2.7.1.67 1-phosphatidylinositol 4-kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30564627&form=6&db=m PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome. causal interaction,unassigned 4,0 2.7.1.67 22q11 Deletion Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893707&form=6&db=m An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. causal interaction,unassigned 4,0 2.7.1.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846158&form=6&db=m Membrane-associated phosphatidylinositol kinase of R3230AC mammary tumors and normal mammary glands and effects of insulin on tumor enzyme activity. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.1.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315381&form=6&db=m Phosphatidylinositol kinase is reduced in Alzheimer's disease. causal interaction,unassigned 4,0 2.7.1.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7986826&form=6&db=m Effects of Alzheimer's disease-related beta amyloid protein fragments on enzymes metabolizing phosphoinositides in brain. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8156090&form=6&db=m Evidence for a selective decrease in type 1 phosphatidylinositol kinase activity in brains of patients with Alzheimer's disease. causal interaction,unassigned 4,0 2.7.1.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395284&form=6&db=m Reduced phosphatidylinositol kinase activity in Alzheimer's disease: effects of age and onset. causal interaction,unassigned 2,0 2.7.1.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8397585&form=6&db=m Platelet phosphatidylinositol kinase activity is not altered in Alzheimer disease. causal interaction,unassigned 3,0 2.7.1.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188002&form=6&db=m Reductions in brain phosphatidylinositol kinase activities in Alzheimer's disease. causal interaction,unassigned 4,0 2.7.1.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569259&form=6&db=m Pathophysiological concentrations of amyloid beta proteins directly inhibit rat brain and recombinant human type II phosphatidylinositol 4-kinase activity. unassigned - 2.7.1.67 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550165&form=6&db=m Red cell membrane phosphatidylinositol kinase activity in hemolytic anemias and myeloproliferative diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.7.1.67 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29386109&form=6&db=m A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. causal interaction,unassigned 1,0 2.7.1.67 Anemia, Hemolytic, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550165&form=6&db=m Red cell membrane phosphatidylinositol kinase activity in hemolytic anemias and myeloproliferative diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.7.1.67 Arthrogryposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25855803&form=6&db=m Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis. causal interaction,unassigned 3,0 2.7.1.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7887960&form=6&db=m Quercetin down-regulates signal transduction in human breast carcinoma cells. causal interaction,ongoing research,unassigned 1,3,0 2.7.1.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7968216&form=6&db=m Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.1.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25368680&form=6&db=m Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer. causal interaction,unassigned 3,0 2.7.1.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31554935&form=6&db=m Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.7.1.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32230859&form=6&db=m Using Phosphatidylinositol Phosphorylation as Markers for Hyperglycemic Related Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.7.1.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6326140&form=6&db=m Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis. unassigned - 2.7.1.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7521578&form=6&db=m Murine pancreatic ductal adenocarcinoma produced by in vitro transduction of polyoma middle T oncogene into the islets of Langerhans. diagnostic usage,unassigned 3,0 2.7.1.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388919&form=6&db=m Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organisation and lateral diffusion of PI4KIIalpha at the trans-Golgi Network. causal interaction,therapeutic application,unassigned 4,3,0 2.7.1.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34504076&form=6&db=m Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. diagnostic usage,ongoing research,unassigned 2,1,0 2.7.1.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723587&form=6&db=m Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin. causal interaction,ongoing research,unassigned 1,4,0 2.7.1.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7789876&form=6&db=m Evidence for tight coupling of gonadotropin-releasing hormone receptors to phosphatidylinositol kinase in plasma membrane from ovarian carcinomas. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.1.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7968216&form=6&db=m Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.1.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9343925&form=6&db=m Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 2.7.1.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11172601&form=6&db=m Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.1.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000369&form=6&db=m Enhanced phosphatidylinositol kinase activity is associated with early stages of hepatocarcinogenesis and hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.1.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8168087&form=6&db=m 1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.1.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8869739&form=6&db=m Current issues in the regulation of signal transduction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.1.