2.7.11.11	Acidosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=80985&form=6&db=m	Effect of acidosis on heart cAMP-dependent protein kinase.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,4,2	
2.7.11.11	Acidosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6167223&form=6&db=m	Effect of pH on lipolysis, cAMP and cAMP-dependent protein kinase activity in isolated rat fat cells.	ongoing research,unassigned	2,0	
2.7.11.11	Acidosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6787936&form=6&db=m	Effect of metabolic acidosis on renal response to parathyroid hormone in phosphorus-deprived rats.	unassigned	-	
2.7.11.11	Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178799&form=6&db=m	Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells.	therapeutic application,unassigned	1,0	
2.7.11.11	ACTH-Secreting Pituitary Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26701869&form=6&db=m	Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.	causal interaction,diagnostic usage,unassigned	2,1,0	
2.7.11.11	ACTH-Secreting Pituitary Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29735160&form=6&db=m	Genomic insights into Cushing syndrome.	causal interaction,unassigned	1,0	
2.7.11.11	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1457341&form=6&db=m	Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus.	causal interaction,diagnostic usage,unassigned	1,2,0	
2.7.11.11	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6262879&form=6&db=m	Parallel activation of cyclic AMP phosphodiesterase and cyclic AMP-dependent protein kinase in two human gut adenocarcinoma cells (HT 29 and HRT 18) in culture, by vasoactive intestinal peptide (VIP) and other effectors activating the cyclic AMP system.	ongoing research,unassigned	1,0	
2.7.11.11	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9211870&form=6&db=m	Protein kinase A activation of the surfactant protein B gene is mediated by phosphorylation of thyroid transcription factor 1.	therapeutic application,unassigned	1,0	
2.7.11.11	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861501&form=6&db=m	CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24003140&form=6&db=m	Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24880079&form=6&db=m	XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.	therapeutic application,unassigned	3,0	
2.7.11.11	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27932759&form=6&db=m	[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].	diagnostic usage,ongoing research,unassigned	2,3,0	
2.7.11.11	Adenocarcinoma, Follicular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18480379&form=6&db=m	Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6327022&form=6&db=m	Functional changes in the regulatory subunit of the type II cyclic adenosine 3':5'-monophosphate-dependent protein kinase isozyme during normal and neoplastic lung development.	ongoing research,unassigned	2,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545137&form=6&db=m	Human GHRH reduces voltage-gated K+ currents via a non-cAMP-dependent but PKC-mediated pathway in human GH adenoma cells.	unassigned	-	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12641630&form=6&db=m	GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24.	causal interaction,unassigned	1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111774&form=6&db=m	How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?	causal interaction,unassigned	3,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25057884&form=6&db=m	Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,3,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25069672&form=6&db=m	Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,2,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750087&form=6&db=m	PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia - a single-center study of 60 cases.	causal interaction,unassigned	4,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871963&form=6&db=m	Protein kinase A defects and cortisol-producing adrenal tumors.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,3,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26038203&form=6&db=m	The genetics of adrenocortical tumors.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26139209&form=6&db=m	cAMP signaling in cortisol-producing adrenal adenoma.	causal interaction,diagnostic usage,unassigned	4,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26701869&form=6&db=m	Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.	causal interaction,diagnostic usage,unassigned	2,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26739091&form=6&db=m	ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.	unassigned	-	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743443&form=6&db=m	GNAS mutations in adrenal aldosterone-producing adenomas [Rapid Communication].	causal interaction,unassigned	3,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26965378&form=6&db=m	A genetic and molecular update on adrenocortical causes of Cushing syndrome.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27015136&form=6&db=m	Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss.	causal interaction,diagnostic usage,therapeutic application,unassigned	2,3,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270477&form=6&db=m	PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,3,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27296931&form=6&db=m	Clinical characteristics of PRKACA mutations in Chinese patients with adrenal lesions: a single-centre study.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27454103&form=6&db=m	Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016).	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871112&form=6&db=m	PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.	causal interaction,diagnostic usage,unassigned	4,3,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405879&form=6&db=m	Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.	diagnostic usage,ongoing research,unassigned	3,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28834963&form=6&db=m	Lipofuscin Accumulation in Cortisol-Producing Adenomas With and Without PRKACA Mutations.	ongoing research,unassigned	1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28973103&form=6&db=m	Genetic Causes of Functional Adrenocortical Adenomas.	unassigned	-	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632813&form=6&db=m	Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.	unassigned	-	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29735160&form=6&db=m	Genomic insights into Cushing syndrome.	causal interaction,unassigned	1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207362&form=6&db=m	Genomics of benign adrenocortical tumors.	causal interaction,unassigned	1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31276155&form=6&db=m	Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.	causal interaction,diagnostic usage,unassigned	3,3,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32783015&form=6&db=m	Molecular Basis of Primary Aldosteronism and Adrenal Cushing Syndrome.	causal interaction,unassigned	4,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32875319&form=6&db=m	RNA-Sequencing and Somatic Mutation Status of Adrenocortical Tumors: Novel Pathogenetic Insights.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,3,1,0	
2.7.11.11	Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520814&form=6&db=m	Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.	causal interaction,unassigned	3,0	
2.7.11.11	Adenoma, Liver Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597357&form=6&db=m	Update on the pathology of liver neoplasms.	unassigned	-	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24855271&form=6&db=m	Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.	unassigned	-	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25057884&form=6&db=m	Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,3,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105543&form=6&db=m	Protein kinase A alterations in adrenocortical tumors.	causal interaction,unassigned	2,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225481&form=6&db=m	Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.	causal interaction,unassigned	1,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26042218&form=6&db=m	PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.	causal interaction,diagnostic usage,ongoing research,unassigned	4,3,2,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26139209&form=6&db=m	cAMP signaling in cortisol-producing adrenal adenoma.	causal interaction,diagnostic usage,unassigned	4,1,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26684645&form=6&db=m	5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.	causal interaction,unassigned	1,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26701869&form=6&db=m	Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.	causal interaction,diagnostic usage,unassigned	2,1,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165862&form=6&db=m	Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.	causal interaction,diagnostic usage,therapeutic application,unassigned	2,1,1,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27389594&form=6&db=m	Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.	causal interaction,unassigned	4,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27813054&form=6&db=m	Mechanisms of Aberrant PKA Activation by C? Subunit Mutations.	causal interaction,diagnostic usage,unassigned	3,3,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28369983&form=6&db=m	Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.	causal interaction,diagnostic usage,unassigned	2,3,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30615103&form=6&db=m	Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.	causal interaction,unassigned	1,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31489371&form=6&db=m	Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.	diagnostic usage,unassigned	3,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33608270&form=6&db=m	PKA C? subunit mutation triggers caspase-dependent RII? subunit degradation via Ser114 phosphorylation.	causal interaction,unassigned	3,0	
2.7.11.11	Adrenocortical Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34224748&form=6&db=m	Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?	unassigned	-	
2.7.11.11	Adrenocortical Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=195724&form=6&db=m	Partial purification and characterization of the defective cyclic adenosine 3':5'-monophosphate binding protein kinase from adrenocortical carcinoma.	ongoing research,unassigned	1,0	
2.7.11.11	Adrenocortical Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8853907&form=6&db=m	Cisplatin resistance and regulation of DNA repair in cAMP-dependent protein kinase mutants.	therapeutic application,unassigned	1,0	
2.7.11.11	Adrenocortical Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9419412&form=6&db=m	Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.	unassigned	-	
2.7.11.11	Adrenocortical Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858882&form=6&db=m	Cisplatin sensitivity in cAMP-dependent protein kinase mutants of Saccharomyces cerevisiae.	therapeutic application,unassigned	1,0	
2.7.11.11	Adrenocortical Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26739091&form=6&db=m	ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.	unassigned	-	
2.7.11.11	Adrenocortical Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27296931&form=6&db=m	Clinical characteristics of PRKACA mutations in Chinese patients with adrenal lesions: a single-centre study.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,1,0	
2.7.11.11	Adrenocortical Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29735160&form=6&db=m	Genomic insights into Cushing syndrome.	causal interaction,unassigned	1,0	
2.7.11.11	Albinism, Oculocutaneous	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25396269&form=6&db=m	A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.	diagnostic usage,ongoing research,unassigned	1,1,0	
2.7.11.11	Alcohol Withdrawal Seizures	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27716957&form=6&db=m	Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.	causal interaction,unassigned	4,0	
2.7.11.11	Alkalosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6167223&form=6&db=m	Effect of pH on lipolysis, cAMP and cAMP-dependent protein kinase activity in isolated rat fat cells.	ongoing research,unassigned	2,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1511290&form=6&db=m	Regional localization of the regulatory subunit (RII beta) of the type II cAMP-dependent protein kinase in human brain.	ongoing research,unassigned	4,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527090&form=6&db=m	Phosphorylation of tau protein by purified p34cdc28 and a related protein kinase from neurofilaments.	causal interaction,unassigned	3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8166686&form=6&db=m	Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's disease.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8419532&form=6&db=m	Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.	causal interaction,unassigned	3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8748927&form=6&db=m	cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer disease.	ongoing research,unassigned	4,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930361&form=6&db=m	Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9736660&form=6&db=m	A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.	ongoing research,unassigned	4,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082824&form=6&db=m	A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.	causal interaction,unassigned	3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10460255&form=6&db=m	cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.	causal interaction,ongoing research,unassigned	2,2,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14690518&form=6&db=m	Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.	ongoing research,unassigned	2,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17241267&form=6&db=m	Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.	ongoing research,unassigned	3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908236&form=6&db=m	Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain.	causal interaction,unassigned	3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21367856&form=6&db=m	Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer's disease.	causal interaction,unassigned	3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23218601&form=6&db=m	Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.	causal interaction,unassigned	1,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25237037&form=6&db=m	Insulin resistance in Alzheimer's disease.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29710715&form=6&db=m	Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions.	causal interaction,unassigned	4,0	
2.7.11.11	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32715279&form=6&db=m	Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Anthrax	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307216&form=6&db=m	Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A (PKA) and exchange protein activated by cAMP (Epac) pathways.	unassigned	-	
2.7.11.11	Arrhythmias, Cardiac	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884369&form=6&db=m	Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes.	causal interaction,unassigned	1,0	
2.7.11.11	Asthma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23509367&form=6&db=m	Calcitonin Gene-Related Peptide and Cyclic Adenosine 5'-Monophosphate/Protein Kinase A Pathway Promote IL-9 Production in Th9 Differentiation Process.	unassigned	-	
2.7.11.11	Asthma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28442571&form=6&db=m	?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359863&form=6&db=m	Thrombin produces phosphorylation of cytosolic phospholipase A2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell line 1321N1.	ongoing research,unassigned	4,0	
2.7.11.11	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15952716&form=6&db=m	Proteomic studies on low- and high-grade human brain astrocytomas.	causal interaction,unassigned	3,0	
2.7.11.11	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16126335&form=6&db=m	An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,1,0	
2.7.11.11	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16891468&form=6&db=m	Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,3,0	
2.7.11.11	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24620973&form=6&db=m	Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,4,0	
2.7.11.11	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27704563&form=6&db=m	Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.	ongoing research,unassigned	1,0	
2.7.11.11	Ataxia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17102619&form=6&db=m	Microcephalin: a causal link between impaired damage response signalling and microcephaly.	causal interaction,unassigned	3,0	
2.7.11.11	Ataxia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18182058&form=6&db=m	Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques.	unassigned	-	
2.7.11.11	Ataxia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21192968&form=6&db=m	Sustained antagonism of acute ethanol-induced ataxia following microinfusion of cyclic AMP and cpt-cAMP in the mouse cerebellum.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507302&form=6&db=m	Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405908&form=6&db=m	Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17564965&form=6&db=m	Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling.	causal interaction,unassigned	1,0	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18506893&form=6&db=m	Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.	unassigned	-	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19746225&form=6&db=m	Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA.	causal interaction,unassigned	1,0	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23849791&form=6&db=m	Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells.	unassigned	-	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24672010&form=6&db=m	ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage.	causal interaction,unassigned	4,0	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25540325&form=6&db=m	Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427511&form=6&db=m	Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability.	unassigned	-	
2.7.11.11	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32810137&form=6&db=m	ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Atherosclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29146892&form=6&db=m	Intermedin Ameliorates Atherosclerosis by Increasing Cholesterol Efflux Through the cAMP-PKA Pathway in Macrophage RAW264.7 Cell Line.	ongoing research,unassigned	1,0	
2.7.11.11	Autoimmune Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33357183&form=6&db=m	Design and Synthesis of New JAK1 Inhibitors based on SulfonamideTriazine Conjugates.	causal interaction,diagnostic usage,unassigned	3,3,0	
2.7.11.11	Autoimmune Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34130529&form=6&db=m	Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,3,1,0	
2.7.11.11	Bacteremia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26112911&form=6&db=m	Complex host genetic susceptibility to Staphylococcus aureus infections.	causal interaction,therapeutic application,unassigned	1,3,0	
2.7.11.11	Biliary Tract Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31908303&form=6&db=m	Second-line therapies in advanced biliary tract cancers.	unassigned	-	
2.7.11.11	Blister	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33368671&form=6&db=m	The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.	unassigned	-	
2.7.11.11	Bone Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24978483&form=6&db=m	Activation of the cAMP-PKA signaling pathway in rat dorsal root ganglion and spinal cord contributes toward induction and maintenance of bone cancer pain.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Bone Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26989332&form=6&db=m	Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,4,0	
2.7.11.11	Bone Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31223142&form=6&db=m	Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury.	therapeutic application,unassigned	2,0	
2.7.11.11	Bone Resorption	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311571&form=6&db=m	The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,1,4,1	
2.7.11.11	Bone Resorption	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324163&form=6&db=m	Differential effects of the 3',5'-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin.	therapeutic application,unassigned	4,0	
2.7.11.11	Bone Resorption	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8225186&form=6&db=m	Role of dual signal transduction systems in the stimulation of bone resorption by parathyroid hormone-related peptide. The direct involvement of cAMP-dependent protein kinase.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Bone Resorption	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15741694&form=6&db=m	[Effects of calcitonin on osteoclast]	therapeutic application,unassigned	1,0	
2.7.11.11	Bone Resorption	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644480&form=6&db=m	cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Bradycardia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564147&form=6&db=m	5-HT(4) receptors in nucleus tractus solitarii attenuate cardiopulmonary reflex in anesthetized rats.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,1,3,0	
2.7.11.11	Brain Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31232219&form=6&db=m	Aminoglycoside drugs induce efficient read-through of CDKL5 nonsense mutations, slightly restoring its kinase activity.	causal interaction,unassigned	3,0	
2.7.11.11	Brain Injuries, Traumatic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23238576&form=6&db=m	Age-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injury.	therapeutic application,unassigned	2,0	
2.7.11.11	Brain Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579200&form=6&db=m	Inhibition of cyclic AMP-dependent protein kinase in the acute phase of focal cerebral ischemia in the rat.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,4,0	
2.7.11.11	Brain Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11403878&form=6&db=m	Alteration of second messengers during acute cerebral ischemia - adenylate cyclase, cyclic AMP-dependent protein kinase, and cyclic AMP response element binding protein.	therapeutic application,unassigned	1,0	
2.7.11.11	Brain Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11744000&form=6&db=m	A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat.	therapeutic application,unassigned	4,0	
2.7.11.11	Brain Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12150772&form=6&db=m	Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats.	ongoing research,unassigned	2,0	
2.7.11.11	Brain Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575811&form=6&db=m	Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Brain Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2369736&form=6&db=m	Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.	causal interaction,ongoing research,unassigned	2,4,0	
2.7.11.11	Brain Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33526470&form=6&db=m	Gain of HIF1 Activity and Loss of miRNA let-7d Promote Breast Cancer Metastasis to the Brain via the PDGF/PDGFR Axis.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,1,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830966&form=6&db=m	Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.	ongoing research,unassigned	3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6299590&form=6&db=m	Mitotic apparatus and nucleoli compartmentalization of 50,000-dalton type II regulatory subunit of cAMP-dependent protein kinase in estrogen receptor negative MDA-MB-231 human breast cancer cells.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6331652&form=6&db=m	Nucleolar accumulation of cyclic adenosine 3':5'-monophosphate receptor proteins during regression of MCF-7 human breast tumor.	ongoing research,unassigned	3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6596096&form=6&db=m	Characteristics of selective activation of cyclic AMP-dependent protein kinase isoenzymes by calcitonin and prostaglandin E2 in human breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	1,4,1,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7881104&form=6&db=m	Transcriptional regulation of multidrug resistance in breast cancer.	diagnostic usage,ongoing research,unassigned	4,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8562304&form=6&db=m	Regulation of multidrug resistance through the cAMP and EGF signalling pathways.	diagnostic usage,ongoing research,unassigned	4,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9493976&form=6&db=m	Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector.	ongoing research,unassigned	4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696392&form=6&db=m	Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446459&form=6&db=m	Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,3,3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10502413&form=6&db=m	The biphasic induction of p21 and p27 in breast cancer cells by modulators of cAMP is posttranscriptionally regulated and independent of the PKA pathway.	ongoing research,unassigned	4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10606728&form=6&db=m	Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells.	ongoing research,unassigned	4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11469804&form=6&db=m	Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11517301&form=6&db=m	The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers.	ongoing research,unassigned	3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12080384&form=6&db=m	Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,4	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970465&form=6&db=m	Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells.	ongoing research,unassigned	2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18409049&form=6&db=m	Differential regulation of ErbB2 expression by cAMP-dependent protein kinase in tamoxifen-resistant breast cancer cells.	causal interaction,ongoing research,unassigned	3,4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18499756&form=6&db=m	Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase.	unassigned	-	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18502714&form=6&db=m	Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation.	ongoing research,therapeutic application,unassigned	2,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20729911&form=6&db=m	The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21807936&form=6&db=m	PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.	causal interaction,diagnostic usage,ongoing research,unassigned	3,3,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324574&form=6&db=m	Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,1	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24694813&form=6&db=m	Quantitation of cellular phosphorylation dynamics by phosphoproteomics approaches.	therapeutic application,unassigned	2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24909179&form=6&db=m	PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225290&form=6&db=m	A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25362855&form=6&db=m	A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.	causal interaction,therapeutic application,unassigned	2,4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25670169&form=6&db=m	CLK2 is an oncogenic kinase and splicing regulator in breast cancer.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25706943&form=6&db=m	SRC drives growth of antiestrogen resistant breast cancer cell lines and is a marker for reduced benefit of tamoxifen treatment.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481935&form=6&db=m	The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27499891&form=6&db=m	Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,4	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27829216&form=6&db=m	ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.	therapeutic application,unassigned	4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27904695&form=6&db=m	Overexpression of AKIP1 predicts poor prognosis of patients with breast carcinoma and promotes cancer metastasis through Akt/GSK-3?/Snail pathway.	causal interaction,unassigned	1,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28174265&form=6&db=m	SGK3 sustains ER? signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28262781&form=6&db=m	WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29219195&form=6&db=m	Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer.	unassigned	-	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29289986&form=6&db=m	Phase I trial to evaluate the addition of alisertib to fulvestrant in women with endocrine-resistant, ER+ metastatic breast cancer.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30206213&form=6&db=m	Identification of protein kinase inhibitors to reprogram breast cancer cells.	causal interaction,therapeutic application,unassigned	1,3,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30424508&form=6&db=m	IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32058239&form=6&db=m	Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,4,4,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245732&form=6&db=m	MicroRNA-based regulation of Aurora A kinase in breast cancer.	ongoing research,unassigned	2,0	
2.7.11.11	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33543028&form=6&db=m	Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells.	causal interaction,unassigned	1,0	
2.7.11.11	Brucellosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12759440&form=6&db=m	Subversion and utilization of the host cell cyclic adenosine 5'-monophosphate/protein kinase A pathway by Brucella during macrophage infection.	causal interaction,unassigned	1,0	
2.7.11.11	camp-dependent protein kinase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1644803&form=6&db=m	Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes.	causal interaction,ongoing research,unassigned	2,3,0	
2.7.11.11	camp-dependent protein kinase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403274&form=6&db=m	High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.	causal interaction,diagnostic usage,unassigned	4,3,0	
2.7.11.11	camp-dependent protein kinase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11390516&form=6&db=m	Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	camp-dependent protein kinase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736129&form=6&db=m	cAMP and protein kinase A in endocrine (and other) tumors.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3568986&form=6&db=m	[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4027963&form=6&db=m	Effect of gastrin on gastric mucosal cyclic adenosine 3':5'-monophosphate-dependent protein kinase activity in rat stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine.	causal interaction,therapeutic application,unassigned	4,2,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6303567&form=6&db=m	Anticarcinogenic effect of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate on 7,12-dimethylbenz(a)anthracene mammary tumor induction in the rat and its relationship to cyclic adenosine 3':5'-monophosphate metabolism and protein kinase.	therapeutic application,unassigned	1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10577386&form=6&db=m	Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12119280&form=6&db=m	Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12424709&form=6&db=m	Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.	unassigned	-	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12666684&form=6&db=m	Clinical and molecular genetics of Carney complex.	causal interaction,unassigned	3,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240549&form=6&db=m	Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16126335&form=6&db=m	An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17613552&form=6&db=m	Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis.	causal interaction,unassigned	4,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18451138&form=6&db=m	Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.	causal interaction,unassigned	4,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18505904&form=6&db=m	Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.	diagnostic usage,therapeutic application,unassigned	1,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19651783&form=6&db=m	Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop.	unassigned	-	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20196102&form=6&db=m	Biology of Aurora A kinase: Implications in cancer manifestation and therapy.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21852354&form=6&db=m	Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22396649&form=6&db=m	Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533274&form=6&db=m	TPL2 kinase is a suppressor of lung carcinogenesis.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23661421&form=6&db=m	Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,2,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24222664&form=6&db=m	Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.	causal interaction,unassigned	1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24722282&form=6&db=m	Liver kinase B1 regulates the centrosome via PLK1.	causal interaction,unassigned	1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24815698&form=6&db=m	Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26042218&form=6&db=m	PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.	causal interaction,diagnostic usage,ongoing research,unassigned	4,3,2,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123587&form=6&db=m	Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine.	therapeutic application,unassigned	2,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26417066&form=6&db=m	The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression.	therapeutic application,unassigned	1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26684827&form=6&db=m	Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis.	ongoing research,unassigned	3,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446442&form=6&db=m	HPV16 E6 upregulates Aurora A expression.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28369983&form=6&db=m	Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.	causal interaction,diagnostic usage,unassigned	2,3,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29726992&form=6&db=m	Interaction of AIP with protein kinase A (cAMP-dependent protein kinase).	ongoing research,unassigned	1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133010&form=6&db=m	CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31908303&form=6&db=m	Second-line therapies in advanced biliary tract cancers.	unassigned	-	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32978717&form=6&db=m	Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.	causal interaction,ongoing research,unassigned	4,2,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479856&form=6&db=m	Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.	causal interaction,unassigned	3,0	
