2.5.1.6 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19653152&form=6&db=m [Do ethical guidelines provide assistance in clinical practice?] causal interaction,unassigned 1,0 2.5.1.6 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23588207&form=6&db=m Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.5.1.6 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27671891&form=6&db=m Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders. causal interaction,therapeutic application,unassigned 4,1,0 2.5.1.6 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7549452&form=6&db=m Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.5.1.6 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8872870&form=6&db=m Influence of vitamin B12 on brain methionine adenosyltransferase activity in senile dementia of the Alzheimer's type. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.5.1.6 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28450540&form=6&db=m APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. causal interaction,unassigned 3,0 2.5.1.6 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10415148&form=6&db=m Methionine adenosyltransferase activity in erythrocytes and spinal cord of patients with sporadic amyotrophic lateral sclerosis. ongoing research,unassigned 1,0 2.5.1.6 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557781&form=6&db=m MAT2A mutations predispose individuals to thoracic aortic aneurysms. causal interaction,unassigned 2,0 2.5.1.6 Aortic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557781&form=6&db=m MAT2A mutations predispose individuals to thoracic aortic aneurysms. causal interaction,unassigned 2,0 2.5.1.6 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25258128&form=6&db=m Do family physicians choose self-assessment activities based on what they know or don't know? therapeutic application,unassigned 1,0 2.5.1.6 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9300936&form=6&db=m Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.5.1.6 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25694464&form=6&db=m Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. causal interaction,diagnostic usage,unassigned 2,2,0 2.5.1.6 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27098076&form=6&db=m [Severe hypercholesterolaemia--when to use the proprotein convertase subtilisin-kexin type 9 protease inhibitors (PCSK9 inhibitors)? Polish Society of Cardiology experts' group statement]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 2.5.1.6 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1999315&form=6&db=m The role of methanethiol in the pathogenesis of hepatic encephalopathy. causal interaction,unassigned 3,0 2.5.1.6 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492278&form=6&db=m Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress. causal interaction,ongoing research,unassigned 1,1,0 2.5.1.6 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26418898&form=6&db=m Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.5.1.6 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27816361&form=6&db=m Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.5.1.6 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32064155&form=6&db=m Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer. causal interaction,diagnostic usage,unassigned 3,3,0 2.5.1.6 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34065390&form=6&db=m MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients. causal interaction,diagnostic usage,unassigned 4,4,0 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498786&form=6&db=m Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis. causal interaction,unassigned 2,0 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20363925&form=6&db=m Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247894&form=6&db=m THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22213190&form=6&db=m Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23241961&form=6&db=m MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23468134&form=6&db=m Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636201&form=6&db=m Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26429724&form=6&db=m GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes. unassigned - 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141455&form=6&db=m Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32080887&form=6&db=m Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.5.1.6 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34349244&form=6&db=m Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.5.1.6 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18698677&form=6&db=m Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19025580&form=6&db=m Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 2.5.1.6 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636201&form=6&db=m Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31552788&form=6&db=m Diminished S-adenosylmethionine biosynthesis and its metabolism in a model of hepatocellular carcinoma is recuperated by an adenosine derivative. unassigned - 2.5.1.6 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6337873&form=6&db=m Translation in vitro and regulation of mouse liver S-adenosylmethionine synthetase messenger RNA. diagnostic usage,ongoing research,unassigned 2,2,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=499498&form=6&db=m Differential effects of dimethylsulfoxide on S-adenosylmethionine synthetase from rat liver and hepatoma. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2062260&form=6&db=m Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXIV. Repeated embryonic genes in liver. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2345265&form=6&db=m Separation of different forms of S-adenosylmethionine synthetase by fast protein liquid chromatography. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4302534&form=6&db=m S-adenosylmethionine synthetase activity in some normal rat tissues and transplantable hepatomas. ongoing research,unassigned 3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6847699&form=6&db=m Chemotherapeutic potential of methionine analogue inhibitors of tumor-derived methionine adenosyltransferases. ongoing research,unassigned 3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7396950&form=6&db=m S-Adenosylmethionine synthetase isozyme patterns from rat hepatoma induced by N-2-fluorenylacetamide. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8224230&form=6&db=m Expression of non-hepatic-type S-adenosylmethionine synthetase isozyme in rat hepatomas induced by 3'-methyl-4-dimethylaminoazobenzene. causal interaction,ongoing research,unassigned 2,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393662&form=6&db=m Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. diagnostic usage,ongoing research,unassigned 2,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8903381&form=6&db=m Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9048633&form=6&db=m Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression. ongoing research,unassigned 3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9278450&form=6&db=m Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9537246&form=6&db=m Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10627284&form=6&db=m Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. ongoing research,therapeutic application,unassigned 2,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11131452&form=6&db=m Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 2,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208539&form=6&db=m Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. causal interaction,ongoing research,unassigned 3,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11427482&form=6&db=m The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12029623&form=6&db=m Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation. causal interaction,ongoing research,unassigned 3,3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12671891&form=6&db=m Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530285&form=6&db=m Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15033934&form=6&db=m Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. ongoing research,therapeutic application,unassigned 3,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15590672&form=6&db=m Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15852300&form=6&db=m Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry. causal interaction,ongoing research,unassigned 4,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054984&form=6&db=m Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. ongoing research,unassigned 3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614071&form=6&db=m S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. diagnostic usage,ongoing research,unassigned 1,2,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17154373&form=6&db=m Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. causal interaction,diagnostic usage,unassigned 