2.7.11.12 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33468473&form=6&db=m Deletion of pknG Abates Reactivation of Latent Mycobacterium tuberculosis in Mice. causal interaction,unassigned 4,0 2.7.11.12 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269222&form=6&db=m Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561748&form=6&db=m Killing me softly - suicidal erythrocyte death. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23801921&form=6&db=m Physiology and pathophysiology of eryptosis. causal interaction,unassigned 2,0 2.7.11.12 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12777700&form=6&db=m Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.12 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770022&form=6&db=m Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28363452&form=6&db=m An algorithm for direct causal learning of influences on patient outcomes. ongoing research,unassigned 1,0 2.7.11.12 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269222&form=6&db=m Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561748&form=6&db=m Killing me softly - suicidal erythrocyte death. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23801921&form=6&db=m Physiology and pathophysiology of eryptosis. causal interaction,unassigned 2,0 2.7.11.12 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269222&form=6&db=m Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561748&form=6&db=m Killing me softly - suicidal erythrocyte death. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23801921&form=6&db=m Physiology and pathophysiology of eryptosis. causal interaction,unassigned 2,0 2.7.11.12 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23910461&form=6&db=m Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections. causal interaction,unassigned 4,0 2.7.11.12 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30577811&form=6&db=m Exome sequencing reveals a de novo PRKG1 mutation in a sporadic patient with aortic dissection. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30871887&form=6&db=m The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln). causal interaction,unassigned 3,0 2.7.11.12 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32199657&form=6&db=m Aortic progression and reintervention in patients with pathogenic variants after a thoracic aortic dissection. unassigned - 2.7.11.12 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23910461&form=6&db=m Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections. causal interaction,unassigned 4,0 2.7.11.12 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29510914&form=6&db=m Testing patterns for genetically triggered aortic and arterial aneurysms and dissections at an academic center. diagnostic usage,unassigned 2,0 2.7.11.12 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087447&form=6&db=m Association of modifiers and other genetic factors explain Marfan syndrome clinical variability. unassigned - 2.7.11.12 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30871887&form=6&db=m The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln). causal interaction,unassigned 3,0 2.7.11.12 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506052&form=6&db=m A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.12 Aortic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23910461&form=6&db=m Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections. causal interaction,unassigned 4,0 2.7.11.12 Aortic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27442293&form=6&db=m PRKG1 and genetic diagnosis of early-onset thoracic aortic disease. causal interaction,diagnostic usage,unassigned 1,4,0 2.7.11.12 Aortic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30577811&form=6&db=m Exome sequencing reveals a de novo PRKG1 mutation in a sporadic patient with aortic dissection. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Aortic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506052&form=6&db=m A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.7.11.12 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851947&form=6&db=m Single Nucleotide Polymorphisms (SNPs) in PRKG1 & SPATA13-AS1 are associated with bronchodilator response: a pilot study during acute asthma exacerbations in African American children. causal interaction,unassigned 1,0 2.7.11.12 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10974414&form=6&db=m Transplant atherosclerosis: role of phenotypic modulation of vascular smooth muscle by nitric oxide. causal interaction,unassigned 1,0 2.7.11.12 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14645134&form=6&db=m Regulation of gene expression by cyclic GMP. unassigned - 2.7.11.12 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24921837&form=6&db=m cGMP and cGMP-Dependent Protein Kinase I Pathway in Dorsal Root Ganglia Contributes to Bone Cancer Pain in Rats. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.12 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533140&form=6&db=m Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro. therapeutic application,unassigned 1,0 2.7.11.12 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17564679&form=6&db=m The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes. causal interaction,unassigned 1,0 2.7.11.12 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543319&form=6&db=m Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.7.11.12 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996273&form=6&db=m Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. ongoing research,unassigned 3,0 2.7.11.12 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21777390&form=6&db=m Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.12 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22095901&form=6&db=m Induction of apoptosis by type I? protein kinase G in the human breast cancer cell lines MCF-7 and MDA-MB-468. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 2.7.11.12 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427012&form=6&db=m Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.12 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22791569&form=6&db=m Expression of cGMP-dependent protein kinase, PKGI?, PKGI?, and PKGII in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 2.7.11.12 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23418348&form=6&db=m cGMP-dependent Protein Kinase I? Regulates Breast Cancer Cell Migration and Invasion via a Novel Interaction with the Actin/Myosin-associated Protein Caldesmon. therapeutic application,unassigned 1,0 2.7.11.12 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25724429&form=6&db=m The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression. causal interaction,unassigned 3,0 2.7.11.12 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12777700&form=6&db=m Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.12 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7543493&form=6&db=m Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.12 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11600145&form=6&db=m Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells. ongoing research,unassigned 4,0 2.7.11.12 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256267&form=6&db=m An anti-tumor role for cGMP-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.12 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15582712&form=6&db=m eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells. ongoing research,unassigned 4,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=210840&form=6&db=m Alterations in activities of cyclic nucleotide systems and in beta-adrenergic receptor-mediated activation of cyclic AMP-dependent protein kinase during progression and regression of isoproterenol-induced cardiac hypertrophy. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855709&form=6&db=m Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction. therapeutic application,unassigned 1,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14645134&form=6&db=m Regulation of gene expression by cyclic GMP. unassigned - 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15813973&form=6&db=m Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T. therapeutic application,unassigned 1,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029137&form=6&db=m Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway. therapeutic application,unassigned 3,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19255346&form=6&db=m Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. unassigned - 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19719752&form=6&db=m B-type natriuretic peptide attenuates cardiac hypertrophy via TGF-beta1/smad7 pathway in vivo and in vitro. diagnostic usage,unassigned 3,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20177073&form=6&db=m Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition. therapeutic application,unassigned 2,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20212138&form=6&db=m Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22750195&form=6&db=m Regression of pathological cardiac hypertrophy: Signaling pathways and therapeutic targets. unassigned - 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24948380&form=6&db=m Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond. therapeutic application,unassigned 1,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139994&form=6&db=m Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25547873&form=6&db=m Murine cardiac growth, TRPC channels, and cGMP kinase I. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25747598&form=6&db=m The Emperor's New Clothes: PDE5 and the Heart. therapeutic application,unassigned 1,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26269433&form=6&db=m Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27581840&form=6&db=m Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways. ongoing research,unassigned 2,0 2.7.11.12 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31123275&form=6&db=m Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34000062&form=6&db=m Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. causal interaction,unassigned 2,0 2.7.11.12 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22199120&form=6&db=m Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I. ongoing research,unassigned 2,0 2.7.11.12 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507050&form=6&db=m Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. causal interaction,unassigned 3,0 2.7.11.12 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448676&form=6&db=m High blood pressure arising from a defect in vascular function. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406699&form=6&db=m Adenosine analogue-oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIalpha). causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.12 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33788443&form=6&db=m [Effects of electroacupuncture "Shuigou" on expression of soluble guanylate cyclase(sGC) and protein kinase G (PKG)in vascular smooth muscle of cerebral artery in rats with cerebral infarction]. ongoing research,unassigned 1,0 2.7.11.12 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8230323&form=6&db=m Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia. therapeutic application,unassigned 3,0 2.7.11.12 cgmp-dependent protein kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973199&form=6&db=m Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.12 cgmp-dependent protein kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551195&form=6&db=m Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. causal interaction,unassigned 4,0 2.7.11.12 cgmp-dependent protein kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19156199&form=6&db=m cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness. causal interaction,unassigned 3,0 2.7.11.12 cgmp-dependent protein kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22632818&form=6&db=m Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14988827&form=6&db=m Guanylin regulates chloride secretion in the human gallbladder via the bile fluid. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.12 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329520&form=6&db=m Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP. ongoing research,unassigned 2,0 2.7.11.12 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2560108&form=6&db=m Inhibition by the protein kinase inhibitors, isoquinolinesulfonamides, of fluid accumulation induced by Escherichia coli heat-stable enterotoxin, 8-bromo-cGMP and 8-bromo-cAMP in suckling mice. unassigned - 2.7.11.12 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10997924&form=6&db=m Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells. therapeutic application,unassigned 1,0 2.7.11.12 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12028130&form=6&db=m Regulation of apical transporter of L-DOPA in human intestinal Caco-2 cells. therapeutic application,unassigned 1,0 2.7.11.12 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28057484&form=6&db=m Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells. ongoing research,unassigned 2,0 2.7.11.12 Coccidiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11897122&form=6&db=m Molecular characterization of a coccidian parasite cGMP dependent protein kinase. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.12 Coccidiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15844962&form=6&db=m Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Coccidiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16643061&form=6&db=m Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278263&form=6&db=m Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. therapeutic application,unassigned 4,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12392815&form=6&db=m Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation. causal interaction,unassigned 3,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12699056&form=6&db=m Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15173009&form=6&db=m Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166323&form=6&db=m Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731751&form=6&db=m Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18163459&form=6&db=m Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20348951&form=6&db=m PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. therapeutic application,unassigned 1,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22556146&form=6&db=m Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998725&form=6&db=m cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. ongoing research,unassigned 4,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849123&form=6&db=m Type II cGMP?dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.12 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29028532&form=6&db=m New dimeric cGMP analogues reduce proliferation in three colon cancer cell lines. unassigned - 2.7.11.12 Color Vision Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33374621&form=6&db=m The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.12 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18269345&form=6&db=m Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.7.11.12 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24217248&form=6&db=m Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. ongoing research,unassigned 3,0 2.7.11.12 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9468213&form=6&db=m Role of endothelin-A receptors in ischemic contracture and reperfusion injury. therapeutic application,unassigned 1,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7543493&form=6&db=m Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592887&form=6&db=m Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8636133&form=6&db=m N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9020133&form=6&db=m cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9465038&form=6&db=m Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671794&form=6&db=m Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9755058&form=6&db=m Cl- transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon. unassigned - 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10769198&form=6&db=m Rising behind NO: cGMP-dependent protein kinases. unassigned - 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864932&form=6&db=m The amino-terminal cyclic nucleotide binding site of the type II cGMP-dependent protein kinase is essential for full cyclic nucleotide-dependent activation. therapeutic application,unassigned 4,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208062&form=6&db=m Microvillus inclusion disease: a genetic