2.7.11.11	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33776926&form=6&db=m	Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.	causal interaction,unassigned	4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=211793&form=6&db=m	The isozyme pattern of cyclic AMP-dependent protein kinase and the distribution of a cervicovaginal antigen in experimental carcinoma of the cervix uteri of mice.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1331075&form=6&db=m	Redundant regulation of urokinase plasminogen activator transcription by the two major isozymes of cAMP-dependent protein kinase.	ongoing research,unassigned	3,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1338409&form=6&db=m	Expression of a mutant regulatory subunit of cAMP-dependent protein kinase in the Caco-2 human colonic carcinoma cell line.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1338568&form=6&db=m	Cross-activation: overriding cAMP/cGMP selectivities of protein kinases in tissues.	unassigned	-	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3937830&form=6&db=m	Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma.	causal interaction,diagnostic usage,ongoing research,unassigned	3,3,1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3978625&form=6&db=m	Type I and II cyclic adenosine 3':5'-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas.	causal interaction,diagnostic usage,ongoing research,unassigned	4,1,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7529238&form=6&db=m	Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8654392&form=6&db=m	Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.	causal interaction,ongoing research,unassigned	3,3,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943230&form=6&db=m	Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9419412&form=6&db=m	Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.	unassigned	-	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9678244&form=6&db=m	Subcellular distribution of the R-subunits of cAMP-dependent protein kinase in LS-174T human colon carcinoma cells.	diagnostic usage,ongoing research,unassigned	1,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10999726&form=6&db=m	Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11600145&form=6&db=m	Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11743651&form=6&db=m	Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumors.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273247&form=6&db=m	Two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas.	diagnostic usage,ongoing research,unassigned	3,1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16449643&form=6&db=m	Tumorigenesis suppressor pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.	causal interaction,ongoing research,therapeutic application,unassigned	2,1,1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18022554&form=6&db=m	Current immunotherapeutic strategies in renal cell carcinoma.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955398&form=6&db=m	Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,3,4	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22772063&form=6&db=m	Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23105117&form=6&db=m	Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25547910&form=6&db=m	Molecular foundations for personalized therapy in prostate cancer.	causal interaction,diagnostic usage,unassigned	4,2,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25698061&form=6&db=m	DNAJB1-PRKACA is specific for fibrolamellar carcinoma.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,1,1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27015136&form=6&db=m	Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss.	causal interaction,diagnostic usage,therapeutic application,unassigned	2,3,1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27932759&form=6&db=m	[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].	diagnostic usage,ongoing research,unassigned	2,3,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28304380&form=6&db=m	Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.	therapeutic application,unassigned	1,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28862261&form=6&db=m	Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,4,1,4	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881569&form=6&db=m	Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205368&form=6&db=m	Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.	causal interaction,unassigned	2,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222914&form=6&db=m	Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,2,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30015771&form=6&db=m	REVERSIBLE RETINAL TOXICITY IN A PATIENT TAKING AXITINIB.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297384&form=6&db=m	Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,3,0	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597357&form=6&db=m	Update on the pathology of liver neoplasms.	unassigned	-	
2.7.11.11	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832094&form=6&db=m	Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
2.7.11.11	Carcinoma, Ehrlich Tumor	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1818438&form=6&db=m	The in vitro effects of glycyrrhizin and the derivatives of glycyrrhetinic acid on the activity of cAMP-dependent protein kinase and phosphorylation of cellular polypeptide by the kinase from Ehrlich ascites tumor cells.	diagnostic usage,ongoing research,unassigned	3,3,0	
2.7.11.11	Carcinoma, Ehrlich Tumor	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m	Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Carcinoma, Embryonal	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6274870&form=6&db=m	Effect of retinoic acid treatment of F9 embryonal carcinoma cells on the activity and distribution of cyclic AMP-dependent protein kinase.	ongoing research,therapeutic application,unassigned	3,3,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2548485&form=6&db=m	Modulation of nuclear cyclic AMP-dependent protein kinase in dibutyryl cyclic AMP-treated rat H4IIE hepatoma cells.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557826&form=6&db=m	Cloning and expression in Escherichia coli of a rat hepatoma cell cDNA coding for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	ongoing research,therapeutic application,unassigned	3,2,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833520&form=6&db=m	Phosphorylation of beta-glucuronidases from human normal liver and hepatoma by cAMP-dependent protein kinase.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,2,4,1	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2838406&form=6&db=m	[Cancer-associated alterations of human hepatocellular carcinoma beta-glucuronidase--study on phosphorylation by 3', 5'-cyclic AMP dependent-protein kinase]	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,2,3,1	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856413&form=6&db=m	Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.	ongoing research,unassigned	3,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2993318&form=6&db=m	Localization of nuclear subunits of cyclic AMP-dependent protein kinase by the immunocolloidal gold method.	therapeutic application,unassigned	2,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3007246&form=6&db=m	Insulin decreases H4IIE cell PEPCK mRNA by a mechanism that does not involve cAMP.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3007508&form=6&db=m	Cytochemical identification of the regulatory subunit of the cAMP-dependent protein kinase by use of fluorescently labeled catalytic subunit. Examination of protein kinase dissociation in hepatoma cells responding to 8-Br-cAMP stimulation.	ongoing research,unassigned	3,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3568986&form=6&db=m	[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6110670&form=6&db=m	Induction of tyrosine aminotransferase in H-35 hepatoma cells by cAMP captured in phospholipid vesicles.	ongoing research,unassigned	2,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6124549&form=6&db=m	Inhibition of hepatoma cell growth by analogs of adenosine and cyclic AMP and the influence of enzymes in mammalian sera.	unassigned	-	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6131900&form=6&db=m	Direct evidence that the protein kinase catalytic subunit mediates the effects of cAMP on tyrosine aminotransferase synthesis.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6288732&form=6&db=m	Direct cytochemical localization of catalytic subunits dissociated from cAMP-dependent protein kinase in Reuber H-35 hepatoma cells. I. Development and validation of fluorescinated inhibitor.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6288733&form=6&db=m	Direct cytochemical localization of catalytic subunits dissociated from cAMP-dependent protein kinase in Reuber H-35 hepatoma cells. II. Temporal and spatial kinetics.	causal interaction,ongoing research,therapeutic application,unassigned	1,4,1,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7843740&form=6&db=m	Beta-adrenergic receptors and angiotensinogen gene expression in mouse hepatoma cells in vitro.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8402589&form=6&db=m	Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.	causal interaction,diagnostic usage,ongoing research,unassigned	4,3,1,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259987&form=6&db=m	Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.	ongoing research,unassigned	4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809746&form=6&db=m	Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12143039&form=6&db=m	Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells.	diagnostic usage,unassigned	3,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15373827&form=6&db=m	HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling.	unassigned	-	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16824661&form=6&db=m	In vivo footprinting of the carbamoylphosphate synthetase I cAMP-response unit indicates important roles for FoxA and PKA in formation of the enhanceosome.	unassigned	-	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18019715&form=6&db=m	A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity.	causal interaction,unassigned	1,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556896&form=6&db=m	Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells.	causal interaction,ongoing research,unassigned	4,4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22052684&form=6&db=m	Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma.	unassigned	-	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23255113&form=6&db=m	Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23511482&form=6&db=m	PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.	causal interaction,unassigned	1,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25523445&form=6&db=m	An inhibitory role of NEK6 in TGF?/Smad signaling pathway.	ongoing research,unassigned	2,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25698061&form=6&db=m	DNAJB1-PRKACA is specific for fibrolamellar carcinoma.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,1,1,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26482853&form=6&db=m	A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26489647&form=6&db=m	Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.	causal interaction,unassigned	4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26517516&form=6&db=m	Identification of the ?-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,3,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356961&form=6&db=m	2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,1,4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28861148&form=6&db=m	A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28862261&form=6&db=m	Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,4,1,4	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29335433&form=6&db=m	Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.	unassigned	-	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30905674&form=6&db=m	Structures of the PKA RI? Holoenzyme with the FLHCC Driver J-PKAc? or Wild-Type PKAc?.	unassigned	-	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31269749&form=6&db=m	A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish.	causal interaction,unassigned	4,0	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33370777&form=6&db=m	Structural analyses of the PKA RII? holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.	unassigned	-	
2.7.11.11	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34340705&form=6&db=m	MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated ?-catenin/ABCB1 signaling pathway.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Carcinoma, Non-Small-Cell Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27932759&form=6&db=m	[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].	diagnostic usage,ongoing research,unassigned	2,3,0	
2.7.11.11	Carcinoma, Non-Small-Cell Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29493460&form=6&db=m	Molecular Modeling, Docking, Dynamics and simulation of Gefitinib and its derivatives with EGFR in Non-Small Cell Lung Cancer.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Carcinoma, Non-Small-Cell Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32792859&form=6&db=m	Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation.	ongoing research,therapeutic application,unassigned	2,4,0	
2.7.11.11	Carcinoma, Non-Small-Cell Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33185028&form=6&db=m	Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: Exposure-Response Analyses of Pivotal ALTA Study.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,1,3,0	
2.7.11.11	Carcinoma, Renal Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175550&form=6&db=m	The serine proteinase thrombin promotes migration of human renal carcinoma cells by a PKA-dependent mechanism.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Carcinoma, Renal Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18022554&form=6&db=m	Current immunotherapeutic strategies in renal cell carcinoma.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Carcinoma, Renal Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19442041&form=6&db=m	Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Carcinoma, Renal Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30015771&form=6&db=m	REVERSIBLE RETINAL TOXICITY IN A PATIENT TAKING AXITINIB.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Carcinoma, Squamous Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693923&form=6&db=m	cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.	ongoing research,unassigned	2,0	
2.7.11.11	Carcinoma, Squamous Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6323445&form=6&db=m	cAMP-dependent protein kinase stimulates epidermal growth factor-dependent phosphorylation of epidermal growth factor receptors.	diagnostic usage,ongoing research,unassigned	3,3,0	
2.7.11.11	Carcinoma, Squamous Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955398&form=6&db=m	Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,3,4	
2.7.11.11	Carcinoma, Squamous Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27932759&form=6&db=m	[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].	diagnostic usage,ongoing research,unassigned	2,3,0	
2.7.11.11	Carcinoma, Squamous Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33042258&form=6&db=m	Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [177Lu]Lu-PP-F11N.	ongoing research,unassigned	3,0	
2.7.11.11	Carcinoma, Squamous Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832094&form=6&db=m	Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
2.7.11.11	Cardiomegaly	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=210840&form=6&db=m	Alterations in activities of cyclic nucleotide systems and in beta-adrenergic receptor-mediated activation of cyclic AMP-dependent protein kinase during progression and regression of isoproterenol-induced cardiac hypertrophy.	causal interaction,diagnostic usage,unassigned	1,1,0	
2.7.11.11	Cardiomegaly	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8287442&form=6&db=m	Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Cardiomegaly	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8762044&form=6&db=m	Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,2,3,0	
2.7.11.11	Cardiomegaly	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110410&form=6&db=m	Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.	unassigned	-	
2.7.11.11	Cardiomegaly	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31725448&form=6&db=m	Effect of endostatin overexpression on angiotensin II-induced cardiac hypertrophy in rats.	causal interaction,unassigned	2,0	
2.7.11.11	Cardiomyopathies	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787061&form=6&db=m	TNNI3K in cardiovascular disease and prospects for therapy.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cardiomyopathy, Dilated	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7842467&form=6&db=m	cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium.	causal interaction,unassigned	3,0	
2.7.11.11	Cardiomyopathy, Dilated	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8973767&form=6&db=m	Activation of cyclic AMP-dependent protein kinase in cardiomyocytes by anti-beta 1-adrenoceptor autoantibodies from patients with idiopathic dilated cardiomyopathy.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Cardiomyopathy, Dilated	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10435018&form=6&db=m	Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.	ongoing research,unassigned	4,0	
2.7.11.11	Cardiomyopathy, Dilated	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16124995&form=6&db=m	Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy.	causal interaction,unassigned	3,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203783&form=6&db=m	Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,2,1	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12424709&form=6&db=m	Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.	unassigned	-	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12641630&form=6&db=m	GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24.	causal interaction,unassigned	1,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15591278&form=6&db=m	A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288019&form=6&db=m	Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16569736&form=6&db=m	PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex.	causal interaction,unassigned	4,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18760947&form=6&db=m	Case report of familial Carney complex due to novel frameshift mutation c.597del C (p.Phe200LeufsX6) in PRKAR1A.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19738044&form=6&db=m	Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.	unassigned	-	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111774&form=6&db=m	How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?	causal interaction,unassigned	3,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21852354&form=6&db=m	Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498419&form=6&db=m	Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27943004&form=6&db=m	Carney complex: A familial lentiginosis predisposing to a variety of tumors.	causal interaction,unassigned	3,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29162369&form=6&db=m	Carney complex review: Genetic features.	causal interaction,unassigned	4,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29222914&form=6&db=m	Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,2,0	
2.7.11.11	Carney Complex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821937&form=6&db=m	Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.	causal interaction,unassigned	3,0	
2.7.11.11	Cerebral Infarction	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568255&form=6&db=m	Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice.	ongoing research,therapeutic application,unassigned	1,4,0	
2.7.11.11	Cholangiocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31255945&form=6&db=m	FGFR2 genomic aberrations: Achilles heel in the management of advanced cholangiocarcinoma.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=212191&form=6&db=m	Regulation of S49 lymphoma cell growth by cyclic adenosine 3':5'-monophosphate.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=226345&form=6&db=m	Effects of cholera toxin on thyroid cyclic AMP-dependent protein kinase and ornithine decarboxylase activities.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,2,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1370599&form=6&db=m	Regulation of CTP:phosphocholine cytidylyltransferase activity and phosphorylation in rat hepatocytes: lack of effect of elevated cAMP levels.	unassigned	-	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1653071&form=6&db=m	Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,3,4,1	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667677&form=6&db=m	Activation of locus coeruleus (LC) neurones by cholera toxin: mediation by cAMP-dependent protein kinase.	ongoing research,therapeutic application,unassigned	4,2,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693923&form=6&db=m	cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.	ongoing research,unassigned	2,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2429199&form=6&db=m	[Modulation of calcium conductance of the somatic membrane of sensory neurons of the rat upon activation of the adenylate cyclase system]	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2437113&form=6&db=m	Inhibition of choriogonadotropin-activated steroidogenesis in cultured Leydig tumor cells by the Rp diastereoisomer of adenosine 3',5'-cyclic phosphorothioate.	therapeutic application,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538415&form=6&db=m	Cholera toxin induces cAMP-independent degradation of Gs.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,1,1	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2560108&form=6&db=m	Inhibition by the protein kinase inhibitors, isoquinolinesulfonamides, of fluid accumulation induced by Escherichia coli heat-stable enterotoxin, 8-bromo-cGMP and 8-bromo-cAMP in suckling mice.	unassigned	-	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2828508&form=6&db=m	Stimulation of chick adrenal steroidogenesis by avian parathyroid hormone.	diagnostic usage,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2925955&form=6&db=m	Influence of cholera toxin (an adenylate cyclase activator) on deoxyribonucleic acid synthesis of bovine mammary tissue in vitro and in athymic nude mice.	causal interaction,ongoing research,therapeutic application,unassigned	1,4,4,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2985223&form=6&db=m	The regulation of steroidogenesis is different in the two types of ovine luteal cells.	unassigned	-	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988884&form=6&db=m	Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.	causal interaction,unassigned	4,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3121596&form=6&db=m	Relationship of phosphorylation and ADP-ribosylation using a synthetic peptide as a model substrate.	therapeutic application,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6092042&form=6&db=m	Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase activity in rodent pituitary tissue: possible role in cAMP-dependent hormone secretion.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6098816&form=6&db=m	Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6262249&form=6&db=m	Modification of steroidogenesis in a mouse adrenal cell line (Y-1) transformed by simian adenovirus SA-7.	ongoing research,unassigned	2,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6273189&form=6&db=m	Calcium-mediated transduction of the hormonal message in meiosis reinitiation of starfish oocytes: modulation following injection of cholera toxin and cAMP-dependent protein kinase.	therapeutic application,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6276407&form=6&db=m	Effects of cholinergic and adrenergic agonists on phosphorylation of a 165,000-dalton myofibrillar protein in intact cardiac muscle.	unassigned	-	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6284819&form=6&db=m	Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.	ongoing research,therapeutic application,unassigned	2,2,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6294128&form=6&db=m	Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.	ongoing research,unassigned	3,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6303409&form=6&db=m	The effect of cyclic nucleotides and cholera toxin on in vivo and in vitro phosphorylation of small intestinal brush border membranes.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7016632&form=6&db=m	The pure inhibitor of cAMP-dependent protein kinase initiates Xenopus laevis meiotic maturation. A 4-step scheme for meiotic maturation.	therapeutic application,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7792294&form=6&db=m	Evidence of heterotrimeric G-protein involvement in regulated exocytosis from permeabilized pancreatic acini.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8144566&form=6&db=m	Effect of ADP-ribosylation factor amino-terminal deletions on its GTP-dependent stimulation of cholera toxin activity.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,2,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8306942&form=6&db=m	Epidermal growth factor modulates cholera toxin induced mammary gland development.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,2	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8471634&form=6&db=m	Differential effects of activation of protein kinase C and cyclic-AMP-dependent protein kinase on sodium-dependent phosphate uptake in NIH 3T3 cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9636365&form=6&db=m	The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage.	therapeutic application,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671965&form=6&db=m	Acute and chronic regulation of Na+/K+-ATPase transport activity in the RN22 Schwann cell line in response to stimulation of cyclic AMP production.	ongoing research,therapeutic application,unassigned	1,3,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18253052&form=6&db=m	A crucial role for cAMP and protein kinase A in D1 dopamine receptor regulated intracellular calcium transients.	therapeutic application,unassigned	1,0	
2.7.11.11	Cholera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25786687&form=6&db=m	Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling.	ongoing research,unassigned	3,0	
2.7.11.11	Chondroma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421483&form=6&db=m	Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.	causal interaction,unassigned	2,0	
2.7.11.11	Chondrosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6477653&form=6&db=m	Phosphorylation of proteoglycans from human articular cartilage by a cAMP-dependent protein kinase.	ongoing research,unassigned	2,0	
2.7.11.11	Choriocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2744214&form=6&db=m	Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAs.	ongoing research,unassigned	1,0	
2.7.11.11	Choriocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850967&form=6&db=m	Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.	ongoing research,unassigned	4,0	
2.7.11.11	Choroidal Neovascularization	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10362799&form=6&db=m	Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor.	causal interaction,therapeutic application,unassigned	2,4,0	
2.7.11.11	Coinfection	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11604230&form=6&db=m	Specific DNA binding and transactivation potential of recombinant, purified Stat5.	ongoing research,unassigned	1,0	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6282471&form=6&db=m	Adenosine 3',5'-cyclic monophosphate dependent and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer.	causal interaction,unassigned	4,0	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10425310&form=6&db=m	Synergistic growth inhibition and induction of apoptosis by a novel mixed backbone antisense oligonucleotide targeting CRIPTO in combination with C225 anti-EGFR monoclonal antibody and 8-Cl-cAMP in human GEO colon cancer cells.	ongoing research,unassigned	3,0	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12677090&form=6&db=m	Inhibition of cyclin A kinase activity in E2F-1 chemogene therapy of colon cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,1,3,4	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342696&form=6&db=m	BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.	causal interaction,unassigned	3,0	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899904&form=6&db=m	Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,1,0	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22369945&form=6&db=m	Phosphorylation of ?-catenin at serine 663 regulates its transcriptional activity.	ongoing research,therapeutic application,unassigned	1,1,0	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31286799&form=6&db=m	ASF1A regulates H4Y72 phosphorylation and promotes autophagy in colon cancer cells via a kinase activity.	unassigned	-	
2.7.11.11	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32180471&form=6&db=m	Expression of Concern: ASF1A regulates H4Y72 phosphorylation and promotes autophagy in colon cancer cells via a kinase activity.	unassigned	-	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9374525&form=6&db=m	Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.	therapeutic application,unassigned	1,0	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407877&form=6&db=m	Lessons from phase III clinical trials on anti-VEGF therapy for cancer.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227403&form=6&db=m	Rapid determination of AKAP12 promoter methylation levels in peripheral blood using methylation-sensitive high resolution melting (MS-HRM) analysis: application in colorectal cancer.	diagnostic usage,ongoing research,unassigned	4,3,0	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23676219&form=6&db=m	HIPK1 drives p53 activation to limit colorectal cancer cell growth.	causal interaction,unassigned	4,0	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900113&form=6&db=m	New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26136684&form=6&db=m	Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,2,4	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470380&form=6&db=m	Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28148261&form=6&db=m	Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.	causal interaction,unassigned	2,0	
2.7.11.11	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28669946&form=6&db=m	[Expression of cAMP-dependent protein kinase inhibitor beta in colorectal carcinoma and its clinical significance].	causal interaction,diagnostic usage,ongoing research,unassigned	1,4,2,0	
2.7.11.11	Craniocerebral Trauma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541831&form=6&db=m	[The cAMP content and cAMP-dependent protein kinase activity in the brain of rabbits in the dynamics of moderate craniocerebral trauma]	therapeutic application,unassigned	1,0	
2.7.11.11	Cryopyrin-Associated Periodic Syndromes	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20940146&form=6&db=m	Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,1,0	
2.7.11.11	Cryptosporidiosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634204&form=6&db=m	Papers of note in Nature546 (7658).	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20548949&form=6&db=m	Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.	unassigned	-	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24700472&form=6&db=m	Activating Hotspot L205R Mutation in PRKACA and Adrenal Cushing's Syndrome.	causal interaction,unassigned	2,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24751881&form=6&db=m	Neuroendocrine cancer. An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics.	causal interaction,unassigned	2,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24855271&form=6&db=m	Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.	unassigned	-	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25057884&form=6&db=m	Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,3,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25069672&form=6&db=m	Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,2,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25449630&form=6&db=m	Germline PRKACA amplification leads to Cushing syndrome caused by 3 adrenocortical pathologic phenotypes.	ongoing research,therapeutic application,unassigned	1,1,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871963&form=6&db=m	Protein kinase A defects and cortisol-producing adrenal tumors.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,3,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26130139&form=6&db=m	Carney complex: an update.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,2,2,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26139209&form=6&db=m	cAMP signaling in cortisol-producing adrenal adenoma.	causal interaction,diagnostic usage,unassigned	4,1,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26965378&form=6&db=m	A genetic and molecular update on adrenocortical causes of Cushing syndrome.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27389594&form=6&db=m	Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.	causal interaction,unassigned	4,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27813054&form=6&db=m	Mechanisms of Aberrant PKA Activation by C? Subunit Mutations.	causal interaction,diagnostic usage,unassigned	3,3,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632813&form=6&db=m	Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.	unassigned	-	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30615103&form=6&db=m	Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.	causal interaction,unassigned	1,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31276155&form=6&db=m	Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.	causal interaction,diagnostic usage,unassigned	3,3,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31489371&form=6&db=m	Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.	diagnostic usage,unassigned	3,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33608270&form=6&db=m	PKA C? subunit mutation triggers caspase-dependent RII? subunit degradation via Ser114 phosphorylation.	causal interaction,unassigned	3,0	