3,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441811&form=6&db=m Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045590&form=6&db=m Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167064&form=6&db=m Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336669&form=6&db=m S-Adenosylmethionine in cell growth, apoptosis and liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19115422&form=6&db=m CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20146079&form=6&db=m Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20363925&form=6&db=m Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20815019&form=6&db=m Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. causal interaction,ongoing research,unassigned 4,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20890892&form=6&db=m Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. causal interaction,ongoing research,unassigned 1,2,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247894&form=6&db=m THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21460102&form=6&db=m Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678410&form=6&db=m Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22270009&form=6&db=m Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III Characterization of DDX3X as a target of S-adenosylmethionine. diagnostic usage,ongoing research,unassigned 1,3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23072598&form=6&db=m Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23073625&form=6&db=m S-adenosylmethionine in liver health, injury, and cancer. causal interaction,ongoing research,unassigned 1,2,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23189196&form=6&db=m NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23218308&form=6&db=m Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses. ongoing research,unassigned 3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23241961&form=6&db=m MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23468134&form=6&db=m Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23665184&form=6&db=m Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098708&form=6&db=m MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24377546&form=6&db=m 5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production. therapeutic application,unassigned 1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25075345&form=6&db=m Structure and function study of the complex that synthesizes S-adenosylmethionine. causal interaction,ongoing research,unassigned 1,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27548429&form=6&db=m The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases. causal interaction,unassigned 3,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141455&form=6&db=m Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29448301&form=6&db=m Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29749642&form=6&db=m A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29844127&form=6&db=m SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30050996&form=6&db=m Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073374&form=6&db=m MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes. diagnostic usage,unassigned 1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273451&form=6&db=m Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication. unassigned - 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34349244&form=6&db=m Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34449924&form=6&db=m S-Adenosylmethionine Inhibits La Ribonucleoprotein Domain Family Member 1 in Murine Liver and Human Liver Cancer Cells. ongoing research,unassigned 4,0 2.5.1.6 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100031091&form=6&db=m Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses ongoing research,unassigned 3,0 2.5.1.6 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636201&form=6&db=m Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Cardiac Tamponade http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33520789&form=6&db=m Homemade cardiac and vein cannulation ultrasound phantoms for trauma management training in resource-limited settings. diagnostic usage,therapeutic application,unassigned 2,2,0 2.5.1.6 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3327494&form=6&db=m Stress-induced activation of the sympathetic nervous system. unassigned - 2.5.1.6 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335551&form=6&db=m MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.5.1.6 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27878791&form=6&db=m New concepts in the management of dyslipidaemiaa. causal interaction,therapeutic application,unassigned 3,4,0 2.5.1.6 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28434484&form=6&db=m Practical aspects in the management of statin-associated muscle symptoms (SAMS). causal interaction,therapeutic application,unassigned 3,4,0 2.5.1.6 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969892&form=6&db=m Deregulated methionine adenosyltransferase ?1, c-myc and maf proteins interplay promotes cholangiocarcinoma growth in mice and humans. ongoing research,unassigned 4,0 2.5.1.6 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141455&form=6&db=m Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.5.1.6 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34349244&form=6&db=m Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.5.1.6 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969892&form=6&db=m Deregulated methionine adenosyltransferase ?1, c-myc and maf proteins interplay promotes cholangiocarcinoma growth in mice and humans. ongoing research,unassigned 4,0 2.5.1.6 Cholestasis, Intrahepatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039163&form=6&db=m [Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.5.1.6 Citrullinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039163&form=6&db=m [Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.5.1.6 Clubfoot http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788391&form=6&db=m Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.5.1.6 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31745632&form=6&db=m Semi-automated vs. manual 3D reconstruction of central mesenteric vascular models: the surgeon's verdict. diagnostic usage,therapeutic application,unassigned 3,1,0 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17631143&form=6&db=m Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21406062&form=6&db=m Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23325601&form=6&db=m Methionine adenosyltransferase 2B-GIT1 interplay activates MEK1-ERK1/2 to induce growth in human liver and colon cancer. ongoing research,unassigned 3,0 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23363077&form=6&db=m Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23588207&form=6&db=m Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636201&form=6&db=m Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25794709&form=6&db=m Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells. ongoing research,unassigned 3,0 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416353&form=6&db=m Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.5.1.6 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33374288&form=6&db=m S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells. ongoing research,therapeutic application,unassigned 3,4,0 2.5.1.6 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10955733&form=6&db=m Correlation between the expression of methionine adenosyltransferase and the stages of human colorectal carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0 2.5.1.6 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23363077&form=6&db=m Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27213918&form=6&db=m Cullin 3 targets methionine adenosyltransferase II? for ubiquitylation-mediated degradation and regulates colorectal cancer cell proliferation. therapeutic application,unassigned 2,0 2.5.1.6 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788756&form=6&db=m Constitutive overexpression of cystathionine gamma-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine. unassigned - 2.5.1.6 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9300936&form=6&db=m Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.5.1.6 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34157486&form=6&db=m 50-gene risk profiles in peripheral blood predict COVID-19 outcomes: A retrospective, multicenter cohort study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.5.1.6 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395369&form=6&db=m Physicians' Acceptance of Triage Guidelines in the Context of the COVID-19 Pandemic: A Qualitative Study. ongoing research,unassigned 1,0 2.5.1.6 cystathionine beta-synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739680&form=6&db=m Glycine N -methyltransferase deficiency: a new patient with a novel mutation. causal interaction,diagnostic usage,unassigned 4,3,0 2.5.1.6 cystathionine beta-synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23993429&form=6&db=m Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening. causal interaction,unassigned 4,0 