m Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620996&form=6&db=m PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20692055&form=6&db=m Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-kappaB pathway in rat aorta. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21136963&form=6&db=m Sensing the insulin signaling pathway with an antibody array. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21153149&form=6&db=m Tissue-dependent activation of protein kinase C in fructose-induced insulin resistance. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21176778&form=6&db=m Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21179305&form=6&db=m Coronary microvascular dysfunction in diabetes mellitus: A review. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21246399&form=6&db=m Is prenatal myo-inositol deficiency a mechanism of CNS injury in galactosemia? causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21451535&form=6&db=m Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21550971&form=6&db=m Disruption of the murine protein kinase Cbeta gene promotes gallstone formation and alters biliary lipid and hepatic cholesterol metabolism. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635764&form=6&db=m Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats. ongoing research,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21835020&form=6&db=m Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes. ongoing research,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21933341&form=6&db=m pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22046423&form=6&db=m Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C ? and ?. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22191431&form=6&db=m Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22304840&form=6&db=m A brief history of insulin resistance: from the first insulin radioimmunoassay to selectively targeting protein kinase C pathways. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22881371&form=6&db=m Monounsaturated fatty acids are required for membrane translocation of protein kinase C-theta induced by lipid overload in skeletal muscle. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23454694&form=6&db=m Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23775122&form=6&db=m Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24206666&form=6&db=m Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. ongoing research,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595352&form=6&db=m Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24720596&form=6&db=m The Impact of Substance P on the Pathogenesis of Insulin Resistance Leading to Gestational Diabetes. therapeutic application,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25395359&form=6&db=m Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25467844&form=6&db=m In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26007287&form=6&db=m DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237474&form=6&db=m Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26273583&form=6&db=m Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance? causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26307588&form=6&db=m Role of PKC? in Insulin Sensitivity and Skeletal Muscle Metabolism. causal interaction,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26386696&form=6&db=m BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1? in livers of obese and type 2 diabetic humans. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26408801&form=6&db=m Molecular and cellular mechanisms linking inflammation to insulin resistance and ?-cell dysfunction. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26519157&form=6&db=m A bis-Schiff base of isatin improves methylglyoxal mediated insulin resistance in skeletal muscle cells. causal interaction,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26660890&form=6&db=m Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. ongoing research,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26868297&form=6&db=m PKC-? is essential for pancreatic beta cell replication during insulin resistance by regulating mTOR and cyclin-D2. ongoing research,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28585204&form=6&db=m Insulin Resistance, Obesity and Lipotoxicity. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28739087&form=6&db=m Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance. therapeutic application,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29233519&form=6&db=m Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances ?-cell function of obese Zucker rats. therapeutic application,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29728363&form=6&db=m Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30409037&form=6&db=m Type-2 diabetes mellitus and cardiovascular disease. causal interaction,unassigned 4,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30540820&form=6&db=m Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. ongoing research,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692925&form=6&db=m Potential Nexus of Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Insulin Resistance Between Hepatic and Peripheral Tissues. causal interaction,unassigned 2,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31108350&form=6&db=m Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice. therapeutic application,unassigned 3,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31220350&form=6&db=m Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ?. causal interaction,unassigned 1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31387939&form=6&db=m The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32305097&form=6&db=m Deconstructing the Role of PKC Epsilon in Glucose Homeostasis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33123598&form=6&db=m Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications. unassigned - 2.7.11.13 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34222094&form=6&db=m Inflammatory biomarkers as a part of diagnosis in diabetic peripheral neuropathy. causal interaction,unassigned 1,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695486&form=6&db=m Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells. ongoing research,unassigned 4,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153524&form=6&db=m Different expression of protein kinase C isozymes in pancreatic islet cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2565041&form=6&db=m Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP. ongoing research,unassigned 1,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836174&form=6&db=m Dual action of protein kinase C activation in the regulation of insulin release by muscarinic agonist from rat insulinoma cell line (RINr). ongoing research,unassigned 4,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6331410&form=6&db=m Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein. ongoing research,unassigned 3,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7517367&form=6&db=m Expression, intracellular localization, and gene transcription regulation of the secretory protein 7B2 in endocrine pancreatic cell lines and human insulinomas. ongoing research,unassigned 1,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8070382&form=6&db=m Identification and subcellular characterization of protein kinase-C isoforms in insulinoma beta-cells and whole islets. ongoing research,unassigned 2,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408643&form=6&db=m Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8706914&form=6&db=m Up-regulation of L- and non-L, non-N-type Ca2+ channels by basal and stimulated protein kinase C activation in insulin-secreting RINm5F cells. ongoing research,unassigned 4,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8825422&form=6&db=m Regulation of distinct pools of protein kinase C delta in beta cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8903097&form=6&db=m Regulation of glucagon-like peptide-I receptor expression and transcription by the protein kinase C pathway. ongoing research,unassigned 4,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8928738&form=6&db=m Effects of secretagogues on insulin biosynthesis and secretion in polyamine-depleted pancreatic beta-cells. unassigned - 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9844735&form=6&db=m Glucose- and phorbol ester-induced insulin secretion in human insulinoma cells--association with protein kinase C activation. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10633227&form=6&db=m Effect of estradiol on insulin secreting INS-1 cells overexpressing estrogen receptors. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854558&form=6&db=m Effect of protein kinase C on glucose-mediated insulin secretion in HIT-T15 cells. ongoing research,unassigned 3,0 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849455&form=6&db=m Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase C beta II and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells. unassigned - 2.7.11.13 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19757495&form=6&db=m PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system. ongoing research,unassigned 4,0 2.7.11.13 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22445342&form=6&db=m The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. causal interaction,unassigned 1,0 2.7.11.13 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166186&form=6&db=m CK8 phosphorylation induced by compressive loads underlies the downregulation of CK8 in human disc degeneration by activating protein kinase C. unassigned - 2.7.11.13 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32564456&form=6&db=m Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C. therapeutic application,unassigned 2,0 2.7.11.13 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24312401&form=6&db=m PKC? signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells. ongoing research,unassigned 2,0 2.7.11.13 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232344&form=6&db=m PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30552022&form=6&db=m Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Iron Deficiencies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1951169&form=6&db=m Impaired protein kinase C activation as one of the possible mechanisms of reduced lymphocyte proliferation in iron deficiency in mice. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Iron Deficiencies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10412047&form=6&db=m In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells. ongoing research,unassigned 4,0 2.7.11.13 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2031710&form=6&db=m Post- and presynaptic lesions in the CA1 region of hippocampus: effect on [3H]forskolin and [3H]phorboldibutyrate ester binding. ongoing research,unassigned 3,0 2.7.11.13 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898399&form=6&db=m Post-ischemic changes in protein kinase C RNA in the gerbil brain following prolonged periods of recirculation: a phosphorimaging study. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7958073&form=6&db=m Protein kinase C-like immunoreactivity in gerbil hippocampus after a transient cerebral ischemia. unassigned - 2.7.11.13 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8051550&form=6&db=m Regional alterations of protein kinase C activity following transient cerebral ischemia: effects of intraischemic brain temperature modulation. unassigned - 2.7.11.13 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553692&form=6&db=m Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia. ongoing research,unassigned 3,0 2.7.11.13 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12950452&form=6&db=m Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor. unassigned - 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9583183&form=6&db=m Protein kinase C expression and activity in the human brain after ischaemic stroke. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19520989&form=6&db=m The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population. causal interaction,unassigned 3,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22044875&form=6&db=m Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22808203&form=6&db=m The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22840750&form=6&db=m Activation of protein kinase C isozymes for the treatment of dementias. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24534126&form=6&db=m Impact of the 1425G/A Polymorphism of PRKCH on the Recurrence of Ischemic Stroke: Fukuoka Stroke Registry. causal interaction,unassigned 3,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25114088&form=6&db=m Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27094771&form=6&db=m Suppression of PKC-? attenuates TNF-?-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016727&form=6&db=m cPKC? alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice. causal interaction,unassigned 4,0 2.7.11.13 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1577738&form=6&db=m Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters. Altered response is accompanied by reduced sensitivity to prostaglandin E2 and altered down-regulation of phorbol ester binding sites. causal interaction,unassigned 4,0 2.7.11.13 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974259&form=6&db=m Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306200&form=6&db=m PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Keratosis, Seborrheic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245514&form=6&db=m Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17014557&form=6&db=m Protein kinase C activation and its role in kidney disease. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20395372&form=6&db=m PKC-{delta} Promotes Renal Tubular Cell Apoptosis Associated with Proteinuria. causal interaction,unassigned 4,0 2.7.11.13 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21659759&form=6&db=m Advanced glycation end products. causal interaction,unassigned 2,0 2.7.11.13 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939814&form=6&db=m Oxidative Stress in Diabetic Nephropathy. causal interaction,unassigned 3,0 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627883&form=6&db=m Tumor necrosis factor mediates apoptosis via Ca++/Mg++ dependent endonuclease with protein kinase C as a possible mechanism for cytokine resistance in human renal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14562010&form=6&db=m A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer. unassigned - 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604996&form=6&db=m Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744756&form=6&db=m Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375568&form=6&db=m Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells. unassigned - 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18039096&form=6&db=m Von hippel-lindau disease. causal interaction,unassigned 4,0 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24500281&form=6&db=m PKC?/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells. ongoing research,unassigned 3,0 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166200&form=6&db=m Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target. therapeutic application,unassigned 2,0 2.7.11.13 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28565866&form=6&db=m Inhibition of PKC? reduces the ability of migration of kidney cancer cells but has no impact on cell apoptosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Lambert-Eaton Myasthenic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659349&form=6&db=m Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes. unassigned - 2.7.11.13 Laminopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142761&form=6&db=m Protein Kinase C Alpha Cellular Distribution, Activity, and Proximity with Lamin A/C in Striated Muscle Laminopathies. therapeutic application,unassigned 1,0 2.7.11.13 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20297679&form=6&db=m [Multidrug resistance increase of tumor cells at the effect of radiation and phorbol ether depends on protein kinase C and reactive oxygen species] ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24049167&form=6&db=m An HIV-1 replication pathway utilizing reverse transcript products that fail to integrate. therapeutic application,unassigned 4,0 2.7.11.13 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26043820&form=6&db=m Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Legionnaires' Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10553077&form=6&db=m Role of protein kinase C-alpha in the control of infection by intracellular pathogens in macrophages. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Legionnaires' Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19324950&form=6&db=m PKC{alpha} and {epsilon} differentially regulate Legionella pneumophila induced GM-CSF. unassigned - 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160843&form=6&db=m Involvement of annexin V in the antiproliferative effect of GnRH agonist on cultured human uterine leiomyoma cells. ongoing research,unassigned 4,0 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306908&form=6&db=m Differential regulation of protein kinase C isoforms in human uterine leiomyoma. ongoing research,unassigned 2,0 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331222&form=6&db=m Potentiation response of cultured human uterine leiomyoma cells to various growth factors by endothelin-1: role of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940248&form=6&db=m 7q deletion mapping and expression profiling in uterine fibroids. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19179429&form=6&db=m Human uterine smooth muscle and leiomyoma cells differ in their rapid 17beta-estradiol signaling: implications for proliferation. causal interaction,unassigned 1,0 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716167&form=6&db=m Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21400668&form=6&db=m DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.11.13 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553222&form=6&db=m The endothelin axis in uterine leiomyomas: new insights. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21400668&form=6&db=m DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.11.13 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9529117&form=6&db=m Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major. ongoing research,unassigned 3,0 2.7.11.13 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10464270&form=6&db=m MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63). causal interaction,unassigned 3,0 2.7.11.13 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18021365&form=6&db=m Induction of host protective Th1 immune response by chemokines in Leishmania donovani-infected BALB/c mice. unassigned - 2.7.11.13 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34021910&form=6&db=m TLR2 dimer-specific ligands selectively activate protein kinase C isoforms in Leishmania infection. unassigned - 2.7.11.13 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12704114&form=6&db=m Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody. unassigned - 2.7.11.13 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299331&form=6&db=m Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200403&form=6&db=m MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546775&form=6&db=m Amphotericin B regulates the host immune response in visceral leishmaniasis: reciprocal regulation of protein kinase C isoforms. unassigned - 2.7.11.13 Leishmaniasis, Visceral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24561457&form=6&db=m The curative effect of fucoidan on visceral leishmaniasis is mediated by activation of MAP kinases through specific protein kinase C isoforms. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1306325&form=6&db=m Protein kinase C activity in human leukemia cell lines with reference to sensitivity to antineoplastic agents. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1313698&form=6&db=m Synergistic stimulating effect between cyclic AMP and phorbol ester on plasminogen activator inhibitor type 2 production in human promyelocytic leukemia cell line PL-21. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318407&form=6&db=m Enhanced gene expression of the murine ecotropic retroviral receptor and its human homolog in proliferating cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322833&form=6&db=m Membrane interactions of mastoparan analogues related to their differential effects on protein kinase C, Na, K-ATPase and HL60 cells. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1323343&form=6&db=m Stimulation of phosphoinositol turnover and protein kinase C activation by granulocyte-macrophage colony-stimulating factor in HL-60 cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1381000&form=6&db=m Effects of inhibitors of protein kinase C on the release and synthesis of histamine in rat basophilic leukemia cells (2H3). ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1423273&form=6&db=m Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425005&form=6&db=m [A laboratory and clinical study of induced differentiation therapy by all trans-retinoic acid in acute promyelocytic leukemia] causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429228&form=6&db=m A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine). diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429868&form=6&db=m Bistratene A: a novel compound causing changes in protein phosphorylation patterns in human leukemia cells. ongoing research,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445803&form=6&db=m Protein kinase C beta gene expression is associated with susceptibility of human promyelocytic leukemia cells to phorbol ester-induced differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1493432&form=6&db=m Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1540240&form=6&db=m Activation of human leukemia protein kinase C by tumor promoters and its inhibition by N-trifluoroacetyladriamycin-14-valerate (AD 32). causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1549353&form=6&db=m Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559218&form=6&db=m In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium. therapeutic application,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1569050&form=6&db=m Retinoic acid-specific induction of a protein kinase C isoform during differentiation of HL-60 cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1635422&form=6&db=m Protein kinase C activity during sphinganine potentiation of retinoic acid-induced differentiation in a human leukemia cell line (HL-60). diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660353&form=6&db=m The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698561&form=6&db=m Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic leukemia cells: individual response patterns and their relationships with both maturation and protein kinase C content. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1714454&form=6&db=m Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones. causal interaction,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1746908&form=6&db=m Cremophor EL inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced protein phosphorylation in human myeloblastic leukemia ML-1 cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1776955&form=6&db=m dsDNA-stimulated phosphorylation of a 72-kDa nucleoprotein accompanies PMA-induced HL-60 leukemic cell differentiation. causal interaction,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1814434&form=6&db=m Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1825660&form=6&db=m Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1879193&form=6&db=m Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907849&form=6&db=m Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism. causal interaction,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1937587&form=6&db=m Rat basophilic leukemia cells: protein kinase C and secretion. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1952935&form=6&db=m Thrombin-induced translocation of protein kinase C in human megakaryoblastic leukemia cells (MEG-01). ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2001419&form=6&db=m Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2096263&form=6&db=m Differential regulation of protein kinase C subspecies in human promyelocytic leukemia cell line HL-60 during differentiation induced by retinoic acid. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2152929&form=6&db=m Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153047&form=6&db=m Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159369&form=6&db=m Inhibition of protein kinase C, (sodium plus potassium)-activated adenosine triphosphatase, and sodium pump by synthetic phospholipid analogues. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2165851&form=6&db=m Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2302237&form=6&db=m Protein kinase C-gamma is present in adriamycin resistant HL-60 leukemia cells. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2332050&form=6&db=m Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2394706&form=6&db=m Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2473073&form=6&db=m Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496761&form=6&db=m Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537141&form=6&db=m Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551964&form=6&db=m Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2567212&form=6&db=m Role of protein kinase C activators and inhibitors, calmodulin antagonists and membrane sialic acids in polyamine transport in murine leukemia cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2567674&form=6&db=m T cell activation via the CD2 molecule is associated with protein kinase C translocation from the cytosol to the plasma membrane. ongoing research,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2586142&form=6&db=m Studies on the relationship between protein kinase C and differentiation of human promyelocytic leukemia cells induced by retinoic acid. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2590208&form=6&db=m Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2705749&form=6&db=m Adriamycin interacts with diacylglycerol to inhibit human leukemia protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2715723&form=6&db=m Effects of inducers of differentiation on protein kinase C and CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activities of HL-60 leukemia cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2733239&form=6&db=m Effect of an inhibitory factor for protein kinase C on cell growth of leukemic cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2736522&form=6&db=m Elevation of intracellular calcium ion by prostaglandin E1 and its inhibition by protein kinase C in a human megakaryocyte leukemia cell line. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2752042&form=6&db=m Isolation and purification of protein kinase C from human leukemia ML-1 cells phosphorylation of human leukemia RNA polymerase II in vitro. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2765502&form=6&db=m Lipoprotein lipase gene expression in THP-1 cells. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2794509&form=6&db=m The rise in concentration of free Ca2+ and of pH provides sequential, synergistic signals for secretion in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834235&form=6&db=m Cooperative interactions of protein kinase C and cAMP-dependent protein kinase systems in human promyelocytic leukemia HL60 cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834348&form=6&db=m Involvement of two intracellular messenger systems, protein kinase C and cyclic AMP, in the regulation of c-fos gene expression in human promyelocytic leukemia (HL-60) cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835653&form=6&db=m Staurosporine inhibits protein kinase C and prevents phorbol ester-mediated leukotriene D4 receptor desensitization in RBL-1 cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837395&form=6&db=m Leukotriene D4-induced activation of protein kinase C in rat basophilic leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2917998&form=6&db=m Differential down-regulation of protein kinase C isozymes. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2987211&form=6&db=m Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011248&form=6&db=m Inhibition of chemotactic peptide-induced phosphoinositide hydrolysis by phorbol esters through the activation of protein kinase C in differentiated human leukemia (HL-60) cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034277&form=6&db=m Effects of the protein kinase C inhibitor H-7 and calmodulin antagonist W-7 on superoxide production in growing and resting human histiocytic leukemia cells (U937). ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099098&form=6&db=m Retinoic acid promotes phorbol ester-initiated macrophage differentiation in HL-60 leukemia cells without disappearance of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3112073&form=6&db=m Synthetic analogues (indolactams) of (-)-indolactam-V are new congeners of the teleocidin class of tumor promoters. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3114251&form=6&db=m Disparate effects of activators of protein kinase C on HL-60 promyelocytic leukemia cell differentiation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3130982&form=6&db=m Role of protein kinase C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137176&form=6&db=m Protein kinase C activators of the teleocidin family decrease the IgE-binding capacity of rat basophilic leukemia cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3160629&form=6&db=m Specificities of acylglycerols and phospholipids for interaction with phorbol ester receptor on Friend leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3162823&form=6&db=m Protein kinase C activities with different characteristics, including substrate specificity, from two human HL-60 leukemia cell variants. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3162885&form=6&db=m Temporal changes in intracellular distribution of protein kinase C during differentiation of human leukemia HL60 cells induced by phorbol ester. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3165300&form=6&db=m Phospholipase C activates protein kinase C and induces monocytic differentiation of HL-60 cells. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3180076&form=6&db=m Effects of thioether phospholipid BM 41.440 on protein kinase C and phorbol ester-induced differentiation of human leukemia HL60 and KG-1 cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3325877&form=6&db=m Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60). causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422643&form=6&db=m Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3463970&form=6&db=m Translocation of protein kinase C in human leukemia cells susceptible or resistant to differentiation induced by phorbol 12-myristate 13-acetate. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3469014&form=6&db=m Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3475067&form=6&db=m Protein kinase C phosphorylates leukemia RNA polymerase II. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3957464&form=6&db=m Modulation of protein kinase C and Ca2+ lipid-independent protein kinase in lymphoma induced by Moloney murine leukemia virus in BALB/c mice. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4043397&form=6&db=m Rapid down-regulation of protein kinase C and membrane association in phorbol ester-treated leukemia cells. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7476909&form=6&db=m Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of beta II protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7509801&form=6&db=m Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511048&form=6&db=m Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7512966&form=6&db=m Human leukemia K562 cell mutant (K562/OA200) selected for resistance to okadaic acid (protein phosphatase inhibitor) lacks protein kinase C-epsilon, exhibits multidrug resistance phenotype, and expresses drug pump P-glycoprotein. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7548173&form=6&db=m Antigen-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium/calmodulin. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575560&form=6&db=m Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7637391&form=6&db=m The protein kinase C inhibitor H7 blocks phosphorylation of stathmin during TPA-induced growth inhibition of human pre-B leukemia REH6 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7718618&form=6&db=m Okadaic acid increased annexin I and induced differentiation of human promyelocytic leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7749199&form=6&db=m Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7779100&form=6&db=m Activation of membrane-bound phospholipase D by protein kinase C in HL60 cells: synergistic action of a small GTP-binding protein RhoA. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7925852&form=6&db=m Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7989341&form=6&db=m Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8004692&form=6&db=m Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters. ongoing research,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8034640&form=6&db=m Differential requirements for p21ras and protein kinase C in the regulation of neuronal gene expression by nerve growth factor and neurokines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8052650&form=6&db=m Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8063766&form=6&db=m Presence of a beta II protein kinase C-selective nuclear membrane activation factor in human leukemia cells. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8083228&form=6&db=m Protein kinase C-beta is required for macrophage differentiation of human HL-60 leukemia cells. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8135836&form=6&db=m Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8135859&form=6&db=m Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179019&form=6&db=m Cytokine-cytokine synergy and protein kinase C in the regulation of lung fibroblast leukemia inhibitory factor. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8250895&form=6&db=m Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380192&form=6&db=m The cholinergic stimulating effects of ciliary neurotrophic factor and leukemia inhibitory factor are mediated by protein kinase C. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8396466&form=6&db=m Phorbol myristate acetate-differentiated THP-1 cells display increased levels of MHC class I and class II mRNA and interferon-gamma-inducible tumoricidal activity. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8412301&form=6&db=m Different effects of the two protein kinase C activators bryostatin-1 and TPA on growth and differentiation of human monocytic leukemia cell lines. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8552204&form=6&db=m Phorbol ester (TPA)-induced differential modulation of cell surface antigens in human pluripotential leukemia (K-562) cell line: effects of protein kinase inhibitors with broad- and PKC selective inhibitory activity. ongoing research,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569755&form=6&db=m Protein kinase C beta from Friend erythroleukemia cells is associated with chromatin and DNA. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626522&form=6&db=m Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. causal interaction,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630092&form=6&db=m Effects of hydroquinone-type and phenolic antioxidants on calcium signals and degranulation of RBL-2H3 cells. ongoing research,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8703801&form=6&db=m Protein kinase C isozymes in human megakaryoblastic leukemia cell line, MEG-01: possible involvement of the isozymes in the differentiation process of MEG-01 cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8871296&form=6&db=m [The involvement of protein kinase C isozymes in activation of phospholipase D and secretion of serotonin in rat basophilic leukemia cells] diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8877408&form=6&db=m Phenylarsine oxide (PAO)-mediated activation of phospholipase D in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium and protein kinase C. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8893841&form=6&db=m Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943781&form=6&db=m Characterization of 17 beta-hydroxysteroid dehydrogenase IV. causal interaction,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8996546&form=6&db=m Stimulation of 1-(beta-D-arabinofuranosyl)cytosine (AraC)-induced apoptosis in the multidrug resistant human promyelocytic leukemia cell lines with protein kinase inhibitors. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8999958&form=6&db=m Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9070316&form=6&db=m Potentiation of the activity of nitric oxide by the protein kinase C activator phorbol ester in human myeloid leukemic HL-60 cells: association with enhanced fragmentation of mature genomic DNA. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9141489&form=6&db=m Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9145519&form=6&db=m Microbial extracellular glycolipid induction of differentiation and inhibition of the protein kinase C activity of human promyelocytic leukemia cell line HL60. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9178828&form=6&db=m Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9225067&form=6&db=m Protein kinase C is not necessary for transforming growth factor beta-induced growth-arrest in leukemia cell lines. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9337072&form=6&db=m Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344462&form=6&db=m Expression of protein kinase C-beta promotes the stimulatory effect of phorbol ester on phosphatidylethanolamine synthesis. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346882&form=6&db=m Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9374422&form=6&db=m Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9396780&form=6&db=m Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9535842&form=6&db=m Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572888&form=6&db=m Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9578715&form=6&db=m Cyclic adenosine monophosphate inhibits nitric oxide-induced apoptosis in human leukemic HL-60 cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657740&form=6&db=m Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase Calpha. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9677417&form=6&db=m Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721047&form=6&db=m Opposing regulatory effects of protein kinase C on the cAMP cascade in human HL-60 promyelocytic leukemia cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9744778&form=6&db=m Quaternary ammonium analogs of ether lipids inhibit the activation of protein kinase C and the growth of human leukemia cell lines. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9783732&form=6&db=m Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937). ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804619&form=6&db=m Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. therapeutic application,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9862721&form=6&db=m Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10073669&form=6&db=m NF-kappaB or AP-1-dependent reporter gene expression is not altered in human U937 cells exposed to power-line frequency magnetic fields. causal interaction,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403525&form=6&db=m Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10576597&form=6&db=m Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10622208&form=6&db=m Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. therapeutic application,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737257&form=6&db=m 12-O-tetradecanoyl phorbol 13-acetate, protein kinase C (PKC) activator, protects human leukemia HL-60 cells from taxol-induced apoptosis: possible role for extracellular signal-regulated kinase. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10918054&form=6&db=m Activation of protein kinase C induces nuclear translocation of RFX1 and down-regulates c-myc via an intron 1 X box in undifferentiated leukemia HL-60 cells. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11264178&form=6&db=m Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11299787&form=6&db=m Evidence that activation of MEK1,2/erk1,2 signal transduction pathway is necessary for calcitriol-induced differentiation of HL-60 cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11377378&form=6&db=m Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11426620&form=6&db=m Differential effects of the MDR1 (multidrug resistance) gene-activating agents on protein kinase C: evidence for redundancy of mechanisms of acquired MDR in leukemia cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509123&form=6&db=m Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961058&form=6&db=m Bryostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-x(L). ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105221&form=6&db=m Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12114412&form=6&db=m Phase I trial and correlative laboratory studies of bryostatin 1 (NSC 339555) and high-dose 1-B-D-arabinofuranosylcytosine in patients with refractory acute leukemia. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12183077&form=6&db=m Involvement of diverse protein kinase C isoforms in the differentiation of ML-1 human myeloblastic leukemia cells induced by the vitamin D3 analogue KH1060 and the phorbol ester TPA. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12435813&form=6&db=m Overexpression of protein kinase Czeta confers protection against antileukemic drugs by inhibiting the redox-dependent sphingomyelinase activation. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525479&form=6&db=m Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738674&form=6&db=m Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740906&form=6&db=m Involvement of PKC betaII in anti-proliferating action of a new antitumor compound gnidimacrin. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805378&form=6&db=m Activation of protein kinase C delta by all-trans-retinoic acid. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14533002&form=6&db=m Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14660006&form=6&db=m Differential involvement of protein kinase C in human promyelocytic leukemia cell differentiation enhanced by artemisinin. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670960&form=6&db=m Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729073&form=6&db=m Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14737078&form=6&db=m PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15223313&form=6&db=m Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15291360&form=6&db=m Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592506&form=6&db=m PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15634593&form=6&db=m [Effects of protein tyrosine kinase, protein tyrosine phosphatase and protein kinase C on the apoptosis of arsenic trioxide treated NB4 cells and human cortex neurons] ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767555&form=6&db=m Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845465&form=6&db=m Microarray and proteomics analyses of human intestinal epithelial cells treated with the Aeromonas hydrophila cytotoxic enterotoxin. causal interaction,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845901&form=6&db=m PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15896453&form=6&db=m Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells. therapeutic application,unassigned 1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16465244&form=6&db=m Modulation of the expression of Bcl-2 and related proteins in human leukemia cells by protein kinase C activators: relationship to effects on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16554308&form=6&db=m Chemical modification of santonin into a diacetoxy acetal form confers the ability to induce differentiation of human promyelocytic leukemia cells via the down-regulation of NF-kappaB DNA binding activity. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16569674&form=6&db=m A redundant role for PKC-epsilon in mast cell signaling and effector function. ongoing research,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16793752&form=6&db=m Expression of GTP-binding proteins and protein kinase C isozymes in platelet-like particles derived from megakaryoblastic leukemia cells (MEG-01). ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17013757&form=6&db=m 12-o-Tetradecanoylphorbol 13-acetate prevents baicalein-induced apoptosis via activation of protein kinase C and JNKs in human leukemia cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17286201&form=6&db=m PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17610064&form=6&db=m Mitochondrial anchoring of PKCalpha by PICK1 confers resistance to etoposide-induced apoptosis. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704652&form=6&db=m Cudraflavanone A purified from Cudrania tricuspidata induces apoptotic cell death of human leukemia U937 cells, at least in part, through the inhibition of DNA topoisomerase I and protein kinase C activity. ongoing research,unassigned 3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17878267&form=6&db=m Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18077363&form=6&db=m A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462800&form=6&db=m Impaired anti-leukemic immune response in PKCtheta-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18539531&form=6&db=m Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18604714&form=6&db=m Protein kinase C signalling in leukemia. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18780722&form=6&db=m PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201988&form=6&db=m Pivotal Advance: PKC{zeta} is required for migration of macrophages. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19907075&form=6&db=m PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. therapeutic application,unassigned 2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21086135&form=6&db=m Akt and PKC are involved not only in upregulation of telomerase activity but also in cell differentiation-related function via mTORC2 in leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544391&form=6&db=m Relation of protein kinase A and protein kinase C to signaling pathways of hematopoietic factors in leukemia cell lines. ongoing research,unassigned 4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566991&form=6&db=m Effect of 12-deoxyphorbol 13-phenylacetate on daunorubicin resistance and calcium-independent protein-kinase-C isozymes in drug-sensitive murine leukemia p388 cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22330070&form=6&db=m AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22366247&form=6&db=m Synergistic effect of PKC activation and actin filament disruption on carbonate apatite-facilitated lymphocyte transfection. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23284657&form=6&db=m Unique in vitro and in vivo thrombopoietic activities of ingenol 3,20 dibenzoate, a Ca(++)-independent protein kinase C isoform agonist. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693686&form=6&db=m Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904380&form=6&db=m Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28096297&form=6&db=m Frontline Science: Tumor necrosis factor-? stimulation and priming of human neutrophil granule exocytosis. unassigned - 2.7.11.13 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266138&form=6&db=m Corrigendum to "AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells" [Cell. Signal. 24 (2012) 1195-1207]. diagnostic usage,unassigned 3,0 2.7.11.13 Leukemia P388 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566925&form=6&db=m Expression of protein-kinase-C isozymes in multidrug-resistant murine leukemia p388/adr cells. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1318407&form=6&db=m Enhanced gene expression of the murine ecotropic retroviral receptor and its human homolog in proliferating cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1374394&form=6&db=m Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1386358&form=6&db=m Maturation of murine erythroleukemia cells committed to differentiation requires protein kinase C. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1423278&form=6&db=m Evidence that a novel human differentiation-inhibiting protein blocks the dimethyl sulfoxide-induced differentiation of erythroleukemia cells by inhibiting the activation of membrane protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429688&form=6&db=m A rise and fall in 1,2-diacylglycerol content signal hexamethylene bisacetamide-induced erythropoiesis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1472015&form=6&db=m Induction of leukotriene C4 synthase activity in differentiating human erythroleukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1522149&form=6&db=m Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1556009&form=6&db=m A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1568447&form=6&db=m Nuclear protein kinase C activity is decreased in Friend erythroleukemia cells induced to differentiate. causal interaction,unassigned 3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1643117&form=6&db=m The activation of inactive membrane-associated protein kinase C is associated with DMSO-induced erythroleukemia cell differentiation. causal interaction,unassigned 1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1729681&form=6&db=m Protein kinase C isozymes epsilon and alpha in murine erythroleukemia cells. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1913849&form=6&db=m In vitro phosphorylation of lamin B by protein kinase C in friend erythroleukemia. Effect of chemically induced differentiation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2244886&form=6&db=m Identification of a protein kinase C activating factor from murine erythroleukemia cells: characterization of the activation kinetics. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2257884&form=6&db=m Enhanced expression of the beta II subspecies of protein kinase C in differentiating erythroleukemia cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2352925&form=6&db=m Introduction of the beta isozyme of protein kinase C accelerates induced differentiation of murine erythroleukemia cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2808382&form=6&db=m Differential expression of protein kinase C isozymes and erythroleukemia cell differentiation. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3469000&form=6&db=m Changes in protein kinase C activity are associated with the differentiation of Friend erythroleukemia cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3474654&form=6&db=m Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741754&form=6&db=m Expression and modulation of protein kinase C isoforms in differentiation-competent and differentiation-resistant erythroleukemic cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7925435&form=6&db=m Modulation of the intracellular Ca(2+)-dependent proteolytic system is critically correlated with the kinetics of differentiation of murine erythroleukemia cells. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980501&form=6&db=m Differential expression of protein kinase C isoform genes in three murine erythroleukemia cell variants: implication for chemical induced differentiation. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8181571&form=6&db=m Protein kinase C isoforms in murine erythroleukemia cells and their involvement in the differentiation process. ongoing research,unassigned 2,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8221697&form=6&db=m Differential modulation of protein kinase C isoforms in erythroleukemia during induced differentiation. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8340409&form=6&db=m Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation. causal interaction,unassigned 3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569755&form=6&db=m Protein kinase C beta from Friend erythroleukemia cells is associated with chromatin and DNA. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8602851&form=6&db=m Correlation between levels of delta protein kinase C and resistance to differentiation in murine erythroleukemia cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698746&form=6&db=m Dexniguldipine hydrochloride, a protein-kinase-C-specific inhibitor, affects the cell cycle, differentiation, P-glycoprotein levels, and nuclear protein phosphorylation in Friend erythroleukemia cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8900191&form=6&db=m Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation. ongoing research,unassigned 1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9284955&form=6&db=m dl-alpha-tocopherol, a potent inhibitor of phorbol ester induced shape change of erythro- and megakaryoblastic leukemia cells. ongoing research,unassigned 1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685375&form=6&db=m Mapping of a molecular determinant for protein kinase C betaII isozyme function. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9925750&form=6&db=m Protein kinase calpha is an effector of hexamethylene bisacetamide-induced differentiation of Friend erythroleukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10459861&form=6&db=m Co-ordinate expression of activin A and its type I receptor mRNAs during phorbol ester-induced differentiation of human K562 erythroleukemia cells. ongoing research,unassigned 2,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872805&form=6&db=m 4-Hydroxynonenal-induced MEL cell differentiation involves PKC activity translocation. causal interaction,unassigned 4,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11080619&form=6&db=m Phosphatidylinositol-3-kinase activation and atypical protein kinase C zeta phosphorylation characterize the DMSO signalling in erythroleukemia cells. unassigned - 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11521190&form=6&db=m NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11748589&form=6&db=m Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12461784&form=6&db=m Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells. unassigned - 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12469195&form=6&db=m Engagement of PI-3-kinase mediated protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis. therapeutic application,unassigned 1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758751&form=6&db=m Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19028838&form=6&db=m Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691493&form=6&db=m Dual mitochondrial localization and different roles of the reversible reaction of mammalian ferrochelatase. unassigned - 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1868447&form=6&db=m Expression of three major protein kinase C isozymes in various types of human leukemic cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2026453&form=6&db=m High-affinity interleukin 2 receptors on B cell chronic lymphocytic leukemia cells are induced by phorbol myristate acetate but not by calcium ionophore. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7769846&form=6&db=m Phosphorylation of the MARCKS family of protein kinase C substrates in human B chronic lymphocytic leukemia cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8374521&form=6&db=m Induction of differentiation of B-cell leukemia cell lines JVM-2 and EHEB by bryostatin 1. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9607595&form=6&db=m Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11929788&form=6&db=m Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15291360&form=6&db=m Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15929099&form=6&db=m Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. causal interaction,unassigned 4,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168795&form=6&db=m PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. causal interaction,unassigned 3,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19907441&form=6&db=m Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70. unassigned - 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23343179&form=6&db=m Protein kinase C expression is deregulated in chronic lymphocytic leukemia. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469961&form=6&db=m Protein Kinase C isoform expression in chronic lymphocytic leukemia: a potential target for therapy? causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24174318&form=6&db=m Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1742331&form=6&db=m Effect of TPA on fructose 2,6-bisphosphate levels and protein kinase C activity in B-chronic lymphocytic leukemia (B-CLL). causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8596017&form=6&db=m Characterization and purification of a protein kinase C substrate in human B cells. Identification as lymphocyte-specific protein 1 (LSP1). therapeutic application,unassigned 1,0 2.7.11.13 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836167&form=6&db=m Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12350143&form=6&db=m Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. ongoing research,unassigned 1,0 2.7.11.13 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27457194&form=6&db=m Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Megakaryoblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15567063&form=6&db=m Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO. ongoing research,unassigned 2,0 2.7.11.13 Leukemia, Monocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201988&form=6&db=m Pivotal Advance: PKC{zeta} is required for migration of macrophages. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2018793&form=6&db=m Altered erythrocyte protein kinase C activity and membrane protein phosphorylation in chronic myelogenous leukemia. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.13 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2386956&form=6&db=m Differentiation and growth modulation of chronic myelogenous leukemia cells by bryostatin. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2608443&form=6&db=m Protein kinase C deficiency in juvenile chronic myeloid leukemia: a case report. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11734305&form=6&db=m Protein kinase C isoforms in normal and leukemic neutrophils: altered levels in leukemic neutrophils and changes during myeloid maturation in chronic myeloid leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670960&form=6&db=m Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15850832&form=6&db=m Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1743296&form=6&db=m Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1939341&form=6&db=m Inhibition of phorbol ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun (AP-1). unassigned - 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2175219&form=6&db=m Control of interleukin-1 beta expression by protein kinase C and cyclic adenosine monophosphate in myeloid leukemia cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2465043&form=6&db=m Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2790038&form=6&db=m Differential responsiveness to phorbol esters correlates with differential expression of protein kinase C in KG-1 and KG-1a human myeloid leukemia cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824237&form=6&db=m Characterization of a relationship between the T-lymphocyte derived differentiation inducing factor (DIF) and lymphotoxin: a common receptor system for DIF, lymphotoxin and tumor necrosis factor downregulated by phorbol diesters. therapeutic application,unassigned 1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3156372&form=6&db=m Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3166453&form=6&db=m Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3479244&form=6&db=m Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7949469&form=6&db=m Modulation of 1-[beta-D-arabinofuranosyl] cytosine-induced apoptosis in human myeloid leukemia cells by staurosporine and other pharmacological inhibitors of protein kinase C. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7974383&form=6&db=m Different regulation of plasminogen activator inhibitor 2 gene expression by phorbol ester and cAMP in human myeloid leukemia cell line PL-21. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058058&form=6&db=m 1-beta-D-arabinofuranosylcytosine activates serine/threonine protein kinases and c-jun gene expression in phorbol ester-resistant myeloid leukemia cells. ongoing research,unassigned 2,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8288641&form=6&db=m Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8477194&form=6&db=m Differentiation and growth modulation of myeloid leukemia cells by the protein kinase C activating agent bryostatin-1. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8555011&form=6&db=m Long-wave ultraviolet radiation causes increase of membrane-bound fraction of protein kinase C in rat myeloid leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8622627&form=6&db=m Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8683995&form=6&db=m Effect of AS101 on bryostatin 1-mediated differentiation induction, cell cycle arrest, and modulation of drug-induced apoptosis in human myeloid leukemia cells. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8835291&form=6&db=m Regulation of cell cycle and apoptosis by protein kinase C in rat myeloid leukemia cell line. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8892972&form=6&db=m Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: relationship to differentiation and ara-C-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8972634&form=6&db=m The effects of the broadband UVA radiation on myeloid leukemia cells: the possible role of protein kinase C in mediation of UVA-induced effects. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395460&form=6&db=m Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9396780&form=6&db=m Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858570&form=6&db=m Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,3 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9933579&form=6&db=m Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis. therapeutic application,unassigned 2,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10516758&form=6&db=m Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10951587&form=6&db=m Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11042219&form=6&db=m Phorbol ester-induced generation of reactive oxygen species is protein kinase cbeta -dependent and required for SAPK activation. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11139146&form=6&db=m Protein kinase C activation modulates pro- and anti-apoptotic signaling pathways. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880362&form=6&db=m Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12522001&form=6&db=m Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells. unassigned - 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12533676&form=6&db=m Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684678&form=6&db=m Inactive caspase 3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol ester. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17508000&form=6&db=m Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544391&form=6&db=m Relation of protein kinase A and protein kinase C to signaling pathways of hematopoietic factors in leukemia cell lines. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25449427&form=6&db=m The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1593908&form=6&db=m Effect of a combined exposure to cytosine arabinoside, bryostatin 1, and recombinant granulocyte-macrophage colony-stimulating factor on the clonogenic growth in vitro of normal and leukemic human hematopoietic progenitor cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1868447&form=6&db=m Expression of three major protein kinase C isozymes in various types of human leukemic cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2027297&form=6&db=m Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia. causal interaction,unassigned 3,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3469014&form=6&db=m Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a. ongoing research,unassigned 4,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3479244&form=6&db=m Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8642857&form=6&db=m Expression of PKC isozyme and MDR-associated genes in primary and relapsed state AML. causal interaction,unassigned 1,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778970&form=6&db=m BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805378&form=6&db=m Activation of protein kinase C delta by all-trans-retinoic acid. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14725904&form=6&db=m Treosulfan-induced apoptosis in acute myeloid leukemia cells is accompanied by translocation of protein kinase C delta and enhanced by bryostatin-1. unassigned - 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845901&form=6&db=m PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17115221&form=6&db=m T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005. therapeutic application,unassigned 2,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19747914&form=6&db=m Protein Kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: Involvement in apoptosis induction. therapeutic application,unassigned 2,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887445&form=6&db=m Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360576&form=6&db=m Targeting PKC mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid Leukemia-Derived cell lines and blast cells. diagnostic usage,unassigned 1,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592076&form=6&db=m Synergistic effect of all?trans retinoic acid in combination with protein kinase C 412 in FMS-like tyrosine kinase 3-mutated acute myeloid leukemia cells. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29127121&form=6&db=m Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia. causal interaction,unassigned 3,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30017192&form=6&db=m Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32203165&form=6&db=m Tetraspanin CD82 drives acute myeloid leukemia chemoresistance by modulating protein kinase C alpha and ?1 integrin activation. unassigned - 2.7.11.13 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32428837&form=6&db=m The Novel Phospholipid Mimetic KPC34 Is Highly Active Against Acute Myeloid Leukemia with Activated Protein Kinase C. therapeutic application,unassigned 3,0 2.7.11.13 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425005&form=6&db=m [A laboratory and clinical study of induced differentiation therapy by all trans-retinoic acid in acute promyelocytic leukemia] causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1879193&form=6&db=m Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.11.13 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805378&form=6&db=m Activation of protein kinase C delta by all-trans-retinoic acid. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540999&form=6&db=m Dual effects of protein kinase-C on receptor-stimulated cAMP accumulation in a human T-cell leukemia line. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038616&form=6&db=m Activation of protein kinase C inhibits prostaglandin- and potentiates adenosine receptor-stimulated accumulation of cyclic AMP in a human T-cell leukemia line. ongoing research,unassigned 3,0 2.7.11.13 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11222091&form=6&db=m Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274147&form=6&db=m Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592506&form=6&db=m PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17846228&form=6&db=m The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKCtheta and ERK pathways. ongoing research,unassigned 2,0 2.7.11.13 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462800&form=6&db=m Impaired anti-leukemic immune response in PKCtheta-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1421175&form=6&db=m Altered expression of protein kinase C in adult T-cell leukemia cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Leukodystrophy, Globoid Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3101176&form=6&db=m Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606527&form=6&db=m Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17941874&form=6&db=m Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy. causal interaction,unassigned 1,0 2.7.11.13 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27128219&form=6&db=m Angiogenesis and Inflammation Crosstalk in Diabetic Retinopathy. unassigned - 2.7.11.13 Lipid Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29927433&form=6&db=m [The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors]. unassigned - 2.7.11.13 Lissencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384287&form=6&db=m Characterization of a Drosophila melanogaster orthologue of muskelin. unassigned - 2.7.11.13 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11206314&form=6&db=m Subcellular redistribution of protein kinase C isozymes is associated with rat liver cirrhotic changes induced by carbon tetrachloride or thioacetamide. causal interaction,unassigned 4,0 2.7.11.13 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957207&form=6&db=m Angiotensin-II induces the tissue inhibitor of metalloproteinases-1 through the protein kinase-C signaling pathway in rat liver fibrosis development. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29326488&form=6&db=m Resveratrol prevents liver fibrosis via two possible pathways: Modulation of alpha fetoprotein transcriptional levels and normalization of protein kinase C responses. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31533364&form=6&db=m PKC? Mediates NF-?B Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626764&form=6&db=m Regulation of organic anion transport in the liver. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057895&form=6&db=m Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease. causal interaction,unassigned 4,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15188177&form=6&db=m Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15382167&form=6&db=m Polycystic disease of the liver. unassigned - 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16437702&form=6&db=m Autosomal dominant polycystic liver disease in a family without polycystic kidney disease associated with a novel missense protein kinase C substrate 80K-H mutation. causal interaction,unassigned 1,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022218&form=6&db=m PKCepsilon plays a causal role in acute ethanol-induced steatosis. therapeutic application,unassigned 1,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24454937&form=6&db=m Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis. ongoing research,unassigned 2,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24506938&form=6&db=m Polycystic liver disease: ductal plate malformation and the primary cilium. causal interaction,unassigned 1,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26671672&form=6&db=m Hepatocystin is Essential for TRPM7 Function During Early Embryogenesis. causal interaction,unassigned 3,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29046367&form=6&db=m PKC? silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity. unassigned - 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30172093&form=6&db=m An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31220350&form=6&db=m Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ?. causal interaction,unassigned 1,0 2.7.11.13 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795668&form=6&db=m Alteration of protein kinase C isoforms in the liver of septic rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.7.11.13 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12785016&form=6&db=m Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line. causal interaction,unassigned 1,0 2.7.11.13 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205321&form=6&db=m Role of cAMP-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase C alpha suppression during sepsis. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26730154&form=6&db=m Sphingosine kinase 1 dependent protein kinase C-? activation plays an important role in acute liver failure in mice. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8697446&form=6&db=m The altered activity of membrane-bound protein kinase C in human liver cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059864&form=6&db=m In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-alpha. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090966&form=6&db=m Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498560&form=6&db=m The C-terminal 26-residue peptide of serpin A1 stimulates proliferation of breast and liver cancer cells: role of protein kinase C and CD47. ongoing research,unassigned 1,0 2.7.11.13 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31543517&form=6&db=m Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC. diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2623023&form=6&db=m Phorbol esters and forskolin infused into midbrain central gray facilitate lordosis. therapeutic application,unassigned 3,0 2.7.11.13 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7820693&form=6&db=m Activation of protein kinase C in the hypothalamic ventromedial nucleus or the midbrain central gray facilitates lordosis. diagnostic usage,unassigned 1,0 2.7.11.13 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9638959&form=6&db=m Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.11.13 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17680887&form=6&db=m In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18675324&form=6&db=m Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743347&form=6&db=m Lordosis facilitation by leptin in ovariectomized, estrogen-primed rats requires simultaneous or sequential activation of several protein kinase pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15572532&form=6&db=m Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17200189&form=6&db=m Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18342628&form=6&db=m PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536527&form=6&db=m The effect of acute inflammatory lung injury on the respiratory burst and protein kinase C activity of rat pulmonary alveolar macrophages. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8143048&form=6&db=m Increase in filtration coefficient from actions of melittin on neutrophils in isolated rabbit lungs. causal interaction,unassigned 4,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987392&form=6&db=m Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18354190&form=6&db=m Protein Kinase C{alpha} and {zeta} Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23221045&form=6&db=m Protein Kinase C-? Mediates Lung Injury Induced by Diesel Exhaust Particles. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211111&form=6&db=m Pulmonary endothelial protein kinase C-delta (PKC?) regulates neutrophil migration in acute lung inflammation. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25862813&form=6&db=m Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28203478&form=6&db=m Potential Biochemical Mechanisms of Lung Injury in Diabetes. causal interaction,unassigned 2,0 2.7.11.13 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33584346&form=6&db=m Co-inhibition of CD73 and ADORA2B Improves Long-Term Cigarette Smoke Induced Lung Injury. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329908&form=6&db=m Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655253&form=6&db=m c-myc gene-induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation. ongoing research,unassigned 4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498255&form=6&db=m Lung cancer cells often express high levels of protein kinase C activity. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3142461&form=6&db=m A23187 and protein kinase C activators stimulate phosphatidylinositol metabolism and prostaglandin synthesis in a human lung cancer cell line. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7763022&form=6&db=m Associated expression of protein kinase C with resistance to doxorubicin in human lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7925852&form=6&db=m Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. ongoing research,unassigned 4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8262160&form=6&db=m Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells. unassigned - 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8312363&form=6&db=m Expression and secretion of parathyroid hormone-related protein by a human cancer cell line. ongoing research,unassigned 4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8720314&form=6&db=m Effects of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8822090&form=6&db=m Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9205066&form=6&db=m Cholera toxin triggers apoptosis in human lung cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,2 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600337&form=6&db=m Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9973202&form=6&db=m Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375741&form=6&db=m Antisense expression of protein kinase C alpha improved sensitivity to anticancer drugs in human lung cancer LTEPa-2 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509123&form=6&db=m Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821018&form=6&db=m Molecular and pharmacological properties of inwardly rectifying K+ channels of human lung cancer cells. unassigned - 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121973&form=6&db=m Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470903&form=6&db=m Involvement of TNF-alpha changes in human cancer development, prevention and palliative care. ongoing research,unassigned 2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591726&form=6&db=m Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14662029&form=6&db=m LY900003 (Affinitac), an antisense inhibitor of protein kinase C-alpha, in non-small-cell lung cancer. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14709334&form=6&db=m Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760128&form=6&db=m Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075332&form=6&db=m Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor. therapeutic application,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210690&form=6&db=m Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. causal interaction,unassigned 1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15447994&form=6&db=m A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555220&form=6&db=m Expression levels of protein kinase C-alpha in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15696546&form=6&db=m Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705582&form=6&db=m Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. causal interaction,unassigned 1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15994303&form=6&db=m Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16087181&form=6&db=m The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204062&form=6&db=m Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16211258&form=6&db=m Role of protein kinase C in expression of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361262&form=6&db=m Protein Kinase C{iota} Promotes Nicotine-induced Migration and Invasion of Cancer Cells via Phosphorylation of {micro}- and m-Calpains. causal interaction,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507327&form=6&db=m Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16549837&form=6&db=m Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16801349&form=6&db=m Protein kinase Cgamma autoimmunity in paraneoplastic cerebellar degeneration and non-small-cell lung cancer. diagnostic usage,unassigned 2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16810323&form=6&db=m FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. ongoing research,unassigned 2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16861740&form=6&db=m Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982626&form=6&db=m Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044994&form=6&db=m [nm23-H1 gene inhibits lung cancer cell invasion through down-regulation of PKC signal pathway] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17168668&form=6&db=m High-throughput functional genomic methods to analyze the effects of dietary lipids. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17273774&form=6&db=m Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525161&form=6&db=m Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation. causal interaction,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17570678&form=6&db=m Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616661&form=6&db=m Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18158564&form=6&db=m Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18162471&form=6&db=m S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. unassigned - 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18401527&form=6&db=m Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18590793&form=6&db=m Activation of protein kinase Calpha signaling prevents cytotoxicity and mutagenicity following lead acetate in CL3 human lung cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632643&form=6&db=m Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701187&form=6&db=m Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19333010&form=6&db=m Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19413889&form=6&db=m MINERVAL INDUCES APOPTOSIS IN JURKAT AND OTHER CANCER CELLS. unassigned - 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567915&form=6&db=m PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19738040&form=6&db=m Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19906497&form=6&db=m Enzastaurin (LY317615), a Protein Kinase C Beta Selective Inhibitor, Enhances Antiangiogenic Effect of Radiation. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20436341&form=6&db=m Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20646461&form=6&db=m [Effects of a protein kinase C inhibitor combined with cisplatin on non-small cell lung cancer] diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673527&form=6&db=m [The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712961&form=6&db=m [Protein kinase C inhibitor and treatment of non-small cell lung cancer.] therapeutic application,unassigned 4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731935&form=6&db=m [The variation of intracellular distribution and translocation of the protein kinase C alpha among human lung cancer cell line with different metastasis potential.