2.7.11.11	Cushing Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520814&form=6&db=m	Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.	causal interaction,unassigned	3,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1374403&form=6&db=m	Cyclic AMP-dependent protein kinase activation of cystic fibrosis transmembrane conductance regulator chloride channels in planar lipid bilayers.	ongoing research,unassigned	3,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1377674&form=6&db=m	Phosphorylation of the cystic fibrosis transmembrane conductance regulator.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1379720&form=6&db=m	Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1698296&form=6&db=m	Fatty acids inhibit apical membrane chloride channels in airway epithelia.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2448645&form=6&db=m	Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3479018&form=6&db=m	Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.	causal interaction,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511414&form=6&db=m	Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7529238&form=6&db=m	Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7529497&form=6&db=m	Mutation of potential phosphorylation sites in the recombinant R domain of the cystic fibrosis transmembrane conductance regulator has significant effects on domain conformation.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7530719&form=6&db=m	cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation.	causal interaction,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7534234&form=6&db=m	Abnormal subcellular localization of mutated CFTR protein in a cystic fibrosis epithelial cell line.	therapeutic application,unassigned	2,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7543684&form=6&db=m	Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity.	ongoing research,therapeutic application,unassigned	3,2,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7578613&form=6&db=m	Cyclic AMP-related and cation-affected human platelet chloride transport regulation.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7690753&form=6&db=m	Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631756&form=6&db=m	Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8943230&form=6&db=m	Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346969&form=6&db=m	Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel.	therapeutic application,unassigned	2,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9530114&form=6&db=m	Type II protein kinase A regulates CFTR in airway, pancreatic, and intestinal cells.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10075649&form=6&db=m	A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409120&form=6&db=m	Syntaxin 1A inhibits regulated CFTR trafficking in xenopus oocytes.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600928&form=6&db=m	Regulation of the ROMK channel: interaction of the ROMK with associate proteins.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799517&form=6&db=m	Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11053017&form=6&db=m	Contribution of R domain phosphoserines to the function of CFTR studied in Fischer rat thyroid epithelia.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11237860&form=6&db=m	Multiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulator.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11950844&form=6&db=m	A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939393&form=6&db=m	Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066992&form=6&db=m	Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657296&form=6&db=m	Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.	therapeutic application,unassigned	1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108316&form=6&db=m	Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581860&form=6&db=m	The formation of the cAMP/protein kinase A-dependent annexin 2 S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18694937&form=6&db=m	Regulation of CFTR Trafficking by Its R Domain.	unassigned	-	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20308611&form=6&db=m	Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells.	therapeutic application,unassigned	2,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22278744&form=6&db=m	Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis.	ongoing research,unassigned	3,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226244&form=6&db=m	cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098609&form=6&db=m	Correction: cAMP/Protein Kinase A Activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP Release from Rat Skeletal Muscle during Low pH or Contractions.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Cystic Fibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25903037&form=6&db=m	Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Cysticercosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24161749&form=6&db=m	Immunodiagnosis of porcine cysticercosis: identification of candidate antigens through immunoproteomics.	diagnostic usage,therapeutic application,unassigned	3,1,0	
2.7.11.11	Cysticercosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28359828&form=6&db=m	TsPKA-r: a potential immunodiagnostic antigen for the detection of porcine cysticercosis.	diagnostic usage,ongoing research,therapeutic application,unassigned	4,3,1,0	
2.7.11.11	Cysts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10767293&form=6&db=m	Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.	causal interaction,unassigned	1,0	
2.7.11.11	Cysts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26202352&form=6&db=m	The Effect of cAMP-PKA Activation on TGF-?1-Induced Profibrotic Signaling.	causal interaction,ongoing research,unassigned	3,2,0	
2.7.11.11	Dehydration	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2986732&form=6&db=m	[Activity of cAMP-dependent protein kinases and cAMP-binding proteins from rat renal cytosol upon dehydration.]	causal interaction,unassigned	4,0	
2.7.11.11	Dehydration	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9203370&form=6&db=m	Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs.	diagnostic usage,therapeutic application,unassigned	3,1,0	
2.7.11.11	Dehydration	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11334639&form=6&db=m	Stimulation of CFU-f formation by prostaglandin E(2) is mediated in part by its degradation product, prostaglandin A(2).	unassigned	-	
2.7.11.11	Dehydration	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11352224&form=6&db=m	Stimulation of CFU-f formation by prostaglandin E2 is mediated in part by its degradation product, prostaglandin A2.	unassigned	-	
2.7.11.11	Dementia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22269890&form=6&db=m	A Pilot Study Examining Associations between DYRK1A and ?-Synuclein Dementias.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,2,3,4	
2.7.11.11	Dementia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26104286&form=6&db=m	CDK5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemia.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Dermatitis, Exfoliative	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2566733&form=6&db=m	A cAMP binding abnormality in psoriasis.	unassigned	-	
2.7.11.11	Dermatofibrosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23777493&form=6&db=m	Pityriasis rubra pilaris-like reaction induced by imatinib.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Dermatofibrosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30950098&form=6&db=m	A novel MAP3K7CL-ERG fusion in a molecularly confirmed case of dermatofibrosarcoma protuberans with fibrosarcomatous transformation.	ongoing research,unassigned	1,0	
2.7.11.11	Diabetes Mellitus	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773997&form=6&db=m	Bioactive compounds in plant materials for the prevention of diabetesand obesity.	unassigned	-	
2.7.11.11	Diabetes Mellitus, Type 1	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10912450&form=6&db=m	The role of taurine in the pathogenesis of the cardiomyopathy of insulin-dependent diabetes mellitus.	unassigned	-	
2.7.11.11	Diabetes Mellitus, Type 2	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889175&form=6&db=m	Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.	ongoing research,unassigned	4,0	
2.7.11.11	Diabetes Mellitus, Type 2	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773997&form=6&db=m	Bioactive compounds in plant materials for the prevention of diabetesand obesity.	unassigned	-	
2.7.11.11	Diabetic Cardiomyopathies	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630371&form=6&db=m	Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Down Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733250&form=6&db=m	Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome.	causal interaction,unassigned	2,0	
2.7.11.11	Down Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19265526&form=6&db=m	Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology.	causal interaction,unassigned	1,0	
2.7.11.11	Down Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21185805&form=6&db=m	Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A).	causal interaction,unassigned	1,0	
2.7.11.11	Down Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23218601&form=6&db=m	Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.	causal interaction,unassigned	1,0	
2.7.11.11	Down Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23920041&form=6&db=m	DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.	causal interaction,diagnostic usage,unassigned	4,3,0	
2.7.11.11	Down Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34109727&form=6&db=m	DYRK1A phosphorylates MEF2D and decreases its transcriptional activity.	ongoing research,unassigned	1,0	
2.7.11.11	Dyskinesias	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753408&form=6&db=m	Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism.	causal interaction,unassigned	3,0	
2.7.11.11	Dyspnea	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379451&form=6&db=m	Cytomegalovirus-induced Hemorrhagic Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) on Dasatinib as an Upfront Therapy.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,4,0	
2.7.11.11	Endometrial Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33867147&form=6&db=m	PP2A and E3 ubiquitin ligase deficiencies: Seminal biological drivers in endometrial cancer.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,1,1,0	
2.7.11.11	Endometriosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973079&form=6&db=m	Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women.	causal interaction,diagnostic usage,unassigned	4,2,0	
2.7.11.11	Epilepsy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184196&form=6&db=m	Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.	ongoing research,unassigned	2,0	
2.7.11.11	Epilepsy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29746776&form=6&db=m	From Cancer to Pain Target by Automated Selectivity Inversion of a Clinical Candidate.	causal interaction,unassigned	2,0	
2.7.11.11	Exanthema	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379451&form=6&db=m	Cytomegalovirus-induced Hemorrhagic Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) on Dasatinib as an Upfront Therapy.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,4,0	
2.7.11.11	Familial Mediterranean Fever	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33037005&form=6&db=m	Fast diagnostic test for familial Mediterranean fever based on a kinase inhibitor.	diagnostic usage,therapeutic application,unassigned	4,4,0	
2.7.11.11	Fanconi Anemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27398318&form=6&db=m	Aurora A kinase is required for activation of the Fanconi anemia/BRCA pathway upon DNA damage.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Fibrosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10099827&form=6&db=m	E2F-1 has properties of a radiosensitizer and its regulation by cyclin A kinase is required for cell survival of fibrosarcoma cells lacking p53.	causal interaction,ongoing research,therapeutic application,unassigned	2,4,1,0	
2.7.11.11	Fibrosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341099&form=6&db=m	?2-Adrenoceptor Agonists Promote ERK1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-driven Signaling Independently of ?-Arrestin 2.	causal interaction,unassigned	4,0	
2.7.11.11	Focal Nodular Hyperplasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597357&form=6&db=m	Update on the pathology of liver neoplasms.	unassigned	-	
2.7.11.11	Folliculitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23612033&form=6&db=m	Perforating Folliculitis in a Patient Treated With Nilotinib: A Further Evidence of C-kit Involvement.	ongoing research,therapeutic application,unassigned	2,3,0	
2.7.11.11	Frontotemporal Lobar Degeneration	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29409526&form=6&db=m	Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.	causal interaction,unassigned	3,0	
2.7.11.11	Gastrointestinal Stromal Tumors	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19442041&form=6&db=m	Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Gastrointestinal Stromal Tumors	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23777493&form=6&db=m	Pityriasis rubra pilaris-like reaction induced by imatinib.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Giant Cell Tumor of Tendon Sheath	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043474&form=6&db=m	Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Glaucoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30541912&form=6&db=m	Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma.	unassigned	-	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6297726&form=6&db=m	Multiple forms of protein kinase from normal human brain and glioblastoma.	ongoing research,unassigned	3,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9617483&form=6&db=m	Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604283&form=6&db=m	The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,2,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15952716&form=6&db=m	Proteomic studies on low- and high-grade human brain astrocytomas.	causal interaction,unassigned	3,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16126335&form=6&db=m	An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,1,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27138904&form=6&db=m	Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells.	ongoing research,unassigned	3,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27816996&form=6&db=m	Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma.	causal interaction,unassigned	4,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28292440&form=6&db=m	A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.	causal interaction,therapeutic application,unassigned	2,3,0	
2.7.11.11	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31328883&form=6&db=m	An autocrine ActivinB mechanism drives TGF?/Activin signaling in Group 3 medulloblastoma.	therapeutic application,unassigned	3,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=177883&form=6&db=m	External cyclic AMP-dependent protein kinase activity in rat C-6 glioma cells.	ongoing research,unassigned	3,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=231167&form=6&db=m	Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma X glioma hybrid cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3986796&form=6&db=m	Characterization of cyclic adenosine 3':5'-monophosphate-dependent protein kinase isozymes in normal and neoplastic fetal rat brain cells.	ongoing research,unassigned	4,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6244301&form=6&db=m	Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.	unassigned	-	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6244389&form=6&db=m	beta Adrenergic receptor-mediated regulation of cyclic nucleotide phosphodiesterase in C6 glioma cells: vinblastine blockade of isoproterenol induction.	ongoing research,unassigned	2,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8392466&form=6&db=m	Differential effects of two structurally related N6-substituted cAMP analogues on C6 glioma cells.	unassigned	-	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8910614&form=6&db=m	The role of protein kinase C in cellular tolerance to ethanol.	therapeutic application,unassigned	3,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9245701&form=6&db=m	Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.	ongoing research,unassigned	2,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9484714&form=6&db=m	Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,4,1,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388552&form=6&db=m	CXCR4 is a major chemokine receptor on glioma cells and mediates their survival.	unassigned	-	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432276&form=6&db=m	The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16385577&form=6&db=m	Rho/ROCK pathway as a target of tumor therapy.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,2,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16891468&form=6&db=m	Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,3,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708342&form=6&db=m	Selective distribution of protein kinase A regulatory subunit RII{alpha} in rodent gliomas.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,4,1,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172575&form=6&db=m	MicroRNA 335 Is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP/Protein Kinase A Pathway.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26165472&form=6&db=m	Activation of death-associated protein kinase in human peritumoral tissue: A potential therapeutic target.	ongoing research,unassigned	1,0	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640193&form=6&db=m	Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.	unassigned	-	
2.7.11.11	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33885249&form=6&db=m	Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Goiter	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=41580&form=6&db=m	Properties of cyclic AMP-dependent protein kinase in normal and goitrous rat thyroid gland.	diagnostic usage,unassigned	3,0	
2.7.11.11	Goiter	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=225202&form=6&db=m	TSH and DBC action on cAMP-dependent protein kinase activities in cell cultures of human non-toxic goiters.	ongoing research,unassigned	3,0	
2.7.11.11	Gout	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27169898&form=6&db=m	ALPK1 phosphorylates myosin IIA modulating TNF-? trafficking in gout flares.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Gray Platelet Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8199024&form=6&db=m	Abnormal cAMP-induced phosphorylation of rap 1 protein in grey platelet syndrome platelets.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Growth Hormone-Secreting Pituitary Adenoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225481&form=6&db=m	Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.	causal interaction,unassigned	1,0	
2.7.11.11	Heart Arrest	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26909957&form=6&db=m	Cyclic adenosine monophosphate-protein kinase A signal pathway may be involved in pulmonary aquaporin-5 expression in ischemia/reperfusion rats following deep hypothermia cardiac arrest.	causal interaction,unassigned	1,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7654184&form=6&db=m	Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach.	diagnostic usage,ongoing research,unassigned	1,1,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7842467&form=6&db=m	cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium.	causal interaction,unassigned	3,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8593748&form=6&db=m	Signalling pathways in cardiac failure.	causal interaction,unassigned	3,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10578521&form=6&db=m	Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,1,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10603952&form=6&db=m	cAMP-dependent protein kinase A-stimulated sarcoplasmic reticulum function in heart failure.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,2,2,1	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18759454&form=6&db=m	Apoptosis signal-regulating kinase 1 attenuates atrial natriuretic peptide secretion.	ongoing research,unassigned	1,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21852354&form=6&db=m	Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787061&form=6&db=m	TNNI3K in cardiovascular disease and prospects for therapy.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27302402&form=6&db=m	Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28976966&form=6&db=m	Hippo pathway deficiency reverses systolic heart failure after infarction.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Hematologic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19018667&form=6&db=m	Oxidative stress by targeted agents promotes cytotoxicity in hematological malignancies.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Hematologic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27892929&form=6&db=m	A review of kinase fusions in melanocytic tumors.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Hematologic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31911485&form=6&db=m	Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Hepatitis B	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2158690&form=6&db=m	Expression of hepatitis B virus core and precore antigens in insect cells and characterization of a core-associated kinase activity.	causal interaction,unassigned	1,0	
2.7.11.11	Hepatitis B	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114561&form=6&db=m	A kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro.	diagnostic usage,unassigned	3,0	
2.7.11.11	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647104&form=6&db=m	Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9060639&form=6&db=m	Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase.	diagnostic usage,ongoing research,unassigned	2,2,0	
2.7.11.11	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9409782&form=6&db=m	Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10405893&form=6&db=m	Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11413375&form=6&db=m	The inhibition of cAMP-dependent protein kinase by full-length hepatitis C virus NS3/4A complex is due to ATP hydrolysis.	therapeutic application,unassigned	1,0	
2.7.11.11	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19185594&form=6&db=m	The flaviviral methyltransferase is a substrate of Casein Kinase 1.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,3,0	
2.7.11.11	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21858043&form=6&db=m	The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly.	ongoing research,therapeutic application,unassigned	2,4,0	
2.7.11.11	Hepatoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11749725&form=6&db=m	Cold-stimulated increase in a regulatory subunit of cAMP-dependent protein kinase in human hepatoblastoma cells.	ongoing research,unassigned	2,0	
2.7.11.11	Hepatoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27396604&form=6&db=m	Targeting Aurora A kinase with Alisertib (ALS) Induces Autophagy and Cell Cycle Arrest and Increases Chemosensitivity in Hepatoblastoma HepG2 Cells.	causal interaction,unassigned	1,0	
2.7.11.11	Herpes Simplex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981874&form=6&db=m	Expression of the cyclic AMP-dependent protein kinase (PKA) catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Herpes Simplex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8551563&form=6&db=m	Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.	ongoing research,unassigned	3,0	
2.7.11.11	Herpes Simplex	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836380&form=6&db=m	The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.	ongoing research,unassigned	3,0	
2.7.11.11	Herpes Zoster	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19734321&form=6&db=m	N6-substituted cAMP Analogs Inhibit bTREK-1 K+ Channels and Stimulate Cortisol Secretion by a PKA-Independent Mechanism.	therapeutic application,unassigned	1,0	
2.7.11.11	Herpes Zoster	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24418125&form=6&db=m	Thiol-disulfide proteins of stallion epididymal spermatozoa.	therapeutic application,unassigned	1,0	
2.7.11.11	Herpes Zoster	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405879&form=6&db=m	Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.	diagnostic usage,ongoing research,unassigned	3,1,0	
2.7.11.11	HIV Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9657525&form=6&db=m	Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	HIV Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597771&form=6&db=m	Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	HIV Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075533&form=6&db=m	Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP.	causal interaction,unassigned	3,0	
2.7.11.11	Hyperaldosteronism	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270477&form=6&db=m	PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,3,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1722888&form=6&db=m	Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,3,2,2	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8821527&form=6&db=m	Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11790814&form=6&db=m	Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors.	causal interaction,unassigned	4,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16120663&form=6&db=m	cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.	causal interaction,unassigned	3,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564637&form=6&db=m	Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo.	therapeutic application,unassigned	1,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18482991&form=6&db=m	Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization.	causal interaction,unassigned	2,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22331028&form=6&db=m	GRK6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting PI3kinase- and inhibiting p38-signaling.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,3,4,2	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22541444&form=6&db=m	Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.	ongoing research,therapeutic application,unassigned	1,2,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26929333&form=6&db=m	Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.	therapeutic application,unassigned	1,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617945&form=6&db=m	cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain.	causal interaction,ongoing research,therapeutic application,unassigned	3,3,4,0	
2.7.11.11	Hyperalgesia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34000337&form=6&db=m	Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Hyperglycemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24152968&form=6&db=m	The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Hyperglycemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28291959&form=6&db=m	The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.	causal interaction,unassigned	2,0	
2.7.11.11	Hyperhomocysteinemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30062489&form=6&db=m	Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.	therapeutic application,unassigned	1,0	
2.7.11.11	Hyperkalemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12522152&form=6&db=m	WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.	unassigned	-	
2.7.11.11	Hyperpigmentation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766244&form=6&db=m	cAMP-dependent PKA activation as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide.	therapeutic application,unassigned	2,0	
2.7.11.11	Hypersensitivity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815886&form=6&db=m	Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Hypersensitivity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17069754&form=6&db=m	A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9.	therapeutic application,unassigned	1,0	
2.7.11.11	Hypersensitivity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26843647&form=6&db=m	Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.	causal interaction,unassigned	3,0	
2.7.11.11	Hypersensitivity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34492172&form=6&db=m	Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.	causal interaction,unassigned	3,0	
2.7.11.11	Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8842563&form=6&db=m	Selective effect of high arterial pressure in hypertension upon inhibition of cGMP versus cAMP mediated vascular relaxation.	therapeutic application,unassigned	1,0	
2.7.11.11	Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12522152&form=6&db=m	WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.	unassigned	-	
2.7.11.11	Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15110905&form=6&db=m	Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.	causal interaction,unassigned	4,0	
2.7.11.11	Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242606&form=6&db=m	Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357011&form=6&db=m	WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).	therapeutic application,unassigned	1,0	
2.7.11.11	Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30036880&form=6&db=m	Analysis of Genes Related to Angiotensin II-Induced Arterial Injury Using a Time Series Microarray.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Hyperthyroidism	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=200995&form=6&db=m	Cyclic AMP-dependent protein kinase activation in hearts from euthyroid and hyperthyroid rats.	ongoing research,unassigned	3,0	
2.7.11.11	Hyperthyroidism	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2829867&form=6&db=m	Hyperthyroidism affects the activity of a cAMP-dependent protein kinase and protein phosphorylation in heart sarcolemma.	unassigned	-	
2.7.11.11	Hyperthyroidism	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2962871&form=6&db=m	The effect of thyroxine on the calmodulin-dependent (Ca2+-Mg2+)ATPase activity and protein phosphorylation in rabbit fast skeletal muscle sarcolemma.	diagnostic usage,unassigned	1,0	
2.7.11.11	Hypertrophy, Left Ventricular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8762044&form=6&db=m	Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,2,3,0	
2.7.11.11	Hypoglycemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28541532&form=6&db=m	Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia.	causal interaction,unassigned	2,0	
2.7.11.11	Hypoglycemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28596236&form=6&db=m	Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,3,4,3	
2.7.11.11	Hypophosphatemia, Familial	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6274874&form=6&db=m	Cyclic AMP-dependent protein phosphorylation in canine renal brush-border membrane vesicles is associated with decreased phosphate transport.	therapeutic application,unassigned	1,0	