2.5.1.6 cystathionine beta-synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29943221&form=6&db=m Newborn screening for homocystinurias: recent recommendations versus current practice. causal interaction,unassigned 3,0 2.5.1.6 cystathionine beta-synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740731&form=6&db=m Newborn screening for homocystinurias: Recent recommendations versus current practice. causal interaction,unassigned 3,0 2.5.1.6 cystathionine gamma-synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2725296&form=6&db=m Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia. causal interaction,unassigned 4,0 2.5.1.6 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9116037&form=6&db=m Nucleotide sequence and developmental expression of Acanthamoeba S-adenosylmethionine synthetase gene. unassigned - 2.5.1.6 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17636994&form=6&db=m 4-Mercaptophenylboronic acid SAMs on gold: comparison with SAMs derived from thiophenol, 4-mercaptophenol, and 4-mercaptobenzoic acid. causal interaction,unassigned 1,0 2.5.1.6 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19787434&form=6&db=m A gene expression analysis of syncytia laser microdissected from the roots of the Glycine max (soybean) genotype PI 548402 (Peking) undergoing a resistant reaction after infection by Heterodera glycines (soybean cyst nematode). unassigned - 2.5.1.6 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7549452&form=6&db=m Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.5.1.6 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8770875&form=6&db=m Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. causal interaction,unassigned 4,0 2.5.1.6 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9482646&form=6&db=m Normal brain myelination in a patient homozygous for a mutation that encodes a severely truncated methionine adenosyltransferase I/III. diagnostic usage,unassigned 1,0 2.5.1.6 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10674710&form=6&db=m Molecular genetics of hepatic methionine adenosyltransferase deficiency. causal interaction,unassigned 4,0 2.5.1.6 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10677294&form=6&db=m Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations. causal interaction,unassigned 4,0 2.5.1.6 Dental Caries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30001533&form=6&db=m Multilevel Analysis of Dental Caries in Swedish Children and Adolescents in Relation to Socioeconomic Status. diagnostic usage,unassigned 2,0 2.5.1.6 Dermatomyositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31401791&form=6&db=m Exercise training attenuates insulin resistance and improves ?-cell function in patients with systemic autoimmune myopathies: a pilot study. therapeutic application,unassigned 1,0 2.5.1.6 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809655&form=6&db=m Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year. diagnostic usage,therapeutic application,unassigned 1,1,0 2.5.1.6 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33259671&form=6&db=m Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study. therapeutic application,unassigned 2,0 2.5.1.6 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809655&form=6&db=m Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year. diagnostic usage,therapeutic application,unassigned 1,1,0 2.5.1.6 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18405345&form=6&db=m Protocol for SAMS (Support and Advice for Medication Study): a randomised controlled trial of an intervention to support patients with type 2 diabetes with adherence to medication. therapeutic application,unassigned 1,0 2.5.1.6 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33259671&form=6&db=m Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study. therapeutic application,unassigned 2,0 2.5.1.6 Disorders of Excessive Somnolence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32886102&form=6&db=m Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea: The SAMS Randomized Clinical Trial. causal interaction,therapeutic application,unassigned 1,2,0 2.5.1.6 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29878063&form=6&db=m Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence. causal interaction,unassigned 4,0 2.5.1.6 Dwarfism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968345&form=6&db=m A hypersensitive response-like reaction is involved in hybrid weakness in F1 plants of the cross Capsicum annuum × Capsicum chinense. unassigned - 2.5.1.6 Endocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1893018&form=6&db=m [Efficacy evaluation of cloxacillin and cloxacillin-gentamicin in an experimental model of methicillin-sensitive Staphylococcus aureus] ongoing research,unassigned 2,0 2.5.1.6 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22276910&form=6&db=m Identification of endometriosis-related genes by representational difference analysis of cDNA. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.5.1.6 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33841663&form=6&db=m PPAR? induces the paroxysm of endometriosis by regulating the transcription of MAT2A gene. unassigned - 2.5.1.6 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809655&form=6&db=m Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year. diagnostic usage,therapeutic application,unassigned 1,1,0 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12163143&form=6&db=m Role of abnormal methionine metabolism in alcoholic liver injury. unassigned - 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15852300&form=6&db=m Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry. causal interaction,ongoing research,unassigned 4,1,0 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614071&form=6&db=m S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. diagnostic usage,ongoing research,unassigned 1,2,0 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336669&form=6&db=m S-Adenosylmethionine in cell growth, apoptosis and liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21837751&form=6&db=m Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice. causal interaction,ongoing research,unassigned 3,3,0 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23073625&form=6&db=m S-adenosylmethionine in liver health, injury, and cancer. causal interaction,ongoing research,unassigned 1,2,0 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28132890&form=6&db=m Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis. diagnostic usage,ongoing research,unassigned 2,4,0 2.5.1.6 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34449924&form=6&db=m S-Adenosylmethionine Inhibits La Ribonucleoprotein Domain Family Member 1 in Murine Liver and Human Liver Cancer Cells. ongoing research,unassigned 4,0 2.5.1.6 Foot Deformities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788391&form=6&db=m Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.5.1.6 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465491&form=6&db=m Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo. unassigned - 2.5.1.6 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9267563&form=6&db=m Histologic and morphometric grading of gliomas. A comparative survival analysis. therapeutic application,unassigned 2,0 2.5.1.6 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33336744&form=6&db=m Hsa_circ_0000337 promotes proliferation, migration and invasion in glioma by competitively binding miRNA-942-5p and thus upregulates MAT2A. causal interaction,unassigned 2,0 2.5.1.6 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33859984&form=6&db=m SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.5.1.6 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30549046&form=6&db=m Clinical features related to statin-associated muscle symptoms. causal interaction,diagnostic usage,unassigned 2,1,0 2.5.1.6 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2362543&form=6&db=m Decreased activities of S-adenosylmethionine synthetase isozymes in hereditary hepatitis in Long-Evans rats. causal interaction,ongoing research,unassigned 2,3,0 2.5.1.6 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067322&form=6&db=m Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31234428&form=6&db=m Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.5.1.6 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247894&form=6&db=m THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.5.1.6 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23072598&form=6&db=m Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.5.1.6 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25271158&form=6&db=m Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells. ongoing research,unassigned 1,0 2.5.1.6 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497121&form=6&db=m dBMHCC: A comprehensive hepatocellular carcinoma (HCC) biomarker database provides a reliable prediction system for novel HCC phosphorylated biomarkers. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.5.1.6 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9278450&form=6&db=m Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity. ongoing research,unassigned 4,0 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2725296&form=6&db=m Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia. causal interaction,unassigned 4,0 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6785521&form=6&db=m Homocystinuria: studies on cystathionine beta-synthase, S-adenosylmethionine synthetase and cystathionase activities in skin fibroblasts. diagnostic usage,ongoing research,unassigned 1,3,0 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278456&form=6&db=m Biochemical basis for the dominant inheritance of hypermethioninemia associated with the R264H mutation of the MAT1A gene. A monomeric methionine adenosyltransferase with tripolyphosphatase activity. causal interaction,unassigned 3,0 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569761&form=6&db=m Reversible white matter lesion in methionine adenosyltransferase I/III deficiency. causal interaction,therapeutic application,unassigned 3,2,0 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17473966&form=6&db=m Effect of hypermethioninemia on some parameters of oxidative stress and on Na(+),K (+)-ATPase activity in hippocampus of rats. ongoing research,therapeutic application,unassigned 3,1,0 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18500573&form=6&db=m Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: Diagnosis in an expanded neonatal screening programme. unassigned - 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23993429&form=6&db=m Clinical and metabolic findings in patients with methionine adenosyltransferase I/III deficiency detected by newborn screening. causal interaction,unassigned 4,0 2.5.1.6 Homocystinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31641591&form=6&db=m Hypermethioninemia in Campania: Results from 10?years of newborn screening. causal interaction,unassigned 1,0 2.5.1.6 Hydrocephalus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16174526&form=6&db=m Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth. therapeutic application,unassigned 4,0 2.5.1.6 Hyperargininemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039163&form=6&db=m [Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.5.1.6 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29307522&form=6&db=m Acute exercise alters homocysteine plasma concentration in an intensity-dependent manner due increased methyl flux in liver of rats. causal interaction,unassigned 2,0 2.5.1.6 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33237943&form=6&db=m Modeling statin myopathy in a human skeletal muscle microphysiological system. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.5.1.6 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15288538&form=6&db=m Immunomodulatory effects of mineral fibres in occupationally exposed workers. causal interaction,diagnostic usage,unassigned 4,3,0 2.5.1.6 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809655&form=6&db=m Maintenance of Certification for Family Physicians (MC-FP) Self Assessment Modules (SAMs): The First Year. diagnostic usage,therapeutic application,unassigned 1,1,0 2.5.1.6 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335551&form=6&db=m MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.5.1.6 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25258128&form=6&db=m Do family physicians choose self-assessment activities based on what they know or don't know? therapeutic application,unassigned 1,0 2.5.1.6 Illusions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20126451&form=6&db=m Real-time decreased sensitivity to an audio-visual illusion during goal-directed reaching. therapeutic application,unassigned 1,0 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11858172&form=6&db=m Overexpression of the tomato Asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica plants. unassigned - 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14709722&form=6&db=m Gene switching in Amoeba proteus caused by endosymbiotic bacteria. causal interaction,unassigned 1,0 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17406792&form=6&db=m Transcriptional regulation of genes involved in the pathways of biosynthesis and supply of methyl units in response to powdery mildew attack and abiotic stresses in wheat. diagnostic usage,ongoing research,unassigned 2,2,0 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247894&form=6&db=m THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26001410&form=6&db=m Culture and adenoviral infection of sinoatrial node myocytes from adult mice. unassigned - 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26658051&form=6&db=m Gene Expression Analysis of Plum pox virus (Sharka) Susceptibility/Resistance in Apricot (Prunus armeniaca L.). causal interaction,therapeutic application,unassigned 4,2,0 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27805586&form=6&db=m Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice. causal interaction,diagnostic usage,unassigned 1,1,0 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363853&form=6&db=m Disruption of the methionine cycle and reduced cellular gluthathione levels underlie potex-potyvirus synergism in Nicotiana benthamiana. ongoing research,unassigned 2,0 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30157283&form=6&db=m Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. causal interaction,therapeutic application,unassigned 2,1,0 2.5.1.6 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30480846&form=6&db=m Resistance against Ralstonia solanacearum in tomato depends on the methionine cycle and the ?-aminobutyric acid metabolic pathway. ongoing research,unassigned 1,0 2.5.1.6 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383241&form=6&db=m Evaluation of various cleaning methods to remove bacillus spores from spacecraft hardware materials. unassigned - 2.5.1.6 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27173395&form=6&db=m Detection of influenza virus by a biosensor based on the method combining electrochemiluminescence on binary SAMs modified Au electrode with an immunoliposome encapsulating Ru (II) complex. ongoing research,unassigned 2,0 2.5.1.6 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465491&form=6&db=m Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo. unassigned - 2.5.1.6 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8373829&form=6&db=m Differential kinetic properties of L-2-amino-4-methylthio-cis-but-3-enoic acid, a methionine analog inhibitor of S-adenosylmethionine synthetase. ongoing research,unassigned 4,0 2.5.1.6 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213491&form=6&db=m S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.5.1.6 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29126055&form=6&db=m Estrogen-responsive gene networks in the teleost liver: What are the key molecular indicators? diagnostic usage,ongoing research,unassigned 3,3,0 2.5.1.6 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32456310&form=6&db=m MAT2A as Key Regulator and Therapeutic Target in MLLr Leukemogenesis. diagnostic usage,ongoing research,unassigned 3,4,0 2.5.1.6 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16310247&form=6&db=m Effect of biomaterial surface properties on fibronectin-alpha5beta1 integrin interaction and cellular attachment. diagnostic usage,ongoing research,unassigned 1,2,0 2.5.1.6 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3980460&form=6&db=m S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterization. diagnostic usage,ongoing research,unassigned 1,3,0 2.5.1.6 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31362681&form=6&db=m Quercetin Promotes Cell Cycle Arrest and Apoptosis and Attenuates the Proliferation of Human Chronic Myeloid Leukemia Cell Line-K562 Through Interaction with HSPs (70 and 90), MAT2A and FOXM1. ongoing research,unassigned 1,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2307400&form=6&db=m Inactivation and dissociation of S-adenosylmethionine synthetase by modification of sulfhydryl groups and its possible occurrence in cirrhosis. therapeutic application,unassigned 2,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3192166&form=6&db=m Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis. causal interaction,ongoing research,unassigned 1,2,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11131452&form=6&db=m Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 2,1,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301045&form=6&db=m Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine. therapeutic application,unassigned 1,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482628&form=6&db=m Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats. diagnostic usage,ongoing research,unassigned 3,2,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404313&form=6&db=m Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. causal interaction,ongoing research,unassigned 1,3,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20815019&form=6&db=m Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. causal interaction,ongoing research,unassigned 4,4,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32108965&form=6&db=m Leptin promotes methionine adenosyltransferase 2A expression in hepatic stellate cells by the downregulation of E2F-4 via the ?