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9343925&form=6&db=m Intracellular signalling: phosphatidylinositol lipid metabolism in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 2.7.1.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19775453&form=6&db=m The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.7.1.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27991882&form=6&db=m Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture. causal interaction,unassigned 2,0 2.7.1.67 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2433285&form=6&db=m Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells. ongoing research,therapeutic application,unassigned 2,4,0 2.7.1.67 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719028&form=6&db=m Dependence of cyclopiazonic-acid-induced muscle contractures on extracellular Ca2+. therapeutic application,unassigned 1,0 2.7.1.67 Cutis Laxa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32418222&form=6&db=m Novel defect in phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) at the membrane-enzyme interface is associated with metabolic cutis laxa. causal interaction,unassigned 3,0 2.7.1.67 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358777&form=6&db=m Phosphatidylinositol 4-kinase ? mutations cause nonsyndromic sensorineural deafness and inner ear malformation. causal interaction,unassigned 3,0 2.7.1.67 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18646052&form=6&db=m Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome. causal interaction,unassigned 1,0 2.7.1.67 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20052689&form=6&db=m Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome. causal interaction,unassigned 1,0 2.7.1.67 DiGeorge Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29925309&form=6&db=m Accurate diagnosis of spinal muscular atrophy and 22q11.2 deletion syndrome using limited deoxynucleotide triphosphates and high-resolution melting. diagnostic usage,unassigned 1,0 2.7.1.67 Dystonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32520805&form=6&db=m Recent genetic advances in early-onset dystonia. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.67 Dystonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32657892&form=6&db=m Recent genetic advances in early-onset dystonia. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.67 Enterovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22124328&form=6&db=m ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites. unassigned - 2.7.1.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30564627&form=6&db=m PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome. causal interaction,unassigned 4,0 2.7.1.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502460&form=6&db=m Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.1.67 Hemangioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7689725&form=6&db=m Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src. causal interaction,therapeutic application,unassigned 3,1,0 2.7.1.67 Hepatitis A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23572552&form=6&db=m ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. ongoing research,therapeutic application,unassigned 2,1,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19376974&form=6&db=m Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. diagnostic usage,unassigned 3,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697487&form=6&db=m Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication. causal interaction,therapeutic application,unassigned 1,1,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022594&form=6&db=m The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement. causal interaction,unassigned 1,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22825118&form=6&db=m Anti-Hepatitis C Virus Activity and Toxicity of Type III Phosphatidylinositol-4-Kinase Beta Inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22896614&form=6&db=m Evaluation of phosphatidylinositol-4-kinase III? as a hepatitis C virus drug target. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675303&form=6&db=m The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A. causal interaction,unassigned 4,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23944386&form=6&db=m Discovery of Selective Small Molecule Type III Phosphatidylinositol 4-Kinase Alpha (PI4KIII?) Inhibitors as Anti Hepatitis C (HCV) Agents. causal interaction,therapeutic application,unassigned 3,3,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792752&form=6&db=m Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner. therapeutic application,unassigned 2,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28004945&form=6&db=m Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase III? (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. causal interaction,therapeutic application,unassigned 1,4,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28566381&form=6&db=m Hepatitis C Virus Subverts Human Choline Kinase-? To Bridge Phosphatidylinositol-4-Kinase III? (PI4KIII?) and NS5A and Upregulates PI4KIII? Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication. ongoing research,therapeutic application,unassigned 1,1,0 2.7.1.