defect affecting apical membrane protein traffic in intestinal epithelium. diagnostic usage,unassigned 2,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11596856&form=6&db=m Guanylin and related peptides. unassigned - 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011439&form=6&db=m Clara cell impact in air-side activation of CFTR in small pulmonary airways. unassigned - 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14986129&form=6&db=m Ontogeny of guanylin-immunoreactive cells in rat salivary glands. therapeutic application,unassigned 1,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17643962&form=6&db=m The alpha2beta1 isoform of guanylyl cyclase mediates plasma membrane localized nitric oxide signalling. ongoing research,unassigned 2,0 2.7.11.12 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481254&form=6&db=m Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. unassigned - 2.7.11.12 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698857&form=6&db=m Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. unassigned - 2.7.11.12 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32270922&form=6&db=m Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. unassigned - 2.7.11.12 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23876037&form=6&db=m West Nile virus methyltransferase domain interacts with protein kinase G. therapeutic application,unassigned 4,0 2.7.11.12 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507050&form=6&db=m Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. causal interaction,unassigned 3,0 2.7.11.12 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194177&form=6&db=m Expression and distribution of cyclic GMP-dependent protein kinase-1 isoforms in human penile erectile tissue. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684677&form=6&db=m A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. causal interaction,unassigned 1,0 2.7.11.12 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773997&form=6&db=m Bioactive compounds in plant materials for the prevention of diabetesand obesity. unassigned - 2.7.11.12 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34221234&form=6&db=m Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLC?1-Ca2+-Mediated Endoplasmic Reticulum Stress. therapeutic application,unassigned 1,0 2.7.11.12 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29301852&form=6&db=m Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.12 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773997&form=6&db=m Bioactive compounds in plant materials for the prevention of diabetesand obesity. unassigned - 2.7.11.12 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34221234&form=6&db=m Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLC?1-Ca2+-Mediated Endoplasmic Reticulum Stress. therapeutic application,unassigned 1,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8953039&form=6&db=m Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12193576&form=6&db=m Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15775313&form=6&db=m [Natriuretic peptides as novel growth factor of growth plate cartilage] ongoing research,unassigned 3,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838621&form=6&db=m Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes. causal interaction,unassigned 2,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551195&form=6&db=m Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. causal interaction,unassigned 4,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19149413&form=6&db=m Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887637&form=6&db=m A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle. ongoing research,unassigned 1,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25924610&form=6&db=m Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.12 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28697878&form=6&db=m Current insights into the molecular genetic basis of dwarfism in livestock. causal interaction,unassigned 3,0 2.7.11.12 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15827295&form=6&db=m In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOS II/peroxynitrite cascade. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.12 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587280&form=6&db=m Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.12 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587280&form=6&db=m Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.12 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10688876&form=6&db=m Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.12 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11428344&form=6&db=m Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.12 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507050&form=6&db=m Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. causal interaction,unassigned 3,0 2.7.11.12 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355372&form=6&db=m Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha. therapeutic application,unassigned 4,0 2.7.11.12 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194177&form=6&db=m Expression and distribution of cyclic GMP-dependent protein kinase-1 isoforms in human penile erectile tissue. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18480246&form=6&db=m Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction. unassigned - 2.7.11.12 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23129789&form=6&db=m Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6297726&form=6&db=m Multiple forms of protein kinase from normal human brain and glioblastoma. ongoing research,unassigned 3,0 2.7.11.12 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12477052&form=6&db=m CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.12 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27564115&form=6&db=m Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior. Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.12 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6244301&form=6&db=m Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells. unassigned - 2.7.11.12 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12477052&form=6&db=m CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.12 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543319&form=6&db=m Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.7.11.12 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23404188&form=6&db=m Type II, but not type I, cGMP-dependent protein kinase reverses bFGF-induced proliferation and migration of U251 human glioma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27564115&form=6&db=m Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior. Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.12 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849123&form=6&db=m Type II cGMP?dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.12 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20930715&form=6&db=m Overexpression of Constitutively Active PKG-I Protects Female, But Not Male Mice From Diet-Induced Obesity. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.12 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18678579&form=6&db=m The cyclic GMP-dependent protein kinase II gene associates with gout disease identified by genome-wide analysis and case-control study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.12 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24882840&form=6&db=m Common variants of cGKII/PRKG2 are not associated with gout susceptibility. causal interaction,unassigned 4,0 2.7.11.12 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25475742&form=6&db=m Cyclic GMP-dependent protein kinase II is necessary for macrophage M1 polarization and phagocytosis via toll-like receptor 2. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.12 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25688884&form=6&db=m Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.12 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30123371&form=6&db=m Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout. unassigned - 2.7.11.12 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33194820&form=6&db=m "It Takes Two to Tango": Role of Neglected Macrophage Manipulators Coronin 1 and Protein Kinase G in Mycobacterial Pathogenesis. causal interaction,unassigned 4,0 2.7.11.12 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060898&form=6&db=m Left Ventricular Radial Function Associated With Genetic Variation in the cGMP-Dependent Protein Kinase. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.12 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26670943&form=6&db=m Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials. therapeutic application,unassigned 4,0 2.7.11.12 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848832&form=6&db=m Targeting Protein Kinase G to Treat Cardiac Proteotoxicity. therapeutic application,unassigned 1,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18040025&form=6&db=m Phosphodiesterase type 5: expanding roles in cardiovascular regulation. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22806632&form=6&db=m Low myocardial protein kinase g activity in heart failure with preserved ejection fraction. diagnostic usage,therapeutic application,unassigned 3,1,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684677&form=6&db=m A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. causal interaction,unassigned 1,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24255056&form=6&db=m Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25747598&form=6&db=m The Emperor's New Clothes: PDE5 and the Heart. therapeutic application,unassigned 1,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26477830&form=6&db=m Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-I? Substrate. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342776&form=6&db=m Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G I? Oxidation. therapeutic application,unassigned 2,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31464774&form=6&db=m cGMP Signaling and Modulation in Heart Failure. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848832&form=6&db=m Targeting Protein Kinase G to Treat Cardiac Proteotoxicity. therapeutic application,unassigned 1,0 2.7.11.12 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34328815&form=6&db=m Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction. therapeutic application,unassigned 2,0 2.7.11.12 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26203935&form=6&db=m Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations. unassigned - 2.7.11.12 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12775716&form=6&db=m cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.12 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19154345&form=6&db=m cGMP-dependent protein kinase II and aldosterone secretion. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.12 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32270922&form=6&db=m Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. unassigned - 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8821527&form=6&db=m Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211478&form=6&db=m The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin. therapeutic application,unassigned 3,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10658633&form=6&db=m Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord. unassigned - 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762667&form=6&db=m Activation of cGMP-dependent protein kinase Ialpha is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia. therapeutic application,unassigned 2,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384231&form=6&db=m Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. unassigned - 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809704&form=6&db=m Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12927197&form=6&db=m Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973199&form=6&db=m Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16120663&form=6&db=m cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression. causal interaction,unassigned 3,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17021029&form=6&db=m Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increased responsiveness to cAMP and cGMP. causal interaction,unassigned 2,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353555&form=6&db=m Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice. therapeutic application,unassigned 3,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896457&form=6&db=m Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20702721&form=6&db=m Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons. ongoing research,unassigned 1,0 2.7.11.12 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32773598&form=6&db=m Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464444&form=6&db=m Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia. unassigned - 2.7.11.12 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25863494&form=6&db=m Hyperglycemia down-regulates cGMP-dependent protein kinase I expression in first trimester cytotrophoblast cells. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.12 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31319371&form=6&db=m Cinaciguat in combination with insulin induces a favorable effect on implant osseointegration in type 2 diabetic rats. therapeutic application,unassigned 1,0 2.7.11.12 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32526339&form=6&db=m Lei-gong-gen formula granule attenuates hyperlipidemia in rats via cGMP-PKG signaling pathway. therapeutic application,unassigned 1,0 2.7.11.12 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715401&form=6&db=m Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.12 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21436345&form=6&db=m SNO-ing at the Nociceptive Synapse? causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427743&form=6&db=m Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.12 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32773598&form=6&db=m Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2530000&form=6&db=m Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization? causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855709&form=6&db=m Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction. therapeutic application,unassigned 1,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14512447&form=6&db=m Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle. causal interaction,unassigned 2,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14645134&form=6&db=m Regulation of gene expression by cyclic GMP. unassigned - 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14742673&form=6&db=m Nitric oxide regulates c-fos expression in nucleus tractus solitarii induced by baroreceptor activation via cGMP-dependent protein kinase and cAMP response element-binding protein phosphorylation. unassigned - 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507050&form=6&db=m Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. causal interaction,unassigned 3,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632465&form=6&db=m Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. causal interaction,unassigned 3,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448676&form=6&db=m High blood pressure arising from a defect in vascular function. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22245782&form=6&db=m Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. unassigned - 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22748498&form=6&db=m Endothelial dysfunction and systemic hypertension by selective cGMP-dependent protein kinase I inhibition using novel cell-penetrating peptide delivered in vivo. therapeutic application,unassigned 3,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23402556&form=6&db=m A Role of Intestine in Hypertension: Mechanism of Suppression of Intestinal Na-H Exchanger Isoform-3 in Spontaneously Hypertensive Rats. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684677&form=6&db=m A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. causal interaction,unassigned 1,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446801&form=6&db=m Genetic susceptibility to salt-sensitive hypertension in a Han Chinese population: a validation study of candidate genes. causal interaction,unassigned 4,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30871887&form=6&db=m The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln). causal interaction,unassigned 3,0 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32591971&form=6&db=m Genetically, Dietary Sodium Intake Is Causally Associated with Salt-Sensitive Hypertension Risk in a Community-Based Cohort Study: a Mendelian Randomization Approach. unassigned - 2.7.11.12 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33807627&form=6&db=m Rare Causes of Arterial Hypertension and Thoracic Aortic Aneurysms-A Case-Based Review. causal interaction,unassigned 1,0 2.7.11.12 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22632818&form=6&db=m Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923458&form=6&db=m Protein kinase G dysfunction is an important factor in induced pulmonary hypertension in mice. causal interaction,unassigned 4,0 2.7.11.12 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24452741&form=6&db=m Identification of nitrated tyrosine residues of protein kinase G-I? by mass spectrometry. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.12 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2530000&form=6&db=m Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization? causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2530000&form=6&db=m Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization? causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2530000&form=6&db=m Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization? causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590592&form=6&db=m The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase. ongoing research,unassigned 2,0 2.7.11.12 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25910559&form=6&db=m Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.12 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20463352&form=6&db=m Testosterone-induced modulation of nitric oxide-cGMP signaling pathway and androgenesis in the rat Leydig cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.12 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=196667&form=6&db=m Cyclic GMP-dependent and cyclic AMP-dependent protein kinases, protein kinase modulators and phosphodiesterases in arteries and veins of dogs. Distribution and effects of arteriovenous fistula and arterial occlusion. unassigned - 2.7.11.12 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684565&form=6&db=m Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=170098&form=6&db=m Protein kinase of bacteriophage T7. 1. Purification. therapeutic application,unassigned 1,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1101258&form=6&db=m In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase. unassigned - 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9020133&form=6&db=m cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12176727&form=6&db=m Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs. therapeutic application,unassigned 1,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12775716&form=6&db=m cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472248&form=6&db=m Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427012&form=6&db=m Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28874661&form=6&db=m A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission. therapeutic application,unassigned 2,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29617357&form=6&db=m Cyclic Guanosine Monophosphate (cGMP)-Dependent Protein Kinase II Blocks Epidermal Growth Factor (EGF)/Epidermal Growth Factor Receptor (EGFR)-Induced Biological Effects on Osteosarcoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30052626&form=6&db=m HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model. ongoing research,unassigned 2,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33194820&form=6&db=m "It Takes Two to Tango": Role of Neglected Macrophage Manipulators Coronin 1 and Protein Kinase G in Mycobacterial Pathogenesis. causal interaction,unassigned 4,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33938130&form=6&db=m Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity. therapeutic application,unassigned 1,0 2.7.11.12 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34092182&form=6&db=m M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival. therapeutic application,unassigned 1,0 2.7.11.12 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30195474&form=6&db=m cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation. ongoing research,unassigned 1,0 2.7.11.12 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27604828&form=6&db=m Further defining the critical genes for the 4q21 microdeletion disorder. causal interaction,unassigned 3,0 2.7.11.12 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423931&form=6&db=m cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.12 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28412213&form=6&db=m Acute Mast Cell Leukemia Associated with t(4;5)(q21;q33). unassigned - 2.7.11.12 Leukemia, Mast-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28412213&form=6&db=m Acute Mast Cell Leukemia Associated with t(4;5)(q21;q33). unassigned - 2.7.11.12 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390466&form=6&db=m Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.12 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28000100&form=6&db=m Marked response to imatinib mesylate in a patient with platelet-derived growth factor receptor beta-associated acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1 2.7.11.12 Loeys-Dietz Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29510914&form=6&db=m Testing patterns for genetically triggered aortic and arterial aneurysms and dissections at an academic center. diagnostic usage,unassigned 2,0 2.7.11.12 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11689177&form=6&db=m Inhibition of lordosis behavior by intrahypothalamic infusion of a protein kinase G antagonist. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.12 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14733891&form=6&db=m The nitric oxide pathway participates in estrous behavior induced by progesterone and some of its ring A-reduced metabolites. therapeutic application,unassigned 2,0 2.7.11.12 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319353&form=6&db=m Regulation of lordosis by cyclic 3',5'-guanosine monophosphate, progesterone, and its 5alpha-reduced metabolites involves mitogen-activated protein kinase. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.12 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22019256&form=6&db=m The nitric oxide pathway participates in lordosis behavior induced by central administration of leptin. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.12 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18650641&form=6&db=m Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.12 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=191831&form=6&db=m Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=193571&form=6&db=m Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line. ongoing research,unassigned 4,0 2.7.11.12 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22192662&form=6&db=m Cardiac uses of phosphodiesterase-5 inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23527712&form=6&db=m No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling. therapeutic application,unassigned 1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18532880&form=6&db=m Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase. unassigned - 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19915077&form=6&db=m The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. unassigned - 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675297&form=6&db=m Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. therapeutic application,unassigned 1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24594931&form=6&db=m Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites. causal interaction,unassigned 2,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25646845&form=6&db=m Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26149123&form=6&db=m Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion. therapeutic application,unassigned 1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29251493&form=6&db=m cGMP Binding Domain D Mediates a Unique Activation Mechanism in Plasmodium falciparum PKG. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31239348&form=6&db=m Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. causal interaction,unassigned 1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32317283&form=6&db=m Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32561554&form=6&db=m Keep a lid on it: A troika in kinase allostery. causal interaction,unassigned 1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33391223&form=6&db=m Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762339&form=6&db=m Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG. causal interaction,unassigned 1,0 2.7.11.12 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115498&form=6&db=m Dynamical Basis of Allosteric Activation for the Plasmodium falciparum Protein Kinase G. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.12 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10642443&form=6&db=m Effect of restricted food intake on production, catabolism, and effects of IGF-I and cyclic nucleotides in cultured ovarian tissue of domestic nutria (Myocastor coypus). therapeutic application,unassigned 1,0 2.7.11.12 Marfan Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33976159&form=6&db=m Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO. therapeutic application,unassigned 3,0 2.7.11.12 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26971999&form=6&db=m Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34265328&form=6&db=m Activation of cGMP-Dependent Protein Kinase Restricts Melanoma Growth and Invasion by Interfering with the EGF/EGFR Pathway. unassigned - 2.7.11.12 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23103773&form=6&db=m Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.12 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507050&form=6&db=m Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. causal interaction,unassigned 3,0 2.7.11.12 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27207514&form=6&db=m Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase. causal interaction,unassigned 3,0 2.7.11.12 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770022&form=6&db=m Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Myeloproliferative Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390466&form=6&db=m Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.12 Myeloproliferative Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262053&form=6&db=m Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29401205&form=6&db=m Protein Kinases Type II (PKG II) Combined with L-Arginine Significantly Ameliorated Xenograft Tumor Development: Is L-Arginine a Potential Alternative in PKG II Activation? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.7.11.12 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434677&form=6&db=m The constitutively active PKG II mutant effectively inhibits gastric cancer development causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=232964&form=6&db=m Basal, cAMP- and cGMP-dependent protein kinases in human brain tumors. causal interaction,unassigned 3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319722&form=6&db=m Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytes. ongoing research,unassigned 3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3697380&form=6&db=m Characterization of protein tyrosine kinase activity in murine Leydig tumor cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8817470&form=6&db=m Atrial natriuretic peptide inhibits the phosphoinositide hydrolysis in murine Leydig tumor cells. therapeutic application,unassigned 3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726636&form=6&db=m Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10615072&form=6&db=m Tumor necrosis factor-alpha-induced activating protein-1 activity is modulated by nitric oxide-mediated protein kinase G activation. causal interaction,unassigned 1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11358813&form=6&db=m Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. causal interaction,unassigned 1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11602670&form=6&db=m Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12477052&form=6&db=m CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15173009&form=6&db=m Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15448151&form=6&db=m Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation. unassigned - 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475462&form=6&db=m Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells. unassigned - 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15750623&form=6&db=m Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice. diagnostic usage,unassigned 1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16234412&form=6&db=m A Xanthine-Based Epithelium-Dependent Airway Relaxant KMUP-3 (7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) Increases Respiratory Performance and Protects against Tumor Necrosis Factor-{alpha}-Induced Tracheal Contraction, Involving Nitric Oxide Release and Expression of cGMP and Protein Kinase G. unassigned - 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256267&form=6&db=m An anti-tumor role for cGMP-dependent protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16432163&form=6&db=m The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization. therapeutic application,unassigned 3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16754782&form=6&db=m Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G. ongoing research,unassigned 1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18163459&form=6&db=m Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168131&form=6&db=m Cyclic GMP specifically suppresses Type-Ialpha cGMP-dependent protein kinase expression by ubiquitination. ongoing research,unassigned 2,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543319&form=6&db=m Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21777390&form=6&db=m Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22012247&form=6&db=m Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22095901&form=6&db=m Induction of apoptosis by type I? protein kinase G in the human breast cancer cell lines MCF-7 and MDA-MB-468. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22556201&form=6&db=m A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and ?-catenin transcriptional activity. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22580283&form=6&db=m cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162660&form=6&db=m Endogenous cGMP-dependent protein kinase reverses EGF-induced MAPK/ERK signal transduction through phosphorylation of VASP at Ser239. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23804703&form=6&db=m Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/?-Catenin Signaling. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24648957&form=6&db=m Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25751011&form=6&db=m Mini Review: Pathophysiology of Erectile Dysfunction. therapeutic application,unassigned 1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25950641&form=6&db=m Pathophysiology of erectile dysfunction. therapeutic application,unassigned 1,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26105003&form=6&db=m Anti-tumor properties of the cGMP/protein kinase G inhibitor DT3 in pancreatic adenocarcinoma. causal interaction,unassigned 3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26137146&form=6&db=m Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26160748&form=6&db=m Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury. diagnostic usage,ongoing research,unassigned 4,2,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808213&form=6&db=m The interaction between the Wnt/?-catenin signaling cascade and PKG activation in cancer. causal interaction,unassigned 3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849123&form=6&db=m Type II cGMP?dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050202&form=6&db=m Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking ?-catenin and MAPK signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150923&form=6&db=m PKG II effectively reversed EGF-induced protein expression alterations in human gastric cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29401205&form=6&db=m Protein Kinases Type II (PKG II) Combined with L-Arginine Significantly Ameliorated Xenograft Tumor Development: Is L-Arginine a Potential Alternative in PKG II Activation? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434677&form=6&db=m The constitutively active PKG II mutant effectively inhibits gastric cancer development causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773997&form=6&db=m Bioactive compounds in plant materials for the prevention of diabetesand obesity. unassigned - 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31196969&form=6&db=m Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability. unassigned - 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350342&form=6&db=m Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/MEK and PI3K/Akt signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.12 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33926391&form=6&db=m High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.12 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16120663&form=6&db=m cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression. causal interaction,unassigned 3,0 2.7.11.12 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716216&form=6&db=m cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.12 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23819209&form=6&db=m [Involvement of hippocampal NO/PKG signaling pathway in the accumulative analgesic effect of electroacupuncture stimulation of "Zusanli" (ST 36)-"Yanglingquan"(GB 34) in chronic neuropathic pain rats]. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.12 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24450940&form=6&db=m Oxidant-Induced Activation of cGMP-Dependent Protein Kinase I? Mediates Neuropathic Pain After Peripheral Nerve Injury. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27978504&form=6&db=m Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.12 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32773598&form=6&db=m Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6256479&form=6&db=m Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells. unassigned - 2.7.11.12 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10653609&form=6&db=m Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.12 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22503686&form=6&db=m cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells. unassigned - 2.7.11.12 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15917860&form=6&db=m Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 2.7.11.12 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20930715&form=6&db=m Overexpression of Constitutively Active PKG-I Protects Female, But Not Male Mice From Diet-Induced Obesity. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.12 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30593979&form=6&db=m PKG1? oxidation negatively regulates food seeking behaviour and reward. causal interaction,unassigned 4,0 2.7.11.12 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29617357&form=6&db=m Cyclic Guanosine Monophosphate (cGMP)-Dependent Protein Kinase II Blocks Epidermal Growth Factor (EGF)/Epidermal Growth Factor Receptor (EGFR)-Induced Biological Effects on Osteosarcoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.12 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20371672&form=6&db=m Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.7.11.12 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350342&form=6&db=m Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/MEK and PI3K/Akt signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.12 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32096871&form=6&db=m Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer. causal interaction,diagnostic usage,unassigned 2,4,0 2.7.11.12 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550449&form=6&db=m The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of C. elegans. unassigned - 2.7.11.12 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770022&form=6&db=m Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24450940&form=6&db=m Oxidant-Induced Activation of cGMP-Dependent Protein Kinase I? Mediates Neuropathic Pain After Peripheral Nerve Injury. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715401&form=6&db=m Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.7.11.12 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32773598&form=6&db=m Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.12 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2879892&form=6&db=m Phosphorylation of tyrosine hydroxylase by cyclic GMP-dependent protein kinase. diagnostic usage,unassigned 1,0 2.7.11.12 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192298&form=6&db=m Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.12 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18650641&form=6&db=m Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.12 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33093639&form=6&db=m Abnormal cGMP-dependent protein kinase I-mediated decidualization in preeclampsia. unassigned - 2.7.11.12 Priapism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23844149&form=6&db=m Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 2.7.11.12 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507050&form=6&db=m Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. causal interaction,unassigned 3,0 2.7.11.12 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684677&form=6&db=m A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. causal interaction,unassigned 1,0 2.7.11.12 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19286961&form=6&db=m ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19674116&form=6&db=m Molecular aspects of ischaemic postconditioning. unassigned - 2.7.11.12 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292628&form=6&db=m Overexpression of protein kinase G using adenovirus inhibits cyclin E transcription and mesangial cell cycle. therapeutic application,unassigned 1,0 2.7.11.12 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19654912&form=6&db=m Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. therapeutic application,unassigned 2,0 2.7.11.12 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6283546&form=6&db=m Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase. ongoing research,unassigned 1,0 2.7.11.12 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=52872&form=6&db=m Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.12 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6281757&form=6&db=m Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.12 Scoliosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32558266&form=6&db=m Upregulation of cGMP-dependent Protein Kinase (PRKG1) in the Development of Adolescent Idiopathic Scoliosis. unassigned - 2.7.11.12 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587280&form=6&db=m Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.12 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29798846&form=6&db=m Contribution of a natural polymorphism in protein kinase G modulates electroconvulsive seizure recovery in Drosophila melanogaster. ongoing research,unassigned 2,0 2.7.11.12 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23716652&form=6&db=m Protein kinase G oxidation is a major cause of injury during sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.12 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887778&form=6&db=m [Effect of protein kinase on endothelial cytoskeleton induced by septic shock] ongoing research,unassigned 4,0 2.7.11.12 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22308351&form=6&db=m foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila. therapeutic application,unassigned 1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472248&form=6&db=m Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22012247&form=6&db=m Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940826&form=6&db=m Type II cGMP-dependent protein kinase inhibits ERK/JNK-mediated activation of transcription factors in gastric cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23613900&form=6&db=m PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24273605&form=6&db=m Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24534906&form=6&db=m Type II cGMP-dependent protein kinase inhibits ligand?induced activation of EGFR in gastric cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24549567&form=6&db=m Type II cGMP?dependent protein kinase inhibits RhoA activation