-catenin pathway. therapeutic application,unassigned 1,0 2.5.1.6 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34148046&form=6&db=m Curcumin Affects Leptin-Induced Expression of Methionine Adenosyltransferase 2A in Hepatic Stellate Cells by Inhibition of JNK Signaling. unassigned - 2.5.1.6 Liver Cirrhosis, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8280752&form=6&db=m Abnormal metabolism of S-adenosyl-L-methionine in hypoxic rat liver. Similarities to its abnormal metabolism in alcoholic cirrhosis. causal interaction,diagnostic usage,unassigned 1,1,0 2.5.1.6 Liver Cirrhosis, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393662&form=6&db=m Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. diagnostic usage,ongoing research,unassigned 2,4,0 2.5.1.6 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453503&form=6&db=m Methionine adenosyltransferase and liver disease: it's all about SAM. unassigned - 2.5.1.6 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067322&form=6&db=m Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167064&form=6&db=m Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. ongoing research,unassigned 4,0 2.5.1.6 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25075345&form=6&db=m Structure and function study of the complex that synthesizes S-adenosylmethionine. causal interaction,ongoing research,unassigned 1,1,0 2.5.1.6 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31496615&form=6&db=m Methionine adenosyltransferases in liver cancer. unassigned - 2.5.1.6 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301045&form=6&db=m Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine. therapeutic application,unassigned 1,0 2.5.1.6 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054984&form=6&db=m Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. ongoing research,unassigned 3,0 2.5.1.6 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16958675&form=6&db=m Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease. diagnostic usage,unassigned 2,0 2.5.1.6 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067322&form=6&db=m Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8903381&form=6&db=m Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9537246&form=6&db=m Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10216131&form=6&db=m Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. ongoing research,unassigned 3,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10627284&form=6&db=m Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. ongoing research,therapeutic application,unassigned 2,1,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10677369&form=6&db=m Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 1A gene. ongoing research,unassigned 4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208539&form=6&db=m Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. causal interaction,ongoing research,unassigned 3,4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054984&form=6&db=m Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. ongoing research,unassigned 3,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441811&form=6&db=m Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18041713&form=6&db=m Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta. ongoing research,unassigned 3,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167064&form=6&db=m Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. ongoing research,unassigned 4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043323&form=6&db=m Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. unassigned - 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20363925&form=6&db=m Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20564331&form=6&db=m Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. causal interaction,unassigned 2,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247894&form=6&db=m THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21460102&form=6&db=m Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23363077&form=6&db=m Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23588207&form=6&db=m Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23814050&form=6&db=m Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. ongoing research,unassigned 3,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25338671&form=6&db=m S-Adenosylmethionine and methylthioadenosine inhibit ?-catenin signaling by multiple mechanisms in liver and colon cancer. diagnostic usage,unassigned 2,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416353&form=6&db=m Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141455&form=6&db=m Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073374&form=6&db=m MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes. diagnostic usage,unassigned 1,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32080887&form=6&db=m Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.5.1.6 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34349244&form=6&db=m Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.5.1.6 Liver Neoplasms, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3950912&form=6&db=m Isozyme-specific enzyme inhibitors. 10. Adenosine 5'-triphosphate derivatives as substrates or inhibitors of methionine adenosyltransferases of rat normal and hepatoma tissues. unassigned - 2.5.1.6 Liver Neoplasms, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8903381&form=6&db=m Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.5.1.6 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7896885&form=6&db=m Impaired alveolar macrophage function in smoke inhalation injury. unassigned - 2.5.1.6 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258296&form=6&db=m Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development. ongoing research,unassigned 1,0 2.5.1.6 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22542325&form=6&db=m Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.5.1.6 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3790625&form=6&db=m Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes. unassigned - 2.5.1.6 Maple Syrup Urine Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039163&form=6&db=m [Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=564605&form=6&db=m Hypermethioninemia in an infant. causal interaction,unassigned 3,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=889406&form=6&db=m [Still another cause of hypermethioninemia in children: S-adenosylmethionine synthetase deficiency] causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1683972&form=6&db=m Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. causal interaction,therapeutic application,unassigned 2,1,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2725296&form=6&db=m Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia. causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2920533&form=6&db=m Transamination of methionine in humans. unassigned - 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3339126&form=6&db=m Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency. causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3812486&form=6&db=m Hepatic methionine adenosyltransferase deficiency in a 31-year-old man. causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4421454&form=6&db=m Methionine adenosyltransferase deficiency: new enzymatic defect associated with hypermethioninemia. causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7229751&form=6&db=m Hypermethioninemia associated with methionine adenosyltransferase deficiency: clinical, morphologic, and biochemical observations on four patients. causal interaction,diagnostic usage,unassigned 4,1,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7560086&form=6&db=m Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency. causal interaction,unassigned 3,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10674710&form=6&db=m Molecular genetics of hepatic methionine adenosyltransferase deficiency. causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15935930&form=6&db=m Spectrum of hypermethioninemia in neonatal screening. causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16077118&form=6&db=m Rickettsial metK-encoded methionine adenosyltransferase expression in an Escherichia coli metK deletion strain. therapeutic application,unassigned 1,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17473966&form=6&db=m Effect of hypermethioninemia on some parameters of oxidative stress and on Na(+),K (+)-ATPase activity in hippocampus of rats. ongoing research,therapeutic application,unassigned 3,1,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18210212&form=6&db=m Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report. causal interaction,unassigned 4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19585268&form=6&db=m Inherited disorders in the conversion of methionine to homocysteine. causal interaction,therapeutic application,unassigned 4,1,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22178350&form=6&db=m S-adenosylmethionine treatment in methionine adenosyltransferase deficiency, a case report. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23430947&form=6&db=m Methionine Adenosyltransferase I/III Deficiency in Portugal: High Frequency of a Dominantly Inherited Form in a Small Area of Douro High Lands. causal interaction,unassigned 3,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039163&form=6&db=m [Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.5.1.6 methionine adenosyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31061746&form=6&db=m Mild Persistent Isolated Hypermethioninemia Identified through Newborn Screening in Michigan. causal interaction,unassigned 4,0 2.5.1.6 methylenetetrahydrofolate dehydrogenase (nad+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18210212&form=6&db=m Reversible leukoencephalopathy with acute neurological deterioration and permanent residua in classical homocystinuria: A case report. causal interaction,unassigned 4,0 2.5.1.6 methylenetetrahydrofolate dehydrogenase (nad+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29943221&form=6&db=m Newborn screening for homocystinurias: recent recommendations versus current practice. causal interaction,unassigned 3,0 2.5.1.6 methylenetetrahydrofolate dehydrogenase (nad+) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740731&form=6&db=m Newborn screening for homocystinurias: Recent recommendations versus current practice. causal interaction,unassigned 3,0 2.5.1.6 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19698171&form=6&db=m Protocol for the saMS trial (supportive adjustment for multiple sclerosis): a randomized controlled trial comparing cognitive behavioral therapy to supportive listening for adjustment to multiple sclerosis. therapeutic application,unassigned 4,0 2.5.1.6 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730954&form=6&db=m A Randomized Controlled Trial of Cognitive Behavioral Therapy (CBT) for Adjusting to Multiple Sclerosis (the saMS Trial): Does CBT Work and for Whom Does It Work? therapeutic application,unassigned 3,0 2.5.1.6 Muscle Cramp http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31756491&form=6&db=m A practical algorithm for the management of patients with statin-associated muscle symptoms. unassigned - 2.5.1.6 Muscle Weakness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30657065&form=6&db=m Physical exercise among patients with systemic autoimmune myopathies. causal interaction,ongoing research,unassigned 1,1,0 2.5.1.6 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277775&form=6&db=m Rationale for the use of metformin and exercise to counteract statin-associated side effects. causal interaction,unassigned 3,0 2.5.1.6 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25694464&form=6&db=m Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. causal interaction,diagnostic usage,unassigned 2,2,0 2.5.1.6 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27897416&form=6&db=m Curcumin: An effective adjunct in patients with statin-associated muscle symptoms? causal interaction,unassigned 1,0 2.5.1.6 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28963307&form=6&db=m Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults: a protocol for a systematic review and meta-analysis of randomised controlled trials. therapeutic application,unassigned 1,0 2.5.1.6 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33270123&form=6&db=m Effect of Pharmacogenetic Testing for Statin Myopathy Risk vs Usual Care on Blood Cholesterol: A Randomized Clinical Trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 2.5.1.6 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33339465&form=6&db=m The insidious impact of under-diagnosed proximal weakness induced by statins. unassigned - 2.5.1.6 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25694464&form=6&db=m Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. causal interaction,diagnostic usage,unassigned 2,2,0 2.5.1.6 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27199064&form=6&db=m Statin-Associated Side Effects. causal interaction,unassigned 1,0 2.5.1.6 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27993387&form=6&db=m Low vitamin D does not predict statin associated muscle symptoms but is associated with transient increases in muscle damage and pain. therapeutic application,unassigned 1,0 2.5.1.6 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29027135&form=6&db=m Does Coenzyme Q10 Supplementation Mitigate Statin-Associated Muscle Symptoms? Pharmacological and Methodological Considerations. causal interaction,therapeutic application,unassigned 3,4,0 2.5.1.6 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30251222&form=6&db=m Statin-Associated Muscle Disease: Advances in Diagnosis and Management. causal interaction,therapeutic application,unassigned 3,4,0 2.5.1.6 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30268577&form=6&db=m Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies. ongoing research,therapeutic application,unassigned 1,3,0 2.5.1.6 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30935447&form=6&db=m Vitamin D Supplementation to Treat Statin-Associated Muscle Symptoms: A Review. causal interaction,diagnostic usage,unassigned 4,1,0 2.5.1.6 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9300936&form=6&db=m Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 2.5.1.6 Myotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30268577&form=6&db=m Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies. ongoing research,therapeutic application,unassigned 1,3,0 2.5.1.6 Myxoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19615026&form=6&db=m Giant superficial angiomyxoma of the vulva: a case report and review of the literature. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.5.1.6 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22542325&form=6&db=m Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.5.1.6 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23241961&form=6&db=m MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.5.1.6 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23468134&form=6&db=m Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA-based treatment in liver cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.5.1.6 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29749642&form=6&db=m A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=188546&form=6&db=m Partial purification and characterization of tumor and liver S-adenosylmethionine synthetases. unassigned - 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6337873&form=6&db=m Translation in vitro and regulation of mouse liver S-adenosylmethionine synthetase messenger RNA. diagnostic usage,ongoing research,unassigned 2,2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6855473&form=6&db=m Studies on the activities of some methyltransferases in the livers and tumor cells from tumor-bearing mice. causal interaction,ongoing research,unassigned 1,3,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6929012&form=6&db=m Demonstration of an altered S-adenosylmethionine synthetase in human malignant tumors xenografted into athymic nude mice. causal interaction,ongoing research,unassigned 3,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7155132&form=6&db=m Differences in the active-site region of tumor versus normal isozymes of mammalian ATP:L-methionine S-adenosyltransferase. ongoing research,unassigned 1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8064840&form=6&db=m Bone resorbing activity of surface-associated material from Actinobacillus actinomycetemcomitans and Eikenella corrodens. therapeutic application,unassigned 1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8866660&form=6&db=m Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208539&form=6&db=m Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. causal interaction,ongoing research,unassigned 3,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11427482&form=6&db=m The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11999115&form=6&db=m Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae. unassigned - 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060674&form=6&db=m Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12671891&form=6&db=m Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12915128&form=6&db=m Expression and subcellular localization of Ewing sarcoma (EWS) protein is affected by the methylation process. unassigned - 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530285&form=6&db=m Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067322&form=6&db=m Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16236172&form=6&db=m Generation, annotation, analysis and database integration of 16,500 white spruce EST clusters. diagnostic usage,unassigned 2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256130&form=6&db=m Mixed self-assembled monolayers (SAMs) consisting of methoxy-tri(ethylene glycol)-terminated and alkyl-terminated dimethylchlorosilanes control the non-specific adsorption of proteins at oxidic surfaces. diagnostic usage,unassigned 2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17317269&form=6&db=m Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells. causal interaction,unassigned 4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441811&form=6&db=m Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045590&form=6&db=m Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells. causal interaction,ongoing research,unassigned 1,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18095270&form=6&db=m Prostate-specific genes and their regulation by dihydrotestosterone. causal interaction,ongoing research,unassigned 1,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336669&form=6&db=m S-Adenosylmethionine in cell growth, apoptosis and liver cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19425048&form=6&db=m Dendritic cell responses to self-assembled monolayers of defined chemistries. unassigned - 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19615026&form=6&db=m Giant superficial angiomyxoma of the vulva: a case report and review of the literature. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20363925&form=6&db=m Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20564331&form=6&db=m Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. causal interaction,unassigned 2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20815019&form=6&db=m Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. causal interaction,ongoing research,unassigned 4,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247894&form=6&db=m THE X PROTEIN OF HEPATITIS B VIRUS INHIBITS APOPTOSIS IN HEPATOMA CELLS THROUGH ENHANCING THE METHIONINE ADENOSYLTRANSFERASE 2A GENE EXPRESSION AND REDUCING S-ADENOSYL-METHIONINE PRODUCTION. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21460102&form=6&db=m Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22542325&form=6&db=m Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23072598&form=6&db=m Hypermethylation-repressed methionine adenosyltransferase 1A as a potential biomarker for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23363077&form=6&db=m Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098708&form=6&db=m MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636201&form=6&db=m Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900080&form=6&db=m PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation. unassigned - 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25925782&form=6&db=m Acetylation of MAT II? represses tumour cell growth and is decreased in human hepatocellular cancer. causal interaction,unassigned 1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416353&form=6&db=m Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553945&form=6&db=m Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. causal interaction,unassigned 3,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28683199&form=6&db=m Unfolding IGDQ Peptides for Engineering Motogenic Interfaces. ongoing research,unassigned 2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28839175&form=6&db=m Oxygen nanobubbles revert hypoxia by methylation programming. therapeutic application,unassigned 2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28880543&form=6&db=m The Transition-State Structure for Human MAT2A from Isotope Effects. causal interaction,diagnostic usage,unassigned 3,3,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141455&form=6&db=m Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29448301&form=6&db=m Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29733835&form=6&db=m Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. causal interaction,ongoing research,unassigned 1,2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29749642&form=6&db=m A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30712196&form=6&db=m S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells. ongoing research,therapeutic application,unassigned 3,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31058319&form=6&db=m PARTICLE - The RNA podium for genomic silencers. diagnostic usage,therapeutic application,unassigned 3,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31061538&form=6&db=m Methionine is a metabolic dependency of tumor-initiating cells. causal interaction,unassigned 1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31234428&form=6&db=m Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31320408&form=6&db=m Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae. unassigned - 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31600961&form=6&db=m Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32080887&form=6&db=m Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32456310&form=6&db=m MAT2A as Key Regulator and Therapeutic Target in MLLr Leukemogenesis. diagnostic usage,ongoing research,unassigned 3,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450196&form=6&db=m MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33593829&form=6&db=m Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33603962&form=6&db=m Methionine Adenosyltransferase Inhibitors for the Treatment of Cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33656855&form=6&db=m Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A. causal interaction,unassigned 3,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33756106&form=6&db=m mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. ongoing research,unassigned 2,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33829783&form=6&db=m Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33859984&form=6&db=m SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893330&form=6&db=m Transition state analogue of MTAP extends lifespan of APCMin/+ mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33900758&form=6&db=m Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model. therapeutic application,unassigned 4,0 2.5.1.6 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34349244&form=6&db=m Deregulated 14-3-3? and methionine adenosyltransferase ?1 interplay promotes liver cancer tumorigenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.5.1.6 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8866660&form=6&db=m Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 2.5.1.6 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9515567&form=6&db=m Regulation of methionine adenosyltransferase catalytic activity and messenger RNA in SH-SY5Y human neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.5.1.6 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213491&form=6&db=m S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.5.1.6 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22951388&form=6&db=m Methionine adenosyltransferase I/III deficiency: Neurological manifestations and relevance of S-adenosylmethionine. causal interaction,therapeutic application,unassigned 3,1,0 2.5.1.6 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060674&form=6&db=m Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.5.1.6 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20815019&form=6&db=m Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. causal interaction,ongoing research,unassigned 4,4,0 2.5.1.6 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21837751&form=6&db=m Methionine adenosyltransferase 1A gene deletion disrupts hepatic VLDL assembly in mice. causal interaction,ongoing research,unassigned 3,3,0 2.5.1.6 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33284502&form=6&db=m Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome. ongoing research,unassigned 4,0 2.5.1.6 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060674&form=6&db=m Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 2.5.1.6 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21108044&form=6&db=m Effect of maternal folic acid supplementation on hepatic one-carbon unit associated gene expressions in newborn piglets. ongoing research,unassigned 2,0 2.5.1.6 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28274171&form=6&db=m Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity. unassigned - 2.5.1.6 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29035364&form=6&db=m Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. causal interaction,therapeutic application,unassigned 3,4,0 2.5.1.6 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29807623&form=6&db=m Macrophages in obesity. ongoing research,unassigned 2,0 2.5.1.6 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24691750&form=6&db=m Statistical Shape and Appearance Models in Osteoporosis. ongoing research,unassigned 2,0 2.5.1.6 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12424217&form=6&db=m Role of S-adenosylmethionine in two experimental models of pancreatitis. diagnostic usage,unassigned 3,0 2.5.1.6 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29039163&form=6&db=m [Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 2.5.1.6 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31737040&form=6&db=m Expanded Newborn Screening for Inborn Errors of Metabolism by Tandem Mass Spectrometry in