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29509402&form=6&db=m Activity-Based Phosphatidylinositol Kinase Probes Detect Changes to Protein-Protein Interactions During Hepatitis C Virus Replication. unassigned - 2.7.1.67 Hermanski-Pudlak Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010779&form=6&db=m Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.1.67 Hermanski-Pudlak Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23676666&form=6&db=m The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type II?. ongoing research,therapeutic application,unassigned 1,1,0 2.7.1.67 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34415310&form=6&db=m Biallelic PI4KA variants cause neurological, intestinal and immunological disease. unassigned - 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19605471&form=6&db=m Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19608626&form=6&db=m Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19901060&form=6&db=m Tetraspanin CD81 is required for Listeria monocytogenes invasion. therapeutic application,unassigned 1,0 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697487&form=6&db=m Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication. causal interaction,therapeutic application,unassigned 1,1,0 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949814&form=6&db=m West Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids. causal interaction,therapeutic application,unassigned 1,1,0 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22253445&form=6&db=m Phosphatidylinositol 4-Kinase III? Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28701404&form=6&db=m Enterovirus 3A facilitates viral replication by promoting PI4KB-ACBD3 interaction. unassigned - 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29024767&form=6&db=m Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase III? or oxysterol binding protein. ongoing research,therapeutic application,unassigned 3,1,0 2.7.1.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34196914&form=6&db=m ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles. unassigned - 2.7.1.67 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704666&form=6&db=m Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized Madin-Darby canine kidney cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.1.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29983910&form=6&db=m Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity. therapeutic application,unassigned 1,0 2.7.1.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30564627&form=6&db=m PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome. causal interaction,unassigned 4,0 2.7.1.67 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32187552&form=6&db=m APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin. therapeutic application,unassigned 1,0 2.7.1.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17122963&form=6&db=m The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cells. ongoing research,unassigned 4,0 2.7.1.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18316730&form=6&db=m Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity. unassigned - 2.7.1.67 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32507070&form=6&db=m Puncta intended: connecting the dots between autophagy and cell stress networks. ongoing research,unassigned 1,0 2.7.1.67 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29889526&form=6&db=m Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria. ongoing research,therapeutic application,unassigned 1,4,0 2.7.1.67 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21652733&form=6&db=m A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110{gamma} Isoform in Medulloblastoma Cell Proliferation and Chemoresistance. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.7.1.67 Myeloproliferative Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550165&form=6&db=m Red cell membrane phosphatidylinositol kinase activity in hemolytic anemias and myeloproliferative diseases. ongoing research,therapeutic application,unassigned 3,1,0 2.7.1.67 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11940366&form=6&db=m Association of the phosphatidylinositol signal pathway with prolonged myocardial ischemia. ongoing research,therapeutic application,unassigned 1,1,0 2.7.1.67 Myoclonus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30564627&form=6&db=m PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome. causal interaction,unassigned 4,0 2.7.1.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866581&form=6&db=m Identification of genes related to invasion and metastasis in pancreatic cancer by cDNA representational difference analysis. causal interaction,therapeutic application,unassigned 4,2,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1648699&form=6&db=m Polyoma virus middle tumor antigen stimulates membrane-associated protein kinase C at lower levels than required for phosphatidylinositol kinase activation and neoplastic transformation. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1693771&form=6&db=m Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity. unassigned - 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846158&form=6&db=m Membrane-associated phosphatidylinositol kinase of R3230AC mammary tumors and normal mammary glands and effects of insulin on tumor enzyme activity. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988548&form=6&db=m Enzymatic synthesis and hydrolysis of [32P]phosphatidylinositol phosphate. unassigned - 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000369&form=6&db=m Enhanced phosphatidylinositol kinase activity is associated with early stages of hepatocarcinogenesis and hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7968216&form=6&db=m Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8168087&form=6&db=m 1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8869739&form=6&db=m Current issues in the regulation of signal transduction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470366&form=6&db=m Amplification of signal transduction capacity and down-regulation by drugs. unassigned - 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10697500&form=6&db=m Amplified increase in signal transduction activity in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12959183&form=6&db=m Oncogenic pathways implicated in ovarian epithelial cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054198&form=6&db=m Down-regulation of increased signal transduction capacity in human cancer cells. unassigned - 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20154717&form=6&db=m PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24366037&form=6&db=m Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase ?- but not ?