2.7.11.11	Ichthyosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24134817&form=6&db=m	Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.	therapeutic application,unassigned	2,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=170098&form=6&db=m	Protein kinase of bacteriophage T7. 1. Purification.	therapeutic application,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1101258&form=6&db=m	In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.	unassigned	-	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2934987&form=6&db=m	Virus-induced atherosclerosis. Herpesvirus infection alters aortic cholesterol metabolism and accumulation.	unassigned	-	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023653&form=6&db=m	A kinase able to phosphorylate exogenous protein synthesis initiation factor eIF-2 alpha is present in lysates of mengovirus-infected L cells.	unassigned	-	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11518281&form=6&db=m	Signal transduction pathways and apoptosis in bacteria infected chondrocytes.	diagnostic usage,unassigned	2,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11768531&form=6&db=m	Complementation of the Magnaporthe grisea deltacpkA mutation by the Blumeria graminis PKA-c gene: functional genetic analysis of an obligate plant pathogen.	ongoing research,unassigned	2,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12464936&form=6&db=m	Effects of beta-agonists on airway epithelial cells.	causal interaction,ongoing research,unassigned	3,1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500393&form=6&db=m	Ras-dependent oncolysis with an adenovirus VAI mutant.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15100302&form=6&db=m	Increased mitogen-activated protein kinase activity and TNF-alpha production associated with Mycobacterium smegmatis- but not Mycobacterium avium-infected macrophages requires prolonged stimulation of the calmodulin/calmodulin kinase and cyclic AMP/protein kinase A pathways.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254178&form=6&db=m	Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16365679&form=6&db=m	Induction of a cytosolic pyruvate kinase 1 gene during the resistance response to Tobacco mosaic virus in Capsicum annuum.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17376070&form=6&db=m	The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci.	causal interaction,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19880449&form=6&db=m	Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.	therapeutic application,unassigned	3,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19907711&form=6&db=m	Meeting of conventional and unconventional pathways at the TGN.	therapeutic application,unassigned	3,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20081355&form=6&db=m	Helicobacter pylori-induced modification of the  histone H3 phosphorylation status in gastric  epithelial cells reflects its impact on cell cycle  regulation.	diagnostic usage,ongoing research,unassigned	4,3,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20134254&form=6&db=m	The gene fpk1, encoding a cAMP-dependent protein kinase catalytic subunit homolog, is required for hyphal growth, spore germination, and plant infection in Fusarium verticillioides.	therapeutic application,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192838&form=6&db=m	The cAMP signaling pathway in Fusarium verticillioides is important for conidiation, plant infection, and stress responses but not fumonisin production.	unassigned	-	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21772829&form=6&db=m	Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation.	causal interaction,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22144889&form=6&db=m	Two novel transcriptional regulators are essential for infection-related morphogenesis and pathogenicity of the rice blast fungus Magnaporthe oryzae.	therapeutic application,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028825&form=6&db=m	Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus.	unassigned	-	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24028560&form=6&db=m	Coxiella burnetii Exploits Host cAMP-Dependent Protein Kinase Signaling to Promote Macrophage Survival.	diagnostic usage,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24205414&form=6&db=m	Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library.	ongoing research,unassigned	3,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24283208&form=6&db=m	The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,3,2,1	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24450772&form=6&db=m	The cAMP-PKA pathway regulates growth, sexual and asexual differentiation, and pathogenesis in Fusarium graminearum.	causal interaction,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24848114&form=6&db=m	Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,3,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27835919&form=6&db=m	PKA and Apicomplexan Parasite Diseases.	causal interaction,unassigned	3,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28142217&form=6&db=m	The cyclase-associated protein FgCap1 has both protein kinase A-dependent and -independent functions during deoxynivalenol production and plant infection in Fusarium graminearum.	causal interaction,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30446225&form=6&db=m	Syk and JNK signaling pathways are involved in inflammasome activation in macrophages infected with Streptococcus pneumoniae.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,4,1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31160822&form=6&db=m	An expanded subfamily of G-protein-coupled receptor genes in Fusarium graminearum required for wheat infection.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31363036&form=6&db=m	Hepatitis C Virus Infection Induces Hepatic Expression of NF-?B-Inducing Kinase and Lipogenesis by Downregulating miR-122.	causal interaction,unassigned	2,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089626&form=6&db=m	A putative PKA phosphorylation site S227 in MoSom1 is essential for infection-related morphogenesis and pathogenicity in Magnaporthe oryzae.	therapeutic application,unassigned	1,0	
2.7.11.11	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34101889&form=6&db=m	Oxidant activated soluble adenylate cyclase of Leishmania donovani regulates the cAMP-PKA signaling axis for its intra-macrophage survival during infection.	unassigned	-	
2.7.11.11	Infertility	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001908&form=6&db=m	Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.	causal interaction,unassigned	2,0	
2.7.11.11	Infertility	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33752482&form=6&db=m	Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,3,4,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822014&form=6&db=m	Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,3,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2999137&form=6&db=m	Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis.	ongoing research,unassigned	3,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9335553&form=6&db=m	Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047061&form=6&db=m	Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221061&form=6&db=m	Cilostazol ameliorates metabolic abnormalities with suppression of proinflammatory markers in a db/db mouse model of type 2 diabetes via activation of peroxisome proliferator-activated receptor gamma transcription.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25237037&form=6&db=m	Insulin resistance in Alzheimer's disease.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25645581&form=6&db=m	Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD.	causal interaction,unassigned	1,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26475209&form=6&db=m	Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.	causal interaction,ongoing research,unassigned	3,3,0	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28924165&form=6&db=m	MANF regulates hypothalamic control of food intake and body weight.	unassigned	-	
2.7.11.11	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30296358&form=6&db=m	Gingerenone A sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase.	causal interaction,unassigned	3,0	
2.7.11.11	Insulinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19376132&form=6&db=m	Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic beta-Cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Intellectual Disability	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31232219&form=6&db=m	Aminoglycoside drugs induce efficient read-through of CDKL5 nonsense mutations, slightly restoring its kinase activity.	causal interaction,unassigned	3,0	
2.7.11.11	Intellectual Disability	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33833410&form=6&db=m	Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.	ongoing research,unassigned	2,0	
2.7.11.11	Intestinal Volvulus	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7810028&form=6&db=m	Phosphoprotein patterns in Onchocerca volvulus developmental stages.	ongoing research,unassigned	3,0	
2.7.11.11	Intestinal Volvulus	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706794&form=6&db=m	Isolation and characterization of the regulatory subunit of cAMP-dependent protein kinase from the filarial parasite Onchocerca volvulus.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Intestinal Volvulus	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199697&form=6&db=m	Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.	diagnostic usage,unassigned	3,0	
2.7.11.11	Irritable Bowel Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949803&form=6&db=m	Aquaporins 1, 3 and 8 expression and cytokines in irritable bowel syndrome rats' colon via cAMP-PKA pathway.	unassigned	-	
2.7.11.11	Ischemic Attack, Transient	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383351&form=6&db=m	Changes of [3H]cyclic adenosine monophosphate binding in the gerbil brain following transient cerebral ischemia: an autoradiographic study and investigation of the effects of vinconate and pentobarbital.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Ischemic Attack, Transient	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383573&form=6&db=m	Sequential alterations of [3H]rolipram and [3H]cyclic adenosine monophosphate binding in the gerbil brain following transient cerebral ischemia.	ongoing research,therapeutic application,unassigned	1,1,0	
2.7.11.11	Kidney Failure, Chronic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30062489&form=6&db=m	Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.	therapeutic application,unassigned	1,0	
2.7.11.11	Kidney Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151618&form=6&db=m	Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,2,1	
2.7.11.11	Kidney Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789858&form=6&db=m	Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,2,4	
2.7.11.11	Kidney Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512660&form=6&db=m	Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles.	diagnostic usage,therapeutic application,unassigned	3,4,0	
2.7.11.11	Legionnaires' Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9614079&form=6&db=m	Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues.	therapeutic application,unassigned	3,0	
2.7.11.11	Leiomyoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19179429&form=6&db=m	Human uterine smooth muscle and leiomyoma cells differ in their rapid 17beta-estradiol signaling: implications for proliferation.	causal interaction,unassigned	1,0	
2.7.11.11	Lentigo	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027596&form=6&db=m	Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.	causal interaction,unassigned	4,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2000408&form=6&db=m	Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2337896&form=6&db=m	Circumvention of multidrug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,4,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834235&form=6&db=m	Cooperative interactions of protein kinase C and cAMP-dependent protein kinase systems in human promyelocytic leukemia HL60 cells.	ongoing research,unassigned	3,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3475067&form=6&db=m	Protein kinase C phosphorylates leukemia RNA polymerase II.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535055&form=6&db=m	Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells.	unassigned	-	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7915840&form=6&db=m	Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7947390&form=6&db=m	Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.	causal interaction,diagnostic usage,ongoing research,unassigned	4,3,4,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383802&form=6&db=m	Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities.	causal interaction,unassigned	1,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8449943&form=6&db=m	8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508278&form=6&db=m	Ligand-induced phosphorylation of anaphylatoxin receptors C3aR and C5aR is mediated by "G protein-coupled receptor kinases.	unassigned	-	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15741175&form=6&db=m	Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16305488&form=6&db=m	Targeting the kinase activity of the BCR-ABL fusion protein in patients with chronic myeloid leukemia.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,1,3,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20425431&form=6&db=m	Update on developmental therapeutics for acute lymphoblastic leukemia.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071472&form=6&db=m	Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23455313&form=6&db=m	Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.	causal interaction,ongoing research,unassigned	4,4,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27630163&form=6&db=m	Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II.	diagnostic usage,unassigned	1,0	
2.7.11.11	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34038722&form=6&db=m	Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection.	unassigned	-	
2.7.11.11	Leukemia, Erythroblastic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1644803&form=6&db=m	Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes.	causal interaction,ongoing research,unassigned	2,3,0	
2.7.11.11	Leukemia, Erythroblastic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830963&form=6&db=m	Protein kinase activity, growth and differentiation of murine erythroleukemia cells.	ongoing research,unassigned	4,0	
2.7.11.11	Leukemia, Erythroblastic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7721832&form=6&db=m	cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation.	causal interaction,unassigned	1,0	
2.7.11.11	Leukemia, Erythroblastic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8034608&form=6&db=m	Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation.	causal interaction,unassigned	3,0	
2.7.11.11	Leukemia, Erythroblastic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8376386&form=6&db=m	Impaired erythroid-specific gene expression in cAMP-dependent protein kinase-deficient murine erythroleukemia cells.	ongoing research,unassigned	1,0	
2.7.11.11	Leukemia, Erythroblastic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10799565&form=6&db=m	Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation	causal interaction,unassigned	3,0	
2.7.11.11	Leukemia, Erythroblastic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11521190&form=6&db=m	NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Leukemia, Lymphocytic, Chronic, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11468183&form=6&db=m	p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Leukemia, Lymphocytic, Chronic, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352795&form=6&db=m	Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497876&form=6&db=m	New assignments for multitasking signal transduction inhibitors.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17387035&form=6&db=m	Cancer drug resistance: the central role of the karyotype.	causal interaction,unassigned	4,0	
2.7.11.11	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625707&form=6&db=m	Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib.	causal interaction,diagnostic usage,unassigned	3,3,0	
2.7.11.11	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21091633&form=6&db=m	The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukemia and significantly increases the efficacy of nilotinib.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26379451&form=6&db=m	Cytomegalovirus-induced Hemorrhagic Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) on Dasatinib as an Upfront Therapy.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,4,0	
2.7.11.11	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27824120&form=6&db=m	Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,3,4	
2.7.11.11	Leukemia, Myeloid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1648978&form=6&db=m	Regulation of jun-B expression by a cyclic AMP (cAMP)-dependent mechanism in human myeloid cells.	causal interaction,unassigned	4,0	
2.7.11.11	Leukemia, Myeloid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7509793&form=6&db=m	Retinoylation of vimentin in the human myeloid leukemia cell line HL60.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Leukemia, Myeloid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8387020&form=6&db=m	Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells.	diagnostic usage,ongoing research,unassigned	3,3,0	
2.7.11.11	Leukemia, Myeloid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8416804&form=6&db=m	Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis.	causal interaction,unassigned	2,0	
2.7.11.11	Leukemia, Myeloid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11469804&form=6&db=m	Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22934770&form=6&db=m	State of the art of the therapeutic perspective of Sorafenib against hematological malignancies.	causal interaction,therapeutic application,unassigned	1,2,0	
2.7.11.11	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071472&form=6&db=m	Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25068104&form=6&db=m	An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes.	ongoing research,therapeutic application,unassigned	3,2,0	
2.7.11.11	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034990&form=6&db=m	Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,4,4	
2.7.11.11	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30679386&form=6&db=m	A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia.	therapeutic application,unassigned	4,0	
2.7.11.11	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30899434&form=6&db=m	Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Leukemia, Promyelocytic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535055&form=6&db=m	Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells.	unassigned	-	
2.7.11.11	Leukemia, Promyelocytic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7915840&form=6&db=m	Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Leukemia, Promyelocytic, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23455313&form=6&db=m	Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.	causal interaction,ongoing research,unassigned	4,4,0	
2.7.11.11	Leukemia, T-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16448540&form=6&db=m	ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.	causal interaction,unassigned	1,0	
2.7.11.11	Leukemia-Lymphoma, Adult T-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20180813&form=6&db=m	Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cells in vitro.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Lipodystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409151&form=6&db=m	Genetic basis of lipodystrophies and management of metabolic complications.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Liver Cirrhosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513687&form=6&db=m	Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Liver Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22290937&form=6&db=m	Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Liver Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900113&form=6&db=m	New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Liver Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26482853&form=6&db=m	A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,4,0	
2.7.11.11	Liver Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28304380&form=6&db=m	Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.	therapeutic application,unassigned	1,0	
2.7.11.11	Liver Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512660&form=6&db=m	Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles.	diagnostic usage,therapeutic application,unassigned	3,4,0	
2.7.11.11	Liver Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30226440&form=6&db=m	c-Myc is a major determinant for antitumor activity of Aurora A kinase inhibitor MLN8237 in thyroid cancer.	causal interaction,therapeutic application,unassigned	1,2,0	
2.7.11.11	Liver Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445947&form=6&db=m	Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery.	therapeutic application,unassigned	4,0	
2.7.11.11	Lordosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256992&form=6&db=m	Differential effect of kinase A and C blockers on lordosis facilitation by progesterone and its metabolites in ovariectomized estrogen-primed rats.	therapeutic application,unassigned	2,0	
2.7.11.11	Lordosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384517&form=6&db=m	In the ventral tegmental area, progestins' membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Lordosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18342351&form=6&db=m	Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.	therapeutic application,unassigned	3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6477548&form=6&db=m	Selective activation of cyclic AMP dependent protein kinase by calcitonin in a calcitonin secreting lung cancer cell line.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555286&form=6&db=m	[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,1	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18347185&form=6&db=m	Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,2,2,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728656&form=6&db=m	Role of LKB1 in lung cancer development.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19771275&form=6&db=m	AKAP12alpha is Associated with Promoter Methylation in Lung Cancer.	diagnostic usage,ongoing research,therapeutic application,unassigned	2,3,1,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21214998&form=6&db=m	[Experimental study of effects of nm23-H1 gene transfection on the change of PKA activity in human high-metastasis large cell lung cancer cell line L9981.]	diagnostic usage,ongoing research,therapeutic application,unassigned	3,4,1,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22488173&form=6&db=m	Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,4,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22954688&form=6&db=m	cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells.	causal interaction,unassigned	3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533274&form=6&db=m	TPL2 kinase is a suppressor of lung carcinogenesis.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756365&form=6&db=m	Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies.	diagnostic usage,therapeutic application,unassigned	2,3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24825907&form=6&db=m	Transcriptional regulation of oncogenic protein kinase C? (PKC?) by STAT1 and Sp1 proteins.	causal interaction,unassigned	4,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25530832&form=6&db=m	Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629323&form=6&db=m	JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,3	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27780853&form=6&db=m	The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27932759&form=6&db=m	[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].	diagnostic usage,ongoing research,unassigned	2,3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594000&form=6&db=m	Synthesis and preliminary PET imaging of (11)C and (18)F isotopologues of the ROS1/ALK inhibitor lorlatinib.	therapeutic application,unassigned	4,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29493460&form=6&db=m	Molecular Modeling, Docking, Dynamics and simulation of Gefitinib and its derivatives with EGFR in Non-Small Cell Lung Cancer.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30100047&form=6&db=m	[Medical treatment of small cell lung cancer: Can we leave the area of cisplatin-etoposide?]	therapeutic application,unassigned	2,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31160567&form=6&db=m	Activation of Aurora A kinase increases YAP stability via blockage of autophagy.	causal interaction,unassigned	3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32318301&form=6&db=m	Deep and Prolonged Response to Aurora A Kinase Inhibitor and Subsequently to Nivolumab in MYCL1-Driven Small-Cell Lung Cancer: Case Report and Literature Review.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,1,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32478891&form=6&db=m	Clinical and molecular characteristics of Chinese non-small cell lung cancer patients with ERBB2 transmembrane domain mutations.	causal interaction,diagnostic usage,ongoing research,unassigned	3,4,2,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32792859&form=6&db=m	Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation.	ongoing research,therapeutic application,unassigned	2,4,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33185028&form=6&db=m	Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: Exposure-Response Analyses of Pivotal ALTA Study.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,1,3,0	
2.7.11.11	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34009981&form=6&db=m	Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.	unassigned	-	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040283&form=6&db=m	Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.	unassigned	-	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8805675&form=6&db=m	Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228048&form=6&db=m	Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.	diagnostic usage,unassigned	1,0	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403274&form=6&db=m	High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.	causal interaction,diagnostic usage,unassigned	4,3,0	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10946316&form=6&db=m	Association of deficient type II protein kinase A activity with aberrant nuclear translocation of the RII beta subunit in systemic lupus erythematosus T lymphocytes.	diagnostic usage,unassigned	1,0	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11058571&form=6&db=m	mRNA mutations of type I protein kinase A regulatory subunit alpha in T lymphocytes of a subject with systemic lupus erythematosus.	unassigned	-	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11390516&form=6&db=m	Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Lupus Erythematosus, Systemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178799&form=6&db=m	Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Lymphatic Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832094&form=6&db=m	Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=174091&form=6&db=m	A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells.	ongoing research,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=191196&form=6&db=m	Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=191831&form=6&db=m	Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=193571&form=6&db=m	Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.	ongoing research,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=215323&form=6&db=m	Kinase-negative mutants of S49 mouse lymphoma cells carry a trans-dominant mutation affecting expression of cAMP-dependent protein kinase.	ongoing research,unassigned	2,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=219362&form=6&db=m	Mouse lymphoma cells with mutations of cyclic AMP-dependent protein kinase.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=226556&form=6&db=m	A variant of S49 mouse lymphoma cells with enhanced secretion of cyclic AMP.	ongoing research,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1310152&form=6&db=m	Linked spontaneous CG----TA mutations at CpG sites in the gene for protein kinase regulatory subunit.	unassigned	-	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1703630&form=6&db=m	A kinase-negative mutant of S49 mouse lymphoma cells is defective in posttranslational maturation of catalytic subunit of cyclic AMP-dependent protein kinase.	ongoing research,unassigned	2,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1846638&form=6&db=m	Analysis of the dominance of mutations in cAMP-binding sites of murine type I cAMP-dependent protein kinase in activation of kinase from heterozygous mutant lymphoma cells.	causal interaction,ongoing research,unassigned	2,3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847378&form=6&db=m	Mutations that alter the charge of type I regulatory subunit and modify activation properties of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2303438&form=6&db=m	The S49 Kin- cell line transcribes and translates a functional mRNA coding for the catalytic subunit of cAMP-dependent protein kinase.	unassigned	-	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2538415&form=6&db=m	Cholera toxin induces cAMP-independent degradation of Gs.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,1,1	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2545497&form=6&db=m	Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.	unassigned	-	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2628744&form=6&db=m	Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in murine T-lymphoma cells.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823395&form=6&db=m	Cyclic AMP-resistant mutants of S49 mouse lymphoma cells hemizygous for expression of regulatory subunit of type I cyclic AMP-dependent protein kinase.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830619&form=6&db=m	Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.	therapeutic application,unassigned	3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2843012&form=6&db=m	The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.	causal interaction,ongoing research,unassigned	3,4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2871555&form=6&db=m	Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.	ongoing research,unassigned	2,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2997237&form=6&db=m	Interactions between cyclic AMP- and phorbol ester-dependent phosphorylation systems in S49 mouse lymphoma cells.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000002&form=6&db=m	Hotspots for spontaneous and mutagen-induced lesions in regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3029091&form=6&db=m	Activation of type I cyclic AMP-dependent protein kinases with defective cyclic AMP-binding sites.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3029147&form=6&db=m	Phosphorylation of regulatory subunit of type I cyclic AMP-dependent protein kinase: biphasic effects of cyclic AMP in intact S49 mouse lymphoma cells.	ongoing research,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3157448&form=6&db=m	Phorbol ester-mediated protein phosphorylations in S49 mouse lymphoma cells.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6093701&form=6&db=m	Homology between regulatory subunits of type 1 cyclic AMP-dependent protein kinases from bovine and murine cells.	ongoing research,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6270127&form=6&db=m	Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP.	ongoing research,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6270151&form=6&db=m	Studies on the phosphorylation and synthesis of type I regulatory subunit of cyclic AMP-dependent protein kinase in intact S49 mouse lymphoma cells.	ongoing research,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6311840&form=6&db=m	Sites of phosphorylation and mutation in regulatory subunit of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells: mapping to structural domains.	ongoing research,unassigned	3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6627398&form=6&db=m	Revertants of a trans-dominant S49 mouse lymphoma mutant that affects expression of cAMP-dependent protein kinase.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6738532&form=6&db=m	Fine-structure mapping of charge-shift mutations in regulatory subunit of type I cyclic AMP-dependent protein kinase.	ongoing research,unassigned	2,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7593216&form=6&db=m	Second-site mutations in cyclic AMP-sensitive revertants of a Ka mutant of S49 mouse lymphoma cells reduce the affinity of regulatory subunit of cyclic AMP-dependent protein kinase for catalytic subunit.	unassigned	-	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7974005&form=6&db=m	Spectrum of spontaneous missense mutations causing cyclic AMP-resistance phenotypes in cultured S49 mouse lymphoma cells differs markedly from those of mutations induced by alkylating mutagens.	ongoing research,unassigned	1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663257&form=6&db=m	Pathways for degradation of the catalytic subunit of cAMP-dependent protein kinase differ in wild-type and kinase-negative S49 mouse lymphoma cells.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11962723&form=6&db=m	HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism.	therapeutic application,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18048352&form=6&db=m	Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells.	ongoing research,unassigned	3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24043741&form=6&db=m	Phase II Study of Alisertib, a Selective Aurora A Kinase Inhibitor, in Relapsed and Refractory Aggressive B- and T-Cell Non-Hodgkin Lymphomas.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24106904&form=6&db=m	Signaling pathways in lymphoma: pathogenesis and therapeutic targets.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24468319&form=6&db=m	Management of relapses after hematopoietic cell transplantation in T-cell non-Hodgkin lymphomas.	therapeutic application,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26077240&form=6&db=m	Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084989&form=6&db=m	Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose.	diagnostic usage,ongoing research,therapeutic application,unassigned	2,3,3,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594000&form=6&db=m	Synthesis and preliminary PET imaging of (11)C and (18)F isotopologues of the ROS1/ALK inhibitor lorlatinib.	therapeutic application,unassigned	4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30985952&form=6&db=m	Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31429028&form=6&db=m	Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma.	ongoing research,therapeutic application,unassigned	3,4,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534006&form=6&db=m	Cutting Edge: ROR1/CD19 Receptor Complex Promotes Growth of Mantle Cell Lymphoma Cells Independently of the B Cell Receptor-BTK Signaling Pathway.	causal interaction,therapeutic application,unassigned	1,2,0	
2.7.11.11	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33185028&form=6&db=m	Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: Exposure-Response Analyses of Pivotal ALTA Study.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,1,3,0	
