2.7.11.10 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24917786&form=6&db=m In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19546526&form=6&db=m Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12831615&form=6&db=m [Potential molecular mechanism of multiple organ dysfunction syndrome induced by hemorrhage and endotoxin] causal interaction,unassigned 4,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11515677&form=6&db=m Cytokine-activated degradation of inhibitory kappaB protein alpha is inhibited by the short-chain fatty acid butyrate. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12725325&form=6&db=m Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16353139&form=6&db=m GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664134&form=6&db=m Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30105668&form=6&db=m Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.7.11.10 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19243472&form=6&db=m Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17132819&form=6&db=m Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18466396&form=6&db=m Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19296948&form=6&db=m Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis. diagnostic usage,unassigned 1,0 2.7.11.10 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17093946&form=6&db=m Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Agammaglobulinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604887&form=6&db=m Autosomal-dominant primary immunodeficiencies. therapeutic application,unassigned 1,0 2.7.11.10 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33044112&form=6&db=m SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation. diagnostic usage,unassigned 3,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18312546&form=6&db=m Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis. ongoing research,unassigned 4,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27156075&form=6&db=m TBK1 is associated with ALS and ALS-FTD in Sardinian patients. therapeutic application,unassigned 1,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27260353&form=6&db=m Screening of the TBK1 gene in familial and sporadic amyotrophic lateral sclerosis patients of Chinese origin. therapeutic application,unassigned 2,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570907&form=6&db=m [A Pair of Siblings with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and a Novel Thr462Lysfs Mutation in the TBK1 Gene]. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27939697&form=6&db=m Genetic and functional analysis of TBK1 variants in Korean patients with sporadic amyotrophic lateral sclerosis. therapeutic application,unassigned 1,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008748&form=6&db=m TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. ongoing research,unassigned 2,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28822984&form=6&db=m TBK1 mutations in Italian patients with amyotrophic lateral sclerosis: genetic and functional characterisation. therapeutic application,unassigned 1,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103041&form=6&db=m Association of the New Variant Tyr424Asp at TBK1 Gene with Amyotrophic Lateral Sclerosis and Cognitive Decline. therapeutic application,unassigned 1,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29137817&form=6&db=m Beyond ALS and FTD: the phenotypic spectrum of TBK1 mutations includes PSP-like and cerebellar phenotypes. unassigned - 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29146049&form=6&db=m Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort. causal interaction,unassigned 4,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30193106&form=6&db=m Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1. therapeutic application,unassigned 1,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30534373&form=6&db=m Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31000212&form=6&db=m Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic ALS. unassigned - 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31160356&form=6&db=m A novel TBK1 mutation in a family with diverse frontotemporal dementia spectrum disorders. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32413959&form=6&db=m UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway. unassigned - 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835772&form=6&db=m ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation. unassigned - 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33005894&form=6&db=m Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. unassigned - 2.7.11.10 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34057020&form=6&db=m Autophagy and ALS: mechanistic insights and therapeutic implications. therapeutic application,unassigned 1,0 2.7.11.10 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18692471&form=6&db=m Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. ongoing research,unassigned 2,0 2.7.11.10 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19620708&form=6&db=m Anthrax lethal toxin enhances IkappaB kinase activation and differentially regulates pro-inflammatory genes in human endothelium. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9811891&form=6&db=m NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11508443&form=6&db=m Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252035&form=6&db=m The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. therapeutic application,unassigned 3,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846333&form=6&db=m Amelioration of Arthritis by Intraarticular Dominant Negative IKKbeta Gene Therapy Using Adeno-Associated Virus Type 5. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16942442&form=6&db=m Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17009244&form=6&db=m IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17195214&form=6&db=m Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18653628&form=6&db=m Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19652024&form=6&db=m Periodic, Partial Inhibition of IKK{beta}-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30009417&form=6&db=m Therapeutic effects of a TBK1 kinase inhibitor in germinal center-driven, autoantibody-mediated inflammatory arthritis. therapeutic application,unassigned 4,0 2.7.11.10 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316093&form=6&db=m Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16009742&form=6&db=m Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16684367&form=6&db=m Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846333&form=6&db=m Amelioration of Arthritis by Intraarticular Dominant Negative IKKbeta Gene Therapy Using Adeno-Associated Virus Type 5. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16942442&form=6&db=m Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19652024&form=6&db=m Periodic, Partial Inhibition of IKK{beta}-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10072544&form=6&db=m Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent. ongoing research,unassigned 1,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11508443&form=6&db=m Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11902829&form=6&db=m Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12847684&form=6&db=m Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316093&form=6&db=m Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17009244&form=6&db=m IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17067557&form=6&db=m Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IkappaB kinase. diagnostic usage,unassigned 2,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284228&form=6&db=m IkappaBalpha promoter polymorphisms in patients with rheumatoid arthritis. causal interaction,diagnostic usage,unassigned 3,4,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17328045&form=6&db=m Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080359&form=6&db=m Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20563630&form=6&db=m Inhibitor IkappaBalpha promoter functional polymorphisms in patients with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15573863&form=6&db=m Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16157044&form=6&db=m Adenovirus-mediated overexpression of novel mutated IkappaBalpha inhibits nuclear factor kappaB activation in endothelial cells. causal interaction,unassigned 4,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16874300&form=6&db=m The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178007&form=6&db=m Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18070230&form=6&db=m Selective blockade of NF-kappaB by novel mutated IkappaBalpha suppresses CD3/CD28-induced activation of memory CD4+ T cells in asthma. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19180958&form=6&db=m [Studies on the effect of Ginkgo biloba extracts on NF-kappaB pathway] therapeutic application,unassigned 1,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20573155&form=6&db=m IkappaB kinase beta inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21236687&form=6&db=m Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25905622&form=6&db=m Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31697998&form=6&db=m Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice. therapeutic application,unassigned 4,0 2.7.11.10 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005399&form=6&db=m Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.10 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12927200&form=6&db=m Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol. unassigned - 2.7.11.10 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18182058&form=6&db=m Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques. unassigned - 2.7.11.10 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292187&form=6&db=m Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage. unassigned - 2.7.11.10 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497931&form=6&db=m Molecular Linkage Between the Kinase ATM and NF-{kappa}B Signaling in Response to Genotoxic Stimuli. therapeutic application,unassigned 1,0 2.7.11.10 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17700524&form=6&db=m ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33230792&form=6&db=m Nickel carcinogenesis mechanism: cell cycle dysregulation. therapeutic application,unassigned 1,0 2.7.11.10 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561702&form=6&db=m Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. ongoing research,unassigned 2,0 2.7.11.10 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064395&form=6&db=m Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15617879&form=6&db=m Potential utility of natural polyphenols for reversing fat-induced insulin resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15619605&form=6&db=m Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823272&form=6&db=m Inhibition of cytokine-induced IkappaB kinase activation as a mechanism contributing to the anti-atherogenic activity of tilianin in hyperlipidemic mice. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294940&form=6&db=m A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.10 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19285872&form=6&db=m IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33724136&form=6&db=m Recent progress in small molecule TBK1 inhibitors: a patent review (2015- 2020). causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34051368&form=6&db=m TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery. therapeutic application,unassigned 1,0 2.7.11.10 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9819420&form=6&db=m Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657141&form=6&db=m Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor. unassigned - 2.7.11.10 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17335348&form=6&db=m TBK1 protects vacuolar integrity during intracellular bacterial infection. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18432192&form=6&db=m NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18678662&form=6&db=m Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. unassigned - 2.7.11.10 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20360934&form=6&db=m Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma. unassigned - 2.7.11.10 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16239395&form=6&db=m IKK{beta} as a target for treatment of inflammation induced bone loss. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17966397&form=6&db=m Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364447&form=6&db=m alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891791&form=6&db=m NF-kappaB and IkappaBalpha expression following traumatic brain injury to the immature rat brain. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.10 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12676069&form=6&db=m Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia. unassigned - 2.7.11.10 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627497&form=6&db=m Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in rats. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829915&form=6&db=m Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.10 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20125184&form=6&db=m Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9848280&form=6&db=m IkappaBalpha degradation is not a requirement for the X-ray-induced activation of nuclear factor kappaB in normal rat astrocytes and human brain tumour cells. unassigned - 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10373501&form=6&db=m Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10962577&form=6&db=m Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11325857&form=6&db=m Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752211&form=6&db=m IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534291&form=6&db=m Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084260&form=6&db=m IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. causal interaction,unassigned 3,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15808510&form=6&db=m Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. causal interaction,unassigned 3,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833852&form=6&db=m Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856005&form=6&db=m The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells. unassigned - 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16194364&form=6&db=m [The nuclear factor kappa B activation: the key step of cell proliferation in estrogen receptor-negative breast cancer cells] unassigned - 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243823&form=6&db=m Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357145&form=6&db=m Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397257&form=6&db=m A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16408291&form=6&db=m Targeting the NF-kappaB pathway in estrogen receptor negative MDA-MB-231 breast cancer cells using small inhibitory RNAs. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16908599&form=6&db=m Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. therapeutic application,unassigned 2,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574017&form=6&db=m All roads lead to IKKepsilon. unassigned - 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574021&form=6&db=m Integrative genomic approaches identify IKBKE as a breast cancer oncogene. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693255&form=6&db=m IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. causal interaction,unassigned 4,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890319&form=6&db=m IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18386159&form=6&db=m Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway. unassigned - 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18483177&form=6&db=m Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18702457&form=6&db=m Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060926&form=6&db=m Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19204936&form=6&db=m Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis. ongoing research,unassigned 1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19349372&form=6&db=m Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19481526&form=6&db=m Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. causal interaction,unassigned 3,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19526344&form=6&db=m Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKbeta. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19766100&form=6&db=m TNFalpha induces HIF-1alpha expression through activation of IKKbeta. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19838210&form=6&db=m Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. unassigned - 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940156&form=6&db=m IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946332&form=6&db=m Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188669&form=6&db=m SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20671747&form=6&db=m Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-kappaB noncanonical and canonical pathway activation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21383699&form=6&db=m Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-?B: implication in breast cancer metastasis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24449872&form=6&db=m Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24487029&form=6&db=m shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29158506&form=6&db=m The IKK/NF-?B signaling pathway requires Morgana to drive breast cancer metastasis. ongoing research,unassigned 3,0 2.7.11.10 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33148660&form=6&db=m ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth. ongoing research,unassigned 1,0 2.7.11.10 Bronchitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25151727&form=6&db=m [Mangiferin protects rats against chronic bronchitis via regulating NF-kappaB (P65) and IkappaBalpha expression in mononuclear cells]. ongoing research,unassigned 3,0 2.7.11.10 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16464740&form=6&db=m Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappaB inhibitory proteins IkappaBalpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells. ongoing research,unassigned 3,0 2.7.11.10 calpain-3 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11485017&form=6&db=m Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights into the IkappaBalpha/NF-kappaB survival pathway in skeletal muscle. unassigned - 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12226754&form=6&db=m The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084260&form=6&db=m IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. causal interaction,unassigned 3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294155&form=6&db=m IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15989949&form=6&db=m IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16050135&form=6&db=m Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178184&form=6&db=m [Expression of nuclear transcription factor kappaB in hamster buccal pouch carcinogenesis] causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319058&form=6&db=m Binding of manumycin A inhibits IkappaB kinase beta activity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16555977&form=6&db=m Role of IkappaB kinase in tumorigenesis. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016640&form=6&db=m Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079494&form=6&db=m A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17278100&form=6&db=m A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines. unassigned - 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890319&form=6&db=m IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909021&form=6&db=m Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18282612&form=6&db=m Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90. causal interaction,unassigned 4,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691550&form=6&db=m Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. ongoing research,unassigned 4,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18818691&form=6&db=m IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. causal interaction,unassigned 3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19085841&form=6&db=m Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19202066&form=6&db=m Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. unassigned - 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19481526&form=6&db=m Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. causal interaction,unassigned 3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19557302&form=6&db=m Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664134&form=6&db=m Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19818716&form=6&db=m KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851710&form=6&db=m Eugenol inhibits cell proliferation via NF-kappaB suppression in a rat model of gastric carcinogenesis induced by MNNG. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227042&form=6&db=m Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304950&form=6&db=m Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. causal interaction,unassigned 3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20347815&form=6&db=m Inhibitor of kappaB Kinase Beta Regulates Gastric Carcinogenesis via Interleukin-1alpha Expression. causal interaction,unassigned 4,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20584749&form=6&db=m Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target. causal interaction,unassigned 3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29218456&form=6&db=m Assessment of TANK-binding kinase 1 as a therapeutic target in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33808757&form=6&db=m Attribution of NF-?B Activity to CHUK/IKK?-Involved Carcinogenesis. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34111484&form=6&db=m A review on the role of TANK-binding kinase 1 signaling in cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8824277&form=6&db=m Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. therapeutic application,unassigned 1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694722&form=6&db=m Impaired activation of NFkappaB in T cells from a subset of renal cell carcinoma patients is mediated by inhibition of phosphorylation and degradation of the inhibitor, IkappaBalpha. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9879995&form=6&db=m Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10416612&form=6&db=m Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. causal interaction,unassigned 4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520600&form=6&db=m Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11600145&form=6&db=m Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells. ongoing research,unassigned 4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11691793&form=6&db=m Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells. therapeutic application,unassigned 1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11753981&form=6&db=m High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706343&form=6&db=m Adriamycin activates NF-kappaB in human lung carcinoma cells by IkappaBalpha degradation. ongoing research,unassigned 4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12807725&form=6&db=m Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. causal interaction,unassigned 1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824895&form=6&db=m Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256475&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476283&form=6&db=m Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492250&form=6&db=m Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979384&form=6&db=m Effects of IkappaB kinase alpha on the differentiation of squamous carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16827119&form=6&db=m Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079494&form=6&db=m A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17643371&form=6&db=m IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785555&form=6&db=m Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786306&form=6&db=m Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells. therapeutic application,unassigned 1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909021&form=6&db=m Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18163448&form=6&db=m The ubiquitin-proteasome pathway and enhanced activity of NF-kappaB in gastric carcinoma. causal interaction,unassigned 3,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18268325&form=6&db=m IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. unassigned - 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18604171&form=6&db=m IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18702457&form=6&db=m Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772111&form=6&db=m IKKalpha is required to maintain skin homeostasis and prevent skin cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18830563&form=6&db=m The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression. ongoing research,unassigned 4,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957551&form=6&db=m The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19085841&form=6&db=m Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20001340&form=6&db=m NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304950&form=6&db=m Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. causal interaction,unassigned 3,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501320&form=6&db=m Aberrant expression of interferon regulatory factor 3 in human lung cancer. diagnostic usage,unassigned 3,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546338&form=6&db=m Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753359&form=6&db=m Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30912981&form=6&db=m TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells. causal interaction,unassigned 3,0 2.7.11.10 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664134&form=6&db=m Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10692445&form=6&db=m NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059688&form=6&db=m IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418646&form=6&db=m TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. ongoing research,unassigned 3,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11431731&form=6&db=m Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice. ongoing research,unassigned 2,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14572641&form=6&db=m Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells. ongoing research,unassigned 2,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14647065&form=6&db=m Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes. ongoing research,unassigned 4,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466196&form=6&db=m Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319058&form=6&db=m Binding of manumycin A inhibits IkappaB kinase beta activity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733806&form=6&db=m Bortezomib induces in HepG2 cells IkappaBalpha degradation mediated by caspase-8. causal interaction,unassigned 3,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17446166&form=6&db=m Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18359703&form=6&db=m [Enhancement of HepG2 cell radiosensitivity by mutant IkappaBalpha gene transfection.] ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074436&form=6&db=m Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB. ongoing research,unassigned 1,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19635861&form=6&db=m Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage. causal interaction,diagnostic usage,unassigned 1,1,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19728335&form=6&db=m High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754144&form=6&db=m Freeze-dried grape powder attenuates mitochondria- and oxidative stress-mediated apoptosis in liver cells. diagnostic usage,unassigned 3,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22590978&form=6&db=m The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells. ongoing research,unassigned 3,0 2.7.11.10 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33679751&form=6&db=m TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.7.11.10 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12807725&form=6&db=m Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. causal interaction,unassigned 1,0 2.7.11.10 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256475&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16827119&form=6&db=m Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.10 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19500386&form=6&db=m Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.10 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694722&form=6&db=m Impaired activation of NFkappaB in T cells from a subset of renal cell carcinoma patients is mediated by inhibition of phosphorylation and degradation of the inhibitor, IkappaBalpha. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10416612&form=6&db=m Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. causal interaction,unassigned 4,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11753981&form=6&db=m High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827262&form=6&db=m Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492250&form=6&db=m Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979384&form=6&db=m Effects of IkappaB kinase alpha on the differentiation of squamous carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079494&form=6&db=m A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17643371&form=6&db=m IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909021&form=6&db=m Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18268325&form=6&db=m IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. unassigned - 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18604171&form=6&db=m IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957551&form=6&db=m The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19085841&form=6&db=m Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20001340&form=6&db=m NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304950&form=6&db=m Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. causal interaction,unassigned 3,0 2.7.11.10 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501320&form=6&db=m Aberrant expression of interferon regulatory factor 3 in human lung cancer. diagnostic usage,unassigned 3,0 2.7.11.10 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671767&form=6&db=m Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27249321&form=6&db=m Suppressor of IKK? is an essential negative regulator of pathological cardiac hypertrophy. therapeutic application,unassigned 1,0 2.7.11.10 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29793309&form=6&db=m Astragaloside IV protects against the pathological cardiac hypertrophy in mice. therapeutic application,unassigned 1,0 2.7.11.10 Chlamydia Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17301240&form=6&db=m Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia. therapeutic application,unassigned 1,0 2.7.11.10 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10990217&form=6&db=m Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632959&form=6&db=m The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.10 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30541955&form=6&db=m Classical swine fever virus non-structural protein 4B binds tank-binding kinase 1. therapeutic application,unassigned 1,0 2.7.11.10 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403828&form=6&db=m Functional characterization of a purified, recombinant NF-kappaB/IkappaB complex. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10756005&form=6&db=m Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB. unassigned - 2.7.11.10 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467309&form=6&db=m Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways. ongoing research,unassigned 2,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991079&form=6&db=m An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818780&form=6&db=m Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17119390&form=6&db=m Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17709478&form=6&db=m Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18025231&form=6&db=m Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. ongoing research,unassigned 1,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815378&form=6&db=m Opposing functions of IKKbeta during acute and chronic intestinal inflammation. causal interaction,unassigned 4,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19528876&form=6&db=m Nuclear factor-kappa B in intestinal protection and destruction. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31107556&form=6&db=m Attenuation of NF-?B in Intestinal Epithelial Cells Is Sufficient to Mitigate the Bone Loss Comorbidity of Experimental Mouse Colitis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.10 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753535&form=6&db=m Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis. causal interaction,unassigned 3,0 2.7.11.10 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17124531&form=6&db=m Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. therapeutic application,unassigned 1,0 2.7.11.10 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18973019&form=6&db=m [Effect of Kuijieling decoction on proteins expression of IKK-alpha in colonic mucosa of ulcerative colitis model rats] diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.10 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294155&form=6&db=m IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19557302&form=6&db=m Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10480951&form=6&db=m Sulindac inhibits activation of the NF-kappaB pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10784420&form=6&db=m Activation of NF-kappaB determines the sensitivity of human colon cancer cells to TNFalpha-induced apoptosis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172114&form=6&db=m Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15352034&form=6&db=m The tumor-suppressive reagent taurolidine is an inhibitor of protein biosynthesis. therapeutic application,unassigned 3,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15706420&form=6&db=m Mapping of the critical region of mitogene-inducible gene-6 for NF-kappaB activation. unassigned - 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16774932&form=6&db=m Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288389&form=6&db=m A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19172851&form=6&db=m Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19778522&form=6&db=m Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21258194&form=6&db=m [The role of NF-kappaB in colon cancer]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10811101&form=6&db=m Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation. diagnostic usage,therapeutic application,unassigned 3,4,0 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912124&form=6&db=m Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771929&form=6&db=m Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059344&form=6&db=m The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB. therapeutic application,unassigned 1,0 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19172851&form=6&db=m Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513071&form=6&db=m Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19786027&form=6&db=m Prolyl Hydroxylase-3 Is Downregulated in Colorectal Cancer Cells and Inhibits IKKbeta, Independent of Hydroxylase Activity. diagnostic usage,unassigned 3,0 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20027638&form=6&db=m Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma. unassigned - 2.7.11.10 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207641&form=6&db=m A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase ? in colorectal cancer unassigned - 2.7.11.10 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340762&form=6&db=m Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells. ongoing research,unassigned 1,0 2.7.11.10 Corneal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676628&form=6&db=m Inhibition by a selective IkappaB kinase-2 inhibitor of interleukin-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829431&form=6&db=m Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha. causal interaction,unassigned 4,0 2.7.11.10 Cowpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11543670&form=6&db=m Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Cowpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596385&form=6&db=m Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517905&form=6&db=m Cell specific effects of glucocorticoid treatment on the NF-kappaBp65/IkappaBalpha system in patients with Crohn's disease. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.10 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17124531&form=6&db=m Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. therapeutic application,unassigned 1,0 2.7.11.10 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10694811&form=6&db=m Anti-inflammatory gene therapy directed at the airway epithelium. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.10 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706733&form=6&db=m High susceptibility for cystic fibrosis human airway gland cells to produce IL-8 through the I kappa B kinase alpha pathway in response to extracellular NaCl content. ongoing research,unassigned 2,0 2.7.11.10 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12762338&form=6&db=m Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-beta kinase pathway. ongoing research,unassigned 2,0 2.7.11.10 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17272824&form=6&db=m Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.10 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570907&form=6&db=m [A Pair of Siblings with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and a Novel Thr462Lysfs Mutation in the TBK1 Gene]. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008748&form=6&db=m TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. ongoing research,unassigned 2,0 2.7.11.10 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30549411&form=6&db=m Gene mutations in a Han Chinese Alzheimer's disease cohort. causal interaction,unassigned 2,0 2.7.11.10 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848189&form=6&db=m Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila. causal interaction,unassigned 3,0 2.7.11.10 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8628301&form=6&db=m IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200541&form=6&db=m IKKbeta Leads to an Inflammatory Skin Disease Resembling Interface Dermatitis. therapeutic application,unassigned 2,0 2.7.11.10 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533494&form=6&db=m Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12021247&form=6&db=m Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723063&form=6&db=m Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. ongoing research,unassigned 3,0 2.7.11.10 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17267600&form=6&db=m NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. ongoing research,unassigned 4,0 2.7.11.10 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30349097&form=6&db=m Inhibition of TBK1/IKK? Promotes Regeneration of Pancreatic ?-cells. unassigned - 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489937&form=6&db=m Prevention of fat-induced insulin resistance by salicylate. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533494&form=6&db=m Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11932336&form=6&db=m Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. ongoing research,therapeutic application,unassigned 3,2,0 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12021247&form=6&db=m Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15617879&form=6&db=m Potential utility of natural polyphenols for reversing fat-induced insulin resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505240&form=6&db=m Reduced Skeletal Muscle Inhibitor of {kappa}B{beta} Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training. causal interaction,unassigned 3,0 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940218&form=6&db=m Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363130&form=6&db=m Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062574&form=6&db=m Down syndrome candidate region 1 increases the stability of the IkappaBalpha protein: implications for its anti-inflammatory effects. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.10 Dysautonomia, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11722848&form=6&db=m Genomic organization and chromosomal localization of the mouse IKBKAP gene. causal interaction,unassigned 4,0 2.7.11.10 Dysautonomia, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12788105&form=6&db=m Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia. causal interaction,unassigned 3,0 2.7.11.10 Dysautonomia, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15797185&form=6&db=m Episodic somnolence in an infant with Riley-Day syndrome. causal interaction,unassigned 3,0 2.7.11.10 Dysautonomia, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17605759&form=6&db=m Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Dysautonomia, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18091349&form=6&db=m IKBKAP mRNA in peripheral blood leukocytes: a molecular marker of gene expression and splicing in familial dysautonomia. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Dysautonomia, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19429107&form=6&db=m ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells. causal interaction,unassigned 3,0 2.7.11.10 Dysautonomia, Familial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821670&form=6&db=m Specific correction of a splice defect in brain by nutritional supplementation. causal interaction,unassigned 2,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12651765&form=6&db=m Anhidrotic ectodermal dysplasia and immunodeficiency: the role of NEMO. causal interaction,unassigned 2,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14523047&form=6&db=m A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. causal interaction,unassigned 2,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734108&form=6&db=m Inherited disorders of NF-kappaB-mediated immunity in man. causal interaction,unassigned 3,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604887&form=6&db=m Autosomal-dominant primary immunodeficiencies. therapeutic application,unassigned 1,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17931563&form=6&db=m Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. causal interaction,unassigned 4,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18633439&form=6&db=m IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080849&form=6&db=m Growth hormone and insulin-like growth factor I insensitivity of fibroblasts isolated from a patient with an I{kappa}B{alpha} mutation. causal interaction,unassigned 4,0 2.7.11.10 Ectodermal Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20542322&form=6&db=m Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. causal interaction,unassigned 2,0 2.7.11.10 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364447&form=6&db=m alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007573&form=6&db=m Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007573&form=6&db=m Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23091891&form=6&db=m Expression of inflammatory cytokines by adipose tissue from patients with endometrial cancer. ongoing research,unassigned 3,0 2.7.11.10 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19129371&form=6&db=m Nuclear factor kappaB pathway and interleukin-6 are affected in eutopic endometrium of women with endometriosis. ongoing research,unassigned 3,0 2.7.11.10 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20797350&form=6&db=m Immunohistochemical study of the ubiquitin-nuclear factor-kB pathway in the endometrium of the baboon (Papio anubis) with and without endometriosis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9276714&form=6&db=m Role of NFkappaB in the mortality of sepsis. ongoing research,unassigned 4,0 2.7.11.10 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10467251&form=6&db=m Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.7.11.10 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16919832&form=6&db=m 4-O-Methylgallic acid suppresses inflammation-associated gene expression by inhibition of redox-based NF-kappaB activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.7.11.10 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935850&form=6&db=m Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.10 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121777&form=6&db=m [Sophoridine inhibits NF-kappaB signaling pathway activation in kidney tissue of endotoxemia mice]. causal interaction,unassigned 2,0 2.7.11.10 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002568&form=6&db=m Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.10 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178007&form=6&db=m Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.10 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16919057&form=6&db=m NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks. ongoing research,unassigned 4,0 2.7.11.10 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806421&form=6&db=m IkappaB kinase 2 inhibition corrects defective nitrergic erectile mechanisms in diabetic mouse corpus cavernosum. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Escherichia coli Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15270851&form=6&db=m Escherichia coli up-regulates proinflammatory cytokine expression in granulocyte/macrophage lineages of CD34 stem cells via p50 homodimeric NF-kappaB. unassigned - 2.7.11.10 Escherichia coli Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15932506&form=6&db=m Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF-kappaB signal transduction pathway in astrocytes infected with Escherichia coli. ongoing research,unassigned 2,0 2.7.11.10 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337965&form=6&db=m Enhanced sensitivity to chemotherapy in esophageal cancer through inhibition of NF-kappaB. therapeutic application,unassigned 2,0 2.7.11.10 Exanthema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071880&form=6&db=m I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.10 Eye Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444978&form=6&db=m An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406439&form=6&db=m Animal models of steatohepatitis. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.10 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18644995&form=6&db=m Active roles for inhibitory kappaB kinases alpha and beta in nuclear factor-kappaB-mediated chemoresistance to doxorubicin. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.10 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20473944&form=6&db=m Lymphotoxin-beta receptor activation by lymphotoxin-alpha(1)beta(2) and LIGHT promotes tumor growth in an NFkappaB-dependent manner. unassigned - 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27156075&form=6&db=m TBK1 is associated with ALS and ALS-FTD in Sardinian patients. therapeutic application,unassigned 1,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570907&form=6&db=m [A Pair of Siblings with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and a Novel Thr462Lysfs Mutation in the TBK1 Gene]. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008748&form=6&db=m TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. ongoing research,unassigned 2,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28229125&form=6&db=m The clinical, neuroanatomical, and neuropathologic phenotype of TBK1-associated frontotemporal dementia: A longitudinal case report. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29137817&form=6&db=m Beyond ALS and FTD: the phenotypic spectrum of TBK1 mutations includes PSP-like and cerebellar phenotypes. unassigned - 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29146049&form=6&db=m Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort. causal interaction,unassigned 4,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30193106&form=6&db=m Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1. therapeutic application,unassigned 1,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30534373&form=6&db=m Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672142&form=6&db=m Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31160356&form=6&db=m A novel TBK1 mutation in a family with diverse frontotemporal dementia spectrum disorders. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32980182&form=6&db=m Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing primary progressive aphasia and review of the literature. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33005894&form=6&db=m Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. unassigned - 2.7.11.10 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34057020&form=6&db=m Autophagy and ALS: mechanistic insights and therapeutic implications. therapeutic application,unassigned 1,0 2.7.11.10 Frontotemporal Lobar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32835772&form=6&db=m ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation. unassigned - 2.7.11.10 Frontotemporal Lobar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33044112&form=6&db=m SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation. diagnostic usage,unassigned 3,0 2.7.11.10 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495515&form=6&db=m Helicobacter pylori Induces I{kappa}B Kinase {alpha} Nuclear Translocation and Chemokine Production in Gastric Epithelial Cells. causal interaction,unassigned 2,0 2.7.11.10 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18070894&form=6&db=m Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils. causal interaction,unassigned 4,0 2.7.11.10 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12788105&form=6&db=m Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia. causal interaction,unassigned 3,0 2.7.11.10 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19429107&form=6&db=m ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells. causal interaction,unassigned 3,0 2.7.11.10 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19816602&form=6&db=m Suppression of IkappaBalpha increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28025332&form=6&db=m Transgenic TBK1 mice have features of normal tension glaucoma. causal interaction,unassigned 1,0 2.7.11.10 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28984711&form=6&db=m Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients. unassigned - 2.7.11.10 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6297726&form=6&db=m Multiple forms of protein kinase from normal human brain and glioblastoma. ongoing research,unassigned 3,0 2.7.11.10 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15692608&form=6&db=m Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.10 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19187648&form=6&db=m The regulating role of mutant IkappaBalpha in expression of TIMP-2 and MMP-9 in human glioblastoma multiform. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.10 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725919&form=6&db=m Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6244301&form=6&db=m Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells. unassigned - 2.7.11.10 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336492&form=6&db=m Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB linked to chemokine production. unassigned - 2.7.11.10 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364447&form=6&db=m alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10744043&form=6&db=m Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. ongoing research,therapeutic application,unassigned 4,2,0 2.7.11.10 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12675310&form=6&db=m Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.10 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010209&form=6&db=m Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB. causal interaction,unassigned 1,0 2.7.11.10 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16050135&form=6&db=m Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Glomerulosclerosis, Focal Segmental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11045652&form=6&db=m Increased nuclear factor-kappaB and angiotensinogen gene expression in posttransplant recurrent focal segmental glomerulosclerosis. ongoing research,unassigned 3,0 2.7.11.10 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854155&form=6&db=m Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. causal interaction,unassigned 2,0 2.7.11.10 Granulosa Cell Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23674259&form=6&db=m Characterization of the Inhibitor of KappaB Kinase (IKK) Complex in Granulosa Cell Tumors of the Ovary and Granulosa Cell Tumor-Derived Cell Lines. ongoing research,unassigned 4,0 2.7.11.10 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821700&form=6&db=m Curcumin Treatment Suppresses IKK{beta} Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3 2.7.11.10 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17072330&form=6&db=m Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. causal interaction,unassigned 3,0 2.7.11.10 Hemorrhagic Fevers, Viral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25780281&form=6&db=m Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system. unassigned - 2.7.11.10 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10692445&form=6&db=m NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.10 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919917&form=6&db=m Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.10 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454581&form=6&db=m Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12634363&form=6&db=m Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid Integrity through activation of NF-kappaB. causal interaction,unassigned 1,0 2.7.11.10 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19797428&form=6&db=m IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24180280&form=6&db=m Stimulation of DDX3 expression by ginsenoside Rg3 through the Akt/p53 pathway activates the innate immune response via TBK1/IKK?/IRF3 signalling. unassigned - 2.7.11.10 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12909638&form=6&db=m Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767399&form=6&db=m Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.10 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919917&form=6&db=m Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.10 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16581780&form=6&db=m Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.10 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20594262&form=6&db=m Hepatitis C virus core protein induces malignant transformation of biliary epithelial cells by activating nuclear factor-kappaB pathway. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.10 Hepatitis E http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22590978&form=6&db=m The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells. ongoing research,unassigned 3,0 2.7.11.10 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530405&form=6&db=m Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15692608&form=6&db=m Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.10 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407234&form=6&db=m Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes. ongoing research,unassigned 3,0 2.7.11.10 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18539148&form=6&db=m HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29743370&form=6&db=m Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex. therapeutic application,unassigned 1,0 2.7.11.10 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196284&form=6&db=m Ikappakappa mediates NF-kappaB activation in human immunodeficiency virus-infected cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.10 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15270850&form=6&db=m Disruption of MAP kinase activation and nuclear factor binding to the IL-12 p40 promoter in HIV-infected myeloid cells. therapeutic application,unassigned 2,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340377&form=6&db=m Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. causal interaction,unassigned 3,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556199&form=6&db=m Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10637284&form=6&db=m Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858823&form=6&db=m Germline mutations and polymorphisms in the NFKBIA gene in Hodgkin lymphoma. therapeutic application,unassigned 1,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16185501&form=6&db=m [Preliminary analysis of mutations in exon 5 of IkappaBalpha gene in Hodgkin lymphoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299251&form=6&db=m Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17119127&form=6&db=m Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. unassigned - 2.7.11.10 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19648161&form=6&db=m Mutations in the genes coding for the NF-{kappa}B regulating factors I{kappa}B{alpha} and A20 are uncommon in nodular lymphocyte-predominant Hodgkin lymphoma. unassigned - 2.7.11.10 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973242&form=6&db=m Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.10 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25997745&form=6&db=m TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-?B dependent genes. causal interaction,unassigned 2,0 2.7.11.10 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081881&form=6&db=m Diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type dependent manner. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.10 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786306&form=6&db=m Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells. therapeutic application,unassigned 1,0 2.7.11.10 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696914&form=6&db=m Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12615800&form=6&db=m Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock. unassigned - 2.7.11.10 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16680015&form=6&db=m Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.7.11.10 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18555988&form=6&db=m Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock. therapeutic application,unassigned 1,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8628301&form=6&db=m IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11845301&form=6&db=m Relationship between IkappaBalpha deficiency, NFkappaB activity and interleukin-8 production in CF human airway epithelial cells. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633691&form=6&db=m Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15721278&form=6&db=m Inhibition of NF-kappaB stabilizes gadd45alpha mRNA. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16283526&form=6&db=m Deficiency in Ikkbeta gene enhances arsenic-induced gadd45alpha expression. causal interaction,ongoing research,unassigned 2,3,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640307&form=6&db=m Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18432192&form=6&db=m NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18653628&form=6&db=m Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 2.7.11.10 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815378&form=6&db=m Opposing functions of IKKbeta during acute and chronic intestinal inflammation. causal interaction,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=170098&form=6&db=m Protein kinase of bacteriophage T7. 1. Purification. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1101258&form=6&db=m In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8764027&form=6&db=m Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256493&form=6&db=m Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9573251&form=6&db=m The major component of IkappaBalpha proteolysis occurs independently of the proteasome pathway in respiratory syncytial virus-infected pulmonary epithelial cells. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9621019&form=6&db=m Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, underphosphorylated IkappaBbeta, and sequestration of protein phosphatase 2A by the viral phosphoprotein. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022529&form=6&db=m Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196356&form=6&db=m Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10415047&form=6&db=m NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10692445&form=6&db=m NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10889159&form=6&db=m H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells. diagnostic usage,unassigned 3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10967112&form=6&db=m Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor. ongoing research,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11147598&form=6&db=m Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma. causal interaction,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312255&form=6&db=m Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. therapeutic application,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11337506&form=6&db=m Activation of NF-kappa B via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483745&form=6&db=m Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11543670&form=6&db=m Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11555675&form=6&db=m Specific deficiency in nuclear factor-kappaB activation in neurons of the central nervous system. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11582519&form=6&db=m Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739238&form=6&db=m Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11773980&form=6&db=m Simultaneous inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFalpha-mediated apoptosis. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11815436&form=6&db=m Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. ongoing research,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12050393&form=6&db=m Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells. ongoing research,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068072&form=6&db=m Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes. ongoing research,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12106602&form=6&db=m Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12219002&form=6&db=m Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death. therapeutic application,unassigned 3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432072&form=6&db=m Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion. therapeutic application,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12574341&form=6&db=m NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12672819&form=6&db=m The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12805425&form=6&db=m NF-kappaB is required for apoptosis prevention during herpes simplex virus type 1 infection. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824895&form=6&db=m Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839879&form=6&db=m Enhancement of lipopolysaccharide-stimulated JNK activity in rat aortic smooth muscle cells by pharmacological and adenovirus-mediated inhibition of inhibitory kappa B kinase signalling. diagnostic usage,therapeutic application,unassigned 3,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12919943&form=6&db=m Helicobacter pylori infection activates NF-kappaB signaling pathway to induce iNOS and protect human gastric epithelial cells from apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14963119&form=6&db=m IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977954&form=6&db=m Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14990741&form=6&db=m Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15078930&form=6&db=m Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter. diagnostic usage,therapeutic application,unassigned 1,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15270851&form=6&db=m Escherichia coli up-regulates proinflammatory cytokine expression in granulocyte/macrophage lineages of CD34 stem cells via p50 homodimeric NF-kappaB. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322192&form=6&db=m Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. therapeutic application,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15367631&form=6&db=m Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492272&form=6&db=m Human polynucleotide phosphorylase (hPNPaseold-35): a potential link between aging and inflammation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15564469&form=6&db=m Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway. ongoing research,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604887&form=6&db=m Autosomal-dominant primary immunodeficiencies. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15618150&form=6&db=m NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15619605&form=6&db=m Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743772&form=6&db=m Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15908447&form=6&db=m Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. ongoing research,unassigned 3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15932506&form=6&db=m Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF-kappaB signal transduction pathway in astrocytes infected with Escherichia coli. ongoing research,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15997236&form=6&db=m Selective inhibition of inhibitory kappa B kinase-beta abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16007176&form=6&db=m Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. diagnostic usage,therapeutic application,unassigned 3,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16129468&form=6&db=m Porcine arterivirus activates the NF-kappaB pathway through IkappaB degradation. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16154149&form=6&db=m Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16175180&form=6&db=m NF-kappaB: linking inflammation and immunity to cancer development and progression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339966&form=6&db=m Host and parasite-derived IKK activities direct distinct temporal phases of NF-{kappa}B activation and target gene expression following Toxoplasma gondii infection. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495515&form=6&db=m Helicobacter pylori Induces I{kappa}B Kinase {alpha} Nuclear Translocation and Chemokine Production in Gastric Epithelial Cells. causal interaction,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16698992&form=6&db=m Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo. causal interaction,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806387&form=6&db=m Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16928747&form=6&db=m Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16989899&form=6&db=m Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells. therapeutic application,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17005676&form=6&db=m Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells. ongoing research,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17133498&form=6&db=m The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17322906&form=6&db=m Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17328045&form=6&db=m Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17339845&form=6&db=m Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells. ongoing research,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17371256&form=6&db=m Control of the NF-kappaB inhibitor IkappaBalpha in pathogen infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17419715&form=6&db=m Activation of the virus-induced IKK/NF-kappaB signalling axis is critical for the replication of human cytomegalovirus in quiescent cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17435549&form=6&db=m Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expression. therapeutic application,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653813&form=6&db=m Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17659437&form=6&db=m Apoptosis of dedifferentiated hepatoma cells is independent of NF-kappaB activation in response to LPS. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671417&form=6&db=m Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17939994&form=6&db=m A role for I{kappa}B kinase 2 in bipolar spindle assembly. causal interaction,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18432192&form=6&db=m NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18490491&form=6&db=m An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632959&form=6&db=m The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19131335&form=6&db=m Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19180189&form=6&db=m Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638980&form=6&db=m Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851467&form=6&db=m Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein m013. therapeutic application,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19862774&form=6&db=m Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19962981&form=6&db=m Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. ongoing research,unassigned 4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20081355&form=6&db=m Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation. diagnostic usage,ongoing research,unassigned 4,3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353939&form=6&db=m Activation of non-canonical NF-{kappa}B signaling by the oncoprotein TIO. ongoing research,unassigned 3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20686657&form=6&db=m Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. therapeutic application,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20817314&form=6&db=m Molecular cloning of IKKbeta from the mandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNV infection. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23422957&form=6&db=m I kappa B kinase alpha (IKK?) activity is required for functional maturation of dendritic cells and acquired immunity to infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23463379&form=6&db=m Ca(2+) /calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155403&form=6&db=m NF-?B activation coordinated by IKK? and IKK? enables latent infection of Kaposi's sarcoma-associated herpesvirus. causal interaction,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24418622&form=6&db=m MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24586253&form=6&db=m The role of IKK? in Venezuelan equine encephalitis virus infection. ongoing research,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25082354&form=6&db=m The role of the IKK complex in viral infections. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25440083&form=6&db=m Mycoplasma ovipneumoniae induces inflammatory response in sheep airway epithelial cells via a MyD88-dependent TLR signaling pathway. causal interaction,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26283628&form=6&db=m Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-? production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26830977&form=6&db=m Bacterial Muramyl Dipeptide (MDP) Restricts Human Cytomegalovirus Replication via an IFN-?-Dependent Pathway. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29244863&form=6&db=m A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-?B signaling. causal interaction,unassigned 3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444978&form=6&db=m An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29703257&form=6&db=m InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29960062&form=6&db=m Ctenopharyngodon idella TBK1 activates innate immune response via IRF7. causal interaction,unassigned 2,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662438&form=6&db=m CRISPR/Cas9-Mediated Chicken TBK1 Gene Knockout and Its Essential Role in STING-Mediated IFN-? Induction in Chicken Cells. causal interaction,unassigned 3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31200068&form=6&db=m Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression. causal interaction,unassigned 3,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31330869&form=6&db=m Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32034138&form=6&db=m TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy. causal interaction,unassigned 1,0 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32466380&form=6&db=m The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription. unassigned - 2.7.11.10 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32933112&form=6&db=m Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKK? Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.10 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991079&form=6&db=m An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939395&form=6&db=m Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade. ongoing research,unassigned 3,0 2.7.11.10 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722660&form=6&db=m Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase. causal interaction,unassigned 2,0 2.7.11.10 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15837793&form=6&db=m The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28954889&form=6&db=m HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress. causal interaction,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489937&form=6&db=m Prevention of fat-induced insulin resistance by salicylate. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533494&form=6&db=m Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12021247&form=6&db=m Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406439&form=6&db=m Animal models of steatohepatitis. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12409308&form=6&db=m Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12540784&form=6&db=m Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14584587&form=6&db=m IRS-1 regulation in health and disease. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14704745&form=6&db=m Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. therapeutic application,unassigned 3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14755344&form=6&db=m Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. therapeutic application,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15007033&form=6&db=m Hypertension and insulin resistance are not directly related in obese dogs. causal interaction,therapeutic application,unassigned 1,3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252018&form=6&db=m Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. therapeutic application,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15351728&form=6&db=m A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. ongoing research,therapeutic application,unassigned 2,3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15617879&form=6&db=m Potential utility of natural polyphenols for reversing fat-induced insulin resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685170&form=6&db=m IKK-beta links inflammation to obesity-induced insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685173&form=6&db=m Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. ongoing research,unassigned 2,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15896290&form=6&db=m Is NF-kappaB a culprit in type 2 diabetes? therapeutic application,unassigned 3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16225464&form=6&db=m Review article: diabetes and atherosclerosis--running on a common road. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17093946&form=6&db=m Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17446166&form=6&db=m Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604977&form=6&db=m L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17951543&form=6&db=m Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18223156&form=6&db=m HSP72 protects against obesity-induced insulin resistance. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18240344&form=6&db=m Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443205&form=6&db=m siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. unassigned - 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765510&form=6&db=m Mechanism for improved insulin sensitivity after gastric bypass surgery. therapeutic application,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18949383&form=6&db=m IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. causal interaction,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19073766&form=6&db=m Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116375&form=6&db=m Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. unassigned - 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19136667&form=6&db=m Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases. therapeutic application,unassigned 4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251743&form=6&db=m TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. therapeutic application,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363130&form=6&db=m Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19569009&form=6&db=m High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity. ongoing research,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19683471&form=6&db=m Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19696185&form=6&db=m An EGFR Tyrosine-Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737522&form=6&db=m The protein kinase IKKepsilon regulates energy balance in obese mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19798070&form=6&db=m Variant in the 3' Region of the IkappaBalpha Gene Associated With Insulin Resistance in Hispanic Americans: The IRAS Family Study. ongoing research,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19800637&form=6&db=m Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080359&form=6&db=m Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20371626&form=6&db=m JNK1 and IKK{beta}: molecular links between obesity and metabolic dysfunction. causal interaction,unassigned 4,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20522023&form=6&db=m The obese healthy paradox: is inflammation the answer? causal interaction,unassigned 1,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20822024&form=6&db=m [Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet] therapeutic application,unassigned 2,0 2.7.11.10 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30767626&form=6&db=m Molecular mechanism of interactions between Chrysin and I-kappa-B kinase epsilon (IKKe)/Tank Binding Kinase-1(TBK1): Cell based assay and insilico molecular docking studies. therapeutic application,unassigned 3,0 2.7.11.10 Klatskin Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655831&form=6&db=m Effect of mutated IkappaBalpha transfection on multidrug resistance in hilar cholangiocarcinoma cell lines. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.10 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9707608&form=6&db=m Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta. therapeutic application,unassigned 1,0 2.7.11.10 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576817&form=6&db=m Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway. therapeutic application,unassigned 1,0 2.7.11.10 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155403&form=6&db=m NF-?B activation coordinated by IKK? and IKK? enables latent infection of Kaposi's sarcoma-associated herpesvirus. causal interaction,unassigned 2,0 2.7.11.10 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28420741&form=6&db=m New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection. causal interaction,unassigned 4,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336413&form=6&db=m IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1. ongoing research,unassigned 1,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364167&form=6&db=m Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma. ongoing research,unassigned 3,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10940316&form=6&db=m Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507084&form=6&db=m An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-kappaB-independent mechanism. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11582519&form=6&db=m Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11777342&form=6&db=m 1alpha,25-dihydroxyvitamin D3 stimulates phosphorylation of IkappaBalpha and synergizes with TPA to induce nuclear translocation of NFkappaB during monocytic differentiation of NB4 leukemia cells. therapeutic application,unassigned 2,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265367&form=6&db=m Inhibition of NF-kappaB by mutant IkappaBalpha enhances TNF-alpha-induced apoptosis in HL-60 cells by controlling bcl-xL expression. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15811958&form=6&db=m Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878527&form=6&db=m Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells. ongoing research,unassigned 3,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952893&form=6&db=m Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19392652&form=6&db=m Siva-1 Promotes K-48 Polyubiquitination of TRAF2 and Inhibits TCR-Mediated Activation of NF-kappaB. therapeutic application,unassigned 1,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20671747&form=6&db=m Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-kappaB noncanonical and canonical pathway activation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627374&form=6&db=m Critical roles of I?B kinase subunits in mast cell degranulation. causal interaction,unassigned 1,0 2.7.11.10 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9596659&form=6&db=m NF-kappaB transcription factors are involved in normal erythropoiesis. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.11.10 Leukemia, Hairy Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501956&form=6&db=m Variability in the degree of expression of phosphorylated IkappaBalpha in chronic lymphocytic leukemia cases with nodal involvement. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.10 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351760&form=6&db=m p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18245668&form=6&db=m IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.10 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12357358&form=6&db=m Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.10 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17043643&form=6&db=m Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia. diagnostic usage,therapeutic application,unassigned 3,2,0 2.7.11.10 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18670883&form=6&db=m Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. diagnostic usage,unassigned 3,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8676482&form=6&db=m Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins. therapeutic application,unassigned 1,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9632633&form=6&db=m The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. ongoing research,unassigned 2,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694868&form=6&db=m NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9710600&form=6&db=m Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336413&form=6&db=m IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1. ongoing research,unassigned 1,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364167&form=6&db=m Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma. ongoing research,unassigned 3,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10438454&form=6&db=m IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. therapeutic application,unassigned 1,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567421&form=6&db=m The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex. ongoing research,unassigned 3,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648602&form=6&db=m Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. unassigned - 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11064457&form=6&db=m Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. ongoing research,unassigned 2,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11726516&form=6&db=m Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. therapeutic application,unassigned 1,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12435599&form=6&db=m Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax. ongoing research,unassigned 3,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878527&form=6&db=m Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells. ongoing research,unassigned 3,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671417&form=6&db=m Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18223255&form=6&db=m In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.10 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20627395&form=6&db=m Downregulation of active IKK beta by Ro52-mediated autophagy. causal interaction,unassigned 3,0 2.7.11.10 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15153339&form=6&db=m Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. causal interaction,unassigned 1,0 2.7.11.10 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16453001&form=6&db=m Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0 2.7.11.10 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671417&form=6&db=m Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16680015&form=6&db=m Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.7.11.10 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303015&form=6&db=m Angiotensin II Activates IkappaB Kinase Phosphorylation of RelA at Ser(536) to Promote Myofibroblast Survival and Liver Fibrosis. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31821710&form=6&db=m Dual TBK1/IKK? inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice. causal interaction,unassigned 3,0 2.7.11.10 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33966599&form=6&db=m Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025521&form=6&db=m Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality. therapeutic application,unassigned 1,0 2.7.11.10 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18704119&form=6&db=m p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15989949&form=6&db=m IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.10 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18522681&form=6&db=m Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo. unassigned - 2.7.11.10 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19728335&form=6&db=m High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Low Tension Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28984711&form=6&db=m Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients. unassigned - 2.7.11.10 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19478133&form=6&db=m Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20472709&form=6&db=m Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585596&form=6&db=m Duration and Intensity of NF-{kappa}B Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16780654&form=6&db=m [Effects of nuclear factor-kappaB on ventilator induced lung biotrauma by higher tidal volume and its interaction with pro-inflammatory cytokines] causal interaction,unassigned 1,0 2.7.11.10 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855826&form=6&db=m Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10423407&form=6&db=m IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12526088&form=6&db=m Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation. therapeutic application,unassigned 3,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12725325&form=6&db=m Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816521&form=6&db=m Gene transfer of inhibitor kappaB in human lung cancer cell line NCI-H460 inhibits tumorigenesis and angiogenesis in vivo. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606063&form=6&db=m [Inhibition of NF-kappaB through IkappaBalpha transfection affects invasion of human lung cancer cell line A549] ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18636537&form=6&db=m Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells. unassigned - 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19778522&form=6&db=m Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996305&form=6&db=m Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kappaB signaling by preventing RelA acetylation in A549 lung cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406971&form=6&db=m Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23209807&form=6&db=m TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-?B signalling. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23836654&form=6&db=m Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736766&form=6&db=m Using RNA Interference in Lung Cancer Cells to Target the IKK-NF-?B Pathway. unassigned - 2.7.11.10 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988282&form=6&db=m Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.10 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071880&form=6&db=m I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.10 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571457&form=6&db=m Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Lymphadenopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11536159&form=6&db=m Inhibition of NF-kappaB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice. therapeutic application,unassigned 1,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=191831&form=6&db=m Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=193571&form=6&db=m Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line. ongoing research,unassigned 4,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9221757&form=6&db=m IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice. ongoing research,unassigned 3,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254493&form=6&db=m Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism. ongoing research,unassigned 3,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12377412&form=6&db=m Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890756&form=6&db=m KSHV vFLIP binds to IKK-gamma to activate IKK. ongoing research,unassigned 2,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15611665&form=6&db=m Protein phosphorylation as a key mechanism for the regulation of BCL-3 activity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16289774&form=6&db=m The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line. ongoing research,therapeutic application,unassigned 1,2,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17119127&form=6&db=m Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. unassigned - 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237443&form=6&db=m Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550372&form=6&db=m Interleukin-13-induced type II polarization of inflammatory macrophages is mediated through suppression of nuclear factor-kappaB and preservation of IkappaBalpha in a T cell lymphoma. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19104039&form=6&db=m Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20516126&form=6&db=m Oncogenic activation of NF-kappaB. causal interaction,unassigned 2,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20809973&form=6&db=m I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335897&form=6&db=m Characterization of TAE684 as a potent LRRK2 kinase inhibitor. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33640899&form=6&db=m TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO. unassigned - 2.7.11.10 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15198731&form=6&db=m Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma. diagnostic usage,unassigned 3,0 2.7.11.10 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15671525&form=6&db=m Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. therapeutic application,unassigned 4,0 2.7.11.10 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299251&form=6&db=m Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355202&form=6&db=m A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. diagnostic usage,unassigned 3,0 2.7.11.10 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15198731&form=6&db=m Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma. diagnostic usage,unassigned 3,0 2.7.11.10 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15671525&form=6&db=m Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. therapeutic application,unassigned 4,0 2.7.11.10 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299251&form=6&db=m Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355202&form=6&db=m A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. diagnostic usage,unassigned 3,0 2.7.11.10 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237443&form=6&db=m Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Lymphoma, Primary Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890756&form=6&db=m KSHV vFLIP binds to IKK-gamma to activate IKK. ongoing research,unassigned 2,0 2.7.11.10 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254493&form=6&db=m Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism. ongoing research,unassigned 3,0 2.7.11.10 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550372&form=6&db=m Interleukin-13-induced type II polarization of inflammatory macrophages is mediated through suppression of nuclear factor-kappaB and preservation of IkappaBalpha in a T cell lymphoma. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Lymphoma, T-Cell, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18245554&form=6&db=m Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28049150&form=6&db=m FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions. ongoing research,unassigned 1,0 2.7.11.10 Measles http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922877&form=6&db=m Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10096573&form=6&db=m Elevated constitutive IkappaB kinase activity and IkappaB-alpha phosphorylation in Hs294T melanoma cells lead to increased basal MGSA/GRO-alpha transcription. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10976534&form=6&db=m Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313369&form=6&db=m The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11406569&form=6&db=m Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16007726&form=6&db=m Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467110&form=6&db=m BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308124&form=6&db=m mda-9/Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear factor-kappaB. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409419&form=6&db=m Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18347013&form=6&db=m The lymphotoxin-beta receptor is an upstream activator of NF-kappaB-mediated transcription in melanoma cells. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18544741&form=6&db=m KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19276165&form=6&db=m Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491262&form=6&db=m N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression. ongoing research,unassigned 1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940859&form=6&db=m NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530876&form=6&db=m Conditional ablation of Ikkb inhibits melanoma tumor development in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21795596&form=6&db=m Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7. causal interaction,unassigned 2,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23846693&form=6&db=m DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA. therapeutic application,unassigned 1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26793999&form=6&db=m The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920710&form=6&db=m Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks. causal interaction,unassigned 1,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27744496&form=6&db=m The IKK?-dependent non-canonical pathway of NF-?B activation is constitutively active and modulates progression-related functions in a subset of human melanomas. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.10 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28955326&form=6&db=m Influenza A Virus PA Antagonizes Interferon-? by Interacting with Interferon Regulatory Factor 3. unassigned - 2.7.11.10 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17880897&form=6&db=m The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. unassigned - 2.7.11.10 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29146049&form=6&db=m Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort. causal interaction,unassigned 4,0 2.7.11.10 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737512&form=6&db=m IKKepsilon: a bridge between obesity and inflammation. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34051368&form=6&db=m TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery. therapeutic application,unassigned 1,0 2.7.11.10 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080359&form=6&db=m Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004764&form=6&db=m Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation. causal interaction,unassigned 2,0 2.7.11.10 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11921057&form=6&db=m Nuclear factor-kappaB as a molecular target for migraine therapy. therapeutic application,unassigned 4,0 2.7.11.10 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16919057&form=6&db=m NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks. ongoing research,unassigned 4,0 2.7.11.10 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672142&form=6&db=m Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32980182&form=6&db=m Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing primary progressive aphasia and review of the literature. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827262&form=6&db=m Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitor. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12377412&form=6&db=m Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393461&form=6&db=m Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756023&form=6&db=m Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15922723&form=6&db=m Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor-resistant (PIR) IkappaBalpha degradation in B cells. causal interaction,unassigned 2,0 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16020669&form=6&db=m Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, induces apoptosis in multiple myeloma cells in an IkappaBalpha-independent manner. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299251&form=6&db=m Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17020997&form=6&db=m MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934314&form=6&db=m Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. unassigned - 2.7.11.10 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007573&form=6&db=m Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Murine Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10429205&form=6&db=m Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects IkappaBalpha turnover. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Muscle Cramp http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19439978&form=6&db=m NF-kappaB-Dependent Induction of Cathelicidin-Related Antimicrobial Peptide in Murine Mast Cells by Lipopolysaccharide. causal interaction,unassigned 1,0 2.7.11.10 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16928772&form=6&db=m Role for IkappaBalpha, but not c-Rel, in skeletal muscle atrophy. therapeutic application,unassigned 1,0 2.7.11.10 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18827022&form=6&db=m The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336660&form=6&db=m Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. causal interaction,unassigned 1,0 2.7.11.10 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21256828&form=6&db=m Inhibition of IkappaB kinase alpha (IKK?) or IKKbeta (IKK?) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy. therapeutic application,unassigned 2,0 2.7.11.10 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843349&form=6&db=m The Proteasome Inhibitor MG132 Reduces Immobilization-Induced Skeletal Muscle Atrophy in Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Muscular Disorders, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18827022&form=6&db=m The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Muscular Dystrophies, Limb-Girdle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17215327&form=6&db=m Beta-defensin overexpression induces progressive muscle degeneration in mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.7.11.10 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17043643&form=6&db=m Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia. diagnostic usage,therapeutic application,unassigned 3,2,0 2.7.11.10 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18670883&form=6&db=m Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. diagnostic usage,unassigned 3,0 2.7.11.10 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9950856&form=6&db=m Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.10 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179072&form=6&db=m Early activation of IKKbeta during in vivo myocardial ischemia. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11837788&form=6&db=m Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12578131&form=6&db=m Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury. Shock 17(2):127-134, 2002. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485688&form=6&db=m Attenuation of NF-kappaB signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes. causal interaction,unassigned 4,0 2.7.11.10 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18007066&form=6&db=m [IkappaB alpha mRNA expression and its DNA sequence in nasopharyngeal carcinoma cell lines] causal interaction,unassigned 1,0 2.7.11.10 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24075781&form=6&db=m Ikappa B kinase alpha involvement in the development of nasopharyngeal carcinoma through a NF-?B-independent and ERK-dependent pathway. causal interaction,unassigned 3,0 2.7.11.10 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753359&form=6&db=m Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052230&form=6&db=m Adenovirus-mediated IKKbetaKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079494&form=6&db=m A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17200339&form=6&db=m Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17377533&form=6&db=m Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17418780&form=6&db=m IKKalpha at the crossroads of inflammation and metastasis. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909021&form=6&db=m Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288389&form=6&db=m A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19243472&form=6&db=m Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671767&form=6&db=m Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19728335&form=6&db=m High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821485&form=6&db=m Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. ongoing research,unassigned 2,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124483&form=6&db=m miR-146a suppresses invasion of pancreatic cancer cells. causal interaction,unassigned 4,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20220849&form=6&db=m B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21383699&form=6&db=m Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-?B: implication in breast cancer metastasis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27931795&form=6&db=m IKK? inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630674&form=6&db=m The Specific IKK?/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-?B and MAP Kinase Pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3697380&form=6&db=m Characterization of protein tyrosine kinase activity in murine Leydig tumor cells. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631829&form=6&db=m Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8649809&form=6&db=m The ankyrin repeats but not the PEST-like sequences are required for signal-dependent degradation of IkappaBalpha. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8657113&form=6&db=m Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8702657&form=6&db=m Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8940099&form=6&db=m Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214684&form=6&db=m Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9221757&form=6&db=m IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261174&form=6&db=m The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9305938&form=6&db=m Arachidonic acid influences proinflammatory gene induction by stabilizing the inhibitor-kappaBalpha/nuclear factor-kappaB (NF-kappaB) complex, thus suppressing the nuclear translocation of NF-kappaB. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9325328&form=6&db=m Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346485&form=6&db=m IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9374492&form=6&db=m Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388244&form=6&db=m Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9506955&form=6&db=m IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9512545&form=6&db=m Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9516122&form=6&db=m A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9520446&form=6&db=m NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9520464&form=6&db=m Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521814&form=6&db=m Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9605420&form=6&db=m Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9689078&form=6&db=m MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9710600&form=6&db=m Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9727009&form=6&db=m Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9792644&form=6&db=m Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873017&form=6&db=m Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873035&form=6&db=m Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10029068&form=6&db=m Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs. therapeutic application,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066434&form=6&db=m In vivo and in vitro recruitment of an IkappaBalpha-ubiquitin ligase to IkappaBalpha phosphorylated by IKK, leading to ubiquitination. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10066435&form=6&db=m IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10195894&form=6&db=m Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10195895&form=6&db=m Limb and skin abnormalities in mice lacking IKKalpha. ongoing research,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196356&form=6&db=m Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10202930&form=6&db=m Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340377&form=6&db=m Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340762&form=6&db=m Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10346818&form=6&db=m Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391945&form=6&db=m Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409681&form=6&db=m Characterization of NFkappaB activation by detection of green fluorescent protein-tagged IkappaB degradation in living cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10423407&form=6&db=m IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454561&form=6&db=m Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454581&form=6&db=m Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10455128&form=6&db=m Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10477696&form=6&db=m IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10486261&form=6&db=m IkappaBalpha is essential for maintaining basal c-Jun N-terminal kinase (JNK) activation and regulating JNK-mediated resistance to tumor necrosis factor cytotoxicity in L929 cells. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10521444&form=6&db=m Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10523657&form=6&db=m RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10542212&form=6&db=m Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567330&form=6&db=m Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10637284&form=6&db=m Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10644755&form=6&db=m Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648602&form=6&db=m Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10671572&form=6&db=m Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722693&form=6&db=m Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10733566&form=6&db=m Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753891&form=6&db=m Inhibition of IkappaB kinase activity by sodium salicylate in vitro does not reflect its inhibitory mechanism in intact cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10779355&form=6&db=m IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10815922&form=6&db=m Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor". therapeutic application,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10823840&form=6&db=m Tumor necrosis factor-alpha activation of NF-kappa B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10880446&form=6&db=m Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952730&form=6&db=m Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10962577&form=6&db=m Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964953&form=6&db=m Induction of IkappaBalpha mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10973957&form=6&db=m Insulin-like growth factor-I stimulates dephosphorylation of ikappa B through the serine phosphatase calcineurin (protein phosphatase 2B). causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980203&form=6&db=m Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11054378&form=6&db=m Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11055326&form=6&db=m Bcl-2 intersects the NFkappaB signalling pathway and suppresses apoptosis in ventricular myocytes. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059688&form=6&db=m IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062238&form=6&db=m Ras-related GTPase Rhob represses NF-kappaB signaling. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11080499&form=6&db=m Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11152962&form=6&db=m Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11171586&form=6&db=m Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179444&form=6&db=m Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11207569&form=6&db=m A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238593&form=6&db=m Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254493&form=6&db=m Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11264006&form=6&db=m 5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary gland cancer cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266466&form=6&db=m Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278268&form=6&db=m Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278403&form=6&db=m Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFkappaB into an inhibitor of NFkappaB. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11283615&form=6&db=m Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11287960&form=6&db=m IKKalpha controls formation of the epidermis independently of NF-kappaB. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313872&form=6&db=m Differential effects of Ras signaling through NFkappaB on skeletal myogenesis. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313873&form=6&db=m Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356844&form=6&db=m The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11358840&form=6&db=m Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-kappaB activation. causal interaction,therapeutic application,unassigned 2,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359799&form=6&db=m Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11359906&form=6&db=m The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11415944&form=6&db=m Hydrogen peroxide has opposing effects on IKK activity and IkappaBalpha breakdown in airway epithelial cells. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11470788&form=6&db=m IKKgamma /NEMO facilitates the recruitment of the IkappaB proteins into the IkappaB kinase complex. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520600&form=6&db=m Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11543670&form=6&db=m Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606372&form=6&db=m E1A inhibition of radiation-induced NF-kappaB activity through suppression of IKK activity and IkappaB degradation, independent of Akt activation. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694538&form=6&db=m The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11706969&form=6&db=m Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. causal interaction,ongoing research,unassigned 1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723253&form=6&db=m Conjugated polyhydroxybenzene derivatives block tumor necrosis factor-alpha-mediated nuclear factor-kappaB activation and cyclooxygenase-2 gene transcription by targeting IkappaB kinase activity. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11741536&form=6&db=m Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752211&form=6&db=m IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11753981&form=6&db=m High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801607&form=6&db=m Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11884545&form=6&db=m In adenovirus type 12 tumorigenic cells, major histocompatibility complex class I transcription shutoff is overcome by induction of NF-kappaB and relief of COUP-TFII repression. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11907233&form=6&db=m African swine fever virus IAP-like protein induces the activation of nuclear factor kappa B. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11927590&form=6&db=m HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunit. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11948689&form=6&db=m Caspase cleavage product lacking amino-terminus of IkappaBalpha sensitizes resistant cells to TNF-alpha and TRAIL-induced apoptosis. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11954826&form=6&db=m Hyperoxia prolongs tumor necrosis factor-alpha-mediated activation of NF-kappaB: role of IkappaB kinase. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11967992&form=6&db=m Signaling by the Mpl receptor involves IKK and NF-kappaB. diagnostic usage,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11981388&form=6&db=m Clinical implications of inflammatory cytokines in the cochlea: a technical note. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12050393&form=6&db=m Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060665&form=6&db=m Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12078897&form=6&db=m Genetic instability in Hodgkin's lymphoma. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121873&form=6&db=m Different modes of NF-kappaB/Rel activation in pancreatic lobules. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12192055&form=6&db=m The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12207915&form=6&db=m Inhibition of NF-kappaB activation by merlin. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221085&form=6&db=m IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12226754&form=6&db=m The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12228261&form=6&db=m Essential role for verotoxin in sustained stress-activated protein kinase and nuclear factor kappa B signaling, stimulated by Escherichia coli O157:H7 in Vero cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12361720&form=6&db=m Differential activation of the IkappaBalpha and mouse mammary tumor virus promoters by progesterone and glucocorticoid receptors. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12392159&form=6&db=m The possible correlation between activation of NF-kappaB/IkappaB pathway and the susceptibility of tumor cells to paclitaxel-induced apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12402173&form=6&db=m Defective NF-kappaB activation in virus-infected neuronal cells is restored by genetic complementation. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12409308&form=6&db=m Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. causal interaction,ongoing research,unassigned 3,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12459460&form=6&db=m Lymphotoxin-beta receptor mediates NEMO-independent NF-kappaB activation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12482991&form=6&db=m betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12525885&form=6&db=m Mutational analysis of IkappaBalpha in hematologic malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527815&form=6&db=m Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12529410&form=6&db=m Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12565172&form=6&db=m Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12571598&form=6&db=m NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12578813&form=6&db=m I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595341&form=6&db=m Liposomal delivery of heat shock protein 72 into renal tubular cells blocks nuclear factor-kappaB activation, tumor necrosis factor-alpha production, and subsequent ischemia-induced apoptosis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12615800&form=6&db=m Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645577&form=6&db=m c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12682486&form=6&db=m Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro. therapeutic application,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711606&form=6&db=m Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12725325&form=6&db=m Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740336&form=6&db=m Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumour necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748169&form=6&db=m Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771929&form=6&db=m Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12816868&form=6&db=m NF-kappaB activation in premalignant mouse tal-1/scl thymocytes and tumors. ongoing research,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837185&form=6&db=m [Effect and significance of anisodamine on IkappaB kinase-beta in Kupffer cells following hemorrhagic shock] diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12847684&form=6&db=m Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12865782&form=6&db=m Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12867425&form=6&db=m A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883408&form=6&db=m Thiopental inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappaB through suppression of kappaB kinase activity. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890679&form=6&db=m Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939259&form=6&db=m Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14550571&form=6&db=m Ubiquitin activated tumor necrosis factor receptor associated factor-6 (TRAF6) is recycled via deubiquitination. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14585967&form=6&db=m IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14617515&form=6&db=m Short-term modulation of interleukin-1beta signaling by hyperoxia: uncoupling of IkappaB kinase activation and NF-kappaB-dependent gene expression. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14621993&form=6&db=m An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633691&form=6&db=m Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14661019&form=6&db=m Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14673102&form=6&db=m Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715879&form=6&db=m Inhibition of nuclear factor-kappaB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14742634&form=6&db=m Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-kappaB-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976190&form=6&db=m Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14983030&form=6&db=m IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. therapeutic application,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026547&form=6&db=m Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044447&form=6&db=m Human chorionic gonadotropin decreases proliferation and invasion of breast cancer MCF-7 cells by inhibiting NF-kappaB and AP-1 activation. therapeutic application,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084260&form=6&db=m IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094015&form=6&db=m Mathematical model of NF-kappaB regulatory module. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15131062&form=6&db=m Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15140882&form=6&db=m Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15149589&form=6&db=m FoxO: linking new signaling pathways. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15166955&form=6&db=m Inflammatory mechanisms contributing to pancreatic cancer development. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175328&form=6&db=m The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194461&form=6&db=m Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15199157&form=6&db=m IkappaB kinase is an essential component of the Tpl2 signaling pathway. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217903&form=6&db=m Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15226292&form=6&db=m NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252041&form=6&db=m Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252141&form=6&db=m Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256061&form=6&db=m Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294155&form=6&db=m IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313186&form=6&db=m Single injection of naked plasmid encoding alpha-melanocyte-stimulating hormone protects against thioacetamide-induced acute liver failure in mice. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316093&form=6&db=m Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation. causal interaction,therapeutic application,unassigned 4,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319427&form=6&db=m A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15368956&form=6&db=m [Human pathologies associated with NF-kappaB defects] therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15380375&form=6&db=m The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B). therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15469934&form=6&db=m Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15483420&form=6&db=m Theaflavin, a black tea extract, is a novel anti-inflammatory compound. diagnostic usage,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492250&form=6&db=m Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15550384&form=6&db=m Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15617879&form=6&db=m Potential utility of natural polyphenols for reversing fat-induced insulin resistance. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15626457&form=6&db=m Cloning and characterization of a homologue of the alpha inhibitor of NF-kappaB in Rainbow trout (Oncorhynchus mykiss). causal interaction,ongoing research,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15671248&form=6&db=m Inhibition of IkappaBalpha nuclear export as an approach to abrogate nuclear factor-kappaB-dependent cancer cell survival. therapeutic application,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15721144&form=6&db=m The Ectodysplasin and NFkappaB signalling pathways in odontogenesis. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15722197&form=6&db=m NF-kappaB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723090&form=6&db=m Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816521&form=6&db=m Gene transfer of inhibitor kappaB in human lung cancer cell line NCI-H460 inhibits tumorigenesis and angiogenesis in vivo. ongoing research,therapeutic application,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833852&form=6&db=m Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867352&form=6&db=m Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897281&form=6&db=m I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919917&form=6&db=m Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15939736&form=6&db=m IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15942912&form=6&db=m Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951441&form=6&db=m NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16079150&form=6&db=m Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085647&form=6&db=m JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103102&form=6&db=m FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115877&form=6&db=m Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16123045&form=6&db=m Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16155293&form=6&db=m Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16175180&form=6&db=m NF-kappaB: linking inflammation and immunity to cancer development and progression. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178003&form=6&db=m Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178184&form=6&db=m [Expression of nuclear transcription factor kappaB in hamster buccal pouch carcinogenesis] causal interaction,diagnostic usage,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219905&form=6&db=m Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16260783&form=6&db=m TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267042&form=6&db=m Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267367&form=6&db=m Inflammation-activated protein kinases as targets for drug development. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299251&form=6&db=m Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301742&form=6&db=m Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16321974&form=6&db=m Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16382138&form=6&db=m IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16388856&form=6&db=m In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline Involvement of caspase cascades and IkappaBalpha phosphorylation. diagnostic usage,ongoing research,unassigned 2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394182&form=6&db=m Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409294&form=6&db=m Transactivation of CCL20 gene by Epstein-Barr virus latent membrane protein 1. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16436709&form=6&db=m Inhibition of human immunodeficiency virus type 1 replication in latently infected cells by a novel IkappaB kinase inhibitor. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16439676&form=6&db=m Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16464740&form=6&db=m Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappaB inhibitory proteins IkappaBalpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16485028&form=6&db=m NF-kappaB and IKK as therapeutic targets in cancer. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505240&form=6&db=m Reduced Skeletal Muscle Inhibitor of {kappa}B{beta} Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525037&form=6&db=m A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538029&form=6&db=m Current topics in pharmacological research on bone metabolism: osteoclast differentiation regulated by glycosphingolipids. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16539850&form=6&db=m Deguelin inhibits expression of IkappaBalpha protein in Raji and U937 cells. therapeutic application,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540674&form=6&db=m Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16581780&form=6&db=m Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase. ongoing research,therapeutic application,unassigned 2,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16624823&form=6&db=m Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636195&form=6&db=m Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16643855&form=6&db=m A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16651533&form=6&db=m Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677091&form=6&db=m NF-kappaB: a stress-regulated switch for cell survival. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16680015&form=6&db=m Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16687566&form=6&db=m Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16698992&form=6&db=m Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16754954&form=6&db=m Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16774932&form=6&db=m Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16857427&form=6&db=m NF-kappaB activation: nondegradative ubiquitination implicates NEMO. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16891465&form=6&db=m AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951195&form=6&db=m Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor-{kappa}B in Cancer Cells: Delineation of a Novel Pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16998237&form=6&db=m Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016640&form=6&db=m Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17020997&form=6&db=m MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047224&form=6&db=m Regulation and function of IKK and IKK-related kinases. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17072330&form=6&db=m Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079494&form=6&db=m A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17114296&form=6&db=m Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17116751&form=6&db=m IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. therapeutic application,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17132819&form=6&db=m Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17148759&form=6&db=m The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17150968&form=6&db=m Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17172847&form=6&db=m Depletion of histone deacetylase protein: a common consequence of inflammatory cytokine signaling? ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17190815&form=6&db=m Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244487&form=6&db=m NF-kappaB-dependent regulation of matrix metalloproteinase-9 gene expression by lipopolysaccharide in a macrophage cell line RAW 264.7. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244613&form=6&db=m Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17259348&form=6&db=m Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17277159&form=6&db=m Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308110&form=6&db=m Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17322026&form=6&db=m Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17328045&form=6&db=m Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355113&form=6&db=m The transcription factor nuclear factor-kappa B and cancer. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17364953&form=6&db=m 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17377533&form=6&db=m Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409387&form=6&db=m Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409419&form=6&db=m Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17418780&form=6&db=m IKKalpha at the crossroads of inflammation and metastasis. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17428392&form=6&db=m [Lipopolysaccaride influenced peritoneal mesothelial cells on the growth and expression of tumor necrosis factor through nuclear factor kappaB pathway] ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17434128&form=6&db=m Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. causal interaction,ongoing research,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17439942&form=6&db=m Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574021&form=6&db=m Integrative genomic approaches identify IKBKE as a breast cancer oncogene. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17597077&form=6&db=m Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17620428&form=6&db=m Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17644309&form=6&db=m Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671417&form=6&db=m Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17684021&form=6&db=m FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17692539&form=6&db=m Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693255&form=6&db=m IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704647&form=6&db=m The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707270&form=6&db=m Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785555&form=6&db=m Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17854800&form=6&db=m Divergent effect of proteasome inhibition on interleukin-1beta and tumor necrosis factor alpha signaling in human astroglial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897950&form=6&db=m The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909021&form=6&db=m Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940218&form=6&db=m Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17977820&form=6&db=m Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17994120&form=6&db=m Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral blood mononuclear cells, and decreases production of Th1 cytokines via inhibition of nuclear factor kappaB. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18037881&form=6&db=m MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18073529&form=6&db=m All roads lead to mTOR: integrating inflammation and tumor angiogenesis. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18088368&form=6&db=m Differential regulation of c-Jun N-terminal kinase and NF-kappaB pathway by caffeic acid phenethyl ester in astroglial and monocytic cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18203717&form=6&db=m Identification of a Ligand-induced Transient Refractory Period in Nuclear Factor-{kappa}B Signaling. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18223156&form=6&db=m HSP72 protects against obesity-induced insulin resistance. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18224289&form=6&db=m Modification of IkappaBalpha by taurine bromamine inhibits tumor necrosis factor alpha-induced NF-kappaB activation. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230685&form=6&db=m Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18245668&form=6&db=m IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells. causal interaction,therapeutic application,unassigned 1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18282612&form=6&db=m Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301380&form=6&db=m The IkappaB kinase - a bridge between inflammation and cancer. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18317887&form=6&db=m Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362169&form=6&db=m RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18394557&form=6&db=m The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408139&form=6&db=m Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408758&form=6&db=m Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18411264&form=6&db=m Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413730&form=6&db=m Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18450748&form=6&db=m Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468507&form=6&db=m Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18490491&form=6&db=m An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18490760&form=6&db=m Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18506998&form=6&db=m Adenovirus-mediated inhibitor kappaB gene transfer improves the chemosensitivity to anticancer drugs in human lung cancer in vitro and in vivo. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18522681&form=6&db=m Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18548584&form=6&db=m Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559343&form=6&db=m Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18560356&form=6&db=m Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566223&form=6&db=m 17-Acetoxyjolkinolide B irreversibly inhibits IkappaB kinase and induces apoptosis of tumor cells. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566231&form=6&db=m Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18579519&form=6&db=m Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18602896&form=6&db=m The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18604171&form=6&db=m IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632959&form=6&db=m The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor. ongoing research,therapeutic application,unassigned 3,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18635759&form=6&db=m Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18669609&form=6&db=m Purified human plasma glycosaminoglycans reduced NF-kappaB activation, pro-inflammatory cytokine production and apoptosis in LPS-treated chondrocytes. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18674841&form=6&db=m Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18701687&form=6&db=m Nuclear factor kappa B signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18702457&form=6&db=m Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18713798&form=6&db=m Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18755518&form=6&db=m Targeting the PIAS1 SUMO ligase pathway to control inflammation. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772111&form=6&db=m IKKalpha is required to maintain skin homeostasis and prevent skin cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18799149&form=6&db=m The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18949383&form=6&db=m IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952893&form=6&db=m Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957422&form=6&db=m Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957551&form=6&db=m The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18981184&form=6&db=m Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18981220&form=6&db=m TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010928&form=6&db=m IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060479&form=6&db=m Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074436&form=6&db=m Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074890&form=6&db=m IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19085841&form=6&db=m Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19100380&form=6&db=m Ischemic preconditioning improves rat kidney allograft function after ischemia/reperfusion injury: the role of tumor necrosis factor-alpha. diagnostic usage,ongoing research,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19104039&form=6&db=m Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107816&form=6&db=m Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. causal interaction,ongoing research,unassigned 4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116119&form=6&db=m [The alternative NF-kB activation pathway and cancer: friend or foe?] causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147572&form=6&db=m Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19219072&form=6&db=m Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221050&form=6&db=m IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19243472&form=6&db=m Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19249479&form=6&db=m Experimental study on early protective effect of ischemic preconditioning on rat kidney graft. diagnostic usage,ongoing research,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19271152&form=6&db=m Angiotensin II upregulates Toll-like receptor 4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19276252&form=6&db=m Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303104&form=6&db=m Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336568&form=6&db=m Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363130&form=6&db=m Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19436050&form=6&db=m Bortezomib induces canonical NF-{kappa}B activation in multiple myeloma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19444813&form=6&db=m Specific IKKbeta inhibitor IV blocks streptonigrin-induced NF-kappaB activity and potentiates its cytotoxic effect on cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19481526&form=6&db=m Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491262&form=6&db=m N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497997&form=6&db=m Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509265&form=6&db=m IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513071&form=6&db=m Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519169&form=6&db=m Inhibition of NF-kappaB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549902&form=6&db=m Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19557302&form=6&db=m Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19592502&form=6&db=m Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664134&form=6&db=m Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19665994&form=6&db=m Repression of MHC class I transcription by HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB cytoplasmic sequestration. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19666475&form=6&db=m NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19716809&form=6&db=m Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. ongoing research,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723091&form=6&db=m Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19728335&form=6&db=m High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19800637&form=6&db=m Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19818716&form=6&db=m KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851710&form=6&db=m Eugenol inhibits cell proliferation via NF-kappaB suppression in a rat model of gastric carcinogenesis induced by MNNG. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19857958&form=6&db=m Expression of NF-kappaB and IkappaB proteins in skeletal muscle of gastric cancer patients. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19891769&form=6&db=m Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19935080&form=6&db=m Preventive effect of a proteasome inhibitor on the formation of accelerated atherosclerosis in rabbits with uremia. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946332&form=6&db=m Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20001340&form=6&db=m NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038579&form=6&db=m Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043910&form=6&db=m RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20060025&form=6&db=m Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20064526&form=6&db=m The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20129250&form=6&db=m Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20166567&form=6&db=m Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20185581&form=6&db=m Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193848&form=6&db=m Mutations of NFKBIA in biopsy specimens from Hodgkin lymphoma. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20195534&form=6&db=m IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20215516&form=6&db=m Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20220849&form=6&db=m B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227042&form=6&db=m Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20354190&form=6&db=m Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20378831&form=6&db=m Regulation of NF-{kappa}B responses by epigenetic suppression of I{kappa}B{alpha} expression in HCT116 intestinal epithelial cells. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20385620&form=6&db=m RSK2 mediates NF-{kappa}B activity through the phosphorylation of I{kappa}B{alpha} in the TNF-R1 pathway. therapeutic application,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20386985&form=6&db=m Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20403612&form=6&db=m Growth Inhibition and Apoptosis Induction by Tumor Necrosis Factor-alpha in Human Urethral Rhabdosphincter Satellite Cells. ongoing research,therapeutic application,unassigned 4,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20416281&form=6&db=m Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20424119&form=6&db=m Activation of NF-{kappa}B Signaling by Inhibitor of NF-{kappa}B Kinase {beta} Increases Aggressiveness of Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20473944&form=6&db=m Lymphotoxin-beta receptor activation by lymphotoxin-alpha(1)beta(2) and LIGHT promotes tumor growth in an NFkappaB-dependent manner. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530876&form=6&db=m Conditional ablation of Ikkb inhibits melanoma tumor development in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20537930&form=6&db=m IKK-beta inhibitors: an analysis of drug-receptor interaction by using Molecular Docking and Pharmacophore 3D-QSAR approaches. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20600852&form=6&db=m Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20659889&form=6&db=m Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20663042&form=6&db=m Suppression of tumour necrosis factor-alpha by Schizonepeta tenuifolia water extract via inhibition of IkappaBalpha degradation and Jun N-terminal kinase/stress-activated protein kinase activation. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20797350&form=6&db=m Immunohistochemical study of the ubiquitin-nuclear factor-kB pathway in the endometrium of the baboon (Papio anubis) with and without endometriosis. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811662&form=6&db=m Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model. ongoing research,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20829362&form=6&db=m Modification of cysteine-179 of IkappaBalpha kinase by Nimbolide leads to downregulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents. diagnostic usage,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21182083&form=6&db=m Cystatin cures visceral leishmaniasis by NF-?B-mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tpl2-ERK pathway. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21258194&form=6&db=m [The role of NF-kappaB in colon cancer]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21356358&form=6&db=m NF-?B inhibition protects against tumor-induced cardiac atrophy in vivo. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21406399&form=6&db=m CARMA3 is Crucial for EGFR-Induced Activation of NF-{kappa}B and Tumor Progression. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22170213&form=6&db=m Role of K63-linked polyubiquitination in NF-?B signalling: which ligase catalyzes and what molecule is targeted? unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22509384&form=6&db=m Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22715589&form=6&db=m Targeted repression of overexpressed CD30 downregulates NF-kappaB and ERK1/2 pathway in Hodgkin lymphoma cell lines. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22751123&form=6&db=m Requirement of NEMO/IKK? for effective expansion of KRAS-induced precancerous lesions in the pancreas. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23674259&form=6&db=m Characterization of the Inhibitor of KappaB Kinase (IKK) Complex in Granulosa Cell Tumors of the Ovary and Granulosa Cell Tumor-Derived Cell Lines. ongoing research,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717208&form=6&db=m Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23942237&form=6&db=m Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24047462&form=6&db=m B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFkappaB pathways which enhances transcription of MnSOD by accelerating IkappaBalpha degradation in normal and cancer cells. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24075781&form=6&db=m Ikappa B kinase alpha involvement in the development of nasopharyngeal carcinoma through a NF-?B-independent and ERK-dependent pathway. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24618592&form=6&db=m Hepatitis B Virus Polymerase Suppresses NF-?B Signaling by Inhibiting the Activity of IKKs via Interaction with Hsp90?. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753359&form=6&db=m Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25253732&form=6&db=m Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. causal interaction,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25780281&form=6&db=m Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26793999&form=6&db=m The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26867315&form=6&db=m [Effect of Berberine on the Insulin Resistance and TLR4/IKKbeta/NF-kappaB Signaling Pathways in Skeletal Muscle of Obese Rats with Insulin Resistance]. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26980769&form=6&db=m The Prosurvival IKK-Related Kinase IKK? Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27303665&form=6&db=m Gain-of-Function Mutations in the Toll-Like Receptor Pathway: TPL2-Mediated ERK1/ERK2 MAPK Activation, a Path to Tumorigenesis in Lymphoid Neoplasms? causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27859049&form=6&db=m Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27931795&form=6&db=m IKK? inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28008665&form=6&db=m Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-?) via extensive ligand-based modeling and virtual screening. causal interaction,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28716898&form=6&db=m TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207641&form=6&db=m A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase ? in colorectal cancer unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29218456&form=6&db=m Assessment of TANK-binding kinase 1 as a therapeutic target in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29630899&form=6&db=m IKK1/2 protect human cells from TNF-mediated RIPK1-dependent apoptosis in an NF-?B-independent manner. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663549&form=6&db=m Ostreolysin induces browning of adipocytes and ameliorates hepatic steatosis. ongoing research,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29864423&form=6&db=m Inhibition of TBK1 reduces choroidal neovascularization in vitro and in vivo. causal interaction,unassigned 4,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30223576&form=6&db=m Roles for the IKK-Related Kinases TBK1 and IKK? in Cancer. causal interaction,unassigned 2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30949397&form=6&db=m G2019s LRRK2 promotes mitochondrial fission and increases TNF?-mediated neuroinflammation responses. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31862869&form=6&db=m Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/I?B Kinase ? (IKK?)/Nuclear Factor Kappa B (NF-?B) Pathway in Microglia. diagnostic usage,ongoing research,unassigned 2,2,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32082390&form=6&db=m MicroRNA-429 inhibits neuroblastoma cell proliferation, migration and invasion via the NF-?B pathway. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32354736&form=6&db=m Paclitaxel Induces Immunogenic Cell Death in Ovarian Cancer via TLR4/IKK2/SNARE-Dependent Exocytosis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32627230&form=6&db=m Cantharidin-induced acute hepatotoxicity: the role of TNF-?, IKK-?, Bcl-2, Bax and caspase3. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630674&form=6&db=m The Specific IKK?/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-?B and MAP Kinase Pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32746697&form=6&db=m HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32962465&form=6&db=m Targeting TANK-binding kinase 1 (TBK1) in cancer. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33148660&form=6&db=m ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth. ongoing research,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33529438&form=6&db=m Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells. unassigned - 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33679751&form=6&db=m TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34051368&form=6&db=m TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery. therapeutic application,unassigned 1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34111484&form=6&db=m A review on the role of TANK-binding kinase 1 signaling in cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403105&form=6&db=m Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex. diagnostic usage,unassigned 3,0 2.7.11.10 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520306&form=6&db=m Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota. ongoing research,unassigned 1,0 2.7.11.10 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30285578&form=6&db=m T-lymphocyte-specific knockout of IKK-2 or NEMO induces Th17 cells in an experimental nephrotoxic nephritis mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11461937&form=6&db=m Transcriptional and post-transcriptional alterations of IkappaBalpha in active minimal-change nephrotic syndrome. unassigned - 2.7.11.10 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441336&form=6&db=m [Regulatory effect of IkappaBalpha on NF-kappaB activity during viral gene transactivation in patients with steroid responsive simple nephrotic syndrome] ongoing research,unassigned 4,0 2.7.11.10 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973242&form=6&db=m Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.11.10 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17001279&form=6&db=m The role of spinal nuclear factor-kappa B in spinal hyperexcitability. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30528326&form=6&db=m Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 2.7.11.10 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6256479&form=6&db=m Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells. unassigned - 2.7.11.10 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340762&form=6&db=m Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells. ongoing research,unassigned 1,0 2.7.11.10 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10653609&form=6&db=m Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells. causal interaction,ongoing research,unassigned 3,4,0 2.7.11.10 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332116&form=6&db=m Inhibition of the NF-kappaB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells. ongoing research,unassigned 3,0 2.7.11.10 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16088228&form=6&db=m Mu-opioid receptor-mediated phosphorylation of IkappaB kinase in human neuroblastoma SH-SY5Y cells. ongoing research,unassigned 4,0 2.7.11.10 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24117733&form=6&db=m Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.10 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364447&form=6&db=m alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19488402&form=6&db=m IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin. causal interaction,unassigned 4,0 2.7.11.10 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821670&form=6&db=m Specific correction of a splice defect in brain by nutritional supplementation. causal interaction,unassigned 2,0 2.7.11.10 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31223436&form=6&db=m LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson's Disease and Other Neurodegenerative Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26078453&form=6&db=m Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates ?-Synuclein Gene-induced Neurodegeneration. unassigned - 2.7.11.10 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27914807&form=6&db=m Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor ?-mediated neurotoxicity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022868&form=6&db=m LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation. causal interaction,unassigned 4,0 2.7.11.10 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30949397&form=6&db=m G2019s LRRK2 promotes mitochondrial fission and increases TNF?-mediated neuroinflammation responses. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380379&form=6&db=m Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK{epsilon} therapeutic application,unassigned 1,0 2.7.11.10 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406439&form=6&db=m Animal models of steatohepatitis. causal interaction,therapeutic application,unassigned 2,3,0 2.7.11.10 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034032&form=6&db=m IkappaB kinase epsilon: a potential therapeutic target for obesity (and nonalcoholic fatty liver disease)? therapeutic application,unassigned 4,0 2.7.11.10 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33966599&form=6&db=m Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533494&form=6&db=m Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081881&form=6&db=m Diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type dependent manner. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644709&form=6&db=m Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. causal interaction,unassigned 4,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854155&form=6&db=m Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. causal interaction,unassigned 2,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351724&form=6&db=m Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body insulin sensitivity. causal interaction,unassigned 1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19569009&form=6&db=m High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity. ongoing research,unassigned 1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737512&form=6&db=m IKKepsilon: a bridge between obesity and inflammation. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737522&form=6&db=m The protein kinase IKKepsilon regulates energy balance in obese mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754872&form=6&db=m Mechanisms of obesity and related pathology: linking immune responses to metabolic stress. causal interaction,unassigned 1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034032&form=6&db=m IkappaB kinase epsilon: a potential therapeutic target for obesity (and nonalcoholic fatty liver disease)? therapeutic application,unassigned 4,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20371626&form=6&db=m JNK1 and IKK{beta}: molecular links between obesity and metabolic dysfunction. causal interaction,unassigned 4,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21784844&form=6&db=m Defective hypothalamic autophagy directs the central pathogenesis of obesity via IKK-beta/NF-kappaB pathway. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25447767&form=6&db=m Genetic obesity alters recruitment of TANK-binding kinase 1 and AKT into hypothalamic lipid rafts domains. ongoing research,unassigned 1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28585197&form=6&db=m Human Protein Kinases and Obesity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30270002&form=6&db=m Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK? for the treatment of obesity. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30767626&form=6&db=m Molecular mechanism of interactions between Chrysin and I-kappa-B kinase epsilon (IKKe)/Tank Binding Kinase-1(TBK1): Cell based assay and insilico molecular docking studies. therapeutic application,unassigned 3,0 2.7.11.10 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11902829&form=6&db=m Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes. causal interaction,ongoing research,unassigned 2,2,0 2.7.11.10 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879144&form=6&db=m Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes. causal interaction,unassigned 3,0 2.7.11.10 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16571608&form=6&db=m Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17295438&form=6&db=m Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17328045&form=6&db=m Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33562013&form=6&db=m Biochemical and Computational Studies of the Interaction between a Glucosamine Derivative, NAPA, and the IKK? Kinase. unassigned - 2.7.11.10 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252035&form=6&db=m The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. therapeutic application,unassigned 3,0 2.7.11.10 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19830703&form=6&db=m Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis. causal interaction,unassigned 3,0 2.7.11.10 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200955&form=6&db=m IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis. therapeutic application,unassigned 3,0 2.7.11.10 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21913221&form=6&db=m Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16132703&form=6&db=m Okadaic acid induces tyrosine phosphorylation of IkappaBalpha that mediated by PKR pathway in human osteoblastic MG63 cells. ongoing research,unassigned 3,0 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11034066&form=6&db=m Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752211&form=6&db=m IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408758&form=6&db=m Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497997&form=6&db=m Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19517469&form=6&db=m MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664333&form=6&db=m [Effect of topotecan on expression of aquaporin protein 5 and nuclear factor-kappaB in ovarian cancer SKOV3 cells.] ongoing research,unassigned 4,0 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20424119&form=6&db=m Activation of NF-{kappa}B Signaling by Inhibitor of NF-{kappa}B Kinase {beta} Increases Aggressiveness of Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.7.11.10 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32354736&form=6&db=m Paclitaxel Induces Immunogenic Cell Death in Ovarian Cancer via TLR4/IKK2/SNARE-Dependent Exocytosis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633416&form=6&db=m NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system. causal interaction,unassigned 4,0 2.7.11.10 Overnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20808781&form=6&db=m IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824895&form=6&db=m Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14639600&form=6&db=m NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16902410&form=6&db=m IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951195&form=6&db=m Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor-{kappa}B in Cancer Cells: Delineation of a Novel Pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829575&form=6&db=m Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010928&form=6&db=m IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491262&form=6&db=m N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression. ongoing research,unassigned 1,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19845150&form=6&db=m Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20416281&form=6&db=m Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. causal interaction,unassigned 1,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811662&form=6&db=m Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model. ongoing research,unassigned 3,0 2.7.11.10 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22493246&form=6&db=m The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. unassigned - 2.7.11.10 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653813&form=6&db=m Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. causal interaction,diagnostic usage,unassigned 2,1,0 2.7.11.10 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19174608&form=6&db=m Hyperbaric oxygen reduces inflammatory response in acute pancreatitis by inhibiting NF-kappaB activation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.7.11.10 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909021&form=6&db=m Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10467251&form=6&db=m Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845394&form=6&db=m Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's disease. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16437559&form=6&db=m Lrrk2 and Lewy body disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966501&form=6&db=m Clinical heterogeneity of the LRRK2 G2019S mutation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20729864&form=6&db=m Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21676337&form=6&db=m Role of LRRK2 kinase dysfunction in Parkinson disease. causal interaction,unassigned 3,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21768216&form=6&db=m Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22607035&form=6&db=m Pyrazolopyridines as inhibitors of the kinase LRRK2: a patent evaluation (WO2011141756). causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22723946&form=6&db=m The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22985112&form=6&db=m Discovery of Highly Potent, Selective and Brain Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22988865&form=6&db=m Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23078245&form=6&db=m Inhibitors of LRRK2 kinase activity to probe the treatment option in Parkinson's disease. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23721803&form=6&db=m The development of CNS-active LRRK2 inhibitors using property-directed optimisation. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24117733&form=6&db=m Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. causal interaction,ongoing research,unassigned 4,3,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24244710&form=6&db=m Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24900567&form=6&db=m Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26399642&form=6&db=m Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. diagnostic usage,unassigned 3,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26403521&form=6&db=m A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26517051&form=6&db=m LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand? causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27394417&form=6&db=m Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503089&form=6&db=m Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28353288&form=6&db=m Small-Molecule Inhibitors of LRRK2. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28764903&form=6&db=m Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease. therapeutic application,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28973664&form=6&db=m LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease. causal interaction,diagnostic usage,unassigned 4,2,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29127255&form=6&db=m Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130360&form=6&db=m Autophagy and innate immunity: Insights from invertebrate model organisms. unassigned - 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29212815&form=6&db=m Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. unassigned - 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29588215&form=6&db=m Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29622645&form=6&db=m LRRK2 kinase in Parkinson's disease. causal interaction,unassigned 3,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30398148&form=6&db=m A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. unassigned - 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844370&form=6&db=m Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30858560&form=6&db=m Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31223436&form=6&db=m LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson's Disease and Other Neurodegenerative Disorders. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31428781&form=6&db=m RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31527116&form=6&db=m Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31624137&form=6&db=m Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases. causal interaction,unassigned 2,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31804465&form=6&db=m LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32227113&form=6&db=m PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72. causal interaction,unassigned 1,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32268075&form=6&db=m X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease. causal interaction,unassigned 2,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33044192&form=6&db=m LRRK2 and the Endolysosomal System in Parkinson's Disease. causal interaction,unassigned 1,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057100&form=6&db=m Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33509901&form=6&db=m Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33594532&form=6&db=m LRRK2 Ablation Attenuates ?lpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33636387&form=6&db=m The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease. ongoing research,unassigned 2,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33717414&form=6&db=m Analysis of ?-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson's disease. diagnostic usage,unassigned 3,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727250&form=6&db=m LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade. causal interaction,unassigned 4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33765413&form=6&db=m Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes. causal interaction,unassigned 3,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34050929&form=6&db=m The development of inhibitors of leucine-rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34110246&form=6&db=m Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes. unassigned - 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34328508&form=6&db=m From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34419621&form=6&db=m Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16437559&form=6&db=m Lrrk2 and Lewy body disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.11.10 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000063&form=6&db=m Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. ongoing research,unassigned 3,0 2.7.11.10 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10467251&form=6&db=m Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.7.11.10 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607710&form=6&db=m Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfin. diagnostic usage,therapeutic application,unassigned 3,2,0 2.7.11.10 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18580810&form=6&db=m Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells. therapeutic application,unassigned 4,0 2.7.11.10 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=192298&form=6&db=m Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517978&form=6&db=m Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14963119&form=6&db=m IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753951&form=6&db=m A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002568&form=6&db=m Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. causal interaction,ongoing research,unassigned 2,4,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456147&form=6&db=m A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237440&form=6&db=m Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475880&form=6&db=m Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174363&form=6&db=m Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats. therapeutic application,unassigned 1,0 2.7.11.10 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20472709&form=6&db=m Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18636090&form=6&db=m Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130360&form=6&db=m Autophagy and innate immunity: Insights from invertebrate model organisms. unassigned - 2.7.11.10 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32458982&form=6&db=m TBK1, a central kinase in innate immune sensing of nucleic acids and beyond. therapeutic application,unassigned 1,0 2.7.11.10 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12609523&form=6&db=m Pregnancy is associated with suppression of the nuclear factor kappaB/IkappaB activation pathway in peripheral blood mononuclear cells. causal interaction,unassigned 3,0 2.7.11.10 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15469934&form=6&db=m Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20649582&form=6&db=m Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective I-kappaB kinase (IKK) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18474572&form=6&db=m Prion propagation in mice lacking central nervous system NF-kappaB signalling. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10602496&form=6&db=m Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10815922&form=6&db=m Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor". therapeutic application,unassigned 3,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11464285&form=6&db=m Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111695&form=6&db=m Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14689584&form=6&db=m NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon? causal interaction,unassigned 1,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252141&form=6&db=m Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576374&form=6&db=m Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. unassigned - 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856023&form=6&db=m Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. ongoing research,unassigned 3,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052230&form=6&db=m Adenovirus-mediated IKKbetaKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. therapeutic application,unassigned 1,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147887&form=6&db=m [Curcumin-induced the expression of inhibitor kappaBalpha protein in human prostate cancer cells] diagnostic usage,ongoing research,unassigned 3,4,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17259348&form=6&db=m Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17377533&form=6&db=m Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616684&form=6&db=m Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. unassigned - 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468507&form=6&db=m Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19170126&form=6&db=m Over-expression of IkappaB-kinase-epsilon (IKKepsilon/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664134&form=6&db=m Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20207476&form=6&db=m A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 2.7.11.10 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23875250&form=6&db=m Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18075502&form=6&db=m Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis. therapeutic application,unassigned 1,0 2.7.11.10 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811049&form=6&db=m The Nuclear-Factor Kappa B Pathway is Activated in Pterygium. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15573863&form=6&db=m Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16330870&form=6&db=m Activation of nuclear factor-kappaB in airway epithelial cells in patients with chronic obstructive pulmonary disease. diagnostic usage,unassigned 4,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517756&form=6&db=m IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. therapeutic application,unassigned 4,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19478133&form=6&db=m Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19520920&form=6&db=m Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease (COPD). therapeutic application,unassigned 1,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19717478&form=6&db=m Atrophy and hypertrophy signaling in the diaphragm of patients with COPD. causal interaction,diagnostic usage,unassigned 2,4,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193356&form=6&db=m [The function of nuclear factor-erythroid 2-related factor 2 and its association with I-kappa B kinases alpha/beta in a rat model of chronic obstructive pulmonary disease.] causal interaction,unassigned 4,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20688919&form=6&db=m Decreased exercise-induced expression of NF-{kappa}B regulated genes in muscle of COPD patients. causal interaction,unassigned 1,0 2.7.11.10 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21236687&form=6&db=m Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship. causal interaction,therapeutic application,unassigned 3,4,0 2.7.11.10 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475880&form=6&db=m Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. ongoing research,therapeutic application,unassigned 1,4,0 2.7.11.10 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456147&form=6&db=m A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.7.11.10 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583228&form=6&db=m [Perindopril and losartan attenuate bleomycin A5-induced pulmonary fibrosis in rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 2.7.11.10 Reoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16414985&form=6&db=m Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920239&form=6&db=m Gene transfer of IkappaBalpha limits infarct size in a mouse model of myocardial ischemia-reperfusion injury. ongoing research,unassigned 2,0 2.7.11.10 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17675566&form=6&db=m IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19546526&form=6&db=m Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855826&form=6&db=m Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 2.7.11.10 Respiratory Syncytial Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196356&form=6&db=m Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Respiratory Syncytial Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14963119&form=6&db=m IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11225732&form=6&db=m Redox-mediated gene therapies for environmental injury: approaches and concepts. therapeutic application,unassigned 1,0 2.7.11.10 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362475&form=6&db=m Mechanisms by Which S-Albuterol Induces Human Bronchial Smooth Muscle Cell Proliferation. unassigned - 2.7.11.10 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31697998&form=6&db=m Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice. therapeutic application,unassigned 4,0 2.7.11.10 Rocky Mountain Spotted Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15618150&form=6&db=m NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.7.11.10 Rotavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12093168&form=6&db=m Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. unassigned - 2.7.11.10 Salivary Gland Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11264006&form=6&db=m 5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary gland cancer cells. unassigned - 2.7.11.10 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507601&form=6&db=m Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor. ongoing research,unassigned 1,0 2.7.11.10 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384665&form=6&db=m beta-Catenin activity negatively regulates bacteria-induced inflammation. therapeutic application,unassigned 4,0 2.7.11.10 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6283546&form=6&db=m Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase. ongoing research,unassigned 1,0 2.7.11.10 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15624308&form=6&db=m Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=52872&form=6&db=m Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6281757&form=6&db=m Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus. diagnostic usage,therapeutic application,unassigned 1,1,0 2.7.11.10 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18538660&form=6&db=m Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome. unassigned - 2.7.11.10 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17727632&form=6&db=m Nuclear factor-kappaB regulates seizure threshold and gene transcription following convulsant stimulation. causal interaction,unassigned 3,0 2.7.11.10 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10847631&form=6&db=m Inhibition of LPS-induced NFkappaB activation by a glucan ligand involves down-regulation of IKKbeta kinase activity and altered phosphorylation and degradation of IkappaBalpha. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069829&form=6&db=m NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance. causal interaction,diagnostic usage,unassigned 3,4,0 2.7.11.10 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17899301&form=6&db=m Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 2.7.11.10 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19371254&form=6&db=m Paeoniflorin Inhibits Systemic Inflammation and Improves Survival in Experimental Sepsis. causal interaction,therapeutic application,unassigned 1,2,0 2.7.11.10 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31173970&form=6&db=m Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis. causal interaction,therapeutic application,unassigned 2,4,0 2.7.11.10 Severe Fever with Thrombocytopenia Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021900&form=6&db=m Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10477696&form=6&db=m IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.11.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485688&form=6&db=m Attenuation of NF-kappaB signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes. causal interaction,unassigned 4,0 2.7.11.10 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696914&form=6&db=m Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Sjogren's Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696914&form=6&db=m Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Skin Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10195895&form=6&db=m Limb and skin abnormalities in mice lacking IKKalpha. ongoing research,unassigned 4,0 2.7.11.10 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079494&form=6&db=m A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200541&form=6&db=m IKKbeta Leads to an Inflammatory Skin Disease Resembling Interface Dermatitis. therapeutic application,unassigned 2,0 2.7.11.10 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079494&form=6&db=m A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772111&form=6&db=m IKKalpha is required to maintain skin homeostasis and prevent skin cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.11.10 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18818691&form=6&db=m IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. causal interaction,unassigned 3,0 2.7.11.10 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10505977&form=6&db=m Inhibition of peripheral NF-kappaB activation by central action of alpha-melanocyte-stimulating hormone. ongoing research,therapeutic application,unassigned 4,1,0 2.7.11.10 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363678&form=6&db=m IkBalpha promoter polymorphisms in patients with ankylosing spondylitis. causal interaction,ongoing research,unassigned 1,1,0 2.7.11.10 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33717069&form=6&db=m Down-Regulation of LOC645166 in T Cells of Ankylosing Spondylitis Patients Promotes the NF-?B Signaling via Decreasingly Blocking Recruitment of the IKK Complex to K63-Linked Polyubiquitin Chains. unassigned - 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252836&form=6&db=m Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. ongoing research,therapeutic application,unassigned 2,1,0 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492250&form=6&db=m Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818647&form=6&db=m Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16953224&form=6&db=m Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. causal interaction,unassigned 1,0 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707270&form=6&db=m Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. diagnostic usage,ongoing research,unassigned 4,4,0 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785205&form=6&db=m LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. diagnostic usage,unassigned 3,0 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18448428&form=6&db=m SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB. causal interaction,therapeutic application,unassigned 3,3,0 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20695076&form=6&db=m CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex. causal interaction,unassigned 3,0 2.7.11.10 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821700&form=6&db=m Curcumin Treatment Suppresses IKK{beta} Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3 2.7.11.10 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33653948&form=6&db=m Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.7.11.10 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17727632&form=6&db=m Nuclear factor-kappaB regulates seizure threshold and gene transcription following convulsant stimulation. causal interaction,unassigned 3,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10889159&form=6&db=m H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells. diagnostic usage,unassigned 3,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12417257&form=6&db=m 5-Fluorouracil inhibits nitric oxide production through the inactivation of IkappaB kinase in stomach cancer cells. therapeutic application,unassigned 2,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15275881&form=6&db=m Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer. therapeutic application,unassigned 4,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15814628&form=6&db=m Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495515&form=6&db=m Helicobacter pylori Induces I{kappa}B Kinase {alpha} Nuclear Translocation and Chemokine Production in Gastric Epithelial Cells. causal interaction,unassigned 2,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18466396&form=6&db=m Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19778522&form=6&db=m Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.11.10 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132559&form=6&db=m IkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese. ongoing research,unassigned 1,0 2.7.11.10 Superinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15564469&form=6&db=m Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway. ongoing research,unassigned 2,0 2.7.11.10 Synucleinopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30150626&form=6&db=m LRRK2 kinase regulates ?-synuclein propagation via RAB35 phosphorylation. therapeutic application,unassigned 3,0 2.7.11.10 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021900&form=6&db=m Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715879&form=6&db=m Inhibition of nuclear factor-kappaB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.7.11.10 Trichuriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17322906&form=6&db=m Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11508443&form=6&db=m Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.7.11.10 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29789389&form=6&db=m LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022529&form=6&db=m Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28819387&form=6&db=m TBK1 Promote Bladder Cancer Cell Proliferation and Migration via Akt Signaling. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18560356&form=6&db=m Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells. therapeutic application,unassigned 1,0 2.7.11.10 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10373514&form=6&db=m Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. unassigned - 2.7.11.10 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15016878&form=6&db=m The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradation. ongoing research,therapeutic application,unassigned 1,1,0 2.7.11.10 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17005676&form=6&db=m Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells. ongoing research,unassigned 2,0 2.7.11.10 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266467&form=6&db=m Inhibition of IkappaB Kinase by Vaccinia Virus Virulence Factor B14. unassigned - 2.7.11.10 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596385&form=6&db=m Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication. ongoing research,therapeutic application,unassigned 3,1,0 2.7.11.10 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20444990&form=6&db=m Mutations in modified virus Ankara protein 183 render it a non-functional counterpart of B14, an inhibitor of nuclear factor kappa B activation. causal interaction,unassigned 1,0 2.7.11.10 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21474453&form=6&db=m Mapping the i{kappa}B kinase beta (ikk{beta})-binding interface of B14, a vaccinia virus inhibitor of IKK{beta}-mediated activation of nuclear factor kappa B. therapeutic application,unassigned 1,0 2.7.11.10 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14560235&form=6&db=m Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.7.11.10 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363130&form=6&db=m Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10355388&form=6&db=m The NFkappaB inhibitory peptide, IkappaBalpha, prevents human vascular smooth muscle proliferation. diagnostic usage,therapeutic application,unassigned 3,4,0 2.7.11.10 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25982245&form=6&db=m Peptide-based inhibition of I?B kinase/nuclear factor-?B pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes. causal interaction,therapeutic application,unassigned 4,2,0 2.7.11.10 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071880&form=6&db=m I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.7.11.10 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15367631&form=6&db=m Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28049150&form=6&db=m FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions. ongoing research,unassigned 1,0 2.7.11.10 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28954889&form=6&db=m HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress. causal interaction,unassigned 1,0 2.7.11.10 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130360&form=6&db=m Autophagy and innate immunity: Insights from invertebrate model organisms. unassigned - 2.7.11.10 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27654289&form=6&db=m The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1. therapeutic application,unassigned 1,0 2.7.11.10 Viremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31200068&form=6&db=m Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression. causal interaction,unassigned 3,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10074115&form=6&db=m IkappaB-mediated inhibition of virus-induced beta interferon transcription. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196356&form=6&db=m Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626894&form=6&db=m JNK2 and IKKbeta are required for activating the innate response to viral infection. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702806&form=6&db=m Triggering the interferon antiviral response through an IKK-related pathway. causal interaction,unassigned 3,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794154&form=6&db=m Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14963119&form=6&db=m IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. causal interaction,therapeutic application,unassigned 3,2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210742&form=6&db=m The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. causal interaction,therapeutic application,unassigned 4,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15367631&form=6&db=m Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15764595&form=6&db=m Role of cyclophilin B in activation of interferon regulatory factor-3. causal interaction,unassigned 1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380379&form=6&db=m Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK{epsilon} therapeutic application,unassigned 1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16751392&form=6&db=m Differential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection. unassigned - 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16908599&form=6&db=m Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. therapeutic application,unassigned 2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17138672&form=6&db=m Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17236232&form=6&db=m Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332413&form=6&db=m Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. causal interaction,unassigned 3,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17351338&form=6&db=m Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection. causal interaction,ongoing research,unassigned 4,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355113&form=6&db=m The transcription factor nuclear factor-kappa B and cancer. therapeutic application,unassigned 1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17376932&form=6&db=m Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein. ongoing research,unassigned 2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17599067&form=6&db=m Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. unassigned - 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652396&form=6&db=m Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. unassigned - 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18308615&form=6&db=m IkappaB kinase beta (IKKbeta/IKK2/IKBKB)-A key molecule in signaling to the transcription factor NF-kappaB. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467330&form=6&db=m Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. causal interaction,ongoing research,unassigned 2,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18636090&form=6&db=m Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307177&form=6&db=m USE OF THE PHARMACOLOGICAL INHIBITOR BX795 TO STUDY THE REGULATION AND PHYSIOLOGICAL ROLES OF TBK1 AND IKK{varepsilon}: A DISTINCT UPSTREAM KINASE MEDIATES SER172 PHOSPHORYLATION AND ACTIVATION. unassigned - 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19380491&form=6&db=m Ubiquitin-regulated recruitment of IKK{epsilon} to MAVS interferon signaling adapter. causal interaction,therapeutic application,unassigned 1,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19851467&form=6&db=m Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein m013. therapeutic application,unassigned 4,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20817314&form=6&db=m Molecular cloning of IKKbeta from the mandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNV infection. causal interaction,ongoing research,unassigned 1,2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25082354&form=6&db=m The role of the IKK complex in viral infections. causal interaction,ongoing research,unassigned 3,2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27016603&form=6&db=m MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. therapeutic application,unassigned 3,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28087918&form=6&db=m [Research progress on the role of TANK-binding kinase 1 in anti-virus innate immune response]. causal interaction,therapeutic application,unassigned 3,1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28904192&form=6&db=m The Role of Herpes Simplex Virus Type 1 ?34.5 in the Regulation of IRF3 Signaling. causal interaction,unassigned 2,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29755463&form=6&db=m The Role of Optineurin in Antiviral Type I Interferon Production. ongoing research,unassigned 1,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30932713&form=6&db=m TANK-binding kinase 1 as a novel therapeutic target for viral diseases. causal interaction,therapeutic application,unassigned 4,4,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31074891&form=6&db=m Predicting and validating a model of suppressor of IKKepsilon through biophysical characterization. causal interaction,unassigned 3,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31200068&form=6&db=m Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression. causal interaction,unassigned 3,0 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31835635&form=6&db=m KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly. unassigned - 2.7.11.10 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34011520&form=6&db=m Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6. ongoing research,unassigned 3,0 2.7.11.10 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11003574&form=6&db=m Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression. unassigned - 2.7.11.10 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566386&form=6&db=m Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis differently modulate human dendritic cell functions resulting in divergent prevalence of Th17-polarized responses. causal interaction,unassigned 3,0 2.7.11.10 Yellow Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32574095&form=6&db=m Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine. therapeutic application,unassigned 1,0