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21211186&form=6&db=m [A study on the relationship between the expression of protein kinase C ?II and apoptosis in patients with non-small cell lung cancer.] diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21214997&form=6&db=m [Study on protein kinase C translocation before and after transfection of nm23-H1 gene in human lung cancer cells using Laser scanning confocal microscope.] ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219643&form=6&db=m Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22384062&form=6&db=m Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993309&form=6&db=m Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells. therapeutic application,unassigned 1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23249950&form=6&db=m Atypical protein kinase C phosphorylates Par6 and facilitates transforming growth factor ?-induced epithelial-to-mesenchymal transition. causal interaction,unassigned 1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23962904&form=6&db=m Phase I dose escalation study of the PKC? inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer. causal interaction,unassigned 4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24250666&form=6&db=m Preparation and in-vitro Evaluation of an Antisense-containing Cationic Liposome against Non-small Cell Lung Cancer: a Comparative Preparation Study. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24461294&form=6&db=m Inhibition of protein kinase C ?/?II and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636699&form=6&db=m The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25351171&form=6&db=m The protein kinase C (PKC) inhibitors combined with chemotherapy in the treatment of advanced non-small cell lung cancer: meta-analysis of randomized controlled trials. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25724832&form=6&db=m Protein Kinase C Alpha Mediates Erlotinib Resistance in Lung Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484266&form=6&db=m Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498639&form=6&db=m Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC??/ERK1/2 pathway: An in vitro investigation. causal interaction,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26918447&form=6&db=m PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554601&form=6&db=m 14-3-3? promotes lung cancer cell invasion by increasing the Snail protein expression through atypical protein kinase C (aPKC)/NF-?B signaling. causal interaction,unassigned 4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28092804&form=6&db=m Enhancement of NK cell-mediated lysis of non-small lung cancer cells by nPKC activator, ingenol 3,20 dibenzoate. ongoing research,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28368426&form=6&db=m Co-dependency of PKC? and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28399187&form=6&db=m Additive effects of cherlerythrine chloride combination with erlotinib in human non-small cell lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28590507&form=6&db=m Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29528086&form=6&db=m Epac1 is involved in cell cycle progression in lung cancer through PKC and Cx43 regulation. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30770789&form=6&db=m PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988374&form=6&db=m Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes. unassigned - 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648127&form=6&db=m Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer. therapeutic application,unassigned 3,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648598&form=6&db=m PKC? regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells. unassigned - 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32015677&form=6&db=m Ophiopogon Saponin C1 Inhibits Lung Tumors by Stabilizing Endothelium Permeability via Inhibition of PKC?. causal interaction,unassigned 1,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158232&form=6&db=m Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-?/FAK Ubiquitination Through the Cbl-b Pathway. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32994205&form=6&db=m PKC epsilon is required for KRAS-driven lung tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324562&form=6&db=m Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients. causal interaction,diagnostic usage,unassigned 2,2,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073823&form=6&db=m Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195807&form=6&db=m Prostasin regulates PD-L1 expression in human lung cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34472101&form=6&db=m l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. unassigned - 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2070568&form=6&db=m A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus. ongoing research,unassigned 4,0 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15379867&form=6&db=m Abnormal cell-specific expressions of certain protein kinase C isoenzymes in peripheral mononuclear cells of patients with systemic lupus erythematosus: effect of corticosteroid application. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21516291&form=6&db=m Adenosine inhibits the release of arachidonic acid in activated human peripheral mononuclear cells. A proposed model for physiologic and pathologic regulation in systemic lupus erythematosus. unassigned - 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21988336&form=6&db=m Different effects of Bortezomib on the expressions of various PKC isoenzymes in T cells of patients with systemic lupus erythematosus and in Jurkat cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23612780&form=6&db=m The in vitro treatment with vitamin D3 is ineffective on the expression of PKC isoenzymes, but decreases further the impaired production of IL-2 in the T lymphocytes of SLE patients. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27541826&form=6&db=m Protein Kinase C ?: a Gatekeeper of Immune Homeostasis. causal interaction,unassigned 1,0 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257684&form=6&db=m Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C ?. unassigned - 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30715676&form=6&db=m Season Dependent Changes in the Expression of Protein Kinase C Isoenzymes in a Female Patient with Systemic Lupus Erythematosus. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34264265&form=6&db=m Impaired respiratory burst contributes to infections in PKC?-deficient patients. causal interaction,unassigned 3,0 2.7.11.13 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17394560&form=6&db=m Role of novel protein kinase C isoforms in Lyme arthritis. unassigned - 2.7.11.13 Lymphadenitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15453855&form=6&db=m The protein kinase C system in focal adenitis of the lacrimal gland in the non-obese diabetic mouse model for Sjögren's syndrome. therapeutic application,unassigned 1,0 2.7.11.13 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161701&form=6&db=m Pak-1 expression increases with progression of colorectal carcinomas to metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20384629&form=6&db=m Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895402&form=6&db=m Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22868505&form=6&db=m Localization of PKC? in Cell Membranes as a Predictor for Breast Cancer Response to Treatment. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2732469&form=6&db=m Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=191831&form=6&db=m Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=193571&form=6&db=m Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line. ongoing research,unassigned 4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559218&form=6&db=m In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium. therapeutic application,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1623554&form=6&db=m Transient down-regulation of PKC-zeta RNA following crosslinking of membrane IgM on WEHI-231 B lymphoma cells. ongoing research,unassigned 2,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1858866&form=6&db=m Differential effects of omega-3 fish oils on protein kinase activities in vitro. ongoing research,unassigned 4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1918971&form=6&db=m Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation. ongoing research,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163616&form=6&db=m Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2328538&form=6&db=m Lymphoma models for B cell activation and tolerance. VIII. Cross-desensitization by sIgM and sIgD and its effects on growth regulation by anti-isotype antibodies. causal interaction,unassigned 4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2470741&form=6&db=m Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492471&form=6&db=m Downregulation of T cell growth factor production by ornithine decarboxylase and its product putrescine: D,L-alpha-difluoromethylornithine suppresses general protein synthesis but augments simultaneously the production of interleukin-2. therapeutic application,unassigned 1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2668012&form=6&db=m Membrane IgM cross-linking is not coupled to protein kinase C translocation in WEHI-231 B lymphoma cells. unassigned - 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2798438&form=6&db=m Effects of mezerein and diglycerides on the PRL stimulation of cell replication in Nb2 node lymphoma cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2813443&form=6&db=m Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836499&form=6&db=m Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells. unassigned - 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3035937&form=6&db=m Multiple effects of phorbol esters on hormone-sensitive adenylate cyclase activity in S49 lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038996&form=6&db=m Protein kinase C activation blocks anti-IgM-mediated signaling BAL17 B lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093404&form=6&db=m Prolactin stimulation of ornithine decarboxylase and mitogenesis in Nb2 node lymphoma cells: the role of protein kinase C and calcium mobilization. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3161729&form=6&db=m Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. therapeutic application,unassigned 1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3263124&form=6&db=m Increased degradation of protein kinase C without diminution of mRNA level after treatment of WEHI-231 B lymphoma cells with phorbol esters. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3957464&form=6&db=m Modulation of protein kinase C and Ca2+ lipid-independent protein kinase in lymphoma induced by Moloney murine leukemia virus in BALB/c mice. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7490210&form=6&db=m Cochlioquinone A, an inhibitor of diacylglycerol kinase. unassigned - 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7643856&form=6&db=m Invariant chain (CD74) gene regulation: enhanced expression associated with activation of protein kinase C delta in a murine B lymphoma cell line. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706371&form=6&db=m Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells. ongoing research,unassigned 2,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7843222&form=6&db=m Regulation of non-classical protein kinase C isoenzymes in a human T cell line. ongoing research,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224186&form=6&db=m Conventional protein kinase C isoforms are not essential for cellular proliferation of a T cell lymphoma line. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8299681&form=6&db=m The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8436813&form=6&db=m Regulation of protein kinase C isoform proteins in phorbol ester-stimulated Jurkat T lymphoma cells. unassigned - 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8436973&form=6&db=m Prolactin-stimulated mitogenesis of cultured astrocytes is mediated by a protein kinase C-dependent mechanism. causal interaction,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663197&form=6&db=m Protein kinase C-delta mRNA is down-regulated transcriptionally and post-transcriptionally by 12-O-tetradecanoylphorbol-13-acetate. therapeutic application,unassigned 1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9452362&form=6&db=m Stabilization of invariant chain mRNA by 12-O-tetradecanoylphorbol-13-acetate is blocked by IFN-gamma in a murine B lymphoma cell line. ongoing research,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9926251&form=6&db=m Molecular basis of targeted chemotherapy: novel concepts with special reference to the treatment of Hodgkin's disease. therapeutic application,unassigned 4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10846563&form=6&db=m Expression of classical protein kinase C subspecies in non-neoplastic lymphocytes and non-Hodgkin's lymphomas: an immunohistochemical study. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12385783&form=6&db=m Differential expression of protein kinase C isoenzymes related to high nitric oxide synthase activity in a T lymphoma cell line. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14677764&form=6&db=m Modulation of CD40L antigen expression in Jurkat cells: involvement of protein kinase C activity. unassigned - 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14737004&form=6&db=m Sodium selenite-induced apoptosis in murine B-lymphoma cells is associated with inhibition of protein kinase C-delta, nuclear factor kappaB, and inhibitor of apoptosis protein. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15028022&form=6&db=m Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592506&form=6&db=m PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564096&form=6&db=m Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking. therapeutic application,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17394491&form=6&db=m Heterogeneity of protein kinase C beta(2) expression in lymphoid malignancies. causal interaction,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855629&form=6&db=m PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906297&form=6&db=m A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20218811&form=6&db=m Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544367&form=6&db=m In vivo and in vitro modulatory effect of human immunodeficiency virus type-1 (HIV-1) Tat protein on protein kinase C activity. ongoing research,unassigned 4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22132835&form=6&db=m Antioxidant ?-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-? and c-Myc genes and glycolytic metabolism. therapeutic application,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23889282&form=6&db=m The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways. causal interaction,unassigned 1,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24880241&form=6&db=m Bcl-2/Bax Expression Levels Tend to Influence AMPAergic Trafficking Mechanisms During Hibernation in Mesocricetus auratus. unassigned - 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26914495&form=6&db=m Targeting protein kinase C in mantle cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26921474&form=6&db=m A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells. causal interaction,unassigned 3,0 2.7.11.13 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034696&form=6&db=m Turn up the cellular power generator with vitamin E analogue formulation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945801&form=6&db=m Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9548940&form=6&db=m Cross-talk between protein kinase C-alpha (PKC-alpha) and -delta (PKC-delta): PKC-alpha elevates the PKC-delta protein level, altering its mRNA transcription and degradation. causal interaction,unassigned 1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15028022&form=6&db=m Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389337&form=6&db=m Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19234720&form=6&db=m Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536846&form=6&db=m Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant. therapeutic application,unassigned 3,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20190733&form=6&db=m Prognostic impact of protein kinase C beta II expression in R-CHOP-treated diffuse large B-cell lymphoma patients. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20218811&form=6&db=m Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20453535&form=6&db=m Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects. unassigned - 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324920&form=6&db=m Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas. therapeutic application,unassigned 1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24030399&form=6&db=m Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus. ongoing research,unassigned 1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24880241&form=6&db=m Bcl-2/Bax Expression Levels Tend to Influence AMPAergic Trafficking Mechanisms During Hibernation in Mesocricetus auratus. unassigned - 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27217449&form=6&db=m Randomized, Double-Blind, Phase III Trial of Enzastaurin Versus Placebo in Patients Achieving Remission After First-Line Therapy for High-Risk Diffuse Large B-Cell Lymphoma. therapeutic application,unassigned 4,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28246354&form=6&db=m Protein kinase C ? inhibits autophagy and sensitizes cervical cancer Hela cells to cisplatin. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28409550&form=6&db=m ERK and p38 upregulation versus Bcl-6 downregulation in rat kidney epithelial cells exposed to prolonged hypoxia. causal interaction,unassigned 1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034696&form=6&db=m Turn up the cellular power generator with vitamin E analogue formulation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524008&form=6&db=m Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131018&form=6&db=m Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion. causal interaction,unassigned 3,0 2.7.11.13 Lymphoma, B-Cell, Marginal Zone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691723&form=6&db=m Immunohistochemical staining of protein kinase C isozymes (betaII and delta) is helpful to distinguish reactive follicles from follicular colonization of MALT lymphoma. unassigned - 2.7.11.13 Lymphoma, Follicular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855629&form=6&db=m PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3295440&form=6&db=m Phorbol esters, but not the hormonal form of vitamin D, induce changes in protein kinase C during differentiation of human histiocytic lymphoma cell line (U-937). ongoing research,unassigned 1,0 2.7.11.13 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15028022&form=6&db=m Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: Relationship between its expression and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389337&form=6&db=m Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536846&form=6&db=m Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant. therapeutic application,unassigned 3,0 2.7.11.13 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20190733&form=6&db=m Prognostic impact of protein kinase C beta II expression in R-CHOP-treated diffuse large B-cell lymphoma patients. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27217449&form=6&db=m Randomized, Double-Blind, Phase III Trial of Enzastaurin Versus Placebo in Patients Achieving Remission After First-Line Therapy for High-Risk Diffuse Large B-Cell Lymphoma. therapeutic application,unassigned 4,0 2.7.11.13 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906297&form=6&db=m A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.11.13 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26914495&form=6&db=m Targeting protein kinase C in mantle cell lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3179314&form=6&db=m Synthetic peptides derived from the nonmuscle myosin light chains are highly specific substrates for protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319248&form=6&db=m Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944291&form=6&db=m Enhanced expression of CD20 in human tumor B cells is controlled through ERK-dependent mechanisms. ongoing research,unassigned 1,0 2.7.11.13 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1577171&form=6&db=m Development and characterization of a protein kinase C beta-isozyme-deficient T-cell line. ongoing research,unassigned 3,0 2.7.11.13 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7490210&form=6&db=m Cochlioquinone A, an inhibitor of diacylglycerol kinase. unassigned - 2.7.11.13 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7843222&form=6&db=m Regulation of non-classical protein kinase C isoenzymes in a human T cell line. ongoing research,unassigned 3,0 2.7.11.13 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224186&form=6&db=m Conventional protein kinase C isoforms are not essential for cellular proliferation of a T cell lymphoma line. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8307616&form=6&db=m Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line. ongoing research,unassigned 3,0 2.7.11.13 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592506&form=6&db=m PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Lymphoma, T-Cell, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547380&form=6&db=m Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Lymphoma, T-Cell, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16645590&form=6&db=m The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Lymphoma, T-Cell, Peripheral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309400&form=6&db=m Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-kappaB in peripheral T-cell lymphomas and is associated with clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Lymphoproliferative Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111648&form=6&db=m A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C. therapeutic application,unassigned 4,0 2.7.11.13 Lymphoproliferative Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18486150&form=6&db=m Cyclosporin A Up-Regulates and Activates Protein Kinase C-zeta in EBV-Infected and EBV-Transformed Human B-Cells. causal interaction,unassigned 4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507629&form=6&db=m Mechanisms for monitoring changes in retinal status following therapeutic intervention in diabetic retinopathy. therapeutic application,unassigned 4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12687341&form=6&db=m Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789620&form=6&db=m Ruboxistaurin (Eli Lilly). causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523197&form=6&db=m Pharmacotherapy for diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186374&form=6&db=m Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408491&form=6&db=m Update on treatments for diabetic macular edema. therapeutic application,unassigned 1,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19951615&form=6&db=m Update on treatments of diabetic macular edema. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110406&form=6&db=m Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939796&form=6&db=m Protein Kinase C Inhibitors in the Treatment of Diabetic Retinopathy. Review. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26015772&form=6&db=m IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Magnesium Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704642&form=6&db=m Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668256&form=6&db=m Activation of nuclear transcription factor-kappa B is associated with the induction of inhibitory kappa B kinase-beta and involves differential activation of protein kinase C and protein tyrosine kinases during fatal murine cerebral malaria. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660606&form=6&db=m Protein kinase C ? deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria. causal interaction,unassigned 4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8513036&form=6&db=m Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493480&form=6&db=m Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients. causal interaction,unassigned 3,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632242&form=6&db=m A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania. therapeutic application,unassigned 4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845270&form=6&db=m Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18316672&form=6&db=m Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18652785&form=6&db=m Protein kinase C inhibition: a target for treatment of mania. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18789340&form=6&db=m Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of Mania. therapeutic application,unassigned 4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18980735&form=6&db=m A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19552485&form=6&db=m Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22272765&form=6&db=m Protein kinase C and oxidative stress in an animal model of mania. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23076832&form=6&db=m Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23228462&form=6&db=m Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25577667&form=6&db=m Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania. unassigned - 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27088436&form=6&db=m Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials. diagnostic usage,therapeutic application,unassigned 2,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27585851&form=6&db=m Tamoxifen and amphetamine abuse: Are there therapeutic possibilities? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28104366&form=6&db=m Effects of acute and chronic quercetin administration on methylphenidate-induced hyperlocomotion and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29020306&form=6&db=m Lithium and Tamoxifen Modulate Behavior and Protein Kinase C Activity in the Animal Model of Mania Induced by Ouabain. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29197846&form=6&db=m Severe recurrent hypothermia in an elderly patient with refractory mania associated with atypical antipsychotic, valproic acid and oxcarbazepine therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32243997&form=6&db=m Protein kinase C isoforms as a target for manic-like behaviors and oxidative stress in a dopaminergic animal model of mania. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33104849&form=6&db=m Effects of tamoxifen and glutamate and glutamine levels in brain regions in repeated sleep deprivation-induced mania model in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33368969&form=6&db=m Endoxifen: A new, protein kinase C inhibitor to treat acute and mixed mania associated with bipolar I disorder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.7.11.13 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34214241&form=6&db=m Efficacy of endoxifen, a protein kinase C inhibitor for acute and mixed mania: Some concerns worth considering. therapeutic application,unassigned 4,0 2.7.11.13 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310050&form=6&db=m Synergistic effects of 12-O-tetradecanoylphorbol-13-acetate and dexamethasone on de novo synthesis of histidine decarboxylase in mouse mastocytoma P-815 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1543755&form=6&db=m Involvement of protein kinase C in thrombin-induced translocation of Gi2 alpha from the membrane to the cytosol in mouse mastocytoma P-815 cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2478192&form=6&db=m Cyclic AMP calcium and the growth of mastocytoma cells. ongoing research,unassigned 3,0 2.7.11.13 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183638&form=6&db=m Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE. ongoing research,unassigned 1,0 2.7.11.13 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1942251&form=6&db=m Early signal transduction in measles virus-infected lymphocytes is unaltered, but second messengers activate virus replication. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502430&form=6&db=m Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7645378&form=6&db=m Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection. diagnostic usage,unassigned 3,0 2.7.11.13 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9158096&form=6&db=m Measles virus induces apoptotic cell death in lymphocytes activated with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9185603&form=6&db=m Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319452&form=6&db=m Alpha-melanocyte-stimulating hormone stimulates protein kinase C activity in murine B16 melanoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1550338&form=6&db=m Regulation of protein kinase C gene expression by retinoic acid in B16 mouse melanoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559218&form=6&db=m In vivo administration of bryostatin 1, a protein kinase C activator, decreases murine resistance to Salmonella typhimurium. therapeutic application,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1618838&form=6&db=m Increased expression of protein kinase C alpha plays a key role in retinoic acid-induced melanoma differentiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1737379&form=6&db=m Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1988168&form=6&db=m The differential expression of protein kinase C genes in normal human neonatal melanocytes and metastatic melanomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2392322&form=6&db=m Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2461309&form=6&db=m Regulatory factors that determine growth and phenotype of normal human melanocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540997&form=6&db=m Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells. ongoing research,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2743337&form=6&db=m Induction of protein kinase C in mouse melanoma cells by retinoic acid. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2829178&form=6&db=m Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3166938&form=6&db=m Modulation by palmitoyl-carnitine of calcium activated, phospholipid-dependent protein kinase activity and inhibition of melanoma cell growth. ongoing research,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422445&form=6&db=m Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489747&form=6&db=m CD28:B7 interactions promote T cell adhesion. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7493637&form=6&db=m Retinoic acid specifically increases nuclear PKC alpha and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells. unassigned - 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7531203&form=6&db=m Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7568126&form=6&db=m 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. ongoing research,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678596&form=6&db=m Protein kinase C beta expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7685020&form=6&db=m The beta isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells. ongoing research,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7763017&form=6&db=m Dehydroepiandrosterone inhibits B16 mouse melanoma cell growth by induction of differentiation. ongoing research,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945369&form=6&db=m Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7950357&form=6&db=m Cellular pathways leading to melanoma differentiation: therapeutic implications. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8067288&form=6&db=m Interactions between retinoic acid and protein kinase C in induction of melanoma differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8157365&form=6&db=m Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes. ongoing research,unassigned 2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8226926&form=6&db=m Growth of melanocytic cells is associated with down-regulation of protein kinase C alpha, delta, and epsilon isoforms. Possible role of diacylglycerol. causal interaction,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253518&form=6&db=m Regulation of melanoma-cell motility by the lipoxygenase metabolite 12-(S)-HETE. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8314307&form=6&db=m Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8433008&form=6&db=m Selective increase of the alpha subspecies of protein kinase C and inhibition of melanogenesis induced by retinoic acid in melanoma cells. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8473569&form=6&db=m Cell shape changes induced by sulphate in the Cloudman mouse melanoma cell line. unassigned - 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8609374&form=6&db=m Association of protein kinase-C-alpha with cytoplasmic vesicles in melanoma cells. diagnostic usage,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8635492&form=6&db=m The relationship between susceptibility to retinoic acid treatment and protein kinase C alpha expression in murine melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8655594&form=6&db=m Deletion of specific protein kinase C subspecies in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8816909&form=6&db=m Regulation of melanogenesis in B16 mouse melanoma cells by protein kinase C. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8903945&form=6&db=m A selective protein kinase C inhibitor (CGP 41251) positively and negatively modulates melanoma cell MSH receptors. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9139741&form=6&db=m Characterization of retinoic acid-induced AP-1 activity in B16 mouse melanoma cells. causal interaction,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9192835&form=6&db=m The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. ongoing research,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344041&form=6&db=m Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9387248&form=6&db=m [Inhibition of experimental metastasis and cell adhesion of B16 murine melanoma cells by protein kinase C inhibitor CJ9111] ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9417870&form=6&db=m Characterization of density-dependent regulation of the tyrosinase gene promoter: role of protein kinase C. therapeutic application,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9578414&form=6&db=m Cell differentiation and cell-cycle alterations by tyrosine kinase inhibitors in human melanoma cells. ongoing research,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9652794&form=6&db=m Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9664144&form=6&db=m Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. therapeutic application,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679984&form=6&db=m Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1. causal interaction,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10583112&form=6&db=m Effects of protein kinase inhibitors on radiation-induced WAF1 accumulation in human cultured melanoma cells. ongoing research,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803709&form=6&db=m Overexpression of novel protein kinase C delta in BL6 murine melanoma cells inhibits the proliferative capacity in vitro but enhances the metastatic potential in vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10927861&form=6&db=m Investigation of signal transduction pathways involved in melanoma cell spreading. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10942517&form=6&db=m AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10999942&form=6&db=m Photo-induced inactivation of protein kinase calpha by dequalinium inhibits motility of murine melanoma cells. ongoing research,unassigned 2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11058161&form=6&db=m RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095401&form=6&db=m Survival mechanisms induced by 12-O-tetradecanoylphorbol-13-acetate in normal human melanocytes include inhibition of apoptosis and increased Bcl-2 expression. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11198473&form=6&db=m Overexpression of nPKCdelta in BL6 murine melanoma cells enhances TGFbeta1 release into the plasma of metastasized animals. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313150&form=6&db=m Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11479424&form=6&db=m Loss of expression of protein kinase C beta is a common phenomenon in human malignant melanoma: a result of transformation or differentiation? causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11546757&form=6&db=m Protein kinase Calpha plays a critical role in mannosylerythritol lipid-induced differentiation of melanoma B16 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11682463&form=6&db=m Atypical protein kinase Czeta suppresses migration of mouse melanoma cells. causal interaction,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704829&form=6&db=m Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11727793&form=6&db=m Stimulation of C32 and G361 melanoma cells using oleoyl acetyl glycerol and its effect on sulphur mustard cytotoxicity. unassigned - 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782382&form=6&db=m Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells. unassigned - 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850799&form=6&db=m The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. therapeutic application,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11894137&form=6&db=m Lack of protein kinase C (PKC)-beta and low PKC-alpha, -delta, -epsilon, and -zeta isozyme levels in proliferating human melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12000751&form=6&db=m Regulation of retinoic acid receptor alpha by protein kinase C in B16 mouse melanoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12074591&form=6&db=m Dual regulation of phospholipase D1 by protein kinase C alpha in vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12140376&form=6&db=m Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12170178&form=6&db=m Higher levels of melanin and inhibition of cdk2 activity in primary human melanoma cells WM115 overexpressing nPKCdelta. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12395925&form=6&db=m mda-7 (IL-24): signaling and functional roles. causal interaction,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12820400&form=6&db=m Effect of PKC412, an inhibitor of protein kinase C, on spontaneous metastatic model mice. ongoing research,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839565&form=6&db=m Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14517423&form=6&db=m Inhibition of PKCalpha decreases the gelatinase activity and the angiogenic and metastatic ability of the highly metastatic B16 murine melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14596936&form=6&db=m PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity. ongoing research,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646617&form=6&db=m Expression and regulation of phospholipase D isoenzymes in human melanoma cells and primary melanocytes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057036&form=6&db=m The role of protein kinase C-alpha (PKC-alpha) in melanoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15095285&form=6&db=m Proliferation of human melanoma cells is under tight control of protein kinase C alpha. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15538571&form=6&db=m Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15721302&form=6&db=m Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15827341&form=6&db=m Variable expression of protein kinase C epsilon in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907783&form=6&db=m Nuclear sphingomyelin-synthase and protein kinase C delta in melanoma cells. ongoing research,unassigned 2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15986138&form=6&db=m Protein kinase C in melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16305822&form=6&db=m Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon. ongoing research,unassigned 2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16499090&form=6&db=m [Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine] ongoing research,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17028922&form=6&db=m Expression of a metastatic phenotype in IFNs-primed/TNFalpha-activated B16 murine melanoma cells: role of JAK1/PKCdelta signal transduction factors. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047072&form=6&db=m Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160014&form=6&db=m Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17348006&form=6&db=m Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17625596&form=6&db=m Protein kinase C-betaII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17636410&form=6&db=m The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2. causal interaction,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17951407&form=6&db=m Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19099253&form=6&db=m Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma. causal interaction,unassigned 2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19393235&form=6&db=m Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways. causal interaction,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19400942&form=6&db=m Src, PKCalpha, and PKCdelta are required for alphavbeta3 integrin-mediated metastatic melanoma invasion. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19626679&form=6&db=m Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755418&form=6&db=m TPA inhibits melanoma growth by inactivation of STAT3 through PKC-activated tyrosine phosphatase(s). ongoing research,unassigned 2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19901340&form=6&db=m A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. unassigned - 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910471&form=6&db=m c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis. causal interaction,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20015121&form=6&db=m Functional alterations in protein kinase C beta II expression in melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145126&form=6&db=m Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20216103&form=6&db=m RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20629830&form=6&db=m Pharmacogenomics of metabotropic glutamate receptor subtype 1 and in vivo malignant melanoma formation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21389833&form=6&db=m VEGFR1 and PKC? signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner. therapeutic application,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21400668&form=6&db=m DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21685034&form=6&db=m Gastrointestinal stromal tumor markers in cutaneous melanomas: relationship to prognostic factors and outcome. diagnostic usage,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21906873&form=6&db=m Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22247259&form=6&db=m CD36 Ectodomain Phosphorylation Blocks Thrombospondin-1 Binding: Structure-Function Relationships and Regulation by Protein Kinase C. ongoing research,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22253748&form=6&db=m The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma. therapeutic application,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578192&form=6&db=m Specifying protein kinase C functions in melanoma. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22653968&form=6&db=m Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-?B Pathways. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23187006&form=6&db=m IFN?-mediated inhibition of cell proliferation through increased PKC?-induced overexpression of EC-SOD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563540&form=6&db=m The Phosphoinositide 3-Kinase? Selective Inhibitor, BYL719, Enhances the Effect of the Protein Kinase C Inhibitor, AEB071, in GNAQ/GNA11 Mutant Uveal Melanoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24595385&form=6&db=m Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation. therapeutic application,unassigned 2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959248&form=6&db=m Angiopoietin-like 4 promotes melanoma cell invasion and survival through aldolase A. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25304237&form=6&db=m GNAQ and GNA11 mutations in uveal melanoma. therapeutic application,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27507190&form=6&db=m Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma. therapeutic application,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056869&form=6&db=m Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28430130&form=6&db=m Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28436290&form=6&db=m Topography of Protein Kinase C ?II in Benign and Malignant Melanocytic Lesions. causal interaction,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28865485&form=6&db=m Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147206&form=6&db=m Antimetastatic Action of Pentoxifylline, a Methyl Xanthine Derivative, Through its Effect on PKC Mediated Integrin Transport in B16F10 Melanoma Cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29781749&form=6&db=m Oncogenic PKC-? activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-? and PKC-? specific inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30497386&form=6&db=m PKC? phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration. causal interaction,unassigned 3,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30525429&form=6&db=m Selective PKC? inhibitor B106 elicits uveal melanoma growth inhibitory effects independent of activated PKC isoforms. unassigned - 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31345992&form=6&db=m Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells. causal interaction,unassigned 1,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516713&form=6&db=m Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32029634&form=6&db=m Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033033&form=6&db=m WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion. unassigned - 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32898554&form=6&db=m Protein kinase C inhibitor anchored BRD4 PROTAC PEGylated nanoliposomes for the treatment of vemurafenib-resistant melanoma. therapeutic application,unassigned 4,0 2.7.11.13 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917514&form=6&db=m Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition. therapeutic application,unassigned 2,0 2.7.11.13 Melanoma, Amelanotic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7568126&form=6&db=m 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. ongoing research,unassigned 4,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319452&form=6&db=m Alpha-melanocyte-stimulating hormone stimulates protein kinase C activity in murine B16 melanoma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645360&form=6&db=m B16 mouse melanoma cells selected for resistance to cyclic AMP-mediated growth inhibition are cross-resistant to retinoic acid-induced growth inhibition. causal interaction,unassigned 2,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505261&form=6&db=m Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain. therapeutic application,unassigned 1,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2743337&form=6&db=m Induction of protein kinase C in mouse melanoma cells by retinoic acid. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422445&form=6&db=m Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8601745&form=6&db=m Enhanced expression of protein kinase C subspecies in melanogenic compartments in B16 melanoma cells by UVB or MSH. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8605013&form=6&db=m Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity. therapeutic application,unassigned 1,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8893841&form=6&db=m Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9007143&form=6&db=m Inhibition of B16 melanoma cell proliferation and alterations in p21 ras expression induced by interceptors of signal transduction pathways. ongoing research,unassigned 3,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344041&form=6&db=m Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9572888&form=6&db=m Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle. ongoing research,unassigned 3,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872567&form=6&db=m Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10486248&form=6&db=m Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10661772&form=6&db=m Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study. therapeutic application,unassigned 2,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11546757&form=6&db=m Protein kinase Calpha plays a critical role in mannosylerythritol lipid-induced differentiation of melanoma B16 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12514310&form=6&db=m Vitamin A (retinoids) regulation of mouse melanoma growth and differentiation. therapeutic application,unassigned 2,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527035&form=6&db=m Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18425734&form=6&db=m A short peptide is a protein kinase C (PKC) alpha-specific substrate. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19576939&form=6&db=m Phloridzin-induced melanogenesis is mediated by the cAMP signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19899099&form=6&db=m Protein kinase C activators as synaptogenic and memory therapeutics. causal interaction,unassigned 3,0 2.7.11.13 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689104&form=6&db=m Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25959522&form=6&db=m Towards universal therapeutics for memory disorders. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31233882&form=6&db=m Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32733207&form=6&db=m Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33093534&form=6&db=m Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7754836&form=6&db=m Involvement of protein kinase C in growth regulation of human meningioma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11215053&form=6&db=m The regulatory effects of protein kinase C on the proliferation of cultured human low-passage meningioma cells. ongoing research,unassigned 4,0 2.7.11.13 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12952950&form=6&db=m Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Mesenteric Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11490365&form=6&db=m Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. unassigned - 2.7.11.13 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765998&form=6&db=m Protein kinase C beta in malignant pleural mesothelioma. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21383961&form=6&db=m Role of protein kinase C ? and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism. therapeutic application,unassigned 2,0 2.7.11.13 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765998&form=6&db=m Protein kinase C beta in malignant pleural mesothelioma. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21383961&form=6&db=m Role of protein kinase C ? and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism. therapeutic application,unassigned 2,0 2.7.11.13 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370614&form=6&db=m Divergent effects of phorbol esters and insulin on insulin-like growth factor binding protein-1 (IGFBP-1) production and mRNA in rat H4IIE hepatoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25420887&form=6&db=m The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta. causal interaction,unassigned 1,0 2.7.11.13 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18294863&form=6&db=m Atypical protein kinase C dysfunction and the metabolic syndrome. causal interaction,unassigned 3,0 2.7.11.13 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20130736&form=6&db=m Renoprotective and blood pressure-lowering effect of dietary soy protein via protein kinase C betaII inhibition in a rat model of metabolic syndrome. ongoing research,unassigned 4,0 2.7.11.13 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25391456&form=6&db=m CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome. ongoing research,unassigned 1,0 2.7.11.13 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237474&form=6&db=m Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Metabolism, Inborn Errors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8347687&form=6&db=m Inhibition of protein kinase C activity in mucolipidosis type-4: a model for a new pathogenetic mechanism in inborn errors of metabolism. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Metabolism, Inborn Errors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8530533&form=6&db=m Possible role for protein kinase C in the pathogenesis of inborn errors of metabolism. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Metabolism, Inborn Errors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421686&form=6&db=m A model for PKC involvement in the pathogenesis of inborn errors of metabolism. ongoing research,unassigned 1,0 2.7.11.13 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30352990&form=6&db=m Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. causal interaction,unassigned 2,0 2.7.11.13 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22168364&form=6&db=m Protein kinase C-dependent activation of human K(2P) 18.1 K(+) channels. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206620&form=6&db=m Gabapentin inhibits central sensitization during migraine. causal interaction,unassigned 3,0 2.7.11.13 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28842814&form=6&db=m Protein Kinase C ? Contributes to Central Sensitization in a Rat Model of Chronic Migraine. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28990289&form=6&db=m Valproate Plays a Protective Role against Migraine by Inhibiting Protein Kinase C Signalling in Nitroglycerin-treated Mice. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34108435&form=6&db=m Protein kinase C? as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ongoing research,unassigned 4,0 2.7.11.13 Mitral Valve Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14619582&form=6&db=m [Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation] diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Mitral Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14619582&form=6&db=m [Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation] diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Mononeuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8410149&form=6&db=m Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Mononeuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592645&form=6&db=m Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy. causal interaction,unassigned 2,0 2.7.11.13 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9404713&form=6&db=m Activation of NMDA receptors and Ca2+/calmodulin-dependent protein kinase participate in phosphorylation of neurofilaments induced by protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649703&form=6&db=m Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease. ongoing research,unassigned 1,0 2.7.11.13 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789153&form=6&db=m Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16225760&form=6&db=m Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19928918&form=6&db=m Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells. causal interaction,unassigned 1,0 2.7.11.13 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30834833&form=6&db=m Resveratrol in Various Pockets: A Review. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Mucolipidoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8347687&form=6&db=m Inhibition of protein kinase C activity in mucolipidosis type-4: a model for a new pathogenetic mechanism in inborn errors of metabolism. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Mucolipidoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8902191&form=6&db=m Protein kinase C activation and phosphate uptake are altered in intact mucolipidosis type-4 skin fibroblasts. unassigned - 2.7.11.13 Mucopolysaccharidoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29916295&form=6&db=m Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751905&form=6&db=m Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation. causal interaction,unassigned 3,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12786795&form=6&db=m Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14644994&form=6&db=m GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. therapeutic application,unassigned 1,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17023575&form=6&db=m Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). causal interaction,unassigned 3,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17032922&form=6&db=m PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells. ongoing research,unassigned 4,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18028419&form=6&db=m Inhibitors of protein kinase C sensitise multiple myeloma cells to common genotoxic drugs. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18759374&form=6&db=m Molecular targeting of the PKC-beta inhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression. causal interaction,unassigned 4,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24180331&form=6&db=m A Multicenter Phase II Study of Single-agent Enzastaurin in Previously Treated Multiple Myeloma. therapeutic application,unassigned 3,0 2.7.11.13 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25828882&form=6&db=m Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10450792&form=6&db=m The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls. causal interaction,unassigned 3,0 2.7.11.13 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155525&form=6&db=m Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. ongoing research,unassigned 3,0 2.7.11.13 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15742114&form=6&db=m No evidence for association of the protein kinase C alpha gene with multiple sclerosis. causal interaction,unassigned 1,0 2.7.11.13 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19689371&form=6&db=m Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23904626&form=6&db=m Protein kinase C polymorphisms and vitamin D levels in multiple sclerosis. diagnostic usage,unassigned 3,0 2.7.11.13 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25080502&form=6&db=m Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis. unassigned - 2.7.11.13 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30005970&form=6&db=m Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Multiple System Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370069&form=6&db=m Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8478399&form=6&db=m Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage. ongoing research,unassigned 2,0 2.7.11.13 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9347985&form=6&db=m Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery. diagnostic usage,therapeutic application,unassigned 3,4,0 2.7.11.13 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276002&form=6&db=m Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina. therapeutic application,unassigned 1,0 2.7.11.13 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28529490&form=6&db=m Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes. unassigned - 2.7.11.13 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458880&form=6&db=m Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. causal interaction,unassigned 3,0 2.7.11.13 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159477&form=6&db=m Expression of protein kinase C isoforms and interleukin-1beta in myofibrillar myopathy. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25896919&form=6&db=m Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms. causal interaction,unassigned 2,0 2.7.11.13 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22348094&form=6&db=m PKC Theta Ablation Improves Healing in a Mouse Model of Muscular Dystrophy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659349&form=6&db=m Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes. unassigned - 2.7.11.13 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2073748&form=6&db=m Altered protein kinase C and protein kinase A activities in erythrocyte membrane, platelets and lymphocytes of Duchenne muscular dystrophy (DMD) patients. ongoing research,unassigned 1,0 2.7.11.13 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088891&form=6&db=m Importance of monitoring calcium & calcium related properties in carrier detection for Duchenne muscular dystrophy. diagnostic usage,unassigned 3,0 2.7.11.13 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547256&form=6&db=m Bryostatin 1, a novel antineoplastic agent and protein kinase C activator, induces human myalgia and muscle metabolic defects: a 31P magnetic resonance spectroscopic study. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630272&form=6&db=m Modulation of bryostatin 1 muscle toxicity by nifedipine: effects on muscle metabolism and oxygen supply. therapeutic application,unassigned 2,0 2.7.11.13 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17306466&form=6&db=m Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 2.7.11.13 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29672451&form=6&db=m Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Myasthenia Gravis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3359648&form=6&db=m Concanavalin A- or phorbol ester-induced translocation of protein kinase C in thymoma cells from a patient with myasthenia gravis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Myasthenia Gravis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17471566&form=6&db=m Antigen-specific T-cell activation in hyperplastic thymus in myasthenia gravis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 2.7.11.13 Myasthenia Gravis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32920588&form=6&db=m AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19380113&form=6&db=m Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1666555&form=6&db=m Sensitization of the beta-adrenergic system in acute myocardial ischaemia by a protein kinase C-dependent mechanism. causal interaction,unassigned 4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7602606&form=6&db=m Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. therapeutic application,unassigned 4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7606758&form=6&db=m Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit. unassigned - 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636421&form=6&db=m Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9441837&form=6&db=m Protein kinase C is involved in resistance to myocardial infarction induced by heat stress. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082262&form=6&db=m Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels. unassigned - 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10479656&form=6&db=m Selective activation of the prostanoid EP(3) receptor reduces myocardial infarct size in rodents. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10590241&form=6&db=m Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway. unassigned - 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668633&form=6&db=m Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710118&form=6&db=m Regional and temporal profiles of phorbol 12,13-dibutyrate binding after myocardial infarction in rats: effects of captopril treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11150400&form=6&db=m Cardioprotection induced by AT1R blockade after reperfused myocardial infarction: association with regional increase in AT2R, IP3R and PKCepsilon proteins and cGMP. unassigned - 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179083&form=6&db=m Essential activation of PKC-delta in opioid-initiated cardioprotection. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11527078&form=6&db=m Treatment with sheng-mai-san reduces myocardial infarct size through activation of protein kinase C and opening of mitochondrial KATP channel. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11967812&form=6&db=m Cardioprotection after angiotensin II type 1 blockade involves angiotensin II type 2 receptor expression and activation of protein kinase C-epsilon in acutely reperfused myocardial infarction in the dog. Effect of UP269-6 and losartan on AT1 and AT2-receptor expression and IP3 receptor and PKCepsilon proteins. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12061392&form=6&db=m Regulation of the isozymes of protein kinase C in the surviving rat myocardium after myocardial infarction: distinct modulation for PKC-alpha and for PKC-delta. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12383585&form=6&db=m The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts. causal interaction,unassigned 1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742831&form=6&db=m Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12909609&form=6&db=m Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits. causal interaction,unassigned 4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175555&form=6&db=m NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878171&form=6&db=m Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16716347&form=6&db=m PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785226&form=6&db=m Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17526775&form=6&db=m Dietary polyunsaturated fatty acids alter myocardial protein kinase C expression and affect cardioprotection induced by chronic hypoxia. unassigned - 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17655859&form=6&db=m Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. causal interaction,unassigned 2,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18242734&form=6&db=m Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19324912&form=6&db=m Time Courses of Subcellular Signal Transduction and Cellular Apoptosis in Remote Viable Myocardium of Rat Left Ventricles Following Acute Myocardial Infarction: Role of Pharmacomodulation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519579&form=6&db=m PKC delta and epsilon in drug targeting and therapeutics. therapeutic application,unassigned 4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19597978&form=6&db=m Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the phosphatidylinositol 3-kinase-Akt pathway. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19820255&form=6&db=m Ischemic preconditioning improves proteasomal activity and increases the degradation of {delta}PKC during reperfusion. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19914793&form=6&db=m The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20558438&form=6&db=m Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21692984&form=6&db=m K(ATP) channel agonists preserve connexin43 protein in infarcted rats by a protein kinase c-dependent pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22313801&form=6&db=m Inhibition of Protein Kinase C ? Ameliorates Impaired Angiogenesis in Type I Diabetic Mice Complicating Myocardial Infarction. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071564&form=6&db=m Protein kinase C ? expression in platelets from patients with acute myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,2 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26074368&form=6&db=m Brief pressure overload of the left ventricle reduces myocardial infarct size via activation of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648059&form=6&db=m Diabetes and Complications: Cellular Signalling Pathways, Current Understanding and Targeted Therapies. causal interaction,unassigned 4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26775707&form=6&db=m Overexpression of protein kinase C ? improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27586455&form=6&db=m Activating mu-opioid receptors in the spinal cord mediates the cardioprotective effect of remote preconditioning of trauma. diagnostic usage,unassigned 1,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713345&form=6&db=m Protein Kinases as Drug Development Targets for Heart Disease Therapy. causal interaction,unassigned 4,0 2.7.11.13 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28758099&form=6&db=m Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314557&form=6&db=m Enhanced membrane protein kinase C activity in myocardial ischemia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315640&form=6&db=m Alpha 1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylyl cyclase system. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154113&form=6&db=m Activation of myocardial protein kinase C by plasmalogenic diglycerides. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8160817&form=6&db=m Preconditioning protects ischemic rabbit heart by protein kinase C activation. therapeutic application,unassigned 2,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9286957&form=6&db=m Role of intracellular Ca2+ in activation of protein kinase C during ischemic preconditioning. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9821954&form=6&db=m Identification of specific nuclear protein kinase C isozymes and accelerated protein kinase C-dependent nuclear protein phosphorylation during myocardial ischemia. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9950866&form=6&db=m Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400913&form=6&db=m Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia. diagnostic usage,therapeutic application,unassigned 3,2,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436169&form=6&db=m Responses of cardiac protein kinase C isoforms to distinct pathological stimuli are differentially regulated. causal interaction,unassigned 3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630625&form=6&db=m Protein kinase C expression and subcellular distribution in chronic myocardial ischemia. Comparison of two different canine models. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133171&form=6&db=m Adenosine induced direct negative inotropic effect is abolished during global ischemia: role of protein kinase C and prostacyclin. unassigned - 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179034&form=6&db=m PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression. causal interaction,unassigned 1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304492&form=6&db=m Ischemic preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C epsilon in the rat ischemic myocardium. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11399253&form=6&db=m Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11602672&form=6&db=m Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes. therapeutic application,unassigned 3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11940366&form=6&db=m Association of the phosphatidylinositol signal pathway with prolonged myocardial ischemia. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11998814&form=6&db=m Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12160955&form=6&db=m Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel. therapeutic application,unassigned 4,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12386152&form=6&db=m Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo deltaPKC inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15699040&form=6&db=m Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. therapeutic application,unassigned 4,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16924416&form=6&db=m Dual mechanism of autoregulation of protein kinase C in myocardial ischemia. therapeutic application,unassigned 3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17360953&form=6&db=m Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17576073&form=6&db=m Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963639&form=6&db=m [Remote postconditioning by brief renal ischemia and reperfusion reduces acute myocardial ischemia and reperfusion induced myocardial apoptosis in rabbits] causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18155566&form=6&db=m Cardiopulmonary bypass with cardioplegic arrest activates protein kinase C in the human myocardium. causal interaction,unassigned 3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18706228&form=6&db=m Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685039&form=6&db=m Reciprocal regulation between M(3) muscarinic acetylcholine receptor and protein kinase C-epsilon in ventricular myocytes during myocardial ischemia in rats. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26887203&form=6&db=m [Effect of Electroacupuncture Stimulation of "Neiguan" (PC 6) on Expression of Myocardial Chloride Channel-related Genes, PKC and PKG Proteins in Myocardial Ischemia Rats]. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063287&form=6&db=m Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459379&form=6&db=m Pharmacological strategies to contend against myocardial reperfusion damage: diverse chemicals for multiple targets. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202667&form=6&db=m Protein kinase C isoform diversity in preconditioning. therapeutic application,unassigned 1,0 2.7.11.13 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9406164&form=6&db=m Phosphorylation by protein kinase C and the responsiveness of Mg(2+)-ATPase to Ca2+ of myofibrils isolated from stunned and non-stunned porcine myocardium. ongoing research,unassigned 1,0 2.7.11.13 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593774&form=6&db=m Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved. causal interaction,unassigned 4,0 2.7.11.13 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485783&form=6&db=m Isoflurane-enhanced recovery of canine stunned myocardium: role for protein kinase C? therapeutic application,unassigned 3,0 2.7.11.13 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11291597&form=6&db=m Role of oxidants in the signaling pathway of preconditioning. unassigned - 2.7.11.13 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962491&form=6&db=m Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Myosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12825834&form=6&db=m Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells. ongoing research,unassigned 4,0 2.7.11.13 Myotonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2446609&form=6&db=m Activators of protein kinase C induce myotonia by lowering chloride conductance in muscle. unassigned - 2.7.11.13 Myotonic Dystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2460293&form=6&db=m Linkage relationships of the protein kinase C gamma gene which exclude it as a candidate for myotonic dystrophy. causal interaction,unassigned 1,0 2.7.11.13 Myxoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12719581&form=6&db=m Role of the serine-threonine kinase PAK-1 in myxoma virus replication. unassigned - 2.7.11.13 nad(p)h oxidase (h2o2-forming) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23845067&form=6&db=m Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species-Studies in White Blood Cells and in Animal Models. causal interaction,unassigned 4,0 2.7.11.13 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12889099&form=6&db=m [Protein kinase C in eosinophil proliferation and infiltration in nasal polyp tissue] causal interaction,diagnostic usage,unassigned 1,2,0 2.7.11.13 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14570622&form=6&db=m Protein kinase C in proliferation and infiltration of eosinophils in nasal polyp. diagnostic usage,unassigned 3,0 2.7.11.13 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362676&form=6&db=m [The regulation of PKCalpha in eosinophil infiltration and proliferation in nasal polyps] causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.13 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15469081&form=6&db=m [The influence of protein kinase C inhibitor in eosinophil apoptosis of nasal polyps] causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708423&form=6&db=m Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus. causal interaction,unassigned 3,0 2.7.11.13 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778977&form=6&db=m A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: implications for radiosensitization and EBV-targeted therapy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.11.13 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11284734&form=6&db=m Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.7.11.13 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21878630&form=6&db=m N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells. causal interaction,unassigned 1,0 2.7.11.13 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062531&form=6&db=m Microtubule depolymerization activates the Epstein-Barr virus lytic cycle through protein kinase C pathways in nasopharyngeal carcinoma cells. unassigned - 2.7.11.13 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762847&form=6&db=m PKC? is a Potentially Useful Marker for Planning Individualized Radiotherapy for Nasopharyngeal Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Nasopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11284734&form=6&db=m Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.7.11.13 Nasopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15670898&form=6&db=m Cdc42/Rac1 participates in the control of telomerase activity in human nasopharyngeal cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1737379&form=6&db=m Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2061000&form=6&db=m Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496916&form=6&db=m Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422445&form=6&db=m Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511046&form=6&db=m Endogenous 12(S)-HETE production by tumor cells and its role in metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7658500&form=6&db=m Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7817999&form=6&db=m Analyses of protein kinase C isoform expression in a colorectal cancer liver metastasis model. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945369&form=6&db=m Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7991611&form=6&db=m Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8428364&form=6&db=m gamma-Interferon plays a key role in T-cell-induced tumor regression. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8433394&form=6&db=m Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8692033&form=6&db=m Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794871&form=6&db=m Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. causal interaction,unassigned 4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797581&form=6&db=m Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968075&form=6&db=m Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344041&form=6&db=m Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9387248&form=6&db=m [Inhibition of experimental metastasis and cell adhesion of B16 murine melanoma cells by protein kinase C inhibitor CJ9111] ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9644192&form=6&db=m The cytochromes P450 and mechanisms of chemical carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9652794&form=6&db=m Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10397270&form=6&db=m Protein kinase C delta involvement in mammary tumor cell metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523713&form=6&db=m The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review). causal interaction,unassigned 4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10729773&form=6&db=m Clustering of murine lung metastases reflects fractal nonuniformity in regional lung blood flow. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245008&form=6&db=m [An experimental study on the capability of laminin receptor antibody and protein kinase C inhibitor to inhibit tumor metastasis in vivo] causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11968018&form=6&db=m Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts. causal interaction,unassigned 2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12140376&form=6&db=m Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527035&form=6&db=m Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12539531&form=6&db=m [Expressions of five protein kinase C isoforms in salivary adenoid cystic carcinoma] causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14517342&form=6&db=m Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14683472&form=6&db=m Selective protein kinase C inhibitors and their applications. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009987&form=6&db=m [Cell membrane phospholipid variation and protein kinase C expression effects on hepatic metastasis of large intestinal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161701&form=6&db=m Pak-1 expression increases with progression of colorectal carcinomas to metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313680&form=6&db=m Effects of cell membrane phospholipid level and protein kinase C isoenzyme expression on hepatic metastasis of colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838606&form=6&db=m Scanning electrochemical microscopy: detection of human breast cancer cells by redox environment. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911217&form=6&db=m Effect of staurosporine on N-glycosylation and cell adhesion to fibronectin of SW480 human colorectal adenocarcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16283480&form=6&db=m KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740695&form=6&db=m SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with vascular endothelial growth factor inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17171646&form=6&db=m Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483345&form=6&db=m p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17630348&form=6&db=m Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17636410&form=6&db=m The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2. causal interaction,unassigned 3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855511&form=6&db=m Dual Actin-bundling and Protein Kinase C-binding Activities of Fascin Regulate Carcinoma Cell Migration Downstream of Rac and Contribute to Metastasis. causal interaction,unassigned 1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17922632&form=6&db=m The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18184652&form=6&db=m Protein Kinase C{epsilon} Mediates Polymeric Fibronectin Assembly on the Surface of Blood-borne Rat Breast Cancer Cells to Promote Pulmonary Metastasis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18224398&form=6&db=m Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer. ongoing research,unassigned 3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314869&form=6&db=m Overexpression of protein kinase Calpha mRNA may be an independent prognostic marker for gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701187&form=6&db=m Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132529&form=6&db=m Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201988&form=6&db=m Pivotal Advance: PKC{zeta} is required for migration of macrophages. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19326049&form=6&db=m Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis. diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379082&form=6&db=m mTOR in renal cell cancer: modulator of tumor biology and therapeutic target. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591825&form=6&db=m PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering. ongoing research,unassigned 4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903468&form=6&db=m Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179210&form=6&db=m Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20384629&form=6&db=m Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731935&form=6&db=m [The variation of intracellular distribution and translocation of the protein kinase C alpha among human lung cancer cell line with different metastasis potential.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20856202&form=6&db=m Sustained inhibition of PKC? reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21406403&form=6&db=m Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21878630&form=6&db=m N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22868505&form=6&db=m Localization of PKC? in Cell Membranes as a Predictor for Breast Cancer Response to Treatment. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24216982&form=6&db=m Protein kinase C epsilon and genetic networks in osteosarcoma metastasis. causal interaction,diagnostic usage,unassigned 2,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753582&form=6&db=m Control of MT1-MMP transport by atypical PKC during breast-cancer progression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26023164&form=6&db=m PKC? Is an Essential Mediator of Prostate Cancer Bone Metastasis. ongoing research,unassigned 3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26245668&form=6&db=m Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26276710&form=6&db=m Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884861&form=6&db=m Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28590507&form=6&db=m Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28631559&form=6&db=m PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28697177&form=6&db=m The TGF-? signalling negative regulator PICK1 represses prostate cancer metastasis to bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28865485&form=6&db=m Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29216867&form=6&db=m Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29312551&form=6&db=m Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30417717&form=6&db=m The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells. unassigned - 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31360197&form=6&db=m Inhibition of protein kinase C activity inhibits osteosarcoma metastasis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31524271&form=6&db=m Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration. causal interaction,unassigned 3,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033033&form=6&db=m WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion. unassigned - 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175276&form=6&db=m The Atypical Protein Kinase C Small Molecule Inhibitor ?-Stat, and Its Effects on Invasion Through Decreases in PKC-? Protein Expression. causal interaction,unassigned 4,0 2.7.11.13 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195807&form=6&db=m Prostasin regulates PD-L1 expression in human lung cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1280235&form=6&db=m Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1282723&form=6&db=m Tumor necrosis factor-alpha- and interleukin-1-stimulated intercellular adhesion molecule-1 expression by murine renal tubular epithelial cells is transcriptionally regulated and involves protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310490&form=6&db=m Increased phosphorylation of nuclear phosphoproteins in human lung-cancer cells resistant to cis-diamminedichloroplatinum (II). therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311643&form=6&db=m Enhancement of spermidine/spermine N1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312994&form=6&db=m Protein kinase C activation modulates tumour necrosis factor-alpha priming of human neutrophils for zymosan-induced leukotriene B4 release. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1316231&form=6&db=m Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320039&form=6&db=m Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322281&form=6&db=m Modulation of luteinizing hormone-stimulated inositol phosphate accumulation by phorbol esters in bovine luteal cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332686&form=6&db=m Opposite and independent actions of cyclic AMP and transforming growth factor beta in the regulation of type 1 plasminogen activator inhibitor expression. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335968&form=6&db=m Protein kinase C isoforms in human glioblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1345933&form=6&db=m Radiomimetic cell cycle delay induced by tetranodecanoyl phorbol acetate is enhanced by caffeine and by the protein kinase inhibitor 2-aminopurine. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1347251&form=6&db=m Protein kinase C isoforms in multidrug resistant P388/ADR cells: a possible role in daunorubicin transport. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1371088&form=6&db=m Tumor promoters induce basic fibroblast growth factor gene expression in human dermal fibroblasts. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379817&form=6&db=m Differential induction of 12-O-tetradecanoylphorbol-13-acetate sequence gene expression in murine melanocytes and melanoma cells. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1380511&form=6&db=m Inhibition of angiogenesis in vitro and in ovo with an inhibitor of cellular protein kinases, MDL 27032. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1394118&form=6&db=m Differential inhibition by staurosporine of phorbol ester, bryostatin and okadaic acid effects on mouse skin. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1399121&form=6&db=m Bile acids, non-phorbol-ester-type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1402129&form=6&db=m Effect of hyperthermia and protein kinase C inhibitors on DNA synthesis and cell proliferation on Ehrlich ascites tumour cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1412517&form=6&db=m Wy-14,643 stimulates hepatic protein kinase C activity. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1421577&form=6&db=m Phosphorylation of p90 and p52 in response to phorbol-esters in Swiss/3T3 cells overexpressing protein kinase C-alpha. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1423658&form=6&db=m The effects of staurosporine and okadaic acid on baby hamster kidney fibroblast cell adhesion. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1423867&form=6&db=m Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429092&form=6&db=m The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-ray-induced G2 arrest. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1435832&form=6&db=m Protein kinase C: implications for cancer prevention and treatment. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1437148&form=6&db=m Activation of the c-Raf protein kinase by protein kinase C phosphorylation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1453216&form=6&db=m Protein kinase C is activated and diacylglycerol is elevated in epidermal cells from Sencar mice fed high fat diets. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1454855&form=6&db=m Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1460280&form=6&db=m Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1472068&form=6&db=m Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1487145&form=6&db=m The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1493432&form=6&db=m Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1497612&form=6&db=m Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1504056&form=6&db=m Bryostatin 1 activates T cells that have antitumor activity. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1516053&form=6&db=m Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1526457&form=6&db=m Membrane-protein phosphorylation in the Bacillus subtilis cell cycle. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1528028&form=6&db=m Bryostatin 1-activated T cells can traffic and mediate tumor regression. diagnostic usage,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1528955&form=6&db=m Multistage carcinogenesis in mouse skin. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1531307&form=6&db=m Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1540240&form=6&db=m Activation of human leukemia protein kinase C by tumor promoters and its inhibition by N-trifluoroacetyladriamycin-14-valerate (AD 32). causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1540576&form=6&db=m Structural basis of protein kinase C activation by diacylglycerols and tumor promoters. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1545811&form=6&db=m The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1545816&form=6&db=m The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators. diagnostic usage,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1551913&form=6&db=m Alterations in the activity and regulation of mammalian ribonucleotide reductase by chlorambucil, a DNA damaging agent. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559225&form=6&db=m Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1562992&form=6&db=m The role of protein kinase C in migration of rat glioma cells from spheroid cultures. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1592108&form=6&db=m Tumorigenicity-associated expression of protein kinase C isoforms in rhabdomyosarcoma-derived cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1597853&form=6&db=m A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1618316&form=6&db=m Increase in protein kinase C activity is associated with human fibroblast growth inhibition. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1618838&form=6&db=m Increased expression of protein kinase C alpha plays a key role in retinoic acid-induced melanoma differentiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1628900&form=6&db=m Paradoxical stimulation and inhibition by protein kinase C modulating agents of lipopolysaccharide evoked production of tumour necrosis factor in human monocytes. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645360&form=6&db=m B16 mouse melanoma cells selected for resistance to cyclic AMP-mediated growth inhibition are cross-resistant to retinoic acid-induced growth inhibition. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645361&form=6&db=m Retinoic acid priming potentiates the induction of urokinase-type plasminogen activator by cyclic adenosine monophosphate in mouse mammary carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1648699&form=6&db=m Polyoma virus middle tumor antigen stimulates membrane-associated protein kinase C at lower levels than required for phosphatidylinositol kinase activation and neoplastic transformation. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653056&form=6&db=m NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases. diagnostic usage,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653779&form=6&db=m Toxicodynamics of tumour promoters of mouse skin. II. Binding to protein kinase C of some new diterpene esters and induction of luminol-enhanced chemoluminescence in mouse peritoneal neutrophils. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1656312&form=6&db=m Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657377&form=6&db=m Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1657956&form=6&db=m Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor. Comparison with receptor phosphorylation and functions affected by another tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1658377&form=6&db=m Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659633&form=6&db=m Membrane depolarization induces protein kinase C translocation and voltage operated calcium channel opening in PU5-1.8 cells. Protein kinase C as a negative feedback modulator for calcium signalling. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663450&form=6&db=m Mechanisms of action of okadaic acid class tumor promoters on mouse skin. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1688428&form=6&db=m Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693276&form=6&db=m Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696445&form=6&db=m Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1707932&form=6&db=m Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1717077&form=6&db=m Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1730238&form=6&db=m Effect of protein kinase C activators on the phosphorylation and the surface expression of the CDw50 leukocyte antigen. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1740006&form=6&db=m Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1741777&form=6&db=m Differential inhibition of epidermal growth factor binding by photoactivated psoralens and the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in cells overexpressing protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1746908&form=6&db=m Cremophor EL inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced protein phosphorylation in human myeloblastic leukemia ML-1 cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1750467&form=6&db=m An endothelial cell model for the investigation of the molecular regulation of fetal vascular tone. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1756233&form=6&db=m Specific regulation of the 100 kDa 2-5 A synthetase by protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1758601&form=6&db=m Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1773786&form=6&db=m Genetic studies on lung tumor susceptibility and histogenesis in mice. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1791639&form=6&db=m Protein kinase C stimulation enhances the process formation of adult oligodendrocytes and induces proliferation. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1801923&form=6&db=m Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1807790&form=6&db=m Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1820092&form=6&db=m New directions in cancer therapy based on aberrant expression of glycosphingolipids: anti-adhesion and ortho-signaling therapy. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847853&form=6&db=m Involvement of protein kinase C in regulating tumor necrosis factor alpha-stimulated progesterone production in rat preovulatory follicles in vitro. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1855195&form=6&db=m Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1868068&form=6&db=m Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1873801&form=6&db=m Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1873807&form=6&db=m Tumor promoter 12-O-tetradecanoylphorbol-13-acetate and sn-1,2-dioctanoylglycerol increase the phosphorylation of protein kinase C in cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1881614&form=6&db=m Protein kinase C in human pheochromocytoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1893379&form=6&db=m Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1903566&form=6&db=m Inhibitory effects of radical scavengers on diacylglycerol-promoted transformation in BALB/3T3 cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904062&form=6&db=m Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906437&form=6&db=m The involvement of protein kinase C, calcium, and 5-lipoxygenase in the production of tumor necrosis factor by a cloned interleukin-3 dependent cell line with natural cytotoxic activity. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906853&form=6&db=m Cytosolic-nuclear tumor promoter-specific binding protein: association with the 90 kDa heat shock protein and translocation into nuclei by treatment with 12-O-tetradecanoylphorbol 13-acetate. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910000&form=6&db=m Inhibition of Ehrlichia risticii infection in murine peritoneal macrophages by gamma interferon, a calcium ionophore, and concanavalin A. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910248&form=6&db=m Different susceptibility of lung cell lines to inhibitors of tumor promotion and inducers of differentiation. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1916896&form=6&db=m Tumour necrosis factor-alpha induces translocation of protein kinase C in tumour necrosis factor-sensitive cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1933883&form=6&db=m Immunological quantitation of levels of tissue inhibitor of metalloproteinase-1 in human colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1940380&form=6&db=m Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1949059&form=6&db=m Effects of lyngbyatoxin A from the blue-green alga Lyngbya majuscula on rabbit aorta contractions. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1959608&form=6&db=m Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1963404&form=6&db=m Activation of cyclic AMP phosphodiesterase by phorbol and protein kinase C pathway: differences in normal and diabetic tissue. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1967072&form=6&db=m Early events of fusion between Epstein Barr virus and human lymphoblastoid cells (Raji) detected by R18 fluorescence dequenching measurements. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974259&form=6&db=m Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1988078&form=6&db=m Reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2000399&form=6&db=m Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2001330&form=6&db=m The role of the phorbol ester receptor/protein kinase C in the sensitivity of leukemic cells to anthracyclines. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2002062&form=6&db=m Protein kinase C phosphorylates glutamyl-tRNA synthetase in rabbit reticulocytes stimulated by tumor promoting phorbol esters. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2007787&form=6&db=m Inhibition of mouse skin protein kinase C by benzoyl peroxide. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2009129&form=6&db=m Phorbol ester-induced tumor promotion by downregulation of protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2009306&form=6&db=m Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2018516&form=6&db=m Suppression of phorbol ester-enhanced radiation-induced malignancy in vitro by protease inhibitors is independent of protein kinase C. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2018537&form=6&db=m Effects of a fecapentaene on protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2022168&form=6&db=m Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2035759&form=6&db=m Testolactone, sulindac, warfarin, and vitamin K1 for unresectable desmoid tumors. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2043240&form=6&db=m Protein kinase C and the regulation of insulin secretion from pancreatic B cells. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2060628&form=6&db=m Inhibition of protein kinase C arrests proliferation of human tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2061000&form=6&db=m Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2069589&form=6&db=m Tumor cell adherence to cultured capillary endothelial cells is promoted by activators of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2107968&form=6&db=m Phorbol esters mediate phospholipid-free activation of rat brain protein kinase C. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2116001&form=6&db=m Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2117917&form=6&db=m Contrasting effects of the protein kinase C inhibitor, staurosporine, on cytokine and phorbol ester stimulation of fructose 2,6-bisphosphate and prostaglandin E production by fibroblasts in vitro. Comparative studies using interleukin-1 alpha, tumour necrosis factor alpha, transforming growth factor beta, interferon-gamma and 12-O-tetradecanoylphorbol 13-acetate. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123405&form=6&db=m Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2151306&form=6&db=m Translocation of protein kinase C from cytosol to membrane fractions in human epidermal keratinocytes by recombinant human interferon-gamma. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153382&form=6&db=m N-myristyl-Lys-Arg-Thr-Leu-Arg: a novel protein kinase C inhibitor. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154338&form=6&db=m Induction of protein kinase C activity by ultraviolet radiation. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156927&form=6&db=m Tumor necrosis factor signal transduction. Cell-type-specific activation and translocation of protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159348&form=6&db=m Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophils. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167234&form=6&db=m The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167919&form=6&db=m sn-1,2-diacylglycerol levels increase in progesterone-stimulated Xenopus laevis oocytes. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168707&form=6&db=m Cyclic AMP and calcium in mouse mammary tumour virus expression: effects and post-transcriptional site of action. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170384&form=6&db=m Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174362&form=6&db=m Okadaic acid activates microtubule-associated protein kinase in quiescent fibroblastic cells. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2176606&form=6&db=m Decrease in phorbol ester receptors in human brain tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2194521&form=6&db=m Protein kinase C and tumor promoters. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2198948&form=6&db=m [Complexes of phorbol tumor promoters with protein kinase C] therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2203949&form=6&db=m Tumor necrosis factor production by Kupffer cells requires protein kinase C activation. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2222428&form=6&db=m Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2222808&form=6&db=m Differing roles of protein kinase C on the antiproliferative effects of tumor necrosis factor alpha and beta on LoVo cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2222971&form=6&db=m Roles of protein kinase C on the mechanical activity of vascular smooth muscles. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2233127&form=6&db=m Lipid activators of protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2240190&form=6&db=m Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2242015&form=6&db=m Dissociation between protein kinase C content and biological responsiveness to phorbol esters in tumor promoter-sensitive (MCF-7) and resistant (RPh-4) cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2244911&form=6&db=m Protein kinase C inhibitors block the enhanced expression of intercellular adhesion molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factor. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2253220&form=6&db=m Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2253773&form=6&db=m The stereochemical requirement for protein kinase C activation by 3-methyldiglycerides matches that found in naturally occurring tumor promoters aplysiatoxins. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2265412&form=6&db=m Inhibition of mouse skin tumor promotion by adriamycin and daunomycin in combination with verapamil or palmitoylcarnitine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2288879&form=6&db=m Transformation by a ras oncogene causes increased expression of protein kinase C-alpha and decreased expression of protein kinase C-epsilon. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2294122&form=6&db=m Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2298741&form=6&db=m Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2302700&form=6&db=m Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2303531&form=6&db=m A novel succinyl dipeptide stimulates directed cell migration by modulating protein kinase C activity. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2304620&form=6&db=m Type-specific expression of protein kinase C isozymes in CNS tumor cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2311179&form=6&db=m The effects of teleocidin and aplysiatoxin tumor promoters on epithelial tight junctions and transepithelial permeability: comparison to phorbol esters. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2312612&form=6&db=m Protein kinase C levels and protein phosphorylation associated with inhibition of proliferation in a murine macrophage tumor. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2317779&form=6&db=m Changes in diacylglycerol and membrane associated protein kinase C activity reflect the growth status of xenografted human mammary carcinoma treated with 8-Cl-cAMP. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2318252&form=6&db=m Synergy of tumor necrosis factor with protein kinase C activators on T cell activation. diagnostic usage,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2340507&form=6&db=m Production of diacylglycerol, an activator of protein kinase C, by human intestinal microflora. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2344999&form=6&db=m Conversion of high grade lymphoma tumor cell line to intermediate grade with TPA and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2354444&form=6&db=m Regulation of protein kinase C by ionizing radiation. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2356754&form=6&db=m 12-O-tetradecanoylphorbol-13-acetate, a phorbol ester stimulating protein kinase C, inhibits bone resorption in vitro induced by parathyroid hormone and parathyroid hormone-related peptide of malignancy. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2386936&form=6&db=m Augmentation of cytotoxic effect of tumor necrosis factor on human immunodeficiency virus-infected cells by staurosporine, a potent protein kinase C inhibitor. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2388620&form=6&db=m Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2392322&form=6&db=m Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2393848&form=6&db=m Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2400822&form=6&db=m [Role of protein kinase C in cell regulation and tumor promotion] causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2412225&form=6&db=m Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2418358&form=6&db=m Protein kinase C activation induces conductance changes in Hermissenda photoreceptors like those seen in associative learning. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2422024&form=6&db=m Beta-adrenergic stimulation of anterior pituitary cyclic AMP is enhanced by tumor promoters. diagnostic usage,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2422391&form=6&db=m 12-O-tetradecanoylphorbol-13-acetate stimulates phosphorylation of the 58,000-Mr form of polyomavirus middle T antigen in vivo: implications for a possible role of protein kinase C in middle T function. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2432432&form=6&db=m Activation of protein kinase C augments evoked transmitter release. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2433906&form=6&db=m Phospholipid/calcium-dependent protein kinase (protein kinase C) system: a major site of bioregulation. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2435589&form=6&db=m Demonstration of protein kinase C activity in crustacean Y-organs, and partial definition of its role in regulation of ecdysteroidogenesis. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2435714&form=6&db=m Modulation of [3H]dihydropyridine receptors by activation of protein kinase C in chick muscle cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2449212&form=6&db=m Effect of protein kinase C activation on mast cell histamine release. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2450466&form=6&db=m Tumor-promoting phorbol esters induce angiogenesis in vivo. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2452080&form=6&db=m Role of protein kinase C in regulation of gene expression and relevance to tumor promotion. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469642&form=6&db=m Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469882&form=6&db=m Role of protein kinase C (PKC) in short- and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2471393&form=6&db=m Downregulation of tumor necrosis factor receptors of macrophages by interferons and interleukin-1. Role of protein kinase C activation. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2472983&form=6&db=m Opposing effects of calcium entry and phorbol esters on fusion of chick muscle cells. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2473407&form=6&db=m Tumor promoters accentuate phosphorylation of PO: evidence for the presence of protein kinase C in purified PNS myelin. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2474538&form=6&db=m Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2479163&form=6&db=m Effect of flavonoids on tumor promoter-induced basophil histamine release and protein kinase C. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494119&form=6&db=m Tumor prevention by a xanthate compound in experimental mouse-skin tumorigenesis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498255&form=6&db=m Lung cancer cells often express high levels of protein kinase C activity. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2498558&form=6&db=m The mechanism of skin tumor promotion caused by phorbol esters: possible involvement of arachidonic acid cascade/lipoxygenase, protein kinase C and calcium/calmodulin systems. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2500449&form=6&db=m Regulation of levels of IL-1 mRNA in human fibroblasts. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507191&form=6&db=m Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509065&form=6&db=m Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2511437&form=6&db=m A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2540997&form=6&db=m Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2543674&form=6&db=m Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544313&form=6&db=m Differential inhibition by staurosporine, a potent protein kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion, epidermal ornithine decarboxylase induction, hyperplasia and inflammation. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2544848&form=6&db=m Labile repressors are involved in the transcriptional control of PDGF-responsive genes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546729&form=6&db=m [The role of protein kinase C in tumor growth] causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548156&form=6&db=m Differential activation of the 21-base-pair enhancer element of human T-cell leukemia virus type I by its own trans-activator and cyclic AMP. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548292&form=6&db=m Cell genetic evidence of correlation of intracellular translocation of protein kinase C (PKC) and PKC-mediated phosphorylation of 80-kDa protein with mitogenic action of tumor promoters. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548715&form=6&db=m Altered function of protein kinase C and cyclic adenosine monophosphate-dependent protein kinase in a cell line derived from a mouse lung papillary tumor. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549043&form=6&db=m Protein phosphorylation associated with synergistic stimulation of neutrophils. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549124&form=6&db=m Effects of the tumor promoter, phorbol 12-myristate, 13-acetate, on the epidermal adenylate cyclase system: evidence for adenylate cyclase-regulation by protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549168&form=6&db=m Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2553289&form=6&db=m Inhibition by lipoxygenase inhibitors of 7-bromomethylbenz[a]anthracene-caused epidermal ornithine decarboxylase induction and skin tumor promotion in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555042&form=6&db=m Tumor promoters stimulate the formation of 1,2-diacylglycerol in murine peritoneal macrophages: a possible mechanism for stimulating superoxide anion radical production. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557245&form=6&db=m Protein kinase C phosphorylates DNA topoisomerase I. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2558300&form=6&db=m Tumor-promoting phorbol ester and ras oncogene expression inhibit the glucocorticoid-dependent transcription from the mouse mammary tumor virus long terminal repeat. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2561306&form=6&db=m Activation of protein kinase C via the T-cell receptor complex potentiates cyclic AMP responses in T-cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2562908&form=6&db=m Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2571412&form=6&db=m Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2577133&form=6&db=m Phosphoprotein, protein kinase C, and second-messenger system changes in human multidrug-resistant cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2583867&form=6&db=m Staurosporine stimulates expression of the urokinase-type (u-PA) plasminogen activator in LLC-PK1 cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2590208&form=6&db=m Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2592423&form=6&db=m Calcium-independent growth of human ovarian carcinoma cells. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2601739&form=6&db=m A mutant protein kinase C that can transform fibroblasts. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2602368&form=6&db=m Structural basis of protein kinase C activation by tumor promoters. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2610702&form=6&db=m Tumor promotion and depletion of protein kinase C in epidermal JB6 cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2613273&form=6&db=m Effects of pretreatment with protein kinase C activators on macrophage activation for tumor cytotoxicity, secretion of tumor necrosis factor, and its mRNA expression. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2627113&form=6&db=m Regulation of hepatocyte epidermal growth factor receptors by n-butyrate and dimethyl sulfoxide: sensitivity to modulation by the tumor promoter TPA. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2637248&form=6&db=m The effect of phorbol esters on cell growth and epidermal growth factor receptor modulation in a human gastric carcinoma cell line TMK-1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2639723&form=6&db=m Induction of protein kinase C translocation and cell differentiation in ML-1 human myeloblastic leukemic cells by tumor necrosis factor-alpha, transforming growth factor-beta, or tetradecanoylphorbol acetate. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2666979&form=6&db=m The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2669197&form=6&db=m Protein kinase C: a potential pathway of endothelial cell activation by endotoxin, tumor necrosis factor, and interleukin-1. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2676506&form=6&db=m Benzene-mediated protein kinase C activation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2679633&form=6&db=m Lack of correlation between translocation and biological effects mediated by protein kinase C: an appraisal. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2681576&form=6&db=m Monolayer freeze-fracture and scanning tunneling microscopy. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2687223&form=6&db=m Differential effects of tumor promoters on P210bcr-abl expression. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2696343&form=6&db=m The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2698671&form=6&db=m Protein kinase C and tumor promoters. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2706740&form=6&db=m Comparison of epidermal protein kinase C activity, ornithine decarboxylase induction and DNA synthesis stimulated by TPA or dioctanoylglycerol in mouse strains with differing susceptibility to TPA-induced tumor promotion. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2706741&form=6&db=m Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2708455&form=6&db=m Evidence for two pathways of protein kinase C induction of 2ar expression: correlation with mitogenesis. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2722787&form=6&db=m Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells. But hCG-induced desensitization does not involve protein kinase C activation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2737068&form=6&db=m [The role of protein kinase C in the adenylate cyclase activation by estradiol in the plasma membranes of estradiol-dependent tumors] causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2737267&form=6&db=m Changes in glycosaminoglycan sulfation and protein kinase C subcellular distribution during differentiation of the human colon tumor cell line Caco-2. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2743335&form=6&db=m Synthetic lipid second messenger sn-1,2-didecanoylglycerol: a complete tumor promoter in mouse skin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2745571&form=6&db=m Inositol 1,3,4,5-tetrakisphosphate stimulates the initiation of DNA synthesis in Ca2+-deprived rat liver cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2748684&form=6&db=m The protein kinase C pathway in tumor promotion. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2750486&form=6&db=m Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2768347&form=6&db=m Competence growth factors can cause modification in higher-order chromatin structure in mouse embryo 3T3 fibroblasts. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2775273&form=6&db=m Levels of protein kinase C activity in human gastrointestinal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2783420&form=6&db=m Inhibition of cytotoxic T lymphocyte-mediated lysis and cellular proliferation by isoquinoline sulfonamide protein kinase inhibitors. Evidence for the involvement of protein kinase C in lymphocyte function. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2784701&form=6&db=m Signal transduction events in in vitro megakaryocytopoiesis. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2785117&form=6&db=m Stimulation of a MR 80,000 protein phosphorylation by EGF in EGF receptor-hyperproducing human tumor cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2786455&form=6&db=m Regulation of transforming growth factor alpha messenger RNA expression in a chemically transformed rat hepatic epithelial cell line by phorbol ester and hormones. diagnostic usage,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2787934&form=6&db=m Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2790804&form=6&db=m Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2808535&form=6&db=m Subcellular distribution of protein kinase C/phorbol ester receptors in differentiating mouse keratinocytes. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820700&form=6&db=m Identification of amiloride-sensitive Na+/H+ exchange in rat NB2 node lymphoma cells. Stimulation by 12-O-tetradecanoyl-phorbol-13-acetate. diagnostic usage,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822466&form=6&db=m The involvement of catecholamines and polypeptide hormones in the multihormonal modulation of rat hepatic zinc thionein levels. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824656&form=6&db=m Downregulation of tumor necrosis factor (TNF) sensitivity via modulation of TNF binding capacity by protein kinase C activators. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830336&form=6&db=m Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833510&form=6&db=m Tumor necrosis factor receptors and cytocidal activity are down-regulated by activators of protein kinase C. diagnostic usage,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844156&form=6&db=m Studies on protein kinases involved in regulation of nucleocytoplasmic mRNA transport. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846301&form=6&db=m Differential effect on inositol-phospholipid hydrolysis, cytosolic-free Ca2+ concentration, protein kinase C activity and protein phosphorylation of 1-oleoyl-2-acetyl-sn-glycerol growth-stimulated ascites tumor cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846687&form=6&db=m Cholera toxin discriminates between murine T lymphocyte proliferation stimulated by activators of protein kinase C and proliferation stimulated by IL-2. Possible role for intracellular cAMP. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849046&form=6&db=m Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2851595&form=6&db=m Epidermal growth factor-stimulated DNA synthesis requires an influx of extracellular calcium. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2862049&form=6&db=m Phorbol esters affect pituitary growth hormone (GH) and prolactin release: the interaction with GH releasing factor, somatostatin and bromocriptine. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2870468&form=6&db=m Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2870684&form=6&db=m [The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion] diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2886871&form=6&db=m Effects of tumor promoters (mezerein, teleocidin and palytoxin) on growth hormone secretion from rat anterior pituitary cells cultured in monolayer. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2887282&form=6&db=m Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2895607&form=6&db=m Functional dissection of nuclear envelope mRNA translocation system: effects of phorbol ester and a monoclonal antibody recognizing cytoskeletal structures. diagnostic usage,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2917003&form=6&db=m Tumor-promoting phorbol esters stimulate bovine cerebral cortex capillary endothelial cell growth in vitro. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2917358&form=6&db=m Varied differentiation responses of human leukemias to bryostatin 1. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2924397&form=6&db=m The conformations and electrostatic potential maps of phorbol esters, teleocidins and ingenols. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2926838&form=6&db=m Role of protein kinase C in glial cell proliferation. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2930549&form=6&db=m Potentiation of diacylglycerol-activated protein kinase C by acyl-coenzyme A thioesters of hypolipidaemic drugs. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2933415&form=6&db=m Surface functions during mitosis in rat basophilic leukemia cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2957257&form=6&db=m Activation of distinct second messenger systems in anterior pituitary corticotrophic tumor cells alters the phosphorylation states of both shared and distinct cytosolic proteins. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983345&form=6&db=m Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988301&form=6&db=m Altered subcellular distribution of protein kinase C (a phorbol ester receptor). Possible role in tumor promotion and the regulation of cell growth: relationship to changes in adenylate cyclase activity. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2990454&form=6&db=m Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2992482&form=6&db=m Teleocidin and phorbol ester tumor promoters exert similar mitogenic effects on human lymphocytes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2995837&form=6&db=m Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2996780&form=6&db=m Protein kinase C phosphorylates pp60src at a novel site. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997213&form=6&db=m Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2998882&form=6&db=m Polymyxin B inhibits phorbol 12-myristate 13-acetate, but not chemotactic factor, induced effects in rabbit neutrophils. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000851&form=6&db=m Protein kinase C in adrenal cells: possible role in regulation of steroid synthesis. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3001110&form=6&db=m Regulation of the epidermal growth factor receptor by phosphorylation. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3001461&form=6&db=m Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3006042&form=6&db=m Intracellular activation of protein kinase C and regulation of the surface transferrin receptor by diacylglycerol is a spontaneously reversible process that is associated with rapid formation of phosphatidic acid. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3006705&form=6&db=m Cell membrane associated protein kinase C as receptor of diterpene ester co-carcinogens of the tumor promoter type and the phenotypic expression of tumors. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3008665&form=6&db=m [Possible modes of action of growth factors and tumor promoters in the activation of the c-myc gene in Swiss 3T3 fibroblasts] causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3008668&form=6&db=m [The role of protein kinase C in cell surface signal transduction and tumor promotion] causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011248&form=6&db=m Inhibition of chemotactic peptide-induced phosphoinositide hydrolysis by phorbol esters through the activation of protein kinase C in differentiated human leukemia (HL-60) cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3019351&form=6&db=m Ionic signal transduction in growth factor action. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3020435&form=6&db=m Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3022714&form=6&db=m Phorbol esters alter muscarinic receptor binding and inhibit polyphosphoinositide breakdown in human neuroblastoma (SH-SY5Y) cells. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023130&form=6&db=m Mesocestoides lineatus: trypsin induced development to adult mediated by Ca2+ and protein kinase C. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023484&form=6&db=m Interaction of IL 1 and TPA in modulation of eosinophil function. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026394&form=6&db=m Rapid modulation of tumor necrosis factor membrane receptors by activators of protein kinase C. diagnostic usage,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3027498&form=6&db=m Tumor promoters as probes of protein kinase C in dog thyroid cell: inhibition of the primary effects of carbamylocholine and reproduction of some distal effects. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3028416&form=6&db=m In-vitro modulation of protein kinase C activity by environmental chemical pollutants. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030855&form=6&db=m Inhibition by phorbol esters and other tumor promoters of the response of the Sertoli cell to FSH: evidence for dual site of action. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3034932&form=6&db=m Cellular signal transduction and the reversal of malignancy. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036247&form=6&db=m Bryostatins mimic the effects of phorbol esters in intact human platelets. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038883&form=6&db=m Regulation of protein kinase C by cyclic adenosine 3':5'-monophosphate and a tumor promoter in skeletal myoblasts. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3076326&form=6&db=m Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3078751&form=6&db=m The respiratory burst of granulocytes: modulation by inflammatory mediators and its mechanism. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3079908&form=6&db=m Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080229&form=6&db=m Activation of protein kinase C and specific phosphorylation of a Mr 90,000 membrane protein of promotable BALB/3T3 and C3H/10T1/2 cells by tumor promoters. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3083783&form=6&db=m [Factors controlling tumor promotion induced by TPA] causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3086122&form=6&db=m Membrane protein-lipid hydrogen bonding: evidence from protein kinase C, diglyceride, and tumor promotors. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3087762&form=6&db=m Early effects of TPA on protein kinase activity in murine thymocytes. Reduction of protein kinase C activity in the cytosol and increase of Ca2+ and phospholipid-independent kinase activity in the particulate fractions. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3091011&form=6&db=m Involvement of sulfatide in activation of protein kinase C by tumor promoters. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3092822&form=6&db=m Phorbol ester-induced alteration of protein kinase C catalytic properties occurs at the membrane level and is not reproduced by physiological stimuli. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093476&form=6&db=m Inhibition of queuine uptake in diploid human fibroblasts by phorbol-12,13-didecanoate. Requirement for a factor derived from early passage cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093574&form=6&db=m Role of protein kinase C and intracellular calcium mobilization in the induction of macrophage tumoricidal activity by interferon-gamma. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3094975&form=6&db=m Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099747&form=6&db=m Mechanism of hepatic glycogen synthase inactivation induced by Ca2+-mobilizing hormones. Studies using phospholipase C and phorbol myristate acetate. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3103602&form=6&db=m An inhibitory role for the protein kinase C pathway in ovarian steroidogenesis. Studies with cultured swine granulosa cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3106473&form=6&db=m Human T lymphocyte activation by tumor promoters: role of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108877&form=6&db=m Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3109978&form=6&db=m Epidermal growth factor and its receptor. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3114004&form=6&db=m The phorbol ester, TPA, increases transepithelial epidermal growth factor flux. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3122751&form=6&db=m Modulation of protein kinase C activity during inhibition of tumor cell growth by IFN-beta and -gamma. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123367&form=6&db=m Co-induction of lymphokine synthesis by the antineoplastic bryostatins. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3127039&form=6&db=m The protein kinase C activator L-alpha-dioctanoylglycerol: a potent stage II mouse skin tumor promoter. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3127041&form=6&db=m Phorbol ester-mediated association of protein kinase C to the nuclear fraction in NIH 3T3 cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3128291&form=6&db=m Cyclosporin A inhibits proteolytic cleavage and degradation of membrane-bound protein kinase C in hepatocytes after stimulation by phorbol ester. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3130194&form=6&db=m Abnormal T cells from MRL/Mp-lpr/lpr mice do not respond to anti-T-cell-receptor antibody or tumor promoter and calcium ionophore A23187 despite the presence of the T-cell-receptor complex and protein kinase c. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132168&form=6&db=m Protein kinase C modulates phospholipase C and increases arachidonic acid release in bradykinin stimulated MDCK cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132208&form=6&db=m [Translocation of protein kinase C from cytosol into cell membranes after treatment with estradiol and enzyme activation in target cells] ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3137176&form=6&db=m Protein kinase C activators of the teleocidin family decrease the IgE-binding capacity of rat basophilic leukemia cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3156004&form=6&db=m Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3156868&form=6&db=m Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3157441&form=6&db=m Modulation of protein kinase C activity and [3H]phorbol 12,13-dibutyrate binding by various tumor promoters in mouse brain cytosol. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3157448&form=6&db=m Phorbol ester-mediated protein phosphorylations in S49 mouse lymphoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3158214&form=6&db=m Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3158713&form=6&db=m Tumor promoter-stimulated protein phosphorylation in mouse epidermis is inhibited by bromophenacyl bromide. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3160457&form=6&db=m Rapid inhibition of intercellular communication between BALB/c 3T3 cells by diacylglycerol, a possible endogenous functional analogue of phorbol esters. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3162237&form=6&db=m Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3164220&form=6&db=m Modulation of cellular phorbol ester binding and/or protein kinase C activity by human placental fractions. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3192268&form=6&db=m Induction of EL4 cell resistance to syngeneic macrophage-mediated lysis by protein kinase C ligands; effects of cultured TPA-treated target cell and protein phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3196326&form=6&db=m Protein kinase C activities and bindings of a phorbol ester tumor promoter in 41 cell lines. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3196353&form=6&db=m Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3212670&form=6&db=m Nuclear protein kinase substrates in AtT-20 cells: translocation of a 14 kDa phosphoprotein. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3246672&form=6&db=m Protein kinase C activity in normal and neoplastic squamous epithelia from the upper aero-digestive tract. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3259583&form=6&db=m Mitogen-stimulated tyrosine phosphorylation of a 42-kD cellular protein: evidence for a protein kinase-C requirement. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3262104&form=6&db=m Growth factors rapidly induce expression of the glucose transporter gene. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3264029&form=6&db=m Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3275491&form=6&db=m Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3278915&form=6&db=m Protein kinase C is differentially regulated by thrombin, insulin, and epidermal growth factor in human mammary tumor cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3287845&form=6&db=m Chemical carcinogenesis: from animal models to molecular models in one decade. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3298968&form=6&db=m Hormone- and tumor promoter-induced activation or membrane association of protein kinase C in intact cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3314052&form=6&db=m [Possible role of protein kinase C in the T-lymphocyte cell cycle] unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3320756&form=6&db=m Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3335553&form=6&db=m Rapid phosphorylation of microtubule-associated proteins through distinct mitogenic pathways. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3342038&form=6&db=m Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3349487&form=6&db=m Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3353368&form=6&db=m Continuous synthesis of two protein-kinase-C-related proteins after down-regulation by phorbol esters. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3358773&form=6&db=m The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3360787&form=6&db=m Protein kinase C and its substrates in tumor promoter-sensitive and -resistant cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3402041&form=6&db=m The bile acid analog fusidic acid can replace phosphatidylserine in the activation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate in vitro. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3411820&form=6&db=m Comparison of some biochemical properties of epidermis in tumor promotion-susceptible and -resistant strains of mice. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422442&form=6&db=m Phorbol esters induce multidrug resistance in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3422445&form=6&db=m Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3423468&form=6&db=m Studies on the mechanism of action of protein kinase C and the isolation of molecular clones encoding the enzyme. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3434455&form=6&db=m Molecular geometries and steric energies of phorbol 10,11-diacetate and 1,2-diacetylglycerol molecules. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3444375&form=6&db=m A metabolite of an antineoplastic ether phospholipid may inhibit transmembrane signalling via protein kinase C. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3444377&form=6&db=m Ether lipids inhibit the effects of phorbol diester tumor promoters. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3461788&form=6&db=m Phorbol esters inhibit the proliferation of MCF-7 cells. Possible implication of protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3465725&form=6&db=m Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3465727&form=6&db=m Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3467028&form=6&db=m Increased diacylglycerol levels inhibit [20-3H]phorbol 12,13-dibutyrate binding and the glucocorticoid-mediated increase in glycerol phosphate phosphate dehydrogenase levels in C6 rat glioma cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3480042&form=6&db=m Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3484932&form=6&db=m Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3488993&form=6&db=m Antagonistic effects of phorbol esters on lymphocyte activation. Evidence that protein kinase C provides an early signal associated with lytic function. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3492269&form=6&db=m Growth state-dependent regulation of protein kinase C in normal and transformed murine cells. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3492494&form=6&db=m Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3498530&form=6&db=m Phorbol diester TPA elicits prostaglandin E release from cultured rat astrocytes. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3503440&form=6&db=m Phorbol esters that activate protein kinase C induce long-term changes of membrane excitability and postsynaptic currents in neocortical neurons. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3516146&form=6&db=m Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3516652&form=6&db=m Insulin stimulation of glucose metabolism in rat adipocytes: possible implication of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3584259&form=6&db=m Growth factors modify the epidermal growth factor receptor through multiple pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3594732&form=6&db=m Colony size, cell density and nature of the tumor promoter are critical variables in expression of a transformed phenotype (focus formation) in co-cultures of UV-TDTx and C3H10T1/2 cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3597547&form=6&db=m Parallel changes in amino acid transport and protein kinase C localization in LLC-PK1 cells treated with TPA or diradylglycerols. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3605367&form=6&db=m Effect of phorbol esters on contractile state and calcium flux in cultured chick heart cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3621472&form=6&db=m Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3670294&form=6&db=m Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3677312&form=6&db=m Benzoyl peroxide activation of protein kinase C activity in epidermal cell membranes. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3678377&form=6&db=m Inhibitory effects of tetradecanoylphorbol acetate and diacylglycerol on erythropoietin production in human renal carcinoma cell cultures. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3689124&form=6&db=m Studies on protein kinase C and colon carcinogenesis. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3689368&form=6&db=m Inhibition of protein kinase C by antineoplastic agents: implications for drug resistance. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3690506&form=6&db=m Sapintoxin A. A fluorescent phorbol ester that is a potent activator of protein kinase C but is not a tumour promoter. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3693364&form=6&db=m Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3693626&form=6&db=m Evidence for protein kinase C in bovine adrenocortical membrane preparations using [35S] gamma-thio-ATP as a phosphate donor. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3697380&form=6&db=m Characterization of protein tyrosine kinase activity in murine Leydig tumor cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3699159&form=6&db=m Protein phosphorylation in isolated mitochondria and the effects of protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3711103&form=6&db=m Phorbol ester- and Ca2+-dependent phosphorylation of human red cell membrane skeletal proteins. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3713854&form=6&db=m Phorbol ester facilitates 45Ca accumulation and catecholamine secretion by nicotine and excess K+ but not by muscarine in rat adrenal medulla. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3741437&form=6&db=m Activation of protein kinase C by ganglioside GM3 in the presence of calcium and 12-O-tetradecanoylphorbol-13-acetate. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3753017&form=6&db=m Gonadotropin release and redistribution of calcium-activated, phospholipid-dependent protein kinase in phorbol-stimulated rat pituitary cells. diagnostic usage,ongoing research,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3778969&form=6&db=m [Activation of protein kinase C and cAMP-dependent protein kinase in hormone-dependent mammary gland tumors during stimulation of their growth with progesterone and estrone] causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3779635&form=6&db=m Involvement of protein kinase C activation in ornithine decarboxylase gene expression in primary culture of newborn mouse epidermal cells and in skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3802403&form=6&db=m The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3814141&form=6&db=m Immunochemical characterization of protein kinase C in rat liver nuclei and subnuclear fractions. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3827900&form=6&db=m Tumor promoter chloroform is a potent protein kinase C activator. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3828992&form=6&db=m Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3862668&form=6&db=m Induction and desensitization of plasminogen activator gene expression by tumor promoters. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3862969&form=6&db=m A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3892533&form=6&db=m Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3927900&form=6&db=m The stimulation of prostaglandin production by transforming growth factor-alpha and 12-O-tetradecanoyl-phorbol-13-acetate or 1-oleoyl-2-acetyl-glycerol is synergistic. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3933562&form=6&db=m Phorbol myristate acetate induces endocytosis as well as exocytosis and hydroosmosis in toad urinary bladder. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3943605&form=6&db=m Phorbol esters inhibit low density lipoprotein processing by cultured human fibroblasts. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3949011&form=6&db=m Selective phosphorylation of human DNA methyltransferase by protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3963843&form=6&db=m [On the mechanisms of actions of tumor promoters] causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3986821&form=6&db=m Heterogeneity in responses of human and rodent respiratory epithelial cells to tumor promoters in culture. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4063970&form=6&db=m Phorbol ester-induced alteration of differentiation and proliferation in human hematopoietic tumor cell lines: relationship to the presence and subcellular distribution of protein kinase C. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4075290&form=6&db=m Phorbol ester activation of epidermal protein kinase C from tumor promotion sensitive and resistant mouse strains. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6092336&form=6&db=m Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6097580&form=6&db=m Membrane phospholipid turnover in signal transduction; protein kinase C and mechanism of action of tumor promoters. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6205401&form=6&db=m Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6229582&form=6&db=m B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6232463&form=6&db=m The role of protein kinase C in cell surface signal transduction and tumour promotion. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6233970&form=6&db=m Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6233978&form=6&db=m Activation of protein kinase C by non-phorbol tumor promoter, mezerein. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6235812&form=6&db=m The stereospecific activation of protein kinase C. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6238595&form=6&db=m Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6311812&form=6&db=m Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6320921&form=6&db=m Transmembrane signalling systems. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6328489&form=6&db=m Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6596101&form=6&db=m Inhibition of dimethylsulfoxide-induced differentiation in Friend erythroleukemic cells by diacylglycerols and phospholipase C. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6608349&form=6&db=m Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7474659&form=6&db=m TGF-beta and phorbol esters inhibit mitogenesis utilizing parallel protein kinase C-dependent pathways. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7476346&form=6&db=m Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7485529&form=6&db=m TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7497466&form=6&db=m Membrane and cytosolic protein phosphorylation patterns in the early stages of DEN-induced hepatocarcinogenesis in rats fed a high or low protein diet. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7505277&form=6&db=m Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7506638&form=6&db=m Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511046&form=6&db=m Endogenous 12(S)-HETE production by tumor cells and its role in metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511409&form=6&db=m Calcium and protein kinase C regulation of the glucocorticoid receptor in mouse corticotrope tumor cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7512497&form=6&db=m Parallel regulation of parentally imprinted H19 and insulin-like growth factor-II genes in cultured human fetal adrenal cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7514283&form=6&db=m Protein kinase C-dependent release of a functional whole extracellular domain of the mast cell growth factor (MGF) receptor by MGF-dependent human myeloid cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7515859&form=6&db=m Phorbol ester induced rapid attachment and spreading of melanoma cells and the role of extracellular matrix proteins. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7518003&form=6&db=m 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521351&form=6&db=m Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7523602&form=6&db=m Appearance of depolarization- and maitotoxin-induced [Ca2+]i elevation in single LAN-1 human neuroblastoma cells on exposure to retinoic acid. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7524603&form=6&db=m Calcium-dependent photodynamic action of di- and tetrasulphonated aluminium phthalocyanine on normal and tumour-derived rat pancreatic exocrine cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7527412&form=6&db=m Effects of pituitary adenylate cyclase-activating polypeptide on hormone secretion by human pituitary adenomas in vitro. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7527452&form=6&db=m Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7530504&form=6&db=m Tumor necrosis factor alpha induces endothelial galactosyl transferase activity and verocytotoxin receptors. Role of specific tumor necrosis factor receptors and protein kinase C. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7538287&form=6&db=m TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7539423&form=6&db=m Activation of NADPH-oxidase and its associated whole-cell H+ current in human neutrophils by recombinant human tumor necrosis factor alpha and formyl-methionyl-leucyl-phenylalanine. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7540894&form=6&db=m Bryostatin 1 enhances lymphokine activated killer sensitivity and modulates the beta 1 integrin profile of cultured human tumor cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7541474&form=6&db=m PKA and PKC activation induces opposite glial fibrillary acidic protein (GFAP) expression and morphology changes in a glioblastoma multiform cell line of clonal origin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7542754&form=6&db=m Regulation of U-937 monocyte adhesion to cultured human mesangial cells by cytokines and vasoactive agents. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7559098&form=6&db=m Activation of protein kinase C by mycobacterial cord factor, trehalose 6-monomycolate, resulting in tumor necrosis factor-alpha release in mouse lung tissues. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7562546&form=6&db=m New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585521&form=6&db=m Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585585&form=6&db=m Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7590881&form=6&db=m Entamoeba histolytica stimulates the unstable transcription of c-fos and tumour necrosis factor-alpha mRNA by protein kinase C signal transduction in macrophages. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7590896&form=6&db=m IL-8 enhances antibody-dependent cellular cytotoxicity in human neutrophils. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7628394&form=6&db=m Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7632434&form=6&db=m Effect of benzoyl peroxide on protein kinase C in cultured human epidermal keratinocytes. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7640233&form=6&db=m A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7658500&form=6&db=m Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7663699&form=6&db=m Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7672124&form=6&db=m Wortmannin has opposite effects on phorbol ester-induced DNA synthesis and phosphatidylcholine hydrolysis. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681061&form=6&db=m Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7683925&form=6&db=m Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7686753&form=6&db=m A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7686894&form=6&db=m A tumor promoter-resistant subpopulation of progenitor cells is larger in limbal epithelium than in corneal epithelium. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690717&form=6&db=m The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7693681&form=6&db=m Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7694875&form=6&db=m Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7705931&form=6&db=m Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7712599&form=6&db=m Regulation of protein kinase C and role in cancer biology. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713907&form=6&db=m Irreversible inactivation of protein kinase C by a peptide-substrate analog. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7717978&form=6&db=m The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7724734&form=6&db=m Heterogeneity in c-jun gene expression in normal and malignant cells exposed to either ionizing radiation or hydrogen peroxide. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7727042&form=6&db=m Inhibition of ras p21 membrane localization and modulation of protein kinase C isozyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733936&form=6&db=m The protein kinase C inhibitor, bisindolylmaleimide, inhibits the TPA-induced but not the TNF-induced increase in LLC-PK1 transepithelial permeability. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7744317&form=6&db=m Oxidative mechanisms in the toxicity of metal ions. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7761353&form=6&db=m The role of 80K/MARCKS, a specific substrate of protein kinase C, in cell growth and tumour progression. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7767990&form=6&db=m Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7782924&form=6&db=m Dietary modulation of epidermal protein kinase C: mediation by diacylglycerol. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7784066&form=6&db=m Overexpression of PKC zeta in NIH3T3 cells does not induce cell transformation nor tumorigenicity and does not alter NF kappa B activity. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7784716&form=6&db=m Stimulatory effect of 1 alpha,25-dihydroxyvitamin D3 on mouse alveolar macrophage tumor necrosis factor-alpha production in vitro: involvement of protein kinase C and Ca2+/calmodulin-dependent kinase. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7785505&form=6&db=m Protein kinase C in cell signaling: strategies for the development of selective inhibitors. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7789317&form=6&db=m Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7789532&form=6&db=m Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7814423&form=6&db=m Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7834620&form=6&db=m Translocation and activation of protein kinase C by the plasma cell tumor-promoting alkane pristane. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7838340&form=6&db=m Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7861778&form=6&db=m Differential expression of protein kinase C isoforms in human colorectal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7893369&form=6&db=m Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7894192&form=6&db=m An immunohistochemical study of glucagonoma conducted on the metastatic lymph nodes from a patient with recurrent metastatic glucagonoma: report of a case. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7894203&form=6&db=m Phorbol ester tumor promoter regulation of natural antitumor antibody binding depends on protein kinase C and an intact microfilament system. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7916897&form=6&db=m Effect of suramin on adenylate cyclase and protein kinase C. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7923549&form=6&db=m Signaling and drug sensitivity. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7929104&form=6&db=m Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes. Autocrine role of tumor necrosis factor alpha. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931075&form=6&db=m Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931620&form=6&db=m The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7934626&form=6&db=m Expression of six protein kinase C isotypes in endothelial cells. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943255&form=6&db=m Activation of protein kinase C mediates altered pulmonary vasoreactivity induced by tumor necrosis factor-alpha. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943258&form=6&db=m Tumor necrosis factor-alpha decreases pulmonary artery endothelial nitrovasodilator via protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945369&form=6&db=m Modulation of human melanoma cell metastasis and adhesion may involve integrin phosphorylation mediated through protein kinase C. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945801&form=6&db=m Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7954449&form=6&db=m c-fos promoter insensitivity to phorbol ester and possible role of protein kinase C in androgen-independent cancer cells. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7954524&form=6&db=m Immunomodulation in patients receiving intravenous Bryostatin 1 in a phase I clinical study: comparison with effects of Bryostatin 1 on lymphocyte function in vitro. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7957236&form=6&db=m Signal-transduction therapy. A novel approach to disease management. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7957257&form=6&db=m Human antioxidant-response-element-mediated regulation of type 1 NAD(P)H:quinone oxidoreductase gene expression. Effect of sulfhydryl modifying agents. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7991611&form=6&db=m Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7999261&form=6&db=m Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8001237&form=6&db=m Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8004692&form=6&db=m Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8010039&form=6&db=m [Inhibitory effects of protein kinase C inhibitor and calmodulin antagonist on tumor necrosis factor production by mouse macrophages] ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8018413&form=6&db=m H7, an inhibitor of protein kinase C, inhibits tumour cell division in mice bearing ascitic Ehrlich's carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8023339&form=6&db=m Strain-related differences in the pneumotoxic effects of chronically administered butylated hydroxytoluene on protein kinase C and calpain. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8034618&form=6&db=m Reduced insulin receptor expression and function in human colonic Caco-2 cells by ras and polyoma middle T oncogenes. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8038218&form=6&db=m Activation of protein kinase C during cell volume regulation in Ehrlich mouse ascites tumor cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040024&form=6&db=m Ketoconazole attenuates radiation-induction of tumor necrosis factor. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8056632&form=6&db=m Atrial natriuretic factor inhibits the phosphorylation of protein kinase C in plasma membrane preparations of cultured Leydig tumor cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8058522&form=6&db=m Dietary fatty acids and breast cancer invasion and metastasis. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8063765&form=6&db=m Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-alpha-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8067998&form=6&db=m Regulation of mammalian ribonucleotide reductase R1 mRNA stability is mediated by a ribonucleotide reductase R1 mRNA 3'-untranslated region cis-trans interaction through a protein kinase C-controlled pathway. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8080441&form=6&db=m Comparison of different tumour promoters and bryostatin 1 on protein kinase C activation and down-regulation in rat renal mesangial cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8086283&form=6&db=m Free cholesterol induces activation but not translocation of protein kinase C in cultured ascites tumour cells. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8087865&form=6&db=m Inhibition of PMA-induced human T cell proliferation by bryostatin is associated with enhanced degradation of conventional protein kinase C (cPKC): Ca2+ signals restore mitogenic activity without abrogating enhanced cPKC degradation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8090056&form=6&db=m The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8093352&form=6&db=m Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8094032&form=6&db=m Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8097303&form=6&db=m Immunohistochemical expression of protein kinase C type III in human pituitary adenomas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8108142&form=6&db=m Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8111733&form=6&db=m Malignant melanoma: from subcutaneous nodule to brain metastasis. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117276&form=6&db=m Potentiation of glucocorticoid-mediated induction of the mouse mammary tumor virus promoter in mammary carcinoma cells by activation of protein kinase C. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8127941&form=6&db=m Long-wave ultraviolet radiation induces protein kinase C in normal human keratinocytes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8130084&form=6&db=m Differing roles of protein kinase C on the signal transduction of tumour necrosis factor-alpha and -beta on PANC-1 cells: in vitro autoradiographic investigation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8131680&form=6&db=m Protein kinase C activity as a potential marker for colorectal neoplasia. diagnostic usage,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8134292&form=6&db=m Gastrin's trophic effect in the colon: identification of a signaling pathway mediated by protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8135859&form=6&db=m Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8142015&form=6&db=m Expression in lung tumors and genetic mapping of the novel murine protein kinase C eta. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8143904&form=6&db=m Involvement of protein kinase C and protein tyrosine kinase pathways in tumor necrosis factor-alpha-induced clustering of ovarian theca-interstitial cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144186&form=6&db=m The effect of bryostatin on protein kinase C-regulated functions in human T lymphocytes and epidermal keratinocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8148055&form=6&db=m Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8149496&form=6&db=m Five of six protein kinase C isoenzymes present in normal mucosa show reduced protein levels during tumor development in the human colon. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8155779&form=6&db=m [The effect of alpha-tocopherol over a wide range of concentrations (10(-2)-10(-17) M) on protein kinase C activity. Connection with proliferation and tumor growth] ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8162345&form=6&db=m Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8174128&form=6&db=m Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8180127&form=6&db=m Differential expression of protein kinase C isozyme messenger RNAs in dunning R-3327 rat prostatic tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188084&form=6&db=m Protein kinase C-dependent and -independent pathways mediate epidermal growth factor (EGF) effects in human endometrial adenocarcinoma cell line KLE. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188761&form=6&db=m Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8197153&form=6&db=m Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8204888&form=6&db=m Regulation of 92-kD gelatinase release in HL-60 leukemia cells: tumor necrosis factor-alpha as an autocrine stimulus for basal- and phorbol ester-induced secretion. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8209376&form=6&db=m Peroxisomal proliferators inhibit acyl CoA synthetase and stimulate protein kinase C in vivo. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8230261&form=6&db=m Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8239502&form=6&db=m Differential effects of 12-O-tetradecanoyl-13-phorbol acetate (TPA) on growth, migration and invasion of a human glioma cell line. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253522&form=6&db=m Ability of the non-phorbol ester-type tumor-promoter thapsigargin to mimic the stimulatory effects of 12-0-tetradecanoylphorbol-13-acetate on ornithine decarboxylase activity, hydroperoxide production, and macromolecule synthesis in mouse epidermis in vivo. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253722&form=6&db=m Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8270608&form=6&db=m Stimulation of prostaglandin E2 production and induction of specific protein synthesis in rat peritoneal macrophages by a tumor promoter staurosporine. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8270858&form=6&db=m Zanvil Alexander Cohn 1926-1993. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276122&form=6&db=m Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2. Role of protein kinase C. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8280742&form=6&db=m Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8284209&form=6&db=m Ets transcription factor binding site is required for positive and TNF alpha-induced negative promoter regulation. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8289454&form=6&db=m The effect of sulindac on colon polyps: circumvention of a transformed phenotype--a hypothesis. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8297119&form=6&db=m Mechanism of growth inhibition of mammary carcinomas by glucarate and the glucarate: retinoid combination. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8313370&form=6&db=m Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8314307&form=6&db=m Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8314539&form=6&db=m Enhancement of antiproliferative effect of cis-diamminedichloroplatinum(II) by clomiphene and tamoxifen in human ovarian cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8314789&form=6&db=m Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8325335&form=6&db=m Nocardia fractions, NLD and NWSM, induce tumor necrosis factor-alpha secretion in human monocytes: role of protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8350491&form=6&db=m Anticarcinogenic activity of green tea polyphenols. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8352018&form=6&db=m [Effects of protein kinase C activator and inhibitor on release of tumor necrosis factor from mouse peritoneal macrophages] ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8363661&form=6&db=m 12-O-tetradecanoylphorbol-13-acetate and staurosporine induce increased retinoblastoma tumor suppressor gene expression with megakaryocytic differentiation of leukemic cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380863&form=6&db=m Activation of protein kinase C rapidly down-regulates naloxone-resistant receptors for beta-endorphin on U937 cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383675&form=6&db=m Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384457&form=6&db=m Induction of superoxide by 12-O-tetradecanoylphorbol-13-acetate and thapsigargin, a non-phorbol-ester-type tumor promoter, in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: a permissive role for the arachidonic acid cascade in signal transduction. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388319&form=6&db=m Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388998&form=6&db=m Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390801&form=6&db=m Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8399765&form=6&db=m [Five classes of anticarcinogens--phorbol ester antagonists] unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8402625&form=6&db=m Regulation of protein kinase C isozymes in kidney regeneration. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8404381&form=6&db=m Decreased levels of protein kinase C enzyme activity and protein kinase C mRNA in primary colon tumors. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8404625&form=6&db=m The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate stimulates the dephosphorylation of mitochondrial ferredoxin in cultured chick kidney cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408180&form=6&db=m Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408643&form=6&db=m Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8409524&form=6&db=m Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8417617&form=6&db=m Regulation of the 12-O-tetradecanoyl-phorbol-13-acetate-induced inhibition of intercellular communication. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8424690&form=6&db=m Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8428364&form=6&db=m gamma-Interferon plays a key role in T-cell-induced tumor regression. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8428724&form=6&db=m Hyaluronic acid uptake by the isolated, perfused rat liver: an index of hepatic sinusoidal endothelial cell function. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8430818&form=6&db=m Tumor necrosis factor-alpha activates pulmonary artery endothelial protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8431975&form=6&db=m 1-dehydro-melengestrol acetate inhibits the growth and protein kinase C activity of androgen-independent Dunning rat prostatic tumors. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8433394&form=6&db=m Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8434650&form=6&db=m Protein kinase C (PKC) activity and PKC messenger RNAs in human pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8435862&form=6&db=m Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8439947&form=6&db=m Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8442751&form=6&db=m Protein kinase C: a key factor in the regulation of tumor cell adhesion to the endothelium. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8448165&form=6&db=m Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and modes of enzyme inhibition. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8449916&form=6&db=m Protein kinase C activation without membrane contact in platelets stimulated by bryostatin. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8454583&form=6&db=m Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8455596&form=6&db=m Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. diagnostic usage,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8462284&form=6&db=m Insulin induction of c-Ki-ras in rat liver and in cultured normal rat hepatocytes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8472338&form=6&db=m Comparison of 12-O-tetradecanoylphorbol-13-acetate and teleocidin for induction of epidermal hyperplasia, activation of epidermal PKC isozymes and skin tumor promotion in SENCAR and C57BL/6 mice. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8473055&form=6&db=m Role of protein kinase C and cytokines on the function and production of cytolytic granules in alpha CD3-activated killer-cell-mediated killing of tumor cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8478489&form=6&db=m Effects of ultraviolet-B and PUVA on ornithine decarboxylase activity, DNA synthesis, and protein kinase C activity in mouse skin. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8479155&form=6&db=m Protein kinase C activity and messenger RNA modulation by estrogen in normal and neoplastic rat pituitary tissue. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8482337&form=6&db=m Effect of the tumor promoter phorbol 12-myristate 13-acetate (PMA) on proliferation of young and senescent WI-38 human diploid fibroblasts. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8492304&form=6&db=m Na+, K+, Cl- cotransport and its regulation in Ehrlich ascites tumor cells. Ca2+/calmodulin and protein kinase C dependent pathways. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8496137&form=6&db=m A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8499489&form=6&db=m Insulin and platelet-derived growth factor acutely stimulate glucose transport in 3T3-L1 fibroblasts independently of protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8503882&form=6&db=m Depletion of tumour glutathione in vivo by buthionine sulphoximine: modulation by the rate of cellular proliferation and inhibition of cancer growth. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8509434&form=6&db=m Molecular and cellular features of esophageal cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8530184&form=6&db=m Interleukin 1-beta- and tumor necrosis factor-alpha-mediated regulation of ICAM-1 gene expression in astrocytes requires protein kinase C activity. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8532708&form=6&db=m Skin carcinogenesis: characteristics, mechanisms, and prevention. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8532710&form=6&db=m The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8538624&form=6&db=m Protein kinase C and skin tumor promotion. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8554927&form=6&db=m Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8556715&form=6&db=m Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8580367&form=6&db=m Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8580531&form=6&db=m Opposite effects of interleukin-2 (IL-2) and interferon gamma (IFN gamma) on rat atria contractility. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595146&form=6&db=m Potential for protein kinase C inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595959&form=6&db=m Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8603392&form=6&db=m Identification and characterization of a radiation-inducible glycosylated human early-response gene. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8604257&form=6&db=m Inductive effect of Porphyromonas gingivalis fimbriae on differentiation of human monocytic tumor cell line U937. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615643&form=6&db=m MAPK activity is down-regulated in human colon adenocarcinoma: correlation with PKC activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8615646&form=6&db=m Assessment of the metastatic ability of rat hepatoma cells in chick embryos by the polymerase-chain reaction. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8622871&form=6&db=m Linking protein kinase C to the cell cycle: ectopic expression of PKC eta in NIH3T3 cells alters the expression of cyclins and Cdk inhibitors and induces adipogenesis. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627883&form=6&db=m Tumor necrosis factor mediates apoptosis via Ca++/Mg++ dependent endonuclease with protein kinase C as a possible mechanism for cytokine resistance in human renal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630022&form=6&db=m Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8645257&form=6&db=m UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8655632&form=6&db=m Okadaic acid, sphingosine, and phorbol ester reversibly modulate heat induction on protein kinase FA/GSK-3 alpha in A431 cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8661342&form=6&db=m Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8676754&form=6&db=m Up-regulation of intracellular signalling pathways may play a central pathogenic role in hypertension, atherogenesis, insulin resistance, and cancer promotion--the 'PKC syndrome'. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8692033&form=6&db=m Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8699481&form=6&db=m Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700110&form=6&db=m Effect of phorbol myristate acetate on alpha 1-adrenergic action in cells expressing recombinant alpha 1-adrenoceptor subtypes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8700129&form=6&db=m Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8709978&form=6&db=m Induction of early growth response-1 gene by interleukin-1 beta and tumor necrosis factor-alpha in normal human bone marrow stromal an osteoblastic cells: regulation by a protein kinase C inhibitor. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8732044&form=6&db=m Protein kinase C inhibitor H-7 blocks effects of tumor necrosis factor on bone cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8739563&form=6&db=m Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8758918&form=6&db=m Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8761473&form=6&db=m Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769390&form=6&db=m Nonfunctioning adenomas of the pituitary. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8790599&form=6&db=m Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8794871&form=6&db=m Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797581&form=6&db=m Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8806429&form=6&db=m Differential secretion of cathepsins B and L from normal and tumor human lung cells stimulated by 12(S)-hydroxy-eicosatetraenoic acid. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8806446&form=6&db=m Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809413&form=6&db=m Localization of protein kinase C alpha isoform expression in the human gastrointestinal tract. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8825421&form=6&db=m Calphostin C induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in a pathway independent of tumor promoter phorbol ester-mediated down-regulation of protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8826855&form=6&db=m Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8835289&form=6&db=m The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8837815&form=6&db=m Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8856479&form=6&db=m Tumor necrosis factor-alpha, platelet-activating factor, and hydrogen peroxide activate protein kinase C subtypes alpha and epsilon in human saphenous vein endothelial cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8877100&form=6&db=m Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8878412&form=6&db=m Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8887448&form=6&db=m Potent peroxisome proliferators inhibit beta-oxidation in the isolated perfused rat liver. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8895766&form=6&db=m Human prostate carcinoma cells express functional alphaIIb(beta)3 integrin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8895992&form=6&db=m Diet intervention for modifying cancer risk. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898728&form=6&db=m Intracellular signaling of tumor necrosis factor-alpha in brain microvascular endothelial cells is mediated by a protein tyrosine kinase and protein kinase C-dependent pathway. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8912814&form=6&db=m Protein kinase C (PKC) isoenzyme expression pattern as an indicator of proliferative activity in uterine tumor cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8929245&form=6&db=m Antitumor activity of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on murine and human tumor models. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8939949&form=6&db=m Regulation of cyclooxygenases by protein kinase C. Evidence against the importance of direct enzyme phosphorylation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8946606&form=6&db=m Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964400&form=6&db=m Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8968046&form=6&db=m Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8969921&form=6&db=m Molecular strategies for the dominant inhibition of protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8972728&form=6&db=m The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973661&form=6&db=m Structure/activity relationships of polyfunctional diterpenes of the tigliane type. A pharmacophore model for protein-kinase-C activators based on structure/activity studies and molecular modeling of the tumor promoters 12-O-tetradecanoylphorbol 13-acetate and 3-O-tetradecanoylingenol. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8976194&form=6&db=m Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8977340&form=6&db=m Antiproliferative effects of interferon alpha on human pancreatic carcinoma cell lines are associated with differential regulation of protein kinase C isoenzymes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8989914&form=6&db=m Multifactor regulation of prostaglandin H synthase-2 in murine keratinocytes. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8999887&form=6&db=m Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8999958&form=6&db=m Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9000248&form=6&db=m Assessing delivery of lipopeptides into the cytoplasm of intact cells by a functional assay based on PKC inhibition. I. The Jurkat model. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9037258&form=6&db=m Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038375&form=6&db=m Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038873&form=6&db=m Protein kinase C-epsilon is the likely mediator of mucin exocytosis in human colonic cell lines. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9039649&form=6&db=m Involvement of protein kinase C in nerve growth factor- and K-252a-stimulated calcium uptake into PC12 cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9045318&form=6&db=m Tamoxifen for the treatment of malignancies other than breast and endometrial carcinoma. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9049854&form=6&db=m The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9052685&form=6&db=m 60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9054587&form=6&db=m Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9071558&form=6&db=m TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111198&form=6&db=m Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111205&form=6&db=m Changes in protein kinase C alpha, delta and in nuclear beta isoform expression in tumour and lung metastatic nodules induced by diethylnitrosamine in the rat. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9113106&form=6&db=m Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9131145&form=6&db=m Protein kinase C inhibition by ET-18-OCH3 and related analogs. A target for cancer chemotherapy. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9136078&form=6&db=m Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9137466&form=6&db=m Tamoxifen induces deregulation of [Ca2+] in human breast cancer cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9150279&form=6&db=m Stimulation of atrial natriuretic peptide receptor/guanylyl cyclase- A signaling pathway antagonizes the activation of protein kinase C-alpha in murine Leydig cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9154841&form=6&db=m Tumor promotion by depleting cells of protein kinase C delta. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9163671&form=6&db=m Progression of PDMT is accompanied by lack of Fas and intense expression of Bcl-2 and PKC-epsilon. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167945&form=6&db=m Protein kinase C alpha and tumorigenesis of the endocrine gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175270&form=6&db=m Sealing effects of (-)-epigallocatechin gallate on protein kinase C and protein phosphatase 2A. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9186373&form=6&db=m Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187521&form=6&db=m Mitogenic actions of peroxidase proliferators: involvement of protein kinase C and tumor necrosis factor alpha. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9192827&form=6&db=m Bryostatin-1 and IFN-gamma synergize for the expression of the inducible nitric oxide synthase gene and for nitric oxide production in murine macrophages. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9201251&form=6&db=m Increased phospholipase D activity in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202672&form=6&db=m Protein kinase C inhibits epidermal growth factor receptor phosphorylation in enterocytes. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9205496&form=6&db=m Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9206266&form=6&db=m [Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries] causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9212917&form=6&db=m Protein kinase C as a target for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9217873&form=6&db=m Endothelial dysfunction and pathogenesis of diabetic angiopathy. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223588&form=6&db=m The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223668&form=6&db=m Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9225005&form=6&db=m Posttranslational regulation of Lck and a p36-38 protein by activators of protein kinase C: differential effects of the tumor promoter, PMA, and the non-tumor-promoter, bryostatin. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9242432&form=6&db=m Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9255608&form=6&db=m Effects of transforming growth factor-beta 1 and phorbol ester on PAI-1 and PA genes in human lung cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259405&form=6&db=m Ectopic expression of platelet integrin alphaIIb beta3 in tumor cells from various species and histological origin. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261367&form=6&db=m Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9264326&form=6&db=m Differential regulation of phospholipase A2 in human leukemia cells by the etherphospholipid analogue hexadecylphosphocholine. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9269683&form=6&db=m Antisense against protein kinase C-alpha mRNA makes sense for cancer therapy? diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9272635&form=6&db=m Demyelination induced by protein kinase C-activating tumor promoters in aggregating brain cell cultures. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9278434&form=6&db=m Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288124&form=6&db=m Protein kinase C regulates macrophage tumor necrosis factor secretion: direct protein kinase C activation restores tumor necrosis factor production in endotoxin tolerance. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295340&form=6&db=m Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9307289&form=6&db=m Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9310352&form=6&db=m Linking protein kinase C to cell-cycle control. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9312025&form=6&db=m Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9312119&form=6&db=m Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9321931&form=6&db=m Role of 12-lipoxygenase and protein kinase C in modulating the activation state of the integrin alpha IIb beta 3 on human tumor cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9331096&form=6&db=m Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9336344&form=6&db=m An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9367792&form=6&db=m The old and the new in p53 functional regulation. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9374422&form=6&db=m Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9374728&form=6&db=m Stimulation of protein kinase C activity by tumor necrosis factor-alpha in bovine bronchial epithelial cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9390171&form=6&db=m Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9390172&form=6&db=m Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395784&form=6&db=m Signal transduction pathways of membrane expression of proteinase 3 (PR-3) in human endothelial cells. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395855&form=6&db=m Protein kinase C inhibitors augment tumor-necrosis-factor-induced apoptosis in normal human diploid cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9402474&form=6&db=m Effect of PMA on the integrity of the membrane skeleton and morphology of epithelial MDCK cells is dependent on the activity of amiloride-sensitive ion transporters and membrane potential. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9414406&form=6&db=m Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9440723&form=6&db=m Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9442212&form=6&db=m The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443937&form=6&db=m The involvement of novel protein kinase C isozymes in influencing sensitivity of breast cancer MCF-7 cells to tumor necrosis factor-alpha. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9454892&form=6&db=m Urinary trypsin inhibitor, a Kunitz-type protease inhibitor, modulates tumor necrosis factor-stimulated activation and translocation of protein kinase C in U937 cells. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459150&form=6&db=m Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9472709&form=6&db=m Inhibition of gap junctional intercellular communication by tumor promoters in connexin43 and connexin32-expressing liver cells: cell specificity and role of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9474241&form=6&db=m Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9482165&form=6&db=m Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9488065&form=6&db=m Characterization and modulation of transitional cell carcinoma cell lines with acquired multidrug resistance. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9495244&form=6&db=m Breast cancer cell invasiveness: correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498273&form=6&db=m Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9500474&form=6&db=m Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9533528&form=6&db=m Phase Ib trial of bryostatin 1 in patients with refractory malignancies. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547577&form=6&db=m Role of protein kinase C and phosphatases in 12(S)-HETE-induced tumor cell cytoskeletal reorganization. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547622&form=6&db=m 12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547673&form=6&db=m Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9554881&form=6&db=m Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556213&form=6&db=m Down-regulation of protein kinase C-alpha detected in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9563475&form=6&db=m Protein kinase C activation increases transepithelial transport of biologically active insulin. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9581819&form=6&db=m 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589348&form=6&db=m Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9597926&form=6&db=m Heterologous desensitization in neoplastic thyroid cells: influence of the phospholipase C signal transduction system on the thyrotropin-adenylate cyclase signal transduction system. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600337&form=6&db=m Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9607561&form=6&db=m Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9615708&form=6&db=m Expression analysis of protein kinase C isozymes and multidrug resistance associated genes in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9624687&form=6&db=m A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9645699&form=6&db=m Phospholipase D- and protein kinase C isoenzyme-dependent signal transduction pathways activated by the calcitonin receptor. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9649461&form=6&db=m Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9676858&form=6&db=m Disparity in expression of protein kinase C alpha in human glioma versus glioma-derived primary cell lines: therapeutic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9683604&form=6&db=m From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685859&form=6&db=m Inhibition by sphingosine of leukemic cell killing by human monocytes activated with interleukin-2: a possible role of protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9686926&form=6&db=m Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9699872&form=6&db=m Antiestrogen stimulated human endometrial cancer growth: laboratory and clinical considerations. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9699874&form=6&db=m Effects of LHRH-analogues on mitogenic signal transduction in cancer cells. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9701042&form=6&db=m Gender differences in nitric oxide production by alveolar macrophages in ethanol plus lipopolysaccharide-treated rats. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721628&form=6&db=m Modulation of human CACO-2 intestinal epithelial cell phenotype by protein kinase C inhibitors. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726445&form=6&db=m Cytokine expression in hepatocytes: role of oxidant stress. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726636&form=6&db=m Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9727627&form=6&db=m The role of protein glycosylation inhibitors in the prevention of metastasis and therapy of cancer. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9738664&form=6&db=m Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756852&form=6&db=m Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9756942&form=6&db=m Regulation of nucleoside transport by lipopolysaccharide, phorbol esters, and tumor necrosis factor-alpha in human B-lymphocytes. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9759380&form=6&db=m [Algal toxins, inhibitors of serine/threonine phosphatases] unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9774953&form=6&db=m Multimodality therapy: radiation and continuous concomitant cis-platinum and PKC inhibition in a cervical carcinoma model. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9784866&form=6&db=m Total synthesis and stereochemistry of cytoblastin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9811229&form=6&db=m Activation of protein kinase C by tumor necrosis factor-alpha in human non-pigmented ciliary epithelium. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815832&form=6&db=m Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816211&form=6&db=m Treatment of recurrent malignant gliomas with chronic oral high-dose tamoxifen. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9816263&form=6&db=m Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9830023&form=6&db=m Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9837921&form=6&db=m Telomerase is controlled by protein kinase Calpha in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9844914&form=6&db=m The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855018&form=6&db=m The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9865907&form=6&db=m Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9868866&form=6&db=m Increased expression of ornithine decarboxylase by gamma-ray in mouse epidermal cells: relationship with protein kinase C signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9879668&form=6&db=m The inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9916928&form=6&db=m Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920928&form=6&db=m E-selectin gene expression is induced synergistically with the coexistence of activated classic protein kinase C and signals elicited by interleukin-1beta but not tumor necrosis factor-alpha. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9925750&form=6&db=m Protein kinase calpha is an effector of hexamethylene bisacetamide-induced differentiation of Friend erythroleukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927633&form=6&db=m Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9972827&form=6&db=m Cytokine-induced production of macrophage inflammatory protein-1alpha (MIP-1alpha) in cultured human astrocytes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9988224&form=6&db=m Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10021296&form=6&db=m Protein kinase C isoform expression and activity alter paclitaxel resistance in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022281&form=6&db=m Mechanisms of quinolone phototoxicity. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022994&form=6&db=m Differential non-redox inhibitory effects of glutathione against protein kinase C isozyme family members. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027304&form=6&db=m Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027605&form=6&db=m Molecular mechanisms of proliferation in endometrial tumour cells. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10030688&form=6&db=m Two-dimensional gel electrophoresis analyses identify nucleophosmin as an estrogen regulated protein associated with acquired estrogen-independence in human breast cancer cells. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10037458&form=6&db=m Role of the protein kinase C lambda/iota isoform in nuclear factor-kappaB activation by interleukin-1beta or tumor necrosis factor-alpha: cell type specificities. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10049731&form=6&db=m The adhesion of anti-CD3-activated mouse T cells to syngeneic colon adenocarcinoma cells is differentially regulated by protein tyrosine kinase-, protein kinase C-, and cAMP-dependent pathways in the effector cell. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051543&form=6&db=m Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10068276&form=6&db=m Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10068446&form=6&db=m Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10072903&form=6&db=m Effects of Ro 31-8220 on lipopolysaccharides-induced hepatotoxicity and release of tumor necrosis factor from rat Kupffer cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10075762&form=6&db=m 28-deacetylbelamcandal, a tumor-promoting triterpenoid from Iris tectorum. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10100591&form=6&db=m The bisindolylmaleimide protein kinase C inhibitor, Ro 32-2241, reverses multidrug resistance in KB tumour cells. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188728&form=6&db=m Role of protein kinase C isoforms in locomotion of Walker 256 carcinosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10198263&form=6&db=m Interferon-gamma, bacterial lipopolysaccharide, and tumor necrosis factor-alpha induce CD11a mRNA and protein via Na+/H+ exchange and protein kinase C-dependent mechanisms in tissue macrophages. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10198352&form=6&db=m Regulation of human airway mucins by acrolein and inflammatory mediators. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10209302&form=6&db=m Effect of tumor necrosis factor-alpha on insulin signal transduction in rat adipocytes: relation to PKCbeta and zeta translocation. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10209967&form=6&db=m Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10211941&form=6&db=m The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10222061&form=6&db=m Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223183&form=6&db=m Sustained phospholipase D activation is associated with keratinocyte differentiation. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223200&form=6&db=m Lack of effect of a 60 Hz magnetic field on biomarkers of tumor promotion in the skin of SENCAR mice. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336436&form=6&db=m Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364070&form=6&db=m Differentiation of human monocytes to monocyte-derived macrophages is associated with increased lipoprotein lipase-induced tumor necrosis factor-alpha expression and production: a process involving cell surface proteoglycans and protein kinase C. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375605&form=6&db=m Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10388539&form=6&db=m Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10397270&form=6&db=m Protein kinase C delta involvement in mammary tumor cell metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402232&form=6&db=m Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402244&form=6&db=m Tamoxifen in the treatment of metastatic malignant melanoma: still a controversy? (Review). causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409245&form=6&db=m Regulation of gelatinases in human airway smooth muscle cells: mechanism of progelatinase A activation. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10424756&form=6&db=m Critical targets of protein kinase C in differentiation of tumour cells. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10438519&form=6&db=m Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446755&form=6&db=m Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454202&form=6&db=m The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10463595&form=6&db=m The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10464057&form=6&db=m Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10464065&form=6&db=m Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10469622&form=6&db=m Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470381&form=6&db=m Enzymatic rationale and preclinical support for a potent protein kinase C beta inhibitor in cancer therapy. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485491&form=6&db=m Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485493&form=6&db=m CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10504298&form=6&db=m Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506570&form=6&db=m New insights into the regulation of protein kinase C and novel phorbol ester receptors. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523655&form=6&db=m Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523713&form=6&db=m The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review). causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10529197&form=6&db=m Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10533621&form=6&db=m Tumor necrosis factor-alpha enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10548353&form=6&db=m Pharmacological inhibition of protein kinase C activity could induce apoptosis in gastric cancer cells by differential regulation of apoptosis-related genes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10550158&form=6&db=m Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer. diagnostic usage,therapeutic application,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10558913&form=6&db=m Okadaic acid stimulates the expression of vascular endothelial growth factor gene. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10569782&form=6&db=m Production of tumor necrosis factor alpha in human T lymphocytes by staphylococcal enterotoxin B correlates with toxin-induced proliferation and is regulated through protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571407&form=6&db=m The role of protein kinase Calpha in U-87 glioma invasion. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10583379&form=6&db=m Anti-proliferative effect of two novel palmitoyl-carnitine analogs, selective inhibitors of protein kinase C conventional isoenzymes. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10586115&form=6&db=m Expression of PKCeta in NIH-3T3 cells promotes production of the pro-inflammatory cytokine interleukin-6. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10589745&form=6&db=m Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597283&form=6&db=m Increased protein kinase C delta in mammary tumor cells: relationship to transformtion and metastatic progression. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600179&form=6&db=m The cancer chemopreventive agent resveratrol is incorporated into model membranes and inhibits protein kinase C alpha activity. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607885&form=6&db=m Protein kinase C-mediated phosphorylation and desensitization of human alpha(1b)-adrenoceptors. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10619187&form=6&db=m Protein kinase C mediates tumor necrosis factor-alpha-induced inhibition of obese gene expression and leptin secretion in brown adipocytes. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10628339&form=6&db=m The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640907&form=6&db=m UCN-01, a protein kinase C inhibitor, inhibits endothelial cell proliferation and angiogenic hypoxic response. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10655784&form=6&db=m [Phorbols: chemical synthesis and chemical biology] therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10675484&form=6&db=m Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676642&form=6&db=m Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690561&form=6&db=m In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10694746&form=6&db=m Relationship of gap junction formation to phosphorylation of connexin43 in mouse preimplantation embryos. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10699922&form=6&db=m Evidence against a role of general protein kinase C downregulation in skin tumor promotion. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10705481&form=6&db=m A new concise synthesis of arcyriacyanin A and its unique inhibitory activity against a panel of human cancer cell line. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708423&form=6&db=m Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737256&form=6&db=m Protein kinase C independent activation of inducible nitric oxide synthase by tumor necrosis factor-alpha in TM4 Sertoli cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10747026&form=6&db=m The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748087&form=6&db=m Direct interaction of all-trans-retinoic acid with protein kinase C (PKC). Implications for PKC signaling and cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10757128&form=6&db=m A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10761027&form=6&db=m Antisense Oligodeoxynucleotide Technology: Potential Use for the Treatment of Malignant Brain Tumors. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778982&form=6&db=m The in vivo effect of bryostatin-1 on paclitaxel-induced tumor growth, mitotic entry, and blood flow. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10783893&form=6&db=m NAK is an IkappaB kinase-activating kinase. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10804018&form=6&db=m Protein kinase C involvement in interleukin-6 production by parathyroid hormone and tumor necrosis factor-alpha in UMR-106 osteoblastic cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10805381&form=6&db=m A role for SSeCKS, a major protein kinase C substrate with tumour suppressor activity, in cytoskeletal architecture, formation of migratory processes, and cell migration during embryogenesis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10820483&form=6&db=m Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833467&form=6&db=m Clinical studies of antisense therapy in cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10835315&form=6&db=m Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10842315&form=6&db=m Identification of multiple cis-acting elements mediating the induction of prostaglandin G/H synthase-2 by phorbol ester in murine osteoblastic cells. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10852954&form=6&db=m Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854687&form=6&db=m Modification of tight junction function by protein kinase C isoforms. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10887171&form=6&db=m Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10889043&form=6&db=m Differential in vivo modifications of the HMGI(Y) nonhistone chromatin proteins modulate nucleosome and DNA interactions. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10937066&form=6&db=m Protein kinase C (PKC) isoenzymes immunohistochemistry in lymph node revealing solution-fixed, paraffin-embedded bladder tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10948142&form=6&db=m Shiga toxin-induced tumor necrosis factor alpha expression: requirement for toxin enzymatic activity and monocyte protein kinase C and protein tyrosine kinases. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952784&form=6&db=m Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10954417&form=6&db=m Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10979305&form=6&db=m [Protein kinase C as a potential target for drug development in cancer research] causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10982843&form=6&db=m SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995595&form=6&db=m Effects of tumour necrosis factor-alpha and inhibition of protein kinase C on glucose uptake in L6 myoblasts. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11003570&form=6&db=m Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11008129&form=6&db=m Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016947&form=6&db=m Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11020443&form=6&db=m Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059864&form=6&db=m In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-alpha. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11071646&form=6&db=m Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078718&form=6&db=m Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090966&form=6&db=m Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11092528&form=6&db=m The endothelin system in human glioblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104682&form=6&db=m Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11112424&form=6&db=m Overexpression of protein kinase C-eta attenuates caspase activation and tumor necrosis factor-alpha-induced cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11152962&form=6&db=m Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156956&form=6&db=m Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162606&form=6&db=m Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170310&form=6&db=m Down-regulation of particulate protein kinase Cepsilon and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11177176&form=6&db=m Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11190577&form=6&db=m Modulation of protein kinase C in antitumor treatment. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193387&form=6&db=m [Suppressive effect of protein kinase C inhibitors on tumor cell function via phosphorylation of p53 protein in mice] ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193412&form=6&db=m Synthesis and tumor-promoting activities of 12-Epi-phorbol-12,13-dibutyrate. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193580&form=6&db=m Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11205915&form=6&db=m A phase II trial of bryostatin 1 in the treatment of metastatic colorectal cancer. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11212276&form=6&db=m Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245008&form=6&db=m [An experimental study on the capability of laminin receptor antibody and protein kinase C inhibitor to inhibit tumor metastasis in vivo] causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245437&form=6&db=m Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266178&form=6&db=m The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278885&form=6&db=m Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306908&form=6&db=m Differential regulation of protein kinase C isoforms in human uterine leiomyoma. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11326671&form=6&db=m Ex vivo assays to evaluate the role of protein kinase C in tumor cells of patients with breast cancer. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11327599&form=6&db=m Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11353138&form=6&db=m Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356634&form=6&db=m Abnormal calcium and protein kinase C-epsilon signaling in hypertrophied atrial tumor myocytes (AT-1 cells). unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11358830&form=6&db=m Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11371124&form=6&db=m Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375951&form=6&db=m PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384838&form=6&db=m Platelet-derived growth factor mediated altered expression and regulation of ornithine decarboxylase in H-ras-transformed cell lines. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389098&form=6&db=m Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11399908&form=6&db=m Distribution and stimulation by gastrin-releasing peptide of protein kinase C subfamilies in insulin-secreting cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11414705&form=6&db=m A protective role of PKCepsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429284&form=6&db=m Gene trap insertion reveals two open reading frames in the mouse SSeCKS gene: the form predominantly detected in the nervous system is suppressed by the insertion while the other, specific of the testis, remains expressed. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11434681&form=6&db=m Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11435313&form=6&db=m Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11450697&form=6&db=m Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11451996&form=6&db=m High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11454719&form=6&db=m The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11457844&form=6&db=m Induction of angiogenesis by expression of soluble type II transforming growth factor-beta receptor in mouse hepatoma. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11464292&form=6&db=m CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11465069&form=6&db=m Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477572&form=6&db=m Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11478844&form=6&db=m Involvement of PKC-beta in PTH, TNF-alpha, and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH-stimulated bone resorption. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483407&form=6&db=m Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs, pathway. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11488520&form=6&db=m Activity of high-dose toremifene plus cisplatin in platinum-treated non-small-cell lung cancer: a phase II California Cancer Consortium Trial. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11488907&form=6&db=m Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507057&form=6&db=m Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11526503&form=6&db=m Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11551618&form=6&db=m Structure, expression and activation of fish ras genes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11554166&form=6&db=m Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11561682&form=6&db=m Phase II study of bryostatin 1 in patients with relapsed multiple myeloma. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11562308&form=6&db=m Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11574546&form=6&db=m The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595710&form=6&db=m Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673691&form=6&db=m Antisense therapeutics: lessons from early clinical trials. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11709714&form=6&db=m PKCeta enhances cell cycle progression, the expression of G1 cyclins and p21 in MCF-7 cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11713804&form=6&db=m Technology evaluation: ISIS-3521. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11727958&form=6&db=m Altered expression and localization of PKC eta in human breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729181&form=6&db=m Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740573&form=6&db=m Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11747987&form=6&db=m Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11762193&form=6&db=m Cloning and characterisation of the Hint homologue of the thermophile Thermus thermophilus. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772428&form=6&db=m Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779207&form=6&db=m Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795874&form=6&db=m Protein kinase Cepsilon mediates PMA-induced growth inhibition of low population density NIH 3T3 fibroblasts. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11799924&form=6&db=m Protein kinase C as a molecular target for cancer prevention by selenocompounds. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11812791&form=6&db=m Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11814414&form=6&db=m SSeCKS immunolabeling in rat primary sensory neurons. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11831653&form=6&db=m Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant cancer--an evolving story. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11831973&form=6&db=m [The effect of protein kinase C on the invasive behavior of human salivary adenoid cystic carcinoma in vitro] ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854544&form=6&db=m Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11884401&form=6&db=m Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11909764&form=6&db=m Lead induced DNA strand breaks in lymphocytes of exposed workers: role of reactive oxygen species and protein kinase C. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912160&form=6&db=m Atypical protein kinase C zeta as a target for chemosensitization of tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11948111&form=6&db=m Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956106&form=6&db=m Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11964002&form=6&db=m Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11968018&form=6&db=m Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11976687&form=6&db=m Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11983831&form=6&db=m Dietary copper affects azoxymethane-induced intestinal tumor formation and protein kinase C isozyme protein and mRNA expression in colon of rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994357&form=6&db=m Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11998565&form=6&db=m [Cancer prevention with green tea: reality and wishful thinking] causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12016268&form=6&db=m PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12030371&form=6&db=m Influence of 50 Hz electromagnetic fields in combination with a tumour promoting phorbol ester on protein kinase C and cell cycle in human cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12031982&form=6&db=m Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12048164&form=6&db=m Failure to activate caspase 3 in phorbol ester-resistant leukemia cells is associated with resistance to apoptotic cell death. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12050550&form=6&db=m Antisense oligonucleotide therapy in urology. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12083796&form=6&db=m Mitogen-induced, FAK-dependent tyrosine phosphorylation of the SSeCKS scaffolding protein. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12085962&form=6&db=m Role of eicosanoids in prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12091392&form=6&db=m Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12095674&form=6&db=m Genomic organization and chromosomal localization of the mouse protein kinase C alpha gene. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12107546&form=6&db=m A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12118374&form=6&db=m The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121973&form=6&db=m Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130632&form=6&db=m Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12133808&form=6&db=m The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development . therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12138200&form=6&db=m Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12140376&form=6&db=m Protein kinase C isoforms in normal and transformed cells of the melanocytic lineage. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12171880&form=6&db=m A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173071&form=6&db=m Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175522&form=6&db=m Gene expression profile in human prostate LNCaP cancer cells by (--) epigallocatechin-3-gallate. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12185081&form=6&db=m Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196722&form=6&db=m UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12198125&form=6&db=m Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12207561&form=6&db=m Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269829&form=6&db=m Modulation of the human protein kinase C alpha gene promoter by activator protein-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12375879&form=6&db=m Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12385783&form=6&db=m Differential expression of protein kinase C isoenzymes related to high nitric oxide synthase activity in a T lymphoma cell line. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12390803&form=6&db=m Correlation of protein kinase C activity and its subcellular distrubution with multidrug resistance in KVB200 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12407440&form=6&db=m Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12409308&form=6&db=m Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429646&form=6&db=m Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1). causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12447996&form=6&db=m Engaged urokinase receptors enhance tumor breast cell migration and invasion by upregulating alpha(v)beta5 vitronectin receptor cell surface expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12458034&form=6&db=m Specific up-regulation of CRH or AVP secretion by acetylcholine or lipopolysaccharide in inflammatory susceptible Lewis rat fetal hypothalamic cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468631&form=6&db=m Antioxidant regulation of protein kinase C in cancer prevention. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473184&form=6&db=m Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473185&form=6&db=m Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473186&form=6&db=m Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12543776&form=6&db=m Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12581572&form=6&db=m A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584183&form=6&db=m PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12635142&form=6&db=m Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12639717&form=6&db=m Survival pathways regulating the apoptosis induced by tumour necrosis factor-alpha in primary cultured bovine endothelial cells. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684678&form=6&db=m Inactive caspase 3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol ester. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12697075&form=6&db=m A protein kinase Cbeta inhibitor attenuates multidrug resistance of neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12714373&form=6&db=m Smoke and C5a induce airway epithelial intercellular adhesion molecule-1 and cell adhesion. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12729791&form=6&db=m PKCeta associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740336&form=6&db=m Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumour necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12749991&form=6&db=m Suppression of lipopolysaccharide-dependent tumor necrosis factor alpha induction in rat microglia, in which protein kinase C alpha is down-regulated. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750259&form=6&db=m Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752784&form=6&db=m Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778068&form=6&db=m Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12786795&form=6&db=m Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12787470&form=6&db=m Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794082&form=6&db=m Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794242&form=6&db=m Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein Bad and TRAIL receptors. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809530&form=6&db=m Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C). causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809676&form=6&db=m Genomic structure and promoter analysis of PKC-delta. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810551&form=6&db=m Gonadotropin-releasing hormone signaling pathways in an experimental ovarian tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810623&form=6&db=m Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839565&form=6&db=m Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12840532&form=6&db=m Protein kinase C in disease: cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12842900&form=6&db=m Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12881425&form=6&db=m Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887999&form=6&db=m Regulation of gene expression of tumour necrosis factor-alpha by protein kinase C in the rat dental follicle. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888898&form=6&db=m Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907651&form=6&db=m Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12917818&form=6&db=m Antisense strategies targeting protein kinase C: preclinical and clinical development. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920112&form=6&db=m Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920244&form=6&db=m Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939403&form=6&db=m Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941843&form=6&db=m Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954072&form=6&db=m New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12955040&form=6&db=m Combined antitumor activity of 7-hydroxystaurosporine (UCN-01) and tamoxifen against human breast carcinoma in vitro and in vivo. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970744&form=6&db=m Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500753&form=6&db=m Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506934&form=6&db=m Possible modulators of IL-8 and GRO-alpha production by granulosa cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14551511&form=6&db=m Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14559850&form=6&db=m Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14565477&form=6&db=m Antisense knockdown of PKC-alpha using LNA-oligos. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14567290&form=6&db=m siRNA agents inhibit oncogene expression and attenuate human tumor cell growth. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14593497&form=6&db=m LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597127&form=6&db=m Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-kappaB and tumor necrosis factor alpha in LLC-PK1 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602083&form=6&db=m Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14603530&form=6&db=m Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607084&form=6&db=m Divergence and complexities in DAG signaling: looking beyond PKC. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654170&form=6&db=m Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14656938&form=6&db=m Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides--implications of oxidative protein kinase C regulation to cancer prevention. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14661062&form=6&db=m Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14666709&form=6&db=m Protein kinase C eta is associated with progression of renal cell carcinoma (RCC). causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670960&form=6&db=m Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14683472&form=6&db=m Selective protein kinase C inhibitors and their applications. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14687784&form=6&db=m The role of protein kinase C-alpha (PKC-alpha) in malignancies of the gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14698564&form=6&db=m Protein kinase C delta is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14699137&form=6&db=m Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14699138&form=6&db=m Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707447&form=6&db=m Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716767&form=6&db=m A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719062&form=6&db=m Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719093&form=6&db=m The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review). causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14724218&form=6&db=m Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751526&form=6&db=m Apoptosis-modulating agents in combination with radiotherapy-current status and outlook. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751841&form=6&db=m Targeting protein kinase C-alpha (PKC-alpha) in cancer with the phosphorothioate antisense oligonucleotide aprinocarsen. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871416&form=6&db=m PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962611&form=6&db=m Ultrasound contrast agents can influence the respiratory burst activity of human neutrophil granulocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14966210&form=6&db=m Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996846&form=6&db=m The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15030953&form=6&db=m n-3 polyunsaturated fatty acids and colon cancer prevention. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15032665&form=6&db=m Protein kinase C isozymes as potential targets for anticancer therapy. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047228&form=6&db=m Phase II trial of the combination of bryostatin-1 and cisplatin in advanced or recurrent carcinoma of the cervix: a New York Gynecologic Oncology Group study. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057036&form=6&db=m The role of protein kinase C-alpha (PKC-alpha) in melanoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15095270&form=6&db=m Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15096183&form=6&db=m Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15107819&form=6&db=m Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15134488&form=6&db=m Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138589&form=6&db=m Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142358&form=6&db=m Thyrocytes isolated from autoimmune-diseased thyroids secrete soluble tumor necrosis factor-R1 that is related to their elevated protein kinase C activity. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15149857&form=6&db=m The essential role of PKCalpha in the protective effect of heat-shock pretreatment on TNFalpha-induced apoptosis in hepatic epithelial cell line. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15156560&form=6&db=m Secretions of MMP-9 by soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) mediated by protein kinase C (PKC)delta and phospholipase D (PLD) in murine macrophage. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159020&form=6&db=m Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159408&form=6&db=m Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161701&form=6&db=m Pak-1 expression increases with progression of colorectal carcinomas to metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15178807&form=6&db=m The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15180498&form=6&db=m Signaling pathways responsible for cancer cell invasion as targets for cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15180529&form=6&db=m The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217944&form=6&db=m Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15233551&form=6&db=m Gonadotropin-releasing hormone initiates multiple signaling pathways in human GH-secreting adenomas. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15251464&form=6&db=m Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study). causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289315&form=6&db=m Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs). causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313909&form=6&db=m Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15318939&form=6&db=m Osteopontin is a potential target gene in mouse mammary cancer chemoprevention by Se-methylselenocysteine. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15349752&form=6&db=m A 150-kDa glycoprotein isolated from Solanum nigrum L. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase C alpha, nuclear factor-kappa B and inducible nitric oxide in HCT-116 cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15356994&form=6&db=m Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358285&form=6&db=m Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363561&form=6&db=m Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15378488&form=6&db=m The role of c-Jun and c-Fos expression in androgen-independent prostate cancer. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386430&form=6&db=m p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15390122&form=6&db=m Gangliosides activate microglia via protein kinase C and NADPH oxidase. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458367&form=6&db=m Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459489&form=6&db=m Protein kinase C alpha expression in breast and ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494549&form=6&db=m Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15509588&form=6&db=m Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15512768&form=6&db=m Regulation of gelatinases expression by cytokines, endotoxin, and pharmacological agents in the human osteoarthritic knee. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520180&form=6&db=m Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531915&form=6&db=m Ets1 is an effector of protein kinase Calpha in cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546134&form=6&db=m Atypical protein kinase C-zeta modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555220&form=6&db=m Expression levels of protein kinase C-alpha in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563462&form=6&db=m Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579900&form=6&db=m Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585319&form=6&db=m The link between PKCalpha regulation and cellular transformation. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15586236&form=6&db=m Ectopic expression of Par-4 leads to induction of apoptosis in CNS tumor cell lines. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15601585&form=6&db=m PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15613449&form=6&db=m Novel roles of the autocrine motility factor/phosphoglucose isomerase in tumor malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15621884&form=6&db=m Matrigel invasion by the prostate cancer cell lines, PC3 and DU145, and cathepsin L+B activity. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632825&form=6&db=m Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637093&form=6&db=m Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655413&form=6&db=m Antagonists of bombesin/gastrin-releasing peptide decrease the expression of angiogenic and anti-apoptotic factors in human glioblastoma. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657361&form=6&db=m Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: real-time analysis using fluorescent ligands and proteins. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15699481&form=6&db=m Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701280&form=6&db=m Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723634&form=6&db=m Neurotransmitters and chemokines regulate tumor cell migration: potential for a new pharmacological approach to inhibit invasion and metastasis development. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15735693&form=6&db=m Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743318&form=6&db=m PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15744586&form=6&db=m Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15797241&form=6&db=m Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15798003&form=6&db=m Protein kinase C epsilon regulates tumor necrosis factor-alpha-induced stannin gene expression. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809749&form=6&db=m Different cascades in the signaling pathway of two vascular endothelial growth factor (VEGF) receptors for the VEGF-mediated murine hepatocellular carcinoma development. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15814901&form=6&db=m Involvement of protein kinase C and cyclic adenosine 3',5'-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845901&form=6&db=m PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857213&form=6&db=m Glycoprotein isolated from Solanum nigrum L. modulates the apoptotic-related signals in 12-O-tetradecanoylphorbol 13-acetate-stimulated MCF-7 cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868430&form=6&db=m Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870274&form=6&db=m The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907369&form=6&db=m Protein kinase C (PKC) family in cancer progression. diagnostic usage,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911217&form=6&db=m Effect of staurosporine on N-glycosylation and cell adhesion to fibronectin of SW480 human colorectal adenocarcinoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15914584&form=6&db=m Potassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal disease. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15922420&form=6&db=m Role of protein kinase C-alpha in superficial bladder carcinoma recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930268&form=6&db=m The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15973767&form=6&db=m Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987941&form=6&db=m Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16008942&form=6&db=m [The role of protein kinase C alpha in recurrence of superficial bladder carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16027227&form=6&db=m The repression of E2F-1 is critical for the activity of Minerval against cancer. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16041745&form=6&db=m Toward the development of new medicinal leads with selectivity for protein kinase C isozymes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044092&form=6&db=m Modulation of tumor necrosis factor-alpha and oxidative stress through protein kinase C and P42/44 mitogen-activated protein kinase in lead increases lipopolysaccharide-induced liver damage in rats. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051068&form=6&db=m Secretion of matrix metalloproteinase-9 by macrophages, in vitro, in response to Helicobacter pylori. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083718&form=6&db=m Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16101150&form=6&db=m 12-O-retinoylphorbol-13-acetate (RPA) behaves like a retinoid-derivative in binding to retinol-binding-protein: a correlation with its specific action as an incomplete tumor promoter? unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103081&form=6&db=m Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103087&form=6&db=m Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103100&form=6&db=m The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16114872&form=6&db=m Retinoic acid as a modulator of the activity of protein kinase Calpha. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16117788&form=6&db=m Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16118209&form=6&db=m Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16133798&form=6&db=m A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140950&form=6&db=m Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158048&form=6&db=m The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166314&form=6&db=m Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16169661&form=6&db=m Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184549&form=6&db=m Overexpression of PKCepsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16197574&form=6&db=m Effects of a flaxseed mixture and plant oils rich in alpha-linolenic acid on the adenoma formation in multiple intestinal neoplasia (Min) mice. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204062&form=6&db=m Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16223857&form=6&db=m Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16227394&form=6&db=m A role for PKCzeta in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16242915&form=6&db=m PKCeta is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation: C1b domain and the pseudosubstrate containing fragment target PKCeta to the Golgi and the nuclear envelope. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243773&form=6&db=m Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16291086&form=6&db=m Inhibition of human androgen-independent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-jun intracellular signalling. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16304840&form=6&db=m Expression of protein kinase C alpha in biopsies and surgical specimens of human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16318224&form=6&db=m [Euphorbiaceae diterpenes: plant toxins or promising molecules for the therapy?] unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322321&form=6&db=m Emerging role of the endothelin axis in ovarian tumor progression. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338787&form=6&db=m PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16377624&form=6&db=m Protein Kinase C {delta} Regulates Ser46 Phosphorylation of p53 Tumor Suppressor in the Apoptotic Response to DNA Damage. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391719&form=6&db=m Prostratin as a new therapeutic agent targeting HIV viral reservoirs. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407820&form=6&db=m Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16425521&form=6&db=m First-line treatment for advanced non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16434969&form=6&db=m Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456675&form=6&db=m TIS21 ( /BTG2/PC3 ) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495371&form=6&db=m Thyroid hormones increase inducible nitric oxide synthase gene expression downstream from PKC-zeta in murine tumor T lymphocytes. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508638&form=6&db=m hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513679&form=6&db=m Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517754&form=6&db=m Sensitization of IL-2 Signaling through TLR-7 Enhances B Lymphoma Cell Immunogenicity. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16523009&form=6&db=m Chronic but not acute conjugated linoleic acid treatment inhibits deoxycholic acid-induced protein kinase C and nuclear factor-kappaB activation in human colorectal cancer cells. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16572589&form=6&db=m Elucidation of stannin function using microarray analysis: implications for cell cycle control. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16581537&form=6&db=m Lead Increases Lipopolysaccharide-Induced Liver-Injury Through Tumor Necrosis Factor-alpha Overexpression by Monocytes/Macrophages: Role of Protein Kinase C and P42/44 Mitogen-Activated Protein Kinase. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16628396&form=6&db=m A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16640328&form=6&db=m Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16651413&form=6&db=m Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16670309&form=6&db=m Defective IgG2a/2b class switching in PKC alpha-/- mice. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16683077&form=6&db=m A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16683633&form=6&db=m Cloning and real-time PCR testing of 14 potential biomarkers in Eisenia fetida following cadmium exposure. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16732910&form=6&db=m [Study on the mechanism of reversing multidrug resistance of hepatocarcinoma by bromocriptine] causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740765&form=6&db=m Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778206&form=6&db=m Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785226&form=6&db=m Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797377&form=6&db=m Protein kinase C-beta as a therapeutic target in breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16798936&form=6&db=m Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818637&form=6&db=m The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849539&form=6&db=m Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16855216&form=6&db=m Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890796&form=6&db=m New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892012&form=6&db=m PKCtheta expression in gastrointestinal stromal tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940160&form=6&db=m Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943527&form=6&db=m Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16953638&form=6&db=m Comparison of the specificity of interaction of cellular and viral zinc-binding domains with 2-mercaptobenzamide thioesters. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16959960&form=6&db=m Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16968750&form=6&db=m Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17017850&form=6&db=m Mechanisms of cancer prevention by green and black tea polyphenols. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050668&form=6&db=m Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17061041&form=6&db=m Protein Kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17114487&form=6&db=m Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17127735&form=6&db=m Antitumor and normal cell protective effect of PKC412 in the athymic mouse model of ovarian cancer. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145886&form=6&db=m Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17150412&form=6&db=m The strong induction of metallothionein gene following cadmium exposure transiently affects the expression of many genes in Eisenia fetida: a trade-off mechanism? ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17158769&form=6&db=m Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17171646&form=6&db=m Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17172705&form=6&db=m Druggable signaling proteins. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17182870&form=6&db=m Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17189270&form=6&db=m alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17196728&form=6&db=m The effect of plant phenols on the expression and activity of phorbol ester-induced PKC in mouse epidermis. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17219421&form=6&db=m Protein kinase C delta enhances proliferation and survival of murine mammary cells. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17240347&form=6&db=m Development of a microscopy-based assay for protein kinase Czeta activation in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17253132&form=6&db=m Aspirin-induced apoptosis in human gastric cancer epithelial cells: relationship with protein kinase C signaling. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258375&form=6&db=m Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350960&form=6&db=m Protein kinase C delta is required for survival of cells expressing activated p21RAS. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17357479&form=6&db=m Different expressions of protein kinase C-alpha, betaI and betaII in glomeruli of diabetic nephropathy patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369850&form=6&db=m aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384583&form=6&db=m Protein kinase C and other diacylglycerol effectors in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17394491&form=6&db=m Heterogeneity of protein kinase C beta(2) expression in lymphoid malignancies. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17442483&form=6&db=m AKAP12 induces apoptotic cell death in human fibrosarcoma cells by regulating CDKI-cyclin D1 and caspase-3 activity. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459358&form=6&db=m Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17486587&form=6&db=m Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545611&form=6&db=m Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17563398&form=6&db=m Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17570678&form=6&db=m Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17577315&form=6&db=m Oxidative stress mediates CoCl(2)-induced prostate tumour cell adhesion: role of protein kinase C and p38 mitogen-activated protein kinase. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17626746&form=6&db=m [Expression and significance of aPKC-iota and E-cadherin in cholangiocarcinoma] causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17630348&form=6&db=m Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17634398&form=6&db=m Ceramide mediates inhibition of the renal epithelial sodium channel by tumor necrosis factor-alpha through protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17636410&form=6&db=m The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644309&form=6&db=m Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17654516&form=6&db=m Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17661083&form=6&db=m Protein kinase C family: On the crossroads of cell signaling in skin and tumor epithelium. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671132&form=6&db=m Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671157&form=6&db=m Enzastaurin, a protein kinase Cbeta- selective inhibitor, and its potential application as an anticancer agent in lung cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17709275&form=6&db=m Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17760843&form=6&db=m Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786031&form=6&db=m PKCeta Expression Contributes to the Resistance of Hodgkin's Lymphoma Cell Lines to Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17805485&form=6&db=m Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855511&form=6&db=m Dual Actin-bundling and Protein Kinase C-binding Activities of Fascin Regulate Carcinoma Cell Migration Downstream of Rac and Contribute to Metastasis. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875724&form=6&db=m Protein Kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17878356&form=6&db=m Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17895316&form=6&db=m The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17922632&form=6&db=m The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17927198&form=6&db=m Proteome changes in caco-2 cells treated with monascus-fermented red mold rice extract. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17938203&form=6&db=m Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17939209&form=6&db=m The expression and down stream effect of lectin like-oxidized low density lipoprotein 1 (LOX-1) in hyperglycemic state. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17951407&form=6&db=m Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952396&form=6&db=m The complex pathways of Wnt 5a in cancer progression. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956262&form=6&db=m Targeting the oncogenic protein kinase Ciota signalling pathway for the treatment of cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956267&form=6&db=m Functional PKC in vivo analysis using deficient mouse models. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956898&form=6&db=m Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17959229&form=6&db=m Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974965&form=6&db=m Protein Kinase C-{alpha} Mediated Regulation of Low-Density Lipoprotein Receptor Related Protein and Urokinase Increases Astrocytoma Invasion. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17977729&form=6&db=m Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000644&form=6&db=m Correlations of mRNA expression and in vitro chemosensitivity to enzastaurin in freshly explanted human tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006785&form=6&db=m Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006831&form=6&db=m PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18039096&form=6&db=m Von hippel-lindau disease. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18072722&form=6&db=m Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18087221&form=6&db=m Coix Seed Extract, a Commonly Used Treatment for Cancer in China, Inhibits NFkappaB and Protein Kinase C Signaling. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094021&form=6&db=m Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18098040&form=6&db=m Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18158564&form=6&db=m Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167314&form=6&db=m Protein kinase C isozymes as therapeutic targets for treatment of human cancers. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172297&form=6&db=m Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18177545&form=6&db=m Protein Kinase C Synergistically Stimulates Tumor Necrosis Factor-alpha-Induced Secretion of Urokinase-Type Plasminogen Activator in Human Dental Pulp Cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18184652&form=6&db=m Protein Kinase C{epsilon} Mediates Polymeric Fibronectin Assembly on the Surface of Blood-borne Rat Breast Cancer Cells to Promote Pulmonary Metastasis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18299806&form=6&db=m Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18309949&form=6&db=m Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18313384&form=6&db=m Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317451&form=6&db=m Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18343365&form=6&db=m Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346469&form=6&db=m Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353613&form=6&db=m Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381383&form=6&db=m Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413805&form=6&db=m Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18427549&form=6&db=m Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18429931&form=6&db=m Zinc binding site in PICK1 is dominantly located at the CPC motif of its PDZ domain. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18436431&form=6&db=m Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437080&form=6&db=m Protein kinase C: a target for therapy in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452078&form=6&db=m The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467439&form=6&db=m X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor alpha-induced apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473812&form=6&db=m Targeting protein kinase C (PKC) in physiology and cancer of the gastric cell system. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18508315&form=6&db=m PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514071&form=6&db=m The tumour suppressor RASSF1A is a novel substrate of PKC. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18538170&form=6&db=m The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577687&form=6&db=m The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18614576&form=6&db=m Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18621396&form=6&db=m PKC and MLCK-Dependent, Cytokine-Induced Rat Coronary Endothelial Dysfunction. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632643&form=6&db=m Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18650932&form=6&db=m Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18653803&form=6&db=m Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18675993&form=6&db=m The role of P38 MAPK and PKC in BLP induced TNF-alpha release, apoptosis, and NFkappaB activation in THP-1 monocyte cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691117&form=6&db=m Potential role of PKC inhibitors in the treatment of hematological malignancies. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701187&form=6&db=m Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701509&form=6&db=m Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18759374&form=6&db=m Molecular targeting of the PKC-beta inhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765998&form=6&db=m Protein kinase C beta in malignant pleural mesothelioma. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772236&form=6&db=m Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18778896&form=6&db=m Exploitation of protein kinase C: a useful target for cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18787026&form=6&db=m Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794128&form=6&db=m Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18845574&form=6&db=m Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922790&form=6&db=m Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922921&form=6&db=m Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18928283&form=6&db=m Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18981301&form=6&db=m Inhibition of protein kinase Cbeta prevents foam cell formation by reducing scavenger receptor A expression in human macrophages. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19002793&form=6&db=m Protein kinases and multidrug resistance. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19018094&form=6&db=m Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19043530&form=6&db=m Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19048456&form=6&db=m Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19086264&form=6&db=m The atypical zeta (zeta) isoform of protein kinase C regulates CD11b/CD18 activation in human neutrophils. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19096848&form=6&db=m Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101699&form=6&db=m Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107944&form=6&db=m Mechanisms involved in the down-regulation of TCR zeta chain in tumor versus peripheral blood of oral cancer patients. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19117988&form=6&db=m A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132529&form=6&db=m Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19143755&form=6&db=m Osteopontin mediates dense culture-induced proliferation and adhesion of prostate tumour cells: role of protein kinase C, p38 mitogen-activated protein kinase and calcium. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147581&form=6&db=m Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19169823&form=6&db=m Hallmarks for senescence in carcinogenesis: novel signaling players. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201988&form=6&db=m Pivotal Advance: PKC{zeta} is required for migration of macrophages. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208825&form=6&db=m Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218353&form=6&db=m TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221754&form=6&db=m Phase I study of bryostatin 1, a protein kinase C modulator, preceding cisplatin in patients with refractory non-hematologic tumors. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19223491&form=6&db=m Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19228372&form=6&db=m Protein kinase C epsilon: an oncogene and emerging tumor biomarker. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19231080&form=6&db=m Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232344&form=6&db=m PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235902&form=6&db=m Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19276374&form=6&db=m Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309400&form=6&db=m Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-kappaB in peripheral T-cell lymphomas and is associated with clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19324060&form=6&db=m Protein kinases C isozymes are differentially expressed in human breast carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19326049&form=6&db=m Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis. diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19356127&form=6&db=m Perspectives of Protein Kinase C (PKC) Inhibitors as Anti-Cancer Agents. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19417139&form=6&db=m Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19421139&form=6&db=m The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19422706&form=6&db=m Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19438240&form=6&db=m Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447039&form=6&db=m Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449873&form=6&db=m A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19459855&form=6&db=m Protein kinase Calpha-responsive polymeric carrier: its application for gene delivery into human cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19488738&form=6&db=m Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19544110&form=6&db=m Activated PKCalpha/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19545594&form=6&db=m Protein kinase C alpha-specific peptide substrate graft-type copolymer for cancer cell-specific gene regulation systems. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567682&form=6&db=m Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567915&form=6&db=m PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591825&form=6&db=m PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19617897&form=6&db=m Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19618717&form=6&db=m [Role of PKCbeta in the malignant tumors and enzastaurin, a PKCbeta inhibitor] causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19632318&form=6&db=m Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19635931&form=6&db=m Sequential Activation of Protein Kinase C Isoforms by Organic Dust is Mediated by Tumor Necrosis Factor. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19640509&form=6&db=m SLITRK1 Binds 14-3-3 and Regulates Neurite Outgrowth in a Phosphorylation-Dependent Manner. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672862&form=6&db=m Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19694904&form=6&db=m Tumor necrosis factor-alpha inhibits Schwann cell proliferation by up-regulating Src-suppressed protein kinase C substrate expression. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19710177&form=6&db=m Plasma protein kinase C (PKC){alpha} as a biomarker for the diagnosis of cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19713972&form=6&db=m Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19716839&form=6&db=m Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724676&form=6&db=m Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19738040&form=6&db=m Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756409&form=6&db=m Tumor-mediated inhibition of dendritic cell differentiation is mediated by down regulation of protein kinase C beta II expression. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19795097&form=6&db=m PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19805306&form=6&db=m aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825989&form=6&db=m H3 Histamine Receptor-Mediated Activation of Protein Kinase C{alpha} Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19855090&form=6&db=m The IGF-I Receptor Can Alter the Matrix Metalloproteinase Repertoire of Tumor Cells through Transcriptional Regulation of PKC-{alpha} causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887445&form=6&db=m Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19901015&form=6&db=m A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903468&form=6&db=m Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19935059&form=6&db=m Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19949911&form=6&db=m Expression of Protein Kinase C Family in Human Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19969380&form=6&db=m Protein kinase Calpha: disease regulator and therapeutic target. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20082445&form=6&db=m Allergy-related cytokines (IL-4 and TNF-alpha) are induced by Di(2-ethylhexyl) phthalate and attenuated by plant-originated glycoprotein (75 kDa) in HMC-1 cells. diagnostic usage,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093486&form=6&db=m Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096441&form=6&db=m Primary gastrointestinal stromal tumor of the liver with PDGFRA gene mutation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20099025&form=6&db=m Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20100803&form=6&db=m Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118114&form=6&db=m Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20138242&form=6&db=m Hepatoma-targeted gene delivery using a tumor cell-specific gene regulation system combined with a human liver cell-specific bionanocapsule. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145126&form=6&db=m Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20153162&form=6&db=m Gold nanoparticle-based colorimetric assay for cancer diagnosis. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20177147&form=6&db=m PKC-delta inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179210&form=6&db=m Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192567&form=6&db=m Curcumin: from food spice to cancer prevention. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197783&form=6&db=m Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20198332&form=6&db=m PKCepsilon induces Bcl-2 by activating CREB. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20198864&form=6&db=m [The CCNB1, HER2, and PKC silencing induced by small interfering RNA decreases a division of different human cancer cells with interfering RNA decreases a different efficiency] ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20297679&form=6&db=m [Multidrug resistance increase of tumor cells at the effect of radiation and phorbol ether depends on protein kinase C and reactive oxygen species] ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20333698&form=6&db=m Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaP(E) cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20384629&form=6&db=m Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20386467&form=6&db=m Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396929&form=6&db=m MT103 inhibits tumor growth with minimal toxicity in murine model of lung carcinoma via induction of apoptosis. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398285&form=6&db=m PKCalpha expression is a marker for breast cancer aggressiveness. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406096&form=6&db=m Dz13 induces a cytotoxic stress response with upregulation of E2F1 in tumor cells metastasizing to or from bone. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406951&form=6&db=m Epithelial-to-Mesenchymal Transition and Oncogenic Ras Expression in Resistance to the Protein Kinase C{beta} Inhibitor Enzastaurin in Colon Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20407013&form=6&db=m Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20460505&form=6&db=m The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471435&form=6&db=m Regulation of tumor suppressor PDCD4 by novel protein kinase C isoforms. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20494415&form=6&db=m Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501645&form=6&db=m Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20516369&form=6&db=m Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592962&form=6&db=m Regulation of Transgene Expression in Tumor Cells by Exploiting Endogenous Intracellular Signals. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20619088&form=6&db=m [The role of PKC to TNF-alpha induced beta-1, 4-galactosyltransferase-I expression in endothelial cells]. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20628400&form=6&db=m Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664941&form=6&db=m Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673527&form=6&db=m [The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20692938&form=6&db=m Effect of the dihydropyridine dexniguldipine on the epidermal growth factor-stimulated proliferation of human lung cancer cell lines. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20707806&form=6&db=m Phase I dose escalation and pharmacokinetic study of oral enzastaurin (LY317615) in advanced solid tumors. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20713153&form=6&db=m High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716167&form=6&db=m Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716168&form=6&db=m DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20724829&form=6&db=m Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition! causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20727927&form=6&db=m Tumor therapy by gene regulation system responding to cellular signal. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20798497&form=6&db=m GH3B6 pituitary tumor cell proliferation is mediated by PKCalpha and PKCepsilon via ERK 1/2-dependent pathway. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20858866&form=6&db=m Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876745&form=6&db=m Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20936324&form=6&db=m Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium study. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20948918&form=6&db=m Clinicopathological and immunohistochemical features of gastointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20964459&form=6&db=m Current approaches to the management of diabetic retinopathy and diabetic macular oedema. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069811&form=6&db=m Tumor-induced endothelial cell apoptosis: roles of NAD(P)H oxidase-derived reactive oxygen species. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21132404&form=6&db=m (1)H, (13)C and (15)N NMR assignments of the C1A and C1B subdomains of PKC-delta. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21136834&form=6&db=m Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21155880&form=6&db=m Aberrant expression of epidermal growth factor receptor and its interaction with protein kinase C ? in inflammation associated neoplastic transformation of human esophageal epithelium in high risk populations. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21175182&form=6&db=m Fluorescent-responsive synthetic C1b domains of protein kinase C? as reporters of specific high-affinity ligand binding. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21224724&form=6&db=m Transgenic overexpression of PKC? in the mouse prostate induces preneoplastic lesions. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21252239&form=6&db=m Differential Regulation of Gene Expression by Protein Kinase C Isozymes as Determined by Genome-wide Expression Analysis. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268127&form=6&db=m Upregulation of the EP1 receptor for prostaglandin E(2) promotes skin tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21281788&form=6&db=m Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21315177&form=6&db=m A novel PKC-? inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21331591&form=6&db=m Staurosporine induces megakaryocytic differentiation through the upregulation of JAK/Stat3 signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21335545&form=6&db=m Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340822&form=6&db=m Compartmentalized protein kinase C activation in ovarian carcinoma cells. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21432144&form=6&db=m INK4 Family -A promising target for 'gene-regulating chemoprevention' and 'molecular-targeting prevention' of cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21470133&form=6&db=m The Pros and Cons of Targeting Protein Kinase c (PKC) in the Management of Cancer Patients. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480396&form=6&db=m Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C ? with Stat3 involve integration with Erk1/2. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21499124&form=6&db=m EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21506107&form=6&db=m Tumor-induced endothelial cell apoptosis: roles of NAD(P)H oxidase-derived reactive oxygen species. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533346&form=6&db=m Expression of the invasive phenotype by MCF-7 human breast cancer cells transfected to overexpress protein kinase C-alpha or the erbB2 proto-oncogene. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21534929&form=6&db=m Fine tuning of protein kinase C (PKC) isoforms in cancer: shortening the distance from the laboratory to the bedside. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552864&form=6&db=m Cooperative inhibitory effect of n,n,n-trimethylsphingosine and sphingosine-1-phosphate, co-incorporated in liposomes, on b16 melanoma cell metastasis - cell-membrane signaling as a target in cancer-therapy .4. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556534&form=6&db=m The phosphorylation connection to cancer (review). causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556652&form=6&db=m Distinct signaling mediates chloride secretion induced by tumor promoter bile-salts and phorbol esters in human colonic cells. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566983&form=6&db=m Circumvention of multidrug-resistance in murine fibrosarcoma and colon-carcinoma cells by treatment with the alpha-adrenoceptor antagonist furobenzazepine. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21606156&form=6&db=m Targeting protein kinase C by Enzastaurin restrains proliferation and secretion in human pancreatic endocrine tumors. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21607397&form=6&db=m Comparative-studies on the anti-invasive effects of retinoic Acid and staurosporine. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21625473&form=6&db=m A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21685034&form=6&db=m Gastrointestinal stromal tumor markers in cutaneous melanomas: relationship to prognostic factors and outcome. diagnostic usage,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21712053&form=6&db=m Protein kinase C ? regulates nuclear pri-microRNA 15a release as part of endothelin signaling. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21720730&form=6&db=m Protein kinase C? suppresses the expression of STC1 in MDA-MB-231 breast cancer cells. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21795525&form=6&db=m Tumor necrosis factor-alpha down regulates sodium current in skeletal muscle by protein kinase C activation: involvement in critical illness polyneuromyopathy. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21803068&form=6&db=m Baicalein inhibits the migration and invasive properties of human hepatoma cells. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21805047&form=6&db=m Proteomic analysis identifies nuclear protein effectors in PKC-delta signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21836495&form=6&db=m KIT-Negative Gastrointestinal Stromal Tumor of the Abdominal Soft Tissue: A Clinicopathologic and Genetic Study of 10 Cases. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21859831&form=6&db=m Protein Kinase C {zeta} is a positive modulator of canonical Wnt signaling pathway in tumoral colon cell lines. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21870234&form=6&db=m Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21876792&form=6&db=m Protein kinase C and toll-like receptor signaling. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895402&form=6&db=m Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21903207&form=6&db=m Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905203&form=6&db=m Protein kinase C in Wnt signaling: Implications in cancer initiation and progression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955404&form=6&db=m The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21996750&form=6&db=m Proteins kinase C? is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22069553&form=6&db=m The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22095874&form=6&db=m Contribution of individual PKC isoforms to breast cancer progression. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22102721&form=6&db=m A novel pathway responsible for lipopolysaccharide-induced translational regulation of TNF-? and IL-6 expression involves protein kinase C and fascin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22144112&form=6&db=m Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-? signaling and contributes to neuronal death. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160590&form=6&db=m Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228765&form=6&db=m Protein Kinase D regulates RhoA activity via Rhotekin phosphorylation. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240482&form=6&db=m RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the ?-Catenin Destruction Complex. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22261918&form=6&db=m Inhibition of Protein Kinase C ?(2) Prevents Tumor Necrosis Factor-?-Induced Apoptosis and Oxidative Stress in Endothelial Cells: The Role of NADPH Oxidase Subunits. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22301880&form=6&db=m Development of diacyltetrol lipids as activators for the C1 domain of protein kinase C. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349825&form=6&db=m Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22381066&form=6&db=m The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22384062&form=6&db=m Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22410117&form=6&db=m Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC ?-independent mechanism. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22414757&form=6&db=m Alkyl cinnamates as regulator for the C1 domain of protein kinase C isoforms. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22429968&form=6&db=m MicroRNA 15a, inversely correlated to PKC?, is a potential marker to differentiate between benign and malignant renal tumors in biopsy and urine samples. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22430047&form=6&db=m J-4: a novel and typical preclinical anticancer drug targeting protein kinase C ?. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442164&form=6&db=m Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22505472&form=6&db=m Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22512531&form=6&db=m Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C Pathway. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22543197&form=6&db=m Thermostable direct hemolysin diminishes tyrosine phosphorylation of epidermal growth factor receptor through protein kinase C dependent mechanism. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22566604&form=6&db=m Inhibition of the mTORC2 and chaperone pathways to treat leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22580516&form=6&db=m Chemical structure of phenothiazines and their biological activity. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22684366&form=6&db=m Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773839&form=6&db=m Protein Kinase C? (PKC?) Regulates p53 Localization and Melanoma Cell Survival Downstream of Integrin ?v in Three-dimensional Collagen and in Vivo. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22799301&form=6&db=m Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22855655&form=6&db=m A Case of KIT-Negative Extra-Gastrointestinal Stromal Tumor of the Lesser Omentum. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22861150&form=6&db=m Effects of ortho substituent groups of protocatechualdehyde derivatives on binding to the c1 domain of novel protein kinase C. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22868505&form=6&db=m Localization of PKC? in Cell Membranes as a Predictor for Breast Cancer Response to Treatment. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886693&form=6&db=m Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22892130&form=6&db=m Novel regulation of protein kinase C-?. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993348&form=6&db=m High nuclear protein kinase C?II expression is a marker of disease recurrence in oral squamous cell carcinoma. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23023376&form=6&db=m p62 binding to protein kinase C ? regulates tumor necrosis factor ?-induced apoptotic pathway in endothelial cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23068102&form=6&db=m Carnitine sensitizes TRAIL-resistant cancer cells to TRAIL-induced apoptotic cell death through the up-regulation of Bax. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23086478&form=6&db=m NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-? and reactive oxygen species. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23111456&form=6&db=m Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23197040&form=6&db=m Protein kinase C, an elusive therapeutic target? causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376641&form=6&db=m Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23400472&form=6&db=m Maximizing the benefits of off-target kinase inhibitor activity. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23402259&form=6&db=m Quantitative Study of the Interactome of PKC? Involved in the EGF-induced Tumor Cell Chemotaxis. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520519&form=6&db=m Protein kinase C delta negatively modulates canonical wnt pathway and cell proliferation in colon tumor cell lines. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536578&form=6&db=m Nanog expression is negatively regulated by Protein Kinase C activities in human cancer cell lines. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23634843&form=6&db=m Extranuclear ER? is associated with regression of T47D PKC?-overexpressing, tamoxifen-resistant breast cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23695799&form=6&db=m Modulation of Pancreatic Tumor Potential by Overexpression of Protein Kinase C ?1. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23752190&form=6&db=m Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23826267&form=6&db=m Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23843797&form=6&db=m Protein Kinase C ? Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23890134&form=6&db=m aPKC?/? is a beneficial prognostic marker for pancreatic neoplasms. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23893384&form=6&db=m RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23897302&form=6&db=m Peptide-based ligand screening and functional analysis of protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23995654&form=6&db=m Regulation of the expression and activity of glucose and lactic Acid metabolism-related genes by protein kinase C in skeletal muscle cells. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24072773&form=6&db=m Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24130723&form=6&db=m Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24183651&form=6&db=m EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24212628&form=6&db=m Protein kinase C: an attractive target for cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24212825&form=6&db=m Regulation of autophagy by kinases. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24231509&form=6&db=m Atypical protein kinase C? as a human oncogene and therapeutic target. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24239713&form=6&db=m Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-? secretion through protein kinase C and I?B kinase 2 signaling. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24254684&form=6&db=m Actions of a tumor-promoting phorbol ester in a cloned rat pituitary cell : Potential involvement of changes in Ca(2+) metabolism. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260357&form=6&db=m Global phosphotyrosine proteomics identifies PKC? as a marker of responsiveness to Src inhibition in colorectal cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24316392&form=6&db=m A new PKC?/?/TBX3/E-cadherin pathway is involved in PLC?-regulated invasion and migration in human bladder cancer cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24318287&form=6&db=m Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24336328&form=6&db=m Protein kinase C and cancer: what we know and what we do not. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486483&form=6&db=m Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528676&form=6&db=m Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24574001&form=6&db=m Ellagic acid inhibits PKC signaling by improving antioxidant defense system in murine T cell lymphoma. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24599099&form=6&db=m Building Bridges toward Invasion: Tumor Promoter Treatment Induces a Novel Protein Kinase C-Dependent Phenotype in MCF10A Mammary Cell Acini. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603690&form=6&db=m Association of PKC? Expression with Clinicopathological Characteristics of Breast Cancer. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677503&form=6&db=m Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727247&form=6&db=m The Multifunctional Protein Kinase C-? in Cancer Development and Progression. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753817&form=6&db=m 12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24777910&form=6&db=m Charge density influences C1 domain ligand affinity and membrane interactions. therapeutic application,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792822&form=6&db=m Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24795864&form=6&db=m Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814288&form=6&db=m FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24879583&form=6&db=m Antioxidant and antiproliferative activities of methanolic extract from a neglected agricultural product: corn cobs. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24906106&form=6&db=m Molecular systems pharmacology: isoelectric focusing signature of protein kinase C? provides an integrated measure of its modulation in response to ligands. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24910994&form=6&db=m Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24936745&form=6&db=m Membrane Interaction and Protein Kinase C-C1 Domain Binding Properties of 4-Hydroxy-3-(hydroxymethyl) Phenyl Ester Analogues. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24960060&form=6&db=m Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24990612&form=6&db=m PKC? and PKM? are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25001530&form=6&db=m Signalling of apoptin. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25015091&form=6&db=m A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKC? and E-cadherin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25052149&form=6&db=m Elevation of PRKCDBP, a novel transcriptional target of TNF-?, and its downregulation by infliximab in patients with ulcerative colitis. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25103979&form=6&db=m Spinal NMDA receptor activation constrains inactivity-induced phrenic motor facilitation in Charles River Sprague-Dawley rats. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109829&form=6&db=m Screening for protein kinase C ligands using fluorescence resonance energy transfer. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118327&form=6&db=m Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF? in glioblastoma. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118570&form=6&db=m HOIL-1L functions as the PKC? ubiquitin ligase to promote lung tumor growth. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120645&form=6&db=m Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C ?/?, E-cadherin, ?-catenin and basement membrane component. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152584&form=6&db=m Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25190464&form=6&db=m Synthesis and protein kinase C (PKC)-C1 domain binding properties of diacyltetrol based anionic lipids. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25276484&form=6&db=m What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is ?2-Adrenergic Receptor Gene Polymorphism Important? causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301738&form=6&db=m Regulation of the viability of Nf1 deficient cells by PKC isoforms. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25363829&form=6&db=m Protein Kinase C Inhibitor, GF109203X Attenuates Osteoclastogenesis, Bone Resorption and RANKL-Induced NF-?B and NFAT Activity. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25379403&form=6&db=m Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25399557&form=6&db=m Tuning the signalling output of protein kinase C. diagnostic usage,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25420887&form=6&db=m The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483185&form=6&db=m Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25486357&form=6&db=m Protein kinase C ? inhibition by enzastaurin leads to mitotic missegregation and preferential cytotoxicity toward colorectal cancer cells with chromosomal instability (CIN). causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25619690&form=6&db=m Cancer-Associated Protein Kinase C Mutations Reveal Kinase's Role as Tumor Suppressor. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25655913&form=6&db=m Protein kinase C isozymes are tumor suppressors. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663494&form=6&db=m Genetic variations in the PRKCG gene and osteosarcoma risk in a Chinese population: a case-control study. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693686&form=6&db=m Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25710634&form=6&db=m Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogues for Analysis with Rotational Echo Double Resonance NMR Spectroscopy. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25728678&form=6&db=m CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750277&form=6&db=m Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25754990&form=6&db=m Inhibition of PKC-induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25756394&form=6&db=m TGF?-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25828882&form=6&db=m Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25874946&form=6&db=m Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904380&form=6&db=m Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26021525&form=6&db=m Downregulation of BDNF Expression by PKC and by TNF-? in Human Endothelial Cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26023164&form=6&db=m PKC? Is an Essential Mediator of Prostate Cancer Bone Metastasis. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26056003&form=6&db=m PKC? promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076811&form=6&db=m Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26260115&form=6&db=m SLC44A1-PRKCA fusion in papillary and rosette-forming glioneuronal tumors. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26269582&form=6&db=m Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26279297&form=6&db=m PKCiota promotes ovarian tumor progression through deregulation of cyclin E. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26284819&form=6&db=m Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1? Accumulation in Cancer Cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26292580&form=6&db=m Structural insights into the interactions of phorbol ester and bryostatin complexed with protein kinase C: a comparative molecular dynamics simulation study. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26311153&form=6&db=m Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26431317&form=6&db=m Synergistic Gene Expression Signature Observed in TK6 Cells upon Co-Exposure to UVC-Irradiation and Protein Kinase C-Activating Tumor Promoters. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26459812&form=6&db=m Current status and future directions of anti-angiogenic therapy for gliomas. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26466675&form=6&db=m Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484144&form=6&db=m The role of protein kinase-C theta in control of epithelial to mesenchymal transition and cancer stem cell formation. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484266&form=6&db=m Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26644690&form=6&db=m Protection mechanism of early hyperbaric oxygen therapy in rats with permanent cerebral ischemia. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26676968&form=6&db=m Pigment-Synthesizing Melanocytic Neoplasm With Protein Kinase C Alpha (PRKCA) Fusion. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26859836&form=6&db=m Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884258&form=6&db=m Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911897&form=6&db=m Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26918447&form=6&db=m PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26989024&form=6&db=m Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27037060&form=6&db=m PKC? inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27122053&form=6&db=m Apoptotic Effects of Rotundic Acid on Human Esophagus and Lung Cancer Cells. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27330189&form=6&db=m MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27351203&form=6&db=m miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27436807&form=6&db=m Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27453417&form=6&db=m Receptor for activated protein kinase C 1 suppresses gastric tumor progression through nuclear factor-kB pathway. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27457194&form=6&db=m Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481515&form=6&db=m PKC iota promotes cellular proliferation by accelerated G1/S transition via interaction with CDK7 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27490967&form=6&db=m Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554601&form=6&db=m 14-3-3? promotes lung cancer cell invasion by increasing the Snail protein expression through atypical protein kinase C (aPKC)/NF-?B signaling. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27578797&form=6&db=m IKK? inhibits PKC to promote Fascin-dependent actin bundling. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590822&form=6&db=m Lack of overt genome reduction in the bryostatin-producing bryozoan symbiont, "Candidatus Endobugula sertula". causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602113&form=6&db=m Effect of MUC1/?-catenin interaction on the tumorigenic capacity of pancreatic CD133(+) cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27621580&form=6&db=m Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27816562&form=6&db=m Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28045490&form=6&db=m An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053624&form=6&db=m Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056869&form=6&db=m Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28085924&form=6&db=m Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28092804&form=6&db=m Enhancement of NK cell-mediated lysis of non-small lung cancer cells by nPKC activator, ingenol 3,20 dibenzoate. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28112438&form=6&db=m Protein kinase C in cancer: The top five unanswered questions. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28232750&form=6&db=m Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28242340&form=6&db=m Effect of ?-linolenic acid-rich diacylglycerol oil on protein kinase C activation in the rat digestive tract and lingual mucosa. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28283201&form=6&db=m Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28367652&form=6&db=m Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28476658&form=6&db=m Protein kinase C as a tumor suppressor. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28571764&form=6&db=m Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28590507&form=6&db=m Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28629334&form=6&db=m Protein kinase C-? (PKC?) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28631559&form=6&db=m PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28671468&form=6&db=m Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28756980&form=6&db=m PKC-? attenuates the cancer stem cell among squamous cell carcinoma cells through down-regulating p63. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28811127&form=6&db=m Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28928894&form=6&db=m MZF-1/Elk-1/PKC? is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039083&form=6&db=m Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048616&form=6&db=m The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29069410&form=6&db=m Protein kinase C in fungi-more than just cell wall integrity. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29129688&form=6&db=m Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29216867&form=6&db=m Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29219195&form=6&db=m Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348560&form=6&db=m Discovery of a small-molecule protein kinase C?-selective activator with promising application in colon cancer therapy. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29445214&form=6&db=m RACK1 is indispensable for porcine reproductive and respiratory syndrome virus replication and NF-?B activation in Marc-145 cells. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29456240&form=6&db=m Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29476136&form=6&db=m A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29491746&form=6&db=m Profiling the interactome of protein kinase C ? by proteomics and bioinformatics. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29517836&form=6&db=m Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29551772&form=6&db=m Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29610452&form=6&db=m Baicalin Inhibits Human Cervical Cancer Cells by Suppressing Protein Kinase C/Signal Transducer and Activator of Transcription (PKC/STAT3) Signaling Pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29688013&form=6&db=m Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775743&form=6&db=m Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29915258&form=6&db=m A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29927112&form=6&db=m Generating Conformation-Specific Polyclonal and Monoclonal Anti-Protein Kinase C Antibodies and Anti-Active State Specific PKC Antibodies. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961393&form=6&db=m Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034696&form=6&db=m Turn up the cellular power generator with vitamin E analogue formulation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30185893&form=6&db=m A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30194076&form=6&db=m Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30209539&form=6&db=m Crosstalk of protein kinase C ? with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30352123&form=6&db=m GLUT12 expression and regulation in murine small intestine and human Caco-2 cells. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396949&form=6&db=m Atypical Protein Kinase C ?/? Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30516514&form=6&db=m MEDICAL BASIS OF DIABETIC NEUROPATHY FORMATION (REVIEW). causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30552022&form=6&db=m Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30562553&form=6&db=m Differential effects of protein kinase C-eta on apoptosis versus senescence. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30668399&form=6&db=m The protective effects of the native flavanone flavanomarein on neuronal cells damaged by 6-OHDA. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30676176&form=6&db=m Differential radio-adaptive responses in BALB/c and C57BL/6 mice: pivotal role of calcium and nitric oxide signalling. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30739223&form=6&db=m Phospho-substrate profiling of Epac-dependent protein kinase C activity. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30771901&form=6&db=m Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30904392&form=6&db=m Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30923343&form=6&db=m Distinctive requirement of PKC? in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30962803&form=6&db=m RACK1 Acts as a Potential Tumor Promoter in Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988374&form=6&db=m Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31106579&form=6&db=m Effect of Prenatal Waterpipe Tobacco Smoke Exposure on Cardiac Biomarkers in Adult Offspring Rats. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31197641&form=6&db=m Klotho Ameliorates Cellular Inflammation via Suppression of Cytokine Release and Upregulation of miR-29a in the PBMCs of Diagnosed Alzheimer's Disease Patients. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31412817&form=6&db=m Clinical significance of atypical protein kinase C (PKC? and PKC?) and its relationship with yes-associated protein in lung adenocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516713&form=6&db=m Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31524271&form=6&db=m Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31568643&form=6&db=m Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31570472&form=6&db=m Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31572289&form=6&db=m FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31626552&form=6&db=m En Route to D-Ring Inverted Phorbol Esters. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31689616&form=6&db=m hsa_circ_0092306 Targeting miR-197-3p Promotes Gastric Cancer Development by Regulating PRKCB in MKN-45 Cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775562&form=6&db=m Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931659&form=6&db=m Autophagy drives fibroblast senescence through MTORC2 regulation. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934613&form=6&db=m LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31938102&form=6&db=m PKC? reveals a tumor promoter function by promoting cell proliferation and migration in somatotropinomas. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32029634&form=6&db=m Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32065092&form=6&db=m Potential Biomarkers in Diabetic Retinopathy. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32100928&form=6&db=m cPLA2? reversibly regulates different subsets of cancer stem cells transformation in cervical cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32128390&form=6&db=m Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139146&form=6&db=m Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve. diagnostic usage,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175276&form=6&db=m The Atypical Protein Kinase C Small Molecule Inhibitor ?-Stat, and Its Effects on Invasion Through Decreases in PKC-? Protein Expression. causal interaction,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32194726&form=6&db=m MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32357622&form=6&db=m Hybridization studies of cultured human pituitary prl and gh producing adenoma cells: Effects of thyrotropin-releasing hormone, somatostatin, and phorbol ester. diagnostic usage,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32456148&form=6&db=m Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32600444&form=6&db=m PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742373&form=6&db=m Treatment with Pluchea indica (L.) Less. leaf ethanol extract alleviates liver injury in multiple low-dose streptozotocin-induced diabetic BALB/c mice. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32829709&form=6&db=m Imaging the rapid yet transient accumulation of regulatory lipids, lipid kinases, and protein kinases during membrane fusion, at sites of exocytosis of MMP-9 in MCF-7 cells. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865619&form=6&db=m Protein Kinase C Alpha (PKC?) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RAR?) activation in mammary cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32934684&form=6&db=m Combined culture experiment of mouse bone marrow mesenchymal stem cells and bioceramic scaffolds. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32985670&form=6&db=m Epithelial Barrier Properties of the 16HBE14o- Human Bronchial Epithelial Cell Culture Model. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32994205&form=6&db=m PKC epsilon is required for KRAS-driven lung tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33039823&form=6&db=m A cancer-associated, genome protective programme engaging PKC?. causal interaction,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33066446&form=6&db=m 12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-?/PKD/ERK Signaling Pathway. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33140671&form=6&db=m Tetrandrine Attenuates Cartilage Degeneration, Osteoclast Proliferation, and Macrophage Transformation through Inhibiting P65 Phosphorylation in Ovariectomy-induced Osteoporosis. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33177705&form=6&db=m Equivocal, explicit and emergent actions of PKC isoforms in cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33218172&form=6&db=m Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I. therapeutic application,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33318039&form=6&db=m Unconventional Secretion of PKC? Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33374361&form=6&db=m Cell Death Signaling Pathway Induced by Cholix Toxin, a Cytotoxin and eEF2 ADP-Ribosyltransferase Produced by Vibrio cholerae. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33420238&form=6&db=m Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33456518&form=6&db=m Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-?B translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33466486&form=6&db=m Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33490232&form=6&db=m Unravelling Structure, Localization, and Genetic Crosstalk of KLF3 in Human Breast Cancer. ongoing research,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33502516&form=6&db=m PHLPPing the balance: restoration of protein kinase C in cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33507464&form=6&db=m Serum levels of FAK and some of its effectors in adult AML: correlation with prognostic factors and survival. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524008&form=6&db=m Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33525953&form=6&db=m Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33562506&form=6&db=m The Emerging Function of PKCtheta in Cancer. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576006&form=6&db=m Crosstalk between miR-203 and PKC? regulates breast cancer stem cell markers. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577665&form=6&db=m Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities. ongoing research,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617877&form=6&db=m Protein kinase C fusion proteins are paradoxically loss of function in cancer. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660148&form=6&db=m Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33723318&form=6&db=m All-trans retinoic acid and protein kinase C ?/?1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33818747&form=6&db=m Mechanistic insight on the role of leukotriene receptors in ischemic-reperfusion injury. unassigned - 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33890761&form=6&db=m Protein Kinase C ?-Responsive Gene Carrier for Cancer-Specific Transgene Expression and Cancer Therapy. therapeutic application,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33917514&form=6&db=m Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition. therapeutic application,unassigned 2,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34131018&form=6&db=m Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195807&form=6&db=m Prostasin regulates PD-L1 expression in human lung cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34222094&form=6&db=m Inflammatory biomarkers as a part of diagnosis in diabetic peripheral neuropathy. causal interaction,unassigned 1,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34338277&form=6&db=m Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370642&form=6&db=m Comprehensive Account on the Synthesis of (-)-Balanol and its Analogues. causal interaction,unassigned 3,0 2.7.11.13 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34375670&form=6&db=m PKC? regulates the expression of PDL1 through multiple pathways to modulate immune suppression of pancreatic cancer cells. ongoing research,unassigned 4,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312276&form=6&db=m How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. causal interaction,unassigned 4,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11712865&form=6&db=m Protein kinase C isoforms as therapeutic targets in nervous system disease states. therapeutic application,unassigned 4,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633700&form=6&db=m Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20006676&form=6&db=m Protein kinase C deficiency-induced alcohol insensitivity and underlying cellular targets in Drosophila. causal interaction,unassigned 3,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23436724&form=6&db=m Protein interacting with C kinase and neurological disorders. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904794&form=6&db=m Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27490967&form=6&db=m Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28482641&form=6&db=m Bryostatin Effects on Cognitive Function and PKC? in Alzheimer's Disease Phase IIa and Expanded Access Trials. unassigned - 2.7.11.13 Nervous System Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719093&form=6&db=m The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review). causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8922669&form=6&db=m Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.7.11.13 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14613966&form=6&db=m Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21376163&form=6&db=m Protein kinase C?2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway. unassigned - 2.7.11.13 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474670&form=6&db=m Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1393564&form=6&db=m Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury. causal interaction,unassigned 3,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8742791&form=6&db=m The association of neuropathic pain, morphine tolerance and dependence, and the translocation of protein kinase C. unassigned - 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9323205&form=6&db=m Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9366465&form=6&db=m Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9952097&form=6&db=m Spinal mechanisms of acute and persistent pain. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375678&form=6&db=m The types of neuron which contain protein kinase C gamma in rat spinal cord. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10393889&form=6&db=m Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. causal interaction,unassigned 4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10393891&form=6&db=m Distinct neurochemical features of acute and persistent pain. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10428394&form=6&db=m Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma. therapeutic application,unassigned 4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576741&form=6&db=m Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats. ongoing research,unassigned 2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667440&form=6&db=m Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15099668&form=6&db=m Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in mice. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456833&form=6&db=m Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16836642&form=6&db=m Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons. causal interaction,unassigned 4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17157774&form=6&db=m TrkA and PKC-epsilon in thermal burn-induced mechanical hyperalgesia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17349994&form=6&db=m mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption. ongoing research,unassigned 1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17586495&form=6&db=m Pain behaviors after spinal cord contusion injury in two commonly used mouse strains. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18387748&form=6&db=m Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18835424&form=6&db=m Neuropathic pain and temporal expression of preprodynorphin, protein kinase C and N-methyl-D-aspartate receptor subunits after spinal cord injury. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854053&form=6&db=m Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury. unassigned - 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471878&form=6&db=m Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca(2+) channels. ongoing research,unassigned 2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21239826&form=6&db=m Neurobiological mechanisms of pain in sickle cell disease. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21291534&form=6&db=m Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22221687&form=6&db=m Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22284620&form=6&db=m Identification of differentially expressed proteins in the spinal cord of neuropathic pain models with PKCgamma silence by proteomic analysis. unassigned - 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22954912&form=6&db=m [Effect of intrathecal sufentanil and protein kinase C inhibitor on pain threshold and the expression of NMDA receptor/ CGRP in spinal dorsal horn in rats with neuropathic pain]. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24554509&form=6&db=m Animal models of diabetic neuropathic pain. causal interaction,unassigned 4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26143011&form=6&db=m The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKC?. causal interaction,unassigned 4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26270583&form=6&db=m Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26750151&form=6&db=m Activation of medullary dorsal horn ? isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27302958&form=6&db=m Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction. therapeutic application,unassigned 4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27380044&form=6&db=m Involvement of Spinal PKM? Expression and Phosphorylation in Remifentanil-Induced Long-Term Hyperalgesia in Rats. therapeutic application,unassigned 1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27458019&form=6&db=m Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27490967&form=6&db=m Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30180777&form=6&db=m Mechanisms for therapeutic effect of bulleyaconitine A on chronic pain. therapeutic application,unassigned 1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30344660&form=6&db=m Influence of intrathecal injection with dexmedetomidine on the behavioral ability and analgesic effects on rats with neuropathic pain and expression of protein kinase C in the spinal dorsal horn. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32352640&form=6&db=m A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain. therapeutic application,unassigned 3,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865105&form=6&db=m Pain modulation effect on motor cortex after optogenetic stimulation in shPKC? knockdown dorsal root ganglion-compressed Sprague-Dawley rat model. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014214&form=6&db=m Effect of PKC/NF-?B on the Regulation of P2X3 Receptor in Dorsal Root Ganglion in Rats with Sciatic Nerve Injury. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33207243&form=6&db=m FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors. causal interaction,unassigned 2,0 2.7.11.13 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055342&form=6&db=m Mechanisms of pain in sickle cell disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Neuralgia, Postherpetic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23438341&form=6&db=m The Safety and Efficacy of KAI-1678- An Inhibitor of Epsilon Protein Kinase C (?PKC)-Versus Lidocaine and Placebo for the Treatment of Postherpetic Neuralgia: A Crossover Study Design. therapeutic application,unassigned 4,0 2.7.11.13 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12673781&form=6&db=m Polyol pathway and protein kinase C activity of rat Schwannoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743318&form=6&db=m PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21400668&form=6&db=m DOG1 Utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.11.13 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1544425&form=6&db=m Characterization and differential expression of protein kinase C isoforms in PC12 cells. Differentiation parallels an increase in PKC beta II. causal interaction,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1281743&form=6&db=m Differential effects of the protein kinase C inhibitors H7 and calphostin C on the cell cycle of neuroblastoma cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1293966&form=6&db=m Interaction between phosphatidylserine biosynthesis and protein kinase C activation in neuroblastoma NB2a cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312952&form=6&db=m Intracellular delivery of protein kinase C-alpha or -epsilon isoform-specific antibodies promotes acquisition of a morphologically differentiated phenotype in neuroblastoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331757&form=6&db=m Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332804&form=6&db=m Insulin-like growth factor I modulates voltage-dependent Ca2+ channels in neuronal cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335089&form=6&db=m Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1378489&form=6&db=m Activation of protein kinase C in permeabilized human neuroblastoma SH-SY5Y cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1453685&form=6&db=m Regulation of neurite outgrowth through protein kinase C and protease nexin-1 in neuroblastoma cell. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1506412&form=6&db=m Protein kinase C remains functionally active during TPA induced neuronal differentiation of SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1518842&form=6&db=m Reversible structural alterations of undifferentiated and differentiated human neuroblastoma cells induced by phorbol ester. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1548459&form=6&db=m Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors. ongoing research,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1554348&form=6&db=m The effect of protein kinase C activation on muscarinic-M3- and K(+)-evoked release of [3H]noradrenaline and increases in intracellular Ca2+ in human neuroblastoma SH-SY5Y cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1592109&form=6&db=m H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659908&form=6&db=m Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C. diagnostic usage,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902412&form=6&db=m N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1917984&form=6&db=m Modulation of neurite outgrowth in neuroblastoma cells by protein kinase C and platelet-activating factor. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2013316&form=6&db=m Expression of protein kinase C-alpha (PKC-alpha) and MYCN mRNAs in human neuroblastoma cells and modulation during morphological differentiation induced by retinoic acid. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2013318&form=6&db=m Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2029733&form=6&db=m Staurosporine-induced morphological differentiation of human neuroblastoma cells. therapeutic application,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2114183&form=6&db=m Effects of retinoic acid and staurosporine on the protein kinase C activity and the morphology of two related human neuroblastoma cell lines. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119639&form=6&db=m Phospholipase D and phospholipase C in human cholinergic neuroblastoma (LA-N-2) cells: modulation by muscarinic agonists and protein kinase C. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2167677&form=6&db=m Desensitization of muscarinic M1 receptors of murine neuroblastoma cells (clone N1E-115) without receptor down-regulation and protein kinase C activity. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2290129&form=6&db=m The study of clostridial and related toxins. The search for unique mechanisms and common denominators. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2293618&form=6&db=m Protein kinase C and its 80-kilodalton substrate protein in neuroblastoma cell neurite outgrowth. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2351657&form=6&db=m A specific inhibitor of protein kinase C induces differentiation of neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2387413&form=6&db=m The specific inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), induces morphological change and cell differentiation of human neural crest-derived cell lineages. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502430&form=6&db=m Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550478&form=6&db=m Protein kinase C activation and down-regulation in relation to phorbol ester-induced differentiation of SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2559978&form=6&db=m cis-Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2590242&form=6&db=m Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2591531&form=6&db=m Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2764930&form=6&db=m (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2792369&form=6&db=m Inhibition of protein kinase C induces differentiation of neuroblastoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849940&form=6&db=m Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2912965&form=6&db=m Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3015642&form=6&db=m The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115). ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3082882&form=6&db=m Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells. therapeutic application,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6256479&form=6&db=m Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7500380&form=6&db=m Protein kinase C-alpha and -epsilon are enriched in growth cones of differentiating SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7514011&form=6&db=m Basic FGF and IGF-I promote differentiation of human SH-SY5Y neuroblastoma cells in culture. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535173&form=6&db=m Protein kinase C inhibitors, H7 and calphostin C, inhibit induction of DNA synthesis by cytosolic extracts of exponentially growing neuroblastoma cells in isolated nuclei. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535423&form=6&db=m Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7540748&form=6&db=m Enhancement of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by phorbol esters with and without activation of protein kinase C. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7553605&form=6&db=m Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7561851&form=6&db=m Evidence that the modulation of membrane-associated protein kinase C activity by an endogenous inhibitor plays a role in N1E-115 murine neuroblastoma cell differentiation. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7595942&form=6&db=m Direct modulation of Na+ currents by protein kinase C activators in mouse neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7616205&form=6&db=m Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7654025&form=6&db=m Inhibitors of protein kinases induce differentiation in human neuroblastoma cell lines. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7656899&form=6&db=m Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7748314&form=6&db=m Evaluation of ethanol effects on PLC signal transduction pathways using cell lines of neuronal origin. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7794922&form=6&db=m Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7815513&form=6&db=m Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7892111&form=6&db=m Diacylglycerol-induced activation of protein kinase C attenuates Na+ currents by enhancing inactivation from the closed state. ongoing research,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7898780&form=6&db=m The role of protein kinase C in inducing Alzheimer's A68 protein expression in the culture of human neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7932644&form=6&db=m Multiple effects of protein kinase C activators on Na+ currents in mouse neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964753&form=6&db=m Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8020472&form=6&db=m Differential nuclear localization of protein kinase C isoforms in neuroblastoma x glioma hybrid cells. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8070569&form=6&db=m Degradation of protein kinase C alpha and its free catalytic subunit, protein kinase M, in intact human neuroblastoma cells and under cell-free conditions. Evidence that PKM is degraded by mM calpain-mediated proteolysis at a faster rate than PKC. causal interaction,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8183423&form=6&db=m Muscarinic receptor-mediated increase in zeta-PKC expression in SK-N-SH human neuroblastoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224402&form=6&db=m Protein kinase C subtypes associated with the regulation of noradrenaline release in human SH-SY5Y neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8280132&form=6&db=m The selective protein kinase C inhibitor GF 109203X inhibits phorbol ester-induced morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8297348&form=6&db=m A role for protein kinase C subtypes alpha and epsilon in phorbol-ester-enhanced K(+)- and carbachol-evoked noradrenaline release from the human neuroblastoma SH-SY5Y. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8320719&form=6&db=m Whole-cell recording of neuroblastoma x glioma cells during downregulation of a major substrate, 80K/MARCKS, of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8344386&form=6&db=m PKC activity and PKC-alpha mRNA content are reduced in serum-derived human neuroblastoma cells without concomitant induction of differentiation. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8412521&form=6&db=m Local anaesthetics do not affect protein kinase C function in intact neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8417148&form=6&db=m Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8455032&form=6&db=m Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8461005&form=6&db=m Protein kinase C-alpha but not protein kinase C-epsilon is differentially down-regulated by bryostatin 1 and tetradecanoyl phorbol 13-acetate in SH-SY5Y human neuroblastoma cells. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8562475&form=6&db=m Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566315&form=6&db=m Activation of phospholipase D in SH-SY5Y neuroblastoma cells: dependence on Ca2+ and protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8609230&form=6&db=m Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627310&form=6&db=m Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8627336&form=6&db=m Overexpression of MARCKS, but not protein kinase C-alpha, increases phorbol ester-stimulated synthesis of phosphatidylcholine in human SK-N-MC neuroblastoma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632160&form=6&db=m Phorbol ester-enhanced noradrenaline secretion correlates with the presence and activity of protein kinase C-alpha in human SH-SY5Y neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670170&form=6&db=m Contrasting effects of phorbol ester and agonist-mediated activation of protein kinase C on phosphoinositide and Ca2+ signalling in a human neuroblastoma. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8738143&form=6&db=m Protein kinase C isoforms and cell proliferation in neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8780891&form=6&db=m Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells. ongoing research,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786839&form=6&db=m Phosphatidic acid activation of protein kinase C in LA-N-1 neuroblastoma cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861817&form=6&db=m Model experiments on squid axons and NG108-15 mouse neuroblastoma x rat glioma hybrid cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8873120&form=6&db=m H7, an inhibitor of protein kinase C, prevents serum-induced phosphorylation of Raf and MAP kinase in neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8878970&form=6&db=m The effect of down-regulation and long-term inhibition of protein kinase C on noradrenaline secretion in the neuroblastoma cell line SH-SY5Y. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8891255&form=6&db=m Functional corticotropin-releasing factor receptors in human neuroblastoma cells. therapeutic application,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8906563&form=6&db=m Protein kinase C isoforms and growth, differentiation and phosphatidylcholine turnover in human neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8971808&form=6&db=m In growth cones of rat cerebral neurons and human neuroblastoma cells, activation of protein kinase C causes a shift from filopodial to lamellipodial actin dynamics. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8977143&form=6&db=m Down-regulation or long-term inhibition of protein kinase C (PKC) reduces noradrenaline release evoked via either PKC-dependent or PKC-independent pathways in human SH-SY5Y neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978708&form=6&db=m Effect of continuous phorbol ester treatment on muscarinic receptor-mediated calmodulin redistribution in SK-N-SH neuroblastoma cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8978751&form=6&db=m Activation of protein kinase C-alpha and translocation of the myristoylated alanine-rich C-kinase substrate correlate with phorbol ester-enhanced noradrenaline release from SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9106263&form=6&db=m Additive effects of basic fibroblast growth factor and phorbol ester on beta-amyloid precursor protein expression and secretion. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9109386&form=6&db=m Nuclear localization of protein kinase C alpha and its association with nuclear components in neuro-2a neuroblastoma cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9190898&form=6&db=m Expression of CD44 isoforms in neuroblastoma cells is regulated by PI 3-kinase and protein kinase C. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196027&form=6&db=m 1,25-dihydroxyvitamin D3 regulates the expression of N-myc, c-myc, protein kinase C, and transforming growth factor-beta2 in neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9245701&form=6&db=m Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9253654&form=6&db=m Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9366465&form=6&db=m Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427517&form=6&db=m A protein kinase C-activating phorbol ester enhances transcription of the human DBH gene through a cyclic AMP response element in SK-N-BE(2)C cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514311&form=6&db=m Ethanol exposure potentiates fosB and junB expression induced by muscarinic receptor stimulation in neuroblastoma SH-SY5Y cells. ongoing research,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9519544&form=6&db=m Effect of palmitoylcarnitine on the cellular differentiation, proliferation and protein kinase C activity in neuroblastoma nb-2a cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9601059&form=6&db=m Overexpression of myristoylated alanine-rich C-kinase substrate enhances activation of phospholipase D by protein kinase C in SK-N-MC human neuroblastoma cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9666082&form=6&db=m Cholinergic muscarinic mechanisms regulate neuropeptide Y gene expression via protein kinase C in human neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9808705&form=6&db=m Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins. therapeutic application,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9862417&form=6&db=m Down-regulation of protein kinase C alpha and gamma and enhanced TPA-induced neurite formation in DAN-transfected neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9930730&form=6&db=m Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9931495&form=6&db=m Redistribution of F-actin and large dense-cored vesicles in the human neuroblastoma SH-SY5Y in response to secretagogues and protein kinase Calpha activation. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10209967&form=6&db=m Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10330401&form=6&db=m PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10395170&form=6&db=m Differential responses of staurosporine on protein kinase C activity and proliferation in two murine neuroblastoma cell lines. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10482351&form=6&db=m Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617602&form=6&db=m N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10653609&form=6&db=m Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10878593&form=6&db=m Uridine induces differentiation in human neuroblastoma cells via protein kinase C epsilon. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11057029&form=6&db=m Extracellular signal-regulated kinase suppression is not involved in apoptosis of neuroblastoma N2a cells induced by protein kinase C inhibition. therapeutic application,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059834&form=6&db=m Differential expression of protein kinase C subtypes during ginsenoside Rh2-lnduced apoptosis in SK-N-BE(2) and C6Bu-1 cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11149599&form=6&db=m Protein kinase C beta1 is implicated in the regulation of neuroblastoma cell growth and proliferation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238666&form=6&db=m Neuronal expression of a functional receptor for the C5a complement activation fragment. ongoing research,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11257453&form=6&db=m Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11290387&form=6&db=m Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324578&form=6&db=m [The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325] ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11488451&form=6&db=m Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11707282&form=6&db=m A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11773315&form=6&db=m A critical protein kinase C phosphorylation site on the 5-HT(1A) receptor controlling coupling to N-type calcium channels. diagnostic usage,ongoing research,unassigned 2,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12061781&form=6&db=m Palmitoylcarnitine modulates interaction protein kinase C delta-GAP-43. diagnostic usage,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068066&form=6&db=m PKC and Raf-1 inhibition-related apoptotic signalling in N2a cells. therapeutic application,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12112008&form=6&db=m Identification of PSF as a protein kinase Calpha-binding protein in the cell nucleus. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12125082&form=6&db=m Fractalkine and fractalkine receptors in human neurons and glial cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12441167&form=6&db=m Interaction of palmitoylcarnitine with protein kinase C in neuroblastoma NB-2a cells. therapeutic application,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460119&form=6&db=m The catalytic domain limits the translocation of protein kinase C alpha in response to increases in Ca2+ and diacylglycerol. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12464618&form=6&db=m N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12610653&form=6&db=m Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12697075&form=6&db=m A protein kinase Cbeta inhibitor attenuates multidrug resistance of neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12716436&form=6&db=m Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750434&form=6&db=m micro-opioid-induced desensitization of opioid receptor-like 1 and micro-opioid receptors: differential intracellular signaling determines receptor sensitivity. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12761575&form=6&db=m The regulatory domain of protein kinase Ctheta localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12927600&form=6&db=m Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14511117&form=6&db=m Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555244&form=6&db=m The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14720513&form=6&db=m Induction of neurites by the regulatory domains of PKCdelta and epsilon is counteracted by PKC catalytic activity and by the RhoA pathway. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741403&form=6&db=m The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15062566&form=6&db=m Selective activation of protein kinase C isoforms by angiotensin II in neuroblastoma X glioma cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15147504&form=6&db=m Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15189345&form=6&db=m Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15233804&form=6&db=m Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277524&form=6&db=m Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Calpha in response to diacylglycerol. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183168&form=6&db=m Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16341931&form=6&db=m Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16519693&form=6&db=m Palmitoylcarnitine modulates interaction between protein kinase C betaII and its receptor RACK1. diagnostic usage,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16546434&form=6&db=m Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16672766&form=6&db=m Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16684511&form=6&db=m Increased isoform-specific membrane translocation of conventional and novel protein kinase C in human neuroblastoma SH-SY5Y cells following prolonged hypoxia. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16945114&form=6&db=m Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17017568&form=6&db=m Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17080406&form=6&db=m Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17148779&form=6&db=m Receptor regulation of the volume-sensitive efflux of taurine and iodide from human SH-SY5Y neuroblastoma cells: differential requirements for Ca(2+) and protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697049&form=6&db=m A novel PIP2 binding of epsilonPKC and its contribution to the neurite induction ability. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17945434&form=6&db=m Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18374307&form=6&db=m Transglutaminase 2 and NF-kappaB interplay during NGF-induced differentiation of neuroblastoma cells. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408015&form=6&db=m Protein kinase Cepsilon binds peripherin and induces its aggregation, which is accompanied by apoptosis of neuroblastoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19077250&form=6&db=m Protein kinase Cepsilon is important for migration of neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120063&form=6&db=m Long-term ethanol exposure impairs neuronal differentiation of human neuroblastoma cells involving neurotrophin-mediated intracellular signaling and in particular protein kinase C. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20074641&form=6&db=m PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20139073&form=6&db=m Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20504720&form=6&db=m Bradykinin-induced phosphoinositide-dependent responses in protein kinase C down-regulated NCB-20 cells. ongoing research,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20575782&form=6&db=m Chronic effects of ethanol on muscarinic acetylcholine receptors are modulated by protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081127&form=6&db=m Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21554319&form=6&db=m ?-N-oxalyl-L-?,?-diaminopropionic acid regulates mitogen-activated protein kinase signaling by down-regulation of phosphatidylethanolamine-binding protein 1. ongoing research,unassigned 3,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22732405&form=6&db=m Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22798207&form=6&db=m TRAIL resistance in human neuroblastoma SK-N-AS cells is dependent on protein kinase C and involves inhibition of caspase-3 proteolytic processing. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23155231&form=6&db=m Protein kinase C regulates bombesin-induced rapid VEGF secretion in neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23224819&form=6&db=m Palmitoylcarnitine affects localization of growth associated protein GAP-43 in plasma membrane subdomains and its interaction with G?(o) in neuroblastoma NB-2a cells. unassigned - 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24141119&form=6&db=m The thiol proteinase inhibitor E-64-d ameliorates amyloid-?-induced reduction of sAPP? secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells. ongoing research,unassigned 1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24650665&form=6&db=m Involvement of diacylglycerol produced by phospholipase D activation in A?-induced reduction of sAPP? secretion in SH-SY5Y neuroblastoma cells. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25523949&form=6&db=m Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C ? in human neuroblastoma dopaminergic SH-SY5Y cell lines. ongoing research,unassigned 2,0 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30541014&form=6&db=m Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces ?-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33020912&form=6&db=m The role of protein kinase C alpha in tri-ortho-cresyl phosphate-induced autophagy in human neuroblastoma SK-N-SH cells. ongoing research,unassigned 4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907262&form=6&db=m Survival-promoting and protein kinase C-regulating roles of basic FGF for hippocampal neurons exposed to phorbol ester, glutamate and ischaemia-like conditions. causal interaction,unassigned 4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8746795&form=6&db=m Age does not alter Protein kinase C isozymes mRNA expression in rat brain. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12927600&form=6&db=m Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15994023&form=6&db=m Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691113&form=6&db=m Atypical protein kinase C in neurodegenerative disease I: PKMzeta aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer disease. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892365&form=6&db=m Synthesis and Pharmacological Evaluation of 8- and 9-Substituted Benzolactam-V8 Derivatives as Potent Ligands for Protein Kinase C, a Therapeutic Target for Alzheimer's Disease. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17822669&form=6&db=m Protection from ataxia-linked apoptosis by gap junction inhibitors. causal interaction,unassigned 4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18005063&form=6&db=m Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress. causal interaction,unassigned 4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577575&form=6&db=m PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056342&form=6&db=m Loss of Purkinje cells in the PKCgamma H101Y transgenic mouse. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19233655&form=6&db=m Neuroprotective versus tumorigenic protein kinase C activators. therapeutic application,unassigned 1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192567&form=6&db=m Curcumin: from food spice to cancer prevention. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20478365&form=6&db=m Atypical protein kinase C expression in phrenic motor neurons of the rat. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582866&form=6&db=m Drug Development for Neurodegenerative Diseases--Second Annual marcus evans Conference. Advances in drug development for NDD and expediting discovery through novel compounds and sound clinical trials. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979579&form=6&db=m The PKC-? interacting protein ZIP3 is generated by intronic polyadenylation and is expressed in brain and retina of the rat. causal interaction,unassigned 1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21906004&form=6&db=m Molecular pathophysiology of neurodegenerative disease caused by ?PKC mutations. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949352&form=6&db=m Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila. causal interaction,diagnostic usage,unassigned 2,3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22474074&form=6&db=m Small interfering RNA-mediated knockdown of protein kinase C zeta attenuates domoic acid-induced cognitive deficits in mice. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25217572&form=6&db=m Identification and characterization of PKC?, a kinase associated with SCA14, as an amyloidogenic protein. therapeutic application,unassigned 1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904794&form=6&db=m Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29335220&form=6&db=m Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2´, 4, 4´-tetrabromodiphenyl ether (BDE-47)-treated mice. therapeutic application,unassigned 4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29920240&form=6&db=m Scallop-derived plasmalogens attenuate the activation of PKC? associated with the brain inflammation. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30312605&form=6&db=m Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. causal interaction,unassigned 3,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338269&form=6&db=m Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31233882&form=6&db=m Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31318159&form=6&db=m Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice. therapeutic application,unassigned 1,0 2.7.11.13 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32120776&form=6&db=m Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression. causal interaction,unassigned 1,0 2.7.11.13 Neurogenic Inflammation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18752301&form=6&db=m Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation. ongoing research,unassigned 3,0 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17331203&form=6&db=m PKCepsilon induces astrocyte stellation by modulating multiple cytoskeletal proteins and interacting with Rho A signalling pathways: implications for neuroinflammation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20640460&form=6&db=m A proteomic analysis of PKCepsilon targets in astrocytes: implications for astrogliosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24883061&form=6&db=m Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets. unassigned - 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26455476&form=6&db=m Caruifolin D from artemisia absinthium L. inhibits neuroinflammation via reactive oxygen species-dependent c-jun N-terminal kinase and protein kinase c/NF-?B signaling pathways. unassigned - 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27094771&form=6&db=m Suppression of PKC-? attenuates TNF-?-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29920240&form=6&db=m Scallop-derived plasmalogens attenuate the activation of PKC? associated with the brain inflammation. causal interaction,unassigned 3,0 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32673674&form=6&db=m Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860212&form=6&db=m Intracellular Signaling Cascades in Bipolar Disorder. therapeutic application,unassigned 1,0 2.7.11.13 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33472023&form=6&db=m Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17060026&form=6&db=m Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245514&form=6&db=m Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057900&form=6&db=m Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16932311&form=6&db=m Mechanisms of Disease: hepatic steatosis in type 2 diabetes--pathogenesis and clinical relevance. causal interaction,unassigned 2,0 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130651&form=6&db=m Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. causal interaction,unassigned 4,0 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19022218&form=6&db=m PKCepsilon plays a causal role in acute ethanol-induced steatosis. therapeutic application,unassigned 1,0 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24454937&form=6&db=m Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis. ongoing research,unassigned 2,0 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29046367&form=6&db=m PKC? silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity. unassigned - 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30573200&form=6&db=m Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models. unassigned - 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30907226&form=6&db=m Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. unassigned - 2.7.11.13 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31220350&form=6&db=m Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ?. causal interaction,unassigned 1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2649084&form=6&db=m Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670164&form=6&db=m Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states. unassigned - 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9324113&form=6&db=m Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle? causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9335553&form=6&db=m Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10923637&form=6&db=m Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11478406&form=6&db=m Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats. causal interaction,unassigned 1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11896487&form=6&db=m Impaired glucose metabolism in the heart of obese Zucker rats after treatment with phorbol ester. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778364&form=6&db=m Endothelial cell specific molecule-1--a newly identified protein in adipocytes. causal interaction,unassigned 3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882908&form=6&db=m Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13680127&form=6&db=m Fatty acid metabolism and insulin secretion in pancreatic beta cells. unassigned - 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715497&form=6&db=m Protein kinase betaII in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16179727&form=6&db=m Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16896164&form=6&db=m Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17028898&form=6&db=m Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans. unassigned - 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962198&form=6&db=m Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18086904&form=6&db=m Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18370676&form=6&db=m Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19202134&form=6&db=m Critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappa B in obesity. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19296465&form=6&db=m Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20816195&form=6&db=m Analyses of shared genetic factors between asthma and obesity in children. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21550971&form=6&db=m Disruption of the murine protein kinase Cbeta gene promotes gallstone formation and alters biliary lipid and hepatic cholesterol metabolism. unassigned - 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449812&form=6&db=m Atypical protein kinase C in cardiometabolic abnormalities. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23392873&form=6&db=m Reduced Placental Taurine Transporter (TauT) Activity in Pregnancies Complicated by Pre-eclampsia and Maternal Obesity. causal interaction,unassigned 1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23606925&form=6&db=m Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23700535&form=6&db=m Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance. causal interaction,unassigned 4,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25379403&form=6&db=m Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25395359&form=6&db=m Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation. unassigned - 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26237474&form=6&db=m Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26307588&form=6&db=m Role of PKC? in Insulin Sensitivity and Skeletal Muscle Metabolism. causal interaction,unassigned 3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26386696&form=6&db=m BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1? in livers of obese and type 2 diabetic humans. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26569333&form=6&db=m Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. therapeutic application,unassigned 1,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073831&form=6&db=m Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28144885&form=6&db=m Effects of obesity on protein kinase C, brain creatine kinase, transcription, and autophagy in cochlea. ongoing research,unassigned 3,0 2.7.11.13 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34388531&form=6&db=m Mechanistic insight into high-fat diet-induced metabolic inflammation in the arcuate nucleus of the hypothalamus. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Olivopontocerebellar Atrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655168&form=6&db=m Inositol 1,4,5-trisphosphate receptors and protein kinase C in olivopontocerebellar atrophy. unassigned - 2.7.11.13 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8648258&form=6&db=m Protein kinase C activator inhibits progression of osteoarthritis induced in rabbit knee joints. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9280149&form=6&db=m Cyclic tensile stretch on bovine articular chondrocytes inhibits protein kinase C activity. ongoing research,unassigned 3,0 2.7.11.13 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052323&form=6&db=m Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation. ongoing research,unassigned 2,0 2.7.11.13 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16798739&form=6&db=m Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20646344&form=6&db=m Divergent effects of infliximab and anakinra therapies on macrophage phenotype from patients with refractory rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.7.11.13 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20962279&form=6&db=m Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. causal interaction,unassigned 2,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336300&form=6&db=m Protein kinase C modulates parathyroid hormone- but not prostaglandin E2-mediated stimulation of cyclic AMP production via the inhibitory guanine nucleotide binding protein in UMR-106 osteosarcoma cells. therapeutic application,unassigned 1,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1645255&form=6&db=m Protein kinase C is involved in PTH-induced homologous desensitization by directly affecting PTH receptor in the osteoblastic osteosarcoma cells. therapeutic application,unassigned 1,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647845&form=6&db=m Prostaglandin-induced changes in calcium uptake and cAMP production in osteoblast-like cells: role of protein kinase C. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662087&form=6&db=m Protein kinase C activating phorbolesters enhance the cyclic AMP response to parathyroid hormone, forskolin and choleratoxin in mouse calvarial bones and rat osteosarcoma cells. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1688464&form=6&db=m Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1733255&form=6&db=m Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2171507&form=6&db=m Parathyroid hormone fragment [3-34] stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphoma cells. ongoing research,unassigned 4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2479539&form=6&db=m A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C. causal interaction,unassigned 1,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537172&form=6&db=m Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3471217&form=6&db=m Possible involvement of protein kinase C in parathyroid hormone degradation by osteoblast-like rat osteosarcoma cell line UMR106. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3471324&form=6&db=m Time-dependent changes in protein kinase C distribution and disappearance in phorbol ester-treated human osteosarcoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3476487&form=6&db=m Evidence for increased synthesis as well as increased degradation of protein kinase C after treatment of human osteosarcoma cells with phorbol ester. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7678725&form=6&db=m Regulation of the TNF-alpha receptor in human osteosarcoma cells: role of microtubules and of protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7928086&form=6&db=m Structure and protein kinase C stimulating activities of lactam analogues of human parathyroid hormone fragment. ongoing research,unassigned 4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8123038&form=6&db=m Vinblastine-dependent down-modulation of TNF receptors in human osteosarcoma cells is mediated by protein kinase C activity. ongoing research,unassigned 1,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8402575&form=6&db=m Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells. ongoing research,unassigned 4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8475799&form=6&db=m Protein kinase C-activating domains of parathyroid hormone-related protein. unassigned - 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9073607&form=6&db=m The effect of cadmium on cytosolic free calcium, protein kinase C, and collagen synthesis in rat osteosarcoma (ROS 17/2.8) cells. ongoing research,unassigned 4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175844&form=6&db=m Cadmium perturbs calcium homeostasis in rat osteosarcoma (ROS 17/2.8) cells; a possible role for protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9397948&form=6&db=m Phorbol 12-myristate 13-acetate and 1,25-dihydroxyvitamin D3 regulate 1,25-dihydroxyvitamin D3 receptors synergistically in rat osteosarcoma cells. ongoing research,unassigned 4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751512&form=6&db=m Type-1 parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(1-34). ongoing research,unassigned 2,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353689&form=6&db=m Stimulation of membrane-associated protein kinase-C activity in spleen lymphocytes by hPTH-(1-31)NH2, its lactam derivative, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, and hPTH-(1-30)NH2. ongoing research,unassigned 2,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11557365&form=6&db=m Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11598907&form=6&db=m Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR-108 osteoblastic cells. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11911960&form=6&db=m 1,25-Dihydroxyvitamin D3 selectively translocates PKCalpha to nuclei in ROS 17/2.8 cells. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559394&form=6&db=m Thiol oxidation by 2,2'-dithiodipyridine induced calcium mobilization in MG63 human osteosarcoma cells. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928766&form=6&db=m Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells. ongoing research,unassigned 3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14704980&form=6&db=m Gene expression changes in BALB/3T3 transformants induced by poly(L-lactic acid) or polyurethane films. therapeutic application,unassigned 1,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18507025&form=6&db=m Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21848623&form=6&db=m Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24216982&form=6&db=m Protein kinase C epsilon and genetic networks in osteosarcoma metastasis. causal interaction,diagnostic usage,unassigned 2,3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25252845&form=6&db=m Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31360197&form=6&db=m Inhibition of protein kinase C activity inhibits osteosarcoma metastasis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32847038&form=6&db=m CXCL13/CXCR5 Interaction Facilitates VCAM-1-Dependent Migration in Human Osteosarcoma. ongoing research,unassigned 1,0 2.7.11.13 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17191118&form=6&db=m The role of PKCzeta in amikacin-induced apoptosis in the cochlea: prevention by aspirin. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1930266&form=6&db=m The role of protein kinase C and the phosphatidylinositol cycle in multidrug resistance in human ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9103395&form=6&db=m Collagenase expression in ovarian cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459150&form=6&db=m Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9523737&form=6&db=m Gemcitabine induces programmed cell death and activates protein kinase C in BG-1 human ovarian cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9604994&form=6&db=m The effect of protein kinase C inhibitors on invasion of human ovary cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9615708&form=6&db=m Expression analysis of protein kinase C isozymes and multidrug resistance associated genes in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10497304&form=6&db=m Antisense oligonucleotides as therapeutic agents. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10537288&form=6&db=m Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12553062&form=6&db=m Induction of drug resistance and protein kinase C genes in A2780 ovarian cancer cells after incubation with antineoplastic agents at sublethal concentrations. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459489&form=6&db=m Protein kinase C alpha expression in breast and ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16116079&form=6&db=m Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16283480&form=6&db=m KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16601289&form=6&db=m Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16651413&form=6&db=m Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17678893&form=6&db=m Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17724468&form=6&db=m Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18619662&form=6&db=m Protein kinase C inhibitor Gö6976 augments caffeine-induced reversal of chemoresistance to cis-diamminedichloroplatinum-II (CDDP) in a human ovarian cancer model. ongoing research,unassigned 3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19563063&form=6&db=m [Expression of connexin 43 in ovarian cancer and its relationship with chemoresistance] diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20384629&form=6&db=m Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501645&form=6&db=m Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20936324&form=6&db=m Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium study. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23098446&form=6&db=m Modulation of drug resistance in ovarian cancer cells by inhibition of protein kinase C-alpha (PKC-?) with small interference RNA (siRNA) agents. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25111382&form=6&db=m Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes. causal interaction,unassigned 3,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502607&form=6&db=m A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,2 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25874946&form=6&db=m Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26279297&form=6&db=m PKCiota promotes ovarian tumor progression through deregulation of cyclin E. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33037137&form=6&db=m Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33383102&form=6&db=m Evaluating the current status of protein kinase C (PKC)-protein kinase D (PKD) signalling axis as a novel therapeutic target in ovarian cancer. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34414590&form=6&db=m Receptor interacting protein kinase 4 promotes cell proliferation, migration, and invasion in ovarian cancer via targeting protein kinase C delta. causal interaction,unassigned 1,0 2.7.11.13 Pancreatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28826907&form=6&db=m Protein kinase C isoforms in the normal pancreas and in pancreatic disease. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7546218&form=6&db=m Dietary energy restriction-induced modulation of protein kinase C zeta isozyme in the hamster pancreas. causal interaction,unassigned 1,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9706141&form=6&db=m Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10339669&form=6&db=m Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10934041&form=6&db=m Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912133&form=6&db=m Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12107546&form=6&db=m A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645342&form=6&db=m Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604996&form=6&db=m Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707447&form=6&db=m Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer. causal interaction,unassigned 4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17507797&form=6&db=m PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006785&form=6&db=m Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437080&form=6&db=m Protein kinase C: a target for therapy in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19043530&form=6&db=m Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19924022&form=6&db=m PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179210&form=6&db=m Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20684793&form=6&db=m PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21381080&form=6&db=m Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA-methylation in human pancreatic cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160590&form=6&db=m Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22359542&form=6&db=m Protein Kinase C Iota Regulates Pancreatic Acinar-to-Ductal Metaplasia. causal interaction,unassigned 3,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23639786&form=6&db=m Norepinephrine inhibits the migratory activity of pancreatic cancer cells. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23962904&form=6&db=m Phase I dose escalation study of the PKC? inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer. causal interaction,unassigned 4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24015205&form=6&db=m Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism. ongoing research,unassigned 4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152584&form=6&db=m Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,4 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25604078&form=6&db=m Targeting protein kinase C subtypes in pancreatic cancer. diagnostic usage,unassigned 2,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25624908&form=6&db=m Tamoxifen enhances the anticancer effect of cantharidin and norcantharidin in pancreatic cancer cell lines through inhibition of the protein kinase C signaling pathway. therapeutic application,unassigned 1,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25915428&form=6&db=m A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26590425&form=6&db=m K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27424921&form=6&db=m Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31230347&form=6&db=m Mu-KRAS attenuates Hippo signaling pathway through PKC? to sustain the growth of pancreatic cancer. causal interaction,unassigned 4,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14724052&form=6&db=m Restoration of spontaneous exploratory behaviors with an intrathecal NMDA receptor antagonist or a PKC inhibitor in rats with acute pancreatitis. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083718&form=6&db=m Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16214426&form=6&db=m Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16718817&form=6&db=m Hyperlipidemia intensifies cerulein-induced acute pancreatitis associated with activation of protein kinase C in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17408632&form=6&db=m Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis. ongoing research,unassigned 3,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653813&form=6&db=m Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336661&form=6&db=m Protein kinase C in the pancreatic acinar cell. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18388183&form=6&db=m The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18436016&form=6&db=m Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20947701&form=6&db=m A NOVEL PROTEIN KINASE D INHIBITOR ATTENUATES EARLY EVENTS OF EXPERIMENTAL PANCREATITIS IN ISOLATED RAT ACINI. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2161375&form=6&db=m Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645342&form=6&db=m Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1638676&form=6&db=m Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7908201&form=6&db=m Focal transgene expression associated with papilloma development in v-Ha-ras-transgenic TG.AC mice. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8062222&form=6&db=m Expression of protein kinase C isoforms in skin papilloma and carcinoma of mice. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8242857&form=6&db=m Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676642&form=6&db=m Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10969783&form=6&db=m A role for protein kinase C-delta in the regulation of ornithine decarboxylase expression by oxidative stress. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477572&form=6&db=m Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243773&form=6&db=m Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Paraganglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18039096&form=6&db=m Von hippel-lindau disease. causal interaction,unassigned 4,0 2.7.11.13 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8584425&form=6&db=m On the possible origin of giant or slow-rising miniature end-plate potentials at the neuromuscular junction. unassigned - 2.7.11.13 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2778438&form=6&db=m Differential phosphorylation of the nucleoprotein of influenza A viruses. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7645259&form=6&db=m Human parainfluenza virus type 3 phosphoprotein: identification of serine 333 as the major site for PKC zeta phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7761474&form=6&db=m Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9195969&form=6&db=m Phosphorylation of Sendai virus phosphoprotein by cellular protein kinase C zeta. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Paraneoplastic Cerebellar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2285268&form=6&db=m General assay for phosphoproteins in cerebrospinal fluid: a candidate marker for paraneoplastic cerebellar degeneration. unassigned - 2.7.11.13 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10092881&form=6&db=m Molecular cloning, cell localization and binding affinity to DNA replication proteins of the p36/LACK protective antigen from Leishmania infantum. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,2 2.7.11.13 Parathyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19020789&form=6&db=m Primary hyperparathyroidism: role of the preoperative oral calcium loading test in the differential diagnosis between adenoma and hyperplasia. causal interaction,unassigned 3,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8093576&form=6&db=m Second messenger systems in brains of patients with Parkinson's or Huntington's disease. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15893856&form=6&db=m Alteration of protein kinase C conformation in red blood cells: a potential marker for Alzheimer's disease but not for Parkinson's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15961393&form=6&db=m Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. therapeutic application,unassigned 1,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17045926&form=6&db=m A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553932&form=6&db=m Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565007&form=6&db=m Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18923405&form=6&db=m Target identification for CNS diseases by transcriptional profiling. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18945348&form=6&db=m Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. unassigned - 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633700&form=6&db=m Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582866&form=6&db=m Drug Development for Neurodegenerative Diseases--Second Annual marcus evans Conference. Advances in drug development for NDD and expediting discovery through novel compounds and sound clinical trials. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23436724&form=6&db=m Protein interacting with C kinase and neurological disorders. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904794&form=6&db=m Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970394&form=6&db=m Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338269&form=6&db=m Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32728898&form=6&db=m Integrative Analysis of Gene Expression and Regulatory Network Interaction Data Reveals the Protein Kinase C Family of Serine/Threonine Receptors as a Significant Druggable Target for Parkinson's Disease. causal interaction,unassigned 2,0 2.7.11.13 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32762399&form=6&db=m A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. causal interaction,unassigned 1,0 2.7.11.13 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276337&form=6&db=m PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway. causal interaction,unassigned 1,0 2.7.11.13 Parvoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829844&form=6&db=m Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice. therapeutic application,unassigned 1,0 2.7.11.13 Parvoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042254&form=6&db=m Parvovirus interference with intracellular signalling: mechanism of PKCeta activation in MVM-infected A9 fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Pemphigoid, Bullous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11641060&form=6&db=m Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line. ongoing research,unassigned 2,0 2.7.11.13 Pemphigoid, Bullous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27775687&form=6&db=m Macropinocytosis of type XVII collagen induced by bullous pemphigoid IgG is regulated via protein kinase C. unassigned - 2.7.11.13 Pemphigus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9077478&form=6&db=m Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes. ongoing research,unassigned 4,0 2.7.11.13 Pemphigus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10536988&form=6&db=m Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell datachment induced by pemphigus IgG in cultured keratinocytes: involvement of protein kinase C. unassigned - 2.7.11.13 Pemphigus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10638334&form=6&db=m Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Pemphigus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574391&form=6&db=m Beyond steric hindrance: the role of adhesion signaling pathways in the pathogenesis of pemphigus. causal interaction,unassigned 3,0 2.7.11.13 Pemphigus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18073210&form=6&db=m Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10872962&form=6&db=m Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis. causal interaction,unassigned 1,0 2.7.11.13 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8158498&form=6&db=m Chemoluminescence generation and MTT dye reduction by polymorphonuclear leukocytes from periodontal disease patients. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081595&form=6&db=m Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1393564&form=6&db=m Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury. causal interaction,unassigned 3,0 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375678&form=6&db=m The types of neuron which contain protein kinase C gamma in rat spinal cord. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14550765&form=6&db=m Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit. ongoing research,unassigned 2,0 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667440&form=6&db=m Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009134&form=6&db=m Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord. unassigned - 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17586495&form=6&db=m Pain behaviors after spinal cord contusion injury in two commonly used mouse strains. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18387748&form=6&db=m Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24843457&form=6&db=m Mechanism of diabetic neuropathy: Where are we now and where to go? unassigned - 2.7.11.13 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055342&form=6&db=m Mechanisms of pain in sickle cell disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789620&form=6&db=m Ruboxistaurin (Eli Lilly). causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809704&form=6&db=m Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715401&form=6&db=m Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199243&form=6&db=m Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial. therapeutic application,unassigned 4,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392551&form=6&db=m A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17472415&form=6&db=m Ruboxistaurin: LY 333531. therapeutic application,unassigned 4,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17502419&form=6&db=m Myelin protein zero/P0 phosphorylation and function require an adaptor protein linking it to RACK1 and PKC alpha. causal interaction,unassigned 3,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17639971&form=6&db=m [Survey of current experimental studies of effects of traditional Chinese compound recipe on diabetic peripheral neuropathy] unassigned - 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18280438&form=6&db=m Endothelial and neural regulation of skin microvascular blood flow in patients with diabetic peripheral neuropathy: effect of treatment with the isoform-specific protein kinase C beta inhibitor, ruboxistaurin. therapeutic application,unassigned 3,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19614949&form=6&db=m Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26180187&form=6&db=m Identifying the Role of Novel Protein Kinase C Isoforms in Mediating Paclitaxel-Induced Peripheral Neuropathy. ongoing research,unassigned 1,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116739&form=6&db=m Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30679921&form=6&db=m Activating transcription factor 3 modulates protein kinase C epsilon activation in diabetic peripheral neuropathy. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33949936&form=6&db=m Treatment for diabetic peripheral neuropathy: What have we learned from animal models? causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1475278&form=6&db=m Inhibition by protein kinase C activation of melittin-induced arachidonic acid release in PC12 pheochromocytoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1635552&form=6&db=m Staurosporine-induced neurite outgrowth in PC12 cells is independent of protein kinase C inhibition. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1881614&form=6&db=m Protein kinase C in human pheochromocytoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157719&form=6&db=m Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2186928&form=6&db=m Nerve growth factor stimulates protein kinase C translocation in PC12 cells. ongoing research,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2418837&form=6&db=m Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cells. ongoing research,unassigned 1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537833&form=6&db=m Nerve growth factor-induced changes in the intracellular localization of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2785993&form=6&db=m Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2874140&form=6&db=m Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase. unassigned - 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3002860&form=6&db=m The protein kinase C activator phorbol-12-myristate-13-acetate enhances cyclic AMP accumulation in pheochromocytoma cells. ongoing research,unassigned 2,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3162237&form=6&db=m Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3533064&form=6&db=m Nerve growth factor enhances the level of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6151178&form=6&db=m Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. unassigned - 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7507513&form=6&db=m Expression of tyrosine hydroxylase gene in cultured hypothalamic cells: roles of protein kinase A and C. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7557837&form=6&db=m Genistein inhibits Ca2+ influx by extracellular ATP in PC12 pheochromocytoma cells. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7759058&form=6&db=m Pituitary adenylate cyclase-activating polypeptide autoregulates cAMP production due to activation of protein kinase C in PC12 pheochromocytoma cells. causal interaction,unassigned 1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7836756&form=6&db=m Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig. unassigned - 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7857779&form=6&db=m Nerve growth factor-induced differentiation of PC12 cells employs the PMA-insensitive protein kinase C-zeta isoform. causal interaction,unassigned 1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7907091&form=6&db=m Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7917831&form=6&db=m Synergistic effects between protein kinase C and cAMP on activator protein-1 activity and differentiation of PC-12 pheochromocytoma cells. ongoing research,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7971149&form=6&db=m Differential modulation of pharmacologically distinct components of Ca2+ currents by protein kinase C activators and phosphatase inhibitors in nerve-growth-factor-differentiated rat pheochromocytoma (PC12) cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8100714&form=6&db=m Activation of soluble guanylate cyclase through phosphorylation by protein kinase C in intact PC12 cells. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8240290&form=6&db=m Nerve growth factor activates calcium-insensitive protein kinase C-epsilon in PC-12 rat pheochromocytoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8347595&form=6&db=m Activation of UDP-galactose:globotriaosylceramide alpha 1-3-galactosyltransferase during PC12D cell differentiation induced by galactosylceramide. unassigned - 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8543566&form=6&db=m Effects of protein kinase C and A activation on ATP-stimulated release of [3H]noradrenaline from PC12 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612693&form=6&db=m Changes of nuclear protein kinase C activity and isotype composition in PC12 cell proliferation and differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9276735&form=6&db=m Stimulus coupling to transcription versus secretion in pheochromocytoma cells. Convergent and divergent signal transduction pathways and the crucial roles for route of cytosolic calcium entry and protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388266&form=6&db=m Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells. causal interaction,unassigned 1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9617484&form=6&db=m Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells. ongoing research,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10944456&form=6&db=m Neuronal differentiation of PC12 cells involves changes in protein kinase C-theta distribution and molecular properties. ongoing research,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725031&form=6&db=m Differential Effects of Glycosphingolipids n Protein Kinase C Activity in PC12D Pheochromocytoma Cells. ongoing research,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11744693&form=6&db=m Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11911850&form=6&db=m Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells. ongoing research,unassigned 3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488334&form=6&db=m Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells. unassigned - 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12590138&form=6&db=m Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells. ongoing research,unassigned 1,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15062979&form=6&db=m Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells. causal interaction,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466860&form=6&db=m Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. ongoing research,unassigned 3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15686491&form=6&db=m Distinct roles of PKC isoforms in NCAM-mediated neurite outgrowth. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15814842&form=6&db=m The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells. ongoing research,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878642&form=6&db=m Protein kinase Calpha modulates depolarizaton-evoked changes of intracellular Ca2+ concentration in a rat pheochromocytoma cell line. ongoing research,unassigned 3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16179541&form=6&db=m Novel Neuroprotective Mechanism of Action of Rasagiline Is Associated with Its Propargyl Moiety: Interaction of Bcl-2 Family Members with PKC Pathway. ongoing research,unassigned 2,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18039096&form=6&db=m Von hippel-lindau disease. causal interaction,unassigned 4,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19048456&form=6&db=m Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.7.11.13 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656694&form=6&db=m Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Photophobia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9379174&form=6&db=m Protein kinase C activity and light sensitivity of single amphibian rods. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Pick Disease of the Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1453879&form=6&db=m PMA-sensitive protein kinase C is not necessary in TRH-stimulated prolactin release from female rat primary pituitary cells. unassigned - 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904062&form=6&db=m Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2293616&form=6&db=m Effects of protein kinase C down-regulation on secretory events and proopiomelanocortin gene expression in anterior pituitary tumor (AtT-20) cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2449624&form=6&db=m The protein kinase C activator 1-oleoyl-2-acetylglycerol inhibits voltage-dependent Ca2+ current in the pituitary cell line AtT-20. ongoing research,unassigned 3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2458349&form=6&db=m Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823094&form=6&db=m Activators of protein kinase C and cyclic AMP-dependent protein kinase regulate intracellular calcium levels through distinct mechanisms in mouse anterior pituitary tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824497&form=6&db=m Stimulation of protein synthesis in pituitary cells by phorbol esters and cyclic AMP. Evidence for rapid induction of a component of translational initiation. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3025360&form=6&db=m Translocation of protein kinase C in anterior pituitary tumor cells. causal interaction,unassigned 4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3124990&form=6&db=m Hormone-induced redistribution of protein kinase C in human pituitary adenomas. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3925349&form=6&db=m Bidirectional control of cytosolic free calcium by thyrotropin-releasing hormone in pituitary cells. ongoing research,unassigned 3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7526863&form=6&db=m Phorbol ester activation of protein kinase C inhibits CNP-stimulated cyclic GMP production in the mouse AtT-20 pituitary tumour cell line. therapeutic application,unassigned 1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651730&form=6&db=m The natural protein kinase C alpha mutant is present in human thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7670732&form=6&db=m Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells. ongoing research,unassigned 3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7704445&form=6&db=m Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C. unassigned - 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7802423&form=6&db=m [Etiopathogenesis of pituitary tumors] causal interaction,unassigned 4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8097303&form=6&db=m Immunohistochemical expression of protein kinase C type III in human pituitary adenomas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8404612&form=6&db=m Thyrotropin-releasing hormone stimulates c-jun and c-fos messenger ribonucleic acid levels: implications for calcium mobilization and protein kinase-C activation. therapeutic application,unassigned 1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8434650&form=6&db=m Protein kinase C (PKC) activity and PKC messenger RNAs in human pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8479155&form=6&db=m Protein kinase C activity and messenger RNA modulation by estrogen in normal and neoplastic rat pituitary tissue. causal interaction,unassigned 3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8596491&form=6&db=m Growth hormone secretion in human acromegalic pituitary adenomas: cyclic adenosine monophosphate and protein kinase C responses. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8738488&form=6&db=m Protein kinase C and growth regulation of pituitary adenomas. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8755764&form=6&db=m Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8799890&form=6&db=m Activation of protein kinase C inhibits calcium-activated potassium channels in rat pituitary tumour cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038375&form=6&db=m Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9135578&form=6&db=m Analysis of a protein kinase C-alpha mutation in human pituitary tumours. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9156516&form=6&db=m The roles of adenosine 3',5'-cyclic monophosphate-dependent protein kinase A and protein kinase C in stimulus-secretion coupling in AtT-20 cells. ongoing research,unassigned 2,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167945&form=6&db=m Protein kinase C alpha and tumorigenesis of the endocrine gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994357&form=6&db=m Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169386&form=6&db=m Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway. causal interaction,unassigned 4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173071&form=6&db=m Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12238950&form=6&db=m Positive feedback of protein kinase C proteolytic activation during apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12715105&form=6&db=m [Influence of ACh on the level of protein kinase C, intracellular free Ca(2+) and cyclic AMP/cyclic GMP of cultured human pituitary adenoma cells] causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17133362&form=6&db=m Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19595700&form=6&db=m Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage. causal interaction,unassigned 4,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20798497&form=6&db=m GH3B6 pituitary tumor cell proliferation is mediated by PKCalpha and PKCepsilon via ERK 1/2-dependent pathway. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28656882&form=6&db=m siRNA-mediated silencing of bFGF gene inhibits the proliferation, migration, and invasion of human pituitary adenoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.13 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192298&form=6&db=m Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1504056&form=6&db=m Bryostatin 1 activates T cells that have antitumor activity. ongoing research,unassigned 3,0 2.7.11.13 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1940380&form=6&db=m Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945801&form=6&db=m Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0 2.7.11.13 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8703964&form=6&db=m Mechanism of apoptosis suppression by phorbol ester in IL-6-starved murine plasmacytomas: role of PKC modulation and cell cycle. therapeutic application,unassigned 3,0 2.7.11.13 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15528385&form=6&db=m Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta. causal interaction,unassigned 4,0 2.7.11.13 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16729719&form=6&db=m PKCtheta: A potential therapeutic target for T-cell-mediated diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783200&form=6&db=m Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors. diagnostic usage,therapeutic application,unassigned 3,4,0 2.7.11.13 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007975&form=6&db=m Protein kinase Czeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. therapeutic application,unassigned 3,0 2.7.11.13 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211111&form=6&db=m Pulmonary endothelial protein kinase C-delta (PKC?) regulates neutrophil migration in acute lung inflammation. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32634062&form=6&db=m Organic dust-induced lung injury and repair: Bi-directional regulation by TNF? and IL-10. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Pneumoperitoneum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15973767&form=6&db=m Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.7.11.13 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9497315&form=6&db=m The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1. unassigned - 2.7.11.13 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16437702&form=6&db=m Autosomal dominant polycystic liver disease in a family without polycystic kidney disease associated with a novel missense protein kinase C substrate 80K-H mutation. causal interaction,unassigned 1,0 2.7.11.13 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24506938&form=6&db=m Polycystic liver disease: ductal plate malformation and the primary cilium. causal interaction,unassigned 1,0 2.7.11.13 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30652979&form=6&db=m Genetics of polycystic liver diseases. causal interaction,unassigned 1,0 2.7.11.13 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16437702&form=6&db=m Autosomal dominant polycystic liver disease in a family without polycystic kidney disease associated with a novel missense protein kinase C substrate 80K-H mutation. causal interaction,unassigned 1,0 2.7.11.13 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24506938&form=6&db=m Polycystic liver disease: ductal plate malformation and the primary cilium. causal interaction,unassigned 1,0 2.7.11.13 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18370676&form=6&db=m Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Polycythemia Vera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9112425&form=6&db=m Possible involvement of protein kinase C in the aberrant regulation of erythropoiesis in polycythemia vera. ongoing research,unassigned 4,0 2.7.11.13 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187767&form=6&db=m [Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology] causal interaction,unassigned 3,0 2.7.11.13 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29522984&form=6&db=m Porcine reproductive and respiratory syndrome virus induces HMGB1 secretion via activating PKC-delta to trigger inflammatory response. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9734941&form=6&db=m Endothelial-cell permeability and protein kinase C in pre-eclampsia. unassigned - 2.7.11.13 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18472156&form=6&db=m PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26350097&form=6&db=m Mechanism of agonistic angiotensin II type I receptor autoantibody-amplified contractile response to Ang II in the isolated rat thoracic aorta. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27891249&form=6&db=m Protein Kinase C Epsilon Contributes to NADPH Oxidase Activation in a Pre-Eclampsia Lymphoblast Cell Model. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32544612&form=6&db=m The Inhibition of Protein Kinase C ? Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy. causal interaction,unassigned 2,0 2.7.11.13 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2673548&form=6&db=m Expression of CD9 antigen on normal activated human B cells. causal interaction,unassigned 3,0 2.7.11.13 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630457&form=6&db=m Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1283964&form=6&db=m Activated protein kinase C directly phosphorylates the CD34 antigen in acute lymphoblastic leukemia cells. diagnostic usage,unassigned 3,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1824824&form=6&db=m Protein kinase C activity and multidrug resistance in MOLT-3 human lymphoblastic leukemia cells resistant to trimetrexate. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1868447&form=6&db=m Expression of three major protein kinase C isozymes in various types of human leukemic cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2733239&form=6&db=m Effect of an inhibitory factor for protein kinase C on cell growth of leukemic cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2787455&form=6&db=m Induction of tumoricidal activity and alterations of growth by interleukin-2 and manipulation of protein kinase C and cytosolic calcium in childhood acute lymphocytic leukemia cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8986147&form=6&db=m Prognostic value of protein kinase C, proto-oncogene products and resistance-related proteins in newly diagnosed childhood acute lymphoblastic leukemia. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10037185&form=6&db=m A requirement for protein kinase C inhibition for calcium-triggered apoptosis in acute lymphoblastic leukemia cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14737078&form=6&db=m PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630457&form=6&db=m Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566933&form=6&db=m Prognostic-significance of protein-kinase-C in newly-diagnosed childhood acute lymphoblastic-leukemia. diagnostic usage,unassigned 4,0 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23086478&form=6&db=m NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-? and reactive oxygen species. unassigned - 2.7.11.13 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693686&form=6&db=m Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509123&form=6&db=m Anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase C isozymes in the T-lymphoblastoid cell line CCRF-CEM and in blasts from patients with acute lymphoblastic leukemias. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Presbycusis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21056652&form=6&db=m Age-related increase in PKC gamma expression in the cochlear nucleus of hearing impaired C57BL/6J and BALB/c mice. causal interaction,unassigned 3,0 2.7.11.13 Primary Myelofibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2242424&form=6&db=m Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. unassigned - 2.7.11.13 Primary Myelofibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28758099&form=6&db=m Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Prolactinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8097303&form=6&db=m Immunohistochemical expression of protein kinase C type III in human pituitary adenomas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Prolactinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32357622&form=6&db=m Hybridization studies of cultured human pituitary prl and gh producing adenoma cells: Effects of thyrotropin-releasing hormone, somatostatin, and phorbol ester. diagnostic usage,unassigned 3,0 2.7.11.13 Prostatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719062&form=6&db=m Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719062&form=6&db=m Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145232&form=6&db=m Distribution of Thyroliberin (TRH)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-activated adenylyl cyclase in normal and neoplastic tissue with special reference to the prostate. causal interaction,unassigned 4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7518003&form=6&db=m 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7954449&form=6&db=m c-fos promoter insensitivity to phorbol ester and possible role of protein kinase C in androgen-independent cancer cells. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797581&form=6&db=m Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8895766&form=6&db=m Human prostate carcinoma cells express functional alphaIIb(beta)3 integrin. unassigned - 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9052983&form=6&db=m Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9099897&form=6&db=m Prolactin regulation of mitochondrial aspartate aminotransferase and protein kinase C in human prostate cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9348191&form=6&db=m Transforming growth factor-beta1 inhibits membrane association of protein kinase C alpha in a human prostate cancer cell line, PC3. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514905&form=6&db=m The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen-independent human prostatic cancer cells. ongoing research,unassigned 3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547622&form=6&db=m 12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9605775&form=6&db=m 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721069&form=6&db=m Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21(waf1/cip1). causal interaction,unassigned 4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9916928&form=6&db=m Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499606&form=6&db=m A Phase II study of high-dose tamoxifen in patients with hormone-refractory prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10713064&form=6&db=m Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779634&form=6&db=m Induction of KAI-1 expression in metastatic cancer cells by phorbol esters. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825394&form=6&db=m Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha. ongoing research,unassigned 3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11118039&form=6&db=m Neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells by inhibiting neuropeptide-induced protein kinase C delta degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11337282&form=6&db=m RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350056&form=6&db=m Fatty acid regulation of protein kinase C isoforms in prostate cancer cells. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584014&form=6&db=m Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. therapeutic application,unassigned 1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723237&form=6&db=m Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11747987&form=6&db=m Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11901191&form=6&db=m Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. causal interaction,unassigned 3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11913958&form=6&db=m Protein kinase C pathway is involved in regulating the secretion of prostatic acid phosphatase in human prostate cancer cells. causal interaction,unassigned 3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956106&form=6&db=m Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12171880&form=6&db=m A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12185081&form=6&db=m Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12497586&form=6&db=m Ribozyme-mediated inhibition of PKCalpha sensitizes androgen-independent human prostate cancer cells to cisplatin-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616719&form=6&db=m Manipulating expression of endogenous oncogenic proteins using an antisense oligonucleotide approach in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824193&form=6&db=m Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12859948&form=6&db=m Protein kinase C mu is down-regulated in androgen-independent prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970744&form=6&db=m Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734478&form=6&db=m Chemosensitization of androgen-independent prostate cancer with neutral endopeptidase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739659&form=6&db=m Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138488&form=6&db=m JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142167&form=6&db=m Protein kinase C-alpha in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15174974&form=6&db=m Antisense approaches in prostate cancer. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15216909&form=6&db=m Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252138&form=6&db=m Down-regulation of protein kinase Ceta potentiates the cytotoxic effects of exogenous tumor necrosis factor-related apoptosis-inducing ligand in PC-3 prostate cancer cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456642&form=6&db=m Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467757&form=6&db=m Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499829&form=6&db=m Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542774&form=6&db=m Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15837784&form=6&db=m Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897236&form=6&db=m Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111875&form=6&db=m Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183650&form=6&db=m Phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade: a key role for protein kinase C delta. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184549&form=6&db=m Overexpression of PKCepsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394101&form=6&db=m Protein Kinase C{gamma} Regulates Myosin IIB Phosphorylation, Cellular Localization, and Filament Assembly. therapeutic application,unassigned 1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979586&form=6&db=m Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCalpha. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,2 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875724&form=6&db=m Protein Kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006831&form=6&db=m PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18313772&form=6&db=m Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18637986&form=6&db=m Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance. unassigned - 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701509&form=6&db=m Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922790&form=6&db=m Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029835&form=6&db=m PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19127120&form=6&db=m Ceramide-mediated apoptosis following ionizing radiation in human prostate cancer cells: PKCalpha joins the fray. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19302977&form=6&db=m MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19713972&form=6&db=m Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. causal interaction,unassigned 4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903468&form=6&db=m Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20102325&form=6&db=m Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20203103&form=6&db=m Activation of Rac1 is closely related to androgen-independent cell proliferation of prostate cancer cells both in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20369375&form=6&db=m Oral enzastaurin in prostate cancer: A two-cohort phase II trial in patients with PSA progression in the non-metastatic castrate state and following docetaxel-based chemotherapy for castrate metastatic disease. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20516369&form=6&db=m Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. therapeutic application,unassigned 1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20566643&form=6&db=m Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21132068&form=6&db=m Differential Sensitization of Different Prostate Cancer Cells to Apoptosis. therapeutic application,unassigned 2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21266973&form=6&db=m Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21406403&form=6&db=m Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21535317&form=6&db=m Coexpression of aPKC?/? and IL-6 in prostate cancer tissue correlates with biochemical recurrence. causal interaction,unassigned 4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779455&form=6&db=m PRKC-? Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21824498&form=6&db=m Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22644296&form=6&db=m Splice variant PRKC-?(-PrC) is a novel biomarker of human prostate cancer. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22955280&form=6&db=m Activation of Nuclear Factor-Kappa B (NF?B) in Prostate Cancer is Mediated by PKC Epsilon (PKC{epsilon}). unassigned - 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435622&form=6&db=m A randomized, double-blind, placebo-controlled, Phase II study with and without enzastaurin in combination with docetaxel-based chemotherapy in patients with castration-resistant metastatic prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24113377&form=6&db=m Lysophosphatidic acid induces reactive oxygen species generation by activating protein kinase C in PC-3 human prostate cancer cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352647&form=6&db=m Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24377786&form=6&db=m Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281873&form=6&db=m Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25797625&form=6&db=m Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. therapeutic application,unassigned 1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26023164&form=6&db=m PKC? Is an Essential Mediator of Prostate Cancer Bone Metastasis. ongoing research,unassigned 3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28223364&form=6&db=m Protein kinase C regulates Twist1 expression via NF-?B in prostate cancer. diagnostic usage,unassigned 2,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28631559&form=6&db=m PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28697177&form=6&db=m The TGF-? signalling negative regulator PICK1 represses prostate cancer metastasis to bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28875501&form=6&db=m The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29744295&form=6&db=m Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,3 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30209539&form=6&db=m Crosstalk of protein kinase C ? with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30705401&form=6&db=m PKC? facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model. causal interaction,diagnostic usage,unassigned 3,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516713&form=6&db=m Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32427575&form=6&db=m A novel 3',5'-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKC?/JNK signal in prostate cancer. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33321758&form=6&db=m Liposomes Targeting P21 Activated Kinase-1 (PAK-1) and Selective for Secretory Phospholipase A2 (sPLA2) Decrease Cell Viability and Induce Apoptosis in Metastatic Triple-Negative Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.13 Protein Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8781028&form=6&db=m Effect of dietary protein manipulation on translocation of protein kinase C activity in various tissues of rats. causal interaction,unassigned 1,0 2.7.11.13 Protein Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9475078&form=6&db=m Dietary protein deficiency induced changes in protein kinase C activity and phospholipid metabolism in rat hepatocytes. causal interaction,unassigned 3,0 2.7.11.13 Protein Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082765&form=6&db=m Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice. ongoing research,unassigned 1,0 2.7.11.13 Protein Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053266&form=6&db=m Phospholipid metabolism and protein kinase C mediated protein phosphorylation in dietary protein deficiency in rat lung. ongoing research,unassigned 1,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2608443&form=6&db=m Protein kinase C deficiency in juvenile chronic myeloid leukemia: a case report. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3331710&form=6&db=m Insulin action in normal and protein kinase C-deficient rat hepatoma cells. Effects on protein phosphorylation, protein kinase activities, and ornithine decarboxylase activities and messenger ribonucleic acid levels. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702931&form=6&db=m Protein kinase C deficiency blocks recovery from agonist-induced desensitization. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277208&form=6&db=m Loss of PKC-delta alters cardiac metabolism. unassigned - 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962198&form=6&db=m Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18031696&form=6&db=m The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction. unassigned - 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18263766&form=6&db=m Natural killer cells from protein kinase C theta-/- mice stimulated with interleukin-12 are deficient in production of interferon-gamma. unassigned - 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258705&form=6&db=m PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19296465&form=6&db=m Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620996&form=6&db=m PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23630453&form=6&db=m PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23630454&form=6&db=m PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233929&form=6&db=m Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27537764&form=6&db=m PICK1 Regulates the Expression and Trafficking of AMPA Receptors in Remifentanil-Induced Hyperalgesia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28783756&form=6&db=m PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis. unassigned - 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29471107&form=6&db=m PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT. causal interaction,unassigned 4,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402043&form=6&db=m PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307672&form=6&db=m PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury. causal interaction,unassigned 4,0 2.7.11.13 protein kinase c deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34500285&form=6&db=m The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Protein-Energy Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082765&form=6&db=m Expression of T lymphocyte p56(lck), a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice. ongoing research,unassigned 1,0 2.7.11.13 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8727709&form=6&db=m Capacity of H2O2 release from monocytes in steroid-sensitive nephrotic syndrome. therapeutic application,unassigned 1,0 2.7.11.13 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11576956&form=6&db=m Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. causal interaction,unassigned 3,0 2.7.11.13 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758661&form=6&db=m Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21321125&form=6&db=m PKC{alpha} Mediates {beta}-Arrestin2-dependent Nephrin Endocytosis in Hyperglycemia. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23434935&form=6&db=m Dual Inhibition of Classical Protein Kinase C-? and Protein Kinase C-? Isoforms Protects Against Experimental Murine Diabetic Nephropathy. causal interaction,unassigned 3,0 2.7.11.13 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105215&form=6&db=m Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1. ongoing research,unassigned 2,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1431218&form=6&db=m Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiation. unassigned - 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2064937&form=6&db=m Protein kinase C activity in normal and psoriatic cells: cultures of fibroblasts and lymphocytes. ongoing research,unassigned 4,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170539&form=6&db=m Increased phospholipase C-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate and 1,2-sn-diacylglycerol content in psoriatic involved compared to uninvolved and normal epidermis. causal interaction,unassigned 3,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3805758&form=6&db=m Decreased protein kinase C activity in psoriatic versus normal epidermis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547380&form=6&db=m Down-regulation of Langerhans cell protein kinase C-beta isoenzyme expression in inflammatory and hyperplastic dermatoses. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245514&form=6&db=m Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8409523&form=6&db=m Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-beta II in psoriasis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8409524&form=6&db=m Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis. unassigned - 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8505157&form=6&db=m Psoriasis, involucrin, and protein kinase C. unassigned - 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9341975&form=6&db=m SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928424&form=6&db=m Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways. therapeutic application,unassigned 2,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16479073&form=6&db=m Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-alpha, and JNK. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982236&form=6&db=m A study on altered expression of serine palmitoyltransferase and ceramidase in psoriatic skin lesion. causal interaction,unassigned 3,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385757&form=6&db=m Activation of keratinocyte protein kinase C zeta in psoriasis plaques. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19876790&form=6&db=m Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis. therapeutic application,unassigned 4,0 2.7.11.13 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26255795&form=6&db=m Small Molecules in the Treatment of Psoriasis. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420332&form=6&db=m Expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts is increased with disease progression and activation of protein kinase C. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12435298&form=6&db=m The effect of extracellular matrix remodeling on airflow obstruction in a rat model of chronic obstructive pulmonary disease. ongoing research,unassigned 4,0 2.7.11.13 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15631829&form=6&db=m [Expression of protein kinase C and nuclear factor kappa B in lung tissue of patients with chronic obstructive pulmonary disease.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20407865&form=6&db=m Changes of protein kinase Calpha and cyclin D1 expressions in pulmonary arteries from smokers with and without chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.13 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21527308&form=6&db=m Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23221047&form=6&db=m A Myristoylated Alanine-Rich C Kinase Substrate-Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27516147&form=6&db=m Pharmacological inhibition of protein kinase C (PKC)? downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). causal interaction,unassigned 4,0 2.7.11.13 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573983&form=6&db=m Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0 2.7.11.13 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987411&form=6&db=m Endothelin antagonists: new bullets against lung injury? unassigned - 2.7.11.13 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15133032&form=6&db=m Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. causal interaction,unassigned 4,0 2.7.11.13 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29633755&form=6&db=m Interleukin (IL)-13, Prostaglandin E2 (PGE2), and Prostacyclin 2 (PGI2) Activate Hepatic Stellate Cells via Protein kinase C (PKC) Pathway in Hepatic Fibrosis. causal interaction,unassigned 2,0 2.7.11.13 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32390869&form=6&db=m Protein Kinase C ? (PKC?) Attenuates Bleomycin Induced Pulmonary Fibrosis via Inhibiting NF-?B Signaling Pathway. causal interaction,unassigned 3,0 2.7.11.13 Purpura, Thrombocytopenic, Idiopathic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16212887&form=6&db=m Effect of protein kinase C on proliferation and apoptosis of T lymphocytes in idiopathic thrombocytopenic purpura children. unassigned - 2.7.11.13 Purpura, Thrombocytopenic, Idiopathic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16624065&form=6&db=m [Analysis of protein kinase C activity of peripheral blood T lymphocytes in children with acute idiopathic thrombocytopenic purpura] diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Purpura, Thrombocytopenic, Idiopathic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016035&form=6&db=m Effect of protein kinase C on T lymphocyte proliferation and apoptosis in acute idiopathic thrombocytopenic purpura. ongoing research,unassigned 1,0 2.7.11.13 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10590095&form=6&db=m The phosphoprotein of rabies virus is phosphorylated by a unique cellular protein kinase and specific isomers of protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758661&form=6&db=m Evaluation of renal gene expression of protein kinase C (PKC) isoforms in diabetic and nondiabetic proliferative glomerular diseases. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.13 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31942834&form=6&db=m Investigation of the effects of indoxyl sulfate, a uremic toxin, on the intracellular oxidation level and phagocytic activity using an HL-60-differentiated human macrophage cell model. unassigned - 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2917008&form=6&db=m Improvement of ischemia-reperfusion-induced myocardial dysfunction by modulating calcium-overload using a novel, specific calmodulin antagonist, CGS 9343B. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8800168&form=6&db=m Cardiac preconditioning with calcium: clinically accessible myocardial protection. therapeutic application,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8853396&form=6&db=m Protein kinase C mediates Ca2(+)-induced cardioadaptation to ischemia-reperfusion injury. causal interaction,unassigned 2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9441840&form=6&db=m Effects of protein kinase C inhibitors in in situ and isolated ischemic rabbit myocardium. ongoing research,unassigned 2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9564929&form=6&db=m Calcium preconditioning in human myocardium. causal interaction,unassigned 4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9653175&form=6&db=m Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10536671&form=6&db=m Pretreatment with PKC activator protects cardiomyocytes against reoxygenation-induced hypercontracture independently of Ca2+ overload. causal interaction,unassigned 4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10603424&form=6&db=m Protein kinase C inhibitors abolish the increased resistance of diabetic rat heart to ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11271195&form=6&db=m SPC-100270, a protein kinase C inhibitor, reduced hypoxic injury due to reperfusion following orthotopic liver transplantation in the rat. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559003&form=6&db=m Protein kinase C-epsilon is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures. unassigned - 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529578&form=6&db=m Differential activation of protein kinase C between ischemic and pharmacological preconditioning in the rabbit heart. therapeutic application,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597593&form=6&db=m Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. therapeutic application,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15165841&form=6&db=m Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15192771&form=6&db=m Protein kinase C and myocardial calcium handling during ischemia and reperfusion: lessons learned using Rhod-2 spectrofluorometry. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15295022&form=6&db=m Protein kinase C delta mediates cerebral reperfusion injury in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716854&form=6&db=m Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15792991&form=6&db=m Protein kinase C-zeta inhibition exerts cardioprotective effects in ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867794&form=6&db=m Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15946993&form=6&db=m Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16254221&form=6&db=m The role of protein kinase C in cerebral ischemic and reperfusion injury. causal interaction,unassigned 4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17577736&form=6&db=m Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway. therapeutic application,unassigned 2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17692311&form=6&db=m Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. therapeutic application,unassigned 3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17825316&form=6&db=m deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart. causal interaction,unassigned 3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18155566&form=6&db=m Cardiopulmonary bypass with cardioplegic arrest activates protein kinase C in the human myocardium. causal interaction,unassigned 3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408135&form=6&db=m Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition. causal interaction,unassigned 2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18586397&form=6&db=m epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury. causal interaction,unassigned 3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18668351&form=6&db=m Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18983847&form=6&db=m Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19026571&form=6&db=m Unresolved issues in myocardial reperfusion injury. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19240739&form=6&db=m Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470841&form=6&db=m Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: role of protein kinase C epsilon. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19538969&form=6&db=m Direct effect of cocaine on epigenetic regulation of PKCepsilon gene repression in the fetal rat heart. unassigned - 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19674116&form=6&db=m Molecular aspects of ischaemic postconditioning. unassigned - 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725910&form=6&db=m Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation. unassigned - 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20538683&form=6&db=m Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts. causal interaction,unassigned 4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20558438&form=6&db=m Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20629316&form=6&db=m [Role of protein kinase C in protecting rats against pulmonary ischemia reperfusion injury through opening of mitochondrial ATP sensitive potassium channel] causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712587&form=6&db=m Hypoxia and fetal heart development. causal interaction,unassigned 4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20733009&form=6&db=m Foetal nicotine exposure causes PKC{varepsilon} gene repression by promoter methylation in rat hearts. causal interaction,unassigned 4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21318404&form=6&db=m Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood-Brain Barrier in a Focal Cerebral Ischemic Insult. therapeutic application,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21378031&form=6&db=m Platelet activating factor: the good and the bad in the ischemic/reperfused heart. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21592890&form=6&db=m Myocardial postconditioning: anaesthetic considerations. causal interaction,unassigned 4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21865497&form=6&db=m Limb Remote Postconditioning Alleviates Cerebral Reperfusion Injury Through Reactive Oxygen Species-Mediated Inhibition of Delta Protein Kinase C in Rats. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21883905&form=6&db=m Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation. therapeutic application,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22537485&form=6&db=m Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphtidylinositol 3'-kinase - Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22932117&form=6&db=m Protein Kinase C Inhibition Ameliorates Posttransplantation Preservation Injury in Rat Renal Transplants. causal interaction,unassigned 2,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23140054&form=6&db=m [Effect of electroacupuncture on cerebral PKC isozyme expression levels in cerebral ischemia-reperfusion rats]. unassigned - 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496955&form=6&db=m The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKC? unassigned - 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24722289&form=6&db=m Selective inhibition of protein kinase C ?2 attenuates the adaptor P66(Shc)-mediated intestinal ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505750&form=6&db=m Sevoflurane Preconditioning Reduces Intestinal Ischemia-Reperfusion Injury: Role of Protein Kinase C and Mitochondrial ATP-Sensitive Potassium Channel. causal interaction,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27092987&form=6&db=m The role of Akt (protein kinase B) and protein kinase C in ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27771708&form=6&db=m Morphine Postconditioning Protects Against Reperfusion Injury: the Role of Protein Kinase C-Epsilon, Extracellular Signal-Regulated Kinase 1/2 and Mitochondrial Permeability Transition Pores. therapeutic application,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580718&form=6&db=m Loss of Ribosomal RACK1 (Receptor for Activated Protein Kinase C 1) Induced by Phosphorylation at T50 Alleviates Cerebral Ischemia-Reperfusion Injury in Rats. causal interaction,unassigned 1,0 2.7.11.13 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31541352&form=6&db=m PKC? and PKC? are Differentially Activated and Modulate Neurotoxic Signaling Pathways During Oxygen Glucose Deprivation in Rat Cortical Slices. causal interaction,unassigned 4,0 2.7.11.13 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23572089&form=6&db=m Protein kinase C and acute respiratory distress syndrome. causal interaction,diagnostic usage,unassigned 3,2,0 2.7.11.13 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228806&form=6&db=m Activation of Protein Kinase C (PKC)? or PKC{varepsilon} as an Approach to Increase Morphine Tolerance in Respiratory Depression and Lethal Overdose. unassigned - 2.7.11.13 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28130265&form=6&db=m Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29574756&form=6&db=m Oxycodone-induced Tolerance to Respiratory Depression: Reversal by Ethanol, Pregabalin, and Protein Kinase C Inhibition. therapeutic application,unassigned 1,0 2.7.11.13 Respiratory Syncytial Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160332&form=6&db=m Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. causal interaction,unassigned 4,0 2.7.11.13 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1962207&form=6&db=m Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C. unassigned - 2.7.11.13 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9737715&form=6&db=m Altered regulation of L-type channels by protein kinase C and protein tyrosine kinases as a pathophysiologic effect in retinal degeneration. ongoing research,unassigned 4,0 2.7.11.13 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17207538&form=6&db=m Protein kinase C-zeta mediates retinal degeneration in response to TNF. therapeutic application,unassigned 1,0 2.7.11.13 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25781645&form=6&db=m The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control. unassigned - 2.7.11.13 Retinal Detachment http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26978024&form=6&db=m Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, ?. therapeutic application,unassigned 1,0 2.7.11.13 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10362799&form=6&db=m Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.13 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11805327&form=6&db=m Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. ongoing research,unassigned 3,0 2.7.11.13 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825373&form=6&db=m Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Retinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12867066&form=6&db=m Antisense oligonucleotides for cancer therapy-an overview. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1564629&form=6&db=m Pineal and retinal protein kinase C isoenzymes: cooperative activation by calcium and zinc metallothionein. unassigned - 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8280742&form=6&db=m Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. causal interaction,unassigned 3,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662781&form=6&db=m Ceramide inactivates cellular protein kinase Calpha. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9083081&form=6&db=m Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9204767&form=6&db=m Death substrates come alive. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9278434&form=6&db=m Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10507539&form=6&db=m Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells. ongoing research,unassigned 3,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11041200&form=6&db=m Okadaic acid suppresses TPA-induced differentiation by stimulating G1/S transition in human myeloblastic leukaemia ML-1 cells. ongoing research,unassigned 4,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11480555&form=6&db=m Ceramide regulates cellular homeostasis via diverse stress signaling pathways. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11805327&form=6&db=m Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. ongoing research,unassigned 3,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889133&form=6&db=m The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis. unassigned - 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12734388&form=6&db=m Mediation of corticotropin releasing factor type 1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation. ongoing research,unassigned 4,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14653808&form=6&db=m The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996929&form=6&db=m Proteins that bind A-type lamins: integrating isolated clues. unassigned - 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949478&form=6&db=m PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. therapeutic application,unassigned 2,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17239975&form=6&db=m Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein. therapeutic application,unassigned 1,0 2.7.11.13 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24525074&form=6&db=m Regulation of the cancer cell membrane lipid composition by NaCHOleate: Effects on cell signaling and therapeutical relevance in glioma. unassigned - 2.7.11.13 Retinopathy of Prematurity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29957984&form=6&db=m Pharmacological Interventions for Vascular Targeting in Retinopathy of Prematurity: An Experimental Study. therapeutic application,unassigned 1,0 2.7.11.13 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7547506&form=6&db=m Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells. ongoing research,unassigned 3,0 2.7.11.13 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349825&form=6&db=m Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22426323&form=6&db=m Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC). ongoing research,unassigned 4,0 2.7.11.13 Rhabdomyosarcoma, Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17585318&form=6&db=m Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Rhabdomyosarcoma, Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22349825&form=6&db=m Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Rhabdomyosarcoma, Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28590507&form=6&db=m Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.7.11.13 Rhabdomyosarcoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12186945&form=6&db=m PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.13 Rhabdomyosarcoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17585318&form=6&db=m Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Rheumatic Heart Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34482802&form=6&db=m Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease. unassigned - 2.7.11.13 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17438848&form=6&db=m [The role of protein kinase C and activator protein-1 signal cascade in the regulation of expression of interleukin-5 in T lymphocyte of allergic rhinitis] diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.13 Rift Valley Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21124804&form=6&db=m Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21934108&form=6&db=m Phosphoproteomic analysis of Salmonella-infected cells identifies key kinase regulators and SopB-dependent host phosphorylation events. causal interaction,unassigned 1,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2168030&form=6&db=m Evidence for involvement of the protein kinase C pathway in the activation of p37v-mos protein kinase. ongoing research,unassigned 2,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6283546&form=6&db=m Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase. ongoing research,unassigned 1,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188761&form=6&db=m Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9201277&form=6&db=m In vitro and in vivo studies of murine sarcoma cells after prolonged treatment with promoting phorbol ester TPA. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9535822&form=6&db=m Induction of apoptosis by hepatocyte growth factor/scatter factor and its augmentation by phorbol esters in Meth A cells. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771283&form=6&db=m Involvement of protein kinase C in taxol-induced polyploidization in a cultured sarcoma cell line. ongoing research,unassigned 3,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217944&form=6&db=m Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16528479&form=6&db=m A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial. ongoing research,unassigned 2,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18343476&form=6&db=m Walleye dermal sarcoma virus Orf B functions through receptor for activated C kinase (RACK1) and protein kinase C. therapeutic application,unassigned 2,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18507025&form=6&db=m Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18756024&form=6&db=m Letter: correlation between phosphorylation ratios by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis and enzyme kinetics. ongoing research,unassigned 2,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19578554&form=6&db=m Expression of muscarinic receptors in human and mouse sclera and their role in the regulation of scleral fibroblasts proliferation. ongoing research,unassigned 1,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716168&form=6&db=m DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21071245&form=6&db=m Chromosomal localisation and genetic variation of the SLC11A1 gene in goats (Capra hircus). unassigned - 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21625473&form=6&db=m A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells. unassigned - 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22157653&form=6&db=m Endosome-mediated retrograde axonal transport of P2X(3) receptor signals in primary sensory neurons. unassigned - 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22157681&form=6&db=m EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. causal interaction,unassigned 1,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23645742&form=6&db=m Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-?B and matrix metalloproteinase-2/-9 signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25453364&form=6&db=m Targeting protein kinase C in sarcoma. unassigned - 2.7.11.13 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930073&form=6&db=m Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes. unassigned - 2.7.11.13 Sarcoma 180 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2819714&form=6&db=m Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Sarcoma 180 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8102593&form=6&db=m Reversal of doxorubicin-resistance in sarcoma 180 tumor cells by inhibition of different resistance mechanisms. therapeutic application,unassigned 1,0 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=52872&form=6&db=m Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1531537&form=6&db=m Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes. unassigned - 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158036&form=6&db=m The oncogenic protein p60v-src has competence activity but does not activate phosphatidylinositol turnover or protein kinase C in Balb/c 3T3 cells. unassigned - 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2944513&form=6&db=m Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses. causal interaction,unassigned 1,0 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038883&form=6&db=m Regulation of protein kinase C by cyclic adenosine 3':5'-monophosphate and a tumor promoter in skeletal myoblasts. ongoing research,unassigned 1,0 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6281757&form=6&db=m Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892618&form=6&db=m Molecularly targeted therapy for gastrointestinal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23285258&form=6&db=m Characterization of the Phosphoproteome in SLE Patients. unassigned - 2.7.11.13 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23660595&form=6&db=m Chaperone properties of pdia3 participate in rapid membrane actions of 1?,25-dihydroxyvitamin d3. unassigned - 2.7.11.13 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521081&form=6&db=m Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19609943&form=6&db=m Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKCalpha phosphorylation. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11696585&form=6&db=m Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. ongoing research,unassigned 4,0 2.7.11.13 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22096525&form=6&db=m Effect of protein kinase C delta (PKC-?) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. ongoing research,unassigned 4,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1308196&form=6&db=m Amygdala kindling-induced seizures selectively impair spatial memory. 1. Behavioral characteristics and effects on hippocampal neuronal protein kinase C isoforms. ongoing research,unassigned 2,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331919&form=6&db=m Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1458321&form=6&db=m Enduring increase in membrane-associated protein kinase C activity in the hippocampal-kindled rat. ongoing research,unassigned 2,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1662304&form=6&db=m Long-lasting enhancement of the membrane-associated protein kinase C activity in the hippocampal kindled rat. therapeutic application,unassigned 1,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1735474&form=6&db=m Protein kinase C activity and subcellular distribution in rat brain following repeated electroconvulsive seizures. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7633882&form=6&db=m Long-lasting increase in protein kinase C activity in the hippocampus of amygdala-kindled rat. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7825186&form=6&db=m A hypothesis for cyanide-induced tonic seizures with supporting evidence. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7827999&form=6&db=m Differential changes in the activities of multiple protein kinase C subspecies in the hippocampal-kindled rat. ongoing research,unassigned 2,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7922528&form=6&db=m Alterations of protein kinase C isozyme and substrate proteins in mouse brain after electroconvulsive seizures. unassigned - 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8082633&form=6&db=m Kindled amygdaloid seizures in rats cause immediate and transient increase in protein kinase C activity followed by transient suppression of the activity. unassigned - 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9387878&form=6&db=m Selective up-regulation of protein kinase C epsilon in granule cells after kainic acid-induced seizures in rat. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10098884&form=6&db=m Differential subcellular redistribution of protein kinase C isozymes in the rat hippocampus induced by kainic acid. unassigned - 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11054811&form=6&db=m Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization. ongoing research,unassigned 3,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311798&form=6&db=m Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-epsilon. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12372903&form=6&db=m Excitatory amino acid-elicited tonic convulsions in mice and N-methyl-D-aspartate receptor activation: role of Ca(2+) influx and involvement of intracellular Ca(2+)-dependent biochemical processes. therapeutic application,unassigned 1,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573517&form=6&db=m Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice. therapeutic application,unassigned 2,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15128407&form=6&db=m Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. unassigned - 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16819290&form=6&db=m Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18596877&form=6&db=m Impact of protein kinase C activation on status epilepticus and epileptogenesis: oh, what a tangled web. therapeutic application,unassigned 1,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18641645&form=6&db=m PICK1 uncoupling from mGluR7a causes absence-like seizures. ongoing research,unassigned 1,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19837121&form=6&db=m Electroconvulsive seizure increases phosphorylation of PKC substrates, including GAP-43, MARCKS, and neurogranin, in rat brain. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24952362&form=6&db=m The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Seizures, Febrile http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31321958&form=6&db=m Protein kinase C-? contributes to a chronic inhibitory effect of IL-1? on voltage-gated sodium channels in mice with febrile seizure. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1858953&form=6&db=m Antagonism of endotoxic glucose dyshomeostasis by protein kinase C inhibitors. unassigned - 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839308&form=6&db=m Alterations in bidirectional transmembrane calcium flux occur without changes in protein kinase C levels in rat aorta during sepsis. ongoing research,unassigned 1,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2928368&form=6&db=m Alterations in splenic and hepatic protein kinase C in sepsis and chronic endotoxemia. unassigned - 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8151110&form=6&db=m Modulation of protein kinase C alters hemodynamics and metabolism in the isolated liver in fed and fasted rats. causal interaction,unassigned 3,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8467175&form=6&db=m K252a, a potent protein kinase inhibitor, improves endotoxic lethality and glucose dyshomeostasis. causal interaction,unassigned 4,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202648&form=6&db=m Chronic septicemia alters alpha-adrenergic mechanisms in the coronary circulation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9389165&form=6&db=m [Changes in the calcium channels in rat cardiac cells during sepsis] unassigned - 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9525325&form=6&db=m Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis. therapeutic application,unassigned 1,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9525327&form=6&db=m Protein kinase C activity is increased in rat heart during the early hyperdynamic phase of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9562254&form=6&db=m Inactivation of protein kinase C in rat liver during late hypoglycemic phase of sepsis. ongoing research,unassigned 4,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11220641&form=6&db=m The decrease of PKCalpha is associated with hepatic apoptosis at early and late phases of polymicrobial sepsis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11775202&form=6&db=m Alternation of Na(+)-Ca2+ exchange in rat cardiac sarcolemmal membranes during different phases of sepsis. therapeutic application,unassigned 2,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795668&form=6&db=m Alteration of protein kinase C isoforms in the liver of septic rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11990934&form=6&db=m Complement activation alters myocellular sodium homeostasis during polymicrobial sepsis. ongoing research,unassigned 4,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12022753&form=6&db=m Monocyte deactivation in severe human sepsis or following cardiopulmonary bypass. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12785016&form=6&db=m Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line. causal interaction,unassigned 1,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15149857&form=6&db=m The essential role of PKCalpha in the protective effect of heat-shock pretreatment on TNFalpha-induced apoptosis in hepatic epithelial cell line. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15278495&form=6&db=m Modification of hepatic protein kinase C with phorbol myristate acetate and staurosporine alters hemodynamics in the perfused rat liver. causal interaction,unassigned 3,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15814724&form=6&db=m Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis. causal interaction,unassigned 4,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205321&form=6&db=m Role of cAMP-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase C alpha suppression during sepsis. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17325208&form=6&db=m PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17899301&form=6&db=m Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26375024&form=6&db=m PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis. unassigned - 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27190303&form=6&db=m A novel microfluidic assay reveals a key role for protein kinase C ? in regulating human neutrophil-endothelium interaction. therapeutic application,unassigned 1,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29617417&form=6&db=m Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402043&form=6&db=m PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31908004&form=6&db=m Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32985287&form=6&db=m Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 2.7.11.13 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34500285&form=6&db=m The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Sepsis-Associated Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34500285&form=6&db=m The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156256&form=6&db=m The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2192814&form=6&db=m Unexpected hyperactivity of myocardial adenylate cyclase system in endotoxic male rats. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830336&form=6&db=m Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells. ongoing research,unassigned 2,0 2.7.11.13 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30524682&form=6&db=m Effects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways. ongoing research,unassigned 4,0 2.7.11.13 Sialic Acid Storage Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19426133&form=6&db=m Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis. unassigned - 2.7.11.13 Situs Inversus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8150214&form=6&db=m Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7700990&form=6&db=m Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica. therapeutic application,unassigned 1,0 2.7.11.13 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245514&form=6&db=m Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8661342&form=6&db=m Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. therapeutic application,unassigned 2,0 2.7.11.13 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9341975&form=6&db=m SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15109560&form=6&db=m Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms. unassigned - 2.7.11.13 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1431218&form=6&db=m Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiation. unassigned - 2.7.11.13 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057036&form=6&db=m The role of protein kinase C-alpha (PKC-alpha) in melanoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15109560&form=6&db=m Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms. unassigned - 2.7.11.13 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516713&form=6&db=m Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.13 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7583240&form=6&db=m Sleep deprivation differentially alters the mRNA and protein levels of neurogranin in rat brain. unassigned - 2.7.11.13 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22070228&form=6&db=m Successful combined therapy with tamoxifen and lithium in a paradoxical sleep deprivation-induced mania model. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25577667&form=6&db=m Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania. unassigned - 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309802&form=6&db=m Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma cell line. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329908&form=6&db=m Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1655253&form=6&db=m c-myc gene-induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation. ongoing research,unassigned 4,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8262160&form=6&db=m Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells. unassigned - 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8720314&form=6&db=m Effects of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930400&form=6&db=m Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9019168&form=6&db=m Properties of classic protein kinase C in human small cell lung carcinoma NCI-H345 cells. ongoing research,unassigned 4,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9205066&form=6&db=m Cholera toxin triggers apoptosis in human lung cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,2 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9743176&form=6&db=m Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma. unassigned - 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9973202&form=6&db=m Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121973&form=6&db=m Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15382037&form=6&db=m Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling. causal interaction,unassigned 3,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705582&form=6&db=m Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. causal interaction,unassigned 1,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16810323&form=6&db=m FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. ongoing research,unassigned 2,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17273774&form=6&db=m Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525161&form=6&db=m Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation. causal interaction,unassigned 3,0 2.7.11.13 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18401527&form=6&db=m Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 small monomeric gtpase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33679729&form=6&db=m The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria. causal interaction,unassigned 4,0 2.7.11.13 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8674178&form=6&db=m Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo. ongoing research,unassigned 2,0 2.7.11.13 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651199&form=6&db=m Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models. causal interaction,unassigned 1,0 2.7.11.13 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657973&form=6&db=m Cerebral vasospasm after subarachnoid hemorrhage. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12739235&form=6&db=m Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.13 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16529545&form=6&db=m Cardiotoxicity of 5-Fluorouracil. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27534449&form=6&db=m Upregulations of CRH and CRHR1 in the Epileptogenic Tissues of Patients with Intractable Infantile Spasms. causal interaction,diagnostic usage,unassigned 1,2,0 2.7.11.13 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276002&form=6&db=m Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina. therapeutic application,unassigned 1,0 2.7.11.13 Sphingolipidoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3101176&form=6&db=m Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Sphingolipidoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8347687&form=6&db=m Inhibition of protein kinase C activity in mucolipidosis type-4: a model for a new pathogenetic mechanism in inborn errors of metabolism. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18835424&form=6&db=m Neuropathic pain and temporal expression of preprodynorphin, protein kinase C and N-methyl-D-aspartate receptor subunits after spinal cord injury. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29947256&form=6&db=m Comparison of Mesenchymal Stromal Cells Isolated from Murine Adipose Tissue and Bone Marrow in the Treatment of Spinal Cord Injury. unassigned - 2.7.11.13 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34193687&form=6&db=m Dexmedetomidine Reduces the Lidocaine-Induced Neurotoxicity by Inhibiting Inflammasome Activation and Reducing Pyroptosis in Rats. ongoing research,unassigned 2,0 2.7.11.13 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2237967&form=6&db=m Protein phosphorylation during ischemia. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549583&form=6&db=m Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice. causal interaction,unassigned 1,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14676051&form=6&db=m Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma. causal interaction,unassigned 4,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313841&form=6&db=m Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15618281&form=6&db=m Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting. causal interaction,unassigned 2,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15824357&form=6&db=m The clinical and genetic spectrum of spinocerebellar ataxia 14. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16189624&form=6&db=m A novel H101Q mutation causes PKCgamma loss in spinocerebellar ataxia type 14. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409551&form=6&db=m Delayed spinocerebellar ataxia in transgenic mice expressing mutant ubiquitin. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17343273&form=6&db=m PRKCG mutation (SCA-14) causing a Ramsay Hunt phenotype. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493614&form=6&db=m Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. causal interaction,unassigned 4,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17562946&form=6&db=m Another mutation in cysteine 131 in protein kinase C gamma as a cause of spinocerebellar ataxia type 14. causal interaction,unassigned 4,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17822669&form=6&db=m Protection from ataxia-linked apoptosis by gap junction inhibitors. causal interaction,unassigned 4,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18005063&form=6&db=m Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress. causal interaction,unassigned 4,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577575&form=6&db=m PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18986758&form=6&db=m Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG. causal interaction,unassigned 1,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056342&form=6&db=m Loss of Purkinje cells in the PKCgamma H101Y transgenic mouse. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19365031&form=6&db=m Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19561170&form=6&db=m Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin. therapeutic application,unassigned 1,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398063&form=6&db=m Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy. causal interaction,unassigned 4,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21906004&form=6&db=m Molecular pathophysiology of neurodegenerative disease caused by ?PKC mutations. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949352&form=6&db=m Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila. causal interaction,diagnostic usage,unassigned 2,3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604456&form=6&db=m A novel mutation in the C2 domain of protein kinase C gamma associated with spinocerebellar ataxia type 14. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24030789&form=6&db=m Clinical and Neurophysiological Profile of Four German Families with Spinocerebellar Ataxia Type 14. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24134140&form=6&db=m SCA14 mutation V138E leads to partly unfolded PKC? associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization. unassigned - 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24744737&form=6&db=m Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24937631&form=6&db=m Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14. unassigned - 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25217572&form=6&db=m Identification and characterization of PKC?, a kinase associated with SCA14, as an amyloidogenic protein. therapeutic application,unassigned 1,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26399641&form=6&db=m Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKC? Activity and Regulates Purkinje Cell Dendritic Growth. ongoing research,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28554312&form=6&db=m Calcium signaling, PKC gamma, IP3R1 and CAR8 link spinocerebellar ataxias and Purkinje cell dendritic development. causal interaction,unassigned 4,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28738819&form=6&db=m Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14. causal interaction,unassigned 3,0 2.7.11.13 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30312605&form=6&db=m Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. causal interaction,unassigned 3,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10368655&form=6&db=m Local inflammation may influence oral tumor cell differentiation. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11914646&form=6&db=m Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429646&form=6&db=m Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1). causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789153&form=6&db=m Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15641106&form=6&db=m Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374540&form=6&db=m Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407847&form=6&db=m N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells. unassigned - 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17018591&form=6&db=m Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19117988&form=6&db=m A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19199036&form=6&db=m Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567682&form=6&db=m Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20407013&form=6&db=m Activation by Tyrosine Phosphorylation as a Prerequisite for Protein Kinase C{zeta} to Mediate Epidermal Growth Factor Receptor Signaling to ERK. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20967867&form=6&db=m Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750277&form=6&db=m Ectopic Expression of Protein Kinase C-? Sensitizes Head and Neck Squamous Cell Carcinoma to Diterpene Esters. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396949&form=6&db=m Atypical Protein Kinase C ?/? Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma. causal interaction,unassigned 4,0 2.7.11.13 Staphylococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19185618&form=6&db=m Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8317760&form=6&db=m Possible involvement of protein kinase C with induction of haptoglobin in cows by treatment with dexamethasone and by starvation. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8482377&form=6&db=m Protein kinase C isoenzymes in human neuroblasts. Involvement of PKC epsilon in cell differentiation. unassigned - 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9935181&form=6&db=m Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: implications for cell death. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676843&form=6&db=m Induction of protein kinase Czeta-related protein kinase by growth suppression in carcinogen-initiated epidermal cell-line WYF31 cells. causal interaction,unassigned 1,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115559&form=6&db=m Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11339825&form=6&db=m Selective degradation of the PKC-epsilon isoform during cell death in AKR-2B fibroblasts. ongoing research,unassigned 3,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883037&form=6&db=m Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785460&form=6&db=m A Protein Kinase C{epsilon}-Anti-apoptotic Kinase Signaling Complex Protects Human Vascular Endothelial Cells against Apoptosis through Induction of Bcl-2. therapeutic application,unassigned 1,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18401527&form=6&db=m Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18670192&form=6&db=m Regulation of ER stress-induced macroautophagy by protein kinase C. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19797084&form=6&db=m Translational Control of Protein Kinase C{eta} by Two Upstream Open Reading Frames (uORFs). causal interaction,unassigned 2,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20398630&form=6&db=m Protein kinase C inhibits autophagy and phosphorylates LC3. ongoing research,unassigned 1,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22465675&form=6&db=m siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat. therapeutic application,unassigned 1,0 2.7.11.13 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251520&form=6&db=m The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity. unassigned - 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331919&form=6&db=m Seizures selectively impair agonist-stimulated phosphoinositide hydrolysis without affecting protein kinase C activity in rat brain. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15058486&form=6&db=m Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16901909&form=6&db=m Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17167071&form=6&db=m Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus. therapeutic application,unassigned 1,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18184780&form=6&db=m Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. unassigned - 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18596877&form=6&db=m Impact of protein kinase C activation on status epilepticus and epileptogenesis: oh, what a tangled web. therapeutic application,unassigned 1,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18715754&form=6&db=m Impact of protein kinase C activation on epileptiform activity in the hippocampal slice. causal interaction,unassigned 3,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774262&form=6&db=m mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice. ongoing research,unassigned 3,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21731076&form=6&db=m Pilocarpine-induced status epilepticus alters hippocampal PKC expression in mice. ongoing research,unassigned 4,0 2.7.11.13 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24952362&form=6&db=m The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1356853&form=6&db=m Protein kinase C inhibits histamine H2 receptor-mediated stimulation of cyclic AMP content in the human gastric cancer cell line HGT-1. ongoing research,unassigned 4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2637248&form=6&db=m The effect of phorbol esters on cell growth and epidermal growth factor receptor modulation in a human gastric carcinoma cell line TMK-1. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7544678&form=6&db=m The alpha isoform of protein kinase C inhibits histamine-stimulated adenylate cyclase activity in a particulate fraction of the human gastric cancer cell line HGT-1. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8359445&form=6&db=m Protein kinase C alpha is the isoform responsible for inhibition of histamine H2 receptor mediated stimulation of adenylate cyclase in the human gastric cancer cell line HGT-1. ongoing research,unassigned 3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393830&form=6&db=m Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8408180&form=6&db=m Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8433394&form=6&db=m Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639807&form=6&db=m [Co-regulative effect of PKA-RII and PKC-alpha kinase subspecies on expression of c-myc and c-H-ras in human gastric cancer cells (MGC 80-3)] ongoing research,unassigned 3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027304&form=6&db=m Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523838&form=6&db=m Protein kinase Calpha promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10548353&form=6&db=m Pharmacological inhibition of protein kinase C activity could induce apoptosis in gastric cancer cells by differential regulation of apoptosis-related genes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278696&form=6&db=m Aberrant expression of human mucin gene MUC5B in gastric carcinoma and cancer cells. Identification and regulation of a distal promoter. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11295059&form=6&db=m Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line. therapeutic application,unassigned 1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483859&form=6&db=m Down-regulation of protein kinase C activity by sorbitol rapidly induces apoptosis in human gastric cancer cell lines. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11491013&form=6&db=m Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human hepatocellular and gastric cancer xenografts. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11783010&form=6&db=m [Expression and function of protein kinase C-alpha and beta I isoenzymes in drug-resistant gastric cancer cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11798893&form=6&db=m [Alteration of subcellular distribution of protein kinase C isoforms in swelling-activated multi-drug-resistant gastric cancer cells and its significance] diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12046066&form=6&db=m Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121875&form=6&db=m Stimulation of the gastrin-cholecystokinin(B) receptor promotes branching morphogenesis in gastric AGS cells. ongoing research,unassigned 4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470903&form=6&db=m Involvement of TNF-alpha changes in human cancer development, prevention and palliative care. ongoing research,unassigned 2,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14606067&form=6&db=m Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087026&form=6&db=m [Effect of PKC inhibitor on P-gp expression and drug-resistance in MGC803 cells] ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313921&form=6&db=m Antisense targeting protein kinase C alpha and beta1 inhibits gastric carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15744586&form=6&db=m Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054131&form=6&db=m EGF rapidly translocates tight junction proteins from the cytoplasm to the cell-cell contact via protein kinase C activation in TMK-1 gastric cancer cells. unassigned - 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16638134&form=6&db=m SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17253132&form=6&db=m Aspirin-induced apoptosis in human gastric cancer epithelial cells: relationship with protein kinase C signaling. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339873&form=6&db=m Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18759046&form=6&db=m PKCalpha translocation from mitochondria to nucleus is closely related to induction of apoptosis in gastric cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19291828&form=6&db=m Antisense expression of PKCalpha improved sensitivity of SGC7901/VCR cells to doxorubicin. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19774416&form=6&db=m High Expression of Atypical Protein Kinase C lambda/iota in Gastric Cancer as a Prognostic Factor for Recurrence. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428959&form=6&db=m 12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442164&form=6&db=m Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25724188&form=6&db=m Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30849478&form=6&db=m Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin ?-1/NF-?B signaling pathway. unassigned - 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31570472&form=6&db=m Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer. causal interaction,unassigned 3,0 2.7.11.13 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660148&form=6&db=m Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 2.7.11.13 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10550332&form=6&db=m Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1520407&form=6&db=m Protein kinase C activity in permanent focal cerebral ischemia. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12131532&form=6&db=m Cerebrovascular alterations in pressure and protein kinase C-mediated constriction in Dahl salt-sensitive rats. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15885569&form=6&db=m Protein kinase C isozymes in stroke. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16450214&form=6&db=m Protein Kinase C Family Members as a Target for Regulation of Blood-Brain Barrier Na,K,2Cl-Cotransporter During In Vitro Stroke Conditions and Nicotine Exposure. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785226&form=6&db=m Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204679&form=6&db=m Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293847&form=6&db=m Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17563398&form=6&db=m Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19063870&form=6&db=m Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats. therapeutic application,unassigned 3,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19233655&form=6&db=m Neuroprotective versus tumorigenic protein kinase C activators. therapeutic application,unassigned 1,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321442&form=6&db=m Pick1-mediated glutamate receptor subunit 2 (GLUR2) trafficking contributes to cell death in oxygen/glucose deprived hippocampal neurons. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22275068&form=6&db=m The binding affinities of proteins interacting with the PDZ domain of PICK1. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24534126&form=6&db=m Impact of the 1425G/A Polymorphism of PRKCH on the Recurrence of Ischemic Stroke: Fukuoka Stroke Registry. causal interaction,unassigned 3,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970394&form=6&db=m Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385957&form=6&db=m The role of protein kinase C in ischemic tolerance induced by hyperoxia in rats with stroke. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28482641&form=6&db=m Bryostatin Effects on Cognitive Function and PKC? in Alzheimer's Disease Phase IIa and Expanded Access Trials. unassigned - 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28827087&form=6&db=m Cerebrovascular recovery after stroke with individual and combined losartan and captopril treatment of SHRsp. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30872361&form=6&db=m Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke. therapeutic application,unassigned 1,0 2.7.11.13 Stroke, Lacunar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17206144&form=6&db=m A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Stroke, Lacunar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164711&form=6&db=m Association between PRKCH gene polymorphisms and subcortical silent brain infarction. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Stuttering http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174462&form=6&db=m AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. therapeutic application,unassigned 1,0 2.7.11.13 Subacute Sclerosing Panencephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14556073&form=6&db=m Comparison of the effects of phorbol dibutyrate and low-frequency stimulation of synaptic inputs on the excitability of myenteric AH neurons. ongoing research,unassigned 2,0 2.7.11.13 Subacute Sclerosing Panencephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15507400&form=6&db=m Evidence for protein kinase involvement in long-term postsynaptic excitation of intrinsic primary afferent neurons in the intestine. causal interaction,unassigned 4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1407457&form=6&db=m Relation between protein kinase C and calmodulin systems in cerebrovascular contraction: investigation of the pathogenesis of vasospasm after subarachnoid hemorrhage. unassigned - 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1545258&form=6&db=m Direct evidence for a key role of protein kinase C in the development of vasospasm after subarachnoid hemorrhage. causal interaction,unassigned 3,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1983998&form=6&db=m Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm. ongoing research,unassigned 4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7570748&form=6&db=m Chronological changes of arterial diameter, cGMP, and protein kinase C in the development of vasospasm. ongoing research,unassigned 2,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7700574&form=6&db=m The immunohistochemical distribution of protein kinase C isozymes is altered in the canine brain and basilar artery after subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8436616&form=6&db=m Role of protein kinase C in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8478399&form=6&db=m Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage. ongoing research,unassigned 2,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8714544&form=6&db=m Interrelation between protein kinase C and nitric oxide in the development of vasospasm after subarachnoid hemorrhage. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8841349&form=6&db=m Protein kinase C has two different major roles in lattice compaction enhanced by cerebrospinal fluid from patients with subarachnoid hemorrhage. diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9329037&form=6&db=m Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9347985&form=6&db=m Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery. diagnostic usage,therapeutic application,unassigned 3,4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575313&form=6&db=m Various pathogenetic factors revolving around the central role of protein kinase C activation in the occurrence of cerebral vasospasm causal interaction,unassigned 4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10856455&form=6&db=m Protein kinase cdelta and alpha are involved in the development of vasospasm after subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874686&form=6&db=m Role of protein kinase C in cerebral vasospasm: past and future. causal interaction,unassigned 3,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11862760&form=6&db=m [Role of protein kinase C isozymes in cellular functions and pathological conditions] ongoing research,unassigned 2,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11877907&form=6&db=m High-dose methylprednisolone prevents vasospasm after subarachnoid hemorrhage through inhibition of protein kinase C activation. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12445353&form=6&db=m Chronological changes of the contractile mechanism in prolonged vasospasm after subarachnoid hemorrhage: from protein kinase C to protein tyrosine kinase. ongoing research,unassigned 2,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637369&form=6&db=m Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm. causal interaction,unassigned 4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657973&form=6&db=m Cerebral vasospasm after subarachnoid hemorrhage. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12739235&form=6&db=m Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12808353&form=6&db=m Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. therapeutic application,unassigned 4,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637442&form=6&db=m Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model. unassigned - 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786270&form=6&db=m In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCalpha and zeta. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032736&form=6&db=m Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23351051&form=6&db=m Inhibition of protein kinase C signal reduces ET receptor expression and basilar vasospasm after subarachnoid hemorrhage in rats. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520180&form=6&db=m Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. causal interaction,unassigned 4,0 2.7.11.13 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16683253&form=6&db=m Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. therapeutic application,unassigned 1,0 2.7.11.13 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19194472&form=6&db=m Protein Kinase Cvarepsilon Inhibits UVR-Induced Expression of FADD, an Adaptor Protein, Linked to both Fas- and TNFR1-Mediated Apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Synucleinopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Systemic Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10540175&form=6&db=m The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498543&form=6&db=m Tachycardia preconditions infarct size in dogs: role of adenosine and protein kinase C. ongoing research,unassigned 4,0 2.7.11.13 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21486607&form=6&db=m Frontiers in immunosuppression. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Takayasu Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7650841&form=6&db=m Role of calcium and protein kinase C in the activation of T cells in Takayasu's arteritis. ongoing research,unassigned 2,0 2.7.11.13 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16691114&form=6&db=m Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Temporomandibular Joint Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17306466&form=6&db=m Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4 2.7.11.13 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660486&form=6&db=m Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity. ongoing research,unassigned 4,0 2.7.11.13 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7961696&form=6&db=m Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8218362&form=6&db=m Retinoic acid stimulates the protein kinase C pathway before activation of its beta-nuclear receptor during human teratocarcinoma differentiation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8243888&form=6&db=m Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation. ongoing research,unassigned 3,0 2.7.11.13 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940046&form=6&db=m Differentiation of F9 teratocarcinoma stem cells to primitive endoderm is regulated by the Gialpha2/Gsalpha axis via phospholipase C and not adenylylcyclase. unassigned - 2.7.11.13 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375394&form=6&db=m The subcellular distribution of protein kinase Calpha, -epsilon, and -zeta isoforms during cardiac cell differentiation. ongoing research,unassigned 3,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258705&form=6&db=m PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20562896&form=6&db=m A newly discovered mutation in PICK1 in a human with globozoospermia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21397063&form=6&db=m DPY19L2 Deletion as a Major Cause of Globozoospermia. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22049801&form=6&db=m [Molecular genetics of globozoospermia: an update]. unassigned - 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22571172&form=6&db=m Molecular cytogenetic and genetic aspects of globozoospermia: a review. causal interaction,unassigned 3,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100262&form=6&db=m Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265589&form=6&db=m A Homozygous Deletion of the DPY19l2 Gene is a Cause of Globozoospermia in Men from the Republic of Macedonia. causal interaction,unassigned 3,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25711835&form=6&db=m Genetic aspects of monomorphic teratozoospermia: a review. causal interaction,unassigned 3,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26306493&form=6&db=m ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. causal interaction,unassigned 3,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970394&form=6&db=m Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27086357&form=6&db=m A new mutation identified in SPATA16 in two globozoospermic patients. unassigned - 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27441053&form=6&db=m Assessment of DPY19L2 Deletion in Familial and Non-Familial Individuals with Globozoospermia and DPY19L2 Genotyping. unassigned - 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30584989&form=6&db=m Embryos derived from couples with consanguineous marriages with globozoospermia should be screened for gender or DPY19L2 deletion. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212452&form=6&db=m [Advances in the studies of teratospermia-related genes]. therapeutic application,unassigned 2,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32582379&form=6&db=m Identification of a novel deletion mutation in DPY19L2 from an infertile patient with globozoospermia: a case report. therapeutic application,unassigned 1,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33108537&form=6&db=m Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player. diagnostic usage,unassigned 2,0 2.7.11.13 Teratozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34209343&form=6&db=m Molecular Analysis of DPY19L2, PICK1 and SPATA16 in Italian Unrelated Globozoospermic Men. diagnostic usage,unassigned 3,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1557361&form=6&db=m Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1814011&form=6&db=m Tetanus toxin inhibits neurotensin-induced mobilization of cytosolic protein kinase C activity in NG-108 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1967213&form=6&db=m Inhibition of functional properties of tetanus antigen-specific T-cell clones by envelope glycoprotein GP120 of human immunodeficiency virus. unassigned - 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158677&form=6&db=m Tetanus toxin attenuates the ability of phorbol myristate acetate to mobilize cytosolic protein kinase C in NG-108 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2290129&form=6&db=m The study of clostridial and related toxins. The search for unique mechanisms and common denominators. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2293621&form=6&db=m In vivo translocation and down-regulation of protein kinase C following intraventricular administration of tetanus toxin. therapeutic application,unassigned 2,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2332053&form=6&db=m Tetanus toxin-induced protein kinase C activation and elevated serotonin levels in the perinatal rat brain. causal interaction,diagnostic usage,unassigned 1,2,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2672464&form=6&db=m Protein kinase C and long-term potentiation in the hippocampus. causal interaction,unassigned 1,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3283262&form=6&db=m Diminished activity of protein kinase C in tetanus toxin-treated macrophages and in the spinal cord of mice manifesting generalized tetanus intoxication. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3392539&form=6&db=m Effects of tetanus toxin on catecholamine release from intact and digitonin-permeabilized chromaffin cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8167789&form=6&db=m Cellular responses to acute injury: the role of the plasma membrane in cell response to two clostridial toxins. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8194081&form=6&db=m Protein kinase C and clostridial neurotoxins affect discrete and related steps in the secretory pathway. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8348292&form=6&db=m Metabotropic receptor stimulation coupled to weak tetanus leads to long-term potentiation and a rapid elevation of cytosolic protein kinase C activity. unassigned - 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8419545&form=6&db=m GT1b ganglioside prevents tetanus toxin-induced protein kinase C activation and down-regulation in the neonatal brain in vivo. unassigned - 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9523581&form=6&db=m Tetanus toxin enhances protein kinase C activity translocation and increases polyphosphoinositide hydrolysis in rat cerebral cortex preparations. therapeutic application,unassigned 1,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10996319&form=6&db=m Activation of signal transduction pathways involving trkA, PLCgamma-1, PKC isoforms and ERK-1/2 by tetanus toxin. causal interaction,unassigned 3,0 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336640&form=6&db=m HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction. unassigned - 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12590935&form=6&db=m Serotonin transport is modulated differently by tetanus toxin and growth factors. unassigned - 2.7.11.13 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699674&form=6&db=m Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity. therapeutic application,unassigned 1,0 2.7.11.13 Thecoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17895316&form=6&db=m The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Thrombasthenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11137079&form=6&db=m Platelet HDL(3) binding sites are not related to integrin alpha(IIb)beta(3) (GPIIb-IIIa). ongoing research,unassigned 2,0 2.7.11.13 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14525764&form=6&db=m Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation. ongoing research,unassigned 1,0 2.7.11.13 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16624065&form=6&db=m [Analysis of protein kinase C activity of peripheral blood T lymphocytes in children with acute idiopathic thrombocytopenic purpura] diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.13 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25359855&form=6&db=m Protein kinase C ? deficiency enhances megakaryopoiesis and recovery from thrombocytopenia. causal interaction,unassigned 2,0 2.7.11.13 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257684&form=6&db=m Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C ?. unassigned - 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8946264&form=6&db=m Basic research in antioxidant inhibition of steps in atherogenesis. therapeutic application,unassigned 2,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210570&form=6&db=m Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets. causal interaction,unassigned 3,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815612&form=6&db=m Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147982&form=6&db=m PKCalpha regulates platelet granule secretion and thrombus formation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19969380&form=6&db=m Protein kinase Calpha: disease regulator and therapeutic target. unassigned - 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20002545&form=6&db=m Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20479008&form=6&db=m Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. ongoing research,unassigned 1,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21527521&form=6&db=m Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21596041&form=6&db=m Unravelling the different functions of protein kinase C isoforms in platelets. causal interaction,unassigned 4,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21944869&form=6&db=m Protein kinase C-theta in platelet activation. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21951302&form=6&db=m Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis. therapeutic application,unassigned 1,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22812584&form=6&db=m Protein kinase C? and protein kinase C? double-deficient mice have a bleeding diathesis. unassigned - 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22881838&form=6&db=m The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner. causal interaction,unassigned 1,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542698&form=6&db=m Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. therapeutic application,unassigned 1,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24433221&form=6&db=m CGX1037 is a novel PKC isoform delta selective inhibitor in platelets. diagnostic usage,unassigned 2,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28739484&form=6&db=m Protein kinase C?/? is dispensable for platelet function in thrombosis and hemostasis in mice. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28758099&form=6&db=m Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30409037&form=6&db=m Type-2 diabetes mellitus and cardiovascular disease. causal interaction,unassigned 4,0 2.7.11.13 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31770438&form=6&db=m Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis. unassigned - 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1560050&form=6&db=m Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2005106&form=6&db=m Protein kinase C isozyme expression in phorbol ester-sensitive and -resistant EL4 thymoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2212653&form=6&db=m Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E. ongoing research,unassigned 4,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2524528&form=6&db=m Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction. unassigned - 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2784444&form=6&db=m Comparison of phorbol-12-myristate-13-acetate and dioctanoyl-sn-glycerol in the activation of EL4/6.1 thymoma cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036347&form=6&db=m Absence of protein kinase C in nuclei of EL4 mouse thymoma cells. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3265048&form=6&db=m Proteolytic degradation of protein kinase C in the phorbol ester-induced interleukin-2 secreting thymoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3359648&form=6&db=m Concanavalin A- or phorbol ester-induced translocation of protein kinase C in thymoma cells from a patient with myasthenia gravis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3490845&form=6&db=m Lack of direct effect of 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) on protein kinase C activity in EL4 cells. ongoing research,unassigned 4,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3698022&form=6&db=m Substrates for protein kinase C in cytosol of EL4 mouse thymoma cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7925438&form=6&db=m Expression and biochemical characterization of human protein kinase C-theta. causal interaction,unassigned 1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8657160&form=6&db=m Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. unassigned - 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8674762&form=6&db=m Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells. ongoing research,unassigned 2,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187123&form=6&db=m Selective up-regulation of protein kinase C eta in phorbol ester-sensitive versus -resistant EL4 mouse thymoma cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9328180&form=6&db=m Effects of protein kinase C activators on phorbol ester-sensitive and -resistant EL4 thymoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549843&form=6&db=m Interleukin-1 beta induced synthesis of protein kinase C-delta and protein kinase C-epsilon in EL4 thymoma cells: possible involvement of phosphatidylinositol 3-kinase. causal interaction,unassigned 1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19424853&form=6&db=m Calorie restriction initiated at a young age activates the Akt/PKCzeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner. causal interaction,unassigned 1,0 2.7.11.13 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29853830&form=6&db=m Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation. unassigned - 2.7.11.13 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1451074&form=6&db=m Protein kinase C activity in human thyroid carcinoma and adenoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760657&form=6&db=m [Growth and invasion of differentiated thyroid gland carcinoma: importance of signal transduction] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.13 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534528&form=6&db=m Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKCepsilon in PCCL3 thyroid cells. unassigned - 2.7.11.13 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31568662&form=6&db=m Growth-associated protein 43 promotes thyroid cancer cell lines progression via epithelial-mesenchymal transition. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33716239&form=6&db=m Silencing circRNA protein kinase C iota (circ-PRKCI) suppresses cell progression and glycolysis of human papillary thyroid cancer through circ-PRKCI/miR-335/E2F3 ceRNA axis. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1451074&form=6&db=m Protein kinase C activity in human thyroid carcinoma and adenoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1696850&form=6&db=m Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7491516&form=6&db=m Increased plasminogen activator and type IV collagenase activity in invasive follicular thyroid carcinoma cells. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7651730&form=6&db=m The natural protein kinase C alpha mutant is present in human thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8620458&form=6&db=m Tamoxifen antagonizes proliferation and invasion of estrogen receptor-negative metastatic follicular thyroid cancer cells via protein kinase C. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038375&form=6&db=m Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9275066&form=6&db=m Suppression of thyrotropin receptor-G protein-phospholipase C coupling by activation of protein kinase C in thyroid carcinoma cells. ongoing research,unassigned 2,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492149&form=6&db=m Intercellular adhesion molecule-1 is upregulated via the protein kinase C pathway in human thyroid carcinoma cell lines. ongoing research,unassigned 4,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10438519&form=6&db=m Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. ongoing research,unassigned 3,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384739&form=6&db=m Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis. ongoing research,unassigned 3,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994357&form=6&db=m Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173071&form=6&db=m Effects of the putatively oncogenic protein kinase Calpha D294G mutation on enzymatic activity and cell growth and its occurrence in human thyroid neoplasias. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16646678&form=6&db=m Activation of Protein Kinase C delta Induces Growth Arrest in NPA Thyroid Cancer Cells Through Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18372514&form=6&db=m Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116345&form=6&db=m Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501673&form=6&db=m S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration. therapeutic application,unassigned 4,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22374978&form=6&db=m Protein Kinase C: A Putative New Target for the Control of Human Medullary Thyroid Carcinoma Cell Proliferation in Vitro. ongoing research,unassigned 4,0 2.7.11.13 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26633361&form=6&db=m The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions. unassigned - 2.7.11.13 Thyroiditis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459638&form=6&db=m Elevation of protein kinase C in thyrocytes isolated from a Lewis rat model of autoimmune thyroiditis prevents assembly of immunodetectable connexin43 gap junctions and reduces intercellular communication. ongoing research,unassigned 2,0 2.7.11.13 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775562&form=6&db=m Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway. therapeutic application,unassigned 1,0 2.7.11.13 Tooth Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17502419&form=6&db=m Myelin protein zero/P0 phosphorylation and function require an adaptor protein linking it to RACK1 and PKC alpha. causal interaction,unassigned 3,0 2.7.11.13 Transfusion-Related Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22853798&form=6&db=m Activation of platelet protein kinase C by ultraviolet light B mediates platelet transfusion-related acute lung injury in a two-event animal model. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Trauma, Nervous System http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16179609&form=6&db=m Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons. causal interaction,unassigned 3,0 2.7.11.13 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23364795&form=6&db=m MicroRNA-31 Sensitizes Human Breast Cells to Apoptosis by Direct Targeting of Protein Kinase C {epsilon} (PKC{epsilon}). causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27357025&form=6&db=m Protein kinase C ? is involved in the regulation of AXL receptor tyrosine kinase expression in triple-negative breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 2.7.11.13 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27542222&form=6&db=m MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase C?-based triple-negative breast cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28515445&form=6&db=m Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289335&form=6&db=m Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32600444&form=6&db=m PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7559098&form=6&db=m Activation of protein kinase C by mycobacterial cord factor, trehalose 6-monomycolate, resulting in tumor necrosis factor-alpha release in mouse lung tissues. unassigned - 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470903&form=6&db=m Involvement of TNF-alpha changes in human cancer development, prevention and palliative care. ongoing research,unassigned 2,0 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785544&form=6&db=m Impaired generation of reactive oxygen species during differentiation of dendritic cells (DCs) by Mycobacterium tuberculosis secretory antigen (MTSA) and subsequent activation of MTSA-DCs by mycobacteria results in increased intracellular survival. therapeutic application,unassigned 1,0 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18503635&form=6&db=m Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages. unassigned - 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20030858&form=6&db=m Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG. causal interaction,unassigned 3,0 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25544312&form=6&db=m Arabinosylated lipoarabinomannan (Ara-LAM) mediated intracellular mechanisms against tuberculosis infection: Involvement of protein kinase C (PKC) mediated signaling. unassigned - 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28203237&form=6&db=m Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt-Wnt Situation. unassigned - 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28832027&form=6&db=m Protein kinase C-delta (PKC?), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice. unassigned - 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29346346&form=6&db=m Protein kinase C-delta (PKC?), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice. unassigned - 2.7.11.13 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31455656&form=6&db=m CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.13 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28286738&form=6&db=m TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts. therapeutic application,unassigned 3,0 2.7.11.13 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8493290&form=6&db=m Translocation of protein kinase C in human platelets by patients with chronic uremia. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30439378&form=6&db=m Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.13 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17085202&form=6&db=m Partial bladder outlet obstruction selectively abolishes protein kinase C induced contraction of rabbit detrusor smooth muscle. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21883831&form=6&db=m Role of Rho-kinase and protein kinase C during contraction of hypertrophic detrusor in mice with partial urinary bladder outlet obstruction. ongoing research,unassigned 3,0 2.7.11.13 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22396250&form=6&db=m Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of ?-toxin permeabilized guinea pig detrusor smooth muscle. ongoing research,unassigned 2,0 2.7.11.13 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23269650&form=6&db=m Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels. unassigned - 2.7.11.13 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8620437&form=6&db=m Specific sequences of fibronectin activate the protein kinase C signal transduction pathway in invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.7.11.13 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10937066&form=6&db=m Protein kinase C (PKC) isoenzymes immunohistochemistry in lymph node revealing solution-fixed, paraffin-embedded bladder tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11554166&form=6&db=m Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19322013&form=6&db=m Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19429443&form=6&db=m Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus. causal interaction,unassigned 1,0 2.7.11.13 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25752336&form=6&db=m Reduction of protein kinase C ? (PKC-?) promote apoptosis via down-regulation of Dicer in bladder cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32141538&form=6&db=m PKC? and Netrin-1/UNC5B positive feedback control in relation with chemical therapy in bladder cancer. therapeutic application,unassigned 4,0 2.7.11.13 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32222457&form=6&db=m Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2. ongoing research,unassigned 1,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9763633&form=6&db=m Involvement of PKC-alpha in regulatory volume decrease responses and activation of volume-sensitive chloride channels in human cervical cancer HT-3 cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9774953&form=6&db=m Multimodality therapy: radiation and continuous concomitant cis-platinum and PKC inhibition in a cervical carcinoma model. ongoing research,therapeutic application,unassigned 3,4,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11642552&form=6&db=m Protein kinase C modulates telomerase activity in human cervical cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17257588&form=6&db=m PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. causal interaction,unassigned 1,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18156791&form=6&db=m Discovery of cyclin-dependent kinase inhibitor, CR229, using structurebased drug screening. ongoing research,unassigned 2,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363674&form=6&db=m Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895402&form=6&db=m Over-expression of protein kinase C?isoforms (?, ?, ? and ?) in squamous cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28246354&form=6&db=m Protein kinase C ? inhibits autophagy and sensitizes cervical cancer Hela cells to cisplatin. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048616&form=6&db=m The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.7.11.13 Uterine Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1559622&form=6&db=m Enhancement of growth-promoting activity in extract from uterine cancers by protein kinase C in human endometrial fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392164&form=6&db=m Protein kinase Czeta (PKCzeta) regulates ocular inflammation and apoptosis in endotoxin-induced uveitis (EIU): signaling molecules involved in EIU resolution by PKCzeta inhibitor and interleukin-13. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.13 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1977871&form=6&db=m Production of a non-functional nef protein in human immunodeficiency virus type 1-infected CEM cells. unassigned - 2.7.11.13 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523838&form=6&db=m Protein kinase Calpha promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21346188&form=6&db=m Protein kinase C {delta} regulates vaccinia related kinase 1 in DNA damage induced apoptosis. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25445591&form=6&db=m Protein kinase C regulates vascular calcification via cytoskeleton reorganization and osteogenic signaling. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11104300&form=6&db=m Protein kinase C activation and its pharmacological inhibition in vascular disease. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18291120&form=6&db=m Differential roles of PKCalpha and PKCvarepsilon in controlling the gene expression of Nox4 in human endothelial cells. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168729&form=6&db=m Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction. unassigned - 2.7.11.13 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19955485&form=6&db=m AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease. unassigned - 2.7.11.13 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22719800&form=6&db=m The impact of thiamine treatment in the diabetes mellitus. causal interaction,unassigned 3,0 2.7.11.13 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23580870&form=6&db=m Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24440741&form=6&db=m Protein kinase C isoforms in atherosclerosis: pro- or anti-inflammatory? causal interaction,unassigned 4,0 2.7.11.13 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1682439&form=6&db=m Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. therapeutic application,unassigned 2,0 2.7.11.13 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7513644&form=6&db=m Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase. therapeutic application,unassigned 1,0 2.7.11.13 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8606529&form=6&db=m Activation of protein kinase C as a modulator of potentiated UK-14304-induced contractions in dog mesenteric artery and vein. ongoing research,unassigned 2,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3292684&form=6&db=m Generation of neutrophil chemotactic activity by phorbol ester-stimulated calf pulmonary artery endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9676640&form=6&db=m The Ca2+-dependent isozymes of protein kinase C are uniquely important in the enhanced growth of immature adventitial fibroblasts isolated from the bovine pulmonary arterial wall at a time of heightened susceptibility to vascular injury. causal interaction,unassigned 2,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12017760&form=6&db=m [Epidemiology, pathogenesis and therapy of diabetic retinopathy and maculopathy] causal interaction,unassigned 1,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15662033&form=6&db=m Central role of PKCbeta in neointimal expansion triggered by acute arterial injury. ongoing research,unassigned 2,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16640963&form=6&db=m Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16679391&form=6&db=m Essential role of PKC-{zeta} in normal and angiotensin II-accelerated neointimal growth after vascular injury. unassigned - 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19433059&form=6&db=m PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20594553&form=6&db=m Reduction of PKCbetaII activity in smooth muscle cells attenuates acute arterial injury. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30739581&form=6&db=m Novel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial Injury. causal interaction,unassigned 4,0 2.7.11.13 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32711605&form=6&db=m Effect of Activated Protein Kinase C Beta Type Mediated Phosphorylation of Signal Transducer and Activator of Transcription 4 on Proliferation and Phenotypic Transformation of Vascular Smooth Muscle Cells After Vascular Injury Induced by Nano-SiO?. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370069&form=6&db=m Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1983998&form=6&db=m Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm. ongoing research,unassigned 4,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7714610&form=6&db=m Protein kinase C and diacylglycerol content in basilar arteries during experimental cerebral vasospasm in the dog. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7931591&form=6&db=m The effects of papaverine on phorbol dibutyrate-induced vasoconstriction in brain slice microvessels. causal interaction,unassigned 4,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8436616&form=6&db=m Role of protein kinase C in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8478399&form=6&db=m Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage. ongoing research,unassigned 2,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8571439&form=6&db=m Protein kinase C activation during cerebral vasospasm. causal interaction,unassigned 2,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8789664&form=6&db=m Possible mechanism to induce protein kinase C-dependent arterial smooth muscle contraction after subarachnoid haemorrhage. ongoing research,unassigned 1,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8841349&form=6&db=m Protein kinase C has two different major roles in lattice compaction enhanced by cerebrospinal fluid from patients with subarachnoid hemorrhage. diagnostic usage,therapeutic application,unassigned 1,3,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9335226&form=6&db=m Thromboxane A2 synthetase inhibitor failed to ameliorate the arterial narrowing during the chronic phase of cerebral vasospasm. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575313&form=6&db=m Various pathogenetic factors revolving around the central role of protein kinase C activation in the occurrence of cerebral vasospasm causal interaction,unassigned 4,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874686&form=6&db=m Role of protein kinase C in cerebral vasospasm: past and future. causal interaction,unassigned 3,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11487724&form=6&db=m Protein kinase C and cerebral vasospasm. unassigned - 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12142343&form=6&db=m Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. causal interaction,unassigned 3,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12454420&form=6&db=m Interactive role of tyrosine kinase, protein kinase C, and Rho/Rho kinase systems in the mechanotransduction of vascular smooth muscles. unassigned - 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637369&form=6&db=m Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm. causal interaction,unassigned 4,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12808353&form=6&db=m Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. therapeutic application,unassigned 4,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637442&form=6&db=m Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model. unassigned - 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16281914&form=6&db=m Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta, -eta and -zeta) in a rat model of cerebral basilar artery vasospasm. unassigned - 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786270&form=6&db=m In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCalpha and zeta. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23351051&form=6&db=m Inhibition of protein kinase C signal reduces ET receptor expression and basilar vasospasm after subarachnoid hemorrhage in rats. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Ventricular Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605019&form=6&db=m Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. causal interaction,unassigned 3,0 2.7.11.13 Ventricular Dysfunction, Left http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14740078&form=6&db=m Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Ventricular Dysfunction, Left http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15894568&form=6&db=m PKC-{varepsilon}-dependent survival signals in diabetic hearts. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Ventricular Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8158662&form=6&db=m Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide. ongoing research,unassigned 3,0 2.7.11.13 Ventricular Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11215534&form=6&db=m Ischemia-induced ventricular fibrillation in isolated perfused rat heart: role of alpha1A-adrenoceptor mediated activation of protein kinase C. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Ventricular Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23719203&form=6&db=m Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.13 Ventricular Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23889002&form=6&db=m Melatonin attenuates hypertension-related proarrhythmic myocardial maladaptation of connexin-43 and propensity of the heart to lethal arrhythmias. causal interaction,unassigned 1,0 2.7.11.13 Ventricular Premature Complexes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297108&form=6&db=m The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways. ongoing research,unassigned 2,0 2.7.11.13 Vertigo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32645222&form=6&db=m MicroRNA-219a-5p-mediated inhibition of CaMKII? facilitates vestibular compensation in acute vertigo by promoting protein kinase C expression. unassigned - 2.7.11.13 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659999&form=6&db=m Effects of protein kinase C inhibitors on viral entry and infectivity. ongoing research,unassigned 2,0 2.7.11.13 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2826250&form=6&db=m Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I).poly(C) in human amnion cells (UAC). unassigned - 2.7.11.13 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108877&form=6&db=m Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. unassigned - 2.7.11.13 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871960&form=6&db=m Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1942251&form=6&db=m Early signal transduction in measles virus-infected lymphocytes is unaltered, but second messengers activate virus replication. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502430&form=6&db=m Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells. ongoing research,unassigned 4,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2558652&form=6&db=m Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088852&form=6&db=m Acquired immunodeficiency in murine lymphoproliferative disease: considerations on pathogenesis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11038382&form=6&db=m Entry of influenza viruses into cells is inhibited by a highly specific protein kinase C inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160332&form=6&db=m Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. causal interaction,unassigned 4,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11701615&form=6&db=m Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes. therapeutic application,unassigned 1,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20562337&form=6&db=m H2O2 alters rat cardiac sarcomere function and protein phosphorylation through redox signaling. unassigned - 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20585398&form=6&db=m Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner. unassigned - 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21124804&form=6&db=m Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21253874&form=6&db=m Host cellular signaling induced by influenza virus. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21952047&form=6&db=m PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and ?-catenin. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25155198&form=6&db=m PKC? is required for porcine reproductive and respiratory syndrome virus replication. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26199173&form=6&db=m Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-?B-dependent mechanism. unassigned - 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29445214&form=6&db=m RACK1 is indispensable for porcine reproductive and respiratory syndrome virus replication and NF-?B activation in Marc-145 cells. causal interaction,unassigned 3,0 2.7.11.13 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32522661&form=6&db=m GSK-3-associated signaling is crucial to virus infection of cells. causal interaction,unassigned 3,0 2.7.11.13 Visna http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157878&form=6&db=m Inhibition of lymphoproliferation and protein kinase C by synthetic peptides with sequence identity to the transmembrane and Q proteins of visna virus. unassigned - 2.7.11.13 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7738187&form=6&db=m 1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes. unassigned - 2.7.11.13 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116739&form=6&db=m Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Vitreoretinopathy, Proliferative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15821349&form=6&db=m The inhibition of CA2+ influx induced by hypericin in cultured human retinal pigment epithelial cells analyzed by confocal imaging. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Vitreoretinopathy, Proliferative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374044&form=6&db=m Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatonin. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Vitreoretinopathy, Proliferative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23626468&form=6&db=m The inhibitory effect of small interference RNA protein kinase C-alpha on the experimental proliferative vitreoretinopathy induced by dispase in mice. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 von Willebrand Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29925524&form=6&db=m Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets. unassigned - 2.7.11.13 Waldenstrom Macroglobulinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284528&form=6&db=m Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia. therapeutic application,unassigned 2,0 2.7.11.13 Waldenstrom Macroglobulinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17877845&form=6&db=m Novel agents in the treatment of Waldenström's macroglobulinemia. therapeutic application,unassigned 3,0 2.7.11.13 Warts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845901&form=6&db=m PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1284924&form=6&db=m Pertussis toxin stimulates the secretion of [Met5]-enkephalin and the expression of proenkephalin A mRNA in bovine adrenal medullary chromaffin cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,4 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311408&form=6&db=m Platelet-activating factor stimulates phosphoinositide turnover in neurohybrid NCB-20 cells: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins and inhibition by protein kinase C. causal interaction,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312437&form=6&db=m Endothelin-1 suppression of rat adipocyte precursor cell differentiation in serum-free culture. causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1317654&form=6&db=m Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1322709&form=6&db=m Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324505&form=6&db=m Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1325668&form=6&db=m Staphylococcus albus-induced protein kinase C translocation in human neutrophils: the effect of opsonization, cytochalasin B, pertussis toxin, intra- and extracellular calcium, and R59022. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328300&form=6&db=m Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328619&form=6&db=m Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330644&form=6&db=m Polyphosphoinositide hydrolysis and protein kinase C activation in guinea pig tracheal smooth muscle cells in culture by leukotriene D4 involve a pertussis toxin sensitive G-protein. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330658&form=6&db=m Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331088&form=6&db=m A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331412&form=6&db=m Potentiation of cyclic adenosine monophosphate production by thrombin in the human erythroleukemia cell line, HEL. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335688&form=6&db=m PGE2 regulates cAMP production in cultured rabbit CCD cells: evidence for dual inhibitory mechanisms. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379246&form=6&db=m Direct activation of second messenger pathways mimics cell adhesion molecule-dependent neurite outgrowth. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1445250&form=6&db=m Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins. Potential role in integrating multiple mitogenic signalling pathways. ongoing research,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1451600&form=6&db=m Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1504143&form=6&db=m Activation of neutrophils by interleukins-1 and -2 and tumor necrosis factors. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1599449&form=6&db=m Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652560&form=6&db=m Depolarization of polymorphonuclear leukocytes by Porphyromonas (Bacteroides) gingivalis 381 in the absence of respiratory burst activation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1654071&form=6&db=m Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659225&form=6&db=m Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1663971&form=6&db=m Increased proliferation of adventitial fibroblasts from spontaneously hypertensive rat aorta. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1671790&form=6&db=m The opposing effects of calmodulin, adenosine 5'-triphosphate, and pertussis toxin on phorbol ester induced inhibition of atrial natriuretic factor stimulated guanylate cyclase in SK-NEP-1 cells. ongoing research,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1709925&form=6&db=m Activation of mitogen-activated protein kinase in BC3H1 myocytes by fluoroaluminate. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718001&form=6&db=m Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1833229&form=6&db=m Interleukin-6 stimulates motility of vascular endothelium. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845968&form=6&db=m 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. diagnostic usage,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845988&form=6&db=m Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846764&form=6&db=m Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents. diagnostic usage,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847195&form=6&db=m A functional assay to measure postsynaptic gamma-aminobutyric acidB responses in cultured spinal cord neurons: heterologous regulation of the same K+ channel. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848432&form=6&db=m Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850120&form=6&db=m Identification of endothelin receptors in cultured cerebellar neurons. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1860061&form=6&db=m Tricyclic antidepressants inhibit Ca(2+)-activated K(+)-efflux in cultured spinal cord neurons. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1909741&form=6&db=m [Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive GTP-binding protein and of protein kinase C] unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1953275&form=6&db=m [Activation mechanisms by thrombin and vasopressin of fibroblasts in spontaneously hypertensive rats] unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1965652&form=6&db=m Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2108162&form=6&db=m Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119237&form=6&db=m Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2(+)-dependent mechanism. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119477&form=6&db=m Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2129194&form=6&db=m Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2152941&form=6&db=m Pertussis toxin inhibits the FMLP-induced membrane association of protein kinase C in human neutrophils. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2153673&form=6&db=m A novel mechanism of action of corticotropin releasing factor in rat Leydig cells. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154202&form=6&db=m Tumor necrosis factor-alpha/cachectin activates the O2(-)-generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic acid. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156892&form=6&db=m Epidermal growth factor-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting tubule cells. Regulation by G protein, calcium, and protein kinase C. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2163626&form=6&db=m Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2164042&form=6&db=m The tumor necrosis factor receptor and human neutrophil function. Deactivation and cross-deactivation of tumor necrosis factor-induced neutrophil responses by receptor down-regulation. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166534&form=6&db=m Short-term regulation of Na+,K(+)-ATPase activity by dopamine. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2169285&form=6&db=m Extracellular ATP stimulates polyphosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Involvement of a pertussis toxin-sensitive guanine nucleotide binding protein and feedback inhibition by protein kinase C. ongoing research,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2174658&form=6&db=m Bombesin stimulation of mitogenesis. Specific receptors, signal transduction, and early events. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2196173&form=6&db=m Colony-stimulating factor 1 activates protein kinase C in human monocytes. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2302562&form=6&db=m Activation of a K+ conductance by bradykinin and by inositol-1,4,5-trisphosphate in rat glioma cells: involvement of intracellular and extracellular Ca2+. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2434833&form=6&db=m Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438697&form=6&db=m Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2466693&form=6&db=m Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line Jurkat. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2469642&form=6&db=m Interactive effects of pertussis toxin and the phorbol ester tumour promotor, phorbol dibutyrate, on T-lymphocyte mitogenesis and the expression of phenotypic determinants. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2499681&form=6&db=m Signal-transducing GTP-binding proteins of mammalian heart and lungs. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2518286&form=6&db=m Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2530240&form=6&db=m Vasopressin rapidly stimulates protein kinase C in digitonin-permeabilized Swiss 3T3 cells: involvement of a pertussis toxin-insensitive guanine nucleotide binding protein. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2537359&form=6&db=m Studies on molecular regulation of phagocytosis in neutrophils. Con A-mediated ingestion and associated respiratory burst independent of phosphoinositide turnover, rise in [Ca2+]i, and arachidonic acid release. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539969&form=6&db=m Effects of pertussis toxin on resorption of 19-day-old fetal rat long bones. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541005&form=6&db=m Regulation of glucose transport by insulin, bombesin, and bradykinin in Swiss 3T3 fibroblasts: involvement of protein kinase C-dependent and -independent mechanisms. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2551506&form=6&db=m Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2552724&form=6&db=m Effects of protein kinase C activation on cyclic AMP and testosterone production of rat Leydig cells in vitro. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557347&form=6&db=m The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569396&form=6&db=m Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2732469&form=6&db=m Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C. diagnostic usage,ongoing research,unassigned 2,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2746325&form=6&db=m Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2787778&form=6&db=m Effect of protein kinase C inhibitor (H-7) and calmodulin antagonist (W-7) on pertussis toxin-induced IL-1 production by human adherent monocytes. Comparison with lipopolysaccharide as a stimulator of IL-1 production. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820995&form=6&db=m Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833889&form=6&db=m Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835989&form=6&db=m Cytoplasmic pH change induced by leukotriene B4 in human neutrophils. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2848040&form=6&db=m Bombesin enhancement of cAMP accumulation in Swiss 3T3 cells: evidence of a dual mechanism of action. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849940&form=6&db=m Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2876983&form=6&db=m Protein kinase C enhances growth hormone releasing factor (1-40)-stimulated cyclic AMP levels in anterior pituitary. Actions of somatostatin and pertussis toxin. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2956893&form=6&db=m Inhibition of epithelial Na+ transport by atriopeptin, protein kinase c, and pertussis toxin. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2983701&form=6&db=m Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: role of the "G proteins" in stimulus-response coupling. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997705&form=6&db=m Calcium mobilization and signal transduction in the neutrophils. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3017756&form=6&db=m Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031676&form=6&db=m Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3039979&form=6&db=m Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3083411&form=6&db=m Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115832&form=6&db=m Induction of c-fos proto-oncogene by a chemotactic peptide in human peripheral granulocytes. ongoing research,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115980&form=6&db=m Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3348814&form=6&db=m Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3816821&form=6&db=m The role of the cytosolic free Ca2+ transient for fMet-Leu-Phe induced actin polymerization in human neutrophils. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7489830&form=6&db=m Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7503257&form=6&db=m Adenosine A1 receptor-induced upregulation of protein kinase C: role of pertussis toxin-sensitive G protein(s). therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7503720&form=6&db=m Endothelin-1 induces rapid and long lasting internalization of the thrombin receptor in human glomerular epithelial cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7515926&form=6&db=m Tyrosine phosphorylation in activated human neutrophils. Comparison of the effects of different classes of agonists and identification of the signaling pathways involved. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7526867&form=6&db=m Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7554210&form=6&db=m Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7582524&form=6&db=m Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptors. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592645&form=6&db=m Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615808&form=6&db=m Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7637260&form=6&db=m Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7681476&form=6&db=m Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7694506&form=6&db=m Endothelin B receptor mediates ET-1 effects on cAMP and PGE2 accumulation in rat IMCD. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7741705&form=6&db=m Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of mitogen-activated protein kinase by protein kinase C- and pertussis toxin-dependent pathways in the endothelial cell line EAhy 926. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7753758&form=6&db=m Effects of zinc on production of active oxygen species by rat neutrophils. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7806133&form=6&db=m Effect of retinoic acid on prostaglandin F2 alpha-induced prostaglandin E2 synthesis in osteoblast-like cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813633&form=6&db=m Lysophosphatidic acid induction of transforming growth factors alpha and beta: modulation of proliferation and differentiation in cultured human keratinocytes and mouse skin. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7857772&form=6&db=m Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7867605&form=6&db=m Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7884461&form=6&db=m Differences between presynaptic and postsynaptic GABAB mechanisms in rat hippocampal pyramidal cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7904711&form=6&db=m Adenosine 5'-triphosphate, phorbol ester, and pertussis toxin effects on atrial natriuretic peptide stimulation of guanylate cyclase in a human renal cell line. ongoing research,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7929124&form=6&db=m Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensin II. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943843&form=6&db=m Halothane inhibits bradykinin-stimulated prostacyclin production in endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945264&form=6&db=m Pancreastatin activates protein kinase C by stimulating the formation of 1,2-diacylglycerol in rat hepatocytes. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7965816&form=6&db=m L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7977702&form=6&db=m Effects of prostaglandin E2 on amiloride-blockable Na+ channels in a distal nephron cell line (A6). unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7978880&form=6&db=m Heterotrimeric G proteins involved in the modulation of voltage-dependent calcium channels of neuroendocrine cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7980611&form=6&db=m Endothelin-1 activates mitogen-activated protein kinases through two independent signalling pathways in rat astrocytes. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981246&form=6&db=m Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C. causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982455&form=6&db=m Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982904&form=6&db=m Retinoic acid-induced gene expression of tissue transglutaminase via protein kinase C-dependent pathway in mouse peritoneal macrophages. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8004062&form=6&db=m Stimulation of reactive oxidant production in neutrophils by soluble and insoluble immune complexes occurs via different receptors/signal transduction systems. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8034731&form=6&db=m Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8046455&form=6&db=m Augmentation of calcium channel currents in response to G protein activation by GTP gamma S in chick sensory neurons. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8048563&form=6&db=m Prostaglandins mediate the defect in AVP-stimulated cAMP generation in immature collecting duct. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8088367&form=6&db=m Functional characterization of the Na(+)-H+ exchanger in rat mast cells: crosstalks between different kinase pathways. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8094958&form=6&db=m Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine kinase inhibitors. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137877&form=6&db=m Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8192649&form=6&db=m Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C. causal interaction,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8205654&form=6&db=m Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8223859&form=6&db=m Stimulation of the intracellular killing of Staphylococcus aureus by human monocytes mediated by Fc gamma receptors I and II. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224610&form=6&db=m Lysophosphatidic acid mimics serum-induced sensitization of cyclic AMP accumulation. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8271267&form=6&db=m Mobilization of intracellular calcium in cultured vascular smooth muscle cells by uridine triphosphate and the calcium ionophore A23187. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294438&form=6&db=m Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294914&form=6&db=m Guinea pig histamine H1 receptor. II. Stable expression in Chinese hamster ovary cells reveals the interaction with three major signal transduction pathways. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8294922&form=6&db=m Endothelin-1 receptor binding and cellular signal transduction in cultured human brain endothelial cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8299148&form=6&db=m Assembly dynamics of actin in adherent human neutrophils. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8308742&form=6&db=m Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8313982&form=6&db=m Alpha 2A-adrenergic receptors activate protein kinase C in human platelets via a pertussis toxin-sensitive G-protein. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383803&form=6&db=m Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8384085&form=6&db=m Human monocytes respond to leukotriene B4 with a transient increase in cytosolic calcium. causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388325&form=6&db=m Dual effect of thrombin on voltage-dependent Ca2+ channels of portal vein smooth muscle cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391006&form=6&db=m Mechanism and regulation of neutrophil priming by platelet-activating factor. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8397045&form=6&db=m Further characterization of 5-HT- and 5-HT3 receptor agonists'-stimulated phosphoinositol phosphates accumulation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8418894&form=6&db=m Strontium and barium induce exocytosis in electropermeabilized neutrophils. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8476075&form=6&db=m Transforming growth factor-beta inhibits phosphate transport in renal epithelial cells. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8500137&form=6&db=m Calcium mobilization and cell proliferation activated by extracellular ATP in human ovarian tumour cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8521911&form=6&db=m Multiple mechanisms of bradykinin-induced contraction in rat and guinea pig smooth muscles in vitro. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8546817&form=6&db=m Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8549792&form=6&db=m Adenosine evokes potassium currents by protein kinase C activated via a novel signaling pathway in superior colliculus neurons. causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595929&form=6&db=m A comparison of the effects of signal transduction inhibitors on oxidative burst and degranulation in IL-I beta stimulated bovine neutrophils. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626494&form=6&db=m Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636412&form=6&db=m Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647116&form=6&db=m Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8690152&form=6&db=m Lithium stimulation of rat pancreatic beta-cell replication is mediated through pertussis toxin-sensitive GTP-binding proteins and occurs independently of Ca2+ influx, cAMP, or protein kinase C activation. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8691134&form=6&db=m Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8726354&form=6&db=m Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8759101&form=6&db=m Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8765040&form=6&db=m Human eotaxin represents a potent activator of the respiratory burst of human eosinophils. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777144&form=6&db=m Pancreastatin action in the liver: dual coupling to different G proteins. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8798377&form=6&db=m G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8846514&form=6&db=m Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8861537&form=6&db=m Modulation of islet G-proteins, alpha-glucosidehydrolase inhibition and insulin release stimulated by various secretagogues. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8863847&form=6&db=m Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8878121&form=6&db=m Secretoneurin-induced in vitro chemotaxis of human monocytes is inhibited by pertussis toxin and an inhibitor of protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8887991&form=6&db=m Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8901512&form=6&db=m Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8931111&form=6&db=m Effect of retinoic acid on prostaglandin F2 alpha-induced phospholipase D activity in osteoblast-like cells. causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8947479&form=6&db=m Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994056&form=6&db=m Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9001889&form=6&db=m Mechanism of induction of prostaglandin E2 production by endothelin 1 in cultured rat mesangial cells. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9017600&form=6&db=m Role of gelsolin in actin depolymerization of adherent human neutrophils. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9038193&form=6&db=m Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9124373&form=6&db=m Muscarinic-induced mucin secretion and intracellular signaling by hamster tracheal goblet cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9138685&form=6&db=m Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9153259&form=6&db=m Chemoattractant receptor-induced phosphorylation of L-selectin. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9167640&form=6&db=m G proteins and phospholipase C mediate thrombin-induced generation of plasminogen activator inhibitor-1 from vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9192782&form=6&db=m Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9237867&form=6&db=m Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9271339&form=6&db=m Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9292539&form=6&db=m Lipoprotein(a) is a potent chemoattractant for human peripheral monocytes. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9322911&form=6&db=m Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9322919&form=6&db=m The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9340579&form=6&db=m [Intracellular signal transmission of low density lipoprotein receptors in human monocytes] unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9357768&form=6&db=m Regulation of vascular angiotensin II receptors by EGF. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443926&form=6&db=m Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9489755&form=6&db=m Nociceptin/orphanin FQ activates mitogen-activated protein kinase in Chinese hamster ovary cells expressing opioid receptor-like receptor. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9563629&form=6&db=m Signaling pathways for tissue factor expression in lipopolysaccharide-stimulated bovine alveolar macrophages. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9576877&form=6&db=m Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9579636&form=6&db=m Transcellular signaling and pharmacological modulation of thrombin-induced production of plasminogen activator inhibitor-1 in vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9590266&form=6&db=m Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway. causal interaction,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9612296&form=6&db=m Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9614143&form=6&db=m Regulation of alphaIIb beta3 function in human B lymphocytes. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9614219&form=6&db=m Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9670207&form=6&db=m Transforming growth factor-beta-mediated proliferation of renal tubular epithelial cells involves pertussis toxin-sensitive G protein-and protein kinase C-dependent pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9670847&form=6&db=m Similar involvement of VIP receptor type I and type II in lymphocyte chemotaxis. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9677414&form=6&db=m The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679179&form=6&db=m Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679984&form=6&db=m Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1. causal interaction,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9711351&form=6&db=m Pertussis toxin modification of PC12 cells lowers cytoskeletal F-actin and enhances norepinephrine secretion: involvement of protein kinase C and protein phosphatases. ongoing research,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9712151&form=6&db=m SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9728323&form=6&db=m Contribution of cAMP to the inhibitory effect of non-steroidal anti-inflammatory drugs in rat uterine smooth muscle. ongoing research,therapeutic application,unassigned 1,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731750&form=6&db=m Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9767536&form=6&db=m Mechanisms through which high glucose concentration raises [Ca2+]i in renal proximal tubular cells. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9843907&form=6&db=m Prostanoid signaling, localization, and expression of IP receptors in rat thick ascending limb cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888523&form=6&db=m Duality of the voltage-dependent calcium influx in adrenal glomerulosa cells. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9920937&form=6&db=m Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927281&form=6&db=m Activation of protein kinase C by oxytocin inhibits the biological activity of the human myometrial corticotropin-releasing hormone receptor at term. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10030845&form=6&db=m Pertussis toxin-induced lung edema. Role of manganese superoxide dismutase and protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067866&form=6&db=m Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells: roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10071781&form=6&db=m Angiotensin II type 1 receptor activation modulates L- and T-type calcium channel activity through distinct mechanisms in bovine adrenal glomerulosa cells. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10190149&form=6&db=m [The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria] ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196148&form=6&db=m Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10342794&form=6&db=m Lysophosphatidic acid stimulates protein kinase C isoforms alpha, beta, epsilon, and zeta in a pertussis toxin sensitive pathway in vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391918&form=6&db=m Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411794&form=6&db=m Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygenase-2 and prostaglandin production in human myometrial cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419564&form=6&db=m Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499523&form=6&db=m Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10536119&form=6&db=m Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10559239&form=6&db=m Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579343&form=6&db=m Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10598016&form=6&db=m High concentrations of histamine stimulate equine polymorphonuclear neutrophils to produce reactive oxygen species. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640689&form=6&db=m Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10646507&form=6&db=m Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10670413&form=6&db=m The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678742&form=6&db=m Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683250&form=6&db=m Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10712420&form=6&db=m Ras/Rac-Dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748000&form=6&db=m Rapid Ca2+ influx and diacylglycerol synthesis in growth hormone-mediated islet beta -cell mitogenesis. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762352&form=6&db=m Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10771099&form=6&db=m Transforming growth factor-beta1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779388&form=6&db=m Lysophosphatidic acid modulates alpha(1b)-adrenoceptor phosphorylation and function: roles of Gi and phosphoinositide 3-kinase. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10788502&form=6&db=m Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10810292&form=6&db=m Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10817567&form=6&db=m Soluble vascular cell adhesion molecule 1 mediation of monocyte chemotaxis in rheumatoid arthritis. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10843712&form=6&db=m Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. causal interaction,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864142&form=6&db=m The upstream regulation of p38 mitogen-activated protein kinase phosphorylation by arachidonic acid in rat neutrophils. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10869343&form=6&db=m Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899923&form=6&db=m Muscarinic activation of mitogen-activated protein kinase in PC12 cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10900259&form=6&db=m Inhibition of alpha(1)-adrenergic-mediated responses in rat ventricular myocytes by adenosine A(1) receptor activation: role of the K(ATP) channel. ongoing research,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10921922&form=6&db=m Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10967560&form=6&db=m Membrane signalling and progesterone in female and male osteoblasts. I. Involvement Of intracellular Ca(2+), inositol trisphosphate, and diacylglycerol, but not cAMP. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11003574&form=6&db=m Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11007893&form=6&db=m Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11054382&form=6&db=m Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062237&form=6&db=m N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11068150&form=6&db=m Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11084020&form=6&db=m Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158213&form=6&db=m Protein kinase C and G(i/o) proteins are involved in adenosine- and ischemic preconditioning-mediated renal protection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160627&form=6&db=m The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal growth factor receptor. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162186&form=6&db=m Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170183&form=6&db=m Pertussis toxin-sensitive G-protein and protein kinase C activity are involved in normal synapse elimination in the neonatal rat muscle. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179453&form=6&db=m Angiotensin AT(1) receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase c and phosphoinositide 3-kinase. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208605&form=6&db=m Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11243883&form=6&db=m Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid. ongoing research,therapeutic application,unassigned 2,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11256956&form=6&db=m Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278760&form=6&db=m Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287337&form=6&db=m Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306682&form=6&db=m Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312566&form=6&db=m Regeneration of entorhinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF, and modulators of G-proteins and protein kinase C. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369000&form=6&db=m Involvement of MAP kinases in the control of cPLA(2) and arachidonic acid release in endothelial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375998&form=6&db=m beta-Migrating very low density lipoprotein (beta VLDL) activates smooth muscle cell mitogen-activated protein (MAP) kinase via G protein-coupled receptor-mediated transactivation of the epidermal growth factor (EGF) receptor: effect of MAP kinase activation on beta VLDL plus EGF-induced cell proliferation. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384838&form=6&db=m Platelet-derived growth factor mediated altered expression and regulation of ornithine decarboxylase in H-ras-transformed cell lines. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11455205&form=6&db=m Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11466206&form=6&db=m Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11472785&form=6&db=m Signal transduction pathways activated by engaging immunoglobulin Fc receptors on chicken heterophils. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11476154&form=6&db=m Activation of human neutrophils by chlordane: induction of superoxide production and phagocytosis but not chemotaxis or apoptosis. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509538&form=6&db=m Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11682614&form=6&db=m Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11758972&form=6&db=m Regulation of gadd153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11825890&form=6&db=m The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11834242&form=6&db=m Involvement of Rho and tyrosine kinase in angiotensin II-induced actin reorganization in mesothelial cells. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934694&form=6&db=m Adenosine attenuates oxidant injury in human proximal tubular cells via A(1) and A(2a) adenosine receptors. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934705&form=6&db=m alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11934810&form=6&db=m Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11970732&form=6&db=m Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11982820&form=6&db=m Cell apoptosis and hemodialysis-induced inflammation. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12013509&form=6&db=m Gi-mediated activation of the p42/p44 mitogen-activated protein kinases by receptor mimetic basic secretagogues is abrogated by inhibitors of endocytosis. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12039983&form=6&db=m MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060491&form=6&db=m In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065629&form=6&db=m GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12067898&form=6&db=m Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12099721&form=6&db=m Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12194965&form=6&db=m Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204793&form=6&db=m D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217860&form=6&db=m Localization of IP in rabbit kidney and functional role of the PGI(2)/IP system in cortical collecting duct. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12244165&form=6&db=m Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12356790&form=6&db=m Priming by grepafloxacin on respiratory burst of human neutrophils: its possible mechanism. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12556526&form=6&db=m Mastoparan selectively activates phospholipase D2 in cell membranes. ongoing research,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559089&form=6&db=m Rapid inhibitory effects of corticosterone on calcium influx in rat dorsal root ganglion neurons. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560086&form=6&db=m Sphingosine-1-phosphate stimulates cortisol secretion. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560106&form=6&db=m D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12579890&form=6&db=m [Effects of praeruptorin C on cell hypertrophy, intracellular [Ca2+]i, nitric oxide and signal transduction in isolated hypertrophied rat smooth muscle cells induced by angiotensin II] therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616990&form=6&db=m Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637559&form=6&db=m High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12639714&form=6&db=m Interleukin-8 production induced by the endozepine triakontatetraneuropeptide in human neutrophils: role of calcium and pharmacological investigation of signal transduction pathways. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12650862&form=6&db=m Nongenomic mechanism of glucocorticoid inhibition of bradykinin-induced calcium influx in PC12 cells: possible involvement of protein kinase C. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665564&form=6&db=m Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12716436&form=6&db=m Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12717674&form=6&db=m [Kainate receptors. Their function in the regulation of GABAergic synaptic transmission in the hippocampus] therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12742228&form=6&db=m Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795614&form=6&db=m Mitogen-induced activation of Na+/H+ exchange in vascular smooth muscle cells involves janus kinase 2 and Ca2+/calmodulin. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12865333&form=6&db=m Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12880866&form=6&db=m Lysophosphatidic acid induces alpha1B-adrenergic receptor phosphorylation through G beta gamma, phosphoinositide 3-kinase, protein kinase C and epidermal growth factor receptor transactivation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895426&form=6&db=m Noncanonical signaling by ionotropic kainate receptors. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12950721&form=6&db=m Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14519448&form=6&db=m Direct and biochemical interaction between dopamine D3 receptor and elongation factor-1Bbetagamma. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521590&form=6&db=m Thrombin induces neoangiogenesis in the chick chorioallantoic membrane. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14527175&form=6&db=m Differential activation of signal transduction pathways mediating oxidative burst by chicken heterophils in response to stimulation with lipopolysaccharide and lipoteichoic acid. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14648542&form=6&db=m Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14695118&form=6&db=m Pertussis toxin activates L-arginine uptake in pulmonary endothelial cells through downregulation of PKC-alpha activity. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729379&form=6&db=m Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14975703&form=6&db=m Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159403&form=6&db=m Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15164168&form=6&db=m Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15450921&form=6&db=m Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632122&form=6&db=m Long lasting inhibition of adenylyl cyclase selectively mediated by inositol 1,4,5-trisphosphate-evoked calcium release. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15733090&form=6&db=m Coupling of 5-HT1A autoreceptors to inhibition of mitogen-activated protein kinase activation via G beta gamma subunit signaling. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15764707&form=6&db=m A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15794661&form=6&db=m Proteolytic activation of protein kinase Calpha by peroxynitrite in stimulating cytosolic phospholipase A2 in pulmonary endothelium: involvement of a pertussis toxin sensitive protein. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817447&form=6&db=m Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. causal interaction,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817833&form=6&db=m Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15862293&form=6&db=m Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15934932&form=6&db=m Presynaptic inhibition of transmitter release from rat sympathetic neurons by bradykinin. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025745&form=6&db=m Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052566&form=6&db=m Cross-talk among epidermal growth factor, Ap(5)A, and nucleotide receptors causing enhanced ATP Ca(2+) signaling involves extracellular kinase activation in cerebellar astrocytes. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081051&form=6&db=m Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16125525&form=6&db=m Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16148159&form=6&db=m Differential calcium regulation of proinflammatory activities in human neutrophils exposed to the neuropeptide pituitary adenylate cyclase-activating protein. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16271370&form=6&db=m Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16291515&form=6&db=m Oxidant-mediated activation of cytosolic phospholipase a(2) in pulmonary endothelium: role of protein kinase C alpha and a pertussis toxin-sensitive protein. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407557&form=6&db=m Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16554657&form=6&db=m Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. ongoing research,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16569707&form=6&db=m Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16647694&form=6&db=m Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP. causal interaction,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16803866&form=6&db=m Insulin-like growth factor-I induces alpha(1B)-adrenergic receptor phosphorylation through G beta gamma and epidermal growth factor receptor transactivation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16888186&form=6&db=m Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils. ongoing research,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16934753&form=6&db=m Mechanism of isoproterenol-induced RGS2 up-regulation in astrocytes. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16988058&form=6&db=m Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17014689&form=6&db=m Modulation of melatonin receptors and G-protein function by microtubules. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17038637&form=6&db=m Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130674&form=6&db=m Contribution of extracellular signal-regulated kinase to UTP-induced interleukin-6 biosynthesis in HaCaT keratinocytes. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369456&form=6&db=m A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17606321&form=6&db=m Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17650109&form=6&db=m mGluR7 inhibits glutamate release through a PKC-independent decrease in the activity of P/Q-type Ca2+ channels and by diminishing cAMP in hippocampal nerve terminals. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707940&form=6&db=m Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17915215&form=6&db=m Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18093742&form=6&db=m Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097625&form=6&db=m Molecular events involved in the increased expression of matrix metalloproteinase-9 by T lymphocytes of mammary tumor-bearing mice. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18211822&form=6&db=m Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18311185&form=6&db=m Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18365868&form=6&db=m Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367611&form=6&db=m Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18386288&form=6&db=m Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577183&form=6&db=m Ghrelin signalling in guinea-pig femoral artery smooth muscle cells. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021033&form=6&db=m Prolactin induced production of cytokines in macrophages involves Ca++ and p42/44 MAP kinase signaling pathway. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19275929&form=6&db=m Activation of G(i) induces mechanical hyperalgesia poststress or inflammation. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409890&form=6&db=m Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447154&form=6&db=m The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19669929&form=6&db=m Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885020&form=6&db=m P2 Receptor-mediated Inhibition of Vasopressin-stimulated Fluid Transport and cAMP Responses in AQP2-transfected MDCK Cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912854&form=6&db=m PKC modulation of inhibitory coupling of angiotensin II receptors with adenylate cyclase in lactotroph cells. causal interaction,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20222145&form=6&db=m Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in primary astrocytes. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21258176&form=6&db=m Involvement of protein kinase C and RhoA in protease-activated receptor 1-mediated F-actin reorganization and cell growth in rat cardiomyocytes. therapeutic application,unassigned 3,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21329754&form=6&db=m Activation of M3 muscarinic receptors inhibits T-type Ca(2+) channel currents via pertussis toxin-sensitive novel protein kinase C pathway in small dorsal root ganglion neurons. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21338628&form=6&db=m Molecular determinants and feedback circuits regulating type 2 CRH receptor signal integration. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21419195&form=6&db=m Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate tetralithium and 2-methylthioadenosine-5'-diphosphate trisodium: mechanisms involved. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21562303&form=6&db=m Calcium-sensing receptor modulates extracellular Ca2+ entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21566946&form=6&db=m Muscarinic acetylcholine and histamine-receptor mediated calcium mobilization and cell-growth in human ovarian-cancer cells. causal interaction,ongoing research,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21691079&form=6&db=m Activation of growth hormone secretagogue type 1a receptor inhibits T-type Ca2+ channel currents through pertussis toxin-sensitive novel protein kinase C pathway in mouse spermatogenic cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21851339&form=6&db=m 5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21936876&form=6&db=m Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22031472&form=6&db=m ?-Opioid receptors stimulate the metabolic sensor AMP-activated protein kinase through coincident signaling with G(q/11)-coupled receptors. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23179589&form=6&db=m Rapid elevation of calcium concentration in cultured dorsal spinal cord astrocytes by corticosterone. therapeutic application,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396229&form=6&db=m Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23556457&form=6&db=m Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24145616&form=6&db=m Lysophosphatidic acid activates ?-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24385109&form=6&db=m High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819773&form=6&db=m Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. therapeutic application,unassigned 4,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28095239&form=6&db=m Evidence for a cyclic AMP-dependent pathway in angiotensin AT1-receptor activation of human omental arteries. therapeutic application,unassigned 2,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31941716&form=6&db=m Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. unassigned - 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32222457&form=6&db=m Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2. ongoing research,unassigned 1,0 2.7.11.13 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32272531&form=6&db=m Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes. therapeutic application,unassigned 3,0 2.7.11.13 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16460447&form=6&db=m A role for PKCtheta in outside-in alphabeta signaling. unassigned - 2.7.11.13 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19805632&form=6&db=m Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension. ongoing research,unassigned 2,0 2.7.11.13 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570449&form=6&db=m Role of Rho-GTPases in megakaryopoiesis. ongoing research,unassigned 2,0 2.7.11.13 Zellweger Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8892024&form=6&db=m Protein kinase C activity, phosphate uptake and endogenous substrate phosphorylation are altered in Zellweger syndrome. diagnostic usage,unassigned 3,0 2.7.11.13 Zellweger Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639664&form=6&db=m Phospholipase D activity is altered in X-linked adrenoleukodystrophy heterozygous carriers, but not in hemizygous patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0