2.7.11.11	Lymphoma, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8730099&form=6&db=m	Role of cyclin A and p27 in anti-IgM induced G1 growth arrest of murine B-cell lymphomas.	unassigned	-	
2.7.11.11	Lymphoma, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082475&form=6&db=m	Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/vincristine in Relapsed/refractory Aggressive B-cell Lymphoma.	ongoing research,therapeutic application,unassigned	2,2,0	
2.7.11.11	Lymphoma, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33488968&form=6&db=m	Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Lymphoma, Large B-Cell, Diffuse	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33488968&form=6&db=m	Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Lymphoma, Mantle-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534006&form=6&db=m	Cutting Edge: ROR1/CD19 Receptor Complex Promotes Growth of Mantle Cell Lymphoma Cells Independently of the B Cell Receptor-BTK Signaling Pathway.	causal interaction,therapeutic application,unassigned	1,2,0	
2.7.11.11	Lymphoma, Non-Hodgkin	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7824924&form=6&db=m	Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Lymphoma, Non-Hodgkin	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8122112&form=6&db=m	Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Lymphoma, Non-Hodgkin	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352795&form=6&db=m	Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Lymphoma, Non-Hodgkin	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082475&form=6&db=m	Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/vincristine in Relapsed/refractory Aggressive B-cell Lymphoma.	ongoing research,therapeutic application,unassigned	2,2,0	
2.7.11.11	Lymphoma, T-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3352600&form=6&db=m	Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).	therapeutic application,unassigned	1,0	
2.7.11.11	Lymphoma, T-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25878331&form=6&db=m	Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma.	causal interaction,therapeutic application,unassigned	2,4,0	
2.7.11.11	Lymphoma, T-Cell, Peripheral	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30707661&form=6&db=m	Randomized Phase III Study of Alisertib or Investigator's Choice (Selected Single Agent) in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma.	diagnostic usage,ongoing research,therapeutic application,unassigned	2,3,2,0	
2.7.11.11	Lymphoproliferative Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186254&form=6&db=m	The role of aurora A and polo-like kinases in high-risk lymphomas.	causal interaction,unassigned	3,0	
2.7.11.11	Malaria	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11559352&form=6&db=m	The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Malaria	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19159956&form=6&db=m	Expression and biochemical characterization of the Plasmodium falciparum protein kinase A catalytic subunit.	causal interaction,unassigned	4,0	
2.7.11.11	Malformations of Cortical Development, Group II	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11702948&form=6&db=m	zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly.	unassigned	-	
2.7.11.11	Malnutrition	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876914&form=6&db=m	Activity of cAMP-dependent protein kinase is reduced in protein-energy malnourished rats.	ongoing research,unassigned	1,0	
2.7.11.11	Mastocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2991742&form=6&db=m	Cyclic AMP, nuclear protein kinase and the PY815 cell cycle.	unassigned	-	
2.7.11.11	Mastocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6408911&form=6&db=m	Mammalian histidine decarboxylase: effect by protein kinase on mouse mastocytoma histidine decarboxylase.	ongoing research,therapeutic application,unassigned	1,1,0	
2.7.11.11	Measles	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26272026&form=6&db=m	Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy.	therapeutic application,unassigned	2,0	
2.7.11.11	Medulloblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21652733&form=6&db=m	A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110{gamma} Isoform in Medulloblastoma Cell Proliferation and Chemoresistance.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17836&form=6&db=m	Activation of melanoma tyrosinase by a cyclic AMP-dependent protein kinase in a cell-free system.	unassigned	-	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=207755&form=6&db=m	Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.	diagnostic usage,unassigned	3,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=220273&form=6&db=m	Evidence suggesting that a cyclic AMP-dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells.	causal interaction,unassigned	1,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2392322&form=6&db=m	Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834040&form=6&db=m	Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture.	ongoing research,unassigned	3,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011473&form=6&db=m	The effect of retinoic acid on protein phosphorylation in mouse melanoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,2,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6248511&form=6&db=m	Retinoic acid increases cyclic AMP-dependent protein kinase activity in murine melanoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,3,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6251806&form=6&db=m	Suppression of cyclic AMP-dependent protein kinase activity in murine melanoma cells by 12-0-tetradecanoylphorbol-13-acetate.	ongoing research,unassigned	4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117614&form=6&db=m	Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9447965&form=6&db=m	Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.	ongoing research,unassigned	1,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9770355&form=6&db=m	Activation of cAMP-dependent protein kinase is required for optimal alpha-melanocyte-stimulating hormone-induced pigmentation.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616526&form=6&db=m	Human melanoma TrkC: its association with a purine-analog-sensitive kinase activity.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142677&form=6&db=m	Extracellular cAMP-dependent protein kinase (ECPKA) in melanoma.	causal interaction,diagnostic usage,unassigned	3,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16452469&form=6&db=m	Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells.	causal interaction,ongoing research,unassigned	4,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199087&form=6&db=m	Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21277992&form=6&db=m	Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and phosphatidylinositol 3-kinase pathways.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21745488&form=6&db=m	Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.	causal interaction,diagnostic usage,ongoing research,unassigned	3,3,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22537109&form=6&db=m	Identification of a novel family of BRAF(V???E) inhibitors.	therapeutic application,unassigned	2,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24336958&form=6&db=m	PP6C Hotspot Mutations in Melanoma Display Sensitivity to Aurora Kinase Inhibition.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25041062&form=6&db=m	Human papillomavirus evaluation of vemurafenib induced skin epithelial tumors: a case series.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26082174&form=6&db=m	Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway.	causal interaction,ongoing research,therapeutic application,unassigned	2,3,1,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27892929&form=6&db=m	A review of kinase fusions in melanocytic tumors.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273450&form=6&db=m	ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.	causal interaction,unassigned	4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30677858&form=6&db=m	Reaccion acneiforme noduloquistica secundaria a vemurafenib con buena respuesta a isotretinoina oralSevere acneiform eruption associated with vemurafenib with response to isotretinoin.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32696585&form=6&db=m	Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Melanoma, Experimental	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=207755&form=6&db=m	Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.	diagnostic usage,unassigned	3,0	
2.7.11.11	Melanoma, Experimental	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=220273&form=6&db=m	Evidence suggesting that a cyclic AMP-dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells.	causal interaction,unassigned	1,0	
2.7.11.11	Melanoma, Experimental	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9447965&form=6&db=m	Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.	ongoing research,unassigned	1,0	
2.7.11.11	Melanoma, Experimental	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22195035&form=6&db=m	LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.	causal interaction,therapeutic application,unassigned	2,2,0	
2.7.11.11	Memory Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3016598&form=6&db=m	Altered autophosphorylation of adenosine 3',5'-phosphate-dependent protein kinase in the dunce memory mutant of Drosophila melanogaster.	causal interaction,unassigned	4,0	
2.7.11.11	Meningitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26231374&form=6&db=m	The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis.	causal interaction,unassigned	2,0	
2.7.11.11	Mesothelioma, Malignant	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32608142&form=6&db=m	A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma.	ongoing research,unassigned	3,0	
2.7.11.11	Metrorrhagia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17947987&form=6&db=m	A membrane capture assay for lipid kinase activity.	diagnostic usage,unassigned	3,0	
2.7.11.11	Microcephaly	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17564965&form=6&db=m	Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling.	causal interaction,unassigned	1,0	
2.7.11.11	Mucocutaneous Lymph Node Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20616737&form=6&db=m	Kawasaki disease: update on pathogenesis.	causal interaction,unassigned	4,0	
2.7.11.11	Mucocutaneous Lymph Node Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23747857&form=6&db=m	PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation.	therapeutic application,unassigned	1,0	
2.7.11.11	Multiple Myeloma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297535&form=6&db=m	Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells.	unassigned	-	
2.7.11.11	Multiple Myeloma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352795&form=6&db=m	Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Multiple Myeloma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32978717&form=6&db=m	Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.	causal interaction,ongoing research,unassigned	4,2,0	
2.7.11.11	Multiple Myeloma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33971243&form=6&db=m	Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.	causal interaction,diagnostic usage,unassigned	3,3,0	
2.7.11.11	Murine Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24283208&form=6&db=m	The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,3,2,1	
2.7.11.11	Myasthenia Gravis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9000000&form=6&db=m	Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein.	diagnostic usage,unassigned	2,0	
2.7.11.11	Mycoses	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15597741&form=6&db=m	cAMP-pKA signaling regulates multiple steps of fungal infection cooperatively with Cmk1 MAP kinase in Colletotrichum lagenarium.	causal interaction,unassigned	3,0	
2.7.11.11	Myelodysplastic Syndromes	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25068104&form=6&db=m	An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes.	ongoing research,therapeutic application,unassigned	3,2,0	
2.7.11.11	Myeloproliferative Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390466&form=6&db=m	Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,2,1,0	
2.7.11.11	Myeloproliferative Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19521323&form=6&db=m	The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Myocardial Infarction	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6270907&form=6&db=m	[cAMP-dependent phosphorylation of myocardial troponin in experimental myocardial infarction]	diagnostic usage,unassigned	3,0	
2.7.11.11	Myocardial Infarction	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8762044&form=6&db=m	Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,2,3,0	
2.7.11.11	Myocardial Infarction	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24920296&form=6&db=m	RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.	causal interaction,unassigned	2,0	
2.7.11.11	Myocardial Infarction	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314868&form=6&db=m	microRNA-208a in an early stage myocardial infarction rat model and the effect on cAMP-PKA signaling pathway.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,3,0	
2.7.11.11	Myocardial Infarction	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33923648&form=6&db=m	Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction.	therapeutic application,unassigned	1,0	
2.7.11.11	Myocardial Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775438&form=6&db=m	Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.	unassigned	-	
2.7.11.11	Myocardial Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25008320&form=6&db=m	Structural Basis for Phosphorylation and Lysine Acetylation Cross-talk in a Kinase Motif Associated with Myocardial Ischemia and Cardioprotection.	causal interaction,unassigned	3,0	
2.7.11.11	Myocarditis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2968798&form=6&db=m	The increase in viscosity and peroxidation of sarcoplasmic reticulum membrane lipids in isadrine myocarditis.	unassigned	-	
2.7.11.11	Myocarditis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000039&form=6&db=m	[Effect of the catalytic subunit of cAMP-dependent protein kinase on the electrical activity of the rat heart in isadrine myocarditis]	ongoing research,unassigned	3,0	
2.7.11.11	Myotonic Dystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1307246&form=6&db=m	Unstable DNA may be responsible for the incomplete penetrance of the myotonic dystrophy phenotype.	unassigned	-	
2.7.11.11	Myotonic Dystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8617235&form=6&db=m	The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.	therapeutic application,unassigned	1,0	
2.7.11.11	Myotonic Dystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9092543&form=6&db=m	Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.	causal interaction,unassigned	3,0	
2.7.11.11	Myotonic Dystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12076668&form=6&db=m	Dominantly inherited, non-coding microsatellite expansion disorders.	causal interaction,unassigned	1,0	
2.7.11.11	Myotonic Dystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363905&form=6&db=m	Pathogenic RNA repeats: an expanding role in genetic disease.	causal interaction,unassigned	1,0	
2.7.11.11	Myotonic Dystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18724054&form=6&db=m	Dominant non-coding repeat expansions in human disease.	causal interaction,unassigned	3,0	
2.7.11.11	Myotonic Dystrophy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309729&form=6&db=m	Structure of dystrophia myotonica protein kinase.	unassigned	-	
2.7.11.11	Myxoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26130139&form=6&db=m	Carney complex: an update.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,2,2,0	
2.7.11.11	Myxoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498419&form=6&db=m	Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Myxoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28369983&form=6&db=m	Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.	causal interaction,diagnostic usage,unassigned	2,3,0	
2.7.11.11	Myxoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205368&form=6&db=m	Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.	causal interaction,unassigned	2,0	
2.7.11.11	Myxoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027596&form=6&db=m	Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075275&form=6&db=m	Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555286&form=6&db=m	[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,1	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16606541&form=6&db=m	[Screening of a sub-clone of human breast cancer cells with high metastasis potential]	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21277992&form=6&db=m	Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and phosphatidylinositol 3-kinase pathways.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23511482&form=6&db=m	PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24196587&form=6&db=m	Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.	unassigned	-	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24825907&form=6&db=m	Transcriptional regulation of oncogenic protein kinase C? (PKC?) by STAT1 and Sp1 proteins.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162504&form=6&db=m	Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.	therapeutic application,unassigned	4,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750740&form=6&db=m	Treatment of distant metastases from follicular cell-derived thyroid cancer.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27829215&form=6&db=m	RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27977010&form=6&db=m	TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.	causal interaction,diagnostic usage,unassigned	4,1,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270217&form=6&db=m	DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,4	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050279&form=6&db=m	SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts.	unassigned	-	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30374056&form=6&db=m	Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30444612&form=6&db=m	Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030797&form=6&db=m	GPER-regulated lncRNA-Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple-negative breast cancer.	causal interaction,ongoing research,unassigned	3,1,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468675&form=6&db=m	Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells.	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33556559&form=6&db=m	Reciprocal activation within a kinase effector complex: A mechanism for the persistence of molecular memory.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832094&form=6&db=m	Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=190257&form=6&db=m	Adenosine 3'5'-cyclic monophosphate dependent protein kinase in human adrenocortical tumors.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=195337&form=6&db=m	Dibutyryl cyclic AMP mimics ovariectomy: nuclear protein phosphorylation in mammary tumor regression.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=195724&form=6&db=m	Partial purification and characterization of the defective cyclic adenosine 3':5'-monophosphate binding protein kinase from adrenocortical carcinoma.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=202267&form=6&db=m	Protein phosphorylation in normal and neoplastic development. Cyclic AMP-dependent protein kinase activity in urethane-induced pulmonary tumours.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=207755&form=6&db=m	Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.	diagnostic usage,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=215599&form=6&db=m	Altered cyclic AMP-dependent protein kinase activity in a mutant adrenocortical tumor cell line.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=216364&form=6&db=m	Increase of cyclic AMP-dependent protein kinase type II as an early event in hormone-dependent mammary tumor regression.	causal interaction,therapeutic application,unassigned	4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=227734&form=6&db=m	Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors.	causal interaction,ongoing research,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1319722&form=6&db=m	Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytes.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1329084&form=6&db=m	Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.	diagnostic usage,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1333050&form=6&db=m	The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin-regulated adrenocortical functions.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1458192&form=6&db=m	[The inhibiting effect of 8-Cl-adenosine-3',5'-cyclophosphate on the growth of melanoma B-16 in mice]	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1567825&form=6&db=m	Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1646708&form=6&db=m	Alterations in the cAMP signal transduction pathway in mouse lung tumorigenesis.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1688548&form=6&db=m	8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1689049&form=6&db=m	An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693923&form=6&db=m	cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1818438&form=6&db=m	The in vitro effects of glycyrrhizin and the derivatives of glycyrrhetinic acid on the activity of cAMP-dependent protein kinase and phosphorylation of cellular polypeptide by the kinase from Ehrlich ascites tumor cells.	diagnostic usage,ongoing research,unassigned	3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1824683&form=6&db=m	Changes in cyclic adenosine monophosphate-responsive element binding proteins in rat hepatomas.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2000408&form=6&db=m	Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2157978&form=6&db=m	Reduced gonadotropin responses in a novel clonal strain of Leydig tumor cells established by transfection of MA-10 cells with a mutant gene of the type I regulatory subunit of the cAMP-dependent protein kinase.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159459&form=6&db=m	Decreased expression of the type I isozyme of cAMP-dependent protein kinase in tumor cell lines of lung epithelial origin.	causal interaction,ongoing research,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2433276&form=6&db=m	Phosphorylation of human lysosomal arylsulfatase B by cAMP-dependent protein kinase. Different sites of phosphorylation between normal and cancer tissues.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539602&form=6&db=m	Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546938&form=6&db=m	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547599&form=6&db=m	Recovery of responsiveness to ACTH and cAMP in a protein kinase-defective adrenal cell mutant following transfection with a protein kinase gene.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549382&form=6&db=m	Beta 2-adrenergic receptor regulation after transfection into a cell line deficient in the cAMP-dependent protein kinase.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2676146&form=6&db=m	Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2819108&form=6&db=m	[The effect of estradiol on the activity of cAMP-dependent protein kinase in cells of estradiol-dependent tumors of the rat mammary gland. The role of a thermally stable protein inhibitor of cAMP-dependent protein kinase]	diagnostic usage,ongoing research,therapeutic application,unassigned	2,4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820963&form=6&db=m	Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827663&form=6&db=m	Alterations of protein kinase isozymes in transplantable human lung cancer with special reference to the phosphorylation of arylsulfatase B.	causal interaction,diagnostic usage,ongoing research,unassigned	4,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2830966&form=6&db=m	Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849297&form=6&db=m	Characterization of the morphological, growth, and steroidogenic effect of TPA on mouse Y-1 adrenal cortical tumor cells in culture.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2883182&form=6&db=m	Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982578&form=6&db=m	Characterization of cell surface adenosine 3',5'-monophosphate-binding proteins in Y-1 mouse adrenal tumor cells.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988884&form=6&db=m	Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2993029&form=6&db=m	Membranal tyrosine protein kinase activity (but not cAMP-dependent protein kinase activity) is associated with growth of rat mammary tumors.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,3,4,2	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2994994&form=6&db=m	[Change in the protein kinase activity of glandular stomach mucosa in rats during malignant transformation]	causal interaction,diagnostic usage,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2999799&form=6&db=m	Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3002763&form=6&db=m	Phosphorylation of three proteins in the plasma membrane of Y-1 adrenal cells by a membrane-bound adenosine 3',5'-monophosphate-dependent protein kinase.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3003121&form=6&db=m	Recovery of hormonal regulation in protein kinase defective adrenal cells through DNA-mediated gene transfer.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3006676&form=6&db=m	Anticarcinogenic effect of retinoids on 7,12-dimethylbenz(a)anthracene-induced mammary tumor induction, and its relationship to cyclic AMP-dependent protein kinase.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009170&form=6&db=m	The roles of cAMP and cAMP-dependent protein kinase in forskolin's actions on Y1 adrenocortical tumor cells.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3017786&form=6&db=m	Cyclic AMP-dependent protein kinase-mediated desensitisation of adrenal tumour cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030365&form=6&db=m	The roles of cAMP and cAMP-dependent protein kinase in the regulation of adrenocortical functions: analysis using DNA-mediated gene transfer.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032409&form=6&db=m	Characterization of the cyclic adenosine 3':5'-monophosphate effector system in hormone-dependent and hormone-independent rat mammary carcinomas.	ongoing research,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032422&form=6&db=m	Differential effects of dibutyryl cyclic adenosine monophosphate and retinoic acid on the growth, differentiation, and cyclic adenosine monophosphate-binding protein of murine neuroblastoma cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032572&form=6&db=m	Ultrastructural localization of cyclic adenosine 3',5'-monophosphate-dependent protein kinase after adrenocorticotropin stimulation in adrenal cortical tumor cells.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3033199&form=6&db=m	Molecular mechanisms of corticotropin-releasing factor stimulation of calcium mobilization and adrenocorticotropin release from anterior pituitary tumor cells.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3157448&form=6&db=m	Phorbol ester-mediated protein phosphorylations in S49 mouse lymphoma cells.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3212670&form=6&db=m	Nuclear protein kinase substrates in AtT-20 cells: translocation of a 14 kDa phosphoprotein.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3384398&form=6&db=m	Protein phosphorylation of human lysosomal arylsulfatase B from normal and cancer tissues.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3568986&form=6&db=m	[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3624237&form=6&db=m	Properties of p19, a novel cAMP-dependent protein kinase substrate protein purified from bovine brain.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3689858&form=6&db=m	Cellular localization and age-dependent changes in mRNA for cyclic adenosine 3',5'-monophosphate-dependent protein kinases in rat testis.	causal interaction,diagnostic usage,ongoing research,unassigned	1,2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3697380&form=6&db=m	Characterization of protein tyrosine kinase activity in murine Leydig tumor cells.	diagnostic usage,ongoing research,unassigned	2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3778969&form=6&db=m	[Activation of protein kinase C and cAMP-dependent protein kinase in hormone-dependent mammary gland tumors during stimulation of their growth with progesterone and estrone]	causal interaction,ongoing research,therapeutic application,unassigned	3,3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3978625&form=6&db=m	Type I and II cyclic adenosine 3':5'-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas.	causal interaction,diagnostic usage,ongoing research,unassigned	4,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088035&form=6&db=m	Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6092042&form=6&db=m	Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase activity in rodent pituitary tissue: possible role in cAMP-dependent hormone secretion.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6248865&form=6&db=m	Regulation of ornithine decarboxylase activity by corticotropin in adrenocortical tumor cell clones: roles of cyclic AMP and cyclic AMP-dependent protein kinase.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6250347&form=6&db=m	Cyclic AMP-dependent protein kinase type I and type II and cyclic AMP binding in human mammary tumors.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6250407&form=6&db=m	Parathyroid hormone modulates protein kinase in giant cell tumors of human bone.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6254121&form=6&db=m	The relationship of the cyclic nucleotide system to inhibition of hepatic drug metabolism in Walker 256 carcinoma-bearing rats.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6256577&form=6&db=m	Regression of hormone-dependent mammary tumors in Sprague-Dawley rats as a result of tamoxifen or pharmacologic doses of 17 beta-estradiol: cyclic adenosine 3',5'-monophosphate-mediated events.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6271693&form=6&db=m	Activation of cyclic AMP-dependent protein kinase activity during LPS stimulation of macrophage tumor cell line, J774.1.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6294128&form=6&db=m	Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6299385&form=6&db=m	Cyclic AMP and tumor promoters cause differential induction of ornithine decarboxylase and accumulation of putrescine in Chinese hamster ovary cells deficient in cyclic AMP-dependent protein kinase.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6323187&form=6&db=m	cAMP-independent protein kinase activity is correlated with growth of rat mammary tumors.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6360384&form=6&db=m	Appearance of 50,000- and 52,000-dalton cAMP receptor proteins in the nucleoli of regressing MCF-7 human breast cancer upon estrogen withdrawal.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6465852&form=6&db=m	Correlation of estrogen receptors and charge alterations of regulatory subunits of cAMP-dependent protein kinases in human mammary tumor cells.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6593229&form=6&db=m	Enhanced casein kinase II activity in human tumour cell cultures.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6615513&form=6&db=m	Retinal inhibits TPA activated, calcium-dependent, phospholipid-dependent protein kinase ("C" kinase).	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6985349&form=6&db=m	cAMP-dependent protein kinase II interactions with nuclei derived from rat mammary tumor.	causal interaction,ongoing research,therapeutic application,unassigned	1,4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7214351&form=6&db=m	Cyclic adenosine 3':5-monophosphate receptor proteins in hormone-dependent and -independent rat mammary tumors.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7499445&form=6&db=m	Fructose 2,6-bisphosphate metabolism in Ehrlich ascites tumour cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7535935&form=6&db=m	Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells.	causal interaction,ongoing research,unassigned	2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585118&form=6&db=m	A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7734767&form=6&db=m	[Discovery of a new gene frequently inactivated in human cancers: protein p16, a cell cycle regulator]	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981127&form=6&db=m	Biochemical parameters in the anterior pituitary during the course of tumorigenesis induced by diethylstilbestrol treatment.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022860&form=6&db=m	The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related diseases.	diagnostic usage,therapeutic application,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8402589&form=6&db=m	Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.	causal interaction,diagnostic usage,ongoing research,unassigned	4,3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8428367&form=6&db=m	An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.	causal interaction,ongoing research,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8790599&form=6&db=m	Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8796872&form=6&db=m	Traditional Chinese medicine yields a kinase inhibitor for use in cancer and HIV.	therapeutic application,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8915509&form=6&db=m	Protein kinase A-directed antisense restrains cancer growth: sequence-specific inhibition of gene expression.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8986790&form=6&db=m	Cyclin E, a redundant cyclin in breast cancer.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9010913&form=6&db=m	Antisense DNA toward type I protein kinase A produces sustained inhibition of tumor growth.	