in gastric cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24648957&form=6&db=m Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26171055&form=6&db=m Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26171059&form=6&db=m Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26676300&form=6&db=m Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27147579&form=6&db=m PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells. unassigned - 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150923&form=6&db=m PKG II effectively reversed EGF-induced protein expression alterations in human gastric cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434677&form=6&db=m The constitutively active PKG II mutant effectively inhibits gastric cancer development causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29935031&form=6&db=m PKG II inhibits PDGF-BB triggered biological activities by phosphorylating PDGFR? in gastric cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.12 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31395339&form=6&db=m Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.12 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10851246&form=6&db=m Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I. therapeutic application,unassigned 1,0 2.7.11.12 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684565&form=6&db=m Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.12 Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269222&form=6&db=m Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.12 Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561748&form=6&db=m Killing me softly - suicidal erythrocyte death. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Thalassemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23801921&form=6&db=m Physiology and pathophysiology of eryptosis. causal interaction,unassigned 2,0 2.7.11.12 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21224207&form=6&db=m Prediction of the post-translational modification sites on dengue virus E protein and deciphering their role in pathogenesis. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.12 Thrombocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23788765&form=6&db=m Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.12 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24531539&form=6&db=m The nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activation. causal interaction,unassigned 1,0 2.7.11.12 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11796334&form=6&db=m Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11897122&form=6&db=m Molecular characterization of a coccidian parasite cGMP dependent protein kinase. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.12 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325279&form=6&db=m Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496007&form=6&db=m Serine/threonine protein kinases PknF and PknG of Mycobacterium tuberculosis: characterization and localization. unassigned - 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616581&form=6&db=m Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19019160&form=6&db=m Regulation of glutamate metabolism by protein kinases in mycobacteria. causal interaction,unassigned 2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638631&form=6&db=m Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21904430&form=6&db=m Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22973091&form=6&db=m Exploring prospects of novel drugs for tuberculosis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25839674&form=6&db=m Expression and purification of the natively disordered and redox sensitive metal binding regions of Mycobacterium tuberculosis protein kinase G. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25884716&form=6&db=m A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development. causal interaction,unassigned 2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27632081&form=6&db=m Chemical shift assignment of the intrinsically disordered N-terminus and the rubredoxin domain in the folded metal bound and unfolded oxidized state of mycobacterial protein kinase G. causal interaction,unassigned 2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27810897&form=6&db=m Oxidative Unfolding of the Rubredoxin Domain and the Natively Disordered N-terminal Region Regulate the Catalytic Activity of Mycobacterium tuberculosis Protein Kinase G. ongoing research,unassigned 2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28237032&form=6&db=m Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages. ongoing research,unassigned 3,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249794&form=6&db=m Identification of mycobacterial GarA as a substrate of protein kinase G from M. tuberculosis using a KESTREL-based proteome wide approach. therapeutic application,unassigned 1,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28545104&form=6&db=m PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. ongoing research,unassigned 2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28821621&form=6&db=m Protein Kinase G confers survival advantage to Mycobacterium tuberculosis during latency like conditions. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30050511&form=6&db=m Identification of Novel Mycobacterial Inhibitors Against Mycobacterial Protein Kinase G. unassigned - 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30065086&form=6&db=m An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria. unassigned - 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31285226&form=6&db=m NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G. ongoing research,unassigned 2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31698813&form=6&db=m Predictive Binding Affinity of Plant-Derived Natural Products Towards the Protein Kinase G Enzyme of Mycobacterium tuberculosis (MtPknG). diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32060126&form=6&db=m Correction: Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33938130&form=6&db=m Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity. therapeutic application,unassigned 1,0 2.7.11.12 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34092182&form=6&db=m M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival. therapeutic application,unassigned 1,0 2.7.11.12 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507050&form=6&db=m Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. causal interaction,unassigned 3,0 2.7.11.12 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632465&form=6&db=m Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. causal interaction,unassigned 3,0 2.7.11.12 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23139241&form=6&db=m Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1835499&form=6&db=m Pertussis toxin-sensitive and insensitive guanine nucleotide binding proteins (G-proteins) are not phosphorylated by cyclic GMP-dependent protein kinase. unassigned - 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846548&form=6&db=m Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7721818&form=6&db=m Cyclic GMP-dependent protein kinase blocks pertussis toxin-sensitive hormone receptor signaling pathways in Chinese hamster ovary cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626445&form=6&db=m Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor. therapeutic application,unassigned 1,0 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359874&form=6&db=m Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways. therapeutic application,unassigned 4,0 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815090&form=6&db=m Atrial natriuretic peptide clearance receptor participates in modulating endothelial permeability. therapeutic application,unassigned 1,0 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12690035&form=6&db=m Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium. unassigned - 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577183&form=6&db=m Ghrelin signalling in guinea-pig femoral artery smooth muscle cells. therapeutic application,unassigned 1,0 2.7.11.12 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31638216&form=6&db=m C?type natriuretic peptide prevents angiotensin II?induced atrial connexin 40 and 43 dysregulation by activating AMP?activated kinase signaling. ongoing research,unassigned 3,0