-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation. therapeutic application,unassigned 2,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25368680&form=6&db=m Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer. causal interaction,unassigned 3,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25502460&form=6&db=m Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme. causal interaction,diagnostic usage,unassigned 4,1,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28766170&form=6&db=m Aegle marmelos differentially affects hepatic markers of glycolysis, insulin signalling pathway, hypoxia, and inflammation in HepG2 cells grown in fructose versus glucose-rich environment. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29280156&form=6&db=m The Many Roles of Type II Phosphatidylinositol 4-Kinases in Membrane Trafficking: New Tricks for Old Dogs. causal interaction,unassigned 2,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29386109&form=6&db=m A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. causal interaction,unassigned 1,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30606737&form=6&db=m Silencing of type II phosphatidylinositol 4-kinase ? stabilizes prostate apoptosis response-4 and induces apoptosis in cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30659093&form=6&db=m A complex between phosphatidylinositol 4 kinase II? and integrin ?3?1 is required for N-glycan sialylation in cancer cells. unassigned - 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31554935&form=6&db=m Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0 2.7.1.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31759986&form=6&db=m Analysis of the microarray gene expression for breast cancer progression after the application modified logistic regression. therapeutic application,unassigned 1,0 2.7.1.67 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30564627&form=6&db=m PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome. causal interaction,unassigned 4,0 2.7.1.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340817&form=6&db=m Phosphatidylinositol Kinase Activity in Ovarian Cancer Cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.1.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32507070&form=6&db=m Puncta intended: connecting the dots between autophagy and cell stress networks. ongoing research,unassigned 1,0 2.7.1.67 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31747597&form=6&db=m PI4KB on Inclusion Bodies Formed by ER Membrane Remodeling Facilitates Replication of Human Parainfluenza Virus Type 3. ongoing research,therapeutic application,unassigned 3,1,0 2.7.1.67 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618608&form=6&db=m Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. unassigned - 2.7.1.67 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34415322&form=6&db=m Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy. unassigned - 2.7.1.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7986826&form=6&db=m Effects of Alzheimer's disease-related beta amyloid protein fragments on enzymes metabolizing phosphoinositides in brain. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.67 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009430&form=6&db=m Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease. causal interaction,unassigned 3,0 2.7.1.67 Polymicrogyria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25855803&form=6&db=m Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis. causal interaction,unassigned 3,0 2.7.1.67 Psychomotor Agitation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30564627&form=6&db=m PI4K2A deficiency in an intellectual disability, epilepsy, myoclonus, akathisia syndrome. causal interaction,unassigned 4,0 2.7.1.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2426580&form=6&db=m Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells. unassigned - 2.7.1.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8168087&form=6&db=m 1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.7.1.67 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2426580&form=6&db=m Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells. unassigned - 2.7.1.67 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822141&form=6&db=m Elevated phosphatidylinositol kinase activity in Rous sarcoma virus-transformed cells. Lack of evidence for enzyme translocation. diagnostic usage,ongoing research,unassigned 3,3,0 2.7.1.67 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018507&form=6&db=m Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells. ongoing research,therapeutic application,unassigned 2,1,0 2.7.1.67 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6326140&form=6&db=m Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis. unassigned - 2.7.1.67 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618608&form=6&db=m Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. unassigned - 2.7.1.67 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8157627&form=6&db=m Regulation of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae by CDP-diacylglycerol. causal interaction,unassigned 1,0 2.7.1.67 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32726584&form=6&db=m Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p. therapeutic application,unassigned 3,0 2.7.1.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32507070&form=6&db=m Puncta intended: connecting the dots between autophagy and cell stress networks. ongoing research,unassigned 1,0 2.7.1.67 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704666&form=6&db=m Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized Madin-Darby canine kidney cells. ongoing research,therapeutic application,unassigned 1,1,0 2.7.1.67 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767056&form=6&db=m Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.1.67 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100512&form=6&db=m Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. ongoing research,unassigned 2,0