causal interaction,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9136078&form=6&db=m	Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m	Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9268374&form=6&db=m	Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349751&form=6&db=m	The cellular mechanisms of corticotropin-releasing hormone (CRH)-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH.	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464489&form=6&db=m	Release of lipoprotein lipase from Ehrlich ascites tumor produced by an association with a rapid increase in cyclic AMP content.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9563874&form=6&db=m	Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.	causal interaction,diagnostic usage,ongoing research,unassigned	4,1,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9623882&form=6&db=m	Cisplatin resistance in cyclic AMP-dependent protein kinase mutants.	causal interaction,ongoing research,therapeutic application,unassigned	2,4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696392&form=6&db=m	Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726636&form=6&db=m	Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815703&form=6&db=m	8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer.	causal interaction,ongoing research,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815886&form=6&db=m	Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815969&form=6&db=m	Cooperative antiproliferative effects of 8-chloro-cyclic AMP and 528 anti-epidermal growth factor receptor monoclonal antibody on human cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070893&form=6&db=m	Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer.	causal interaction,diagnostic usage,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213224&form=6&db=m	Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10395066&form=6&db=m	Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446459&form=6&db=m	Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10490835&form=6&db=m	Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10570186&form=6&db=m	Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10577386&form=6&db=m	Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10642527&form=6&db=m	LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10653609&form=6&db=m	Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.	causal interaction,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10699953&form=6&db=m	Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A.	causal interaction,ongoing research,unassigned	3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10759715&form=6&db=m	Constitutive levels of cAMP-dependent protein kinase activity determine sensitivity of human multidrug-resistant leukaemic cell lines to growth inhibition and apoptosis by forskolin and tumour necrosis factor alpha.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778949&form=6&db=m	A safety and pharmacokinetic study of a mixed-backbone oligonucleotide (GEM231) targeting the type I protein kinase A by two-hour infusions in patients with refractory solid tumors.	causal interaction,ongoing research,therapeutic application,unassigned	2,2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10999726&form=6&db=m	Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095968&form=6&db=m	Biochemical characterization of extracellular cAMP-dependent protein kinase as a tumor marker.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11106252&form=6&db=m	Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,3	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297520&form=6&db=m	Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11724348&form=6&db=m	Role of MAP kinase pathways in primitive neuroectodermal tumors.	causal interaction,diagnostic usage,ongoing research,unassigned	4,1,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12057025&form=6&db=m	Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063552&form=6&db=m	Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12080384&form=6&db=m	Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12119265&form=6&db=m	Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12119273&form=6&db=m	Protein kinase A as target for novel integrated strategies of cancer therapy.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203783&form=6&db=m	Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,2,1	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237321&form=6&db=m	Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12453888&form=6&db=m	Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631623&form=6&db=m	Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12666684&form=6&db=m	Clinical and molecular genetics of Carney complex.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727920&form=6&db=m	Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12759366&form=6&db=m	Adjacent sequence controls the response polarity of nitric oxide-sensitive Sp factor binding sites.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941541&form=6&db=m	Decreased adenylyl cyclase and cAMP-dependent protein kinase activities inhibit the cytotoxic function of human natural killer cells.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751840&form=6&db=m	Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,3,1	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766760&form=6&db=m	JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells.	causal interaction,therapeutic application,unassigned	4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142677&form=6&db=m	Extracellular cAMP-dependent protein kinase (ECPKA) in melanoma.	causal interaction,diagnostic usage,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240549&form=6&db=m	Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15258463&form=6&db=m	The viral death effector Apoptin reveals tumor-specific processes.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15496411&form=6&db=m	Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15525605&form=6&db=m	cAMP-dependent protein kinase activation inhibits proliferation and enhances apoptotic effect of tumor necrosis factor-alpha in NCI-H295R adrenocortical cells.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555286&form=6&db=m	[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,1	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15591278&form=6&db=m	A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604237&form=6&db=m	Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681023&form=6&db=m	AMPK, the metabolic syndrome and cancer.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15733742&form=6&db=m	AMP-activated protein kinase: balancing the scales.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15777610&form=6&db=m	Rolipram, salbutamol and prostaglandin E2 suppress TNFalpha release from human monocytes by activating Type II cAMP-dependent protein kinase.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15805292&form=6&db=m	RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15905176&form=6&db=m	Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16107724&form=6&db=m	A dominant interfering Bub1 mutant is insufficient to induce or alter thymic tumorigenesis in vivo, even in a sensitized genetic background.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16109713&form=6&db=m	Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115938&form=6&db=m	CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,3,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16171564&form=6&db=m	Apoptin acts as a tumor-specific killer: potentials for an anti-tumor therapy.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204369&form=6&db=m	Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas.	causal interaction,diagnostic usage,ongoing research,unassigned	1,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16288019&form=6&db=m	Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371346&form=6&db=m	Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394142&form=6&db=m	Chemoprevention with Protein Kinase A RI{alpha} Antisense in DMBA-Mammary Carcinogenesis.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16438946&form=6&db=m	Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: Involvement of cAMP-PKA and MAPK pathways.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516931&form=6&db=m	Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid.	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16606541&form=6&db=m	[Screening of a sub-clone of human breast cancer cells with high metastasis potential]	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16705314&form=6&db=m	Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835227&form=6&db=m	Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16862152&form=6&db=m	Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16866191&form=6&db=m	Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16873055&form=6&db=m	CK2 and PML: regulating the regulator.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16932252&form=6&db=m	Drug insight: Small-molecule inhibitors of protein kinases in the treatment of thyroid cancer.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16947083&form=6&db=m	The ErbB2 Signaling Network as a Target for Breast Cancer Therapy.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982736&form=6&db=m	Autoantibody cancer biomarker: extracellular protein kinase a.	causal interaction,diagnostic usage,ongoing research,unassigned	2,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214372&form=6&db=m	Diagnostic relevance of overexpressed NOK mRNA in breast cancer.	ongoing research,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237275&form=6&db=m	Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308110&form=6&db=m	Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17353197&form=6&db=m	Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17360485&form=6&db=m	Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17416772&form=6&db=m	Extracellular activity of cyclic AMP-dependent protein kinase as a biomarker for human cancer detection: distribution characteristics in a normal population and cancer patients.	diagnostic usage,ongoing research,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17463247&form=6&db=m	Revisiting the role of the mother centriole in centriole biogenesis.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545617&form=6&db=m	Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.	causal interaction,ongoing research,therapeutic application,unassigned	3,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17577780&form=6&db=m	Gravin gene expression in acute leukaemias: clinical importance and review of the literature.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17878409&form=6&db=m	Dialogue between LKB1 and AMPK: a hot topic at the cellular pole.	causal interaction,therapeutic application,unassigned	1,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17935280&form=6&db=m	Aurora-A kinase regulates NF-kB activity: lessons from combination studies.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17989356&form=6&db=m	Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17993511&form=6&db=m	Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18060853&form=6&db=m	Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I.	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199717&form=6&db=m	Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18245477&form=6&db=m	Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis.	diagnostic usage,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301454&form=6&db=m	Pleural mesothelioma: diagnostic problems and evaluation of prognostic factors.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18406106&form=6&db=m	EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase.	causal interaction,ongoing research,unassigned	3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18451138&form=6&db=m	Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18469513&form=6&db=m	Understanding how kinase-targeted therapies work.	therapeutic application,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18497064&form=6&db=m	Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18670641&form=6&db=m	Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18949061&form=6&db=m	Anticancer therapy: boosting the bang of Bim.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029992&form=6&db=m	Protective vascular and myocardial effects of adiponectin.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19111595&form=6&db=m	The differential regulation of steroidogenic acute regulatory protein-mediated steroidogenesis by type I and type II PKA in MA-10 cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221050&form=6&db=m	IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19442041&form=6&db=m	Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470739&form=6&db=m	Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision.	ongoing research,therapeutic application,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19490892&form=6&db=m	Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19738044&form=6&db=m	Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19746225&form=6&db=m	Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20196102&form=6&db=m	Biology of Aurora A kinase: Implications in cancer manifestation and therapy.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197380&form=6&db=m	MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199087&form=6&db=m	Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199697&form=6&db=m	Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.	diagnostic usage,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227403&form=6&db=m	Rapid determination of AKAP12 promoter methylation levels in peripheral blood using methylation-sensitive high resolution melting (MS-HRM) analysis: application in colorectal cancer.	diagnostic usage,ongoing research,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20387822&form=6&db=m	Characterization of surfaces presenting covalently immobilized oligopeptides using near-edge X-ray absorption fine structure spectroscopy.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498073&form=6&db=m	The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20607239&form=6&db=m	Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20705954&form=6&db=m	Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20724522&form=6&db=m	Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: safety, pharmacokinetics, and pharmacodynamics.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837665&form=6&db=m	Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20838604&form=6&db=m	Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20940146&form=6&db=m	Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951342&form=6&db=m	The hippo signaling pathway in development and cancer.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20979053&form=6&db=m	Down-regulation of tumor suppressor a kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21041411&form=6&db=m	Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042281&form=6&db=m	Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111774&form=6&db=m	How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21148750&form=6&db=m	Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21346175&form=6&db=m	Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21497122&form=6&db=m	Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21498571&form=6&db=m	A kinase shRNA screen links LATS2 and the pRB tumor suppressor.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21536687&form=6&db=m	High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556497&form=6&db=m	Antitumoral activity of flavone L-86-8275.	ongoing research,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788394&form=6&db=m	A Novel Cell-Based, High-Content Assay for Phosphorylation of Lats2 by Aurora A.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21852354&form=6&db=m	Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21960225&form=6&db=m	Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays.	causal interaction,therapeutic application,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22052684&form=6&db=m	Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22174290&form=6&db=m	A kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22210404&form=6&db=m	Involvement of IGF-I signaling pathway in the regulation of steroidogenesis in mouse Leydig cells treated with fenvalerate.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22303466&form=6&db=m	Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22396649&form=6&db=m	Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22500798&form=6&db=m	Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22537109&form=6&db=m	Identification of a novel family of BRAF(V???E) inhibitors.	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22574151&form=6&db=m	Mechanism of cancer cell death induced by depletion of an essential replication regulator.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22607231&form=6&db=m	Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700489&form=6&db=m	Use of Kinase Inhibitors to Correct {Delta}F508-CFTR Function.	therapeutic application,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22713867&form=6&db=m	Quit your YAPing: a new target for cancer therapy.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753585&form=6&db=m	Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.	causal interaction,ongoing research,therapeutic application,unassigned	2,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22767670&form=6&db=m	Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations.	ongoing research,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22772063&form=6&db=m	Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22830020&form=6&db=m	Hippo and rassf1a Pathways: A Growing Affair.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22843098&form=6&db=m	Mitotic Failures in Cancer: Aurora B Kinase and its Potential Role in the Development of Aneuploidy.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22867812&form=6&db=m	2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23071472&form=6&db=m	Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23151618&form=6&db=m	Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,2,1	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23204235&form=6&db=m	Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23255113&form=6&db=m	Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23324574&form=6&db=m	Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,1	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23530221&form=6&db=m	Hypoxia induces a phase transition within a kinase signaling network in cancer cells.	causal interaction,ongoing research,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533274&form=6&db=m	TPL2 kinase is a suppressor of lung carcinogenesis.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536555&form=6&db=m	Trop-2 promotes prostate cancer metastasis by modulating ?1 integrin functions.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23539442&form=6&db=m	"NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors."	causal interaction,diagnostic usage,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23624904&form=6&db=m	Multiplexed tyrosine kinase activity detection in cancer cells using a hydrogel immobilized substrate.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,3,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23627634&form=6&db=m	A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer.	causal interaction,diagnostic usage,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23661421&form=6&db=m	Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23777493&form=6&db=m	Pityriasis rubra pilaris-like reaction induced by imatinib.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23912486&form=6&db=m	Importance of adrenergic pathways in women's cancers.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176670&form=6&db=m	Arsenic exposure alters expression of cell cycle and lipid metabolism genes in the liver of adult zebrafish (Danio rerio).	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24196587&form=6&db=m	Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24239188&form=6&db=m	Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352795&form=6&db=m	Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24448687&form=6&db=m	Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1-APC Interaction in Modulating Wnt/?-Catenin Pathway of Lung Cancer Cells.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24458591&form=6&db=m	cAMP-PKA inhibition of SK3 channel reduced both Ca(2+) entry and cancer cell migration by regulation of SK3-Orai1 complex.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24484538&form=6&db=m	Preclinical Drug Metabolism and Pharmacokinetics, and Prediction of Human Pharmacokinetics and Efficacious Dose of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237).	therapeutic application,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24510012&form=6&db=m	A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24642040&form=6&db=m	Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681066&form=6&db=m	Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24703947&form=6&db=m	Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24704042&form=6&db=m	Ganoderma atrum polysaccharide evokes antitumor activity via cAMP-PKA mediated apoptotic pathway and down-regulation of Ca(2+)/PKC signal pathway.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24747643&form=6&db=m	Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24751881&form=6&db=m	Neuroendocrine cancer. An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756365&form=6&db=m	Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies.	diagnostic usage,therapeutic application,unassigned	2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24769544&form=6&db=m	Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-?B/AMP-activated kinase/myosin light chain kinase pathway.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24825907&form=6&db=m	Transcriptional regulation of oncogenic protein kinase C? (PKC?) by STAT1 and Sp1 proteins.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24840251&form=6&db=m	PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,4,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24865460&form=6&db=m	mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24879333&form=6&db=m	Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: Phase 1 dose-escalation study.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24880079&form=6&db=m	XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.	therapeutic application,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24909179&form=6&db=m	PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24982612&form=6&db=m	CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25048092&form=6&db=m	miR-21 and let-7 in the Ras and NF-?B pathways.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25061104&form=6&db=m	SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGF?-independent manner.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25069672&form=6&db=m	Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25122662&form=6&db=m	Genomic analysis of fibrolamellar hepatocellular carcinoma.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162504&form=6&db=m	Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.	therapeutic application,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25396269&form=6&db=m	A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.	diagnostic usage,ongoing research,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25530832&form=6&db=m	Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25569101&form=6&db=m	Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25624177&form=6&db=m	Tumor phosphatidylinositol 3-kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: Opportunities for signaling-adapted therapies.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750087&form=6&db=m	PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia - a single-center study of 60 cases.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750740&form=6&db=m	Treatment of distant metastases from follicular cell-derived thyroid cancer.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25777618&form=6&db=m	The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.	causal interaction,therapeutic application,unassigned	4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798617&form=6&db=m	Casein kinase 1?-dependent feedback loop controls autophagy in RAS-driven cancers.	causal interaction,therapeutic application,unassigned	2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25805587&form=6&db=m	B-cell receptor signaling in diffuse large B-cell lymphoma.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25834401&form=6&db=m	The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871963&form=6&db=m	Protein kinase A defects and cortisol-producing adrenal tumors.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900113&form=6&db=m	New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25997619&form=6&db=m	Anti-chondroitin sulfate proteoglycan 4-specific antibodies modify the effects of vemurafenib on melanoma cells differentially in normoxia and hypoxia.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26042218&form=6&db=m	PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.	causal interaction,diagnostic usage,ongoing research,unassigned	4,3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26068970&form=6&db=m	Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26071104&form=6&db=m	TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26073352&form=6&db=m	Relative bioavailability of a prototype oral solution of the Aurora A kinase inhibitor alisertib (MLN8237) in patients with advanced solid tumors.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084989&form=6&db=m	Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose.	diagnostic usage,ongoing research,therapeutic application,unassigned	2,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26123587&form=6&db=m	Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine.	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26130139&form=6&db=m	Carney complex: an update.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,2,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26158292&form=6&db=m	p53 and rapamycin are additive.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26202601&form=6&db=m	Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26224641&form=6&db=m	PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246497&form=6&db=m	Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26255461&form=6&db=m	mTOR Pathway - Novel Modulator of Astrocyte Activity.	therapeutic application,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26320155&form=6&db=m	Hippo and TGF-? interplay in the lung field.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26380220&form=6&db=m	Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26445453&form=6&db=m	Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26489647&form=6&db=m	Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26516156&form=6&db=m	Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26517516&form=6&db=m	Identification of the ?-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518053&form=6&db=m	Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.	ongoing research,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26584160&form=6&db=m	A high-throughput mechanofluidic screening platform for investigating tumor cell adhesion during metastasis.	therapeutic application,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26620496&form=6&db=m	A phase I study of MK-5108, an oral aurora a kinase inhibitor, administered both as monotherapy and in combination with docetaxel, in patients with advanced or refractory solid tumors.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26674878&form=6&db=m	Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26689566&form=6&db=m	Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26739091&form=6&db=m	ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26757775&form=6&db=m	Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26892443&form=6&db=m	The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing.	diagnostic usage,ongoing research,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917778&form=6&db=m	4EBP1/c-MYC/PUMA and NF?B/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26995282&form=6&db=m	Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27027723&form=6&db=m	Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.	causal interaction,diagnostic usage,ongoing research,unassigned	2,1,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050099&form=6&db=m	N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27089349&form=6&db=m	Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model.	therapeutic application,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165862&form=6&db=m	Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.	causal interaction,diagnostic usage,therapeutic application,unassigned	2,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27184800&form=6&db=m	Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,3,4,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27192055&form=6&db=m	Open-label, multicenter, phase 1 study of alisertib (MLN8237), an aurora A kinase inhibitor, with docetaxel in patients with solid tumors.	ongoing research,therapeutic application,unassigned	2,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270477&form=6&db=m	PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27308361&form=6&db=m	PTHrP, its receptor, and protein kinase A activation in osteosarcoma.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27389594&form=6&db=m	Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446442&form=6&db=m	HPV16 E6 upregulates Aurora A expression.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470380&form=6&db=m	Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27488524&form=6&db=m	In Vivo FRET Imaging of Tumor Endothelial Cells Highlights a Role of Low PKA Activity in Vascular Hyperpermeability.	diagnostic usage,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622050&form=6&db=m	Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1? dependent upregulation of MYO3A gene in breast cancer cells.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27816996&form=6&db=m	Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27892929&form=6&db=m	A review of kinase fusions in melanocytic tumors.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27977010&form=6&db=m	TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.	causal interaction,diagnostic usage,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034990&form=6&db=m	Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,4,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28143907&form=6&db=m	Papers of note in Science Translational Medicine 9 (374).	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28147331&form=6&db=m	Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28148261&form=6&db=m	Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28185388&form=6&db=m	Characteristics of extracellular cyclic AMP-dependent protein kinase as a biomarker of cancer in dogs.	diagnostic usage,ongoing research,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28269749&form=6&db=m	Aurora-A regulates autophagy through the Akt pathway in human prostate cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,2	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270217&form=6&db=m	DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405879&form=6&db=m	Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.	diagnostic usage,ongoing research,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28469956&form=6&db=m	Targeting NRAS(Q61K) mutant delays tumor growth and angiogenesis in non-small cell lung cancer.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28601256&form=6&db=m	Aurora A Kinase Is a Priority Pharmaceutical Target for the Treatment of Cancers.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28819760&form=6&db=m	Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28852909&form=6&db=m	Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignancies.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28861148&form=6&db=m	A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28875501&form=6&db=m	The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.	causal interaction,diagnostic usage,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28891222&form=6&db=m	Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: Rationale for lower dosage in Asia.	diagnostic usage,therapeutic application,unassigned	2,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28992614&form=6&db=m	Serum and Glucocorticoid Inducible Kinase 1-Sensitive Survival, Proliferation and Migration of Rhabdomyosarcoma Cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29122619&form=6&db=m	Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,3,2	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205368&form=6&db=m	Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29219195&form=6&db=m	Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344164&form=6&db=m	Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29369420&form=6&db=m	ATM and p53 combined analysis predicts survival in glioblastoma multiforme patients: A clinicopathologic study.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29635259&form=6&db=m	Melanocytic Myxoid Spindle Cell Tumor With ALK Rearrangement (MMySTAR): Report of 4 Cases of a Nevus Variant With Potential Diagnostic Challenge.	ongoing research,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29735160&form=6&db=m	Genomic insights into Cushing syndrome.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29899121&form=6&db=m	Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30018032&form=6&db=m	Protein Kinase D2 Modulates Cell Cycle By Stabilizing Aurora A Kinase at Centrosomes.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,2,4,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30056600&form=6&db=m	Cytotoxic activity of effector T cells against cholangiocarcinoma is enhanced by self-differentiated monocyte-derived dendritic cells.	