Suzhou, China: Disease Spectrum, Prevalence, Genetic Characteristics in a Chinese Population. causal interaction,therapeutic application,unassigned 2,2,0 2.5.1.6 Porphyria, Erythropoietic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33284502&form=6&db=m Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome. ongoing research,unassigned 4,0 2.5.1.6 Precancerous Conditions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21562899&form=6&db=m A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma. unassigned - 2.5.1.6 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23883427&form=6&db=m The Study of Active Monitoring in Sweden (SAMS): A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.5.1.6 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24102230&form=6&db=m Editorial Comment to: SAMS: A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.5.1.6 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24102231&form=6&db=m Editorial Comment to: SAMS: A randomized study comparing two different follow-up schedules for active surveillance of low-risk prostate cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0 2.5.1.6 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141455&form=6&db=m Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.5.1.6 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32662309&form=6&db=m The value of a first MRI and targeted biopsies after several years of active surveillance for low-risk prostate cancer - results from the SAMS trial. therapeutic application,unassigned 4,0 2.5.1.6 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259182&form=6&db=m Messenger RNA for enzymes of ornithine and polyamine metabolism are selectively underexpressed in kidney of 5/6 nephrectomized rats. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 2.5.1.6 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26575138&form=6&db=m Treatment Options for Statin-Associated Muscle Symptoms. causal interaction,unassigned 1,0 2.5.1.6 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26780003&form=6&db=m Statin intolerance. causal interaction,therapeutic application,unassigned 3,1,0 2.5.1.6 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27897416&form=6&db=m Curcumin: An effective adjunct in patients with statin-associated muscle symptoms? causal interaction,unassigned 1,0 2.5.1.6 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28963307&form=6&db=m Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults: a protocol for a systematic review and meta-analysis of randomised controlled trials. therapeutic application,unassigned 1,0 2.5.1.6 Rhabdomyolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31756491&form=6&db=m A practical algorithm for the management of patients with statin-associated muscle symptoms. unassigned - 2.5.1.6 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19615026&form=6&db=m Giant superficial angiomyxoma of the vulva: a case report and review of the literature. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.5.1.6 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=210799&form=6&db=m Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA. therapeutic application,unassigned 3,0 2.5.1.6 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9021952&form=6&db=m Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide. ongoing research,unassigned 4,0 2.5.1.6 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32886102&form=6&db=m Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea: The SAMS Randomized Clinical Trial. causal interaction,therapeutic application,unassigned 1,2,0 2.5.1.6 Spinal Cord Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450654&form=6&db=m Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review. therapeutic application,unassigned 1,0 2.5.1.6 Spinal Cord Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450654&form=6&db=m Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review. therapeutic application,unassigned 1,0 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6806290&form=6&db=m Requirement of ATP in bacterial chemotaxis. ongoing research,unassigned 1,0 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10705372&form=6&db=m YHP1 encodes a new homeoprotein that binds to the IME1 promoter in Saccharomyces cerevisiae. unassigned - 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11097841&form=6&db=m Positive regulation of transcription of homeoprotein-encoding YHP1 by the two-component regulator Sln1 in Saccharomyces cerevisiae. unassigned - 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626738&form=6&db=m Transcription termination control of the S box system: direct measurement of S-adenosylmethionine by the leader RNA. therapeutic application,unassigned 1,0 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660248&form=6&db=m L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. causal interaction,unassigned 1,0 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443014&form=6&db=m [Differential protein analysis on the root response of rice with high phosphorous uptake efficiency to low phosphorous stress]. ongoing research,unassigned 1,0 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28525753&form=6&db=m The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. unassigned - 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365568&form=6&db=m A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei. unassigned - 2.5.1.6 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33007541&form=6&db=m Pre- sowing seed treatment with salicylic acid and sodium hydrosulfide confers Pb toxicity tolerance in maize (Zea mays L.). unassigned - 2.5.1.6 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22542325&form=6&db=m Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.5.1.6 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20335551&form=6&db=m MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 2.5.1.6 Subacute Combined Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1628209&form=6&db=m Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase. therapeutic application,unassigned 4,0 2.5.1.6 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450654&form=6&db=m Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review. therapeutic application,unassigned 1,0 2.5.1.6 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33237943&form=6&db=m Modeling statin myopathy in a human skeletal muscle microphysiological system. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0 2.5.1.6 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16095837&form=6&db=m Study of fibrinogen adsorption on self-assembled monolayers on Au(111) by atomic force microscopy. unassigned - 2.5.1.6 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31061538&form=6&db=m Methionine is a metabolic dependency of tumor-initiating cells. causal interaction,unassigned 1,0 2.5.1.6 Trypanosomiasis, African http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8457607&form=6&db=m S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei. ongoing research,therapeutic application,unassigned 1,2,0 2.5.1.6 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12809568&form=6&db=m Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis. therapeutic application,unassigned 1,0 2.5.1.6 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15670956&form=6&db=m Comparative protein modeling of methionine S-adenosyltransferase (MAT) enzyme from Mycobacterium tuberculosis: a potential target for antituberculosis drug discovery. ongoing research,therapeutic application,unassigned 3,2,0 2.5.1.6 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33906605&form=6&db=m A systematic review of the quality of conduct and reporting of survival analyses of tuberculosis outcomes in Africa. ongoing research,therapeutic application,unassigned 3,1,0 2.5.1.6 Tyrosinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=564605&form=6&db=m Hypermethioninemia in an infant. causal interaction,unassigned 3,0 2.5.1.6 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31600961&form=6&db=m Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.5.1.6 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33138667&form=6&db=m Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase II alpha (MAT2A) expression by restraining microRNA-101-5p. causal interaction,unassigned 2,0 2.5.1.6 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28994391&form=6&db=m A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection. unassigned - 2.5.1.6 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32497121&form=6&db=m dBMHCC: A comprehensive hepatocellular carcinoma (HCC) biomarker database provides a reliable prediction system for novel HCC phosphorylated biomarkers. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 2.5.1.6 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30935447&form=6&db=m Vitamin D Supplementation to Treat Statin-Associated Muscle Symptoms: A Review. causal interaction,diagnostic usage,unassigned 4,1,0 2.5.1.6 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31019583&form=6&db=m Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain. ongoing research,unassigned 1,0