ongoing research,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30196060&form=6&db=m	Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30297384&form=6&db=m	Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30362453&form=6&db=m	[Nuclear EGFR: a new mode of oncogenic signalling in cancer].	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30373917&form=6&db=m	Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30397836&form=6&db=m	Mass balance, routes of excretion, and pharmacokinetics of investigational oral [14C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,2,2,1	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30444612&form=6&db=m	Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488763&form=6&db=m	Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597357&form=6&db=m	Update on the pathology of liver neoplasms.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30677858&form=6&db=m	Reaccion acneiforme noduloquistica secundaria a vemurafenib con buena respuesta a isotretinoina oralSevere acneiform eruption associated with vemurafenib with response to isotretinoin.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736129&form=6&db=m	cAMP and protein kinase A in endocrine (and other) tumors.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773997&form=6&db=m	Bioactive compounds in plant materials for the prevention of diabetesand obesity.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30828992&form=6&db=m	RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890157&form=6&db=m	Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30899434&form=6&db=m	Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944388&form=6&db=m	New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30973373&form=6&db=m	Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors.	causal interaction,therapeutic application,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30975030&form=6&db=m	Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30985952&form=6&db=m	Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31026276&form=6&db=m	Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133010&form=6&db=m	CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31170139&form=6&db=m	CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207362&form=6&db=m	Genomics of benign adrenocortical tumors.	causal interaction,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31223142&form=6&db=m	Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury.	therapeutic application,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262832&form=6&db=m	The AURORA of a New Way to Value Myeloid Immunosuppression in Cancer.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31269749&form=6&db=m	A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31347271&form=6&db=m	CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31586652&form=6&db=m	Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676785&form=6&db=m	DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.	diagnostic usage,ongoing research,unassigned	3,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31678302&form=6&db=m	Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31731727&form=6&db=m	Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1H-Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML).	causal interaction,diagnostic usage,therapeutic application,unassigned	4,1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31862487&form=6&db=m	BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.	therapeutic application,unassigned	1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31908303&form=6&db=m	Second-line therapies in advanced biliary tract cancers.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31911485&form=6&db=m	Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32058239&form=6&db=m	Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32091334&form=6&db=m	Plant extracts and their secondary metabolites as modulators of kinases.	diagnostic usage,therapeutic application,unassigned	2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32127406&form=6&db=m	TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32402274&form=6&db=m	Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages.	causal interaction,ongoing research,therapeutic application,unassigned	2,2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414750&form=6&db=m	Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,3,3,4	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32475979&form=6&db=m	Anti-Alzheimer's Disease Molecular Mechanism of Acori Tatarinowii Rhizoma Based on Network Pharmacology.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32507359&form=6&db=m	Adrenocortical tumorigenesis: Lessons from genetics.	causal interaction,unassigned	2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32513687&form=6&db=m	Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32696094&form=6&db=m	Wee1 kinase inhibitor AZD1775 potentiates CD8+?T cell-dependent antitumour activity via dendritic cell activation following a single high dose of irradiation.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32701199&form=6&db=m	A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study.	therapeutic application,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32707843&form=6&db=m	AniScan Using Extracellular Cyclic AMP-Dependent Protein Kinase A as a Serum Biomarker Assay for the Diagnosis of Malignant Tumors in Dogs.	diagnostic usage,ongoing research,unassigned	2,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32810137&form=6&db=m	ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821937&form=6&db=m	Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32895490&form=6&db=m	Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.	causal interaction,ongoing research,unassigned	2,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32978717&form=6&db=m	Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.	causal interaction,ongoing research,unassigned	4,2,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33000123&form=6&db=m	Targeting Corticotroph HDAC and PI3-Kinase in Cushing Disease.	ongoing research,therapeutic application,unassigned	4,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33016302&form=6&db=m	Suppression of multiple processes relevant to cancer progression by benzyl isothiocyanate may result from the inhibition of Aurora A kinase activity.	causal interaction,therapeutic application,unassigned	2,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33020594&form=6&db=m	A first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumours.	ongoing research,therapeutic application,unassigned	1,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027596&form=6&db=m	Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043474&form=6&db=m	Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33292604&form=6&db=m	Complex roles of cAMP-PKA-CREB signaling in cancer.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33368671&form=6&db=m	The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.	unassigned	-	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479856&form=6&db=m	Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.	causal interaction,unassigned	3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33776926&form=6&db=m	Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.	causal interaction,unassigned	4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33832094&form=6&db=m	Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33891611&form=6&db=m	Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,4,0	
2.7.11.11	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34343822&form=6&db=m	Role of heparanase 2 (Hpa2) in gastric cancer.	causal interaction,ongoing research,unassigned	4,3,0	
2.7.11.11	Neuralgia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295392&form=6&db=m	Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
2.7.11.11	Neuralgia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16120663&form=6&db=m	cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.	causal interaction,unassigned	3,0	
2.7.11.11	Neuralgia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889175&form=6&db=m	Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.	ongoing research,unassigned	4,0	
2.7.11.11	Neuralgia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33617945&form=6&db=m	cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain.	causal interaction,ongoing research,therapeutic application,unassigned	3,3,4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=222964&form=6&db=m	Activation of cyclic AMP-dependent protein kinase and stimulation of protein phosphorylation in response to adenosine in C-1300 murine neuroblastoma.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=231167&form=6&db=m	Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma X glioma hybrid cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332964&form=6&db=m	Characterization of a minimal promoter element required for transcription of the mouse type II beta regulatory subunit (RII beta) of cAMP-dependent protein kinase.	ongoing research,unassigned	3,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335089&form=6&db=m	Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.	ongoing research,unassigned	2,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3032279&form=6&db=m	Identification of functional cAMP-dependent protein kinase in a 'neurite minus' mouse neuroblastoma cell line.	ongoing research,unassigned	3,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6256479&form=6&db=m	Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.	unassigned	-	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6272981&form=6&db=m	Induction of the regulatory subunit of type I adenosine cyclic 3':5'-monophosphate-dependent protein kinase in differentiated N-18 mouse neuroblastoma cells.	ongoing research,unassigned	4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525897&form=6&db=m	The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene.	ongoing research,unassigned	4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8910614&form=6&db=m	The role of protein kinase C in cellular tolerance to ethanol.	therapeutic application,unassigned	3,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9125203&form=6&db=m	Type II protein kinase A up-regulation is sufficient to induce growth inhibition in SK-N-SH human neuroblastoma cells.	causal interaction,ongoing research,unassigned	4,3,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9245701&form=6&db=m	Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.	ongoing research,unassigned	2,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9648870&form=6&db=m	Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.	ongoing research,unassigned	2,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9666118&form=6&db=m	The interrelationship between selective tau phosphorylation and microtubule association.	ongoing research,unassigned	4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10653609&form=6&db=m	Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.	causal interaction,ongoing research,unassigned	3,4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11021985&form=6&db=m	Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106667&form=6&db=m	Orphanin FQ/nociceptin and mu-opioid receptor mRNA levels in human SH-SY5Y neuroblastoma cells: effects of activating the cAMP-PKA signal transduction pathway.	ongoing research,unassigned	4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332116&form=6&db=m	Inhibition of the NF-kappaB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells.	ongoing research,unassigned	3,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18831067&form=6&db=m	Regulation of relaxin 3 gene expression via cAMP-PKA in a neuroblastoma cell line.	ongoing research,unassigned	4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671766&form=6&db=m	Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,2	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22623531&form=6&db=m	Functional genomics identifies therapeutic targets for MYC-driven cancer.	unassigned	-	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23962557&form=6&db=m	Targeting GD2 ganglioside and aurora A kinase as a dual strategy leading to cell death in cultures of human neuroblastoma cells.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,3,3,1	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884555&form=6&db=m	Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial.	ongoing research,therapeutic application,unassigned	2,4,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917666&form=6&db=m	Alisertib Combined with Chemotherapy Achieves Response in Neuroblastoma.	causal interaction,therapeutic application,unassigned	1,3,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28147331&form=6&db=m	Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.	unassigned	-	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30027525&form=6&db=m	GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells.	ongoing research,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34107377&form=6&db=m	The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Neurodegenerative Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20605420&form=6&db=m	Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians.	causal interaction,unassigned	4,0	
2.7.11.11	Neurodegenerative Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701498&form=6&db=m	Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Neurodegenerative Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24672010&form=6&db=m	ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage.	causal interaction,unassigned	4,0	
2.7.11.11	Neurodegenerative Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694829&form=6&db=m	Mitochondrial cAMP-PKA signaling: What do we really know?	causal interaction,unassigned	2,0	
2.7.11.11	Neurofibromatoses	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612763&form=6&db=m	Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase.	therapeutic application,unassigned	1,0	
2.7.11.11	Neurofibromatosis 1	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612763&form=6&db=m	Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase.	therapeutic application,unassigned	1,0	
2.7.11.11	Neurofibrosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28147331&form=6&db=m	Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.	unassigned	-	
2.7.11.11	Neuroinflammatory Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32708053&form=6&db=m	Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer's Disease.	therapeutic application,unassigned	1,0	
2.7.11.11	Nevus	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29635259&form=6&db=m	Melanocytic Myxoid Spindle Cell Tumor With ALK Rearrangement (MMySTAR): Report of 4 Cases of a Nevus Variant With Potential Diagnostic Challenge.	ongoing research,unassigned	2,0	
2.7.11.11	Non-alcoholic Fatty Liver Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22857151&form=6&db=m	Antioxidative effects of Alisma orientale extract in palmitate-induced cellular injury.	causal interaction,unassigned	1,0	
2.7.11.11	non-specific serine/threonine protein kinase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403274&form=6&db=m	High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.	causal interaction,diagnostic usage,unassigned	4,3,0	
2.7.11.11	Obesity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9335553&form=6&db=m	Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Obesity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15243132&form=6&db=m	Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.	unassigned	-	
2.7.11.11	Obesity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120084&form=6&db=m	Obesity does not lead to imbalance between myocardial phospholamban phosphorylation and dephosphorylation.	causal interaction,unassigned	1,0	
2.7.11.11	Obesity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26381935&form=6&db=m	Hypothalamic PKA regulates leptin sensitivity and adiposity.	ongoing research,unassigned	3,0	
2.7.11.11	Oligodendroglioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16126335&form=6&db=m	An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,1,0	
2.7.11.11	Osteochondrodysplasias	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421483&form=6&db=m	Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.	causal interaction,unassigned	2,0	
2.7.11.11	Osteopetrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21538482&form=6&db=m	Evidence that the kinase-truncated c-Src regulates NF-?B signaling by targeting NEMO.	therapeutic application,unassigned	2,0	
2.7.11.11	Osteopetrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22282470&form=6&db=m	Accumulation of p100, a Precursor of NF-?B2, Enhances Osteoblastic Differentiation in Vitro and Bone Formation in Vivo in aly/aly Mice.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Osteoporosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28478436&form=6&db=m	Angiotensin II/Angiotensin II Receptor Blockade Affects Osteoporosis via the AT1/AT2-Mediated cAMP-Dependent PKA Pathway.	therapeutic application,unassigned	1,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1314599&form=6&db=m	The direct involvement of cAMP-dependent protein kinase in the regulation of collagen synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblast-like osteosarcoma cells (UMR-106).	ongoing research,unassigned	3,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1325405&form=6&db=m	The activation of cAMP-dependent protein kinase is directly linked to homologous desensitization by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells.	unassigned	-	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1336300&form=6&db=m	Protein kinase C modulates parathyroid hormone- but not prostaglandin E2-mediated stimulation of cyclic AMP production via the inhibitory guanine nucleotide binding protein in UMR-106 osteosarcoma cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1359985&form=6&db=m	Regulation of gene transcription and proliferation by parathyroid hormone is blocked in mutant osteoblastic cells resistant to cyclic AMP.	ongoing research,unassigned	2,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1427618&form=6&db=m	The participation of the activation of cAMP-dependent protein kinase in cytosolic acidification by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2555128&form=6&db=m	Glucocorticoid and 1,25-dihydroxyvitamin D modulate the degree of adenosine 3',5'-monophosphate-dependent protein kinase isoenzyme I and II activation by parathyroid hormone in rat osteosarcoma cells.	ongoing research,unassigned	2,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009148&form=6&db=m	Glucocorticoid treatment facilitates cyclic adenosine 3',5'-monophosphate-dependent protein kinase response in parathyroid hormone-responsive osteogenic sarcoma cells.	therapeutic application,unassigned	4,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6257486&form=6&db=m	Activation of adenosine 3',5'-monophosphate-dependent protein kinase in normal and malignant bone cells by parathyroid hormone, prostaglandin E2, and prostacyclin.	ongoing research,unassigned	4,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6282567&form=6&db=m	Activity ratio measurements reflect intracellular activation of adenosine 3',5'-monophosphate-dependent protein kinase in osteoblasts.	causal interaction,ongoing research,unassigned	2,4,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6294086&form=6&db=m	Selective hormonal activation of cyclic AMP-dependent protein kinase isoenzymes in normal and malignant osteoblasts.	ongoing research,unassigned	4,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8119663&form=6&db=m	Role of calcium/protein kinase C in the regulation of DNA synthesis by parathyroid hormone-related peptide in osteoblastic osteosarcoma cells.	ongoing research,unassigned	2,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25236161&form=6&db=m	A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,4,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807203&form=6&db=m	MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation.	causal interaction,ongoing research,therapeutic application,unassigned	2,4,4,0	
2.7.11.11	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27308361&form=6&db=m	PTHrP, its receptor, and protein kinase A activation in osteosarcoma.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,1,0	
2.7.11.11	Otitis Media	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32760078&form=6&db=m	A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media.	unassigned	-	
2.7.11.11	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15905176&form=6&db=m	Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18822129&form=6&db=m	Regulatory subunits of PKA define an axis of cellular proliferation/ differentiation in ovarian cancer cells.	ongoing research,unassigned	4,0	
2.7.11.11	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22772063&form=6&db=m	Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.	causal interaction,diagnostic usage,ongoing research,unassigned	4,2,4,0	
2.7.11.11	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900113&form=6&db=m	New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881569&form=6&db=m	Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,4,0	
2.7.11.11	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32974133&form=6&db=m	Targeting Aurora A Kinase (AAK) in Platinum-Resistant High Grade Serous Ovarian Cancer.	causal interaction,diagnostic usage,unassigned	2,2,0	
2.7.11.11	Pancreatic Cyst	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31678302&form=6&db=m	Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.	diagnostic usage,ongoing research,unassigned	1,3,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631597&form=6&db=m	Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.	ongoing research,unassigned	3,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15805292&form=6&db=m	RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.	causal interaction,unassigned	2,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815537&form=6&db=m	Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.	causal interaction,ongoing research,unassigned	3,1,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20454507&form=6&db=m	GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23054975&form=6&db=m	Interactions of everolimus and sorafenib in pancreatic cancer cells.	causal interaction,unassigned	3,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27909956&form=6&db=m	Docking and three-dimensional quantitative structure-activity relationship analyses of imidazole and thiazolidine derivatives as Aurora A kinase inhibitors.	causal interaction,ongoing research,unassigned	4,2,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228685&form=6&db=m	EB1 phosphorylation mediates the functions of ASK1 in pancreatic cancer development.	causal interaction,diagnostic usage,unassigned	1,2,0	
2.7.11.11	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32193808&form=6&db=m	Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer.	causal interaction,therapeutic application,unassigned	3,3,0	
2.7.11.11	Pancreatitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14622690&form=6&db=m	Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.	therapeutic application,unassigned	4,0	
2.7.11.11	Paralysis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16571668&form=6&db=m	Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility.	unassigned	-	
2.7.11.11	Paraplegia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11276122&form=6&db=m	Molecular pathways of oligodendrocyte apoptosis revealed by mutations in the proteolipid protein gene.	causal interaction,unassigned	3,0	
2.7.11.11	Parasitic Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19707280&form=6&db=m	A Schistosome cAMP-Dependent Protein Kinase Catalytic Subunit Is Essential for Parasite Viability.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Parathyroid Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3450512&form=6&db=m	Phospholipid/Ca2+-dependent protein kinase activity in human parathyroid adenoma.	unassigned	-	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19076219&form=6&db=m	Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19152501&form=6&db=m	Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking (dagger).	causal interaction,unassigned	1,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20624856&form=6&db=m	Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.	causal interaction,unassigned	4,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21547489&form=6&db=m	Akt as a Victim, Villain and Potential Hero in Parkinson's Disease Pathophysiology and Treatment.	causal interaction,unassigned	4,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21858031&form=6&db=m	LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding.	therapeutic application,unassigned	1,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21960214&form=6&db=m	Measuring the activity of leucine-rich repeat kinase 2: a kinase involved in Parkinson's disease.	causal interaction,diagnostic usage,unassigned	4,2,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22998870&form=6&db=m	LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.	causal interaction,unassigned	1,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24351927&form=6&db=m	Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.	therapeutic application,unassigned	1,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24965893&form=6&db=m	The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.	ongoing research,unassigned	2,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26375402&form=6&db=m	Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27914807&form=6&db=m	Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor ?-mediated neurotoxicity.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28408230&form=6&db=m	Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods.	causal interaction,unassigned	3,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29891719&form=6&db=m	Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF?-mediated apoptosis.	causal interaction,unassigned	3,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30481056&form=6&db=m	DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006315&form=6&db=m	Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.	causal interaction,unassigned	2,0	
2.7.11.11	Parkinson Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33857132&form=6&db=m	Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease.	causal interaction,unassigned	3,0	
2.7.11.11	Parkinsonian Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=223544&form=6&db=m	Cyclic AMP-dependent protein kinase activity in the human brain: values in Parkinsonism.	diagnostic usage,ongoing research,unassigned	3,3,0	
2.7.11.11	Pelizaeus-Merzbacher Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11276122&form=6&db=m	Molecular pathways of oligodendrocyte apoptosis revealed by mutations in the proteolipid protein gene.	causal interaction,unassigned	3,0	
2.7.11.11	Peripheral Vascular Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1713458&form=6&db=m	Comparison of vasodilatory prostaglandins with respect to cAMP-mediated phosphorylation of a target substrate in intact human platelets.	therapeutic application,unassigned	3,0	
2.7.11.11	Peutz-Jeghers Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15733742&form=6&db=m	AMP-activated protein kinase: balancing the scales.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25946&form=6&db=m	Activation of rat pheochromocytoma tyrosine hydroxylase by a cyclic AMP-dependent protein kinase in a cell-free system.	ongoing research,unassigned	1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1311713&form=6&db=m	The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.	ongoing research,unassigned	4,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1671583&form=6&db=m	Phosphorylation of rat tyrosine hydroxylase and its model peptides in vitro by cyclic AMP-dependent protein kinase.	diagnostic usage,ongoing research,unassigned	2,3,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2156866&form=6&db=m	Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2184346&form=6&db=m	Immunofluorescence localization of the regulatory subunit type II of cAMP-dependent protein kinase in PC12 and 3T3 cells in different proliferative states.	ongoing research,unassigned	4,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2474460&form=6&db=m	Regulation of human tyrosine hydroxylase activity. Effects of cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion.	diagnostic usage,ongoing research,unassigned	1,4,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2576179&form=6&db=m	Regulation of the activity of tyrosine hydroxylase in the central nervous system.	unassigned	-	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2850967&form=6&db=m	Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.	ongoing research,unassigned	4,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2867128&form=6&db=m	Enhanced phosphorylation of tyrosine hydroxylase at more than one site is induced by 56 mM K+ in rat pheochromocytoma PC12 cells in culture.	causal interaction,unassigned	1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2874140&form=6&db=m	Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.	unassigned	-	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2879892&form=6&db=m	Phosphorylation of tyrosine hydroxylase by cyclic GMP-dependent protein kinase.	diagnostic usage,unassigned	1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2883182&form=6&db=m	Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.	causal interaction,unassigned	4,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2902626&form=6&db=m	Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.	ongoing research,unassigned	2,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6102382&form=6&db=m	Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,1,1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6150037&form=6&db=m	Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.	ongoing research,unassigned	1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7525897&form=6&db=m	The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene.	ongoing research,unassigned	4,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9525930&form=6&db=m	The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721736&form=6&db=m	The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells.	ongoing research,unassigned	4,0	
2.7.11.11	Pheochromocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911134&form=6&db=m	Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells.	ongoing research,unassigned	3,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1328659&form=6&db=m	Increased activity of type I regulatory subunit of cyclic adenosine 3',5'-monophosphate-dependent protein kinase in estrogen-induced pituitary tumors.	causal interaction,ongoing research,unassigned	1,1,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166038&form=6&db=m	Post-transcriptional regulation of cAMP-dependent protein kinase activity by cAMP in GH3 pituitary tumor cells. Evidence for increased degradation of catalytic subunit in the presence of cAMP.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2823094&form=6&db=m	Activators of protein kinase C and cyclic AMP-dependent protein kinase regulate intracellular calcium levels through distinct mechanisms in mouse anterior pituitary tumor cells.	causal interaction,ongoing research,therapeutic application,unassigned	1,4,1,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2999799&form=6&db=m	Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.	causal interaction,unassigned	2,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3009490&form=6&db=m	Liposome delivery of cyclic AMP-dependent protein kinase inhibitor into intact cells: specific blockade of cyclic AMP-mediated adrenocorticotropin release from mouse anterior pituitary tumor cells.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088493&form=6&db=m	Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. Preferential activation of protein kinase I by corticotropin releasing factor, isoproterenol, and forskolin.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10526256&form=6&db=m	Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,1,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169386&form=6&db=m	Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway.	causal interaction,unassigned	4,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204369&form=6&db=m	Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas.	causal interaction,diagnostic usage,ongoing research,unassigned	1,2,4,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17613552&form=6&db=m	Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis.	causal interaction,unassigned	4,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24606125&form=6&db=m	Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis.	ongoing research,unassigned	3,0	
2.7.11.11	Pituitary Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31586652&form=6&db=m	Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Plasmacytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192298&form=6&db=m	Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Pneumonia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32890967&form=6&db=m	Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and COVID-19.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Polycystic Kidney Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10767293&form=6&db=m	Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.	causal interaction,unassigned	1,0	
2.7.11.11	Polycystic Kidney Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880258&form=6&db=m	cAMP-dependent protein kinase and proliferation differ in normal and polycystic kidney epithelia.	ongoing research,unassigned	3,0	
2.7.11.11	Polycystic Kidney Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31183407&form=6&db=m	Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.	ongoing research,unassigned	1,0	
2.7.11.11	Polycystic Kidney, Autosomal Dominant	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26202352&form=6&db=m	The Effect of cAMP-PKA Activation on TGF-?1-Induced Profibrotic Signaling.	causal interaction,ongoing research,unassigned	3,2,0	
2.7.11.11	Polycystic Kidney, Autosomal Dominant	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31183407&form=6&db=m	Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.	ongoing research,unassigned	1,0	
2.7.11.11	Polycystic Kidney, Autosomal Dominant	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830556&form=6&db=m	Proliferative signaling by ERBB proteins and RAF/MEK/ERK effectors in polycystic kidney disease.	causal interaction,unassigned	3,0	
2.7.11.11	Polycythemia Vera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19521323&form=6&db=m	The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Polycythemia Vera	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042281&form=6&db=m	Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Pre-Eclampsia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676926&form=6&db=m	Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.	causal interaction,unassigned	2,0	
2.7.11.11	Precursor Cell Lymphoblastic Leukemia-Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34233449&form=6&db=m	Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia.	causal interaction,therapeutic application,unassigned	4,4,0	
2.7.11.11	Primary Myelofibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19521323&form=6&db=m	The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Primary Myelofibrosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24091929&form=6&db=m	Advances in myelofibrosis: a clinical case approach.	causal interaction,unassigned	4,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873081&form=6&db=m	Extracellular catalytic subunit activity of the cAMP-dependent protein kinase in prostate cancer.	diagnostic usage,ongoing research,unassigned	4,3,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880182&form=6&db=m	Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12084720&form=6&db=m	Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075275&form=6&db=m	Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae.	causal interaction,unassigned	1,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781644&form=6&db=m	Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway.	causal interaction,ongoing research,unassigned	3,3,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15929083&form=6&db=m	Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action.	causal interaction,unassigned	4,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19653278&form=6&db=m	Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,4,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813184&form=6&db=m	Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: Cross-talk with the androgen receptor.	causal interaction,diagnostic usage,unassigned	1,3,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21310466&form=6&db=m	Quantitative Assessment of AKAP12 Promoter Methylation in Human Prostate Cancer Using Methylation-sensitive High-resolution Melting: Correlation With Gleason Score.	diagnostic usage,ongoing research,unassigned	3,4,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025384&form=6&db=m	Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness.	diagnostic usage,unassigned	4,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986532&form=6&db=m	Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer.	diagnostic usage,unassigned	3,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23736698&form=6&db=m	Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type i? of protein kinase a in vivo.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24186207&form=6&db=m	Androgens regulate prostate cancer cell growth via an AMPK-PGC-1?-mediated metabolic switch.	therapeutic application,unassigned	1,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26152593&form=6&db=m	Recepteur d'origine nantais (RON), more than a kinase: Role in castrate-resistant prostate cancer.	causal interaction,unassigned	3,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26493492&form=6&db=m	Saracatinib as a metastasis inhibitor in metastatic castration-resistant prostate cancer: A University of Chicago Phase 2 Consortium and DOD/PCF Prostate Cancer Clinical Trials Consortium Study.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27070695&form=6&db=m	Defining and Targeting the Oncogenic Drivers of Neuroendocrine Prostate Cancer.	therapeutic application,unassigned	3,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28178640&form=6&db=m	A Phase I/II Study of the Investigational Drug Alisertib in Combination With Abiraterone and Prednisone for Patients With Metastatic Castration-Resistant Prostate Cancer Progressing on Abiraterone.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,2,0	
2.7.11.11	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33492659&form=6&db=m	The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,3,1,0	
2.7.11.11	protein acetyllysine n-acetyltransferase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33542782&form=6&db=m	Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice.	ongoing research,therapeutic application,unassigned	3,2,0	
2.7.11.11	Pseudorabies	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105215&form=6&db=m	Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.	ongoing research,unassigned	2,0	
2.7.11.11	Psoriasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615649&form=6&db=m	Post-translational abnormality of the type II cyclic AMP-dependent protein kinase in psoriasis: modulation by retinoic acid.	ongoing research,unassigned	4,0	
2.7.11.11	Psoriasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013125&form=6&db=m	Oxidative modulation of cyclic AMP-dependent protein kinase in human fibroblasts: possible role in psoriasis.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Psoriasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846304&form=6&db=m	Preferential inhibition of the mRNA expression of p38 MAPK regulated cytokines in psoriatic skin by anti-TNF? therapy.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Pulmonary Disease, Chronic Obstructive	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110061&form=6&db=m	Progress in the mechanism and targeted drug therapy for COPD.	causal interaction,therapeutic application,unassigned	2,1,0	
2.7.11.11	Reperfusion Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12798433&form=6&db=m	Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity.	unassigned	-	
2.7.11.11	Reperfusion Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19111324&form=6&db=m	Implication of Protein Kinase A for a Hepato-Protective Mechanism of Milrinone Pretreatment.	causal interaction,diagnostic usage,ongoing research,therapeutic application	1,3,4,3	
2.7.11.11	Reperfusion Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22532103&form=6&db=m	Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation via cAMP-PKA pathway.	unassigned	-	
2.7.11.11	Reperfusion Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29310813&form=6&db=m	Effect of sevoflurane on the ATPase activity of hippocampal neurons in a rat model of cerebral ischemia-reperfusion injury via the cAMP-PKA signaling pathway.	ongoing research,unassigned	3,0	
2.7.11.11	Retinoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2714411&form=6&db=m	Abnormal expression of the RI subunit of cyclic AMP-dependent protein kinase in Y-79 retinoblastoma cells.	ongoing research,unassigned	1,0	
2.7.11.11	Retinoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3528034&form=6&db=m	Distribution of the regulatory subunit of type II cAMP-dependent protein kinase in Y-79 retinoblastoma cells. Effect of butyrate.	ongoing research,unassigned	4,0	
2.7.11.11	Retinoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10788799&form=6&db=m	IL-1 induces expression of p21(WAF1) independently of p53 in high-passage human embryonic fibroblasts WI38.	therapeutic application,unassigned	1,0	
2.7.11.11	Retinoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15024128&form=6&db=m	Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.	ongoing research,unassigned	2,0	
2.7.11.11	Retinoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19654912&form=6&db=m	Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor.	therapeutic application,unassigned	2,0	
2.7.11.11	Retinoblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20838604&form=6&db=m	Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases.	causal interaction,unassigned	4,0	
2.7.11.11	Rhabdomyosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31888889&form=6&db=m	Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.	unassigned	-	
2.7.11.11	Salmonella Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23990921&form=6&db=m	Multiple Host Kinases Contribute to Akt Activation during Salmonella Infection.	causal interaction,unassigned	4,0	
2.7.11.11	Sandhoff Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21298000&form=6&db=m	Prostaglandin E2 reverses aberrant production of an inflammatory chemokine by microglia from Sandhoff disease model mice through the cAMP-PKA pathway.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,1,0	
2.7.11.11	Sarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6283546&form=6&db=m	Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.	ongoing research,unassigned	1,0	
2.7.11.11	Sarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199087&form=6&db=m	Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group.	causal interaction,therapeutic application,unassigned	3,2,0	
2.7.11.11	Sarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20421483&form=6&db=m	Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.	causal interaction,unassigned	2,0	
2.7.11.11	Sarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24058690&form=6&db=m	Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome.	ongoing research,unassigned	1,0	
2.7.11.11	Sarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32701199&form=6&db=m	A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study.	therapeutic application,unassigned	3,0	
2.7.11.11	Sarcoma, Avian	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=52872&form=6&db=m	Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Sarcoma, Avian	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6270200&form=6&db=m	Comparison of cAMP-dependent protein kinase in normal and Rous sarcoma virus transformed chick embryo fibroblasts.	diagnostic usage,ongoing research,unassigned	3,3,0	
2.7.11.11	Sarcoma, Avian	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6280857&form=6&db=m	Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein.	unassigned	-	
2.7.11.11	Sarcoma, Avian	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6281757&form=6&db=m	Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.	diagnostic usage,therapeutic application,unassigned	1,1,0	
2.7.11.11	Sarcoma, Avian	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11089528&form=6&db=m	Concerted regulation of steroidogenic acute regulatory gene expression by luteinizing hormone and insulin (or insulin-like growth factor I) in primary cultures of porcine granulosa-luteal cells.	unassigned	-	
2.7.11.11	Sarcoma, Kaposi	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11056537&form=6&db=m	The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Schistosomiasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20109453&form=6&db=m	Conservation of protein kinase a catalytic subunit sequences in the schistosome pathogens of humans.	therapeutic application,unassigned	3,0	
2.7.11.11	Seizures	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2795022&form=6&db=m	Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex.	unassigned	-	
2.7.11.11	Seizures	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16176064&form=6&db=m	Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures.	causal interaction,ongoing research,unassigned	4,3,0	
2.7.11.11	Seizures	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26165472&form=6&db=m	Activation of death-associated protein kinase in human peritumoral tissue: A potential therapeutic target.	ongoing research,unassigned	1,0	
2.7.11.11	Seizures	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27716957&form=6&db=m	Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.	causal interaction,unassigned	4,0	
2.7.11.11	Seizures	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30511325&form=6&db=m	Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA Pathway.	causal interaction,therapeutic application,unassigned	4,1,0	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1294761&form=6&db=m	[Kinetic studies of protein kinase A in rat liver during late sepsis]	causal interaction,ongoing research,therapeutic application,unassigned	2,4,1,0	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7481874&form=6&db=m	[Impaired calcium uptake by cardiac sarcoplasmic reticulum and its underlying mechanism during rat septic shock]	ongoing research,unassigned	1,0	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249915&form=6&db=m	Protein kinase a activity is increased in rat heart during late hypodynamic phase of sepsis.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,4,3	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9299285&form=6&db=m	Differential activation of protein kinase A in various regions of myocardium during sepsis.	ongoing research,unassigned	3,0	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9389165&form=6&db=m	[Changes in the calcium channels in rat cardiac cells during sepsis]	unassigned	-	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10509629&form=6&db=m	Liver protein kinase A activity is decreased during the late hypoglycemic phase of sepsis.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,1,4,1	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887504&form=6&db=m	Protection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of beta2-adrenoceptor.	unassigned	-	
2.7.11.11	Sepsis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275604&form=6&db=m	Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury.	causal interaction,ongoing research,unassigned	1,4,0	
2.7.11.11	Skin Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33558670&form=6&db=m	CDC42BPA/MRCK?: a kinase target for brain, ovarian and skin cancers.	diagnostic usage,unassigned	1,0	
2.7.11.11	Spinal Cord Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18656458&form=6&db=m	Spinal activation of the cAMP-PKA pathway induces respiratory motor recovery following high cervical spinal cord injury.	unassigned	-	
2.7.11.11	Spinal Cord Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2547909&form=6&db=m	Reduced protein kinase C activity in ischemic spinal cord.	ongoing research,unassigned	2,0	
2.7.11.11	Spinocerebellar Ataxias	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18037885&form=6&db=m	Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.	causal interaction,unassigned	4,0	
2.7.11.11	Spinocerebellar Ataxias	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23754227&form=6&db=m	Regulation of ataxin-1 phosphorylation and its impact on biology.	ongoing research,unassigned	1,0	
2.7.11.11	Squamous Cell Carcinoma of Head and Neck	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955398&form=6&db=m	Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,3,4	
2.7.11.11	Squamous Cell Carcinoma of Head and Neck	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30755439&form=6&db=m	Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck.	causal interaction,therapeutic application,unassigned	1,3,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2837458&form=6&db=m	Modulation of expression of the stress-inducible p118 of Saccharomyces cerevisiae by cAMP. II. A study of p118 expression in mutants of the cAMP cascade.	ongoing research,unassigned	1,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3037314&form=6&db=m	Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7862141&form=6&db=m	The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.	diagnostic usage,ongoing research,unassigned	3,1,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8832415&form=6&db=m	The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.	ongoing research,unassigned	1,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9387223&form=6&db=m	The lag phase rather than the exponential-growth phase on glucose is associated with a higher cAMP level in wild-type and cAPK-attenuated strains of the yeast Saccharomyces cerevisiae.	unassigned	-	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9744870&form=6&db=m	Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase.	causal interaction,unassigned	2,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10375515&form=6&db=m	Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway.	unassigned	-	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10982411&form=6&db=m	A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development.	ongoing research,unassigned	1,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863676&form=6&db=m	Crosstalk between cAMP-PKA and MAP kinase pathways is a key regulatory design necessary to regulate FLO11 expression.	unassigned	-	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18687406&form=6&db=m	RAM pathway contributes to Rpb4 dependent pseudohyphal differentiation in Saccharomyces cerevisiae.	unassigned	-	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20691155&form=6&db=m	Phosphorylation of the protein kinase A catalytic subunit is induced by cyclic AMP deficiency and physiological stresses in the fission yeast, Schizosaccharomyces pombe.	causal interaction,unassigned	4,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25695491&form=6&db=m	Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo.	unassigned	-	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26941227&form=6&db=m	Coordination of cell decisions and promotion of phenotypic diversity in B. subtilis via pulsed behavior of the phosphorelay.	unassigned	-	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32409581&form=6&db=m	AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,3,0	
2.7.11.11	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363697&form=6&db=m	Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans.	causal interaction,unassigned	2,0	
2.7.11.11	Stomach Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10322859&form=6&db=m	[Regulation of traditional Chinese medicine formulae bailong on cAMP-PKA and DAG-PKC signal pathways of human gastric cancer cells]	ongoing research,unassigned	3,0	
2.7.11.11	Stomach Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34002415&form=6&db=m	Identification of kinases and kinase inhibitors for the differential targeting of Wnt/?-catenin signaling in gastric cancer subtypes.	therapeutic application,unassigned	4,0	
2.7.11.11	Telangiectasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313465&form=6&db=m	Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1.	unassigned	-	
2.7.11.11	Telangiectasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17102619&form=6&db=m	Microcephalin: a causal link between impaired damage response signalling and microcephaly.	causal interaction,unassigned	3,0	
2.7.11.11	Telangiectasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727557&form=6&db=m	N-hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells.	unassigned	-	
2.7.11.11	Telangiectasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25742469&form=6&db=m	ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Teratocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3664484&form=6&db=m	Retinoic acid-induced rapid loss of nuclear cyclic AMP-dependent protein kinase in teratocarcinoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	2,3,1,0	
2.7.11.11	Teratocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9419418&form=6&db=m	Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity.	ongoing research,unassigned	3,0	
2.7.11.11	Tetanus	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11859926&form=6&db=m	Tetanus toxin modulates serotonin transport in rat-brain neuronal cultures.	therapeutic application,unassigned	1,0	
2.7.11.11	Thrombocythemia, Essential	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19521323&form=6&db=m	The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Thrombosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21852354&form=6&db=m	Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.	causal interaction,ongoing research,unassigned	1,2,0	
2.7.11.11	Thymoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9668102&form=6&db=m	Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa.	ongoing research,unassigned	1,0	
2.7.11.11	Thyroid Cancer, Papillary	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8528355&form=6&db=m	Growth regulation of the human papillary thyroid cancer cell line by protein tyrosine kinase and cAMP-dependent protein kinase.	ongoing research,unassigned	4,0	
2.7.11.11	Thyroid Cancer, Papillary	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8662982&form=6&db=m	Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain.	unassigned	-	
2.7.11.11	Thyroid Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18799615&form=6&db=m	Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.	ongoing research,unassigned	3,0	
2.7.11.11	Thyroid Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25232968&form=6&db=m	Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Thyroid Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512660&form=6&db=m	Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles.	diagnostic usage,therapeutic application,unassigned	3,4,0	
2.7.11.11	Thyroid Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30226440&form=6&db=m	c-Myc is a major determinant for antitumor activity of Aurora A kinase inhibitor MLN8237 in thyroid cancer.	causal interaction,therapeutic application,unassigned	1,2,0	
2.7.11.11	Triple Negative Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27593935&form=6&db=m	Aurora A kinase activates YAP signaling in triple-negative breast cancer.	causal interaction,ongoing research,unassigned	3,2,0	
2.7.11.11	Triple Negative Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28262781&form=6&db=m	WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Triple Negative Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262335&form=6&db=m	A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,2,4,0	
2.7.11.11	Triple Negative Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414750&form=6&db=m	Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,3,3,4	
2.7.11.11	Triple Negative Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32468675&form=6&db=m	Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells.	therapeutic application,unassigned	2,0	
2.7.11.11	Trypanosomiasis, African	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23853715&form=6&db=m	Closing in on a new treatment for sleeping sickness.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Tuberculosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20934382&form=6&db=m	Leads for antitubercular compounds from kinase inhibitor library screens.	therapeutic application,unassigned	2,0	
2.7.11.11	Tuberculosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29438524&form=6&db=m	Elevated cyclic AMP Inhibits Mycobacterium tuberculosis-stimulated T cell IFN-? Secretion through type I Protein Kinase A.	therapeutic application,unassigned	1,0	
2.7.11.11	Tuberous Sclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681023&form=6&db=m	AMPK, the metabolic syndrome and cancer.	causal interaction,unassigned	4,0	
2.7.11.11	Tuberous Sclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21300751&form=6&db=m	Early activation of mTORC1 in response to mechanical overload is independent of PI3K/Akt signaling.	therapeutic application,unassigned	1,0	
2.7.11.11	Tuberous Sclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26393506&form=6&db=m	Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein.	therapeutic application,unassigned	1,0	
2.7.11.11	Tuberous Sclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30589121&form=6&db=m	Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High-Content Drug Screening.	therapeutic application,unassigned	3,0	
2.7.11.11	Urinary Bladder Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24562316&form=6&db=m	Aurora A Kinase as a diagnostic urinary marker for urothelial bladder cancer.	diagnostic usage,therapeutic application,unassigned	4,1,0	
2.7.11.11	Urinary Bladder Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28269755&form=6&db=m	MicroRNA-124-3p affects proliferation, migration and apoptosis of bladder cancer cells through targeting AURKA.	diagnostic usage,ongoing research,unassigned	4,4,0	
2.7.11.11	Uterine Cervical Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19059698&form=6&db=m	Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,3,1	
2.7.11.11	Uterine Cervical Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31774882&form=6&db=m	Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237.	therapeutic application,unassigned	2,0	
2.7.11.11	Vascular Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12016269&form=6&db=m	Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Vascular System Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9212106&form=6&db=m	Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Vascular System Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179200&form=6&db=m	Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals.	causal interaction,therapeutic application,unassigned	3,4,0	
2.7.11.11	Vascular System Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30036880&form=6&db=m	Analysis of Genes Related to Angiotensin II-Induced Arterial Injury Using a Time Series Microarray.	causal interaction,therapeutic application,unassigned	3,1,0	
2.7.11.11	Vasospasm, Intracranial	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690734&form=6&db=m	Thin and thick filament regulation of contractility in experimental cerebral vasospasm.	ongoing research,unassigned	3,0	
2.7.11.11	Vesicular Stomatitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2849432&form=6&db=m	Inhibitory effect of glycyrrhizin on polypeptide phosphorylation by polypeptide-dependent protein kinase (kinase P) in vitro.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Vesicular Stomatitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30852272&form=6&db=m	Macropinocytosis contributes to hantavirus entry into human airway epithelial cells.	therapeutic application,unassigned	3,0	
2.7.11.11	Virus Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2201134&form=6&db=m	Frog virus 3-mediated translational shut-off: frog virus 3 messages are translationally more efficient than host and heterologous viral messages under conditions of increased translational stress.	causal interaction,therapeutic application,unassigned	2,2,0	
2.7.11.11	Virus Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10627526&form=6&db=m	Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,1,0	
2.7.11.11	Virus Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26354181&form=6&db=m	IKK? negatively regulates RIG-I via direct phosphorylation.	therapeutic application,unassigned	1,0	
2.7.11.11	Virus Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32922394&form=6&db=m	Polarized Trout Epithelial Cells Regulate Transepithelial Electrical Resistance, Gene Expression, and the Phosphoproteome in Response to Viral Infection.	causal interaction,unassigned	1,0	
2.7.11.11	Virus Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34123875&form=6&db=m	Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi.	causal interaction,therapeutic application,unassigned	2,3,0	
2.7.11.11	Vitamin D Deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3145117&form=6&db=m	Effect of vitamin D status on the activity of carbonic anhydrase in chicken epiphysis and kidney.	causal interaction,unassigned	4,0	
2.7.11.11	Vitamin D Deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6270131&form=6&db=m	Effect of vitamin D status on cyclic AMP-dependent protein kinase activity and its heat-stable inhibitor in chick kidney.	causal interaction,unassigned	4,0	
2.7.11.11	Vitamin D Deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6305597&form=6&db=m	Cyclic AMP dependent protein kinase and its endogenous inhibitor protein: tissue distribution and effect of vitamin D status in the chick.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,3,1,0	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122320&form=6&db=m	Make WARTS, not cancer!	therapeutic application,unassigned	1,0	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20159598&form=6&db=m	Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.	unassigned	-	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20797625&form=6&db=m	Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.	causal interaction,therapeutic application,unassigned	1,1,0	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556047&form=6&db=m	Modulating F-actin organization induces organ growth by affecting the Hippo pathway.	unassigned	-	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22055343&form=6&db=m	Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate.	unassigned	-	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22840522&form=6&db=m	Homeodomain-interacting protein kinase regulates yorkie activity to promote tissue growth.	therapeutic application,unassigned	1,0	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23263283&form=6&db=m	Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.	unassigned	-	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24106343&form=6&db=m	Hippo Gains Weight: Added Insights and Complexity to Pathway Control.	unassigned	-	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26685188&form=6&db=m	The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis.	unassigned	-	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31170139&form=6&db=m	CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation.	unassigned	-	
2.7.11.11	Warts	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33869224&form=6&db=m	Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View.	therapeutic application,unassigned	1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2438697&form=6&db=m	Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.	ongoing research,therapeutic application,unassigned	2,1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507846&form=6&db=m	Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus.	causal interaction,unassigned	3,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820995&form=6&db=m	Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2842188&form=6&db=m	Effects of phosphorylation of inhibitory GTP-binding protein by cyclic AMP-dependent protein kinase on its ADP-ribosylation by pertussis toxin, islet-activating protein.	ongoing research,therapeutic application,unassigned	1,1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846548&form=6&db=m	Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592840&form=6&db=m	Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7620887&form=6&db=m	The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7705463&form=6&db=m	Activation of metabotropic glutamate receptors by L-AP4 stimulates survival of rat cerebellar granule cells in culture.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8306196&form=6&db=m	Neural effects of parathyroid hormone: modulation of the calcium channel current and metabolism of monoamines in identified Helisoma snail neurons.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443926&form=6&db=m	Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458196&form=6&db=m	Biochemical investigation of cell motile activity in rheumatoid synovial fluid.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654360&form=6&db=m	ATP produces potassium currents via P3 purinoceptor in the follicle cell layer of Xenopus oocytes.	therapeutic application,unassigned	3,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9712151&form=6&db=m	SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364208&form=6&db=m	Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells.	therapeutic application,unassigned	2,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840035&form=6&db=m	beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11021985&form=6&db=m	Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.	ongoing research,therapeutic application,unassigned	3,1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11053220&form=6&db=m	Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.	therapeutic application,unassigned	1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062237&form=6&db=m	N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.	therapeutic application,unassigned	1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665541&form=6&db=m	Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.	therapeutic application,unassigned	2,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16006245&form=6&db=m	Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer.	therapeutic application,unassigned	1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16148159&form=6&db=m	Differential calcium regulation of proinflammatory activities in human neutrophils exposed to the neuropeptide pituitary adenylate cyclase-activating protein.	ongoing research,unassigned	2,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16888186&form=6&db=m	Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils.	ongoing research,unassigned	3,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577183&form=6&db=m	Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.	therapeutic application,unassigned	1,0	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19416170&form=6&db=m	Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883692&form=6&db=m	17?-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor.	unassigned	-	
2.7.11.11	Whooping Cough	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619154&form=6&db=m	Structural insight into the role of the PAS domainfor signal transduction in sensor-kinase BvgS.	unassigned	-	
2.7.11.11	Wilms Tumor	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6091871&form=6&db=m	Distribution and properties of type I and type II binding proteins in the cyclic adenosine 3':5'-monophosphate-dependent protein kinase system in Wilms' tumor.	causal interaction,unassigned	3,0	
2.7.11.11	X-Linked Combined Immunodeficiency Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8795294&form=6&db=m	Dysfunctional cytokine receptor signaling in severe combined immunodeficiency.	causal interaction,unassigned	4,0	
2.7.11.11	Yellow Fever	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21858043&form=6&db=m	The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly.	ongoing research,therapeutic application,unassigned	2,4,0